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Fiers W, Contreras R, Duerinck F, Haegeman G, Iserentant D, Merregaert J, Min Jou W, Molemans F, Raeymaekers A, Van den Berghe A, Volckaert G, Ysebaert M., Complete nucleotide-sequence of bacteriophage MS2-RNA - primary and secondary structure of replicase gene, Nature, 260, 500–507,
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At the end of 1962, Fiers returned to
Belgium and set up the Laboratory of Molecular Biology at the University of Ghent. His research involved Bacteriophage MS2; he was the first to establish the complete nucleotide sequence of a gene (1972) and of a viral genome
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De
Filette M, Ramne A, Birkett A, Lycke N, Löwenadler B, Min Jou W, Saelens X, Fiers W, The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection, Vaccine. 2006 January
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Fiers W, Contreras R, Haegemann G, Rogiers R, Van de Voorde A, Van
Heuverswyn H, Van Herreweghe J, Volckaert G, Ysebaert M., Complete nucleotide-sequence of SV40 DNA, Nature, 273, 113–120, 1978
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De
Filette M, Min Jou W, Birkett A, Lyons K, Schultz B, Tonkyro A, Resch S, Fiers W, Universal influenza A vaccine: optimization of M2-based constructs, Virology. 2005 June 20;337(1):149–61
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Neirynck S, Deroo T, Saelens X, Vanlandschoot P, Jou WM, Fiers W, A universal influenza A vaccine based on the extracellular domain of the M2 protein, Nat Med. 1999 Oct;5(10):1157–63
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on the surface of the influenza A virus. The ectodomain of the M2 protein remains unchanged in all human influenza viruses known, including the strains that caused the
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In 1997 Fiers retired and became
Professor Emeritus, the following year he retired from his position as director of the Laboratory of Molecular Biology. Together with
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Fiers, W., and R. L. Sinsheimer, The structure of the DNA of bacteriophage PhiX 174. III. Ultracentrifuge evidence for a ring structure, J. Mol. Biol. 5:424–434, 1962
127:. The development of totally new procedures and knowledge led to the ability to clone almost any gene and to replicate these efficiently into bacteria or in other
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Fiers W, Neirynck S, Deroo T, Saelens X, Jou WM, Soluble recombinant influenza vaccines, Philos Trans R Soc Lond B Biol Sci. 2001 December 29;356(1416):1961–3
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Min Jou W, Haegeman G, Ysebaert M, Fiers W., Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein, Nature. 1972 May 12;237(5350):82–8
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Remaut E et al., Plasmid vectors for high-efficiency expression controlled by the PL promoter of coliphage-lambda, Gene, 15, 81–93, 1981
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in the last century, which makes it eligible for a universal influenza A vaccine.
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He obtained a degree of
Engineer for Chemistry and Agricultural Industries at the
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UGent - Academic bibliography, list of publications of Walter Fiers
245:"Walter Fiers, pionier van de Vlaamse biotechnologie, is overleden"
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92:. He demonstrated the physical, covalently closed circularity of
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and their team, he continued his research, to find a universal
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human influenza A vaccine, Virus Res. 2004 Jul;103(1–2):173–6
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Fiers W, De
Filette M, Birkett A, Neirynck S, Min Jou W, A
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The Dr. A. De Leeuw-Damry-Bourlart
Excellence prize
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45:in 1954, and started his research career as an
72:). In 1960, he obtained a fellowship from the
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182:Carlos J. Finlay Prize for Microbiology
16:Belgian molecular biologist (1931–2019)
107:, to work in the laboratory of future
53:in Ghent. In 1956–57, he worked with
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189:Artois-Baillet Latour Health Prize
82:California Institute of Technology
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99:DNA. In 1962, Fiers moved to
395:Belgian molecular biologists
84:Walter Fiers was exposed to
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243:NWS, VRT (30 July 2019).
175:Beijerinck Virology Prize
76:and joined the group of
405:Ghent University alumni
51:Laurent Vandendriessche
142:vaccine, based on the
74:Rockefeller Foundation
80:as a postdoc. At the
49:in the laboratory of
38:molecular biologist.
22:(31 January 1931 in
170:for Exact Sciences.
43:University of Ghent
400:Flemish scientists
30:– 28 July 2019 in
390:People from Ypres
196:Robert Koch Prize
121:bacteriophage MS2
86:Molecular Biology
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252:. Retrieved
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219:Jozef Schell
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129:heterologous
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55:Heinz Holter
47:enzymologist
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32:Destelbergen
20:Walter Fiers
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385:2019 deaths
380:1931 births
58: [
374:Categories
230:References
144:M2 protein
66:Copenhagen
334:universal
254:23 August
249:vrtnws.be
148:pandemics
140:influenza
105:Wisconsin
202:See also
97:PhiX-174
34:) was a
131:hosts.
101:Madison
70:Denmark
36:Belgian
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154:Awards
210:(VIB)
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24:Ypres
287:1976
256:2020
125:SV40
90:DNA
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