276:
53:
291:(WT1) or Wilms Tumor 2 (WT2) genes, and the tumor presents with a group of other signs and symptoms. Non-syndromic Wilms' tumor is not associated with other symptoms or pathologies. Many, but not all, cases of Wilms' tumor develop from nephrogenic rests, which are fragments of tissue in or around the kidney that develop before birth and become cancerous after birth. In particular, cases of bilateral Wilms' tumor, as well as cases of Wilms' tumor derived from certain genetic syndromes such as
268:
295:, are strongly associated with nephrogenic rests. Most nephroblastomas are on one side of the body only and are found on both sides in less than 5% of cases, although people with Denys-Drash syndrome mostly have bilateral or multiple tumors. They tend to be encapsulated and vascularized tumors that do not cross the midline of the abdomen. In cases of
1332:
van den Heuvel-Eibrink, Marry M.; Hol, Janna A.; Pritchard-Jones, Kathy; van
Tinteren, Harm; Furtwängler, Rhoikos; Verschuur, Arnauld C.; Vujanic, Gordan M.; Leuschner, Ivo; Brok, Jesper; Rübe, Christian; Smets, Anne M.; Janssens, Geert O.; Godzinski, Jan; Ramírez-Villar, Gema L.; de Camargo, Beatriz
723:
Tumor-specific loss-of-heterozygosity (LOH) for chromosomes 1p and 16q identifies a subset of Wilms' tumor patients who have a significantly increased risk of relapse and death. LOH for these chromosomal regions can now be used as an independent prognostic factor together with disease stage to target
2040:
Messahel B, Williams R, Ridolfi A, A'hern R, Warren W, Tinworth L, Hobson R, Al-Saadi R, Whyman G, Brundler MA, Kelsey A, Sebire N, Jones C, Vujanic G, Pritchard-Jones K (March 2009). "Allele loss at 16q defines poorer prognosis Wilms tumour irrespective of treatment approach in the UKW1-3 clinical
703:
5% of Wilms' tumor cases at the time of initial diagnosis are bilateral involvements, which pose unique challenges to treatment. An attempt should be made to stage each side according to the above criteria (stage I to III) on the basis of extent of disease prior to biopsy. Bilateral Wilms' tumors
1753:
Coorens THH, Treger TD, Al-Saadi R, Moore L, Tran MGB, Mitchell TJ, Tugnait S, Thevanesan C, Young MD, Oliver TRW, Oostveen M, Collord G, Tarpey PS, Cagan A, Hooks Y, Brougham M, Reynolds BC, Barone G, Anderson J, Jorgensen M, Burke GAA, Visser J, Nicholson JC, Smeulders N, Mushtaq I, Stewart GD,
1104:
Wilms' tumor affects approximately one person per 10,000 worldwide before the age of 15 years. People of
African descent may have slightly higher rates of Wilms' tumor. The peak age of Wilms' tumor is 3 to 4 years and most cases occur before the age of 10 years. A genetic predisposition to Wilms'
561:
The majority of people with Wilms' tumor present with an asymptomatic abdominal mass which is noticed by a family member or healthcare professional. Renal tumors can also be found during routine screening in children who have known predisposing clinical syndromes. The diagnostic process includes
215:
Approximately 650 cases are diagnosed in the U.S. annually. The majority of cases occur in children with no associated genetic syndromes; however, a minority of children with Wilms' tumor have a congenital abnormality. It is highly responsive to treatment, with about 90 percent of children
1100:
Wilms tumor is the most common malignant renal tumor in children. There are a number of rare genetic syndromes that have been linked to an increased risk of developing Wilms Tumor. Screening guidelines vary between countries; however health care professionals are recommending regular ultrasound
2004:
Tournade MF, Com-Nougué C, de Kraker J, Ludwig R, Rey A, Burgers JM, Sandstedt B, Godzinski J, Carli M, Potter R, Zucker JM (January 2001). "Optimal duration of preoperative therapy in unilateral and nonmetastatic Wilms' tumor in children older than 6 months: results of the Ninth
International
1282:
Fitski, Matthijs; van de Ven, Cornelis P.; Hulsker, Caroline C. C.; Bökkerink, Guus M. J.; Terwisscha van
Scheltinga, Cecilia E. J.; van den Heuvel-Eibrink, Marry M.; Mavinkurve-Groothuis, Annelies M. C.; van Grotel, Martine; Wijnen, Marc H. W. A.; Klijn, Aart J.; van der Steeg, Alida F. W.
1120:, founder of Dana–Farber Cancer Institute, and his colleagues achieved the first remissions in Wilms' tumor in the 1950s. By employing the antibiotic actinomycin D in addition to surgery and radiation therapy, they boosted cure rates from 40 to 89 percent.
1754:
Campbell PJ, Wedge DC, Martincorena I, Rampling D, Hook L, Warren AY, Coleman N, Chowdhury T, Sebire N, Drost J, Saeb-Parsy K, Stratton MR, Straathof K, Pritchard-Jones K, Behjati S (2019) Embryonal precursors of Wilms tumor. Science 366(6470):1247-1251
545:
1131:, an Italian physician. He discovered that in the direct radiograms and in the urographic images, you can identify determining elements for a differential diagnosis with the Wilms' tumor. This possibility was a premise for starting a treatment.
2487:
2472:
1541:
Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH (February 1990). "Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus".
1960:
Stewénius Y, Jin Y, Øra I, de Kraker J, Bras J, Frigyesi A, Alumets J, Sandstedt B, Meeker AK, Gisselsson D (November 2007). "Defective chromosome segregation and telomere dysfunction in aggressive Wilms' tumors".
2383:
Pritchard-Jones K, Fleming S, Davidson D, Bickmore W, Porteous D, Gosden C, Bard J, Buckler A, Pelletier J, Housman D (July 1990). "The candidate Wilms' tumour gene is involved in genitourinary development".
271:
Cut section showing two halves of a nephroblastoma specimen. Note the prominent septa subdividing the sectioned surface and the protrusion of tumor into the renal pelvis, resembling botryoid rhabdomyosarcoma.
2157:
Spreafico F, Pritchard Jones K, Malogolowkin MH, Bergeron C, Hale J, de Kraker J, Dallorso S, Acha T, de
Camargo B, Dome JS, Graf N (December 2009). "Treatment of relapsed Wilms tumors: lessons learned".
1447:
Guaragna MS, Soardi FC, Assumpção JG, Zambaldi L, Cardinalli IA, Yunes JA, de Mello MP, Brandalise SR, Aguiar S (August 2010). "The novel WT1 gene mutation p.H377N associated to Denys-Drash syndrome".
2080:, Li S, Perlman E, Beckwith JB, Ritchey ML, Shamberger RC, Haase GM, D'Angio GJ, Donaldson M, Coppes MJ, Malogolowkin M, Shearer P, Thomas PR, Macklis R, Tomlinson G, Huff V, Green DM (October 2005).
279:
Low magnification micrograph of a Wilms' tumor infiltrating the renal parenchyma. It shows the characteristic triphasic pattern consisting of tubules, solid sheets of small round cells, and stroma.
597:
findings and tumor cells pathology. According to the extent of tumor tissue at the time of initial diagnosis, four stages are considered, with a fifth classification for bilateral involvement.
550:
548:
2902:
549:
2247:
Kalish JM, Doros L, Helman LJ, Hennekam RC, Kuiper RP, Maas SM, Maher ER, Nichols KE, Plon SE, Porter CC, Rednam S, Schultz KA, States LJ, Tomlinson GE, Zelley K, Druley TE (July 2017).
3435:
695:
Stage IV (10% of cases) Wilms' tumor is defined by the presence of hematogenous metastases (lung, liver, bone, or brain), or lymph node metastases outside the abdominopelvic region.
287:
Wilms' tumor has many causes, which can broadly be categorized as syndromic and non-syndromic. Syndromic causes of Wilms' tumor occur as a result of alterations to genes such as the
2502:
3455:
331:, stromal and epithelial derivatives. Characteristic is the presence of abortive tubules and glomeruli surrounded by a spindled cell stroma. The stroma may include striated
1400:
Erginel B, Vural S, Akın M, Karadağ CA, Sever N, Yıldız A. et al (2014) Wilms' tumor: a 24-year retrospective study from a single center. Pediatr
Hematol Oncol 31: 409–414
2082:"Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study Group"
731:
Statistics may sometimes show more favorable outcomes for more aggressive stages than for less aggressive stages, which may be caused by more aggressive treatment and/or
547:
303:
and peritoneal dissemination of the tumor. In such cases, surgical intervention by a surgeon who is experienced in the removal of such a fragile tumor is imperative.
2895:
2656:
3586:
2888:
1016:
Preoperative treatment with regimen I followed by nephrectomy + lymph node sampling followed by abdominal radiotherapy, whole-lung radiotherapy
3571:
1285:"Patient-specific hydrogel phantoms for the preoperative simulation of nephron-sparing surgery in Wilms' tumor patients: A feasibility study"
1086:, followed by nephron sparing surgery or nephrecomy, staging of tumors, and chemotherapy and/or radiotherapy based on pathology and staging
1068:, followed by nephron sparing surgery or nephrecomy, staging of tumors, and chemotherapy and/or radiotherapy based on pathology and staging
1050:, followed by nephron sparing surgery or nephrecomy, staging of tumors, and chemotherapy and/or radiotherapy based on pathology and staging
3256:
3103:
2869:
593:
Staging is a standard way to describe the extent of spread of Wilms' tumors and to determine prognosis and treatments. Staging is based on
546:
2941:
2513:
1598:
735:
in the study groups. Also, a stage V tumor is not necessarily worse than, but nevertheless comparable in prognosis to a stage IV tumor.
275:
573:
can also be used for more detailed imaging. Finally, the diagnosis of Wilms' tumor is confirmed by a tissue sample. In most cases, a
3018:
1509:
2606:
3507:
2729:
2649:
1145:
1705:
Dome JS, Graf N, Geller JI, Fernandez CV, Mullen EA, Spreafico F, Van den Heuvel-Eibrink M, Pritchard-Jones K (September 2015).
491:
3275:
2986:
486:
Characterized by kidney diseases since birth leading to early-onset kidney failure, ambiguous genitalia (intersex disorders).
3051:
3033:
1270:
1092:
In case of relapse of Wilms' tumor, the 4-year survival rate for children with a standard-risk has been estimated to be 80%.
1262:
2249:"Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma"
988:
Nephrectomy + lymph node sampling, followed by abdominal radiotherapy, bilateral pulmonary radiotherapy, and regimen DD-4A
974:
Nephrectomy + lymph node sampling, followed by abdominal radiotherapy, bilateral pulmonary radiotherapy, and regimen DD-4A
3149:
3056:
1180:
565:
Once Wilms' tumor is suspected, an ultrasound scan is usually done first to confirm the presence of an intrarenal mass. A
3450:
3440:
3161:
594:
577:
is not done first because there is a risk of cancer cells spreading during the procedure. Treatment in North
America is
2443:
Nephroblastoma in childhood: current possibilities for an early radiographic diagnosis, Italian
Journal of Surgery 1969
1002:
Immediate nephrectomy + lymph node sampling followed by abdominal radiotherapy, whole-lung radiotherapy, and regimen I
684:
The tumor has been biopsied prior to removal or there is local spillage of tumor during surgery, confined to the flank.
3098:
2838:
2810:
2642:
1936:
1821:
585:
followed by nephrectomy. A definitive diagnosis is obtained by pathological examination of the nephrectomy specimen.
465:(one side of body larger than the other), genitourinary abnormalities, ambiguous genitalia, intellectual disability.
3566:
3378:
2956:
2765:
2140:
929:
Preoperative treatment with regimen DD-4A followed by nephrectomy + lymph node sampling and abdominal radiotherapy
570:
52:
3502:
3390:
3171:
2760:
2624:
2144:
724:
intensity of treatment to risk of treatment failure. Genome-wide copy number and LOH status can be assessed with
470:
399:. In addition at least half of the Wilms' tumors with mutations in WT1 also carry acquired somatic mutations in
343:, fat tissue, and fibrous tissue. Dysfunction is caused when the tumor compresses the normal kidney parenchyma.
3041:
2527:
1621:
943:
Preoperative treatment with regimen I followed by nephrectomy + lymph node sampling and abdominal radiotherapy
3487:
2615:
3469:
3227:
3071:
3013:
2965:
2843:
2815:
2770:
1887:
681:
Tumor spillage involving peritoneal surfaces either before or during surgery, or transected tumor thrombus.
562:
taking a medical history, a physical exam, and a series of tests including blood, urine, and imaging tests.
2336:"Age distributions, birth weights, nephrogenic rests, and heterogeneity in the pathogenesis of Wilms tumor"
1214:
752:
3576:
3305:
3156:
3113:
3108:
716:
is estimated to be approximately 90%, but for individuals the prognosis is highly dependent on individual
756:
3581:
732:
3492:
3337:
3061:
2991:
2724:
2696:
2393:
328:
292:
1653:"Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors"
3482:
3408:
3290:
3090:
3066:
3028:
3023:
2936:
2744:
2491:
1128:
554:
2620:
1911:
3445:
3420:
3383:
3280:
3249:
3213:
3046:
2820:
2417:
2226:
2183:
1986:
1792:
1567:
1523:
1472:
1372:
1314:
529:
283:. The surrounding renal parenchyma is more eosinophilic (pink) than the rather grey tumor stroma.
353:
Wilms' tumors may be separated into two prognostic groups based on pathologic characteristics:
346:
The mesenchymal component may include cells showing rhabdomyoid differentiation or malignancy (
3545:
3517:
3425:
3285:
3076:
2911:
2792:
2578:
2538:
2409:
2365:
2316:
2278:
2218:
2175:
2103:
2058:
2022:
1978:
1869:
1774:
1736:
1682:
1633:
1602:
1559:
1515:
1505:
1464:
1424:
1364:
1356:
1306:
1156:
725:
654:
Tumor involvement of the blood vessels of the renal sinus and/or outside the renal parenchyma.
396:
112:
2880:
2201:
Sonn G, Shortliffe LM (October 2008). "Management of Wilms tumor: current standard of care".
1707:"Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration"
1417:"Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®): Health Professional Version"
957:
Immediate nephrectomy + lymph node sampling followed by abdominal radiotherapy and regimen I
3374:
3270:
3208:
3144:
2701:
2634:
2401:
2355:
2347:
2308:
2268:
2260:
2210:
2167:
2093:
2050:
2014:
1970:
1859:
1851:
1726:
1718:
1672:
1664:
1594:
1551:
1497:
1456:
1346:
1296:
1151:
763:
347:
81:
2629:
1770:
Wilms Tumor and Other
Childhood Kidney Tumors Treatment (PDQ®): Health Professional Version
3361:
3189:
2830:
2784:
2739:
1804:
1238:
1140:
713:
507:
462:
2397:
1855:
3522:
3512:
3430:
3415:
3350:
3261:
3199:
3179:
2848:
2802:
2734:
2673:
2669:
2507:
2360:
2335:
2273:
2248:
1864:
1839:
1731:
1706:
1677:
1652:
1127:
for the diagnosis of Wilms' tumor began in the early 1970s, thanks to the intuition of
915:
Nephrectomy + lymph node sampling followed by abdominal radiotherapy and regimen DD-4A
746:
741:
387:(11p13) are observed in approximately 20% of Wilms' tumors, the majority of them being
2496:
252:
in some cases (especially if synchronous or metachronous bilateral kidney involvement)
3560:
2681:
2187:
1555:
1476:
1335:"Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol"
1318:
1117:
777:
Favorable histology in children younger than 24 months or tumor weight less than 550g
617:
533:
434:
384:
288:
2230:
1990:
1571:
1527:
605:
In Stage I Wilms' tumor (43% of cases), all of the following criteria must be met:
3540:
3184:
3086:
3005:
2978:
2946:
2589:
2421:
1376:
828:
791:
Favorable histology in children older than 24 months or tumor weight more than 550g
582:
515:
503:
408:
404:
249:
2299:
Breslow N, Olshan A, Beckwith JB, Green DM (1993). "Epidemiology of Wilms tumor".
2264:
1974:
1491:
280:
208:), and occurs most commonly as a renal tumor in child patients. It is named after
65:
2532:
1460:
1389:
898:
Nephrectomy + lymph node sampling followed by abdominal radiotherapy and regimen
861:
Nephrectomy + lymph node sampling followed by abdominal radiotherapy and regimen
299:
it is usually to the lung. A rupture of Wilms' tumor puts the patient at risk of
17:
3532:
3370:
3244:
3239:
3139:
2915:
2711:
2573:
1185:
800:
578:
511:
2592:
2054:
1768:
1501:
1416:
1301:
1284:
668:
In Stage III (20% of cases), 1 or more of the following criteria must be met:
3477:
3326:
2543:
2077:
2018:
812:
641:
In Stage II (23% of cases), 1 or more of the following criteria must be met:
525:
364:
321:
315:
300:
296:
256:
125:
61:
2098:
2081:
1722:
1360:
1310:
3403:
3346:
3295:
2584:
2549:
2481:
1351:
1334:
879:
336:
243:
209:
173:
150:
2369:
2312:
2282:
2222:
2179:
2107:
2062:
2026:
1982:
1873:
1778:
1740:
1686:
1637:
1599:
10.1002/(SICI)1096-8628(19981002)79:4<260::AID-AJMG6>3.0.CO;2-Q
1519:
1468:
1428:
1368:
2413:
2320:
1606:
1563:
786:
Surgery only (should be done only within the context of a clinical trial)
2918:
2853:
2665:
1109:
has been established, due to deletions in the p13 band on chromosome 11.
1106:
878:
Nephrectomy + lymph node sampling followed by abdominal radiotherapy and
458:
392:
388:
310:
117:
1622:"Frequent association of beta-catenin and WT1 mutations in Wilms tumors"
623:
The tumor is not ruptured or biopsied (open or needle) prior to removal.
267:
3001:
2974:
2922:
2214:
2171:
1124:
566:
121:
2464:
2351:
1668:
3235:
3135:
3127:
2610:
2476:
2405:
610:
574:
400:
332:
306:
Pathologically, a triphasic nephroblastoma comprises three elements:
197:
193:
168:
3322:
2554:
1083:
1065:
1047:
899:
862:
824:
804:
543:
274:
266:
224:
Typical signs and symptoms of Wilms' tumor include the following:
205:
201:
626:
No involvement of extrarenal or renal sinus lymph-vascular spaces
2521:
2518:
2334:
Breslow NE, Beckwith JB, Perlman EJ, Reeve AE (September 2006).
1266:
648:
No residual tumor apparent at or beyond the margins of excision.
448:
340:
2884:
2638:
2041:
trials: a
Children's Cancer and Leukaemia Group (CCLG) Study".
2294:
2292:
1490:
Popov, Sergey D.; Sebire, Neil J.; Vujanic, Gordan M. (2016).
476:
442:
379:
2005:
Society of Pediatric Oncology Wilms' Tumor Trial and Study".
847:
Nephrectomy + lymph node sampling followed by regimen EE-4A
2434:
Mukherjee, Siddhartha, The Emperor of All Maladies, pg. 123
645:
Tumor extends beyond the kidney but is completely excised.
629:
No residual tumor apparent beyond the margins of excision.
1215:"Wilms Tumor and Other Childhood Kidney Tumors Treatment"
212:, the German surgeon (1867–1918) who first described it.
87:
2139:
Unless otherwise specified in boxes, then reference is:
1101:
screening for people with associated genetic syndromes.
510:(one side of the body is larger), other tumors in body,
437:(Wilms tumor, aniridia, genital anomalies, retardation)
414:
Most cases do not have mutations in any of these genes.
657:
Extensive tumor involvement of renal sinus soft tissue.
3436:
Multiple cutaneous and uterine leiomyomatosis syndrome
2616:
GeneReviews/NCBI/NIH/UW entry on Wilms' Tumor Overview
823:
Nephrectomy + lymph node sampling followed by regimen
557:
of 11 cm Wilms' tumor of right kidney in 13-month-old.
1838:
Szychot E, Apps J, Pritchard-Jones K (January 2014).
1822:"Presentation, diagnosis, and staging of Wilms tumor"
368:– Contains diffuse anaplasia (poorly developed cells)
96:
2454:
1493:
Wilms' Tumour – Histology and Differential Diagnosis
720:. Early removal tends to promote positive outcomes.
360:– Contains well developed components mentioned above
90:
84:
3531:
3468:
3359:
3335:
3313:
3304:
3226:
3198:
3170:
3126:
3085:
3000:
2973:
2964:
2955:
2929:
2862:
2829:
2801:
2783:
2753:
2710:
2689:
2680:
2564:
2458:
167:
159:
149:
139:
131:
111:
93:
72:
40:
35:
1620:Maiti S, Alam R, Amos CI, Huff V (November 2000).
632:Metastasis of tumor to lymph nodes not identified.
1651:Ruteshouser EC, Robinson SM, Huff V (June 2008).
1840:"Wilms' tumor: biology, diagnosis and treatment"
1767:PDQ Pediatric Treatment Editorial Board (2002).
1415:PDQ Pediatric Treatment Editorial Board (2002),
651:Any of the following conditions may also exist:
1585:Huff V (October 1998). "Wilms tumor genetics".
502:Characterized by macrosmia (large birth size),
2896:
2650:
2242:
2240:
2135:
2133:
2131:
2129:
2127:
2125:
2123:
2121:
2119:
2117:
728:of tumor cells (fresh or paraffin-embedded).
327:Wilms' tumor is a malignant tumor containing
8:
1937:"Treatment by type and stage of Wilms tumor"
1209:
1207:
1205:
1203:
1175:
1173:
407:. This latter gene is found on short arm of
64:showing the three elements of Wilms' tumor.
1700:
1698:
1696:
1007:Diffuse anaplastic (preoperative treatment)
163:~500 new diagnoses per year (United States)
3310:
2970:
2961:
2903:
2889:
2881:
2686:
2657:
2643:
2635:
2455:
803:+ lymph node sampling followed by regimen
496:Abnormal regulation of chromosome 11p15.5
383:gene which is located on the short arm of
32:
2359:
2272:
2097:
1863:
1730:
1676:
1350:
1300:
920:Focal anaplastic (preoperative treatment)
1449:Journal of Pediatric Hematology/Oncology
737:
518:(enlargement of organs inside abdomen).
416:
373:Molecular biology and related conditions
1169:
403:, the gene encoding the proto-oncogene
1800:
1790:
1833:
1831:
1816:
1814:
1762:
1760:
678:Tumor is present at surgical margins.
7:
1587:American Journal of Medical Genetics
1410:
1408:
1406:
1082:Preoperative treatment with regimen
1064:Preoperative treatment with regimen
1046:Preoperative treatment with regimen
27:Rare childhood cancer of the kidneys
2942:Desmoplastic small-round-cell tumor
2630:Cancer.Net Wilms' Tumor – Childhood
2160:Expert Review of Anticancer Therapy
1856:10.3978/j.issn.2224-4336.2014.01.09
1239:"Wilms tumor: MedlinePlus Genetics"
228:a painless, palpable abdominal mass
1912:"Wilms Tumor - Childhood - Stages"
1773:. National Cancer Institute (US).
1423:, National Cancer Institute (US),
704:are as a whole placed in Stage V.
25:
3019:Aggressive infantile fibromatosis
2690:Glandular and epithelial neoplasm
2203:Nature Clinical Practice. Urology
440:Gene deletion that includes both
3587:Diseases named after discoverers
3508:Clear-cell sarcoma of the kidney
2730:Clear-cell sarcoma of the kidney
1421:PDQ Cancer Information Summaries
1146:National Wilms Tumor Study Group
395:, while a minority are acquired
80:
51:
3276:Intradermal spindle cell lipoma
2987:Dermatofibrosarcoma protuberans
1657:Genes, Chromosomes & Cancer
3104:Malignant fibrous histiocytoma
3052:Infantile digital fibromatosis
3038:Familial myxovascular fibromas
3034:Diffuse infantile fibromatosis
2870:Malignant fibrous histiocytoma
2301:Medical and Pediatric Oncology
1271:Mount Sinai Hospital, New York
457:Characterized by Wilms tumor,
1:
3150:Superficial acral fibromyxoma
3057:Juvenile hyaline fibromatosis
2265:10.1158/1078-0432.CCR-17-0710
1975:10.1158/1078-0432.CCR-07-1081
1289:Annals of 3D Printed Medicine
3572:Small-blue-round-cell tumors
3451:Solitary cutaneous leiomyoma
3441:Multiple cutaneous leiomyoma
3162:Ossifying fibromyxoid tumour
2340:Pediatric Blood & Cancer
2086:Journal of Clinical Oncology
2007:Journal of Clinical Oncology
1888:"How is Wilms tumor staged?"
1711:Journal of Clinical Oncology
1556:10.1016/0092-8674(90)90601-A
1461:10.1097/MPH.0b013e3181e5e20d
717:
532:located on the short arm of
528:has been reported. H19 is a
3099:Benign fibrous histiocytoma
2839:Transitional cell carcinoma
2811:Transitional cell carcinoma
2147:. Last Modified: 03/29/2012
613:and is completely excised .
492:Beckwith-Wiedemann Syndrome
423:Associated Genetic Variant
3603:
3379:Embryonal rhabdomyosarcoma
2957:Connective tissue neoplasm
2766:Juxtaglomerular cell tumor
2055:10.1016/j.ejca.2009.01.005
2043:European Journal of Cancer
1502:10.15586/codon.wt.2016.ch1
1302:10.1016/j.stlm.2022.100077
1105:tumor in individuals with
514:(open abdominal wall) and
471:Denys-Drash syndrome (DDS)
155:~90% of children are cured
3503:Malignant rhabdoid tumour
3470:Complex mixed and stromal
3399:
3391:Alveolar rhabdomyosarcoma
2761:Renal medullary carcinoma
2625:National Cancer Institute
2145:National Cancer Institute
2019:10.1200/jco.2001.19.2.488
1390:WhoNamedIt.com: Max Wilms
1219:National Cancer Institute
1020:
961:
885:
834:
773:
672:Inoperable primary tumor.
200:that typically occurs in
59:
50:
3042:Fibroma of tendon sheath
2253:Clinical Cancer Research
2141:Treatment of Wilms Tumor
2099:10.1200/JCO.2005.01.2799
1963:Clinical Cancer Research
1844:Translational Pediatrics
1723:10.1200/JCO.2015.62.1888
1125:computed tomography scan
912:100% (8 people in study)
609:Tumor is limited to the
567:computed tomography scan
429:Description of Syndrome
3072:Oral submucous fibrosis
3014:Aggressive fibromatosis
2930:Not otherwise specified
2844:Squamous-cell carcinoma
2816:Squamous-cell carcinoma
2771:Renal medullary fibroma
1352:10.1038/nrurol.2017.163
708:Treatment and prognosis
246:(in about 20% of cases)
3114:Solitary fibrous tumor
3109:Atypical fibroxanthoma
2313:10.1002/mpo.2950210305
1339:Nature Reviews Urology
675:Lymph node metastasis.
558:
284:
272:
3488:Mixed Müllerian tumor
1969:(22 Pt 1): 6593–602.
753:relapse-free survival
718:staging and treatment
553:
426:Risk for Wilms tumor
278:
270:
3493:Mesoblastic nephroma
3062:Plantar fibromatosis
2992:Desmoplastic fibroma
2725:Mesoblastic nephroma
2697:Renal cell carcinoma
524:An association with
348:rhabdomyosarcomatous
329:metanephric blastema
293:Denys-Drash syndrome
3483:Pleomorphic adenoma
3291:Spindle cell lipoma
3091:histiocytic sarcoma
3067:Pleomorphic fibroma
3029:Collagenous fibroma
3024:Aponeurotic fibroma
2937:Soft-tissue sarcoma
2745:Metanephric adenoma
2398:1990Natur.346..194P
1037:Favorable histology
965:Favorable histology
889:Favorable histology
838:Favorable histology
757:event-free survival
726:virtual karyotyping
616:The surface of the
461:(absence of iris),
250:high blood pressure
240:nausea and vomiting
60:High magnification
3446:Neural fibrolipoma
3421:Angiolipoleiomyoma
3384:Sarcoma botryoides
3281:Pleomorphic lipoma
3250:Myxoid liposarcoma
3214:Clear-cell sarcoma
3047:Fibromatosis colli
2821:Inverted papilloma
2565:External resources
2215:10.1038/ncpuro1218
2172:10.1586/era.09.159
1159:for 1p and 16q LOH
1073:Diffuse anaplastic
993:Diffuse anaplastic
948:Diffuse anaplastic
934:Diffuse anaplastic
869:Diffuse anaplastic
733:random variability
559:
530:long noncoding RNA
285:
273:
244:blood in the urine
220:Signs and symptoms
3567:Pediatric cancers
3554:
3553:
3546:Adenomatoid tumor
3518:Pancreatoblastoma
3464:
3463:
3426:Genital leiomyoma
3286:Lipoblastomatosis
3222:
3221:
3122:
3121:
3077:Pachydermodactyly
2878:
2877:
2793:Ureteral neoplasm
2779:
2778:
2602:
2601:
2352:10.1002/pbc.20891
2259:(13): e115–e122.
1717:(27): 2999–3007.
1669:10.1002/gcc.20553
1496:. pp. 3–21.
1157:Virtual Karyotype
1090:
1089:
551:
522:
521:
397:somatic mutations
377:Mutations of the
179:
178:
30:Medical condition
18:Wilm's tumor
16:(Redirected from
3594:
3375:rhabdomyosarcoma
3364:
3340:
3316:
3311:
3271:Chondroid lipoma
3209:Synovial sarcoma
3145:Cutaneous myxoma
2971:
2962:
2905:
2898:
2891:
2882:
2702:Renal oncocytoma
2687:
2659:
2652:
2645:
2636:
2607:Wilms' tumor
2456:
2444:
2441:
2435:
2432:
2426:
2425:
2406:10.1038/346194a0
2380:
2374:
2373:
2363:
2331:
2325:
2324:
2296:
2287:
2286:
2276:
2244:
2235:
2234:
2198:
2192:
2191:
2154:
2148:
2137:
2112:
2111:
2101:
2073:
2067:
2066:
2037:
2031:
2030:
2001:
1995:
1994:
1957:
1951:
1950:
1948:
1947:
1933:
1927:
1926:
1924:
1923:
1908:
1902:
1901:
1899:
1898:
1884:
1878:
1877:
1867:
1835:
1826:
1825:
1818:
1809:
1808:
1802:
1798:
1796:
1788:
1786:
1785:
1764:
1755:
1751:
1745:
1744:
1734:
1702:
1691:
1690:
1680:
1648:
1642:
1641:
1617:
1611:
1610:
1582:
1576:
1575:
1538:
1532:
1531:
1487:
1481:
1480:
1444:
1438:
1437:
1436:
1435:
1412:
1401:
1398:
1392:
1387:
1381:
1380:
1354:
1329:
1323:
1322:
1304:
1279:
1273:
1269:; accessed from
1260:
1254:
1253:
1251:
1249:
1235:
1229:
1228:
1226:
1225:
1211:
1198:
1197:
1195:
1193:
1177:
1152:Perlman syndrome
1055:Focal anaplastic
979:Focal anaplastic
906:Focal anaplastic
852:Focal anaplastic
764:overall survival
738:
552:
506:(large tongue),
417:
231:loss of appetite
188:, also known as
103:
102:
99:
98:
95:
92:
89:
86:
55:
33:
21:
3602:
3601:
3597:
3596:
3595:
3593:
3592:
3591:
3557:
3556:
3555:
3550:
3527:
3460:
3395:
3362:Skeletal muscle
3360:
3355:
3336:
3331:
3314:
3300:
3218:
3194:
3190:Phyllodes tumor
3172:Fibroepithelial
3166:
3118:
3081:
2996:
2951:
2925:
2909:
2879:
2874:
2858:
2825:
2797:
2775:
2749:
2740:Cystic nephroma
2706:
2676:
2674:genital systems
2663:
2603:
2598:
2597:
2560:
2559:
2467:
2453:
2448:
2447:
2442:
2438:
2433:
2429:
2392:(6280): 194–7.
2382:
2381:
2377:
2333:
2332:
2328:
2298:
2297:
2290:
2246:
2245:
2238:
2200:
2199:
2195:
2166:(12): 1807–15.
2156:
2155:
2151:
2138:
2115:
2092:(29): 7312–21.
2075:
2074:
2070:
2039:
2038:
2034:
2003:
2002:
1998:
1959:
1958:
1954:
1945:
1943:
1935:
1934:
1930:
1921:
1919:
1910:
1909:
1905:
1896:
1894:
1886:
1885:
1881:
1837:
1836:
1829:
1820:
1819:
1812:
1799:
1789:
1783:
1781:
1766:
1765:
1758:
1752:
1748:
1704:
1703:
1694:
1650:
1649:
1645:
1632:(22): 6288–92.
1626:Cancer Research
1619:
1618:
1614:
1584:
1583:
1579:
1540:
1539:
1535:
1512:
1489:
1488:
1484:
1446:
1445:
1441:
1433:
1431:
1414:
1413:
1404:
1399:
1395:
1388:
1384:
1345:(12): 743–752.
1331:
1330:
1326:
1281:
1280:
1276:
1261:
1257:
1247:
1245:
1243:medlineplus.gov
1237:
1236:
1232:
1223:
1221:
1213:
1212:
1201:
1191:
1189:
1179:
1178:
1171:
1166:
1141:Hemihypertrophy
1137:
1115:
1098:
714:5-year survival
710:
701:
693:
666:
639:
603:
591:
544:
542:
508:hemihypertrophy
480:(exon 8 and 9)
463:hemihypertrophy
375:
265:
222:
144:
107:
83:
79:
45:
31:
28:
23:
22:
15:
12:
11:
5:
3600:
3598:
3590:
3589:
3584:
3579:
3574:
3569:
3559:
3558:
3552:
3551:
3549:
3548:
3543:
3537:
3535:
3529:
3528:
3526:
3525:
3523:Carcinosarcoma
3520:
3515:
3513:Hepatoblastoma
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3474:
3472:
3466:
3465:
3462:
3461:
3459:
3458:
3453:
3448:
3443:
3438:
3433:
3431:Leiomyosarcoma
3428:
3423:
3418:
3416:Angioleiomyoma
3413:
3412:
3411:
3400:
3397:
3396:
3394:
3393:
3388:
3387:
3386:
3367:
3365:
3357:
3356:
3354:
3353:
3351:leiomyosarcoma
3343:
3341:
3333:
3332:
3330:
3329:
3319:
3317:
3308:
3302:
3301:
3299:
3298:
3293:
3288:
3283:
3278:
3273:
3267:
3266:
3265:
3264:
3262:Angiomyolipoma
3254:
3253:
3252:
3247:
3232:
3230:
3224:
3223:
3220:
3219:
3217:
3216:
3211:
3205:
3203:
3196:
3195:
3193:
3192:
3187:
3182:
3180:Brenner tumour
3176:
3174:
3168:
3167:
3165:
3164:
3159:
3154:
3153:
3152:
3147:
3132:
3130:
3124:
3123:
3120:
3119:
3117:
3116:
3111:
3106:
3101:
3095:
3093:
3083:
3082:
3080:
3079:
3074:
3069:
3064:
3059:
3054:
3049:
3044:
3039:
3036:
3031:
3026:
3021:
3016:
3010:
3008:
2998:
2997:
2995:
2994:
2989:
2983:
2981:
2968:
2959:
2953:
2952:
2950:
2949:
2944:
2939:
2933:
2931:
2927:
2926:
2910:
2908:
2907:
2900:
2893:
2885:
2876:
2875:
2873:
2872:
2866:
2864:
2860:
2859:
2857:
2856:
2851:
2849:Adenocarcinoma
2846:
2841:
2835:
2833:
2827:
2826:
2824:
2823:
2818:
2813:
2807:
2805:
2799:
2798:
2796:
2795:
2789:
2787:
2781:
2780:
2777:
2776:
2774:
2773:
2768:
2763:
2757:
2755:
2751:
2750:
2748:
2747:
2742:
2737:
2735:Angiomyolipoma
2732:
2727:
2722:
2716:
2714:
2708:
2707:
2705:
2704:
2699:
2693:
2691:
2684:
2678:
2677:
2664:
2662:
2661:
2654:
2647:
2639:
2633:
2632:
2627:
2618:
2613:
2600:
2599:
2596:
2595:
2581:
2569:
2568:
2566:
2562:
2561:
2558:
2557:
2546:
2535:
2524:
2510:
2499:
2484:
2468:
2463:
2462:
2460:
2459:Classification
2452:
2451:External links
2449:
2446:
2445:
2436:
2427:
2375:
2326:
2288:
2236:
2209:(10): 551–60.
2193:
2149:
2113:
2068:
2032:
2013:(2): 488–500.
1996:
1952:
1941:www.cancer.org
1928:
1918:. 25 June 2012
1903:
1892:www.cancer.org
1879:
1827:
1810:
1756:
1746:
1692:
1643:
1612:
1577:
1533:
1510:
1482:
1439:
1402:
1393:
1382:
1333:(2017-12-01).
1324:
1283:(2022-10-01).
1274:
1263:EBSCO database
1255:
1230:
1199:
1181:"Wilms' tumor"
1168:
1167:
1165:
1162:
1161:
1160:
1154:
1149:
1143:
1136:
1133:
1114:
1111:
1097:
1094:
1088:
1087:
1080:
1077:
1074:
1070:
1069:
1062:
1059:
1056:
1052:
1051:
1044:
1041:
1038:
1034:
1033:
1031:
1028:
1025:
1022:
1021:Bilateral (V)
1018:
1017:
1014:
1011:
1008:
1004:
1003:
1000:
997:
994:
990:
989:
986:
983:
980:
976:
975:
972:
969:
966:
963:
959:
958:
955:
952:
949:
945:
944:
941:
938:
935:
931:
930:
927:
924:
921:
917:
916:
913:
910:
907:
903:
902:
896:
893:
890:
887:
883:
882:
876:
873:
870:
866:
865:
859:
856:
853:
849:
848:
845:
842:
839:
836:
832:
831:
821:
818:
815:
808:
807:
798:
795:
792:
788:
787:
784:
781:
778:
775:
771:
770:
767:
760:
749:
747:Histopathology
744:
709:
706:
700:
697:
692:
689:
688:
687:
686:
685:
679:
676:
673:
665:
662:
661:
660:
659:
658:
655:
649:
646:
638:
635:
634:
633:
630:
627:
624:
621:
614:
602:
599:
590:
587:
541:
538:
520:
519:
500:
497:
494:
488:
487:
484:
481:
473:
467:
466:
455:
452:
438:
431:
430:
427:
424:
421:
420:Syndrome Name
374:
371:
370:
369:
361:
325:
324:
319:
313:
264:
261:
260:
259:
253:
247:
241:
238:
235:
234:abdominal pain
232:
229:
221:
218:
190:nephroblastoma
177:
176:
171:
165:
164:
161:
157:
156:
153:
147:
146:
141:
137:
136:
133:
129:
128:
115:
109:
108:
106:
105:
76:
74:
70:
69:
57:
56:
48:
47:
46:Nephroblastoma
42:
38:
37:
29:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3599:
3588:
3585:
3583:
3580:
3578:
3577:Kidney cancer
3575:
3573:
3570:
3568:
3565:
3564:
3562:
3547:
3544:
3542:
3539:
3538:
3536:
3534:
3530:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3475:
3473:
3471:
3467:
3457:
3454:
3452:
3449:
3447:
3444:
3442:
3439:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3419:
3417:
3414:
3410:
3407:
3406:
3405:
3402:
3401:
3398:
3392:
3389:
3385:
3382:
3381:
3380:
3376:
3372:
3369:
3368:
3366:
3363:
3358:
3352:
3348:
3345:
3344:
3342:
3339:
3338:Smooth muscle
3334:
3328:
3324:
3321:
3320:
3318:
3312:
3309:
3307:
3303:
3297:
3294:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3268:
3263:
3260:
3259:
3258:
3255:
3251:
3248:
3246:
3243:
3242:
3241:
3237:
3234:
3233:
3231:
3229:
3225:
3215:
3212:
3210:
3207:
3206:
3204:
3201:
3197:
3191:
3188:
3186:
3183:
3181:
3178:
3177:
3175:
3173:
3169:
3163:
3160:
3158:
3155:
3151:
3148:
3146:
3143:
3142:
3141:
3137:
3134:
3133:
3131:
3129:
3125:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3096:
3094:
3092:
3088:
3084:
3078:
3075:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3011:
3009:
3007:
3003:
2999:
2993:
2990:
2988:
2985:
2984:
2982:
2980:
2976:
2972:
2969:
2967:
2963:
2960:
2958:
2954:
2948:
2945:
2943:
2940:
2938:
2935:
2934:
2932:
2928:
2924:
2920:
2917:
2913:
2906:
2901:
2899:
2894:
2892:
2887:
2886:
2883:
2871:
2868:
2867:
2865:
2861:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2836:
2834:
2832:
2828:
2822:
2819:
2817:
2814:
2812:
2809:
2808:
2806:
2804:
2800:
2794:
2791:
2790:
2788:
2786:
2782:
2772:
2769:
2767:
2764:
2762:
2759:
2758:
2756:
2752:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2717:
2715:
2713:
2709:
2703:
2700:
2698:
2695:
2694:
2692:
2688:
2685:
2683:
2679:
2675:
2671:
2667:
2660:
2655:
2653:
2648:
2646:
2641:
2640:
2637:
2631:
2628:
2626:
2622:
2619:
2617:
2614:
2612:
2608:
2605:
2604:
2594:
2591:
2587:
2586:
2582:
2580:
2576:
2575:
2571:
2570:
2567:
2563:
2556:
2552:
2551:
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2545:
2541:
2540:
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2450:
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2353:
2349:
2345:
2341:
2337:
2330:
2327:
2322:
2318:
2314:
2310:
2307:(3): 172–81.
2306:
2302:
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2293:
2289:
2284:
2280:
2275:
2270:
2266:
2262:
2258:
2254:
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2204:
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2161:
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2100:
2095:
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2079:
2072:
2069:
2064:
2060:
2056:
2052:
2049:(5): 819–26.
2048:
2044:
2036:
2033:
2028:
2024:
2020:
2016:
2012:
2008:
2000:
1997:
1992:
1988:
1984:
1980:
1976:
1972:
1968:
1964:
1956:
1953:
1942:
1938:
1932:
1929:
1917:
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1875:
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1841:
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1832:
1828:
1823:
1817:
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1761:
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1708:
1701:
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1697:
1693:
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1670:
1666:
1663:(6): 461–70.
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1627:
1623:
1616:
1613:
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1600:
1596:
1592:
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1581:
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1569:
1565:
1561:
1557:
1553:
1550:(3): 509–20.
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1521:
1517:
1513:
1511:9780994438119
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1200:
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1155:
1153:
1150:
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1144:
1142:
1139:
1138:
1134:
1132:
1130:
1129:Mario Costici
1126:
1121:
1119:
1118:Sidney Farber
1112:
1110:
1108:
1102:
1095:
1093:
1085:
1081:
1078:
1075:
1072:
1071:
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1060:
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1029:
1026:
1023:
1019:
1015:
1012:
1009:
1006:
1005:
1001:
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987:
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978:
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973:
970:
967:
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960:
956:
953:
950:
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932:
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925:
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911:
908:
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901:
897:
894:
891:
888:
884:
881:
877:
874:
871:
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867:
864:
860:
857:
854:
851:
850:
846:
843:
840:
837:
833:
830:
826:
822:
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816:
814:
810:
809:
806:
802:
799:
796:
793:
790:
789:
785:
782:
779:
776:
772:
768:
765:
761:
758:
754:
750:
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745:
743:
740:
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736:
734:
729:
727:
721:
719:
715:
707:
705:
698:
696:
690:
683:
682:
680:
677:
674:
671:
670:
669:
663:
656:
653:
652:
650:
647:
644:
643:
642:
636:
631:
628:
625:
622:
619:
618:renal capsule
615:
612:
608:
607:
606:
600:
598:
596:
588:
586:
584:
581:or in Europe
580:
576:
572:
568:
563:
556:
539:
537:
535:
534:chromosome 11
531:
527:
517:
516:visceromegaly
513:
509:
505:
501:
498:
495:
493:
490:
489:
485:
482:
479:
478:
474:
472:
469:
468:
464:
460:
456:
453:
451:
450:
445:
444:
439:
436:
435:WAGR syndrome
433:
432:
428:
425:
422:
419:
418:
415:
412:
410:
406:
402:
398:
394:
390:
386:
385:chromosome 11
382:
381:
372:
367:
366:
362:
359:
356:
355:
354:
351:
349:
344:
342:
338:
334:
330:
323:
320:
317:
314:
312:
309:
308:
307:
304:
302:
298:
294:
290:
289:Wilms Tumor 1
282:
281:H&E stain
277:
269:
262:
258:
254:
251:
248:
245:
242:
239:
236:
233:
230:
227:
226:
225:
219:
217:
216:being cured.
213:
211:
207:
203:
199:
195:
191:
187:
183:
175:
172:
170:
166:
162:
158:
154:
152:
148:
142:
138:
135:1–4 years old
134:
130:
127:
123:
119:
116:
114:
110:
101:
78:
77:
75:
73:Pronunciation
71:
67:
66:H&E stain
63:
58:
54:
49:
43:
39:
34:
19:
3582:Rare cancers
3541:Mesothelioma
3498:Wilms' tumor
3497:
3185:Fibroadenoma
3087:Histiocytoma
3006:fibromatosis
2979:fibrosarcoma
2947:Skin sarcoma
2720:Wilms' tumor
2719:
2583:
2572:
2548:
2537:
2526:
2512:
2501:
2486:
2471:
2439:
2430:
2389:
2385:
2378:
2346:(3): 260–7.
2343:
2339:
2329:
2304:
2300:
2256:
2252:
2206:
2202:
2196:
2163:
2159:
2152:
2089:
2085:
2071:
2046:
2042:
2035:
2010:
2006:
1999:
1966:
1962:
1955:
1944:. Retrieved
1940:
1931:
1920:. Retrieved
1915:
1906:
1895:. Retrieved
1891:
1882:
1850:(1): 12–24.
1847:
1843:
1782:. Retrieved
1769:
1749:
1714:
1710:
1660:
1656:
1646:
1629:
1625:
1615:
1593:(4): 260–7.
1590:
1586:
1580:
1547:
1543:
1536:
1492:
1485:
1455:(6): 486–8.
1452:
1448:
1442:
1432:, retrieved
1420:
1396:
1385:
1342:
1338:
1327:
1292:
1288:
1277:
1265:verified by
1258:
1246:. Retrieved
1242:
1233:
1222:. Retrieved
1218:
1190:. Retrieved
1184:
1122:
1116:
1103:
1099:
1096:Epidemiology
1091:
829:radiotherapy
730:
722:
712:The overall
711:
702:
694:
667:
640:
604:
592:
583:chemotherapy
564:
560:
523:
504:macroglossia
475:
447:
441:
413:
409:chromosome 3
405:beta-catenin
378:
376:
363:
357:
352:
345:
326:
305:
286:
263:Pathogenesis
223:
214:
189:
185:
182:Wilms' tumor
181:
180:
145:Radiotherapy
44:Wilms' tumor
36:Wilms' tumor
3533:Mesothelial
3371:Rhabdomyoma
3245:Myelolipoma
3240:liposarcoma
3157:Angiomyxoma
3140:myxosarcoma
2966:Fibromatous
2916:soft tissue
2754:by location
2712:Mixed tumor
2621:Information
2574:MedlinePlus
2076:Grundy PE,
1801:|work=
1186:Mayo Clinic
1123:The use of
801:Nephrectomy
579:nephrectomy
536:(11p15.5).
512:omphalocele
204:(rarely in
186:Wilms tumor
169:Named after
143:Nephrectomy
132:Usual onset
41:Other names
3561:Categories
3478:Adenomyoma
3327:myosarcoma
3228:Lipomatous
3128:Myxomatous
2912:Connective
2539:DiseasesDB
2078:Breslow NE
1946:2015-11-13
1922:2015-11-15
1916:Cancer.Net
1897:2015-11-15
1784:2018-11-12
1434:2018-11-26
1295:: 100077.
1224:2018-11-12
1164:References
813:anaplastic
769:Treatment
620:is intact.
595:anatomical
411:(3p22.1).
365:Anaplastic
322:epithelium
316:mesenchyme
297:metastasis
257:varicocele
255:Rarely as
126:nephrology
62:micrograph
3409:Cutaneous
3404:Leiomyoma
3347:Leiomyoma
3306:Myomatous
3296:Hibernoma
2585:eMedicine
2555:302849000
2550:SNOMED CT
2188:207212698
1803:ignored (
1793:cite book
1477:205860918
1361:1759-4820
1319:251870073
1311:2666-9641
1192:March 10,
880:regimen I
755:(RFS) or
699:Bilateral
664:Stage III
540:Diagnosis
391:from the
389:inherited
358:Favorable
337:cartilage
210:Max Wilms
174:Max Wilms
160:Frequency
151:Prognosis
140:Treatment
113:Specialty
3200:Synovial
2923:sarcomas
2854:Melanoma
2593:ped/2440
2590:med/3093
2370:16700047
2283:28674120
2231:23599363
2223:18836464
2180:19954292
2108:16129848
2063:19231157
2027:11208843
1991:17036977
1983:18006759
1874:26835318
1779:26389282
1741:26304882
1687:18311776
1638:11103785
1572:29092372
1528:78834136
1520:27512769
1469:20562648
1429:26389282
1369:29089605
1135:See also
1107:aniridia
811:Diffuse
691:Stage IV
637:Stage II
571:MRI scan
459:aniridia
393:germline
350:Wilms).
318:(stroma)
311:blastema
301:bleeding
202:children
118:Oncology
3315:General
3002:Fibroma
2975:Fibroma
2831:Urethra
2803:Bladder
2670:urinary
2668:of the
2533:D009396
2508:M8960/3
2422:4350729
2414:2164159
2394:Bibcode
2361:1543666
2321:7680412
2274:5538793
1865:4728859
1732:4567702
1678:4332772
1607:9781905
1564:2154335
1377:9418050
1248:11 June
1113:History
1027:61% EFS
1024:Overall
1010:31% EFS
996:33% EFS
982:61% EFS
968:76% RFS
951:65% EFS
937:46% EFS
923:71% RFS
909:88% RFS
892:87% RFS
872:83% EFS
855:80% EFS
841:86% RFS
817:68% EFS
794:94% RFS
762:4 Year
751:4 Year
601:Stage I
589:Staging
555:CT scan
454:45–60%
198:kidneys
196:of the
192:, is a
122:urology
3257:PEComa
3236:Lipoma
3136:Myxoma
2919:tumors
2785:Ureter
2682:Kidney
2666:Tumors
2611:Curlie
2579:001575
2522:607102
2519:194070
2420:
2412:
2386:Nature
2368:
2358:
2319:
2281:
2271:
2229:
2221:
2186:
2178:
2106:
2061:
2025:
1989:
1981:
1872:
1862:
1777:
1739:
1729:
1685:
1675:
1636:
1605:
1570:
1562:
1526:
1518:
1508:
1475:
1467:
1427:
1375:
1367:
1359:
1317:
1309:
1148:(NWTS)
611:kidney
575:biopsy
401:CTNNB1
333:muscle
206:adults
194:cancer
104:
3456:STUMP
3323:Myoma
3202:-like
2863:Other
2623:from
2503:ICD-O
2497:189.0
2418:S2CID
2227:S2CID
2184:S2CID
1987:S2CID
1568:S2CID
1524:S2CID
1473:S2CID
1373:S2CID
1315:S2CID
1084:DD-4A
1066:DD-4A
1048:DD-4A
900:DD-4A
863:DD-4A
825:EE-4A
805:EE-4A
759:(EFS)
742:Stage
237:fever
2921:and
2672:and
2544:8896
2528:MeSH
2514:OMIM
2492:9-CM
2410:PMID
2366:PMID
2317:PMID
2279:PMID
2219:PMID
2176:PMID
2104:PMID
2059:PMID
2023:PMID
1979:PMID
1870:PMID
1805:help
1775:PMID
1737:PMID
1683:PMID
1634:PMID
1603:PMID
1560:PMID
1544:Cell
1516:PMID
1506:ISBN
1465:PMID
1425:PMID
1365:PMID
1357:ISSN
1307:ISSN
1267:URAC
1250:2022
1194:2022
886:III
827:and
766:(OS)
483:74%
449:PAX6
446:and
341:bone
2609:at
2488:ICD
2482:C64
2473:ICD
2402:doi
2390:346
2356:PMC
2348:doi
2309:doi
2269:PMC
2261:doi
2211:doi
2168:doi
2143:at
2094:doi
2051:doi
2015:doi
1971:doi
1860:PMC
1852:doi
1727:PMC
1719:doi
1673:PMC
1665:doi
1595:doi
1552:doi
1498:doi
1457:doi
1347:doi
1297:doi
1079:42%
1076:25%
1061:88%
1058:76%
1043:87%
1040:65%
1030:80%
1013:44%
999:33%
985:72%
971:86%
962:IV
954:67%
940:53%
926:71%
895:94%
875:82%
858:80%
844:98%
835:II
820:80%
797:98%
783:98%
780:85%
569:or
526:H19
499:7%
477:WT1
443:WT1
380:WT1
184:or
3563::
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2588::
2577::
2553::
2542::
2531::
2517::
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2088:.
2084:.
2057:.
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2045:.
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2011:19
2009:.
1985:.
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1967:13
1965:.
1939:.
1914:.
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