393:
between science and marketing. WIL Research emphasized direct scientist-to-scientist interaction as much as possible across the entire scope of each project, which gained the company numerous accolades from its clients. Examples of the types of projects undertaken by WIL Research included studies of
586:
Under the ownership of
American Capital, David Spaight was named Chairman and CEO of the global holding company in 2010, which undertook a re-branding and global integration effort. During the ACAS-led period, growth of the company occurred primarily through additional acquisitions, including those
372:
was well-known as an energetic, outgoing leader with a vision for the company that revolved around the success of his staff and ongoing recruitment efforts. Critical to the success of WIL Research was a continuous investment in staff training, as new biologists typically underwent a 9-12 month
530:
led WIL Research through an initial period of private capital-financed expansion. In 2004, Holson and four other senior executives (Mark D. Nemec, Dr. Christopher P. Chengelis, Dr. Daniel W. Sved, and James M. Rudar) initiated a management buyout (in partnership with
348:
services to a globally diverse client base. Underpinning the continuous expansion of service capabilities was a steady expansion of the company's facilities from approximately 30,000 square feet to more than 300,000 square feet of dedicated
518:'s Science Advisory Board (1990-2008) and Board of Trustees (1993-1998), and gave the initial lecture, entitled "Risk and Regulation," of a year-long lecture series in support of the university's Environmental Studies program in 1995.
319:
tenure, WIL Research continuously expanded its scientific capabilities, facilities, and staffing levels. During this period, the company grew from a limited mammalian toxicology research laboratory into a robust interdisciplinary
253:, with Briggs serving as the company's first president. The company was initially a limited mammalian toxicological testing laboratory that conducted short-term studies for several clients in the Cincinnati area. In 1978,
462:
laboratories. WTDMS™ was licensed to several other toxicology testing laboratories, and was used continuously by WIL Research
Laboratories for nearly forty years prior to its gradual replacement by the Provantis system.
607:
site) was opened in 2015 to augment the
European operations. These activities combined to increase the total number of employees in the global entity to more than 1300, with total 2015 revenues of $ 215 million.
433:
Although highly respected in many disciplines, WIL Research was considered by many to be the leading laboratory in the world for developmental and reproductive toxicology (DART). This leadership was driven by
389:, which viewed each study director as an individual business unit with scientific, project management, and marketing responsibilities. This approach was in contrast to the typical division within
510:, with many of its senior scientists serving as adjunct professors in their areas of expertise, especially in the undergraduate toxicology program, which the company helped begin in 1984.
499:, an award recognizing "the foresight, diligence and unselfishness of individuals or organizations who contribute to new growth, strengthen the roots or improve the overall community of
1376:
442:
and subsequently by Mr. Mark D. Nemec and Dr. Donald G. Stump, became known not only for high-quality regulatory guideline studies, but also for innovative, specialized DART research.
373:
training period and all employees regularly completed continuing education not only in their specific areas of expertise but also in the subjects of animal care and welfare,
643:
284:
was named
President and Director of WIL Research Laboratories in 1988. Under his leadership over the next 20 years, WIL Research grew from 31 employees into a dynamic
886:
377:, and research integrity. Many of the internal training programs developed at WIL Research were highly regarded and requested by clients and industry partners.
1369:
296:, internationally recognized scientific prowess (particularly in DART), internally developed innovations (including the industry's first protocol-driven
221:. WIL Research was well-known internationally in many disciplines, and considered by many industry experts to be the premier laboratory in the world for
1305:
1161:
964:
1669:
1362:
1186:
1136:
691:
454:
testing services, the WIL Toxicology Data
Management System (WTDMS™) was developed. This protocol-driven software system was the first in the
989:
1039:
1063:
1211:
1434:
1399:
1112:
491:
added that WIL Research at that time served approximately 550 clients (domestic and international), most of whom regularly visited
1280:
536:
254:
1674:
555:), and the subsequent $ 500 million sale of WRH, Inc. to American Capital, Ltd. (NASDAQ:ACAS) in 2007. After the sale to ACAS,
222:
1385:
623:, acquired the global holdings of WIL Research for $ 585 million in cash. The platform WIL Research Laboratories facility in
483:
tenure, the company invested approximately $ 62 million in facilities renovation and expansion. In a talk given to the local
455:
390:
321:
285:
174:
539:
which led to the formation of a holding company (WRH, Inc.). The expansion continued with the merger of
Biotechnics, LLC (
540:
1088:
861:
825:
751:
1409:
1404:
616:
345:
194:
144:
1255:
911:"Ashland University Offers Unique Toxicology Degree Program | College of Arts & Sciences | Ashland University"
1580:
612:
292:
site. This success was attributed to the company's entrepreneurial scientific management, study director-centric
1648:
1459:
580:
560:
374:
572:
438:, an internationally recognized authority in the field. The DART division at WIL Research, led initially by
341:
198:
186:
134:
364:
vision, though, was a drive to continually deepen the company's talent pool, as the number of employees in
552:
399:
563:
of the global entity while continuing to serve as
President and Director of WIL Research Laboratories in
1330:
250:
328:, inhalation toxicology, developmental neurotoxicology, large animal toxicology, juvenile toxicology,
246:
484:
337:
242:
129:
1633:
1499:
1479:
1419:
990:"Behrman Capital and Texas Pacific Group Announce Acquisition of NOTOX Beheer BV - Behrman Capital"
604:
548:
532:
329:
190:
139:
1595:
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1504:
1444:
515:
507:
459:
422:
149:
1064:"Behrman Capital Sells WIL Research Laboratories in $ 500 Million Transaction - Behrman Capital"
495:
to monitor their studies. In 2006, WIL Research received the Golden Oak award from the mayor of
1229:
206:
591:, led by Dr. Michael Schlosser) and Ricerca Bioscience's pharmaceutical services facility in
551:, let by Jan van der Hoeven, Dr. Wilbert Frieling, and Dr. Ilona Enninga) and QS Pharma LLC (
1429:
648:
588:
568:
556:
527:
511:
488:
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435:
369:
361:
316:
281:
102:
666:
261:, subsequently acquired the 75-acre Hess & Clark research facility on the outskirts of
1241:
620:
419:
325:
300:
182:
124:
28:
692:"WIL Research Laboratories, LLC Acquires Midwest BioResearch, LLC. - Free Online Library"
273:
enabled WIL to conduct a larger number of studies as it began to expand its client base.
887:"Chandler Systems, WIL honored/ Ashland businesses receive Golden Oak awards from mayor"
395:
386:
293:
218:
38:
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area for a steady supply of qualified personnel, it also contributed extensively to
257:
acquired WIL Research
Laboratories. By 1980, WIL Research outgrew its facilities in
210:
46:
1354:
1560:
1509:
600:
1484:
451:
350:
333:
297:
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economic growth, becoming one of the largest employers in the county. During
173:(acquired in 2016 and renamed Charles River Laboratories Ashland, LLC) was a
1585:
1530:
1525:
1474:
415:
810:"You're in Good Company in Ohio: Featuring WIL Research Laboratories Inc".
595:(led by Stéphane Bulle). In addition, a new safety assessment facility in
1570:
1545:
1439:
1424:
1212:"WIL Research Acquires Ricerca's Pharma Service Business in Lyon, France"
829:
411:
403:
354:
269:, and by 1982 had moved its operations to the new location. The move to
1638:
1628:
1555:
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1469:
1464:
1454:
910:
596:
1306:"Charles River Laboratories Completes the Acquisition of WIL Research"
667:"Charles River Laboratories Completes the Acquisition of WIL Research"
1643:
1414:
965:"Great Lakes Chemical sells WIL Research Labs; allies with ChlorKing"
627:
was subsequently renamed to
Charles River Laboratories Ashland, LLC.
407:
862:"WIL Research Partners With Instem For Global Harmonization Project"
385:
A key driver of WIL's steady growth was its study director-centric
1612:
1600:
1535:
1449:
1162:"WIL Research Laboratories, LLC Acquires Midwest BioResearch, LLC"
1040:"Investment firm sells interest in WIL Research for $ 500 million"
579:
flagship facility, and Dr. Chengelis was named Vice
President and
177:(CRO), privately held for 40 years, that provided product safety
1137:"WIL Research Appoints David Spaight as Chief Executive Officer"
592:
266:
238:
1358:
429:
Global leadership in developmental and reproductive toxicology
786:"25 Who Are Making a Difference. Featuring: Joseph Holson".
543:, led by Dr. George Parker) with WIL Research operations in
1256:"WIL Research Opens New Facility in the Netherlands - NFIA"
1281:"Wilmington's Charles River Labs To Acquire WIL Research"
617:
Charles River Laboratories International, Inc. (NYSE:CRL)
526:
After nearly two decades of sustained organic growth,
934:"Ashland mayor fêtes two long-time city businesses".
644:"Charles River Laboratories to Acquire WIL Research"
324:
offering developmental and reproductive toxicology,
1621:
1518:
1392:
1331:"Charles River Laboratories Ashland, LLC | BioOhio"
1113:"WIL promotes area man to chief scientific officer"
158:
112:
96:
86:
78:
70:
52:
34:
24:
571:retirement, Mr. Nemec was appointed President and
458:industry and became the prototype for other major
107:(President during sustained organic growth phase)
233:WIL Research Laboratories was founded in 1976 in
217:industries, as well as manufacturing support for
303:software system), and strong involvement in the
733:"WIL Research utilizes area people resources".
1370:
8:
567:until his retirement in November 2008. Upon
19:
752:"WIL Research Laboratories Company Profile"
471:While WIL Research depended on the broader
288:employing more than 600 individuals at the
1377:
1363:
1355:
1089:"Nemec promoted to lead WIL Research Labs"
18:
16:Contract research organization in Ohio, US
1015:"WIL Research Acquires QS Pharma | Mergr"
223:developmental and reproductive toxicology
949:"WIL president assesses chemical risk".
635:
547:, the acquisitions of Notox Beheer BV (
82:Charles River Laboratories Ashland, LLC
1237:
1227:
841:
839:
506:WIL Research also actively supported
381:Study director-centric business model
311:Entrepreneurial scientific management
7:
1210:Editors, Pharmaceutical Technology.
1187:"WIL Research Acquires Ricerca Lyon"
805:
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686:
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1435:George Institute for Global Health
826:"Archived copy of wilresearch.com"
715:"WIL announces ownership change".
450:In 1978, as a result of expanding
14:
537:Great Lakes Chemical Corporation
418:, and replacement chemicals for
255:Great Lakes Chemical Corporation
1670:Contract research organizations
846:"WIL Research Labs to expand".
368:grew from 31 to more than 600.
1386:Contract research organization
936:News-Journal (Mansfield, Ohio)
357:, and support services space.
286:contract research organization
175:contract research organization
171:WIL Research Laboratories, LLC
1:
669:(Press release). 4 April 2016
587:of Midwest BioResearch, LLC (
559:served as Vice President and
549:'s-Hertogenbosch, Netherlands
394:drugs for the treatment of
58:; 48 years ago
1691:
1519:Clinical and Healthcare IT
1410:Charles River Laboratories
1405:Cancer Trials Support Unit
145:Pharmaceutical formulation
1581:Tata Consultancy Services
1495:WIL Research Laboratories
375:Good Laboratory Practices
20:WIL Research Laboratories
1649:Thermo Fisher Scientific
1460:Labcorp Drug Development
581:Chief Scientific Officer
561:Chief Scientific Officer
522:Mergers and acquisitions
277:Sustained organic growth
603:(close to the existing
573:Chief Operating Officer
425:in fire extinguishers.
342:bioanalytical chemistry
135:Bioanalytical chemistry
1675:Life sciences industry
696:www.thefreelibrary.com
535:Behrman Capital) from
1644:Syngene International
951:Ashland Times-Gazette
848:Ashland Times-Gazette
788:Ashland Times-Gazette
735:Ashland Times-Gazette
717:Ashland Times-Gazette
1310:www.businesswire.com
1166:www.businesswire.com
1141:www.businesswire.com
938:. 15 September 2006.
737:. 15 September 1982.
282:Dr. Joseph F. Holson
130:Analytical chemistry
74:G. Bruce Briggs, DVM
1500:WNS Global Services
1480:PRA Health Sciences
1420:Craven Laboratories
953:. 15 November 1995.
814:. 18 December 1995.
790:. 27 February 2007.
533:private equity firm
446:Internal innovation
423:chlorofluorocarbons
400:Alzheimers' disease
330:safety pharmacology
160:Number of employees
140:Safety pharmacology
21:
1596:UnitedHealth Group
1576:Oracle Corporation
1566:Medidata Solutions
1505:Wolfe Laboratories
1240:has generic name (
969:www.waterworld.com
516:Ashland University
508:Ashland University
460:toxicology testing
150:Regulatory affairs
1657:
1656:
1393:Clinical Research
1216:www.pharmtech.com
719:. 6 October 2004.
512:Dr. Joseph Holson
467:Ashland Community
436:Dr. Joseph Holson
251:Robert W. Brigham
168:
167:
164:1,300 (2016)
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1430:ePharmaSolutions
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885:Edwards, Megan.
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866:www.biospace.com
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828:. Archived from
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649:The Boston Globe
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541:Hillsborough, NC
360:At the heart of
247:Ralph S. Hodgdon
197:services to the
108:
103:Joseph F. Holson
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1191:Contract Pharma
1185:
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1168:(Press release)
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1143:(Press release)
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1068:Behrman Capital
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994:Behrman Capital
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915:www.ashland.edu
909:
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850:. 30 July 2003.
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621:James C. Foster
611:In early 2016,
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514:also served on
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448:
431:
420:ozone-depleting
383:
326:neurotoxicology
313:
301:data management
279:
243:G. Bruce Briggs
231:
219:clinical trials
191:pharmacological
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125:Drug metabolism
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1351:External links
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1312:. 4 April 2016
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971:. October 2004
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832:on 2008-06-08.
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613:Wilmington, MA
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387:business model
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