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Weekes D, Miller MD, Krishna SS, McMullan D, McPhillips TM, Acosta C, Canaves JM, Elsliger MA, Floyd R, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, Kreusch A, Morse AT, Quijano K, Spraggon G, van den Bedem H, Wolf G, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA
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Anantharaman V, Koonin EV, Aravind L (April 2001). "Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains".
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of de novo NAD synthesis pathway regulators. TM1602 has an N-terminal DNA-binding domain and a C-terminal 3H
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residues. The 3H domain appears to be a smarr molecure-binding domain, based on its occurrence with other
523:
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294:"Crystal structure of a transcription regulator (TM1602) from Thermotoga maritima at 2.3 A resolution"
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crystal structure of transcriptional regulator (tm1602) from thermotoga maritima at 2.3 a resolution
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235:, nicotinic acid, or other substrate/products. The 3H domain has a 2-layer alpha/beta sandwich
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domain. The N-terminal domain appears to bind to the NAD
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This article incorporates text from the public domain
231:operon, while the C-terminal 3H domain may bind to
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211:is a DNA-binding protein thought to belong to a
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112:Available protein structures:
199:regulators from the biotin
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172:In molecular biology, the
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195:carrying this domain are
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223:region and repress the
205:transcription regulator
270:10.1006/jmbi.2001.4508
180:named after its three
209:Thermotoga maritima
311:10.1002/prot.21221
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161:structure summary
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182:highly conserved
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699:Protein domains
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383:Protein domains
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197:transcriptional
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292:(April 2007).
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264:(5): 1271–92.
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178:protein domain
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16:Protein domain
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304:(1): 247–52.
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258:J. Mol. Biol
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233:nicotinamide
229:biosynthesis
224:
208:
207:TM1602 from
203:family. The
173:
171:
678:zinc finger
39:Identifiers
243:References
217:regulatory
191:. Several
124:structures
566:EcoEI_R_C
348:IPR004173
201:repressor
185:histidine
174:3H domain
82:PDOC00449
70:IPR004173
693:Category
344:InterPro
328:42634714
320:17256761
298:Proteins
278:11292341
221:promoter
193:proteins
141:RCSB PDB
65:InterPro
596:Kringle
489:CGI-121
459:BTB/POZ
225:de novo
189:domains
77:PROSITE
58:PF02829
326:
318:
276:
213:family
156:PDBsum
130:
120:
102:SUPFAM
44:Symbol
611:NACHT
534:Pyrin
514:Death
479:Cache
414:ADF-H
324:S2CID
176:is a
98:SCOPe
89:SCOP2
663:WD40
658:TRIO
591:HEAT
586:FYVE
581:FGGY
576:ENTH
556:DHR2
551:DHR1
546:DHHC
529:CARD
509:CVHN
464:BZIP
439:BESS
424:ARID
419:ANTH
404:ACDC
342:and
340:Pfam
316:PMID
274:PMID
237:fold
227:NAD
149:PDBj
145:PDBe
128:ECOD
118:Pfam
94:1j5y
53:Pfam
673:YTH
653:SUN
648:SH3
643:SH2
628:PDZ
621:LOV
616:PAS
606:LRR
601:LIM
571:EF1
541:DEP
524:DED
504:CUT
499:CUB
494:CRM
484:CBS
454:BPS
449:BMC
444:BIR
434:BEN
429:BAR
409:ACT
399:ABM
306:doi
266:doi
262:307
136:PDB
695::
668:X8
638:PX
633:PH
561:DM
519:DD
474:C2
469:C1
394:3H
346::
322:.
314:.
302:67
300:.
296:.
272:.
260:.
239:.
147:;
143:;
126:/
100:/
96:/
47:3H
22:3H
375:e
368:t
361:v
330:.
308::
280:.
268::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
