20:
156:
scissors. The sections of the umbilical cord tissue that are devoid of arteries should then be fragmented into smaller fragments. These tissue fragments are subsequently placed in a sterile cell culture plate or cell culture flask, and the
96:. Wharton's jelly, when exposed to temperature changes, collapses structures within the umbilical cord and thus provides a physiological clamping of the cord, typically three minutes after birth.
447:
189:
marketing email from a company in
Arizona advertising a "3 for 1" sale on Exosomes or Whartons Jelly. The email stated that the products are "manufactured in an FDA-registered,
440:
19:
148:
After obtaining the umbilical cord from the donor, it is transported to the laboratory in a cold and sterile environment using a transfer buffer that contains
433:
648:
221:
243:
264:"Wharton's jelly-derived stromal cells and their cell therapy applications in allogeneic haematopoietic stem cell transplantation"
643:
326:
Ahangari, Fatemeh; Mirsanei, Zahra; Soudi, Sara; Khaligh, Sahar
Ghaffari; Soufi, Sara; Hashemi, Seyed Mahmoud (2023-10-03).
202:
328:"Isolation of Mesenchymal Stem Cells (MSCs) from Wharton's Jelly (WJ) Tissue of Human Umbilical Cord (hUC); a Protocol"
152:. Subsequently, the vessels should be eliminated from the umbilical cord tissue on a sterile plate with the aid of
133:
149:
485:
85:
51:
420:
612:
93:
607:
653:
480:
170:
47:
39:
513:
186:
173:
for a duration of 1-2 weeks. This process ultimately leads to the proliferation and migration of
162:
112:. They can be extracted, cultured, and induced to differentiate into mature cell types such as
388:
347:
293:
239:
197:
certified lab", but did not mention that such birth products can be used only in a registered
366:
553:
462:
378:
339:
283:
275:
117:
67:
622:
528:
509:
475:
43:
415:
617:
558:
548:
540:
502:
288:
263:
198:
79:
35:
327:
637:
89:
425:
523:
158:
140:, or "The Description of the Glands of the Entire Body", first published in 1656.
169:) is added. Lastly, the flask containing the tissue fragments is placed in a CO2
470:
59:
55:
410:
602:
383:
190:
166:
121:
109:
351:
492:
174:
153:
105:
392:
343:
297:
581:
63:
586:
497:
279:
113:
367:"Marketing of Unproven and Unapproved Regenerative Medicine Therapies"
518:
18:
421:
Cross-section microscopic slide views of umbilical cord ucsd.edu
429:
262:
Pochon C, Notarantonio AB, Laroye C, et al. (March 2022).
194:
313:
Adenographia: sive glandularum totius corporis descriptio
80:
Umbilical cord § Physiological postnatal occlusion
136:(1614–1673) who first described it in his publication
116:. Wharton's jelly is therefore a potential source of
132:
It is named for the
English physician and anatomist
595:
574:
539:
461:
201:, according to a directive from the United States
177:from the Wharton's jelly into the plate or flask.
238:(11th ed.). Wolters Kluwer. p. 105.
16:Gelatinous substance within the umbilical cord
441:
8:
448:
434:
426:
268:Journal of Cellular and Molecular Medicine
224:in the Merriam-Webster Medical Dictionary.
382:
287:
104:Cells in Wharton's jelly express several
32:substantia gelatinea funiculi umbilicalis
214:
34:) is a gelatinous substance within the
62:, and is derived from extra-embryonic
7:
332:School of Medicine Students' Journal
257:
255:
315:. London: Wharton. pp. 243–44.
14:
456:Membranes of the fetus and embryo
23:Wharton's jelly - trichrome stain
144:Isolation of stem cells protocol
150:phosphate buffered saline (PBS)
1:
185:A 2024 editorial described a
92:, and protects and insulates
649:Animal developmental biology
236:Langman's Medical Embryology
203:Food and Drug Administration
670:
77:
384:10.1177/19417381241243380
486:Intermediate trophoblast
86:mucous connective tissue
74:Umbilical cord occlusion
52:mucous connective tissue
644:Reproduction in mammals
120:, often collected from
94:umbilical blood vessels
344:10.22037/smsj.v5.42169
161:medium (enriched with
24:
78:Further information:
38:, largely made up of
22:
613:Reichert's membrane
481:Syncytiotrophoblast
48:chondroitin sulfate
40:mucopolysaccharides
514:Intervillous space
280:10.1111/jcmm.17105
234:Sadler, T (2010).
187:direct-to-consumer
163:fetal bovine serum
25:
631:
630:
608:Heuser's membrane
365:Rodeo SA (2024).
311:Warton T (1656).
205:on May 31, 2021.
108:genes, including
661:
554:Umbilical artery
450:
443:
436:
427:
397:
396:
386:
362:
356:
355:
323:
317:
316:
308:
302:
301:
291:
274:(5): 1339–1350.
259:
250:
249:
231:
225:
219:
118:adult stem cells
88:, it is rich in
68:connecting stalk
54:containing some
50:). It acts as a
669:
668:
664:
663:
662:
660:
659:
658:
634:
633:
632:
627:
623:Gestational sac
591:
570:
564:Wharton's jelly
535:
510:Chorionic villi
476:Cytotrophoblast
457:
454:
406:
401:
400:
364:
363:
359:
325:
324:
320:
310:
309:
305:
261:
260:
253:
246:
233:
232:
228:
222:Wharton's jelly
220:
216:
211:
183:
146:
130:
102:
82:
76:
44:hyaluronic acid
28:Wharton's jelly
17:
12:
11:
5:
667:
665:
657:
656:
651:
646:
636:
635:
629:
628:
626:
625:
620:
618:Vitelline duct
615:
610:
605:
599:
597:
593:
592:
590:
589:
584:
578:
576:
572:
571:
569:
568:
567:
566:
561:
559:Umbilical vein
556:
549:Umbilical cord
545:
543:
537:
536:
534:
533:
532:
531:
526:
516:
507:
506:
505:
503:Decidual cells
495:
490:
489:
488:
483:
478:
467:
465:
459:
458:
455:
453:
452:
445:
438:
430:
424:
423:
418:
405:
404:External links
402:
399:
398:
377:(3): 312–314.
357:
318:
303:
251:
244:
226:
213:
212:
210:
207:
199:clinical trial
182:
179:
145:
142:
134:Thomas Wharton
129:
126:
101:
98:
75:
72:
36:umbilical cord
15:
13:
10:
9:
6:
4:
3:
2:
666:
655:
652:
650:
647:
645:
642:
641:
639:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
600:
598:
594:
588:
585:
583:
580:
579:
577:
573:
565:
562:
560:
557:
555:
552:
551:
550:
547:
546:
544:
542:
538:
530:
527:
525:
522:
521:
520:
517:
515:
511:
508:
504:
501:
500:
499:
496:
494:
491:
487:
484:
482:
479:
477:
474:
473:
472:
469:
468:
466:
464:
460:
451:
446:
444:
439:
437:
432:
431:
428:
422:
419:
417:
416:Who Named It?
413:
412:
408:
407:
403:
394:
390:
385:
380:
376:
372:
371:Sports Health
368:
361:
358:
353:
349:
345:
341:
337:
333:
329:
322:
319:
314:
307:
304:
299:
295:
290:
285:
281:
277:
273:
269:
265:
258:
256:
252:
247:
245:9780781790697
241:
237:
230:
227:
223:
218:
215:
208:
206:
204:
200:
196:
192:
188:
180:
178:
176:
172:
168:
164:
160:
155:
151:
143:
141:
139:
135:
127:
125:
123:
119:
115:
111:
107:
99:
97:
95:
91:
90:proteoglycans
87:
81:
73:
71:
69:
65:
61:
57:
53:
49:
45:
41:
37:
33:
29:
21:
563:
409:
374:
370:
360:
335:
331:
321:
312:
306:
271:
267:
235:
229:
217:
184:
159:cell culture
147:
138:Adenographia
137:
131:
103:
83:
31:
27:
26:
575:Circulatory
471:Trophoblast
193:compliant,
167:antibiotics
60:macrophages
56:fibroblasts
654:Embryology
638:Categories
603:Blastocoel
209:References
175:stem cells
154:autoclaved
122:cord blood
110:telomerase
100:Stem cells
493:Allantois
411:synd/2298
352:2676-7597
181:Marketing
171:incubator
128:Etymology
106:stem cell
582:Placenta
393:38629755
298:35088933
64:mesoderm
587:Chorion
498:Decidua
289:8899189
114:neurons
66:of the
529:cavity
519:Amnion
463:Embryo
391:
350:
296:
286:
242:
596:Other
541:Fetus
84:As a
389:PMID
348:ISSN
294:PMID
240:ISBN
191:cGMP
165:and
58:and
46:and
524:sac
414:at
379:doi
340:doi
284:PMC
276:doi
195:ISO
640::
387:.
375:16
373:.
369:.
346:.
338:.
334:.
330:.
292:.
282:.
272:26
270:.
266:.
254:^
124:.
70:.
512:/
449:e
442:t
435:v
395:.
381::
354:.
342::
336:5
300:.
278::
248:.
42:(
30:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
