150:
36:
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562:
501:
Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Zhang J, Hu G (August 2006). "Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake".
381:
Ma D, Tian H, Zou G (January 1999). "Asymmetric
Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors".
555:
1574:
48:
548:
1636:
1570:
417:
Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW (January 2002). "Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens".
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571:
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72:
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350:"Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists"
129:
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1113:
965:
326:
265:
InChI=1S/C10H12NO5P/c11-10(9(12)13)4-3-6-5-7(17(14,15)16)1-2-8(6)10/h1-2,5H,3-4,11H2,(H,12,13)(H2,14,15,16)
749:
615:
118:
145:
19:
This article is about the metabotropic glutamate receptor antagonist. For the cannabinoid drug, see
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348:
Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT (May 1997).
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454:"The origin and neuronal function of in vivo nonsynaptic glutamate"
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610:
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Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW (October 2002).
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The
Journal of Pharmacology and Experimental Therapeutics
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63:
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16:Chemical compound used in neuroscience research
1630:
556:
8:
354:Bioorganic & Medicinal Chemistry Letters
325:), and has been useful in the study of this
26:
1637:
1623:
1194:
887:
587:
563:
549:
541:
293:1-Amino-5-phosphonoindan-1-carboxylic acid
148:
97:
80:1-Amino-5-phosphonoindan-1-carboxylic acid
34:
1575:Glutamate metabolism/transport modulators
1482:Tooltip Metabotropic glutamate receptor 8
1383:Tooltip Metabotropic glutamate receptor 7
1311:Tooltip Metabotropic glutamate receptor 6
1207:Tooltip Metabotropic glutamate receptor 4
1058:Tooltip Metabotropic glutamate receptor 3
900:Tooltip Metabotropic glutamate receptor 2
714:Tooltip Metabotropic glutamate receptor 5
600:Tooltip Metabotropic glutamate receptor 1
477:
365:
316:group II metabotropic glutamate receptors
1571:Ionotropic glutamate receptor modulators
340:
262:
242:
144:
77:
25:
117:
7:
1587:
1585:
1114:Pomaglumetad methionil (LY-2140023)
966:Pomaglumetad methionil (LY-2140023)
1609:. You can help Knowledge (XXG) by
470:10.1523/JNEUROSCI.22-20-09134.2002
192:
21:APICA (synthetic cannabinoid drug)
14:
245:O=P(O)(O)c(c2)ccc1c2CCC1(N)C(O)=O
1589:
504:Journal of Neuroscience Research
384:The Journal of Organic Chemistry
183:
177:
1510:Positive allosteric modulators:
1461:Negative allosteric modulators:
1250:Positive allosteric modulators:
1168:Negative allosteric modulators:
1032:Negative allosteric modulators:
975:Positive allosteric modulators:
831:Negative allosteric modulators:
774:Positive allosteric modulators:
572:Metabotropic glutamate receptor
270:Key:ZNQZXIHSJUDIKL-UHFFFAOYSA-N
1656:Drugs not assigned an ATC code
186:
171:
1:
1567:Receptor/signaling modulators
367:10.1016/S0960-894X(97)00177-7
458:The Journal of Neuroscience
1692:
1671:MGlu3 receptor antagonists
1666:MGlu2 receptor antagonists
1584:
161:Chemical and physical data
18:
1676:Nervous system drug stubs
1560:
1099:LY-404,039 (pomaglumetad)
946:LY-404,039 (pomaglumetad)
278:
253:
233:
68:
33:
1601:article relating to the
978:JNJ-40411813 (ADX-71149)
431:10.1124/jpet.300.1.162
310:. It is a selective
30:
1618:
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1582:
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516:10.1002/jnr.20897
396:10.1021/jo981297a
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224:Interactive image
130:CompTox Dashboard
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360:(9): 1195โ1198.
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303:that is used in
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899:
896:
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765:Quisqualic acid
713:
710:
700:
631:Quisqualic acid
599:
596:
577:
569:
539:
500:
499:
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464:(20): 9134โ41.
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24:
17:
12:
11:
5:
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1661:1-Aminoindanes
1658:
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1627:
1619:
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1603:nervous system
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390:(1): 120โ125.
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1234:
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1205:
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1187:
1177:
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1127:
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1123:
1120:
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1089:Ibotenic acid
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1064:
1063:
1061:
1056:
1047:
1041:
1038:
1036:
1033:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
989:
986:
983:
982:
979:
976:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
936:Ibotenic acid
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
906:
905:
903:
898:
889:
886:
884:
880:
870:
867:
865:
862:
860:
857:
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852:
850:
847:
845:
842:
840:
837:
835:
832:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
782:
781:
778:
775:
771:
768:
766:
763:
761:
760:Ibotenic acid
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
720:
719:
717:
712:
703:
697:
694:
692:
689:
687:
684:
682:
679:
677:
676:Cyclothiazide
674:
672:
669:
667:
664:
661:
660:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
626:Ibotenic acid
624:
622:
619:
617:
614:
612:
609:
606:
605:
603:
598:
589:
586:
584:
580:
576:
573:
566:
561:
559:
554:
552:
547:
546:
543:
533:
529:
525:
521:
517:
513:
510:(2): 268โ77.
509:
505:
497:
494:
489:
485:
480:
475:
471:
467:
463:
459:
455:
448:
445:
440:
436:
432:
428:
425:(1): 162โ71.
424:
420:
413:
410:
405:
401:
397:
393:
389:
385:
377:
374:
368:
363:
359:
355:
351:
344:
341:
335:
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331:
328:
324:
317:
313:
309:
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302:
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277:
268:
263:
259:
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210:
203:
201:
197:
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159:
151:
147:
143:
142:
140:
131:
127:
120:
116:
115:
113:
111:
107:
100:
96:
95:
93:
91:
87:
78:
74:
67:
62:
55:
54:
52:
50:
46:
43:Clinical data
41:
37:
32:
22:
1611:expanding it
1596:
1563:
1562:
1520:Antagonists:
1519:
1509:
1489:
1460:
1419:Antagonists:
1418:
1390:
1337:Antagonists:
1336:
1318:
1265:Antagonists:
1264:
1249:
1214:
1167:
1128:
1126:Antagonists:
1125:
1119:Talaglumetad
1065:
1031:
987:
985:Antagonists:
984:
974:
971:Talaglumetad
907:
844:Dipraglurant
839:Basimglurant
830:
784:Antagonists:
783:
773:
721:
663:Antagonists:
662:
607:
507:
503:
496:
461:
457:
447:
422:
418:
412:
387:
383:
376:
357:
353:
343:
305:neuroscience
296:
292:
291:
280:
119:ChEMBL277961
1246:VU-0155,041
1171:Decoglurant
1035:Decoglurant
869:Raseglurant
817:Remeglurant
802:Mavoglurant
666:BAY 36-7620
207: gยทmol
64:Identifiers
1650:Categories
1513:AZ12216052
1253:Foliglurax
1241:VU-001,171
1154:LY-341,495
1149:LY-307,452
1104:LY-487,379
1094:LY-379,268
1013:LY-341,495
1008:LY-307,452
956:LY-566,332
951:LY-487,379
941:LY-379,268
797:LY-344,545
777:LSN2463359
686:LY-456,236
681:LY-367,385
575:modulators
336:References
312:antagonist
212:3D model (
200:Molar mass
90:ChemSpider
73:IUPAC name
1564:See also:
1498:Glutamate
1490:Agonists:
1412:LSP2-9166
1399:Glutamate
1391:Agonists:
1322:Glutamate
1319:Agonists:
1231:LSP2-9166
1218:Glutamate
1215:Agonists:
1190:Group III
1176:RO4491533
1084:Glutamate
1079:Eglumegad
1066:Agonists:
1040:RO4491533
931:Glutamate
926:Eglumegad
908:Agonists:
755:Glutamate
730:ADX-47273
722:Agonists:
646:Ro67-7476
641:Ro67-4853
636:Ro01-6128
621:Glutamate
608:Agonists:
330:subfamily
1548:UBP-1112
1464:ADX71743
1452:UBP-1112
1365:UBP-1112
1293:UBP-1112
1164:MGS-0039
1109:MGS-0028
1023:MGS-0039
961:MGS-0028
883:Group II
827:SIB-1893
822:SIB-1757
812:NPS-2390
696:NPS-2390
656:Theanine
532:44863411
524:16752416
488:12388621
439:11752112
404:11674092
327:receptor
314:for the
308:research
283:(verify)
49:ATC code
854:GRN-529
849:Fenobam
834:AZD9272
770:VU-1545
671:CPCCOEt
583:Group I
479:6757683
299:) is a
205:257.182
167:Formula
99:3881975
1457:XAP044
1394:AMN082
1074:DCG-IV
1069:CBiPES
1028:PCCG-4
921:DCG-IV
916:CBiPES
530:
522:
486:
476:
437:
402:
238:SMILES
110:ChEMBL
1605:is a
1597:This
1475:mGluR
1432:MMPIP
1376:mGluR
1304:mGluR
1236:PHCCC
1200:mGluR
1144:HYDIA
1134:CECXG
1129:APICA
1051:mGluR
1003:HYDIA
993:CECXG
988:APICA
893:mGluR
792:DMeOB
735:CDPPB
707:mGluR
651:VU-71
593:mGluR
528:S2CID
320:mGluR
297:APICA
258:InChI
214:JSmol
28:APICA
1607:stub
1599:drug
1543:MTPG
1538:MSOP
1533:MPPG
1528:MAP4
1523:CPPG
1506:-AP4
1493:DCPG
1447:MTPG
1442:MSOP
1437:MPPG
1427:MAP4
1422:CPPG
1407:-AP4
1360:MTPG
1355:MSOP
1350:MPPG
1345:MAP4
1340:CPPG
1330:-AP4
1288:MTPG
1283:MSOP
1278:MPPG
1273:MAP4
1268:CPPG
1258:MPEP
1226:-AP4
1159:MCPG
1139:EGLU
1018:MCPG
998:EGLU
911:BINA
864:MTEP
859:MPEP
807:MCPG
787:CTEP
750:DHPG
740:CHPG
725:ACPD
691:MCPG
616:DHPG
611:ACPD
520:PMID
484:PMID
435:PMID
400:PMID
301:drug
56:none
745:DFB
512:doi
474:PMC
466:doi
427:doi
423:300
392:doi
362:doi
322:2/3
135:EPA
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1573:โข
1569:โข
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1459:;
1248:;
1166:;
1030:;
973:;
829:;
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526:.
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462:22
460:.
456:.
433:.
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388:64
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181:12
175:10
1638:e
1631:t
1624:v
1613:.
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1477:8
1405:L
1378:7
1328:L
1306:6
1224:L
1202:4
1053:3
895:2
709:5
595:1
564:e
557:t
550:v
534:.
514::
490:.
468::
441:.
429::
406:.
394::
370:.
364::
358:7
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216:)
193:P
190:5
187:O
184:N
178:H
172:C
137:)
133:(
23:.
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