1667:, or adhesive area, processes that are reliant on cytoskeletal integrity. These mechanically induced localization phenomena are thought to be the result of nuclear flattening induced pore size change, mechanosensitive nuclear membrane ion channels, mechanical protein stability, or a variety of other factors. These mechanical factors have also been linked to certain cancer cells via nuclear softening and higher ECM stiffnesses. Under this framework, the nuclear softening phenotype of cancer cells would promote nuclear flattening in response to a force, causing YAP localization, which could explain its over-expression and promoted proliferation in oncogenic cells. Additionally, the higher ECM stiffness phenotype commonly seen in tumors due to enhanced integrin signaling could flatten the cell and nucleus, once again causing higher YAP nuclear localization. Likewise, the opposite effect of nuclear stiffening as a result of a variety of stimuli such as an over-expression of
1623:
350:
327:
224:
249:
1434:
4556:
4571:
4586:
356:
255:
4601:
29:
1603:
As YAP and TAZ are transcriptional co-activators, they do not have DNA-binding domains. Instead, when inside the nucleus, they regulate gene expression through TEAD1-4 which are sequence-specific transcription factors that mediate the main transcriptional output of the Hippo pathway. The YAP/TAZ and
1696:
The YAP1 oncogene serves as a target for the development of new cancer drugs. Small compounds have been identified that disrupt the YAP1-TEAD complex or block the binding function of WW domains. These small molecules represent lead compounds for the development of therapies for cancer patients, who
55:
1684:
Dysregulation of YAP/TAZ-mediated transcriptional activity is implicated in the development of abnormal cell growth and hyperactivation of YAP and TAZ has been observed amongst many cancers. Hence YAP1 represents a potential target for the treatment of cancer.
1608:
interaction which functions as a transcriptional repressor. Mouse models with YAP over-expression have been shown to exhibit up-regulation of the TEAD target gene expression which results in increased expansion of progenitor cells and tissue overgrowth.
3945:
Shimomura T, Miyamura N, Hata S, Miura R, Hirayama J, Nishina H (January 2014). "The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity".
1655:. LATS1/2 then phosphorylate YAP and TAZ which causes them to bind with 14-3-3, resulting in cytoplasmic sequestration of YAP and TAZ. The result of the activation of this pathway is the restriction of YAP/TAZ from entering the cell nucleus.
1469:
interacting domain). Next, following a single WW domain, which is present in the YAP1-1 isoform, and two WW domains, which are present in the YAP1-2 isoform, there is the SH3-BM (Src
Homology 3 binding motif). Following the SH3-BM is a TAD
1630:
At the biochemical level, YAP is part of and regulated by the Hippo signaling pathway where a kinase cascade results in its βinactivationβ, along with that of TAZ. In this signaling cascade, TAO kinases phosphorylate Ste20-like kinases,
2693:
Omerovic J, Puggioni EM, Napoletano S, Visco V, Fraioli R, Frati L, et al. (April 2004). "Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level".
1626:
On the left, the signaling cascade is inactivated so YAP readily localizes to the nucleus for transcription. On the right, the signal cascade causes YAP to localize to the cytoplasm, preventing transcription.
2045:
AndrΓ© B, Springael JY (December 1994). "WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65".
1729:
gene have been identified in two families with major eye malformations with or without extra-ocular features such as hearing loss, cleft lip, intellectual disability and renal disease.
2654:"WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus"
4641:
363:
262:
4030:
Gjorevski N, Sachs N, Manfrin A, Giger S, Bragina ME, OrdΓ³Γ±ez-MorΓ‘n P, et al. (November 2016). "Designer matrices for intestinal stem cell and organoid culture".
3495:"Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation"
4555:
1875:
Sudol M (August 1994). "Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product".
1410:
1035:
1016:
185:
4570:
2324:"Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)"
1651:
which are scaffold proteins that assist in the recruitment and phosphorylation of LATS1/2. LATS1/2 can also be phosphorylated by two groups of
4801:
4634:
4535:
1854:
1836:
4585:
1904:"The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP"
2482:"Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein"
1600:
YAP/TAZ have also been shown to act as stiffness sensors, regulating mechanotransduction independently of the Hippo signalling cascade.
1307:
349:
4680:
2139:"Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain"
326:
4600:
1314:
4627:
2232:"TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm"
2279:
Ren R, Mayer BJ, Cicchetti P, Baltimore D (February 1993). "Identification of a ten-amino acid proline-rich SH3 binding site".
1823:
1802:
4806:
2523:"Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling"
2180:"Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene"
1710:
248:
223:
3054:"Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling"
1819:
4365:"Non-destructive inhibition of metallofullerenol Gd@C(82)(OH)(22) on WW domain: implication on signal transduction pathway"
1453:
of the YAP1 gene product were initially identified, named YAP1-1 and YAP1-2, which differed by the presence of an extra 38
52:
1798:
2381:"Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50"
1688:
While YAP has been identified as a proto-oncogene, it can also act as a tumor suppressor depending on cellular context.
165:
3707:"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control"
1714:
1622:
362:
261:
4528:
4471:"Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects"
4422:"Hippo/YAP signaling pathway mitigates bloodβbrain barrier disruption after cerebral ischemia/reperfusion injury"
3843:"Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence"
1546:), are the main effectors of the Hippo tumor suppressor pathway. When the pathway is activated, YAP1 and TAZ are
1382:
355:
254:
3798:
Cross SE, Jin YS, Rao J, Gimzewski JK (December 2007). "Nanomechanical analysis of cells from cancer patients".
3258:"The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression"
1080:
173:
156:, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap, Yes1 associated transcriptional regulator, YAP-1
4662:
4654:
1394:
1061:
1471:
1386:
4316:"Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP"
3454:"The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway"
1491:
237:
1663:
Additionally, YAP is regulated by mechanical cues such as extracellular matrix (ECM) rigidity, strain,
1433:
3757:
Elosegui-Artola A, Andreu I, Beedle AE, Lezamiz A, Uroz M, Kosmalska AJ, et al. (November 2017).
3405:"Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway"
3307:"Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP"
2564:"Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-Ξ² Pathways"
4751:
4521:
4376:
3854:
3807:
3612:
3555:
2335:
2288:
2093:
1964:
1466:
152:
4118:"The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment"
1639:, at their activation loops (Thr183 for MST1 and Thr180 for MST2). Active MST1/2 then phosphorylate
4650:
4469:
Williamson KA, Rainger J, Floyd JA, Ansari M, Meynert A, Aldridge KV, et al. (February 2014).
3658:"Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade"
1286:
1261:
1257:
1253:
1243:
1239:
1235:
1231:
1227:
1203:
1178:
1174:
1170:
1160:
1156:
1152:
1148:
1144:
4098:
4055:
3599:
Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, et al. (October 2015).
3524:
3189:
2361:
2119:
1933:
197:
4267:"Structures of YAP protein domains reveal promising targets for development of new cancer drugs"
1290:
1265:
1207:
1182:
1457:
that encoded the WW domain. Apart from the WW domain, the modular structure of YAP1 contains a
4500:
4451:
4402:
4345:
4296:
4247:
4196:
4147:
4090:
4047:
4012:
3963:
3924:
3880:
3823:
3780:
3736:
3687:
3638:
3581:
3516:
3475:
3434:
3385:
3336:
3287:
3238:
3181:
3137:
3083:
3052:
Oka T, Remue E, Meerschaert K, Vanloo B, Boucherie C, Gfeller D, et al. (December 2010).
3034:
2993:
2944:
2893:
2842:
2793:
2752:
2711:
2675:
2634:
2593:
2544:
2503:
2462:
2410:
2353:
2304:
2261:
2209:
2160:
2111:
2062:
2027:
1992:
1925:
1884:
1760:
1739:
145:
45:
4619:
2433:"A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator"
4688:
4490:
4482:
4441:
4433:
4392:
4384:
4335:
4327:
4286:
4278:
4237:
4227:
4186:
4178:
4137:
4129:
4082:
4039:
4002:
3994:
3981:
Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PC, Pinter J, et al. (August 2013).
3955:
3914:
3870:
3862:
3815:
3770:
3726:
3718:
3677:
3669:
3628:
3620:
3571:
3563:
3506:
3465:
3424:
3416:
3375:
3367:
3326:
3318:
3277:
3269:
3228:
3220:
3171:
3127:
3119:
3073:
3065:
3024:
2983:
2975:
2934:
2924:
2883:
2873:
2832:
2824:
2783:
2742:
2731:"Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains"
2703:
2665:
2624:
2583:
2575:
2534:
2521:
Ferrigno O, Lallemand F, Verrecchia F, L'Hoste S, Camonis J, Atfi A, Mauviel A (July 2002).
2493:
2452:
2444:
2400:
2392:
2343:
2296:
2251:
2243:
2199:
2191:
2150:
2101:
2054:
2019:
1982:
1972:
1915:
1414:
442:
373:
317:
272:
3983:"Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation"
3013:"Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP"
3841:
Guck J, Schinkinger S, Lincoln B, Wottawah F, Ebert S, Romeyke M, et al. (May 2005).
2772:"Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)"
1706:
1563:
417:
193:
3601:"MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway"
4380:
4314:
Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee SJ, Anders RA, et al. (June 2012).
3858:
3811:
3616:
3559:
2613:"Physical interaction with Yes-associated protein enhances p73 transcriptional activity"
2611:
Strano S, Munarriz E, Rossi M, Castagnoli L, Shaul Y, Sacchi A, et al. (May 2001).
2339:
2292:
2178:
Gaffney CJ, Oka T, Mazack V, Hilman D, Gat U, Muramatsu T, et al. (November 2012).
2097:
1968:
4495:
4470:
4446:
4421:
4397:
4364:
4340:
4315:
4291:
4266:
4242:
4215:
4191:
4166:
4142:
4117:
4007:
3982:
3875:
3842:
3731:
3706:
3682:
3657:
3633:
3600:
3576:
3543:
3429:
3404:
3380:
3355:
3331:
3306:
3282:
3257:
3233:
3208:
3157:"Using biomaterials to study stem cell mechanotransduction, growth and differentiation"
3132:
3107:
2988:
2963:
2939:
2912:
2888:
2861:
2837:
2812:
2588:
2563:
2457:
2432:
2405:
2380:
2204:
2179:
1987:
1953:"Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon"
1952:
1559:
1547:
1499:
1462:
1442:
2348:
2323:
2256:
2231:
1951:
Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, et al. (August 2006).
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
714:
709:
704:
699:
694:
689:
673:
668:
663:
658:
653:
648:
643:
638:
633:
28:
4795:
3511:
3494:
2106:
2081:
2023:
1769:
1748:
1398:
620:
3256:
Koontz LM, Liu-Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, et al. (May 2013).
3193:
2365:
2137:
Sudol M, Bork P, Einbond A, Kastury K, Druck T, Negrini M, et al. (June 1995).
2123:
2010:
Bork P, Sudol M (December 1994). "The WW domain: a signalling site in dystrophin?".
1937:
4102:
4059:
3528:
1664:
1582:
1562:. When the Hippo pathway is not activated, YAP1/TAZ enter the nucleus and regulate
435:
214:
177:
4073:
Harvey KF, Zhang X, Thomas DM (April 2013). "The Hippo pathway and human cancer".
2811:
Liu X, Yang N, Figel SA, Wilson KE, Morrison CD, Gelman IH, Zhang J (March 2013).
2498:
2481:
4282:
3673:
3470:
3453:
3420:
3273:
3123:
2562:
AragΓ³n E, Goerner N, Xi Q, Gomes T, Gao S, MassaguΓ© J, Macias MJ (October 2012).
2379:
Mohler PJ, Kreda SM, Boucher RC, Sudol M, Stutts MJ, Milgram SL (November 1999).
201:
3866:
2707:
1859:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1841:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1454:
4486:
3959:
3919:
3902:
3775:
3759:"Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores"
3758:
2195:
1957:
Proceedings of the
National Academy of Sciences of the United States of America
1920:
1903:
518:
4437:
3567:
3544:"MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation"
3053:
2813:"PTPN14 interacts with and negatively regulates the oncogenic function of YAP"
2579:
2448:
1475:
1402:
334:
231:
181:
3156:
2964:"Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein"
2155:
2138:
1498:. Several other functional partners of YAP1 were identified, including RUNX,
4420:
Gong P, Zhang Z, Zou C, Tian Q, Chen X, Hong M, et al. (January 2019).
4232:
3998:
2929:
2878:
2300:
1977:
1555:
1495:
1487:
1446:
1390:
980:
578:
456:
401:
388:
300:
287:
189:
4504:
4455:
4406:
4349:
4331:
4300:
4251:
4200:
4151:
4094:
4051:
4016:
3967:
3928:
3884:
3827:
3819:
3784:
3740:
3691:
3642:
3585:
3520:
3479:
3438:
3389:
3371:
3340:
3322:
3291:
3242:
3185:
3141:
3087:
3078:
3038:
2997:
2948:
2897:
2846:
2797:
2788:
2771:
2756:
2747:
2730:
2715:
2679:
2670:
2653:
2638:
2629:
2612:
2597:
2548:
2539:
2522:
2507:
2466:
2414:
2265:
2213:
2058:
1996:
1929:
1401:. YAP1 was first identified by virtue of its ability to associate with the
3705:
Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, et al. (November 2007).
2396:
2357:
2308:
2164:
2115:
2066:
2031:
1888:
1604:
TEAD interaction competitively inhibits and actively dissociates the TEAD/
1354:
1349:
4764:
3305:
Chen Q, Zhang N, Xie R, Wang W, Cai J, Choi KS, et al. (June 2015).
3029:
3012:
2828:
1450:
1422:
1338:
1125:
1106:
4043:
3722:
3224:
2979:
901:
regulation of metanephric nephron tubule epithelial cell differentiation
791:
positive regulation of intracellular estrogen receptor signaling pathway
4708:
4703:
3624:
3069:
2247:
1774:
1764:
1753:
1743:
1668:
1539:
1511:
1458:
1092:
1047:
4388:
3903:"Cancer invasion and the microenvironment: plasticity and reciprocity"
3176:
2862:"Angiomotin-like proteins associate with and negatively regulate YAP1"
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
4780:
4718:
2911:
Chan SW, Lim CJ, Chong YF, Pobbati AV, Huang C, Hong W (March 2011).
1594:
1551:
1523:
1441:
Cloning of the YAP1 gene facilitated the identification of a modular
1322:
1002:
649:
RNA polymerase II cis-regulatory region sequence-specific DNA binding
4182:
4133:
4086:
2962:
Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan KL (January 2011).
2913:"Hippo pathway-independent restriction of TAZ and YAP by angiomotin"
1569:
It is reported that several genes are regulated by YAP1, including
4736:
4731:
4693:
4564:: YAP65 (L30K mutant) WW domain in Complex with GTPPPPYTVG peptide
1652:
1648:
1644:
1621:
1605:
1590:
1586:
1574:
1570:
1543:
1519:
1515:
1507:
1432:
3656:
Zheng Y, Wang W, Liu B, Deng H, Uster E, Pan D (September 2015).
2230:
Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML (May 2001).
1486:
YAP1 is a transcriptional co-activator and its proliferative and
965:
961:
4741:
4726:
4698:
4670:
1640:
1636:
1632:
1578:
1535:
1531:
1527:
1406:
169:
4623:
4517:
3209:"TEAD mediates YAP-dependent gene induction and growth control"
3207:
Zhao B, Ye X, Yu J, Li L, Li W, Li S, et al. (July 2008).
1494:, which up-regulate genes that promote cell growth and inhibit
4513:
1503:
1490:
activity is driven by its association with the TEAD family of
4579:: YAP65 WW domain S24-Amino-Ethylsulfanyl-Acetic Acid mutant
2431:
Yagi R, Chen LF, Shigesada K, Murakami Y, Ito Y (May 1999).
2082:"The rsp5-domain is shared by proteins of diverse functions"
1759:
Overview of all the structural information available in the
1738:
Overview of all the structural information available in the
921:
negative regulation of extrinsic apoptotic signaling pathway
1902:
Huang J, Wu S, Barrera J, Matthews K, Pan D (August 2005).
771:
negative regulation of nucleic acid-templated transcription
2322:
Wang S, Raab RW, Schatz PJ, Guggino WB, Li M (May 1998).
856:
positive regulation of transcription by RNA polymerase II
941:
positive regulation of cardiac muscle cell proliferation
756:
transcription initiation from RNA polymerase II promoter
425:
3164:
Journal of Tissue
Engineering and Regenerative Medicine
3108:"The hippo signaling pathway in development and cancer"
1671:, has been shown to decrease nuclear YAP localization.
911:
positive regulation of stem cell population maintenance
3403:
Boggiano JC, Vanderzalm PJ, Fehon RG (November 2011).
2480:
Zhao B, Kim J, Ye X, Lai ZC, Guan KL (February 2009).
906:
positive regulation of canonical Wnt signaling pathway
831:
negative regulation of epithelial cell differentiation
3452:
Poon CL, Lin JI, Zhang X, Harvey KF (November 2011).
781:
regulation of hematopoietic stem cell differentiation
590:
4594:: YAP65 WW domain complexed to N-(n-octyl)-GPPPY-NH2
4216:"Dual role of YAP: oncoprotein and tumor suppressor"
2652:
Komuro A, Nagai M, Navin NE, Sudol M (August 2003).
816:
positive regulation of cell population proliferation
4773:
4750:
4717:
4679:
4661:
3948:
2047:
1279:
1226:
1196:
1143:
776:
positive regulation of transcription, DNA-templated
3493:Callus BA, Verhagen AM, Vaux DL (September 2006).
1815:
1813:
1811:
1794:
1792:
1790:
1385:that promotes transcription of genes involved in
372:
271:
4265:Sudol M, Shields DC, Farooq A (September 2012).
4165:Moroishi T, Hansen CG, Guan KL (February 2015).
3155:McMurray RJ, Dalby MJ, Tsimbouri PM (May 2015).
1773:(Mouse Transcriptional coactivator YAP1) at the
1752:(Human Transcriptional coactivator YAP1) at the
1697:harbor amplified or overexpressed YAP oncogene.
916:negative regulation of stem cell differentiation
1725:Heterozygous loss-of-function mutations in the
1425:, which is amplified in various human cancers.
16:Protein-coding gene in the species Homo sapiens
1820:GRCm38: Ensembl release 89: ENSMUSG00000053110
1397:which regulates organ size, regeneration, and
4635:
4529:
4167:"The emerging roles of YAP and TAZ in cancer"
886:regulation of canonical Wnt signaling pathway
8:
4271:Seminars in Cell & Developmental Biology
3354:Meng Z, Moroishi T, Guan KL (January 2016).
4609:: YAP65 WW domain complexed to Acetyl-PLPPY
3011:Oka T, Schmitt AP, Sudol M (January 2012).
1799:GRCh38: Ensembl release 89: ENSG00000137693
851:regulation of cell population proliferation
4642:
4628:
4620:
4536:
4522:
4514:
3542:Praskova M, Xia F, Avruch J (March 2008).
1705:The Hippo/YAP signaling pathway may exert
1223:
1140:
976:
731:regulation of transcription, DNA-templated
616:
413:
312:
209:
63:
4494:
4445:
4396:
4339:
4290:
4241:
4231:
4190:
4141:
4006:
3918:
3874:
3774:
3730:
3681:
3632:
3575:
3510:
3469:
3428:
3379:
3330:
3281:
3232:
3175:
3131:
3077:
3028:
2987:
2938:
2928:
2887:
2877:
2860:Wang W, Huang J, Chen J (February 2011).
2836:
2787:
2770:Oka T, Mazack V, Sudol M (October 2008).
2746:
2669:
2628:
2587:
2538:
2497:
2456:
2404:
2347:
2255:
2203:
2154:
2105:
1986:
1976:
1919:
876:bud elongation involved in lung branching
3356:"Mechanisms of Hippo pathway regulation"
841:somatic stem cell population maintenance
821:regulation of keratinocyte proliferation
746:cellular response to DNA damage stimulus
4551:
3901:Friedl P, Alexander S (November 2011).
1786:
796:progesterone receptor signaling pathway
3101:
3099:
3097:
2426:
2424:
18:
3940:
3938:
3896:
3894:
3752:
3750:
2225:
2223:
896:regulation of stem cell proliferation
377:
338:
333:
276:
235:
230:
7:
4116:Johnson R, Halder G (January 2014).
2080:Hofmann K, Bucher P (January 1995).
1870:
1868:
1478:-binding motif (PDZ-BM) (Figure 1).
881:lung epithelial cell differentiation
751:cellular response to gamma radiation
549:vestibular membrane of cochlear duct
2917:The Journal of Biological Chemistry
2866:The Journal of Biological Chemistry
2776:The Journal of Biological Chemistry
2735:The Journal of Biological Chemistry
2658:The Journal of Biological Chemistry
2617:The Journal of Biological Chemistry
2143:The Journal of Biological Chemistry
1577:, connective tissue growth factor (
1465:, which is followed by a TID (TEAD
926:protein-containing complex assembly
861:positive regulation of organ growth
644:protein heterodimerization activity
4475:American Journal of Human Genetics
1437:Modular Structure of YAP1 Isoforms
1393:genes. YAP1 is a component in the
1276:
1193:
1116:
1097:
1071:
1052:
1026:
1007:
946:cardiac muscle tissue regeneration
891:cellular response to retinoic acid
811:embryonic heart tube morphogenesis
659:transcription coactivator activity
634:transcription corepressor activity
595:
513:
451:
430:
14:
4363:Kang SG, Huynh T, Zhou R (2012).
2729:Espanel X, Sudol M (April 2001).
4599:
4584:
4569:
4554:
3512:10.1111/j.1742-4658.2006.05427.x
361:
354:
348:
325:
260:
253:
247:
222:
27:
1554:residue and sequestered in the
705:transcription regulator complex
4122:Nature Reviews. Drug Discovery
2012:Trends in Biochemical Sciences
1711:blood-brain barrier disruption
1381:, is a protein that acts as a
579:More reference expression data
1:
2499:10.1158/0008-5472.CAN-08-2997
2349:10.1016/S0014-5793(98)00402-5
951:regulation of gene expression
866:paraxial mesoderm development
761:cell population proliferation
346:
245:
4802:Genes on human chromosome 11
4283:10.1016/j.semcdb.2012.05.002
3674:10.1016/j.devcel.2015.08.014
3471:10.1016/j.devcel.2011.09.012
3421:10.1016/j.devcel.2011.08.028
3274:10.1016/j.devcel.2013.04.021
3124:10.1016/j.devcel.2010.09.011
2107:10.1016/0014-5793(94)01415-W
2024:10.1016/0968-0004(94)90053-1
871:lateral mesoderm development
826:keratinocyte differentiation
741:transcription, DNA-templated
674:transcription factor binding
4220:Journal of Thoracic Disease
3867:10.1529/biophysj.104.045476
2708:10.1016/j.yexcr.2003.12.002
2385:The Journal of Cell Biology
1715:ischemia/reperfusion injury
1709:effects through mitigating
669:proline-rich region binding
495:superficial temporal artery
4823:
4487:10.1016/j.ajhg.2014.01.001
4426:Behavioural Brain Research
3960:10.1016/j.bbrc.2013.12.100
3920:10.1016/j.cell.2011.11.016
3776:10.1016/j.cell.2017.10.008
2696:Experimental Cell Research
2196:10.1016/j.gene.2012.08.025
1921:10.1016/j.cell.2005.06.007
1308:Chr 11: 102.11 β 102.23 Mb
766:regulation of neurogenesis
664:protein C-terminus binding
561:retinal pigment epithelium
4549:
4438:10.1016/j.bbr.2018.08.003
4226:(Suppl 33): S3895βS3898.
3568:10.1016/j.cub.2008.02.006
2580:10.1016/j.str.2012.07.014
1855:"Mouse PubMed Reference:"
1837:"Human PubMed Reference:"
1461:-rich region at the very
1383:transcription coregulator
1353:
1348:
1344:
1337:
1321:
1302:
1283:
1250:
1219:
1200:
1167:
1136:
1123:
1119:
1104:
1100:
1091:
1078:
1074:
1059:
1055:
1046:
1033:
1029:
1014:
1010:
1001:
986:
979:
975:
959:
619:
615:
603:
598:
589:
576:
525:
516:
463:
454:
424:
416:
412:
395:
382:
345:
324:
315:
311:
294:
281:
244:
221:
212:
208:
163:
160:
150:
143:
138:
71:
66:
49:
44:
39:
35:
26:
21:
3060:(Submitted manuscript).
2156:10.1074/jbc.270.24.14733
1371:yes-associated protein 1
786:response to progesterone
4655:Hippo signaling pathway
4320:Genes & Development
4233:10.21037/jtd.2018.10.70
4214:Jho E (November 2018).
3999:10.1126/science.1240104
3711:Genes & Development
3360:Genes & Development
3311:Genes & Development
3213:Genes & Development
3058:The Biochemical Journal
2968:Genes & Development
2930:10.1074/jbc.C110.212621
2879:10.1074/jbc.C110.205401
2449:10.1093/emboj/18.9.2551
2301:10.1126/science.8438166
2236:Genes & Development
1978:10.1073/pnas.0605579103
1395:hippo signaling pathway
553:external carotid artery
541:internal carotid artery
4332:10.1101/gad.192856.112
4171:Nature Reviews. Cancer
4075:Nature Reviews. Cancer
3820:10.1038/nnano.2007.388
3372:10.1101/gad.274027.115
3323:10.1101/gad.264234.115
3106:Pan D (October 2010).
2789:10.1074/jbc.M804380200
2748:10.1074/jbc.M008568200
2671:10.1074/jbc.M305597200
2630:10.1074/jbc.M010484200
2540:10.1038/sj.onc.1205623
2059:10.1006/bbrc.1994.2793
1627:
1472:transactivation domain
1438:
1387:cellular proliferation
4807:Transcription factors
3800:Nature Nanotechnology
3605:Nature Communications
2397:10.1083/jcb.147.4.879
1675:Clinical significance
1625:
1538:. YAP1 and its close
1492:transcription factors
1436:
836:notochord development
238:Chromosome 11 (human)
4752:Transcription factor
3769:(6): 1397β1410.e14.
3030:10.1038/onc.2011.216
2829:10.1038/onc.2012.147
1467:transcription factor
340:Chromosome 9 (mouse)
67:List of PDB id codes
40:Available structures
4381:2012NatSR...2E.957K
4044:10.1038/nature20168
3859:2005BpJ....88.3689G
3847:Biophysical Journal
3812:2007NatNa...2..780C
3723:10.1101/gad.1602907
3617:2015NatCo...6.8357M
3560:2008CBio...18..311P
3225:10.1101/gad.1664408
2980:10.1101/gad.2000111
2340:1998FEBSL.427..103W
2293:1993Sci...259.1157R
2098:1995FEBSL.358..153H
1969:2006PNAS..10312405O
1659:Mechanotransductive
471:germinal epithelium
4369:Scientific Reports
3662:Developmental Cell
3625:10.1038/ncomms9357
3458:Developmental Cell
3409:Developmental Cell
3262:Developmental Cell
3112:Developmental Cell
3070:10.1042/BJ20100870
2248:10.1101/gad.888601
1628:
1439:
1315:Chr 9: 7.93 β 8 Mb
1081:ENSMUSG00000053110
931:tissue homeostasis
801:cell morphogenesis
736:contact inhibition
724:Biological process
683:Cellular component
627:Molecular function
475:tail of epididymis
4789:
4788:
4651:Signaling pathway
4617:
4616:
4389:10.1038/srep00957
4038:(7630): 560β564.
3993:(6149): 1240104.
3177:10.1002/term.1957
2287:(5098): 1157β61.
1373:), also known as
1364:
1363:
1360:
1359:
1333:
1332:
1298:
1297:
1273:
1272:
1215:
1214:
1190:
1189:
1132:
1131:
1113:
1112:
1087:
1086:
1068:
1067:
1042:
1041:
1023:
1022:
971:
970:
654:chromatin binding
611:
610:
607:
606:
585:
584:
572:
571:
510:
509:
503:corpus epididymis
408:
407:
307:
306:
134:
133:
130:
129:
50:Ortholog search:
4814:
4644:
4637:
4630:
4621:
4603:
4588:
4573:
4558:
4538:
4531:
4524:
4515:
4509:
4508:
4498:
4466:
4460:
4459:
4449:
4417:
4411:
4410:
4400:
4360:
4354:
4353:
4343:
4311:
4305:
4304:
4294:
4262:
4256:
4255:
4245:
4235:
4211:
4205:
4204:
4194:
4162:
4156:
4155:
4145:
4113:
4107:
4106:
4070:
4064:
4063:
4027:
4021:
4020:
4010:
3978:
3972:
3971:
3942:
3933:
3932:
3922:
3898:
3889:
3888:
3878:
3838:
3832:
3831:
3795:
3789:
3788:
3778:
3754:
3745:
3744:
3734:
3702:
3696:
3695:
3685:
3653:
3647:
3646:
3636:
3596:
3590:
3589:
3579:
3539:
3533:
3532:
3514:
3499:The FEBS Journal
3490:
3484:
3483:
3473:
3449:
3443:
3442:
3432:
3400:
3394:
3393:
3383:
3351:
3345:
3344:
3334:
3302:
3296:
3295:
3285:
3253:
3247:
3246:
3236:
3204:
3198:
3197:
3179:
3161:
3152:
3146:
3145:
3135:
3103:
3092:
3091:
3081:
3049:
3043:
3042:
3032:
3008:
3002:
3001:
2991:
2959:
2953:
2952:
2942:
2932:
2908:
2902:
2901:
2891:
2881:
2857:
2851:
2850:
2840:
2808:
2802:
2801:
2791:
2782:(41): 27534β46.
2767:
2761:
2760:
2750:
2741:(17): 14514β23.
2726:
2720:
2719:
2690:
2684:
2683:
2673:
2664:(35): 33334β41.
2649:
2643:
2642:
2632:
2623:(18): 15164β73.
2608:
2602:
2601:
2591:
2559:
2553:
2552:
2542:
2518:
2512:
2511:
2501:
2477:
2471:
2470:
2460:
2437:The EMBO Journal
2428:
2419:
2418:
2408:
2376:
2370:
2369:
2351:
2319:
2313:
2312:
2276:
2270:
2269:
2259:
2227:
2218:
2217:
2207:
2175:
2169:
2168:
2158:
2149:(24): 14733β41.
2134:
2128:
2127:
2109:
2077:
2071:
2070:
2042:
2036:
2035:
2007:
2001:
2000:
1990:
1980:
1963:(33): 12405β10.
1948:
1942:
1941:
1923:
1899:
1893:
1892:
1872:
1863:
1862:
1851:
1845:
1844:
1833:
1827:
1817:
1806:
1796:
1692:As a drug target
1415:tyrosine kinases
1389:and suppressing
1346:
1345:
1317:
1310:
1293:
1277:
1268:
1224:
1220:RefSeq (protein)
1210:
1194:
1185:
1141:
1117:
1098:
1072:
1053:
1027:
1008:
977:
617:
596:
581:
545:primitive streak
533:secondary oocyte
521:
519:Top expressed in
514:
483:seminal vesicula
459:
457:Top expressed in
452:
431:
414:
404:
391:
380:
365:
358:
352:
341:
329:
313:
303:
290:
279:
264:
257:
251:
240:
226:
210:
204:
202:YAP1 - orthologs
155:
148:
125:
64:
58:
37:
36:
31:
19:
4822:
4821:
4817:
4816:
4815:
4813:
4812:
4811:
4792:
4791:
4790:
4785:
4769:
4746:
4713:
4681:Adaptor protein
4675:
4657:
4648:
4618:
4613:
4610:
4604:
4595:
4589:
4580:
4574:
4565:
4559:
4545:
4542:
4512:
4468:
4467:
4463:
4419:
4418:
4414:
4362:
4361:
4357:
4313:
4312:
4308:
4264:
4263:
4259:
4213:
4212:
4208:
4183:10.1038/nrc3876
4164:
4163:
4159:
4134:10.1038/nrd4161
4115:
4114:
4110:
4087:10.1038/nrc3458
4072:
4071:
4067:
4029:
4028:
4024:
3980:
3979:
3975:
3944:
3943:
3936:
3913:(5): 992β1009.
3900:
3899:
3892:
3840:
3839:
3835:
3797:
3796:
3792:
3756:
3755:
3748:
3717:(21): 2747β61.
3704:
3703:
3699:
3655:
3654:
3650:
3598:
3597:
3593:
3548:Current Biology
3541:
3540:
3536:
3505:(18): 4264β76.
3492:
3491:
3487:
3451:
3450:
3446:
3402:
3401:
3397:
3353:
3352:
3348:
3317:(12): 1285β97.
3304:
3303:
3299:
3255:
3254:
3250:
3219:(14): 1962β71.
3206:
3205:
3201:
3159:
3154:
3153:
3149:
3105:
3104:
3095:
3079:1854/LU-1256657
3051:
3050:
3046:
3010:
3009:
3005:
2961:
2960:
2956:
2910:
2909:
2905:
2859:
2858:
2854:
2823:(10): 1266β73.
2810:
2809:
2805:
2769:
2768:
2764:
2728:
2727:
2723:
2692:
2691:
2687:
2651:
2650:
2646:
2610:
2609:
2605:
2574:(10): 1726β36.
2561:
2560:
2556:
2533:(32): 4879β84.
2520:
2519:
2515:
2486:Cancer Research
2479:
2478:
2474:
2430:
2429:
2422:
2378:
2377:
2373:
2321:
2320:
2316:
2278:
2277:
2273:
2242:(10): 1229β41.
2229:
2228:
2221:
2177:
2176:
2172:
2136:
2135:
2131:
2079:
2078:
2074:
2044:
2043:
2039:
2009:
2008:
2004:
1950:
1949:
1945:
1901:
1900:
1896:
1874:
1873:
1866:
1853:
1852:
1848:
1835:
1834:
1830:
1818:
1809:
1797:
1788:
1784:
1735:
1723:
1713:after cerebral
1707:neuroprotective
1703:
1701:Neuroprotection
1694:
1682:
1677:
1661:
1620:
1615:
1564:gene expression
1560:14-3-3 proteins
1484:
1445:, known as the
1431:
1355:View/Edit Mouse
1350:View/Edit Human
1313:
1306:
1303:Location (UCSC)
1289:
1285:
1264:
1260:
1256:
1252:
1246:
1242:
1238:
1234:
1230:
1206:
1202:
1181:
1177:
1173:
1169:
1163:
1159:
1155:
1151:
1147:
1062:ENSG00000137693
955:
846:hippo signaling
719:
678:
639:protein binding
577:
568:
563:
559:
555:
551:
547:
543:
539:
535:
531:
517:
506:
501:
497:
493:
491:parietal pleura
489:
485:
481:
477:
473:
469:
455:
399:
386:
378:
368:
367:
366:
359:
339:
316:Gene location (
298:
285:
277:
267:
266:
265:
258:
236:
213:Gene location (
164:
151:
144:
73:
51:
17:
12:
11:
5:
4820:
4818:
4810:
4809:
4804:
4794:
4793:
4787:
4786:
4784:
4783:
4777:
4775:
4771:
4770:
4768:
4767:
4762:
4756:
4754:
4748:
4747:
4745:
4744:
4739:
4734:
4729:
4723:
4721:
4715:
4714:
4712:
4711:
4706:
4701:
4696:
4691:
4685:
4683:
4677:
4676:
4674:
4673:
4667:
4665:
4659:
4658:
4649:
4647:
4646:
4639:
4632:
4624:
4615:
4614:
4612:
4611:
4605:
4598:
4596:
4590:
4583:
4581:
4575:
4568:
4566:
4560:
4553:
4550:
4547:
4546:
4543:
4541:
4540:
4533:
4526:
4518:
4511:
4510:
4481:(2): 295β302.
4461:
4412:
4355:
4326:(12): 1300β5.
4306:
4257:
4206:
4157:
4108:
4065:
4022:
3973:
3934:
3890:
3853:(5): 3689β98.
3833:
3790:
3746:
3697:
3648:
3591:
3534:
3485:
3464:(5): 896β906.
3444:
3395:
3346:
3297:
3268:(4): 388β401.
3248:
3199:
3147:
3118:(4): 491β505.
3093:
3044:
3003:
2954:
2923:(9): 7018β26.
2903:
2872:(6): 4364β70.
2852:
2803:
2762:
2721:
2685:
2644:
2603:
2554:
2513:
2492:(3): 1089β98.
2472:
2443:(9): 2551β62.
2420:
2371:
2314:
2271:
2219:
2170:
2129:
2072:
2037:
2002:
1943:
1894:
1883:(8): 2145β52.
1864:
1846:
1828:
1807:
1785:
1783:
1780:
1779:
1778:
1757:
1734:
1733:External links
1731:
1722:
1719:
1702:
1699:
1693:
1690:
1681:
1678:
1676:
1673:
1660:
1657:
1619:
1616:
1614:
1611:
1548:phosphorylated
1483:
1480:
1463:amino terminus
1449:. Two splice
1443:protein domain
1430:
1427:
1362:
1361:
1358:
1357:
1352:
1342:
1341:
1335:
1334:
1331:
1330:
1328:
1326:
1319:
1318:
1311:
1304:
1300:
1299:
1296:
1295:
1281:
1280:
1274:
1271:
1270:
1248:
1247:
1221:
1217:
1216:
1213:
1212:
1198:
1197:
1191:
1188:
1187:
1165:
1164:
1138:
1134:
1133:
1130:
1129:
1121:
1120:
1114:
1111:
1110:
1102:
1101:
1095:
1089:
1088:
1085:
1084:
1076:
1075:
1069:
1066:
1065:
1057:
1056:
1050:
1044:
1043:
1040:
1039:
1031:
1030:
1024:
1021:
1020:
1012:
1011:
1005:
999:
998:
993:
988:
984:
983:
973:
972:
969:
968:
957:
956:
954:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
806:vasculogenesis
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
727:
725:
721:
720:
718:
717:
712:
707:
702:
697:
692:
686:
684:
680:
679:
677:
676:
671:
666:
661:
656:
651:
646:
641:
636:
630:
628:
624:
623:
613:
612:
609:
608:
605:
604:
601:
600:
593:
587:
586:
583:
582:
574:
573:
570:
569:
567:
566:
562:
558:
554:
550:
546:
542:
538:
537:primary oocyte
534:
530:
526:
523:
522:
511:
508:
507:
505:
504:
500:
496:
492:
488:
484:
480:
476:
472:
468:
467:saphenous vein
464:
461:
460:
448:
447:
439:
428:
422:
421:
418:RNA expression
410:
409:
406:
405:
397:
393:
392:
384:
381:
376:
370:
369:
360:
353:
347:
343:
342:
337:
331:
330:
322:
321:
309:
308:
305:
304:
296:
292:
291:
283:
280:
275:
269:
268:
259:
252:
246:
242:
241:
234:
228:
227:
219:
218:
206:
205:
162:
158:
157:
149:
141:
140:
136:
135:
132:
131:
128:
127:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4819:
4808:
4805:
4803:
4800:
4799:
4797:
4782:
4779:
4778:
4776:
4774:Other/unknown
4772:
4766:
4763:
4761:
4758:
4757:
4755:
4753:
4749:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4724:
4722:
4720:
4716:
4710:
4707:
4705:
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4686:
4684:
4682:
4678:
4672:
4669:
4668:
4666:
4664:
4660:
4656:
4652:
4645:
4640:
4638:
4633:
4631:
4626:
4625:
4622:
4608:
4602:
4597:
4593:
4587:
4582:
4578:
4572:
4567:
4563:
4557:
4552:
4548:
4539:
4534:
4532:
4527:
4525:
4520:
4519:
4516:
4506:
4502:
4497:
4492:
4488:
4484:
4480:
4476:
4472:
4465:
4462:
4457:
4453:
4448:
4443:
4439:
4435:
4431:
4427:
4423:
4416:
4413:
4408:
4404:
4399:
4394:
4390:
4386:
4382:
4378:
4374:
4370:
4366:
4359:
4356:
4351:
4347:
4342:
4337:
4333:
4329:
4325:
4321:
4317:
4310:
4307:
4302:
4298:
4293:
4288:
4284:
4280:
4277:(7): 827β33.
4276:
4272:
4268:
4261:
4258:
4253:
4249:
4244:
4239:
4234:
4229:
4225:
4221:
4217:
4210:
4207:
4202:
4198:
4193:
4188:
4184:
4180:
4176:
4172:
4168:
4161:
4158:
4153:
4149:
4144:
4139:
4135:
4131:
4127:
4123:
4119:
4112:
4109:
4104:
4100:
4096:
4092:
4088:
4084:
4081:(4): 246β57.
4080:
4076:
4069:
4066:
4061:
4057:
4053:
4049:
4045:
4041:
4037:
4033:
4026:
4023:
4018:
4014:
4009:
4004:
4000:
3996:
3992:
3988:
3984:
3977:
3974:
3969:
3965:
3961:
3957:
3954:(3): 917β23.
3953:
3949:
3941:
3939:
3935:
3930:
3926:
3921:
3916:
3912:
3908:
3904:
3897:
3895:
3891:
3886:
3882:
3877:
3872:
3868:
3864:
3860:
3856:
3852:
3848:
3844:
3837:
3834:
3829:
3825:
3821:
3817:
3813:
3809:
3806:(12): 780β3.
3805:
3801:
3794:
3791:
3786:
3782:
3777:
3772:
3768:
3764:
3760:
3753:
3751:
3747:
3742:
3738:
3733:
3728:
3724:
3720:
3716:
3712:
3708:
3701:
3698:
3693:
3689:
3684:
3679:
3675:
3671:
3668:(6): 642β55.
3667:
3663:
3659:
3652:
3649:
3644:
3640:
3635:
3630:
3626:
3622:
3618:
3614:
3610:
3606:
3602:
3595:
3592:
3587:
3583:
3578:
3573:
3569:
3565:
3561:
3557:
3554:(5): 311β21.
3553:
3549:
3545:
3538:
3535:
3530:
3526:
3522:
3518:
3513:
3508:
3504:
3500:
3496:
3489:
3486:
3481:
3477:
3472:
3467:
3463:
3459:
3455:
3448:
3445:
3440:
3436:
3431:
3426:
3422:
3418:
3415:(5): 888β95.
3414:
3410:
3406:
3399:
3396:
3391:
3387:
3382:
3377:
3373:
3369:
3365:
3361:
3357:
3350:
3347:
3342:
3338:
3333:
3328:
3324:
3320:
3316:
3312:
3308:
3301:
3298:
3293:
3289:
3284:
3279:
3275:
3271:
3267:
3263:
3259:
3252:
3249:
3244:
3240:
3235:
3230:
3226:
3222:
3218:
3214:
3210:
3203:
3200:
3195:
3191:
3187:
3183:
3178:
3173:
3170:(5): 528β39.
3169:
3165:
3158:
3151:
3148:
3143:
3139:
3134:
3129:
3125:
3121:
3117:
3113:
3109:
3102:
3100:
3098:
3094:
3089:
3085:
3080:
3075:
3071:
3067:
3064:(3): 461β72.
3063:
3059:
3055:
3048:
3045:
3040:
3036:
3031:
3026:
3023:(1): 128β34.
3022:
3018:
3014:
3007:
3004:
2999:
2995:
2990:
2985:
2981:
2977:
2973:
2969:
2965:
2958:
2955:
2950:
2946:
2941:
2936:
2931:
2926:
2922:
2918:
2914:
2907:
2904:
2899:
2895:
2890:
2885:
2880:
2875:
2871:
2867:
2863:
2856:
2853:
2848:
2844:
2839:
2834:
2830:
2826:
2822:
2818:
2814:
2807:
2804:
2799:
2795:
2790:
2785:
2781:
2777:
2773:
2766:
2763:
2758:
2754:
2749:
2744:
2740:
2736:
2732:
2725:
2722:
2717:
2713:
2709:
2705:
2702:(2): 469β79.
2701:
2697:
2689:
2686:
2681:
2677:
2672:
2667:
2663:
2659:
2655:
2648:
2645:
2640:
2636:
2631:
2626:
2622:
2618:
2614:
2607:
2604:
2599:
2595:
2590:
2585:
2581:
2577:
2573:
2569:
2565:
2558:
2555:
2550:
2546:
2541:
2536:
2532:
2528:
2524:
2517:
2514:
2509:
2505:
2500:
2495:
2491:
2487:
2483:
2476:
2473:
2468:
2464:
2459:
2454:
2450:
2446:
2442:
2438:
2434:
2427:
2425:
2421:
2416:
2412:
2407:
2402:
2398:
2394:
2391:(4): 879β90.
2390:
2386:
2382:
2375:
2372:
2367:
2363:
2359:
2355:
2350:
2345:
2341:
2337:
2333:
2329:
2325:
2318:
2315:
2310:
2306:
2302:
2298:
2294:
2290:
2286:
2282:
2275:
2272:
2267:
2263:
2258:
2253:
2249:
2245:
2241:
2237:
2233:
2226:
2224:
2220:
2215:
2211:
2206:
2201:
2197:
2193:
2190:(2): 215β22.
2189:
2185:
2181:
2174:
2171:
2166:
2162:
2157:
2152:
2148:
2144:
2140:
2133:
2130:
2125:
2121:
2117:
2113:
2108:
2103:
2099:
2095:
2091:
2087:
2083:
2076:
2073:
2068:
2064:
2060:
2056:
2053:(2): 1201β5.
2052:
2048:
2041:
2038:
2033:
2029:
2025:
2021:
2018:(12): 531β3.
2017:
2013:
2006:
2003:
1998:
1994:
1989:
1984:
1979:
1974:
1970:
1966:
1962:
1958:
1954:
1947:
1944:
1939:
1935:
1931:
1927:
1922:
1917:
1914:(3): 421β34.
1913:
1909:
1905:
1898:
1895:
1890:
1886:
1882:
1878:
1871:
1869:
1865:
1860:
1856:
1850:
1847:
1842:
1838:
1832:
1829:
1825:
1821:
1816:
1814:
1812:
1808:
1804:
1800:
1795:
1793:
1791:
1787:
1781:
1776:
1772:
1771:
1766:
1762:
1758:
1755:
1751:
1750:
1745:
1741:
1737:
1736:
1732:
1730:
1728:
1720:
1718:
1716:
1712:
1708:
1700:
1698:
1691:
1689:
1686:
1679:
1674:
1672:
1670:
1666:
1658:
1656:
1654:
1650:
1646:
1642:
1638:
1634:
1624:
1617:
1612:
1610:
1607:
1601:
1598:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1567:
1565:
1561:
1557:
1553:
1549:
1545:
1541:
1537:
1533:
1529:
1525:
1521:
1517:
1513:
1509:
1505:
1501:
1497:
1493:
1489:
1481:
1479:
1477:
1473:
1468:
1464:
1460:
1456:
1452:
1448:
1444:
1435:
1428:
1426:
1424:
1420:
1416:
1412:
1408:
1404:
1400:
1399:tumorigenesis
1396:
1392:
1388:
1384:
1380:
1376:
1372:
1368:
1356:
1351:
1347:
1343:
1340:
1336:
1329:
1327:
1324:
1320:
1316:
1312:
1309:
1305:
1301:
1294:
1292:
1288:
1282:
1278:
1275:
1269:
1267:
1263:
1259:
1255:
1249:
1245:
1241:
1237:
1233:
1229:
1225:
1222:
1218:
1211:
1209:
1205:
1199:
1195:
1192:
1186:
1184:
1180:
1176:
1172:
1166:
1162:
1158:
1154:
1150:
1146:
1142:
1139:
1137:RefSeq (mRNA)
1135:
1128:
1127:
1122:
1118:
1115:
1109:
1108:
1103:
1099:
1096:
1094:
1090:
1083:
1082:
1077:
1073:
1070:
1064:
1063:
1058:
1054:
1051:
1049:
1045:
1038:
1037:
1032:
1028:
1025:
1019:
1018:
1013:
1009:
1006:
1004:
1000:
997:
994:
992:
989:
985:
982:
978:
974:
967:
963:
958:
952:
949:
947:
944:
942:
939:
937:
936:heart process
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
728:
726:
723:
722:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
687:
685:
682:
681:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
631:
629:
626:
625:
622:
621:Gene ontology
618:
614:
602:
597:
594:
592:
588:
580:
575:
564:
560:
557:hair follicle
556:
552:
548:
544:
540:
536:
532:
528:
527:
524:
520:
515:
512:
502:
498:
494:
490:
486:
482:
478:
474:
470:
466:
465:
462:
458:
453:
450:
449:
446:
444:
440:
438:
437:
433:
432:
429:
427:
423:
419:
415:
411:
403:
398:
394:
390:
385:
375:
371:
364:
357:
351:
344:
336:
332:
328:
323:
319:
314:
310:
302:
297:
293:
289:
284:
274:
270:
263:
256:
250:
243:
239:
233:
229:
225:
220:
216:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
159:
154:
147:
142:
137:
126:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
4759:
4606:
4591:
4576:
4561:
4478:
4474:
4464:
4429:
4425:
4415:
4372:
4368:
4358:
4323:
4319:
4309:
4274:
4270:
4260:
4223:
4219:
4209:
4177:(2): 73β79.
4174:
4170:
4160:
4128:(1): 63β79.
4125:
4121:
4111:
4078:
4074:
4068:
4035:
4031:
4025:
3990:
3986:
3976:
3951:
3947:
3910:
3906:
3850:
3846:
3836:
3803:
3799:
3793:
3766:
3762:
3714:
3710:
3700:
3665:
3661:
3651:
3608:
3604:
3594:
3551:
3547:
3537:
3502:
3498:
3488:
3461:
3457:
3447:
3412:
3408:
3398:
3363:
3359:
3349:
3314:
3310:
3300:
3265:
3261:
3251:
3216:
3212:
3202:
3167:
3163:
3150:
3115:
3111:
3061:
3057:
3047:
3020:
3016:
3006:
2974:(1): 51β63.
2971:
2967:
2957:
2920:
2916:
2906:
2869:
2865:
2855:
2820:
2816:
2806:
2779:
2775:
2765:
2738:
2734:
2724:
2699:
2695:
2688:
2661:
2657:
2647:
2620:
2616:
2606:
2571:
2567:
2557:
2530:
2526:
2516:
2489:
2485:
2475:
2440:
2436:
2388:
2384:
2374:
2334:(1): 103β8.
2331:
2328:FEBS Letters
2327:
2317:
2284:
2280:
2274:
2239:
2235:
2187:
2183:
2173:
2146:
2142:
2132:
2092:(2): 153β7.
2089:
2086:FEBS Letters
2085:
2075:
2050:
2046:
2040:
2015:
2011:
2005:
1960:
1956:
1946:
1911:
1907:
1897:
1880:
1876:
1858:
1849:
1840:
1831:
1768:
1747:
1726:
1724:
1704:
1695:
1687:
1683:
1665:shear stress
1662:
1629:
1602:
1599:
1583:amphiregulin
1568:
1485:
1440:
1421:is a potent
1418:
1378:
1374:
1370:
1366:
1365:
1287:NP_001164618
1284:
1262:NP_001269030
1258:NP_001269029
1254:NP_001269028
1251:
1244:NP_001269027
1240:NP_001269026
1236:NP_001181974
1232:NP_001181973
1228:NP_001123617
1204:NM_001171147
1201:
1179:NM_001282101
1175:NM_001282100
1171:NM_001282099
1168:
1161:NM_001282098
1157:NM_001282097
1153:NM_001195045
1149:NM_001195044
1145:NM_001130145
1124:
1105:
1079:
1060:
1034:
1015:
995:
990:
441:
434:
299:102,233,424
286:102,110,447
161:External IDs
72:
4544:PDB gallery
3366:(1): 1β17.
1618:Biochemical
1455:amino acids
695:nucleoplasm
499:pericardium
487:human penis
379:9|9 A1
139:Identifiers
4796:Categories
1826:, May 2017
1805:, May 2017
1782:References
1613:Regulation
1476:PDZ domain
1403:SH3 domain
445:(ortholog)
400:8,004,597
387:7,932,000
182:HomoloGene
2568:Structure
1721:Mutations
1556:cytoplasm
1496:apoptosis
1488:oncogenic
1447:WW domain
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1391:apoptotic
1291:NP_033560
1266:NP_006097
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