Knowledge (XXG)

Wang Yinglai

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that constitute proteins, and then used them to produce chains of insulin. His team successfully synthesized insulin in 1965, the first in the world to do so. It was a major breakthrough to produce a biologically active compound from inorganic chemicals.
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merchant, had died four years before. Despite the adverse circumstances, he pursued an education throughout the 1920s and 1930s, when China was mired in wars and turmoil. He graduated from the Department of Chemistry of the
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Hsia C.C., Qi D.F., Wang Y.L., "Studies on Aldolase I, The Protective Action of Substrates on the Action of Trypsin on Aldolase, Acta Biochim et Biophys Sin, 1966,6:70, in Chinese; Kexue Tong Bao 1966, 17:216, in
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Wang J.Y., Wang Y.L., "Studies on Succinic Dehydrogenase IV, The Effect of Some Chelation Agents on the Reconstitution of Succinic Axidase System, Acta Biochim et Biophys Sin, 1964, 4:222;Scientia Sinica, 1964,
506:(1966–1976) intervened and the Chinese Communist government considered the Nobel Prize a symbol of Western decadence. Instead, Wang was held a virtual prisoner in a building at his institute and forced to study 558:, the founder of the Miami Winter Symposium for Biotechnology, created the Special Achievement Award of the symposium and presented the first award to Wang. In 1996, he was nominated by many scientists for the 1435: 1013:
Qi D.F., Wang Y.L., "Studies on Succinic Dehydrogenase V, The Linking between the Flavin Prosthetic Group and the Apoenzyme, Acta Biochim et Biophys Sin, 1964,4: 598; Scientia Sinica, 1965; 14:1193–1204.
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for Achievement in Science and Technology. When he won the award with its prize money of one million yuan, he used it to fund a scholarship for graduate students at the Chinese Academy of Sciences.
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Lin S.X., Shi J.P., Cheng X.D., Wang Y.L., Arginyl tRNA Synthetase from Escherichia Coli, Purification by Affinity Chromatography, Properties and Steady Stat e Kinetics, Biochemistry 1988, 27:6343.
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Wang J.Y., Tsou C.L., Wang Y.L., Studies on Succinic Dehydrogenase Isolation, Purification and Properties, Brussels, 3rd Int. Congress of Biochemistry, 1955 Scientia Sinica, 1956, 5:96–90.
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After the founding of the People's Republic of China in 1949, Wang became deputy director of the newly established Shanghai Institute of Physiology and Biochemistry, under director
642:"Vitamin Methods 3, An Improved Procedure for Estimating Vitamin B1 in Foodstuffs and Biological Materials by the Throchrome Test including Comparisons with Biological Assays" 2444: 1451: 2404: 482:
Wang's most significant contribution was the total chemical synthesis of insulin. He started the project in 1958 with a team of scientists, who first synthesized the 20
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and served as its director until his retirement in 1984. In these capacities, he recruited many prominent Chinese scientists from abroad, including future academicians
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to persuade him to stay at Cambridge. Determined to help develop scientific research in China, he accepted a research professorship at the medical school of the
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Yudkin J., Wang Y.L., "Assessment of the Level of Nutrition, Urinary Excretion of Aneurin at Varying Levels of Intake, Biochem. J., 1940; 34:343–352.
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Wang, Y.L. (1966). "Studies on Succinic Dehydrogenase, Purification, Properties and Linking between the Apoenzyme and the Prosthetic Group".
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Wang established several training programs for young biochemists, many of whom later became accomplished scientists, including academicians
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Chen, S.M.; Hu, H.C.; Wang, Y.L. (1950). "On the Nature of the "Nicotinic Acid" Formed by Rat Liver Slices in the Presence of Tryptophan".
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Lin S.X., Wang Q., Wang Y.L., Interactions between Escherichia Coliarginyl tRNA Sythetase and Its Substrates, Biochemistry, 1988, 27:6348.
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Wang; Holliday, E.R.; et al. (1946). "Assay of Crystalline Preparations of Aneurin by Means of the Ultraviolet Absorption Spectrum".
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After the end of the Cultural Revolution, Wang and his team resumed their work and achieved the synthesis from inorganic chemicals of a
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Wang, J.L.; Tsou, C.L.; Wang, Y.L. (1958). "Studies on Succinic Dehydrogenase II, Further Observations on Properties of the Enzyme".
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Adolph, W.H.; Wang, Y.L. (1934). "The Digestibility of Soybean Milk Compared with Cow's Milk in Vitro and in Vivo".
1338: 1170: 613:: "The top class of virtue is like water, which benefits ten thousand objects without any demands for return." 2150: 1857: 1787: 2353: 1792: 409: 183: 120: 2248: 915:
Levenbok, L.; Wang, Y.L. (1948). "Succinic Acid in the Blood of the Larva of Gastro philus Intestinalis".
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that "we were like the proverbial hare which took a long nap while others were not like the tortoise".
510:. He was unable to conduct research for most of the ten years. During an interview in 1986, Wang told 2399: 2394: 1807: 1664: 924: 2203: 2022: 2017: 1832: 2348: 2273: 2238: 2208: 2085: 2002: 1992: 1912: 1887: 1777: 1772: 577: 503: 416:. After obtaining his Ph.D. in 1941, Wang stayed to teach at Cambridge and conduct research at the 2368: 2338: 2298: 2263: 2223: 2170: 2165: 2130: 2105: 2032: 1977: 1932: 1310: 354: 2308: 2258: 2228: 2218: 2198: 2140: 2037: 2012: 1922: 1892: 1847: 1827: 1802: 1762: 1669: 948: 786: 507: 2358: 2313: 2288: 2160: 2120: 2080: 2065: 1982: 1967: 1962: 1947: 1902: 1133:
Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch
472: 2318: 2243: 2095: 2075: 2070: 1987: 1852: 1837: 1401: 685:"Vitamin Methods 4A Potentiometric Method for the Estimation of Vitamin C in Coloured Extracts" 2293: 1882: 1629: 1382: 1272: 1241: 1223: 1093: 1085: 998: 940: 903: 829: 757: 714: 671: 512: 2323: 2135: 455:. In 1955, he was among the first group of scientists to be elected to the newly established 1957: 1734: 1372: 1231: 1215: 1075: 932: 893: 885: 819: 811: 778: 747: 739: 704: 696: 661: 653: 400: 286: 194: 1942: 1927: 445: 26: 1797: 769:
Keilin, D.; Wang, Y.L. (1945). "Haemoglobin from the Root Nodules of Leguminous Plants".
307: 928: 2343: 2155: 2027: 2007: 1724: 1236: 1203: 898: 873: 824: 799: 752: 727: 709: 684: 666: 641: 502:, believed Wang's total synthesis of insulin was worthy of a Nobel Prize. However, the 499: 433: 31: 2388: 2283: 2253: 2175: 1867: 1782: 1659: 1613: 1603: 1563: 1558: 1538: 1533: 1468: 1136: 495: 1260: 2328: 2110: 2090: 1917: 1752: 1729: 1714: 1704: 1699: 1694: 1644: 1639: 1634: 1608: 1528: 952: 854:
Moore, T.; Wang, Y.L. (1943). "The Fluorescence of the Tissues in Avitaminosis E".
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Wang returned to China at the end of World War II despite efforts by Keilin and
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Wang, Y.L. (1950). "The Effect of Bile Acids on Succinoxidase Activity".
596:). Liu worked as a teacher and started a kindergarten. She suffered from 104: 1503: 1483: 441: 368: 131: 889: 815: 743: 700: 657: 1080: 1063: 936: 782: 392: 388: 82: 78: 800:"The Haemoglobin of Gastrophilus Larvae Purification and Properties" 523:(tRNA), another significant biological molecule, in the late 1970s. 408:(Jinling University) and was admitted to the graduate school of the 379:
in 1958 and served as its director until his retirement in 1984.
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Wang died in Shanghai on 5 May 2001, aged 93. Academician
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Province on 13 November 1907, in the final years of the
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Special Achievement Award, Miami Winter Symposium (1988)
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in Beijing. They married and had two sons, Wang Jiahu (
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Founding members of the Chinese Academy of Sciences
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Archived from 444:, and later joined the Medical Institute of 59:Wang Yinglai at Cambridge University in 1938 2445:Members of the Chinese Academy of Sciences 1443: 1429: 1421: 277: 53: 37: 1376: 1259:Lin, Qi-Shui; Li, Bo-Liang (2001-02-01). 1235: 1079: 897: 823: 751: 708: 665: 607:eulogized Wang with a quotation from the 2405:Academics of the University of Cambridge 1290: 1288: 1286: 1057: 1055: 1053: 1193: 1191: 1189: 1187: 1049: 1261:"In Memory of Professor WANG Ying-Lai" 1123: 1121: 1119: 1117: 1115: 1113: 1111: 1109: 1107: 2415:Alumni of the University of Cambridge 1359:Whelan, William Joseph (2001-06-01). 1064:"Obituary: Wang Ying-lai (1907–2001)" 7: 2410:Academic staff of Nanjing University 1265:Acta Biochimica et Biophysica Sinica 1157: 1155: 1153: 856:Proc. Biochem. Soc., (Great Britain) 2470:Victims of the Cultural Revolution 461:Shanghai Institute of Biochemistry 377:Shanghai Institute of Biochemistry 188:Shanghai Institute of Biochemistry 14: 640:Harris, L.J.; Wang, Y.L. (1941). 1062:Wang, L. Ling-chi (2001-07-05). 580:, when he was recuperating from 412:in 1938, where he studied under 1361:"Appreciation of Ying-Lai Wang" 872:Keilin, D.; Wang, Y.L. (1947). 798:Keilin, D.; Wang, Y.L. (1946). 490:Many scientists, including the 359: 726:Moore, T.; Wang, Y.L. (1945). 459:. In 1958, he established the 350: 342: 313: 299: 269: 255: 1: 2450:Members of the Jiusan Society 1198:Zhang, Baoyuan; Xue, Pangao; 600:in old age and died in 1992. 2465:University of Nanking alumni 1169:. 2017-11-15. Archived from 130:Total chemical synthesis of 1019:Revue Roumaine de Biochemie 457:Chinese Academy of Sciences 438:National Central University 418:Dunn Nutritional Laboratory 373:Chinese Academy of Sciences 2486: 1378:10.1080/152165401753366078 843:Quart. J. Pharm. Pharmacol 20: 2460:People from Kinmen County 2455:Nanjing University alumni 1220:10.1007/s13238-011-1075-5 592: 586: 572: 328: 324: 276: 239: 235: 231: 162: 52: 47: 1400:Li, Hujun (2001-08-09). 420:. He transferred to the 383:Early life and education 375:in 1955. He founded the 250:Traditional Chinese 410:University of Cambridge 264:Simplified Chinese 184:University of Cambridge 121:University of Cambridge 2420:Biologists from Fujian 570:Wang met Liu Runling ( 2435:Educators from Fujian 617:Selected publications 560:Ho Leung Ho Lee Prize 556:William Joseph Whelan 498:and Physics laureate 406:University of Nanking 156:Ho Leung Ho Lee Prize 117:University of Nanking 2425:Chemists from Fujian 728:"Hypervitaminosis A" 2430:Chinese biochemists 929:1948Natur.162..731L 598:Alzheimer's disease 590:) and Wang Jianan ( 578:Yenching University 504:Cultural Revolution 347:traditional Chinese 2440:Hokkien scientists 1208:Protein & Cell 866:Brit. J. Nutrition 652:(8–9): 1050–1067. 508:Mao Zedong thought 339:simplified Chinese 16:Chinese biochemist 2382: 2381: 923:(4123): 731–732. 890:10.1042/bj0410491 816:10.1042/bj0400855 744:10.1042/bj0390222 701:10.1042/bj0360183 658:10.1042/bj0351050 513:The Straits Times 494:committee member 387:Wang was born in 332: 331: 320: 319: 287:Standard Mandarin 164:Scientific career 2477: 1735:Zhuang Changgong 1445: 1438: 1431: 1422: 1416: 1415: 1413: 1412: 1397: 1391: 1390: 1380: 1356: 1350: 1349: 1347: 1346: 1331: 1325: 1324: 1322: 1321: 1315: 1309:. Archived from 1304: 1292: 1281: 1280: 1256: 1250: 1249: 1239: 1195: 1182: 1181: 1179: 1178: 1159: 1148: 1147: 1145: 1144: 1135:. Archived from 1125: 1102: 1101: 1083: 1081:10.1038/35083684 1059: 1026: 1006: 982: 975:Chin. J. Physiol 969: 962:Chin. J. Physiol 956: 937:10.1038/162731b0 911: 901: 863: 850: 837: 827: 810:(5–6): 855–866. 794: 783:10.1038/155227a0 765: 755: 722: 712: 695:(1–2): 183–195. 679: 669: 633: 626:Chin. J. Physiol 595: 594: 589: 588: 576:), a student at 575: 574: 401:Overseas Chinese 361: 352: 344: 316: 315: 302: 301: 278: 272: 271: 258: 257: 206:Notable students 195:Doctoral advisor 100: 75:13 November 1907 74: 72: 57: 38: 2485: 2484: 2480: 2479: 2478: 2476: 2475: 2474: 2385: 2384: 2383: 2378: 2191: 2185: 2058: 2052: 1928:Sheng Tongsheng 1745: 1739: 1618: 1461: 1455: 1449: 1419: 1410: 1408: 1406:Nanfang Weekend 1399: 1398: 1394: 1358: 1357: 1353: 1344: 1342: 1333: 1332: 1328: 1319: 1317: 1313: 1302: 1294: 1293: 1284: 1258: 1257: 1253: 1197: 1196: 1185: 1176: 1174: 1161: 1160: 1151: 1142: 1140: 1129:"Wang Ying-Lai" 1127: 1126: 1105: 1061: 1060: 1051: 1047: 1042: 1016: 991:Scientia Sinica 988: 972: 959: 914: 871: 853: 840: 797: 768: 725: 682: 639: 623: 619: 568: 552: 471:(Zou Chenglu), 446:Academia Sinica 430: 385: 186: 154: 119: 113:Alma mater 108: 102: 98: 89: 76: 70: 68: 60: 43: 36: 17: 12: 11: 5: 2483: 2481: 2473: 2472: 2467: 2462: 2457: 2452: 2447: 2442: 2437: 2432: 2427: 2422: 2417: 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Index

Chinese name
family name
Wang

Kinmen
Fujian
Qing China
Shanghai
University of Nanking
University of Cambridge
insulin
tRNA
Ho Leung Ho Lee Prize
Biochemistry
University of Cambridge
Shanghai Institute of Biochemistry
Doctoral advisor
David Keilin
Li Zaiping
Xu Genjun
Hong Guofan
Liu Xinyuan
Wang Enduo
Traditional Chinese
Simplified Chinese
Standard Mandarin
Hanyu Pinyin
Wade–Giles
simplified Chinese
traditional Chinese

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