344:. Viruses that belong to this family are single stranded (-) RNA viruses that replicate within the nucleus of the host's cells. Influenza types A and B are routinely spread from human to human, and they are responsible for seasonal flu epidemics each year. Influenza type C virus causes mild respiratory infections and are not known to cause epidemics, unlike the other two. Barclay has worked intensively with Influenza A and Influenza B viruses for at least a decade. She has published many articles detailing the importance of understanding how influenza viruses interact with their hosts, understanding their
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In
January 2019, Wendy Barclay led an IdeasLab session at the World Economic Forum in Davos, Switzerland that focused on 'Developing a Vaccine Revolution', in which she spoke about the race to stop the next flu pandemic at source by preventing it from crossing from wild birds into chickens. Work with
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in 2010, and has been cited over 270 times. Research gathered for the article explained how one of the human cell's defences against RNA viruses comes in the form of RIG-Is. When a cell is infected with a RNA virus, RIG-I activation triggers an antiviral immune response. However, it was not fully
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and the influenza virus since her publication in 2006. She is trying to learn more about host range restrictions for the influenza virus, and its transmission between humans and animals as well as transmission between animal species. Barclay is also interested in studying influenza virus
315:. While at Reading, she learned many molecular virology skills that would help her to form the basis of her research career. At Mount Sinai, she was the first person to modify techniques for recovering recombinant influenza virus from cloned cDNA for the study of type B influenza virus.
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posted an article on its webpage that included statements made by
Barclay. In it she told of her concerns about another possible flu pandemic, and how, if it ever did happen, it would spread fast and hard.
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Rehwinkel, J; Ping, Choon; Goubau, Delphine; Schulz, Oliver; Pichlmair, Andreas; Bier, Katja; Robb, Nicole; Vreede, Frank; Barclay, Wendy; Fodor, Ervin; Reis, Caetano (5 February 2010).
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makeup, and understanding how different strains of the two viruses interact with host cells differently. She has also described some of the mechanisms of flu resistance to drugs.
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In addition, she has written articles describing the importance of understanding how some viruses can cross species barriers to prevent another epidemic. In
February 2015,
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At the start of her research career, Barclay worked with both rhinoviruses and various types of small RNA viruses. Barclay has worked mainly with the three types of virus:
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to discover novel vaccines. In particular, they are trying to understand more about influenza virus mutations, and how they can allow scientists to create new
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368:, which allow scientists to create new vaccines against possible influenza pandemics. She is particularly keen on understanding the resistance mechanisms of
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Barclay, Wendy S.; Lackenby, Angie; Zambon, Maria; Langat, Pinky; Fletcher, Robert A.; Velthuis, Aartjan J. W. te; Goldhill, Daniel H. (6 November 2018).
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committee member, Scientific
Programme Committee for Options for Control of Influenza, Options for Control of Influenza Conference, Cape Town, 2013
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known what part of the virus infection triggers RIG-I activation. Results of this study found that RIG-I activation is caused by the process of
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Committee member, Joint
Committee on Vaccination and Immunization (Influenza Sub-group), Joint Committee on Vaccination and Immunization,
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Invited Member of panel, The peer review panel for animal work on influenza, Conference on
Decision and Control (CDC) 2013, 2013 â 2013
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One of
Barclay's most notable work involved looking at cells infected with the influenza A virus and identifying physiological
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was titled "The humoral immune response to rhinovirus infection". At
Reading, she was involved in human challenge studies with
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1196:"Imperial scientists present vaccine revolution to world leaders at WEF in Davos | Imperial News | Imperial College London"
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compounds, and characterisation of novel cell substrates and attenuated virus backbones for influenza vaccines.
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and correspond to full-length virus genomes, or single-stranded RNA viral genomes bearing 5â˛-triphosphates.
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1020:"Transmission of a 2009 H1N1 Pandemic Influenza Virus Occurs before Fever Is Detected, in the Ferret Model"
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Barclay has been working on understanding and discovering more information about the relationship between
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World
Economic Forum, Davos, Switzerland 2018: IdeasLab session on Developing a Vaccine Revolution
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1105:"Variation in the ability of human influenza a viruses to induce and inhibit the IFN-β pathway"
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223:. She is currently head of Department of Infectious Disease and chair in Influenza Virology at
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Geoff Watts (1 June 2018). "Wendy
Barclay: a contagious enthusiasm for the influenza virus".
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Hayman, A; Comely, S; Lackenby, A; Murphy, S; McCauley, J; Goodbourn, S; Barclay, W (2006).
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Barclay, Wendy S.; Stuart M. Haslam; Mistry, Bhakti; Long, Jason S. (February 2019).
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Virus resistant animals to protect people against new outbreaks | Wendy Barclay
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994:"Flu virus can mutate to beat a new wonder drug, worried scientists reveal"
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focused on blocking this transmission using novel molecular techniques.
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870:"Host and viral determinants of influenza A virus species specificity"
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267:. For a postgraduate study, she conducted medical research at the
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BBC Future (Online) 2018 : Why the Flu of 1918 was so deadly
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Shelton, H; Stilwell, P; Barclay, W; Roberts, K (August 2012).
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Chair of the Virus Division, The Society For Microbiology, 2013
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1377:"New and Emerging Respiratory Virus Threats Advisory Group"
927:"The mechanism of resistance to favipiravir in influenza"
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New and Emerging Respiratory Virus Threats Advisory Group
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847:(3rd ed.). Washington, DC: ASM Press. p. 61.
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Flint, S; Enquist, L; Racaniello, V; Skalka, A (2009).
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positions. One was with Professor Jeff Almond at the
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The humoral immune response to rhinovirus infection
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The humoral immune response to rhinovirus infection
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521:(TV movie documentary), 2013; appeared as herself
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931:Proceedings of the National Academy of Sciences
227:. She leads a team of scientists studying the
1499:Commanders of the Order of the British Empire
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1082:"Are we ready for the next global epidemic?"
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428:Commander of the Order of the British Empire
411:Prize Lecture in Virology on the subject of
322:Influenza A virus â negative stain image TEM
275:and Fred Brown, for which she was awarded a
820:Centers for Disease Control and Prevention
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1327:(Supplement). 1 January 2022. p. N9.
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1080:Senthilingam, Meera (13 February 2015).
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1484:Alumni of the University of Cambridge
1171:"World Economic Forum Annual Meeting"
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727:(PhD thesis). University of Reading.
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1479:Academics of Imperial College London
1403:"Why the flu of 1918 was so deadly"
14:
1454:"Wendy Barclay and the flu virus"
992:Bagot, Martin (25 October 2018).
454:basic Science Interview Committee
338:. All three belong to the family
438:Memberships and editorial boards
417:Microbiology Society Prize Medal
395:. This article was published in
384:Notable work, honours and awards
299:After her PhD, Barclay held two
502:, member of the editorial board
494:, member of the editorial board
491:The Journal of General Virology
415:. and she was awarded the 2023
473:Barclay has served on several
133:Mount Sinai School of Medicine
1:
615:10.1016/S0140-6736(16)31113-8
1045:10.1371/journal.pone.0043303
816:"Types of Influenza Viruses"
567:publications indexed by the
271:in Salisbury, supervised by
1276:"Peter Wildy Prize Lecture"
1122:10.1016/j.virol.2005.11.024
874:Nature Reviews Microbiology
760:"Scientific Advisory Board"
530:, 2013; appeared as herself
103:Research of influenza virus
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1244:10.1016/j.cell.2010.01.020
717:Barclay, Wendy S. (1988).
547:, first broadcast in 2018.
445:Department of Health (DoH)
434:for services to virology.
309:Mount Sinai Medical Center
1352:"Professor Wendy Barclay"
887:10.1038/s41579-018-0115-z
662:"Professor Wendy Barclay"
255:Barclay graduated with a
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1494:British women scientists
1452:Al-Khalili, Jim (2018).
785:"Speaker: Wendy Barclay"
571:bibliographic database.
1356:Imperial College London
1280:microbiologysociety.org
1274:Society, Microbiology.
952:10.1073/pnas.1811345115
697:Imperial College London
666:Imperial College London
573:(subscription required)
307:, and the other was at
265:University of Cambridge
225:Imperial College London
129:Imperial College London
88:University of Cambridge
845:Principles of Virology
426:Barclay was appointed
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1504:Influenza researchers
1298:Microbiology Sociiety
588:Europe PubMed Central
432:2022 New Year Honours
407:In 2016 she gave the
321:
305:University of Reading
301:postdoctoral research
281:University of Reading
243:against possible flu
93:University of Reading
48:Wendy Barclay in 2019
1294:"Prize winners 2023"
1175:World Economic Forum
421:Microbiology Society
277:Doctor of Philosophy
1489:British virologists
1036:2012PLoSO...743303R
943:2018PNAS..11511613G
937:(45): 11613â11618.
540:The Life Scientific
295:Research and career
1324:The London Gazette
741:uk.bl.ethos.383380
668:. Imperial College
586:publications from
450:Committee member,
324:
16:British virologist
1509:Women virologists
854:978-1-55581-443-4
693:"News and Events"
507:Media appearances
402:viral replication
328:Influenza A virus
311:in New York with
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157:Academic advisors
109:Scientific career
58:Wendy Sue Barclay
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475:editorial boards
378:Roslin Institute
341:Orthomyxoviridae
336:Influenzavirus C
332:Influenzavirus B
269:Common Cold Unit
261:Natural Sciences
257:Bachelor of Arts
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533:Interviewed by
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285:doctoral thesis
279:(PhD) from the
259:(BA) degree in
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483:PLOS Pathogens
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25:Wendy Barclay
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1435:. Retrieved
1410:. Retrieved
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1115:(1): 52â64.
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125:Institutions
108:
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1407:www.bbc.com
1319:"No. 63571"
1303:26 November
764:Stabilitech
545:BBC Radio 4
519:Human Swarm
477:including:
409:Peter Wildy
74:Citizenship
64:Nationality
1468:Categories
791:. Elsevier
602:The Lancet
552:References
289:rhinovirus
237:morphology
233:physiology
221:virologist
164:Fred Brown
961:0027-8424
896:1740-1534
789:Epidemics
733:499917328
639:Q59357577
623:0140-6736
413:Influenza
370:antiviral
366:mutations
263:from the
251:Education
245:pandemics
229:influenza
180:.imperial
84:Education
1412:14 March
1386:20 March
1253:20144762
1205:14 March
1180:14 March
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1055:3430703
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419:by the
346:genomic
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186:/people
173:Website
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1456:. BBC.
1437:11 May
1433:. IMDb
1381:GOV.UK
1361:11 May
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140:Thesis
115:Fields
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1084:. CNN
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795:3 May
769:3 May
737:EThOS
702:3 May
390:RIG-I
215:(nÊe
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90:(BA)
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1439:2015
1414:2019
1388:2020
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1207:2019
1182:2019
1158:2019
1127:PMID
1090:2015
1060:PMID
1005:2019
975:PMID
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900:PMID
892:ISSN
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771:2015
729:OCLC
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674:2015
627:PMID
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1117:doi
1113:347
1050:PMC
1040:doi
965:PMC
947:doi
935:115
882:doi
611:doi
607:391
543:on
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178:www
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