Knowledge (XXG)

4-Hydroxy-4-methylpentanoic acid

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166: 40: 1345: 291: 1390: 407: 247: 1414: 1014: 931: 319:. The molecule has been synthesized and tested on animals in order to further research the effects of GHB. UMB68 has been shown to bind selectively to the 1383: 1316: 400: 1323: 1182: 1429: 1376: 1309: 761: 267: 841: 744: 327:
receptors. As such, it can provide a useful tool in studying the pharmacology of the GHB receptor in absence of GABAergic effects.
876: 393: 846: 1126: 1103: 68: 1424: 1419: 1302: 793: 776: 125: 145: 649: 1409: 316: 233: 629: 471: 531: 486: 1139: 949: 831: 511: 501: 481: 506: 430: 684: 1248: 694: 1210: 436: 345:"A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand" 806: 674: 161: 39: 1352: 664: 654: 639: 496: 85: 659: 644: 634: 984: 881: 782: 422: 372: 31: 816: 689: 516: 491: 17: 679: 364: 114: 1360: 704: 541: 536: 343:
Wu H, Zink N, Carter LP, Mehta AK, Hernandez RJ, Ticku MK, Lamb R, France CP, Coop A (2003).
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InChI=1S/C6H12O3/c1-6(2,9)4-3-5(7)8/h9H,3-4H2,1-2H3,(H,7,8)
315:) is a tertiary alcohol, similar in structure to the drug 1364: 1127: 1104: 298: 745: 349:
Journal of Pharmacology and Experimental Therapeutics
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Tooltip Vesicular inhibitory amino acid transporter
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Tooltip Sodium-coupled monocarboxylate transporters
930: 792: 775: 743: 446: 429: 221: 208: 181: 176: 144: 124: 104: 84: 59: 51: 46: 323:ligand in binding assays, yet does not bind to 93: 1249: 1384: 1211: 417: 401: 8: 1188:Tooltip Hydroxyacid-oxoacid transhydrogenase 30: 1391: 1377: 1099: 789: 443: 408: 394: 386: 164: 113: 133: 1132:Tooltip 4-Hydroxybutyrate dehydrogenase 1109:Tooltip Succinic semialdehyde reductase 335: 272: 252: 160: 73: 753:Tooltip γ-Aminobutyric acid B receptor 29: 7: 1341: 1339: 799:Tooltip Monocarboxylate transporters 448: 1415:Drugs acting on the nervous system 1363:. You can help Knowledge (XXG) by 25: 1343: 309:4-Hydroxy-4-methylpentanoic acid 193: 76:4-Hydroxy-4-methylpentanoic acid 55:4-Hydroxy-4-methylpentanoic acid 38: 32:4-Hydroxy-4-methylpentanoic acid 18:4-hydroxy-4-methylpentanoic acid 591:Positive allosteric modulators: 280:Key:PQJUMPXLDAZULJ-UHFFFAOYSA-N 1254:Tooltip Aldehyde dehydrogenase 199: 187: 1: 1317:Glutamate receptor modulators 1303:Receptor/signaling modulators 1234:Fomepizole (4-methylpyrazole) 1216:Tooltip Alcohol dehydrogenase 1324:Glycine receptor modulators 477:Aceburic acid (GHB acetate) 1446: 1338: 177:Chemical and physical data 1430:Nervous system drug stubs 1294: 288: 263: 243: 64: 37: 1355:article relating to the 1310:GABA receptor modulators 361:10.1124/jpet.102.046797 1425:GHB receptor agonists 1140:α-Ketoisocaproic acid 453:Tooltip GHB receptor 1420:Gamma hydroxy acids 612:Gabazine (SR-95531) 34: 975:Mesalazine (5-ASA) 882:Phenylpyruvic acid 512:GHV (4-methyl-GHB) 1410:Tertiary alcohols 1372: 1371: 1333: 1332: 1290: 1289: 1172: 1096: 1081: 1080: 807:α-Ketoisocaproate 786: 771: 770: 624:Unknown/unsorted: 440: 306: 305: 234:Interactive image 146:CompTox Dashboard 27:Chemical compound 16:(Redirected from 1437: 1393: 1386: 1379: 1347: 1340: 1255: 1251: 1217: 1213: 1189: 1185: 1173:-Glucuronic acid 1170: 1133: 1129: 1110: 1106: 1100: 1090: 1021: 1017: 938: 934: 917:Sodium valproate 812:Acetoacetic acid 800: 796: 790: 780: 754: 750: 710:Prochlorperazine 454: 450: 444: 434: 419: 410: 403: 396: 387: 381: 380: 340: 302: 301: 294: 255:OC(CCC(C)(O)C)=O 236: 216: 201: 195: 189: 169: 168: 154: 152: 137: 117: 97: 42: 35: 33: 21: 1445: 1444: 1440: 1439: 1438: 1436: 1435: 1434: 1400: 1399: 1398: 1397: 1336: 1334: 1329: 1286: 1253: 1243: 1215: 1205: 1187: 1177: 1131: 1121: 1108: 1089: 1077: 1019: 1009: 1005:Salicyclic acid 936: 926: 798: 779: 767: 752: 749: 739: 675:azido-BnOPh-GHB 452: 433: 425: 414: 384: 342: 341: 337: 333: 297: 295: 292:(what is this?) 289: 284: 281: 276: 271: 270: 259: 256: 251: 250: 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829: 824: 819: 814: 809: 803: 801: 787: 773: 772: 769: 768: 766: 765: 757: 755: 747: 741: 740: 738: 737: 732: 727: 722: 717: 712: 707: 702: 697: 692: 687: 682: 677: 672: 667: 662: 657: 652: 647: 642: 637: 632: 620: 619: 614: 602: 601: 596: 584: 579: 574: 569: 564: 559: 554: 549: 547:Sodium oxybate 544: 539: 534: 529: 524: 519: 514: 509: 504: 499: 494: 489: 484: 479: 474: 469: 457: 455: 441: 427: 426: 415: 413: 412: 405: 398: 390: 383: 382: 355:(2): 675–679. 334: 332: 329: 304: 303: 286: 285: 283: 282: 279: 277: 274: 266: 265: 264: 261: 260: 258: 257: 254: 246: 245: 244: 241: 240: 238: 237: 229: 227: 219: 218: 212: 206: 205: 202: 196: 190: 185: 179: 178: 174: 173: 171: 170: 162:DTXSID50633867 157: 155: 142: 141: 139: 138: 130: 128: 122: 121: 119: 118: 110: 108: 102: 101: 99: 98: 90: 88: 82: 81: 79: 78: 75: 67: 66: 65: 62: 61: 57: 56: 53: 49: 48: 44: 43: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 1442: 1431: 1428: 1426: 1423: 1421: 1418: 1416: 1413: 1411: 1408: 1407: 1405: 1394: 1389: 1387: 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872:Niflumic acid 870: 868: 865: 863: 860: 858: 857:Hexanoic acid 855: 853: 850: 848: 845: 843: 840: 838: 835: 833: 830: 828: 825: 823: 820: 818: 815: 813: 810: 808: 805: 804: 802: 797: 791: 788: 784: 778: 774: 763: 759: 758: 756: 751: 742: 736: 733: 731: 728: 726: 723: 721: 718: 716: 713: 711: 708: 706: 703: 701: 700:Levosulpiride 698: 696: 693: 691: 688: 686: 683: 681: 678: 676: 673: 671: 668: 666: 665:4-Phenyl-THCA 663: 661: 658: 656: 655:4-Methyl-THCA 653: 651: 648: 646: 643: 641: 640:3-Methyl-THCA 638: 636: 633: 631: 628: 625: 622: 621: 618: 615: 613: 610: 607: 604: 603: 600: 597: 595: 592: 588: 585: 583: 580: 578: 575: 573: 570: 568: 565: 563: 560: 558: 555: 553: 550: 548: 545: 543: 540: 538: 535: 533: 530: 528: 525: 523: 520: 518: 515: 513: 510: 508: 505: 503: 500: 498: 495: 493: 490: 488: 485: 483: 480: 478: 475: 473: 470: 468: 465: 462: 459: 458: 456: 451: 445: 442: 438: 432: 428: 424: 421: 411: 406: 404: 399: 397: 392: 391: 388: 378: 374: 370: 366: 362: 358: 354: 350: 346: 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1073:Vigabatrin 1043:Evans blue 990:Probenecid 970:Ketoprofen 960:Fenoprofen 892:Probenecid 817:AR-C155858 720:Sultopride 627:Main site: 609:Main site: 464:Main site: 423:modulators 331:References 222:3D model ( 210:Molar mass 135:RBT229QVC5 106:ChemSpider 95:23327-19-7 86:CAS Number 69:IUPAC name 1272:Cyanamide 1117:Quercetin 1058:Nigericin 1028:β-Alanine 965:Ibuprofen 902:Quercetin 887:Phloretin 715:Sulpiride 680:BnOPh-GHB 599:Monastrol 461:Agonists: 325:GABAergic 1298:See also 1282:Prunetin 1239:Pyrazole 980:Naproxen 867:Luteolin 783:blockers 764:instead. 431:Receptor 420:receptor 377:86191608 369:12606613 299:(verify) 115:10466768 1229:Ethanol 1196:Cyanide 1053:Glycine 705:NCS-400 617:NCS-382 542:NCS-435 537:NCS-356 437:ligands 215:132.159 183:Formula 1087:Enzyme 735:UMB119 730:UMB109 725:UMB108 650:4-HPBA 527:HOCPCA 522:HOCHCA 467:1,4-BD 375:  367:  248:SMILES 1359:is a 1351:This 1128:GHBDH 1016:VIATT 933:SMCTs 630:2-HPA 587:UMB86 582:UMB73 577:UMB72 572:UMB68 567:UMB66 562:UMB58 507:GHBAL 472:3-HPA 373:S2CID 313:UMB68 268:InChI 224:JSmol 1361:stub 1353:drug 1250:ALDH 1048:GABA 877:NPPB 852:DIDS 847:DBDS 842:CHCA 795:MCTs 762:here 760:See 746:GABA 695:GTBL 449:GHBR 365:PMID 126:UNII 1212:ADH 1184:HOT 1105:SSR 950:BHB 832:BHB 690:DVL 685:DHV 557:THF 532:MAB 517:GVL 502:GHB 497:GCL 492:GBL 487:EAB 418:GHB 357:doi 353:305 317:GHB 151:EPA 1406:: 589:; 371:. 363:. 351:. 347:. 197:12 1392:e 1385:t 1378:v 1367:. 1171:D 1095:) 1091:( 785:) 781:( 748:B 439:) 435:( 409:e 402:t 395:v 379:. 359:: 311:( 226:) 203:3 200:O 194:H 191:6 188:C 153:) 149:( 20:)

Index

4-hydroxy-4-methylpentanoic acid

IUPAC name
CAS Number
23327-19-7
ChemSpider
10466768
UNII
RBT229QVC5
CompTox Dashboard
DTXSID50633867
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Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
(what is this?)
(verify)
GHB
GHB receptor
GABAergic
"A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand"
doi
10.1124/jpet.102.046797
PMID
12606613
S2CID
86191608

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