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Sweating causes lesions to form, but lesions aggravated by sweat usually return to "normal" fairly quickly—avoiding sweat is not considered a reason to avoid exercise. Minor outbreaks can be controlled with prescription strength topical cortisone creams. More severe eruptions usually clear up after
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This condition was first reported in 1975 by the
American dermatopathologist, Ralph Wier Grover (1920–2008) while working at Franklin Hospital in New York. He described and examined around 40 patients having the characteristic signs of the disease, which now bears his name.
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The prevalence and incidence of Grover's disease have not been firmly established. In a study from
Switzerland, Grover's disease was diagnosed in just 24 of more than 30,000 skin biopsies. Grover's disease is mainly seen in males over the age of forty.
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The itchy eruption lasts an average of 10–12 months. It is characterized by papules and papulovesicles with excoriations occurring on the chest, back, lower sternum, arms, and thighs. The papules are most commonly found on the mid chest.
202:
with or without dyskeratosis. Once confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient". However it may last much longer. Nevertheless, it is not to be confused with
333:
Grover's disease affects chiefly white adults in the fifth decade or later, and appears to be around 1.6 to 2.1 times more common in men than in women. Grover's disease appears less commonly in darker-skinned individuals.
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Grover's disease often starts quite suddenly. There are intensely itchy spots on the central back, mid chest and occasionally elsewhere. Frequently, it follows sweating or some unexpected heat stress.
491:
Grover RW, Rosenbaum R. The association of transient acantholytic dermatosis with other skin diseases. J Am Acad
Dermatol. 1984 Aug;11(2 Pt 1):253-6. doi: 10.1016/s0190-9622(84)70160-5. PMID 6237126.
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Sometimes the features of Grover's are found in people who do not itch or have a conspicuous rash. Most of the people with Grover's who visit a dermatologist, however, itch a lot.
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Grover's may be suspected by its appearance, but since it has such a characteristic appearance under the microscope a shave skin or punch biopsy is often performed.
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The cause of Grover's disease is unknown. Suspected triggers of disease activity include heat and sweating, sunlight, and adverse reaction to medications as well as
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or tetracycline. If these fail or the outbreak is severe, PUVA phototherapy treatments, antifungal medication and cortisone injections are alternatives.
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277:. One series of 300 patients with Grover's disease reported an association with other coexisting dermatoses including
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Scheinfeld NS, Mones J (2006). "Seasonal variation of transient acantholytic dyskeratosis (Grover's disease)".
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benign papular acantholytic dermatosis, transient acantholytic dermatosis, persistent acantholytic dermatosis
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Some research has suggested a correlation of Grover's disease with mercury toxicity in which case
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Dantzig PI (2005). "Age-Related
Macular Degeneration and Cutaneous Signs of Mercury Toxicity".
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Some cases of Grover's disease have been associated with medications such as
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http://www.uptodate.com/patients/content/topic.do?topicKey=~JmwJAF8q.xf7GjV
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of transient acantholytic dermatosis, showing subcorneal separation and
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516:"Grover's Disease - American Osteopathic College of Dermatology (AOCD)"
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293:, bacterial and viral infections, and occasionally, malignancies.
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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Krivo, James M.; Ackerman, A. Bernard; Lepaw, Marvin I. (2010).
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289:. Finally, smaller series have detailed an association with
618:"Could I Have Grover's Disease? Is It Just a Skin Rash?"
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46:. Unsourced material may be challenged and removed.
469:Ferri's Color Atlas and Text of Clinical Medicine
637:Journal of the American Academy of Dermatology
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391:Fitzpatrick's Dermatology in General Medicine
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106:Learn how and when to remove this message
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205:relapsing linear acantholytic dermatosis
1114:Chronic blistering cutaneous conditions
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310:treatment for one to three months with
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44:adding citations to reliable sources
1093:PUVA-induced acrobullous dermatosis
633:"In memoriam: Dr Ralph Wier Grover"
55:"Transient acantholytic dermatosis"
552:10.1097/01.jom.0000228351.74230.52
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938:Transient acantholytic dermatosis
671:Transient acantholytic dermatosis
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198:characterized histologically by
20:
1007:Epidermolysis bullosa acquisita
584:Cutaneous and Ocular Toxicology
31:needs additional citations for
1:
1030:Linear IgA bullous dermatosis
1088:Bullous lupus erythematosus
916:Intraepidermal neutrophilic
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649:10.1016/j.jaad.2008.11.899
471:(1st ed.). Saunders.
425:10.1016/j.jaad.2006.01.029
393:. (6th ed.). McGraw-Hill.
389:Freedberg, et al. (2003).
227:Advanced case, fifth month
219:Advanced case, third month
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367:Dermatology: 2-Volume Set
263:sulfadoxine-pyrimethamine
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1065:Dermatitis herpetiformis
893:Paraneoplastic pemphigus
454:www.thedoctorsdoctor.com
1083:Porphyria cutanea tarda
875:Pemphigus erythematosus
807:Vesiculobullous disease
533:Dantzig PI (Jul 2006).
319:Dimercaptosuccinic acid
997:Gestational pemphigoid
985:Cicatricial pemphigoid
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673:at Wikimedia Commons
596:10.1081/cus-200046177
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1076:classified elsewhere
1002:Pemphigoid nodularis
369:. St. Louis: Mosby.
291:pyoderma gangrenosum
190:) is a polymorphic,
40:improve this article
911:Subcorneal pustular
871:Pemphigus foliaceus
539:J Occup Environ Med
467:Ferri, FF. (2009).
980:Bullous pemphigoid
846:Pemphigus vegetans
842:Pemphigus vulgaris
750:External resources
450:"Grover's Disease"
413:J Am Acad Dermatol
283:contact dermatitis
248:ionizing radiation
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211:Signs and symptoms
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51:Find sources:
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29:This article
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815:Acantholysis
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325:Epidemiology
321:might help.
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256:hemodialysis
250:, end-stage
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200:acantholysis
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151:acantholysis
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38:Please help
33:verification
30:
1074:In diseases
168:Dermatology
129:Other names
1108:Categories
952:Pemphigoid
856:of Neumann
735:DiseasesDB
545:(7): 656.
347:References
196:dermatosis
147:Micrograph
66:newspapers
1035:Childhood
990:Localised
830:Pemphigus
820:epidermis
759:eMedicine
305:Treatment
297:Diagnosis
271:cetuximab
267:ribavirin
163:Specialty
604:73170429
569:42780776
561:16832218
520:aocd.org
433:16844509
312:Accutane
192:pruritic
1057:bullous
729:C537306
590:: 3–9.
338:History
80:scholar
1055:Other
957:dermis
643:: e3.
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273:, and
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931:Other
740:32883
718:694.8
703:L11.1
600:S2CID
565:S2CID
242:Cause
87:JSTOR
73:books
724:MeSH
713:9-CM
557:PMID
473:ISBN
429:PMID
395:ISBN
371:ISBN
59:news
1019:IgA
969:IgG
709:ICD
694:ICD
645:doi
592:doi
547:doi
421:doi
42:by
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