160:
146:, but they didn't demonstrate clinical efficiency. Interferons alpha and beta administered intranasally before virus challenge were effective as prophylactic agents, but they were most effective in prophylaxis rather than treatment and had local side effects so they subsequently were not used in the routine practice against common cold viruses. Research made by the Common Cold Unit improved our understanding of respiratory viruses, their lifecycle and possible vaccines.
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with preparations of cold viruses and typically stayed for ten days. They were housed in small groups of two or three, with each group strictly isolated from the others during the course of the stay. Volunteers were allowed to go out for walks in the countryside south of
Salisbury, but residential
112:
refined these experiments at
Harvard Hospital in Salisbury, England. Around 1946 this hospital became the Common Cold Unit of the Medical Research Council. The Common Cold Research Unit was set up by the Medical Research Council after Dr. Andrewes promoted the idea of researches on volunteers and
103:
Our current understanding of colds began in 1914 when Dr. Kruse showed that nasal secretions from people with colds could be filtrated to make them free from bacteria and that inoculation of those filtrated washes into the nose of recipients caused the same illness.
71:
Thirty volunteers were required every fortnight during trial periods. The unit advertised in newspapers and magazines for volunteers, who were paid a small amount. A stay at the unit was presented in these advertisements as an unusual holiday opportunity. The
141:
For 43 years of Common Cold Unit existence thousands of volunteers participated in researches being inoculated with common cold viruses or being in control group, but no cure for the common cold has been found. Some compounds were active against rhinovirus
950:
84:, which are responsible for about 10% of common colds, were first isolated from volunteers at the unit in 1965. The CCU continually recruited volunteers for research into the common cold until its closure in 1990. The final director was
335:
47:
between 1946 and 1989 and produced 1,006 papers. The Common cold Unit studied etiology, epidemiology, prevention, and treatment of common colds. It was set up on the site of the
Harvard Hospital, a former
955:
343:
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at the Common Cold Unit. After washes were inoculated to volunteers and tested for known viruses none was found. Publication about first human coronavirus was published in
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imaged virus for the first time and group of eight virologists including June
Almeida named it coronavirus in their publication in 1968.
121:
The first coronavirus (B814) was found in washes from a boy with typical common cold symptoms in 1960 during the study led by virologist
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36:
813:"The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics"
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Lambkin-Williams, Rob; Noulin, Nicolas; Mann, Alex; Catchpole, Andrew; Gilbert, Anthony S. (22 June 2018).
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603:"The common cold--my favourite infection. The eighteenth Majority Stephenson memorial lecture"
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The CCU was sometimes confused with the
Microbiological Research Establishment at nearby
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756:"New treatments for viral respiratory tract infections—opportunities and problems"
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Former research units of the
Medical Research Council (United Kingdom)
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552:(online ed.). Oxford University Press. 23 September 2004.
88:, whose autobiography describes his work at the CCU from 1957.
648:"Covid-19: Coronavirus was first described in The BMJ in 1965"
153:
543:"Andrewes, Sir Christopher Howard (1896–1988), virologist"
429:"An Urgent Need for "Common Cold Units" to Study COVID-19"
336:"The Medical Research Council Common Cold Research Unit"
113:
persuaded authorities to set up the research station.
433:
The
American Journal of Tropical Medicine and Hygiene
64:and the economic costs are substantial in terms of
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956:Medical research institutes in the United Kingdom
704:"Cold Wars: The Fight against the Common Cold"
8:
991:1989 disestablishments in the United Kingdom
263:Cold Wars: The Fight against the Common Cold
981:Medical controversies in the United Kingdom
60:. Common colds account for a third of all
986:1946 establishments in the United Kingdom
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204:Learn how and when to remove this message
876:- a British Library oral history project
261:Tyrrell, David; Michael Fielder (2002).
167:This article includes a list of general
549:Oxford Dictionary of National Biography
365:
574:from the original on 18 September 2021
760:Journal of Antimicrobial Chemotherapy
265:. New York: Oxford University Press.
16:British Medical Research Council unit
7:
1001:Organizations disestablished in 1989
749:
747:
490:Journal of General Internal Medicine
646:Mahase, Elisabeth (16 April 2020).
427:Halstead, Scott B. (9 April 2020).
220:"A view from the Common Cold Unit"
173:it lacks sufficient corresponding
14:
996:Organizations established in 1946
961:Research institutes in Wiltshire
882:
702:Ellis, Harold (4 January 2003).
280:Richmond, Caroline (June 2005).
158:
874:History of the Common Cold Unit
607:The Journal of General Virology
39:which undertook laboratory and
976:British human subject research
754:Snell, N. J. C. (March 2001).
484:Lorber, Bennett (April 1996).
373:Oransky, Ivan (18 June 2005).
1:
609:. 68 ( Pt 8) (8): 2053–2061.
391:10.1016/S0140-6736(05)66722-0
971:Clinical trial organizations
708:BMJ: British Medical Journal
601:Tyrrell, D. A. (July 1987).
588:UK public library membership
236:10.1016/0166-3542(92)90032-Z
218:Tyrrell, D A J (June 1992).
62:acute respiratory infections
35:) was a unit of the British
652:BMJ (Clinical Research Ed.)
616:10.1099/0022-1317-68-8-2053
1022:
129:in 1965. Later virologist
77:areas were out of bounds.
830:10.1186/s12931-018-0784-1
720:10.1136/bmj.326.7379.57/a
375:"David Tyrrell, Obituary"
298:10.1136/bmj.330.7505.1451
282:"Obituary: David Tyrrell"
29:Common Cold Research Unit
316:"David Tyrrell obituary"
74:volunteers were infected
37:Medical Research Council
188:more precise citations.
558:10.1093/ref:odnb/40059
445:10.4269/ajtmh.20-0246
322:. London. 18 May 2005
52:at Harnham Down near
927:51.05333°N 1.80222°W
817:Respiratory Research
772:10.1093/jac/47.3.251
106:Christopher Andrewes
923: /
340:Ministry of Defence
932:51.05333; -1.80222
892:has a profile for
691:on 28 August 2021.
502:10.1007/BF02642480
416:on 28 August 2021.
346:on 26 October 2012
898:
895:Common Cold Unit
665:10.1136/bmj.m1547
586:(Subscription or
567:978-0-19-861412-8
486:"The common cold"
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1006:Common cold
930: /
350:17 February
326:17 February
186:introducing
117:Discoveries
93:Porton Down
45:common cold
945:Categories
897:(Q5153310)
823:(1): 123.
590:required.)
379:The Lancet
360:References
194:March 2020
169:references
66:sick leave
915:51°3′12″N
839:1465-993X
780:0305-7453
728:0959-8138
674:1756-1833
658:: m1547.
625:0022-1317
510:0884-8734
453:0002-9637
320:The Times
58:Wiltshire
54:Salisbury
966:Virology
918:1°48′8″W
857:29929556
798:11222557
682:32299810
572:Archived
471:32274988
407:43188254
399:16121448
144:in vitro
890:Scholia
848:6013893
789:7110210
737:1124964
633:3039038
528:8744881
519:7089473
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254:1329647
245:7133934
182:improve
150:Sources
137:Results
127:The BMJ
99:History
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80:Human
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853:PMID
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794:PMID
776:ISSN
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678:PMID
670:ISSN
629:PMID
621:ISSN
580:2021
562:ISBN
524:PMID
506:ISSN
467:PMID
449:ISSN
395:PMID
352:2008
328:2008
267:ISBN
250:PMID
108:and
33:CCRU
19:The
843:PMC
825:doi
784:PMC
768:doi
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554:doi
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294:doi
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286:BMJ
240:PMC
232:doi
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