216:
to deduce enzyme mechanisms, especially those involved in phospho and acyl transfers. He pioneered the kinetic and mechanistic study of enzymes with more than one substrate, and he was probably the first to make a systematic classification of mechanisms and the corresponding kinetic equations.
195:
he returned to
University of Wisconsin–Madison, where he became assistant professor in 1959. In 1962 he was promoted to associate professor and then professor in 1966. He became J. Johnson Professor of Biochemistry in 1978, and Steenbock Professor of Chemical Science in 1982.
806:
28:
799:
792:
1050:
815:
275:
175:
in 1950 and his M.S. and Ph.D. from the
University of Wisconsin–Madison in 1953 and 1955, respectively. He was an avid stamp collector and was awarded the Lifetime Achievement Award in
261:
1070:
1065:
227:
In the latter part of his career
Cleland contributed greatly to studies of the use of kinetic isotope effects as a tool for elucidating mechanisms of enzyme catalysis.
156:
732:
1075:
716:
754:
1060:
144:
779:
336:
1055:
224:
programs that implement
Wilkinson's analysis, which he distributed to anyone who requested them, were very influential.
976:
994:
784:
372:
234:
for the reduction of disulfide bonds in proteins, and the compound is accordingly often called
Cleland's reagent.
268:
217:
Building on this work he made kinetic studies of various enzymes, including isotope exchange of creatine kinase.
1012:
289:
180:
124:
78:
514:"Isotope Exchange Studies of the Reaction Catalyzed by Adenosine Triphosphate: Creatine Phosphotransferase"
485:
Cleland, W.W (1963). "The kinetics of enzyme-catalyzed reactions with two or more substrates or products".
458:
Cleland, W.W (1963). "The kinetics of enzyme-catalyzed reactions with two or more substrates or products".
431:
Cleland, W.W (1963). "The kinetics of enzyme-catalyzed reactions with two or more substrates or products".
988:
958:
192:
1000:
856:
780:
Perry Allen Frey, "W. Wallace
Cleland", Biographical Memoirs of the National Academy of Sciences (2014)
838:
1045:
1040:
922:
904:
554:
964:
928:
844:
168:
48:
916:
850:
578:
874:
868:
712:
689:
627:
570:
312:
970:
952:
892:
862:
681:
654:
617:
609:
562:
525:
494:
467:
440:
411:
199:
Kresge, Simoni and Hill have presented a general appreciation of
Cleland's life and career.
1018:
946:
898:
213:
172:
152:
71:
558:
886:
826:
622:
597:
231:
672:
Cleland, W.W. (April 1964). "Dithiothreitol, A New
Protective Reagent for SH Groups".
530:
513:
416:
399:
220:
Cleland was a pioneer in the use of computers to analyze enzyme kinetic data, and his
27:
1034:
940:
934:
910:
832:
498:
471:
444:
1006:
982:
582:
487:
Biochimica et
Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects
460:
Biochimica et
Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects
433:
Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects
400:"Determining enzyme mechanisms by kinetic analysis: The work of W. Wallace Cleland"
114:
545:
Cleland, W. W. (1963). "Computer Programmes for Processing Enzyme Kinetic Data".
360:
645:
Cleland, W. W. (2007). "Use of isotope effects to determine enzyme mechanisms".
285:
176:
693:
631:
574:
685:
294:
2014 - 36th Steenbock Symposium - In honor of the life of W. W. Cleland
221:
658:
613:
566:
148:
267:
1993 - Alfred Bader Award in Bioinorganic or Bioorganic Chemistry (
278:(Biological Chemistry Division of the American Chemical Society)
816:
Repligen Corporation Award in Chemistry of Biological Processes
788:
276:
Repligen Corporation Award in Chemistry of Biological Processes
155:, especially multiple-substrate enzymes. He was elected to the
183:
in 2008. Cleland died on March 6, 2013, after falling on ice.
1051:
Members of the United States National Academy of Sciences
147:
biochemistry professor. His research was concerned with
262:
American Society for Biochemistry and Molecular Biology
139:(January 6, 1930 – March 6, 2013, often cited as
647:
Journal of Labelled Compounds and Radiopharmaceuticals
379:. Department of Biochemistry, UW-Madison. 6 March 2013
143:, and known almost universally as "Mo Cleland", was a
398:Kresge; Simoni, Robert D.; Hill, Robert L. (2006).
120:
110:
95:
87:
67:
55:
34:
18:
254:1985 - Elected to the National Academy of Sciences
191:After carrying out postdoctoral research at the
755:"36th Symposium: Enzyme Structure and Function"
373:"Biochemistry Mourns the Loss of "Mo" Cleland"
281:1999 - Stein and Moore Award (Protein Society)
800:
707:Cook, Paul; Cleland, William Wallace (2007).
8:
598:"Statistical estimations in enzyme kinetics"
807:
793:
785:
26:
15:
621:
529:
415:
332:
330:
212:Cleland's research focused on the use of
1071:University of Wisconsin–Madison faculty
304:
1066:University of Wisconsin–Madison alumni
512:Morrison, J.F.; Cleland, W.W. (1966).
356:
354:
352:
350:
348:
346:
344:
284:2008 - Lifetime Achievement Award in
257:1986 - Fulbright Senior Scholar Award
7:
361:J. Biol. Chem. biographical article
14:
757:. University of Wisconsin–Madison
145:University of Wisconsin-Madison
315:. National Academy of Sciences
1:
735:. Madison.com. March 10, 2013
709:Enzyme kinetics and mechanism
531:10.1016/S0021-9258(18)96891-2
417:10.1016/S0021-9258(19)35036-7
243:Enzyme Kinetics and Mechanism
91:Enzyme kinetics and mechanism
1076:Accidental deaths from falls
499:10.1016/0926-6569(63)90226-8
472:10.1016/0926-6569(63)90211-6
445:10.1016/0926-6569(63)90227-X
171:. He received his A.B. from
167:Cleland was born in 1930 in
157:National Academy of Sciences
711:. London: Garland Science.
1092:
733:"Cleland, W. Wallace "Mo""
82:(M.S., 1953) (Ph.D., 1955)
822:
269:American Chemical Society
130:
103:
25:
245:(with P. F. Cook, 2007)
230:He was the first to use
203:Scientific contributions
1013:Wilfred A. van der Donk
290:Smithsonian Institution
181:Smithsonian Institution
151:reaction mechanism and
137:William Wallace Cleland
125:University of Wisconsin
79:University of Wisconsin
20:William Wallace Cleland
1061:Oberlin College alumni
596:Wilkinson, GN (1961).
249:Awards and recognition
989:David W. Christianson
193:University of Chicago
1056:American biochemists
905:Christopher T. Walsh
653:(11–12): 1006–1015.
260:1990 - Merck Award (
863:Frank H. Westheimer
845:Stephen J. Benkovic
686:10.1021/bi00892a002
602:Biochemical Journal
559:1963Natur.198..463C
169:Baltimore, Maryland
49:Baltimore, Maryland
959:Hung-Wen (Ben) Liu
917:Rowena G. Matthews
899:David S. Eisenberg
881:W. Wallace Cleland
851:Harold A. Scheraga
337:Academic home page
163:Life and education
1028:
1027:
1001:John S. Blanchard
977:Richard Armstrong
887:William P. Jencks
875:Judith P. Klinman
869:Jeremy R. Knowles
857:William W. Parson
718:978-0-8153-4140-6
659:10.1002/jlcr.1390
614:10.1042/bj0800324
553:(4879): 463–465.
134:
133:
105:Scientific career
83:
76:
1083:
971:Ronald T. Raines
953:Michael Marletta
893:James A. Spudich
839:Robert H. Abeles
833:Thomas C. Bruice
809:
802:
795:
786:
767:
766:
764:
762:
751:
745:
744:
742:
740:
729:
723:
722:
704:
698:
697:
669:
663:
662:
642:
636:
635:
625:
593:
587:
586:
567:10.1038/198463a0
542:
536:
535:
533:
509:
503:
502:
482:
476:
475:
455:
449:
448:
428:
422:
421:
419:
395:
389:
388:
386:
384:
369:
363:
358:
339:
334:
325:
324:
322:
320:
309:
81:
74:
62:
44:
42:
30:
16:
1091:
1090:
1086:
1085:
1084:
1082:
1081:
1080:
1031:
1030:
1029:
1024:
1019:Michael H. Gelb
947:Vern L. Schramm
923:C. Dale Poulter
818:
813:
776:
771:
770:
760:
758:
753:
752:
748:
738:
736:
731:
730:
726:
719:
706:
705:
701:
671:
670:
666:
644:
643:
639:
595:
594:
590:
544:
543:
539:
511:
510:
506:
484:
483:
479:
457:
456:
452:
430:
429:
425:
397:
396:
392:
382:
380:
371:
370:
366:
359:
342:
335:
328:
318:
316:
311:
310:
306:
301:
251:
240:
214:enzyme kinetics
210:
205:
189:
173:Oberlin College
165:
153:enzyme kinetics
77:
72:Oberlin College
68:Alma mater
60:
51:
46:
45:January 6, 1930
40:
38:
21:
12:
11:
5:
1089:
1087:
1079:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1033:
1032:
1026:
1025:
1023:
1022:
1016:
1010:
1004:
998:
992:
986:
980:
974:
968:
962:
956:
950:
944:
938:
932:
926:
920:
914:
908:
902:
896:
890:
884:
878:
872:
866:
860:
854:
848:
842:
836:
830:
827:Gregorio Weber
823:
820:
819:
814:
812:
811:
804:
797:
789:
783:
782:
775:
774:External links
772:
769:
768:
746:
724:
717:
699:
664:
637:
608:(2): 324–332.
588:
537:
524:(3): 673–683.
504:
477:
450:
423:
390:
364:
340:
326:
303:
302:
300:
297:
296:
295:
292:
282:
279:
272:
265:
258:
255:
250:
247:
239:
236:
232:dithiothreitol
209:
206:
204:
201:
188:
185:
164:
161:
132:
131:
128:
127:
122:
118:
117:
112:
108:
107:
101:
100:
99:Repligen Award
97:
93:
92:
89:
88:Known for
85:
84:
69:
65:
64:
63:(aged 83)
57:
53:
52:
47:
36:
32:
31:
23:
22:
19:
13:
10:
9:
6:
4:
3:
2:
1088:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1038:
1036:
1020:
1017:
1014:
1011:
1008:
1005:
1002:
999:
996:
995:John Lipscomb
993:
990:
987:
984:
981:
978:
975:
972:
969:
966:
965:Frank Raushel
963:
960:
957:
954:
951:
948:
945:
942:
941:David E. Cane
939:
936:
935:JoAnne Stubbe
933:
930:
929:John A. Gerlt
927:
924:
921:
918:
915:
912:
911:Perry A. Frey
909:
906:
903:
900:
897:
894:
891:
888:
885:
882:
879:
876:
873:
870:
867:
864:
861:
858:
855:
852:
849:
846:
843:
840:
837:
834:
831:
828:
825:
824:
821:
817:
810:
805:
803:
798:
796:
791:
790:
787:
781:
778:
777:
773:
756:
750:
747:
734:
728:
725:
720:
714:
710:
703:
700:
695:
691:
687:
683:
679:
675:
668:
665:
660:
656:
652:
648:
641:
638:
633:
629:
624:
619:
615:
611:
607:
603:
599:
592:
589:
584:
580:
576:
572:
568:
564:
560:
556:
552:
548:
541:
538:
532:
527:
523:
519:
518:J. Biol. Chem
515:
508:
505:
500:
496:
492:
488:
481:
478:
473:
469:
465:
461:
454:
451:
446:
442:
438:
434:
427:
424:
418:
413:
409:
405:
404:J. Biol. Chem
401:
394:
391:
378:
374:
368:
365:
362:
357:
355:
353:
351:
349:
347:
345:
341:
338:
333:
331:
327:
314:
313:"In Memoriam"
308:
305:
298:
293:
291:
287:
283:
280:
277:
273:
270:
266:
263:
259:
256:
253:
252:
248:
246:
244:
237:
235:
233:
228:
225:
223:
218:
215:
207:
202:
200:
197:
194:
186:
184:
182:
178:
174:
170:
162:
160:
158:
154:
150:
146:
142:
141:W. W. Cleland
138:
129:
126:
123:
119:
116:
113:
109:
106:
102:
98:
94:
90:
86:
80:
73:
70:
66:
59:March 6, 2013
58:
54:
50:
37:
33:
29:
24:
17:
1007:Tadhg Begley
983:Carol Fierke
880:
759:. Retrieved
749:
737:. Retrieved
727:
708:
702:
680:(4): 480–2.
677:
674:Biochemistry
673:
667:
650:
646:
640:
605:
601:
591:
550:
546:
540:
521:
517:
507:
490:
486:
480:
463:
459:
453:
436:
432:
426:
407:
403:
393:
381:. Retrieved
376:
367:
317:. Retrieved
307:
242:
241:
229:
226:
219:
211:
198:
190:
166:
140:
136:
135:
121:Institutions
115:Biochemistry
104:
75:(A.B., 1950)
61:(2013-03-06)
1046:2013 deaths
1041:1930 births
493:: 173–187.
466:: 104–137.
439:: 188–196.
410:(46): e37.
1035:Categories
299:References
41:1930-01-06
761:29 August
377:News 2013
286:Philately
177:Philately
159:in 1985.
739:12 March
694:14192894
632:13785321
575:14021666
274:1995 -
623:1244002
583:4261285
555:Bibcode
383:9 March
319:8 March
222:Fortran
179:by the
1021:(2018)
1015:(2017)
1009:(2016)
1003:(2015)
997:(2014)
991:(2013)
985:(2012)
979:(2011)
973:(2010)
967:(2009)
961:(2008)
955:(2007)
949:(2006)
943:(2005)
937:(2004)
931:(2003)
925:(2002)
919:(2001)
913:(2000)
907:(1999)
901:(1998)
895:(1997)
889:(1996)
883:(1995)
877:(1994)
871:(1993)
865:(1992)
859:(1991)
853:(1990)
847:(1989)
841:(1988)
835:(1987)
829:(1986)
715:
692:
630:
620:
581:
573:
547:Nature
208:Papers
187:Career
149:enzyme
111:Fields
96:Awards
579:S2CID
763:2023
741:2013
713:ISBN
690:PMID
628:PMID
571:PMID
385:2013
321:2013
238:Book
56:Died
35:Born
682:doi
655:doi
618:PMC
610:doi
563:doi
551:198
526:doi
522:241
495:doi
468:doi
441:doi
412:doi
408:281
1037::
688:.
676:.
651:50
649:.
626:.
616:.
606:80
604:.
600:.
577:.
569:.
561:.
549:.
520:.
516:.
491:67
489:.
464:67
462:.
437:67
435:.
406:.
402:.
375:.
343:^
329:^
288:,
808:e
801:t
794:v
765:.
743:.
721:.
696:.
684::
678:3
661:.
657::
634:.
612::
585:.
565::
557::
534:.
528::
501:.
497::
474:.
470::
447:.
443::
420:.
414::
387:.
323:.
271:)
264:)
43:)
39:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
