234:
165:
26:
354:
528:
Taniguchi A, Tsuchida S, Kuno S, Mita M, Machida T, Ioritani N, Terai C, Yamanaka H, Kamatani N (2004). "Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine urolithiasis".
429:
therapy appears to be effective. 2, 8-dihydroxyadenine formation can be easily controlled with allopurinol, which is administered in a dose of 300 mg/day in adults (10 mg/kg/day in children) in the absence of kidney failure.
367:
283:
102:
489:
Diculescu VC, Piedade JA, Oliveira-Brett AM (2007). "Electrochemical behaviour of 2,8-dihydroxyadenine at a glassy carbon electrode".
447:
Gault MH, Simmonds HA, Snedden W, Dow D, Churchill DN, Penney H (1981-12-24). "Urolithiasis Due to 2,8-Dihydroxyadenine in an Adult".
394:
402:
248:
374:
212:
178:
421:. The condition primarily presents as renal obstructive disease, but some patients have presented with advanced
172:
160:
406:
38:
401:
2,8-dihydroxyadenine is excreted in the urine because of a deficiency in the adenine salvage enzyme
229:
68:
554:
409:; the homozygous state is associated with high urinary levels of 2,8-dihydroxyadenine and with
589:
546:
516:
472:
464:
414:
610:
579:
538:
506:
498:
456:
306:
142:
78:
233:
164:
122:
422:
418:
345:
604:
502:
153:
558:
410:
200:
460:
426:
584:
567:
25:
333:
133:
468:
593:
550:
520:
542:
476:
257:
InChI=1S/C5H5N5O2/c6-2-1-3(9-4(11)7-1)10-5(12)8-2/h(H5,6,7,8,9,10,11,12)
390:
267:
InChI=1/C5H5N5O2/c6-2-1-3(9-4(11)7-1)10-5(12)8-2/h(H5,6,7,8,9,10,11,12)
187:
511:
398:
344:
Except where otherwise noted, data are given for materials in their
113:
101:
91:
217:
568:"2,8-Dihydroxyadenine renal stones in a 41-year-old man"
362:
199:
77:
8:
232:
163:
141:
17:
583:
566:Wilkinson H, Samuell C, Stower M (2004).
510:
439:
288:
253:
228:
177:
154:
531:Nucleosides Nucleotides Nucleic Acids
260:Key: XFBOJHLYDJZYSP-UHFFFAOYSA-N
121:
7:
270:Key: XFBOJHLYDJZYSP-UHFFFAOYAF
190:
395:2,8 dihydroxy-adenine urolithiasis
14:
403:adenine phosphoribosyltransferase
503:10.1016/j.bioelechem.2006.03.015
405:. The defect is inherited as an
352:
24:
449:New England Journal of Medicine
348:(at 25 °C , 100 kPa).
1:
291:O=C2N/C/1=N/C(=O)N\C(=C\1N2)N
461:10.1056/NEJM198112243052608
627:
585:10.1258/000456304322880087
417:formation, and potential
407:autosomal recessive trait
342:
299:
279:
244:
61:
37:
32:
23:
543:10.1081/NCN-200027393
397:. The poorly soluble
393:which accumulates in
338:167.126
19:2,8-Dihydroxyadenine
387:2,8-Dihydroxyadenine
179:2,8-dihydroxyadenine
39:Preferred IUPAC name
491:Bioelectrochemistry
389:is a derivative of
20:
375:Infobox references
18:
455:(26): 1570–1572.
383:Chemical compound
381:
380:
213:CompTox Dashboard
103:Interactive image
618:
597:
587:
572:Ann Clin Biochem
562:
524:
514:
481:
480:
444:
365:
359:
356:
355:
307:Chemical formula
237:
236:
221:
219:
203:
192:
181:
167:
156:
145:
125:
105:
81:
28:
21:
626:
625:
621:
620:
619:
617:
616:
615:
601:
600:
578:(Pt 2): 160–1.
565:
537:(8–9): 1141–5.
527:
488:
485:
484:
446:
445:
441:
436:
384:
377:
372:
371:
370: ?)
361:
357:
353:
349:
327:
323:
319:
315:
309:
295:
292:
287:
286:
275:
272:
271:
268:
262:
261:
258:
252:
251:
240:
222:
215:
206:
193:
148:
128:
108:
95:
84:
71:
57:
56:
12:
11:
5:
624:
622:
614:
613:
603:
602:
599:
598:
563:
525:
483:
482:
438:
437:
435:
432:
423:kidney failure
419:nephrotoxicity
382:
379:
378:
373:
351:
350:
346:standard state
343:
340:
339:
336:
330:
329:
325:
321:
317:
313:
310:
305:
302:
301:
297:
296:
294:
293:
290:
282:
281:
280:
277:
276:
274:
273:
269:
266:
265:
263:
259:
256:
255:
247:
246:
245:
242:
241:
239:
238:
230:DTXSID80184453
225:
223:
211:
208:
207:
205:
204:
196:
194:
186:
183:
182:
175:
169:
168:
158:
150:
149:
147:
146:
138:
136:
130:
129:
127:
126:
118:
116:
110:
109:
107:
106:
98:
96:
89:
86:
85:
83:
82:
74:
72:
67:
64:
63:
59:
58:
42:
41:
35:
34:
30:
29:
13:
10:
9:
6:
4:
3:
2:
623:
612:
609:
608:
606:
595:
591:
586:
581:
577:
573:
569:
564:
560:
556:
552:
548:
544:
540:
536:
532:
526:
522:
518:
513:
508:
504:
500:
496:
492:
487:
486:
478:
474:
470:
466:
462:
458:
454:
450:
443:
440:
433:
431:
428:
424:
420:
416:
412:
408:
404:
400:
396:
392:
388:
376:
369:
364:
347:
341:
337:
335:
332:
331:
311:
308:
304:
303:
298:
289:
285:
278:
264:
254:
250:
243:
235:
231:
227:
226:
224:
214:
210:
209:
202:
198:
197:
195:
189:
185:
184:
180:
176:
174:
171:
170:
166:
162:
159:
157:
155:ECHA InfoCard
152:
151:
144:
140:
139:
137:
135:
132:
131:
124:
120:
119:
117:
115:
112:
111:
104:
100:
99:
97:
93:
88:
87:
80:
76:
75:
73:
70:
66:
65:
60:
54:
50:
47:-purine-2,8(7
46:
40:
36:
31:
27:
22:
16:
575:
571:
534:
530:
497:(1): 141–6.
494:
490:
452:
448:
442:
411:crystalluria
386:
385:
123:CHEBI:183641
62:Identifiers
52:
48:
44:
15:
427:Allopurinol
300:Properties
161:100.045.584
512:10316/5065
434:References
334:Molar mass
134:ChemSpider
90:3D model (
79:30377-37-8
69:CAS Number
469:0028-4793
43:6-Amino-1
605:Category
594:15025810
559:38050144
551:15571218
521:16713382
415:calculus
611:Purines
477:7311997
391:adenine
368:what is
366: (
328:
188:PubChem
55:)-dione
592:
557:
549:
519:
475:
467:
399:purine
363:verify
360:
284:SMILES
33:Names
555:S2CID
249:InChI
201:92268
143:83302
114:ChEBI
92:JSmol
590:PMID
547:PMID
517:PMID
473:PMID
465:ISSN
173:MeSH
580:doi
539:doi
507:hdl
499:doi
457:doi
453:305
218:EPA
191:CID
607::
588:.
576:41
574:.
570:.
553:.
545:.
535:23
533:.
515:.
505:.
495:70
493:.
471:.
463:.
451:.
425:.
413:,
51:,9
596:.
582::
561:.
541::
523:.
509::
501::
479:.
459::
358:N
326:2
324:O
322:5
320:N
318:5
316:H
314:5
312:C
220:)
216:(
94:)
53:H
49:H
45:H
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
