142:
40:
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Albumin comprises three homologous domains that assemble to form a heart-shaped protein. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA,
1312:
Schoentgen F, Metz-Boutigue MH, Jollès J, Constans J, Jollès P (June 1986). "Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein".
1546:
Nishio H, Heiskanen M, Palotie A, Bélanger L, Dugaiczyk A (May 1996). "Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription".
1047:
legislation. Dip sticks, similar to common pregnancy tests, have been developed to detect the presence of bear albumin in traditional medicine products, indicating that bear bile had been used in their creation.
1261:
Haefliger DN, Moskaitis JE, Schoenberg DR, Wahli W (October 1989). "Amphibian albumins as members of the albumin, alpha-fetoprotein, vitamin D-binding protein multigene family".
2384:
402:
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The 3D structure of human serum albumin has been determined by X-ray crystallography to a resolution of 2.5 ångströms (250 pm). Albumin is a 65–70
1916:
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which exhibit similar chemistry. Structurally, the serum albumins are similar, each domain containing five or six internal disulfide bonds.
886:
is the main protein of human blood plasma. It makes up around 50% of human plasma proteins. It binds water, cations (such as Ca, Na and K),
951:. The Vitamin-D binding proteins occupy families 1–3. The other albumins are mixed among each other in families 4–6. ECM1 is in family 6.
243:
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123:
67:
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Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K (June 1999). "Crystal structure of human serum albumin at 2.5 A resolution".
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A few other proteins are also sometimes called albumins. They are not in the same family as vertebrate albumins:
959:
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A number of blood transport proteins are evolutionarily related in the albumin family, including serum albumin,
1969:
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1497:"Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin"
185:
159:
105:
53:
25:
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331:
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1350:"Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family"
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363:
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Mihara E, Hirai H, Yamamoto H, Tamura-Kawakami K, Matano M, Kikuchi A, et al. (February 2016).
894:, thyroxine (T4) and pharmaceuticals (including barbiturates). Its main function is to regulate the
174:
91:
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1993:
1983:
1973:
1704:
provides an overview of all the structure information available in the PDB for Human Serum albumin.
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883:
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Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, et al. (July 1994).
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This article is about the class of proteins. For the substance sometimes called albumen, see
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Farrugia A (January 2010). "Albumin usage in clinical medicine: tradition or therapeutic?".
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1396:"Genome-Wide Identification and Comparative Analysis of Albumin Family in Vertebrates"
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Peppin L, McEwing R, Webster S, Rogers A, Nicholls D, Ogden R (September 2008).
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Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
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is a fetal plasma protein that binds various cations, fatty acids and bilirubin.
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In addition to their medical use, serum albumins are valued in biotechnology.
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804:, moderately soluble in concentrated salt solutions, and experience heat
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binds to vitamin D and its metabolites, as well as to fatty acids.
20:. For the specific albumins found in vertebrate bloodstreams, see
947:
Albumins found in animals can be divided into six subfamilies by
1582:
Shewry PR, Pandya MJ (1999). "The 2S Albumin
Storage Proteins".
1141:
1003:
875:
Albumins in general are transport proteins that bind to various
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is a less canonical albumin. It regulates bone mineralization.
135:
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33:
1707:
1014:". These are named for their egg-like coagulation property.
999:, although serum albumin also comprises a small part of it.
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1083:
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1065:
1208:"Atomic structure and chemistry of human serum albumin"
1140:
This article incorporates text from the public domain
800:. All of the proteins of the albumin family are water-
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in a less strict sense can mean other proteins that
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958:is usually used, although versions from humans and
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166:. Unsourced material may be challenged and removed.
935:The four canonical human albumins are arranged on
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995:, is a protein fraction of milk. It is mainly
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1199:
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101:Improved diagram in structure section needed.
8:
879:and carry them around. Human types include:
820:. Substances containing albumins are called
68:Learn how and when to remove these messages
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1950:
1941:
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2385:disorders of globin and globulin proteins
1684:at the U.S. National Library of Medicine
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1114:(human serum albumin purification method)
244:Learn how and when to remove this message
226:Learn how and when to remove this message
124:Learn how and when to remove this message
962:are also used to reduce animal cruelty.
855:
1155:
1661:"Pliny the Elder, The Natural History"
255:
1043:contain wild bear bile, banned under
7:
164:adding citations to reliable sources
1354:The Journal of Biological Chemistry
796:, the most common of which are the
1400:Evolutionary Bioinformatics Online
939:region 4q13.3 in a tandem manner.
14:
1590:. Springer Netherlands. pp.
808:. Albumins are commonly found in
49:This article has multiple issues.
1479:"Product Information data sheet"
1102:"(egg) white; dried egg white".
1058:
981:in egg white (albumen). It is a
140:
79:
38:
1758:Post-translational modification
839:. This family is only found in
151:needs additional citations for
57:or discuss these issues on the
2364:Extracellular matrix protein 1
1263:Journal of Molecular Evolution
1206:He XM, Carter DC (July 1992).
929:Extracellular matrix protein 1
921:. It seems to carry lipidated
853:under certain conditions. See
1:
1367:10.1016/S0021-9258(17)32429-8
1041:traditional Chinese medicines
374:Available protein structures:
2095:Sex hormone-binding globulin
1665:Historia Naturalis 28, 6, 18
1600:10.1007/978-94-011-4431-5_24
1549:Journal of Molecular Biology
1445:Transfusion Medicine Reviews
1394:Li S, Cao Y, Geng F (2017).
1327:10.1016/0167-4838(86)90173-1
1632:Endangered Species Research
270:Structure of serum albumin.
99:. The specific problem is:
31:Family of globular proteins
2428:
1799:Protein structural domains
1697:Albumin binding prediction
1457:10.1016/j.tmrv.2009.09.005
1139:
856:§ Other albumin types
95:to meet Knowledge (XXG)'s
15:
2376:
2359:Vitamin D-binding protein
960:genetically-modified rice
912:Vitamin D-binding protein
833:vitamin D-binding protein
369:
263:
1970:Alpha 1-antichymotrypsin
1686:Medical Subject Headings
1412:10.1177/1176934317716089
1180:10.1093/protein/12.6.439
917:Not much is known about
867:and plant "2S albumin".
26:Albumin (disambiguation)
2253:7S seed storage protein
2030:Retinol binding protein
1561:10.1006/jmbi.1996.0306
1056:Albumin is pronounced
812:and differ from other
24:. For other uses, see
2412:Seed storage proteins
2056:alpha-2-Macroglobulin
1862:Photoreceptor protein
925:and Vitamin E around.
816:in that they are not
2313:Bovine serum albumin
2129:Beta-2 microglobulin
1753:Protein biosynthesis
1406:: 1176934317716089.
1123:Bovine serum albumin
956:Bovine serum albumin
259:Serum albumin family
160:improve this article
106:improve this article
2308:Human serum albumin
2248:11S globulin family
1994:Heparin cofactor II
1984:Alpha 2-antiplasmin
1974:Alpha 1-antitrypsin
1692:The Albumin website
1514:10.7554/eLife.11621
1275:1989JMolE..29..344H
1224:1992Natur.358..209H
1168:Protein Engineering
1128:Human serum albumin
1039:Worldwide, certain
966:Other albumin types
884:Human serum albumin
2334:C-reactive protein
2226:Beta-lactoglobulin
1283:10.1007/BF02103621
997:Beta-lactoglobulin
902:of albumin is 4.7.
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2343:Alpha-lactalbumin
2243:Alpha-lactalbumin
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2186:Fetal fibronectin
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1926:Globular proteins
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1794:Protein structure
1768:Protein targeting
1609:978-94-011-4431-5
906:Alpha-fetoprotein
900:isoelectric point
829:alpha-fetoprotein
794:globular proteins
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88:This article may
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2006:carrier proteins
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1872:Phycobiliprotein
1830:Globular protein
1825:Membrane protein
1820:List of proteins
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1484:. Sigma Aldrich.
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1360:(27): 18149–54.
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1778:Protein methods
1763:Protein folding
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2201:Transcobalamin
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2158:Gamma globulin
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2075:Beta globulins
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1676:External links
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943:Classification
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898:of blood. The
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798:serum albumins
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2300:Serum albumin
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2269:
2266:
2264:
2260:
2254:
2251:
2249:
2246:
2244:
2241:
2239:
2238:Thyroglobulin
2236:
2232:
2229:
2228:
2227:
2224:
2223:
2221:
2217:
2207:
2204:
2202:
2199:
2197:
2196:Microglobulin
2193:
2192:Macroglobulin
2190:
2187:
2183:
2180:
2179:
2177:
2173:
2167:
2164:
2163:
2161:
2159:
2155:
2145:
2142:
2140:
2137:
2135:
2132:
2130:
2127:
2125:
2122:
2120:
2117:
2116:
2114:
2108:
2101:
2098:
2096:
2093:
2092:
2090:
2086:
2081:
2078:
2076:
2072:
2061:
2057:
2053:
2050:
2046:
2045:
2043:
2037:
2031:
2028:
2025:
2024:Ceruloplasmin
2021:
2018:
2014:
2013:
2011:
2007:
2002:
1995:
1991:
1988:
1985:
1981:
1978:
1975:
1971:
1967:
1964:
1963:
1961:
1957:
1952:
1949:
1947:
1943:
1940:
1938:
1935:
1931:
1927:
1920:
1915:
1913:
1908:
1906:
1901:
1900:
1897:
1883:
1880:
1878:
1875:
1873:
1870:
1869:
1868:
1865:
1863:
1860:
1858:
1857:Chromoprotein
1855:
1853:
1850:
1846:
1843:
1841:
1838:
1836:
1833:
1832:
1831:
1828:
1826:
1823:
1821:
1818:
1817:
1815:
1811:
1805:
1802:
1800:
1797:
1795:
1792:
1791:
1789:
1785:
1779:
1776:
1774:
1771:
1769:
1766:
1764:
1761:
1759:
1756:
1754:
1751:
1750:
1748:
1744:
1740:
1733:
1728:
1726:
1721:
1719:
1714:
1713:
1710:
1703:
1700:
1698:
1695:
1693:
1690:
1687:
1683:
1680:
1679:
1675:
1666:
1662:
1655:
1652:
1646:
1641:
1638:(3): 263–70.
1637:
1633:
1626:
1619:
1616:
1611:
1605:
1601:
1597:
1593:
1588:
1587:
1586:Seed Proteins
1578:
1575:
1570:
1566:
1562:
1558:
1554:
1550:
1542:
1539:
1534:
1530:
1525:
1520:
1515:
1510:
1506:
1502:
1498:
1491:
1488:
1480:
1474:
1471:
1466:
1462:
1458:
1454:
1450:
1446:
1439:
1436:
1431:
1427:
1422:
1417:
1413:
1409:
1405:
1401:
1397:
1390:
1388:
1386:
1382:
1377:
1373:
1368:
1363:
1359:
1355:
1351:
1344:
1341:
1336:
1332:
1328:
1324:
1321:(2): 189–98.
1320:
1316:
1308:
1305:
1300:
1296:
1292:
1288:
1284:
1280:
1276:
1272:
1269:(4): 344–54.
1268:
1264:
1257:
1254:
1249:
1245:
1241:
1237:
1233:
1229:
1225:
1221:
1217:
1213:
1209:
1202:
1200:
1198:
1194:
1189:
1185:
1181:
1177:
1174:(6): 439–46.
1173:
1169:
1162:
1160:
1156:
1151:
1147:
1143:
1135:
1129:
1126:
1124:
1121:
1120:
1119:
1118:Serum albumin
1116:
1113:
1110:
1109:
1105:
1103:
1101:
1097:
1091:
1051:
1049:
1046:
1042:
1035:Forensic uses
1034:
1032:
1028:
1026:
1018:
1013:
1009:
1005:
1001:
998:
994:
990:
987:
984:
980:
976:
973:
972:
971:
965:
963:
961:
957:
952:
950:
942:
940:
938:
930:
927:
924:
920:
916:
913:
910:
907:
904:
901:
897:
893:
889:
885:
882:
881:
880:
878:
870:
868:
866:
862:
858:
857:
852:
848:
844:
842:
838:
834:
830:
825:
823:
819:
815:
811:
807:
803:
799:
795:
791:
787:
773:
767:
761:
755:
749:
743:
737:
731:
725:
719:
713:
707:
701:
695:
689:
683:
677:
671:
665:
659:
653:
647:
641:
635:
629:
623:
617:
611:
605:
599:
593:
587:
581:
575:
569:
563:
557:
551:
545:
539:
533:
527:
521:
515:
509:
503:
497:
491:
485:
479:
473:
467:
461:
455:
449:
443:
437:
433:
431:
427:
424:
421:
419:
415:
412:
408:
404:
401:
399:
395:
391:
387:
384:
381:
377:
372:
368:
365:
361:
357:
354:
352:
348:
345:
342:
340:
336:
333:
330:
328:
324:
321:
318:
316:
312:
309:
306:
303:
299:
296:
293:
291:
287:
284:Serum_albumin
283:
279:
274:
267:
262:
257:
248:
245:
230:
227:
219:
208:
205:
201:
198:
194:
191:
187:
184:
180:
177: –
176:
172:
171:Find sources:
165:
161:
155:
154:
149:This article
147:
143:
138:
137:
128:
125:
117:
114:November 2016
107:
102:
98:
94:
93:
86:
77:
76:
71:
69:
62:
61:
56:
55:
50:
45:
36:
35:
27:
23:
22:serum albumin
19:
2381:
2262:
1990:Antithrombin
1844:
1664:
1654:
1635:
1631:
1618:
1585:
1577:
1555:(1): 113–9.
1552:
1548:
1541:
1504:
1500:
1490:
1473:
1451:(1): 53–63.
1448:
1444:
1438:
1403:
1399:
1357:
1353:
1343:
1318:
1314:
1307:
1266:
1262:
1256:
1215:
1211:
1171:
1167:
1112:Cohn process
1099:
1055:
1038:
1029:
1022:
1006:, including
993:whey protein
969:
953:
946:
937:chromosome 4
934:
923:Wnt proteins
890:, hormones,
874:
854:
846:
845:
826:
821:
818:glycosylated
810:blood plasma
806:denaturation
785:
784:
240:
222:
213:
203:
196:
189:
182:
170:
158:Please help
153:verification
150:
120:
111:
104:Please help
100:
89:
65:
58:
52:
51:Please help
48:
2349:Parvalbumin
2339:Lactalbumin
2231:Lactoferrin
2182:Fibronectin
2139:Plasminogen
2119:Angiostatin
2100:Transferrin
2060:Haptoglobin
2049:Orosomucoid
2017:Transcortin
1877:Phytochrome
1867:Biliprotein
1659:Bostock J.
1052:Terminology
1012:2S albumins
1002:Some plant
989:Lactalbumin
888:fatty acids
861:lactalbumin
841:vertebrates
822:albuminoids
276:Identifiers
108:if you can.
2401:Categories
2318:Prealbumin
2280:Conalbumin
1804:Proteasome
1787:Structures
1136:References
1010:, encode "
386:structures
216:March 2009
186:newspapers
54:improve it
2285:Ovalbumin
2272:Egg white
2144:Properdin
2124:Hemopexin
2054:alpha-2 (
2047:alpha-1 (
2022:alpha-2 (
2015:alpha-1 (
1937:globulins
1882:Lipocalin
1746:Processes
1150:IPR014760
1027:protein.
1019:Structure
975:Ovalbumin
949:phylogeny
892:bilirubin
865:ovalbumin
851:coagulate
769:,
763:,
757:,
751:,
745:,
739:,
733:,
727:,
721:,
715:,
709:,
703:,
697:,
691:,
685:,
679:,
673:,
667:,
661:,
655:,
649:,
643:,
637:,
631:,
625:,
619:,
613:,
607:,
601:,
595:,
589:,
583:,
577:,
571:,
565:,
559:,
553:,
547:,
541:,
535:,
529:,
523:,
517:,
511:,
505:,
499:,
493:,
487:,
481:,
475:,
469:,
463:,
457:,
451:,
445:,
439:,
320:IPR014760
175:"Albumin"
60:talk page
18:egg white
2382:see also
2263:Albumins
2134:Factor H
1835:Globulin
1773:Proteome
1739:Proteins
1682:Albumins
1533:26902720
1465:19962575
1430:28680266
1188:10388840
1146:InterPro
1106:See also
871:Function
847:Albumins
403:RCSB PDB
315:InterPro
90:require
2206:Edestin
1980:alpha-2
1966:alpha-1
1956:serpins
1845:Albumin
1840:Edestin
1702:PDBe-KB
1569:8648639
1524:4775226
1421:5480655
1376:7517938
1335:2423133
1299:1456034
1291:2481749
1271:Bibcode
1248:4353741
1240:1630489
1220:Bibcode
1100:albumen
877:ligands
802:soluble
786:Albumin
775:
344:PS51438
339:PROSITE
332:SM00103
295:PF00273
200:scholar
92:cleanup
2290:Avidin
2184:(fFN:
2111:other:
2040:other:
1688:(MeSH)
1606:
1594:–586.
1567:
1531:
1521:
1463:
1428:
1418:
1374:
1333:
1297:
1289:
1246:
1238:
1212:Nature
1186:
983:serpin
919:afamin
837:afamin
790:family
418:PDBsum
392:
382:
364:SUPFAM
308:CL0282
281:Symbol
202:
195:
188:
181:
173:
2354:Ricin
2327:Other
2175:Other
1934:Serum
1813:Types
1628:(PDF)
1501:eLife
1482:(PDF)
1295:S2CID
1244:S2CID
1096:Latin
1045:CITES
1004:seeds
991:, or
977:is a
788:is a
360:SCOPe
351:SCOP2
327:SMART
207:JSTOR
193:books
1604:ISBN
1565:PMID
1529:PMID
1461:PMID
1426:PMID
1372:PMID
1331:PMID
1287:PMID
1236:PMID
1184:PMID
1144:and
1142:Pfam
1008:hemp
859:for
835:and
772:3b9m
766:3b9l
760:2vuf
754:2vue
748:2vdb
742:2i30
736:2i2z
730:2bxq
724:2bxp
718:2bxo
712:2bxn
706:2bxm
700:2bxl
694:2bxk
688:2bxi
682:2bxh
676:2bxg
670:2bxf
664:2bxe
658:2bxd
652:2bxc
646:2bxb
640:2bxa
634:2bx8
628:1ysx
622:1uor
616:1tf0
610:1o9x
604:1n5u
598:1ma9
592:1lot
586:1kxp
580:1kw2
574:1j7e
568:1j78
562:1hk5
556:1hk4
550:1hk3
544:1hk2
538:1hk1
532:1ha2
526:1h9z
520:1gnj
514:1gni
508:1e7i
502:1e7h
496:1e7g
490:1e7f
484:1e7e
478:1e7c
472:1e7b
466:1e7a
460:1e78
454:1bm0
448:1bke
442:1bj5
436:1ao6
411:PDBj
407:PDBe
390:ECOD
380:Pfam
356:1ao6
304:clan
302:Pfam
290:Pfam
179:news
1640:doi
1596:doi
1592:563
1557:doi
1553:259
1519:PMC
1509:doi
1453:doi
1416:PMC
1408:doi
1362:doi
1358:269
1323:doi
1319:871
1279:doi
1228:doi
1216:358
1176:doi
1025:kDa
792:of
430:PDB
398:PDB
162:by
2403::
2058:,
1972:,
1663:.
1634:.
1630:.
1602:.
1563:.
1551:.
1527:.
1517:.
1507:.
1503:.
1499:.
1459:.
1449:24
1447:.
1424:.
1414:.
1404:13
1402:.
1398:.
1384:^
1370:.
1356:.
1352:.
1329:.
1317:.
1293:.
1285:.
1277:.
1267:29
1265:.
1242:.
1234:.
1226:.
1214:.
1210:.
1196:^
1182:.
1172:12
1170:.
1158:^
1148::
1098::
863:,
843:.
831:,
824:.
409:;
405:;
388:/
362:/
358:/
63:.
2345:)
2341:(
2194:/
2188:)
2087::
2062:)
2051:)
2026:)
2019:)
2008::
1996:)
1992:(
1986:)
1982:(
1976:)
1968:(
1958::
1918:e
1911:t
1904:v
1731:e
1724:t
1717:v
1667:.
1648:.
1642::
1636:9
1612:.
1598::
1571:.
1559::
1535:.
1511::
1505:5
1467:.
1455::
1432:.
1410::
1378:.
1364::
1337:.
1325::
1301:.
1281::
1273::
1250:.
1230::
1222::
1190:.
1178::
1090:/
1087:n
1084:ɪ
1081:m
1078:ʊ
1075:j
1072:b
1069:l
1066:æ
1063:ˈ
1060:/
985:.
247:)
241:(
229:)
223:(
218:)
214:(
204:·
197:·
190:·
183:·
156:.
127:)
121:(
116:)
112:(
70:)
66:(
28:.
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