148:. There are multiple classes of cadherin molecules, each designated with a prefix for tissues with which it associates. Classical cadherins maintain the tone of tissues by forming a homodimer in cis while desmosomal cadherins are heterodimeric. The intracellular portion of classical cadherins interacts with a complex of proteins that allows connection to the actin cytoskeleton. Although classical cadherins take a role in cell layer formation and structure formation, desmosomal cadherins focus on resisting cell damage. Desmosomal cadherins maintain the function of desmosomes that is to overturn the mechanical stress of the tissues. Similar to classical cadherins, desmosomal cadherins have a single transmembrane domain, five EC repeats, and an intracellular domain. There are two types of desmosomal cadherins: desmogleins and desmocollins. These contain an intracellular anchor and cadherin like sequence (ICS). The adaptor proteins that associate with desmosomal cadherins are plakoglobin (related to
371:, especially in sorting out of the precardiac mesoderm. N-cadherins are robustly expressed in precardiac mesoderm, but they do not take a role in cardiac linage. An embryo with N-cadherin mutation still forms the primitive heart tube; however, N-cadherin deficient mice will have difficulties in maintaining the cardiomyocytes development. The myocytes of these mice will end up with dissociated myocytes surrounding the endocardial cell layer when they cannot preserve the cell adhesion due to the heart starting to pump. As a result, the cardiac outflow tract will be blocked causing cardiac swelling. The expression of different types of cadherins in the cells varies dependent upon the specific differentiation and specification of an organism during development. Cadherins play a vital role in the migration of cells through the
375:, which requires cadherins to form adherents junctions with neighboring cells. In neural crest cells, which are transient cells that arise in the developing organism during gastrulation and function in the patterning of the vertebrate body plan, the cadherins are necessary to allow migration of cells to form tissues or organs. In addition, cadherins that are responsible in the epithelial–mesenchymal transition event in early development have also been shown to be critical in the reprogramming of specified adult cells into a pluripotent state, forming
22:
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316:-catenin is engaged by p120-catenin complex, where vinculin is recruited to take a role in indirect association with actin cytoskeleton. However, cadherin-catenin complex can also bind directly to the actin without the help of vinculin. Moreover, the strength of cadherin adhesion can increase by dephosphorylation of p120 catenin and the binding of
405:
form bridges. The loss of the cell adhesion molecules, E cadherins, is causally involved in the formation of epithelial types of cancers such as carcinomas. The changes in any types of cadherin expression may not only control tumor cell adhesion but also may affect signal transduction leading to the cancer cells growing uncontrollably.
638:
There are said to be over 100 different types of cadherins found in vertebrates, which can be classified into four groups: classical, desmosomal, protocadherins, and unconventional. These large amount of diversities are accomplished by having multiple cadherin encoding genes combined with alternative
430:
This family of glycoproteins is responsible for calcium-dependent mechanism of intracellular adhesion. E-cadherins are crucial in embryogenesis during several processes, including gastrulation, neurulation, and organogenesis. Furthermore, suppression of E-cadherins impairs intracellular adhesion. The
362:
forms in an embryo, the tissues residing near the cranial neural folds have decreased N-cadherin expression. Conversely, the expression of the N-cadherins remains unchanged in other regions of the neural tube that is located on the anterior-posterior axis of the vertebrate. N-cadherins have different
417:
such as the cadherin glycoproteins that normally function as the glue and holds cells together act as important mediators of cell to cell interactions. E-cadherins, on the surface of all epithelial cells, are linked to the actin cytoskeleton through interactions with catenins in the cytoplasm. Thus,
183:
tend to cluster with other N-cadherin-expressing cells. However, mixing speed in cell culture experiments can effect the extent of homotypic specificity. In addition, several groups have observed heterotypic binding affinity (i.e., binding of different types of cadherin together) in various assays.
25:
Principal interactions of structural proteins at cadherin-based adherens junction. Actin filaments are linked to α-actinin and to the membrane through vinculin. The head domain of vinculin is associated with E-cadherin via α-, β-, and γ-catenins. The tail domain of vinculin binds to membrane lipids
404:
It has been discovered that cadherins and other additional factors are correlated to the formation and growth of some cancers and how a tumor continues to grow. The E-cadherins, known as the epithelial cadherins, are on the surface of one cell and can bind with those of the same kind on another to
391:
The E-cadherin–catenin complex plays a key role in cellular adhesion; loss of this function has been associated with increased invasiveness and metastasis of tumors. The suppression of E-cadherin expression is regarded as one of the main molecular events responsible for dysfunction in cell-cell
200:
Cadherins are synthesized as polypeptides and undergo many post-translational modifications to become the proteins which mediate cell-cell adhesion and recognition. These polypeptides are approximately 720–750 amino acids long. Each cadherin has a small C-terminal cytoplasmic component, a
418:
anchored to the cytoskeleton, E-cadherins on the surface of one cell can bind with those on another to form bridges. In epithelial cell cancers, disrupted cell-cell adhesion that might lead to metastases can result from abnormalities in the expression of E-cadherin or its associated
349:
Cadherins behave as both receptors and ligands for other molecules. During development, their behavior assists at properly positioning cells: they are responsible for the separation of the different tissue layers and for cellular migration. In the very early stages of development,
168:-catenin), plakophilins (p120 catenin subfamily), and desmoplakins. The major function of desmoplakins is to bind to intermediate filament by interacting with plakoglobin, which attach to the ICS of desmogleins, desmocollins and plakophilins. Atypical cadherins, such as
363:
functions that maintain the cell structure, cell-cell adhesion, internal adhesions. They participate greatly in keeping the ability of the structured heart due to pumping and release blood. Because of the contribution of N-cadherins adhering strongly between the
408:
In epithelial cell cancers, disrupted cell to cell adhesion might lead to the development of secondary malignant growths; they are distant from the primary site of cancer and can result from the abnormalities in the expression of E-cadherins or its associated
395:
Additionally, the overexpression of type 5, 6, and 17 cadherins alone or in combination can lead to cancer metastasis, and ongoing research aims to block their ability to function as ligands for integral membrane proteins.
172:, retain the extracellular repeats and binding activities of the other cadherins, but may otherwise differ significantly in structure, and are typically involved in transmitting developmental signals rather than adhesion.
382:
After development, cadherins play a role in maintaining cell and tissue structure, and in cellular movement. Regulation of cadherin expression can occur through promoter methylation among other epigenetic mechanisms.
184:
One current model proposes that cells distinguish cadherin subtypes based on kinetic specificity rather than thermodynamic specificity, as different types of cadherin homotypic bonds have different lifetimes.
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adhesion, which can lead to local invasion and ultimately tumor development. Because E-cadherins play an important role in tumor suppression, they are also referred to as the "suppressors of invasion".
228:-dimers. Once the cell-cell adhesion between cadherins present in the cell membranes of two different cells has formed, adherens junctions can then be made when protein complexes, usually composed of
354:(epithelial cadherin) are most greatly expressed. Many cadherins are specified for specific functions in the cell, and they are differentially expressed in a developing embryo. For example, during
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Daw S, Law S (February 2021). "The functional interplay of transcription factors and cell adhesion molecules in experimental myelodysplasia including hematopoietic stem progenitor compartment".
3006:
Chmelarova M, Baranova I, Ruszova E, Laco J, Hrochova K, Dvorakova E, et al. (October 2019). "Importance of
Cadherins Methylation in Ovarian Cancer: a Next Generation Sequencing Approach".
2680:
Georgolios A, Batistatou A, Manolopoulos L, Charalabopoulos K (March 2006). "Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC)".
2344:
Grigorian IY, Linkova NS, Polyakova VO, Paltseva EM, Kozlov KL (January 2016). "Signaling molecules of the endometrium: Gerontological and general pathological aspects".
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594:
367:, the heart can overcome the fracture, deformation, and fatigue that can result from the blood pressure. N-cadherin takes part in the development of the heart during
334:
314:
250:
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Volk T, Cohen O, Geiger B (September 1987). "Formation of heterotypic adherens-type junctions between L-CAM-containing liver cells and A-CAM-containing lens cells".
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166:
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213: dimer conformations: strand-swap dimers (S-dimers) and X-dimers. To date, over 100 types of cadherins in humans have been identified and sequenced.
201:
transmembrane component, and the remaining bulk of the protein is extra-cellular (outside the cell). The transmembrane component consists of single chain
658:. E-cadherins play a vital role in cancer formation, as deregulation of E-cadherin functions is a crucial step in the formation of breast cancer tumors.
506:
128:
The cadherin family is essential in maintaining cell-cell contact and regulating cytoskeletal complexes. The cadherin superfamily includes cadherins,
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2938:"In the first extracellular domain of E-cadherin, heterophilic interactions, but not the conserved His-Ala-Val motif, are required for adhesion"
205:
repeats. Because cadherins are Ca dependent, they have five tandem extracellular domain repeats that act as the binding site for Ca ions.
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levels of these molecules increase during the luteal phase while their expression is regulated by progesterone with endometrial calcitonin.
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Reynolds AB, Carnahan RH (December 2004). "Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer".
216:
The functionality of cadherins relies upon the formation of two identical subunits, known as homodimers. The homodimeric cadherins create
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Cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during
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2574:
115:
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Moran CJ, Joyce M, McAnena OJ (April 2005). "CDH1 associated gastric cancer: a report of a family and review of the literature".
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1214:
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Cavallaro U, Schaffhauser B, Christofori G (February 2002). "Cadherins and the tumour progression: is it all in a switch?".
614:
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376:
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655:
368:
93:
89:
54:
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Beavon IR (August 2000). "The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation".
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Beavon IR (August 2000). "The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation".
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Protocadherins are the largest mammalian subgroup of the cadherin superfamily of homophilic cell-adhesion proteins.
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3190:
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Morales CP, Souza RF, Spechler SJ (November 2002). "Hallmarks of cancer progression in
Barrett's oesophagus".
602:
53:
to function, hence their name. Cell-cell adhesion is mediated by extracellular cadherin domains, whereas the
1400:
Angst BD, Marcozzi C, Magee AI (February 2001). "The cadherin superfamily: diversity in form and function".
21:
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414:
34:
2381:"The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins"
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3125:"The Involvement of Cell Adhesion Molecules, Tight Junctions, and Gap Junctions in Human Placentation"
3409:
3395:
2710:
1733:
543:
2701:
Hazan RB, Qiao R, Keren R, Badano I, Suyama K (April 2004). "Cadherin switch in tumor progression".
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1589:"Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants"
654:– E-cadherin (epithelial): E-cadherins are found in epithelial tissue; not to be confused with the
550:
511:
453:
Ribbon representation of a repeating unit in the extracellular E-cadherin ectodomain of the mouse (
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57:
associates with numerous adaptors and signaling proteins, collectively referred to as the cadherin
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Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, et al. (February 2007).
84:
may contain an excessive amount of intricate detail that may interest only a particular audience
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Adu-Gyamfi EA, Czika A, Gorleku PN, Ullah A, Panhwar Z, Ruan LL, et al. (February 2021).
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Corso G, Figueiredo J, De
Angelis SP, Corso F, Girardi A, Pereira J, et al. (June 2020).
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232:, bind to the cytoplasmic portion of the cadherin. Regulatory proteins include p-120 catenin,
38:
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Chun YS, Lindor NM, Smyrk TC, Petersen BT, Burgart LJ, Guilford PJ, et al. (July 2001).
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2224:"Beyond N-Cadherin, Relevance of Cadherins 5, 6 and 17 in Cancer Progression and Metastasis"
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1540:"Catenin-dependent cadherin function drives divisional segregation of spinal motor neurons"
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with cadherins present in the membranes of other cells through changing conformation from
145:
2097:"Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells"
1365:
Hulpiau P, van Roy F (February 2009). "Molecular evolution of the cadherin superfamily".
2901:
2714:
1970:
Gumbiner BM (August 2005). "Regulation of cadherin-mediated adhesion in morphogenesis".
1777:
Harris TJ, Tepass U (July 2010). "Adherens junctions: from molecules to morphogenesis".
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Harrison OJ, Jin X, Hong S, Bahna F, Ahlsen G, Brasch J, et al. (February 2011).
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2020:"Should I stay or should I go? Cadherin function and regulation in the neural crest"
1999:
1806:
1722:"Lifetime measurements reveal kinetic differences between homophilic cadherin bonds"
1706:
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1956:
1827:
Marie PJ, HaĂż E, Modrowski D, Revollo L, Mbalaviele G, Civitelli R (January 2014).
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698:
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359:
202:
2639:"Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated?"
2465:
Lodish H, Berk A, Kaiser C, Krieger M, Bretscher A, Ploegh H, et al. (2013).
2113:
2096:
1630:"Cadherin-mediated cell sorting not determined by binding or adhesion specificity"
555:
3200:
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RNA splicing mechanisms. Invertebrates contain fewer than 20 types of cadherins.
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Bryant DM, Stow JL (August 2004). "The ins and outs of E-cadherin trafficking".
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2173:"Tumor suppressor gene E-cadherin and its role in normal and malignant cells"
296:-catenin to the homodimer increases the stability of the classical cadherin.
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any relevant information, and removing excessive detail that may be against
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Different members of the cadherin family are found in different locations.
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10.1002/1097-0142(20010701)92:1<181::AID-CNCR1307>3.0.CO;2-J
1506:
3900:
3180:
3082:"Single-molecule studies of classical and desmosomal cadherin adhesion"
2989:
2972:
2592:
10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D
2507:
1442:"Single-molecule studies of classical and desmosomal cadherin adhesion"
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that let cells adhere to each other. Cadherins are a class of type-1
1983:
1927:(November 2000). "Cadherins in embryonic and neural morphogenesis".
1829:"Cadherin-mediated cell-cell adhesion and signaling in the skeleton"
1790:
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3431:
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3324:
3299:
2902:"Polycystin: new aspects of structure, function, and regulation"
2851:"E-cadherin-catenin cell-cell adhesion complex and human cancer"
2850:
1136:
1130:
1118:
1106:
1092:
720:
716:
712:
702:
676:– P-cadherin (placental): P-cadherins are found in the placenta.
661:
626:
571:
482:
3765:
3214:
1318:"CDH2 and CDH11 act as regulators of stem cell fate decisions"
68:
50:
1367:
209:
Their extracellular domain interacts with two separate
1881:"Biophysical basis of cadherin mediated cell-cell adhesion"
1538:
Bello SM, Millo H, Rajebhosale M, Price SR (January 2012).
2806:"CDH1 germline mutation in hereditary gastric carcinoma"
1720:
Bayas MV, Leung A, Evans E, Leckband D (February 2006).
2469:(Seventh ed.). New York: Worth Publ. p. 934.
664:– N-cadherin (neural): N-cadherins are found in neurons
2849:
Wijnhoven BP, Dinjens WN, Pignatelli M (August 2000).
2682:
1918:
1916:
1879:
Priest AV, Shafraz O, Sivasankar S (September 2017).
322:
302:
282:
258:
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154:
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Priest AV, Koirala R, Sivasankar S (December 2019).
1440:
Priest AV, Koirala R, Sivasankar S (December 2019).
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196:
Domain organization of different types of cadherins
328:
308:
288:
264:
244:
160:
2013:
2011:
2009:
1491:"Planar cell polarity in development and disease"
1587:Duguay D, Foty RA, Steinberg MS (January 2003).
1311:
1309:
2575:"Mutations of the human E-cadherin (CDH1) gene"
2573:Berx G, Becker KF, Höfler H, van Roy F (1998).
2261:
2259:
1874:
1872:
3777:
3226:
3129:Reproductive Sciences (Thousand Oaks, Calif.)
2909:Journal of the American Society of Nephrology
1822:
1820:
1818:
1816:
1435:
1433:
1431:
33:(named for "calcium-dependent adhesion") are
8:
2777:Seminars in Cell & Developmental Biology
426:Correlation to endometrium and embryogenesis
3173:- view cadherin structure in interactive 3D
2228:International Journal of Molecular Sciences
2065:
2063:
2018:Taneyhill LA, Schiffmacher AT (June 2017).
3784:
3770:
3762:
3474:
3465:
3258:
3233:
3219:
3211:
2936:Renaud-Young M, Gallin WJ (October 2002).
2703:Annals of the New York Academy of Sciences
2496:Journal of Cellular and Molecular Medicine
2492:"E-cadherin deregulation in breast cancer"
562:
447:
3140:
3105:
3086:Current Opinion in Biomedical Engineering
2988:
2953:
2874:
2831:
2821:
2804:Wang HD, Ren J, Zhang L (November 2004).
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1446:Current Opinion in Biomedical Engineering
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153:
116:Learn how and when to remove this message
1628:Niessen CM, Gumbiner BM (January 2002).
20:
16:Calcium-dependent cell adhesion molecule
1489:Butler MT, Wallingford JB (June 2017).
1305:
1199:– cadherin 23 (neurosensory epithelium)
2460:
2458:
2431:Encyclopedia of Molecular Pharmacology
1972:Nature Reviews. Molecular Cell Biology
1929:Nature Reviews. Molecular Cell Biology
1779:Nature Reviews. Molecular Cell Biology
1316:Alimperti S, Andreadis ST (May 2015).
438:
2748:European Journal of Surgical Oncology
2222:Casal JI, Bartolomé RA (2019-07-09).
1923:Tepass U, Truong K, Godt D, Ikura M,
1495:Nature Reviews Molecular Cell Biology
140:, and more. In structure, they share
7:
1294:List of target antigens in pemphigus
1115:– VE-cadherin (vascular endothelial)
670:– cadherin 12, type 2 (N-cadherin 2)
3045:Molecular and Cellular Biochemistry
2942:The Journal of Biological Chemistry
1145:– cadherin 10, type 2 (T2-cadherin)
2428:Offermanns S, Rosenthal W (2008).
2072:The Molecular Biology of Cadherins
1139:– cadherin 9, type 2 (T1-cadherin)
98:Knowledge (XXG)'s inclusion policy
14:
3008:Pathology & Oncology Research
2810:World Journal of Gastroenterology
1157:– T-cadherin – H-cadherin (heart)
373:epithelial–mesenchymal transition
144:, which are the extracellular Ca-
2867:10.1046/j.1365-2168.2000.01513.x
179:. For example, cells containing
73:
2973:"Cadherin adhesome at a glance"
1175:– LI cadherin (liver-intestine)
276:. Binding of p-120 catenin and
2855:The British Journal of Surgery
2074:. Elsevier. pp. 264–274.
1833:Calcified Tissue International
1556:10.1523/jneurosci.4382-11.2012
377:induced pluripotent stem cells
55:intracellular cytoplasmic tail
1:
2971:Zaidel-Bar R (January 2013).
2558:10.1016/S0959-8049(00)00158-1
2323:10.1016/S0304-3835(01)00759-5
2280:10.1016/S0140-6736(02)11569-8
2150:10.1016/S0959-8049(00)00158-1
2114:10.1158/1535-7163.MCT-06-0609
2101:Molecular Cancer Therapeutics
1606:10.1016/S0012-1606(02)00016-7
566:Available protein structures:
2789:10.1016/j.semcdb.2004.09.003
1691:10.1016/0092-8674(87)90525-3
1379:10.1016/j.biocel.2008.09.027
656:APC/C activator protein CDH1
632:for other Cadherin families.
3098:10.1016/j.cobme.2019.08.006
2434:. Springer. pp. 306–.
2171:Nives Pećina-Šlaus (2003).
1898:10.1016/j.yexcr.2017.03.015
1746:10.1529/biophysj.105.069583
1634:The Journal of Cell Biology
1544:The Journal of Neuroscience
1458:10.1016/j.cobme.2019.08.006
4032:
3699:Lymphocyte homing receptor
3142:10.1007/s43032-020-00364-7
3057:10.1007/s11010-020-03920-6
2760:10.1016/j.ejso.2004.12.010
2546:European Journal of Cancer
2138:European Journal of Cancer
1885:Experimental Cell Research
1151:– OB-cadherin (osteoblast)
731:
3020:10.1007/s12253-018-0500-y
2622:10.1016/j.tcb.2004.07.007
2397:10.1016/j.str.2010.11.016
2358:10.1134/S2079057016010045
1845:10.1007/s00223-013-9733-7
1334:10.1016/j.scr.2015.02.002
624:
561:
446:
3731:Carcinoembryonic antigen
3585:Unconventional/ungrouped
2900:Wilson PD (April 2001).
2823:10.3748/wjg.v10.i21.3088
1163:– M-cadherin (myotubule)
1100:Unconventional/ungrouped
442:Cadherin domain (repeat)
3811:Cell adhesion molecules
3246:cell adhesion molecules
2977:Journal of Cell Science
2723:10.1196/annals.1294.016
2552:(13 Spec No): 1607–20.
2346:Advances in Gerontology
2144:(13 Spec No): 1607–20.
1402:Journal of Cell Science
336:-catenin and vinculin.
329:{\displaystyle \alpha }
309:{\displaystyle \alpha }
245:{\displaystyle \alpha }
35:cell adhesion molecules
26:and to actin filaments.
4011:Transmembrane proteins
4006:Cell adhesion proteins
2955:10.1074/jbc.M201256200
2610:Trends in Cell Biology
2467:Molecular Cell Biology
2190:10.1186/1475-2867-3-17
1109:– R-cadherin (retinal)
330:
310:
290:
289:{\displaystyle \beta }
266:
265:{\displaystyle \beta }
246:
230:α-, β-, and γ-catenins
197:
162:
161:{\displaystyle \beta }
43:transmembrane proteins
27:
3438:Glycoprotein IIb/IIIa
3191:The Cadherin Resource
1646:10.1083/jcb.200108040
1593:Developmental Biology
1414:10.1242/jcs.114.4.629
1193:– cadherin 20, type 2
1187:– cadherin 19, type 2
1181:– cadherin 18, type 2
1121:– K-cadherin (kidney)
400:Correlation to cancer
331:
311:
291:
267:
247:
195:
163:
45:, and they depend on
37:important in forming
24:
3410:Macrophage-1 antigen
3396:Integrin alphaXbeta2
2241:10.3390/ijms20133373
1133:– cadherin 8, type 2
1127:– cadherin 7, type 2
320:
300:
280:
256:
236:
152:
3275:Myelin protein zero
3254:Calcium-independent
3186:The cadherin family
2921:10.1681/ASN.V124834
2715:2004NYASA1014..155H
1738:2006BpJ....90.1385B
1726:Biophysical Journal
1507:10.1038/nrm.2017.11
2990:10.1242/jcs.111559
2508:10.1111/jcmm.15140
1322:Stem Cell Research
1284:Masatoshi Takeichi
326:
306:
286:
262:
242:
218:cell-cell adhesion
198:
158:
39:adherens junctions
28:
3993:
3992:
3892:membrane proteins
3815:Adherens junction
3759:
3758:
3687:
3686:
3655:
3654:
3461:Calcium-dependent
3455:
3454:
3242:Membrane proteins
2502:(11): 5930–5936.
2476:978-1-4292-3413-9
2441:978-3-540-38916-3
2081:978-0-12-394311-8
2036:10.1002/dvg.23028
636:
635:
620:
619:
615:structure summary
387:Tumour metastasis
126:
125:
118:
4023:
3786:
3779:
3772:
3763:
3475:
3466:
3259:
3235:
3228:
3221:
3212:
3154:
3144:
3119:
3109:
3076:
3039:
3014:(4): 1457–1465.
3002:
2992:
2967:
2957:
2948:(42): 39609–16.
2932:
2906:
2896:
2878:
2845:
2835:
2825:
2800:
2771:
2742:
2697:
2676:
2658:
2633:
2604:
2594:
2569:
2530:
2529:
2519:
2487:
2481:
2480:
2462:
2453:
2452:
2450:
2448:
2425:
2419:
2418:
2408:
2376:
2370:
2369:
2341:
2335:
2334:
2306:
2300:
2299:
2274:(9345): 1587–9.
2263:
2254:
2253:
2243:
2219:
2213:
2212:
2202:
2192:
2168:
2162:
2161:
2133:
2127:
2126:
2116:
2092:
2086:
2085:
2067:
2058:
2057:
2047:
2015:
2004:
2003:
1967:
1961:
1960:
1941:10.1038/35040042
1920:
1911:
1910:
1900:
1876:
1867:
1866:
1856:
1824:
1811:
1810:
1774:
1768:
1767:
1757:
1717:
1711:
1710:
1674:
1668:
1667:
1657:
1625:
1619:
1618:
1608:
1584:
1578:
1577:
1567:
1535:
1529:
1528:
1518:
1486:
1480:
1479:
1469:
1437:
1426:
1425:
1408:(Pt 4): 629–41.
1397:
1391:
1390:
1362:
1356:
1355:
1345:
1313:
563:
462:
451:
439:
335:
333:
332:
327:
315:
313:
312:
307:
295:
293:
292:
287:
271:
269:
268:
263:
252:-catenin,
251:
249:
248:
243:
167:
165:
164:
159:
142:cadherin repeats
121:
114:
110:
107:
101:
77:
76:
69:
4031:
4030:
4026:
4025:
4024:
4022:
4021:
4020:
3996:
3995:
3994:
3989:
3955:
3917:
3796:
3790:
3760:
3755:
3683:
3651:
3580:
3552:
3499:
3451:
3368:
3248:
3239:
3177:Cadherin domain
3162:
3157:
3122:
3079:
3042:
3005:
2983:(Pt 2): 373–8.
2970:
2935:
2904:
2899:
2861:(8): 992–1005.
2848:
2816:(21): 3088–93.
2803:
2774:
2745:
2700:
2679:
2636:
2607:
2572:
2543:
2539:
2537:Further reading
2534:
2533:
2489:
2488:
2484:
2477:
2464:
2463:
2456:
2446:
2444:
2442:
2427:
2426:
2422:
2378:
2377:
2373:
2343:
2342:
2338:
2308:
2307:
2303:
2265:
2264:
2257:
2221:
2220:
2216:
2177:Cancer Cell Int
2170:
2169:
2165:
2135:
2134:
2130:
2094:
2093:
2089:
2082:
2069:
2068:
2061:
2017:
2016:
2007:
1984:10.1038/nrm1699
1969:
1968:
1964:
1922:
1921:
1914:
1878:
1877:
1870:
1826:
1825:
1814:
1791:10.1038/nrm2927
1776:
1775:
1771:
1719:
1718:
1714:
1676:
1675:
1671:
1627:
1626:
1622:
1586:
1585:
1581:
1537:
1536:
1532:
1488:
1487:
1483:
1439:
1438:
1429:
1399:
1398:
1394:
1364:
1363:
1359:
1315:
1314:
1307:
1302:
1280:
1275:
1102:
1097:
736:
730:
683:
645:
464:
454:
437:
428:
402:
389:
347:
342:
318:
317:
298:
297:
278:
277:
254:
253:
234:
233:
190:
150:
149:
146:binding domains
122:
111:
105:
102:
88:Please help by
87:
78:
74:
67:
17:
12:
11:
5:
4029:
4027:
4019:
4018:
4013:
4008:
3998:
3997:
3991:
3990:
3988:
3987:
3973:
3963:
3961:
3957:
3956:
3954:
3953:
3948:
3946:Focal adhesion
3943:
3934:
3928:
3926:
3919:
3918:
3916:
3915:
3914:
3913:
3908:
3903:
3896:Tight junction
3887:
3886:
3885:
3884:
3879:
3874:
3859:
3858:
3857:
3856:
3837:
3836:
3835:
3834:
3824:
3823:
3822:
3807:
3805:
3798:
3797:
3791:
3789:
3788:
3781:
3774:
3766:
3757:
3756:
3754:
3753:
3748:
3743:
3738:
3733:
3727:
3726:
3710:
3705:
3695:
3693:
3689:
3688:
3685:
3684:
3682:
3681:
3676:
3671:
3665:
3663:
3657:
3656:
3653:
3652:
3650:
3649:
3644:
3639:
3634:
3629:
3624:
3619:
3614:
3609:
3604:
3599:
3594:
3588:
3586:
3582:
3581:
3579:
3578:
3573:
3568:
3562:
3560:
3554:
3553:
3551:
3550:
3532:
3509:
3507:
3501:
3500:
3498:
3497:
3492:
3487:
3481:
3479:
3472:
3463:
3457:
3456:
3453:
3452:
3450:
3449:
3435:
3421:
3407:
3393:
3378:
3376:
3370:
3369:
3367:
3366:
3365:
3364:
3359:
3354:
3349:
3344:
3339:
3329:
3328:
3327:
3322:
3317:
3312:
3302:
3297:
3292:
3278:
3267:
3265:
3256:
3250:
3249:
3240:
3238:
3237:
3230:
3223:
3215:
3209:
3208:
3204:
3193:
3188:
3183:
3174:
3161:
3160:External links
3158:
3156:
3155:
3135:(2): 305–320.
3120:
3077:
3051:(2): 535–551.
3040:
3003:
2968:
2933:
2897:
2846:
2801:
2772:
2743:
2698:
2677:
2634:
2605:
2579:Human Mutation
2570:
2540:
2538:
2535:
2532:
2531:
2482:
2475:
2454:
2440:
2420:
2371:
2336:
2311:Cancer Letters
2301:
2255:
2214:
2163:
2128:
2107:(2): 391–403.
2087:
2080:
2070:Roy F (2013).
2059:
2005:
1962:
1912:
1868:
1812:
1769:
1732:(4): 1385–95.
1712:
1669:
1640:(2): 389–399.
1620:
1579:
1550:(2): 490–505.
1530:
1501:(6): 375–388.
1481:
1427:
1392:
1357:
1304:
1303:
1301:
1298:
1297:
1296:
1291:
1286:
1279:
1276:
1274:
1273:
1268:
1263:
1258:
1253:
1243:
1230:
1217:
1200:
1194:
1188:
1182:
1176:
1170:
1169:– KSP-cadherin
1164:
1158:
1152:
1146:
1140:
1134:
1128:
1122:
1116:
1110:
1103:
1101:
1098:
1096:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
766:
761:
756:
751:
746:
740:
732:Main article:
729:
728:Protocadherins
726:
725:
724:
706:
682:
679:
678:
677:
671:
665:
659:
644:
641:
634:
633:
622:
621:
618:
617:
612:
606:
605:
592:
586:
585:
575:
568:
567:
559:
558:
553:
547:
546:
533:
527:
526:
521:
515:
514:
509:
503:
502:
497:
491:
490:
485:
479:
478:
475:
471:
470:
466:
465:
452:
444:
443:
436:
433:
427:
424:
401:
398:
388:
385:
365:cardiomyocytes
346:
343:
341:
338:
325:
305:
285:
272:-catenin, and
261:
241:
189:
186:
157:
130:protocadherins
124:
123:
81:
79:
72:
66:
63:
15:
13:
10:
9:
6:
4:
3:
2:
4028:
4017:
4014:
4012:
4009:
4007:
4004:
4003:
4001:
3985:
3981:
3977:
3974:
3972:
3968:
3965:
3964:
3962:
3958:
3952:
3949:
3947:
3944:
3942:
3938:
3937:Hemidesmosome
3935:
3933:
3930:
3929:
3927:
3925:
3920:
3912:
3909:
3907:
3904:
3902:
3899:
3898:
3897:
3893:
3889:
3888:
3883:
3880:
3878:
3875:
3873:
3870:
3869:
3868:
3864:
3861:
3860:
3855:
3852:
3851:
3850:
3846:
3842:
3839:
3838:
3833:
3830:
3829:
3828:
3825:
3821:
3818:
3817:
3816:
3812:
3809:
3808:
3806:
3804:
3799:
3795:
3787:
3782:
3780:
3775:
3773:
3768:
3767:
3764:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3732:
3729:
3728:
3724:
3720:
3716:
3715:
3711:
3709:
3706:
3704:
3700:
3697:
3696:
3694:
3690:
3680:
3677:
3675:
3672:
3670:
3667:
3666:
3664:
3662:
3658:
3648:
3645:
3643:
3640:
3638:
3635:
3633:
3630:
3628:
3625:
3623:
3620:
3618:
3615:
3613:
3610:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3590:
3589:
3587:
3583:
3577:
3574:
3572:
3569:
3567:
3564:
3563:
3561:
3559:
3558:Protocadherin
3555:
3548:
3544:
3540:
3536:
3533:
3530:
3526:
3522:
3518:
3514:
3511:
3510:
3508:
3506:
3502:
3496:
3493:
3491:
3488:
3486:
3483:
3482:
3480:
3476:
3473:
3471:
3467:
3464:
3462:
3458:
3447:
3443:
3439:
3436:
3433:
3429:
3425:
3422:
3419:
3415:
3411:
3408:
3405:
3401:
3397:
3394:
3391:
3387:
3383:
3380:
3379:
3377:
3375:
3371:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3334:
3333:
3330:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3307:
3306:
3303:
3301:
3298:
3296:
3293:
3290:
3286:
3282:
3279:
3276:
3272:
3269:
3268:
3266:
3264:
3260:
3257:
3255:
3251:
3247:
3243:
3236:
3231:
3229:
3224:
3222:
3217:
3216:
3213:
3207:
3205:
3203:
3202:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3178:
3175:
3172:
3171:
3168:
3164:
3163:
3159:
3152:
3148:
3143:
3138:
3134:
3130:
3126:
3121:
3117:
3113:
3108:
3103:
3099:
3095:
3091:
3087:
3083:
3078:
3074:
3070:
3066:
3062:
3058:
3054:
3050:
3046:
3041:
3037:
3033:
3029:
3025:
3021:
3017:
3013:
3009:
3004:
3000:
2996:
2991:
2986:
2982:
2978:
2974:
2969:
2965:
2961:
2956:
2951:
2947:
2943:
2939:
2934:
2930:
2926:
2922:
2918:
2915:(4): 834–45.
2914:
2910:
2903:
2898:
2894:
2890:
2886:
2882:
2877:
2872:
2868:
2864:
2860:
2856:
2852:
2847:
2843:
2839:
2834:
2829:
2824:
2819:
2815:
2811:
2807:
2802:
2798:
2794:
2790:
2786:
2783:(6): 657–63.
2782:
2778:
2773:
2769:
2765:
2761:
2757:
2754:(3): 259–64.
2753:
2749:
2744:
2740:
2736:
2732:
2728:
2724:
2720:
2716:
2712:
2709:(1): 155–63.
2708:
2704:
2699:
2695:
2691:
2687:
2683:
2678:
2674:
2670:
2666:
2662:
2657:
2652:
2648:
2644:
2640:
2635:
2631:
2627:
2623:
2619:
2616:(8): 427–34.
2615:
2611:
2606:
2602:
2598:
2593:
2588:
2585:(4): 226–37.
2584:
2580:
2576:
2571:
2567:
2563:
2559:
2555:
2551:
2547:
2542:
2541:
2536:
2527:
2523:
2518:
2513:
2509:
2505:
2501:
2497:
2493:
2486:
2483:
2478:
2472:
2468:
2461:
2459:
2455:
2443:
2437:
2433:
2432:
2424:
2421:
2416:
2412:
2407:
2402:
2398:
2394:
2391:(2): 244–56.
2390:
2386:
2382:
2375:
2372:
2367:
2363:
2359:
2355:
2351:
2347:
2340:
2337:
2332:
2328:
2324:
2320:
2316:
2312:
2305:
2302:
2297:
2293:
2289:
2285:
2281:
2277:
2273:
2269:
2262:
2260:
2256:
2251:
2247:
2242:
2237:
2233:
2229:
2225:
2218:
2215:
2210:
2206:
2201:
2196:
2191:
2186:
2182:
2178:
2174:
2167:
2164:
2159:
2155:
2151:
2147:
2143:
2139:
2132:
2129:
2124:
2120:
2115:
2110:
2106:
2102:
2098:
2091:
2088:
2083:
2077:
2073:
2066:
2064:
2060:
2055:
2051:
2046:
2041:
2037:
2033:
2030:(6): e23028.
2029:
2025:
2021:
2014:
2012:
2010:
2006:
2001:
1997:
1993:
1989:
1985:
1981:
1978:(8): 622–34.
1977:
1973:
1966:
1963:
1958:
1954:
1950:
1946:
1942:
1938:
1935:(2): 91–100.
1934:
1930:
1926:
1919:
1917:
1913:
1908:
1904:
1899:
1894:
1890:
1886:
1882:
1875:
1873:
1869:
1864:
1860:
1855:
1850:
1846:
1842:
1838:
1834:
1830:
1823:
1821:
1819:
1817:
1813:
1808:
1804:
1800:
1796:
1792:
1788:
1785:(7): 502–14.
1784:
1780:
1773:
1770:
1765:
1761:
1756:
1751:
1747:
1743:
1739:
1735:
1731:
1727:
1723:
1716:
1713:
1708:
1704:
1700:
1696:
1692:
1688:
1685:(6): 987–94.
1684:
1680:
1673:
1670:
1665:
1661:
1656:
1651:
1647:
1643:
1639:
1635:
1631:
1624:
1621:
1616:
1612:
1607:
1602:
1599:(2): 309–23.
1598:
1594:
1590:
1583:
1580:
1575:
1571:
1566:
1561:
1557:
1553:
1549:
1545:
1541:
1534:
1531:
1526:
1522:
1517:
1512:
1508:
1504:
1500:
1496:
1492:
1485:
1482:
1477:
1473:
1468:
1463:
1459:
1455:
1451:
1447:
1443:
1436:
1434:
1432:
1428:
1423:
1419:
1415:
1411:
1407:
1403:
1396:
1393:
1388:
1384:
1380:
1376:
1373:(2): 349–69.
1372:
1368:
1361:
1358:
1353:
1349:
1344:
1339:
1335:
1331:
1328:(3): 270–82.
1327:
1323:
1319:
1312:
1310:
1306:
1299:
1295:
1292:
1290:
1287:
1285:
1282:
1281:
1277:
1272:
1269:
1267:
1264:
1262:
1259:
1257:
1254:
1251:
1247:
1244:
1242:
1238:
1234:
1231:
1229:
1225:
1221:
1218:
1216:
1212:
1208:
1204:
1201:
1198:
1195:
1192:
1189:
1186:
1183:
1180:
1177:
1174:
1171:
1168:
1165:
1162:
1159:
1156:
1153:
1150:
1147:
1144:
1141:
1138:
1135:
1132:
1129:
1126:
1123:
1120:
1117:
1114:
1111:
1108:
1105:
1104:
1099:
1094:
1091:
1089:
1086:
1084:
1081:
1079:
1076:
1074:
1071:
1069:
1066:
1064:
1061:
1059:
1056:
1054:
1051:
1049:
1046:
1044:
1041:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
989:
986:
984:
981:
979:
976:
974:
971:
969:
966:
964:
961:
959:
956:
954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
929:
926:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
741:
739:
735:
734:Protocadherin
727:
722:
718:
714:
710:
707:
704:
700:
696:
692:
688:
685:
684:
680:
675:
672:
669:
666:
663:
660:
657:
653:
650:
649:
648:
642:
640:
631:
628:
623:
616:
613:
611:
607:
604:
600:
596:
593:
591:
587:
583:
579:
576:
573:
569:
564:
560:
557:
554:
552:
548:
545:
541:
537:
534:
532:
528:
525:
522:
520:
516:
513:
510:
508:
504:
501:
498:
496:
492:
489:
486:
484:
480:
476:
472:
467:
461:
457:
450:
445:
440:
434:
432:
425:
423:
421:
416:
412:
406:
399:
397:
393:
386:
384:
380:
378:
374:
370:
369:embryogenesis
366:
361:
357:
353:
344:
339:
337:
323:
303:
283:
275:
259:
239:
231:
227:
223:
219:
214:
212:
208:
204:
194:
187:
185:
182:
178:
173:
171:
155:
147:
143:
139:
135:
131:
120:
117:
109:
99:
95:
91:
85:
82:This section
80:
71:
70:
64:
62:
60:
56:
52:
48:
44:
40:
36:
32:
23:
19:
3932:Basal lamina
3863:Cytoskeleton
3845:Gap junction
3841:Ion channels
3819:
3792:Proteins of
3712:
3469:
3199:
3165:
3132:
3128:
3089:
3085:
3048:
3044:
3011:
3007:
2980:
2976:
2945:
2941:
2912:
2908:
2858:
2854:
2813:
2809:
2780:
2776:
2751:
2747:
2706:
2702:
2685:
2681:
2649:(1): 181–7.
2646:
2642:
2613:
2609:
2582:
2578:
2549:
2545:
2499:
2495:
2485:
2466:
2445:. Retrieved
2430:
2423:
2388:
2384:
2374:
2352:(1): 36–43.
2349:
2345:
2339:
2317:(2): 123–8.
2314:
2310:
2304:
2271:
2267:
2234:(13): 3373.
2231:
2227:
2217:
2180:
2176:
2166:
2141:
2137:
2131:
2104:
2100:
2090:
2071:
2027:
2023:
1975:
1971:
1965:
1932:
1928:
1891:(1): 10–13.
1888:
1884:
1839:(1): 46–54.
1836:
1832:
1782:
1778:
1772:
1729:
1725:
1715:
1682:
1678:
1672:
1637:
1633:
1623:
1596:
1592:
1582:
1547:
1543:
1533:
1498:
1494:
1484:
1449:
1445:
1405:
1401:
1395:
1370:
1366:
1360:
1325:
1321:
737:
646:
637:
429:
407:
403:
394:
390:
381:
360:neural plate
348:
225:
221:
215:
210:
206:
203:glycoprotein
199:
174:
141:
138:desmocollins
127:
112:
103:
90:spinning off
83:
30:
29:
18:
3980:Stereocilia
3924:cell–matrix
3877:Plakoglobin
3872:Desmoplakin
3535:Desmocollin
3167:Proteopedia
2688:(1): 5–14.
2447:14 December
709:Desmocollin
469:Identifiers
356:neurulation
352:E-cadherins
345:Development
224:-dimers to
177:development
134:desmogleins
4000:Categories
3976:Microvilli
3971:Kinocilium
3941:Tonofibril
3882:Tonofibril
3832:Desmoglein
3794:epithelium
3708:L-selectin
3679:P-selectin
3674:L-selectin
3669:E-selectin
3592:T-cadherin
3513:Desmoglein
3505:Desmosomal
2876:1765/56571
2183:(17): 17.
1300:References
687:Desmoglein
681:Desmosomal
578:structures
551:Membranome
181:N-cadherin
94:relocating
65:Background
4016:Cadherins
3951:Costamere
3867:Desmosome
3827:Desmosome
3803:cell–cell
3661:Selectins
3478:Classical
3470:Cadherins
3374:Integrins
3305:L1 family
3201:IPR002126
3092:: 43–50.
3073:222153001
2385:Structure
2250:1422-0067
1452:: 43–50.
1256:LOC389118
643:Classical
524:PDOC00205
500:IPR002126
463:)
379:(iPSCs).
358:, when a
324:α
304:α
284:β
260:β
240:α
188:Structure
156:β
106:July 2023
31:Cadherins
3911:MARVELD2
3906:Occludin
3854:Connexin
3849:Connexon
3820:Cadherin
3801:Lateral/
3714:integrin
3263:IgSF CAM
3196:InterPro
3170:Cadherin
3151:33146876
3116:31742239
3065:33011884
3036:53083365
3028:30368729
2999:23547085
2964:12154084
2929:11274246
2885:10931041
2842:15457549
2797:15561585
2768:15780560
2739:37486403
2731:15153430
2694:16761612
2673:11052015
2665:11443625
2630:15308209
2566:10959047
2526:32301282
2415:21300292
2366:87472683
2331:11804738
2296:22401564
2288:12443613
2209:14613514
2158:10959047
2123:17272646
2054:28253541
2000:25094246
1992:16025097
1949:11253370
1925:Peifer M
1907:28300566
1863:23657489
1807:13638902
1799:20571587
1764:16326909
1707:21428349
1664:11790800
1615:12645933
1574:22238085
1525:28293032
1476:31742239
1422:11171368
1387:18848899
1352:25771201
1278:See also
1028:PCDHGA12
1023:PCDHGA11
1018:PCDHGA10
595:RCSB PDB
495:InterPro
477:Cadherin
420:catenins
411:catenins
340:Function
274:vinculin
59:adhesome
3901:Claudin
3198::
3181:PROSITE
3107:6859941
2893:3083613
2833:4611247
2711:Bibcode
2601:9744472
2517:7294130
2406:3070544
2045:5468476
2024:Genesis
1957:1632053
1854:4272239
1755:1367289
1734:Bibcode
1699:3621349
1655:2199232
1565:3292792
1516:5826606
1467:6859941
1343:4439315
1289:Catenin
1078:PCDHGC5
1073:PCDHGC4
1068:PCDHGC3
1063:PCDHGB7
1058:PCDHGB6
1053:PCDHGB5
1048:PCDHGB4
1043:PCDHGB3
1038:PCDHGB2
1033:PCDHGB1
1013:PCDHGA9
1008:PCDHGA8
1003:PCDHGA7
998:PCDHGA6
993:PCDHGA5
988:PCDHGA4
983:PCDHGA3
978:PCDHGA2
973:PCDHGA1
968:PCDHB18
963:PCDHB17
958:PCDHB16
953:PCDHB15
948:PCDHB14
943:PCDHB13
938:PCDHB12
933:PCDHB11
928:PCDHB10
878:PCDHAC2
873:PCDHAC1
868:PCDHA13
863:PCDHA12
858:PCDHA11
853:PCDHA10
769:PCDH11X
519:PROSITE
488:PF00028
47:calcium
3960:Apical
3922:Basal/
3890:other
3576:PCDH19
3571:PCDH15
3442:ITGA2B
3332:Nectin
3310:L1-CAM
3300:PE-CAM
3295:VCAM-1
3149:
3114:
3104:
3071:
3063:
3034:
3026:
2997:
2962:
2927:
2891:
2883:
2840:
2830:
2795:
2766:
2737:
2729:
2692:
2671:
2663:
2643:Cancer
2628:
2599:
2564:
2524:
2514:
2473:
2438:
2413:
2403:
2364:
2329:
2294:
2286:
2268:Lancet
2248:
2207:
2200:270068
2197:
2156:
2121:
2078:
2052:
2042:
1998:
1990:
1955:
1947:
1905:
1861:
1851:
1805:
1797:
1762:
1752:
1705:
1697:
1662:
1652:
1613:
1572:
1562:
1523:
1513:
1474:
1464:
1420:
1385:
1350:
1340:
1266:RESDA1
1241:CLSTN3
1237:CLSTN2
1233:CLSTN1
1228:CELSR3
1224:CELSR2
1220:CELSR1
923:PCDHB9
918:PCDHB8
913:PCDHB7
908:PCDHB6
903:PCDHB5
898:PCDHB4
893:PCDHB3
888:PCDHB2
883:PCDHB1
848:PCDHA9
843:PCDHA8
838:PCDHA7
833:PCDHA6
828:PCDHA5
823:PCDHA4
818:PCDHA3
813:PCDHA2
808:PCDHA1
803:PCDH20
798:PCDH19
793:PCDH18
788:PCDH17
783:PCDH15
778:PCDH12
764:PCDH10
630:CL0159
610:PDBsum
584:
574:
544:SUPFAM
474:Symbol
207:
170:CELSR1
3967:Cilia
3751:EpCAM
3746:CD146
3723:LFA-1
3719:VLA-4
3692:Other
3647:CDH10
3637:CDH17
3632:CDH16
3627:CDH15
3622:CDH12
3617:CDH11
3566:PCDH1
3446:ITGB3
3428:CD49d
3424:VLA-4
3414:CD11b
3400:CD11c
3386:CD11a
3382:LFA-1
3362:CD155
3357:CADM3
3352:CADM1
3347:PVRL3
3342:PVRL2
3337:PVRL1
3320:NFASC
3315:NRCAM
3271:N-CAM
3069:S2CID
3032:S2CID
2905:(PDF)
2889:S2CID
2735:S2CID
2669:S2CID
2362:S2CID
2292:S2CID
1996:S2CID
1953:S2CID
1803:S2CID
1703:S2CID
1261:PCLKC
1250:DCHS2
1246:DCHS1
1215:CDH28
1211:CDH26
1207:CDH24
1203:CDH22
1197:CDH23
1191:CDH20
1185:CDH19
1179:CDH18
1173:CDH17
1167:CDH16
1161:CDH15
1155:CDH13
1149:CDH11
1143:CDH10
759:PCDH9
754:PCDH8
749:PCDH7
744:PCDH1
668:CDH12
540:SCOPe
531:SCOP2
507:SMART
435:Types
226:trans
211:trans
49:(Ca)
3984:STRC
3741:CD44
3736:CD24
3703:CD44
3642:CDH9
3612:CDH8
3607:CDH6
3602:CDH5
3597:CDH4
3547:DSC3
3543:DSC2
3539:DSC1
3529:DSG4
3525:DSG3
3521:DSG2
3517:DSG1
3495:CDH3
3490:CDH2
3485:CDH1
3432:CD29
3418:CD18
3404:CD18
3390:CD18
3325:CHL1
3281:ICAM
3147:PMID
3112:PMID
3061:PMID
3024:PMID
2995:PMID
2960:PMID
2925:PMID
2881:PMID
2838:PMID
2793:PMID
2764:PMID
2727:PMID
2707:1014
2690:PMID
2661:PMID
2626:PMID
2597:PMID
2562:PMID
2522:PMID
2471:ISBN
2449:2010
2436:ISBN
2411:PMID
2327:PMID
2284:PMID
2246:ISSN
2205:PMID
2154:PMID
2119:PMID
2076:ISBN
2050:PMID
1988:PMID
1945:PMID
1903:PMID
1859:PMID
1795:PMID
1760:PMID
1695:PMID
1679:Cell
1660:PMID
1611:PMID
1570:PMID
1521:PMID
1472:PMID
1418:PMID
1383:PMID
1348:PMID
1137:CDH9
1131:CDH8
1125:CDH7
1119:CDH6
1113:CDH5
1107:CDH4
1093:FAT4
1088:FAT2
721:DSC3
717:DSC2
713:DSC1
703:DSG4
699:DSG3
695:DSG2
691:DSG1
674:CDH3
662:CDH2
652:CDH1
627:Pfam
625:See
603:PDBj
599:PDBe
582:ECOD
572:Pfam
536:1nci
483:Pfam
460:3Q2V
415:CAMs
51:ions
3179:in
3137:doi
3102:PMC
3094:doi
3053:doi
3049:476
3016:doi
2985:doi
2981:126
2950:doi
2946:277
2917:doi
2871:hdl
2863:doi
2828:PMC
2818:doi
2785:doi
2756:doi
2719:doi
2651:doi
2618:doi
2587:doi
2554:doi
2512:PMC
2504:doi
2401:PMC
2393:doi
2354:doi
2319:doi
2315:176
2276:doi
2272:360
2236:doi
2195:PMC
2185:doi
2146:doi
2109:doi
2040:PMC
2032:doi
1980:doi
1937:doi
1893:doi
1889:358
1849:PMC
1841:doi
1787:doi
1750:PMC
1742:doi
1687:doi
1650:PMC
1642:doi
1638:156
1601:doi
1597:253
1560:PMC
1552:doi
1511:PMC
1503:doi
1462:PMC
1454:doi
1410:doi
1406:114
1375:doi
1338:PMC
1330:doi
1271:RET
1083:FAT
773:11Y
590:PDB
556:114
456:PDB
222:cis
92:or
4002::
3894::
3865::
3843::
3813::
3721:,
3701::
3545:,
3541:,
3527:,
3523:,
3519:,
3287:,
3244::
3145:.
3133:28
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