303:
42:
492:
659:, which activates the latter to ring cleavage. Carbon atoms from ribose in PRPP form the linear chain and part of the imidazole ring in histidine. The same is true for the biosynthesis of tryptophan, with the first step being N-alkylation of
150:
1051:
Silva, Carlos H. T. P.; Silva, Marcio; Iulek, Jorge; Thiemann, Otavio H. (2008). "Structural
Complexes of Human Adenine Phosphoribosyltransferase Reveal Novel Features of the APRT Catalytic Mechanism".
1557:
1174:
González-Segura, Lilian; Witte, John F.; McClard, Ronald W.; Hurley, Thomas D. (2007). "Ternary
Complex Formation and Induced Asymmetry in Orotate Phosphoribosyltransferase".
1550:
1656:
699:
1662:
1329:
553:
536:
1543:
352:
1674:
931:
Mehta, Angad P.; Abdelwahed, Sameh H.; Fenwick, Michael K.; Hazra, Amrita B.; Taga, Michiko E.; Zhang, Yang; Ealick, Steven E.; Begley, Tadhg P. (2015).
1644:
933:"Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B12 Biosynthesis"
664:
1490:
Cakmakli, Hasan F.; Torres, Rosa J.; Menendez, Araceli; Yalcin-Cakmakli, Gul; Porter, Christopher C.; Puig, Juan Garcia; Jinnah, H.A. (2019).
326:
InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1
1305:
836:
336:
InChI=1/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1
570:
1638:
619:
1474:
1098:
Finette, Barry A.; Kendall, Heather; Vacek, Pamela M. (2002). "Mutational spectral analysis at the HPRT locus in healthy children".
585:
519:
317:
602:
483:
862:"A "Radical Dance" in Thiamin Biosynthesis: Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase"
644:
28:
227:
1807:
595:
420:
260:
1632:
281:
1885:
1914:
1650:
715:
695:
1919:
1723:
221:
1135:"A new paradigm for biochemical energy coupling. Salmonella typhimurium nicotinate phosphoribosyltransferase"
1787:
1714:
1691:
725:
546:
529:
1875:
1852:
1797:
1569:
656:
629:
1812:
1770:
1344:
612:
563:
68:
54:
1409:
860:
Chatterjee, Abhishek; Hazra, Amrita B.; Abdelwahed, Sameh; Hilmey, David G.; Begley, Tadhg P. (2010).
982:"Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site"
910:
746:
1260:"Guanine and Xanthine Phosphoribosyltransfer Activities of Lactobacillus casei and Escherichia coli"
298:
1792:
1668:
1626:
720:
648:
116:
1614:
1597:
1390:
1323:
1077:
842:
479:
17:
41:
1741:
1577:
1521:
1470:
1447:
1382:
1311:
1301:
1240:
1191:
1156:
1115:
1069:
1030:
1011:
962:
891:
832:
801:
639:
498:
It plays a role in transferring phospho-ribose groups in several reactions, some of which are
1700:
1511:
1503:
1439:
1430:
Crawford, Irving P. (1989). "Evolution of a
Biosynthetic Pathway: The Tryptophan Paradigm".
1374:
1271:
1230:
1222:
1183:
1146:
1107:
1061:
1001:
993:
952:
944:
881:
873:
824:
791:
783:
660:
440:
375:
269:
684:
499:
190:
126:
1443:
302:
170:
1880:
1516:
1491:
1235:
1210:
1006:
981:
957:
932:
886:
861:
796:
771:
414:
1276:
1259:
1151:
1134:
1111:
1908:
1847:
1603:
1535:
846:
680:
675:
Increased levels of PRPP are characterized by the overproduction and accumulation of
451:
1394:
1081:
1746:
1065:
558:
1842:
828:
249:
1802:
447:
1566:
1507:
1378:
1226:
787:
702:(HGPRT) causes this accumulation, as PRPP is a substrate used by HGPRT during
575:
475:
455:
402:
181:
1315:
819:
Gupta, Rani; Gupta, Namita (2021). "Nucleotide
Biosynthesis and Regulation".
1751:
676:
652:
471:
1525:
1386:
1244:
1195:
1119:
1073:
1015:
966:
895:
877:
805:
491:
1451:
1295:
1160:
1756:
1211:"Dynamic dissociating homo-oligomers and the control of protein function"
948:
624:
467:
201:
980:
Li, Sheng; Lu, Yongcheng; Peng, Baozhen; Ding, Jianping (January 2007).
210:
1864:
1365:
Stepansky, A.; Leustek, T. (2006). "Histidine biosynthesis in plants".
997:
590:
541:
524:
236:
1187:
1831:
1100:
Mutation
Research/Fundamental and Molecular Mechanisms of Mutagenesis
703:
607:
444:
1300:. Judith G. Voet, Charlotte W. Pratt (Fifth ed.). Hoboken, NJ.
413:
Except where otherwise noted, data are given for materials in their
62:-Ribofuranose 1′-(trihydrogen diphosphate) 5′-(dihydrogen phosphate)
1258:
Krenitsky, Thomas A.; Neil, Shannon M.; Miller, Richard L. (1970).
161:
149:
139:
688:
1539:
1297:
Fundamentals of biochemistry : life at the molecular level
1465:
Elliott, Katherine; Fitzsimons, David W. (16 September 2009).
463:
459:
655:
biosynthesis pathway involves the reaction between PRPP and
478:
also contain fragments derived from PRPP. It is formed from
286:
1492:"Macrocytic anemia in Lesch–Nyhan disease and its variants"
911:"Pathway: 5-hydroxybenzimidazole biosynthesis (anaerobic)"
747:"Pathway: 5-aminoimidazole ribonucleotide biosynthesis I"
772:"Structural biology of the purine biosynthetic pathway"
458:
nucleotide formation. Hence it is a building block for
443:. It is a biochemical intermediate in the formation of
89:)-3,4-Dihydroxy-5-oxolan-2-yl trihydrogen diphosphate
1861:
1828:
1821:
1780:
1769:
1734:
1707:
1684:
1594:
1587:
1576:
821:
Fundamentals of
Bacterial Physiology and Metabolism
248:
1093:
1091:
700:hypoxanthine guanine phosphoribosyl transferase
125:
27:"PRPP" redirects here. Not to be confused with
1663:Phosphoribosylaminoimidazolesuccinocarboxamide
1054:Journal of Biomolecular Structure and Dynamics
554:hypoxanthine-guanine phosphoribosyltransferase
537:hypoxanthine-guanine phosphoribosyltransferase
1551:
8:
1657:5′-Phosphoribosyl-4-carboxy-5-aminoimidazole
1675:5-Formamidoimidazole-4-carboxamide ribotide
1469:. John Wiley & Sons. pp. 143–158.
770:Zhang, Y.; Morar, M.; Ealick, S.E. (2008).
1825:
1777:
1591:
1584:
1558:
1544:
1536:
1328:: CS1 maint: location missing publisher (
1209:Selwood, Trevor; Jaffe, Eileen K. (2012).
301:
189:
33:
1515:
1275:
1234:
1150:
1005:
956:
885:
795:
268:
937:Journal of the American Chemical Society
694:Increased levels of PRPP are present in
504:
1215:Archives of Biochemistry and Biophysics
866:Angewandte Chemie International Edition
765:
763:
737:
360:O=P(O1O((O)1O)COP(=O)(O)O)(O)OP(=O)(O)O
357:
322:
297:
226:
209:
1321:
665:anthranilate phosphoribosyltransferase
1289:
1287:
329:Key: PQGCEDQWHSBAJP-TXICZTDVSA-N
169:
7:
1645:5′-Phosphoribosylformylglycinamidine
1412:. MetaCyc Metabolic Pathway Database
1410:"Pathway: L-tryptophan biosynthesis"
1347:. MetaCyc Metabolic Pathway Database
1133:Vinitsky, A.; Grubmeyer, C. (1993).
1033:. MetaCyc Metabolic Pathway Database
1031:"5-phospho-α-D-ribose 1-diphosphate"
913:. MetaCyc Metabolic Pathway Database
776:Cellular and Molecular Life Sciences
749:. MetaCyc Metabolic Pathway Database
571:nicotinate phosphoribosyltransferase
1639:Phosphoribosyl-N-formylglycineamide
1444:10.1146/annurev.mi.43.100189.003031
1345:"Pathway: L-histidine biosynthesis"
339:Key: PQGCEDQWHSBAJP-TXICZTDVBW
239:
643:generation of purines, the enzyme
620:xanthine phosphoribosyltransferase
25:
586:orotate phosphoribosyltransferase
520:adenine phosphoribosyltransferase
1467:Purine and Pyrimidine Metabolism
603:uracil phosphoribosyltransferase
490:
484:ribose-phosphate diphosphokinase
40:
18:5-phosphoribosyl-1-pyrophosphate
1264:Journal of Biological Chemistry
1139:Journal of Biological Chemistry
417:(at 25 °C , 100 kPa).
1066:10.1080/07391102.2008.10507205
687:. It is one of the causes of
645:amidophosphoribosyltransferase
29:Pooled Retirement Pension Plan
1:
1432:Annual Review of Microbiology
1277:10.1016/S0021-9258(18)63113-8
1152:10.1016/S0021-9258(19)74485-8
1112:10.1016/S0027-5107(02)00119-7
35:Phosphoribosyl pyrophosphate
1621:Phosphoribosyl pyrophosphate
829:10.1007/978-981-16-0723-3_19
433:Phosphoribosyl pyrophosphate
228:Phosphoribosyl+pyrophosphate
1633:Glycineamide ribonucleotide
1408:C.A. Fulcher (2010-02-12).
1936:
1808:Orotidine 5'-monophosphate
407:390.07 g/mol
26:
1651:5-Aminoimidazole ribotide
1508:10.1038/s41436-018-0053-1
1379:10.1007/s00726-005-0247-0
1227:10.1016/j.abb.2011.11.020
788:10.1007/s00018-008-8295-8
716:5-Aminoimidazole ribotide
647:acts upon PRPP to create
411:
368:
348:
313:
109:
95:
67:
53:
48:
39:
1724:Xanthosine monophosphate
663:catalysed by the enzyme
1886:β-Ureidoisobutyric acid
1788:Carbamoyl aspartic acid
1570:metabolic intermediates
1343:R. Caspi (2008-10-10).
1029:R. Caspi (2022-02-15).
909:R. Caspi (2019-09-23).
745:R. Caspi (2009-01-13).
726:Pyrimidine biosynthesis
698:. Decreased levels of
452:inosine-5-monophosphate
1876:3-Aminoisobutyric acid
1853:3-Ureidopropionic acid
1798:4,5-Dihydroorotic acid
878:10.1002/anie.201003419
1813:Uridine monophosphate
1294:Voet, Donald (2016).
474:, and the amino acid
102:-ribose 1-diphosphate
69:Systematic IUPAC name
1496:Genetics in Medicine
949:10.1021/jacs.5b03576
823:. pp. 525–554.
696:Lesch–Nyhan Syndrome
580:nicotinate riboside
482:(R5P) by the enzyme
1793:Carbamoyl phosphate
1669:AICA ribonucleotide
1627:Phosphoribosylamine
1182:(49): 14075–14086.
1145:(34): 26004–26010.
986:Biochemical Journal
943:(33): 10444–10447.
721:Purine biosynthesis
649:phosphoribosylamine
36:
1615:Ribose 5-phosphate
998:10.1042/BJ20061066
480:ribose 5-phosphate
421:Infobox references
34:
1902:
1901:
1898:
1897:
1894:
1893:
1765:
1764:
1742:5-Hydroxyisourate
1730:
1729:
1307:978-1-118-91840-1
1270:(10): 2605–2611.
1188:10.1021/bi701023z
872:(46): 8653–8656.
838:978-981-16-0722-6
782:(23): 3699–3724.
635:
634:
441:pentose phosphate
429:Chemical compound
427:
426:
282:CompTox Dashboard
151:Interactive image
101:
61:
16:(Redirected from
1927:
1915:Organophosphates
1868:
1835:
1826:
1778:
1718:
1701:Adenylosuccinate
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799:
767:
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757:
755:
754:
742:
661:anthranilic acid
505:
500:salvage pathways
494:
454:, as well as in
376:Chemical formula
306:
305:
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99:
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1920:Monosaccharides
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685:hyperuricosuria
673:
466:. The vitamins
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1881:Dihydrothymine
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1540:
1532:
1531:
1502:(2): 353–360.
1482:
1475:
1457:
1422:
1400:
1373:(2): 127–142.
1357:
1335:
1306:
1283:
1250:
1221:(2): 131–143.
1201:
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1125:
1106:(1–2): 27–41.
1087:
1060:(6): 589–597.
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1021:
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811:
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671:Increased PRPP
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415:standard state
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299:DTXSID40895038
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1848:Dihydrouracil
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1476:9780470717981
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1747:Hypoxanthine
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1176:Biochemistry
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559:hypoxanthine
497:
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110:Identifiers
98:5-phospho-α-
96:Other names
86:
82:
78:
74:
1803:Orotic acid
1438:: 567–600.
1367:Amino Acids
679:leading to
448:nucleotides
369:Properties
171:CHEBI:17111
1909:Categories
1822:catabolism
1773:metabolism
1771:pyrimidine
1735:catabolism
1580:metabolism
1567:Nucleotide
1416:2022-02-17
1351:2022-02-17
1037:2022-02-15
917:2022-02-10
753:2022-02-02
732:References
576:nicotinate
476:tryptophan
456:pyrimidine
403:Molar mass
270:W5555R4ERG
182:ChemSpider
138:3D model (
117:CAS Number
55:IUPAC name
1843:β-Alanine
1781:anabolism
1752:Uric acid
1588:anabolism
1324:cite book
1316:910538334
847:234897784
706:salvage.
677:uric acid
653:histidine
472:cobalamin
127:7540-64-9
1757:Xanthine
1677:(FAICAR)
1665:(SAICAR)
1526:29875418
1395:23733445
1387:16547652
1245:22182754
1196:18020427
1120:12175903
1082:40788077
1074:18399692
1016:16939420
967:26237670
896:20886485
806:18712276
710:See also
625:xanthine
514:Product
511:Reactant
468:thiamine
202:DrugBank
1865:thymine
1671:(AICAR)
1517:6281870
1452:2679363
1236:3298769
1161:7503993
1007:1698673
958:4753784
887:3147014
797:2596281
640:de novo
591:orotate
542:guanine
525:adenine
439:) is a
397:
237:PubChem
211:DB01632
1832:uracil
1659:(CAIR)
1647:(FGAM)
1641:(FGAR)
1623:(PRPP)
1578:purine
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704:purine
651:. The
608:uracil
508:Enzyme
445:purine
353:SMILES
49:Names
1653:(AIR)
1635:(GAR)
1629:(PRA)
1617:(R5P)
1391:S2CID
1078:S2CID
843:S2CID
318:InChI
162:ChEBI
140:JSmol
1522:PMID
1471:ISBN
1448:PMID
1383:PMID
1330:link
1312:OCLC
1302:ISBN
1241:PMID
1192:PMID
1157:PMID
1116:PMID
1070:PMID
1012:PMID
963:PMID
892:PMID
833:ISBN
802:PMID
689:gout
683:and
470:and
462:and
450:via
437:PRPP
261:UNII
250:7339
222:MeSH
191:7062
104:PRPP
1715:GMP
1710:IMP
1692:AMP
1687:IMP
1604:IMP
1598:R5P
1512:PMC
1504:doi
1440:doi
1375:doi
1272:doi
1268:245
1231:PMC
1223:doi
1219:519
1184:doi
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1108:doi
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1062:doi
1002:PMC
994:doi
990:401
953:PMC
945:doi
941:137
882:PMC
874:doi
825:doi
792:PMC
784:doi
657:ATP
637:In
630:XMP
613:UMP
596:OMP
564:IMP
547:GMP
530:AMP
502::
464:RNA
460:DNA
287:EPA
240:CID
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