1970:) crystallizer, an idea of Richard Chisum Bennett (a Swenson engineer and later President of Swenson) at the end of the 1950s. The DTB crystallizer (see images) has an internal circulator, typically an axial flow mixer â yellow â pushing upwards in a draft tube while outside the crystallizer there is a settling area in an annulus; in it the exhaust solution moves upwards at a very low velocity, so that large crystals settle â and return to the main circulation â while only the fines, below a given grain size are extracted and eventually destroyed by increasing or decreasing temperature, thus creating additional supersaturation. A quasi-perfect control of all parameters is achieved as DTF crystallizers offer superior control over crystal size and characteristics. This crystallizer, and the derivative models (Krystal, CSC, etc.) could be the ultimate solution if not for a major limitation in the evaporative capacity, due to the limited diameter of the vapor head and the relatively low external circulation not allowing large amounts of energy to be supplied to the system.
895:
1932:, control of the contact time of the crystal mass with the supersaturated solution is achieved, together with reasonable velocities at the exchange surfaces. The Oslo, mentioned above, is a refining of the evaporative forced circulation crystallizer, now equipped with a large crystals settling zone to increase the retention time (usually low in the FC) and to roughly separate heavy slurry zones from clear liquid. Evaporative crystallizers tend to yield larger average crystal size and narrows the crystal size distribution curve.
1287:
crystallization is attributable to fluid shear, the other due to collisions between already existing crystals with either a solid surface of the crystallizer or with other crystals themselves. Fluid-shear nucleation occurs when liquid travels across a crystal at a high speed, sweeping away nuclei that would otherwise be incorporated into a crystal, causing the swept-away nuclei to become new crystals. Contact nucleation has been found to be the most effective and common method for nucleation. The benefits include the following:
1127:
not influenced in any way by solids. These solids include the walls of the crystallizer vessel and particles of any foreign substance. The second category, then, is heterogeneous nucleation. This occurs when solid particles of foreign substances cause an increase in the rate of nucleation that would otherwise not be seen without the existence of these foreign particles. Homogeneous nucleation rarely occurs in practice due to the high energy necessary to begin nucleation without a solid surface to catalyze the nucleation.
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84:
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879:. Tank crystallization is an old method still used in some specialized cases. Saturated solutions, in tank crystallization, are allowed to cool in open tanks. After a period of time the mother liquor is drained and the crystals removed. Nucleation and size of crystals are difficult to control. Typically, labor costs are very high.
1949:
597:
1960:
it is important to control the retention time and the crystal mass, to obtain the optimum conditions in terms of crystal specific surface and the fastest possible growth. This is achieved by a separation â to put it simply â of the crystals from the liquid mass, in order to manage the two flows in a
1829:
conveyor or some hollow discs, in which a refrigerating fluid is circulated, plunge during rotation on a longitudinal axis. The refrigerating fluid is sometimes also circulated in a jacket around the trough. Crystals precipitate on the cold surfaces of the screw/discs, from which they are removed by
1604:
The appearance and size range of a crystalline product is extremely important in crystallization. If further processing of the crystals is desired, large crystals with uniform size are important for washing, filtering, transportation, and storage, because large crystals are easier to filter out of a
1126:
Primary nucleation is the initial formation of a crystal where there are no other crystals present or where, if there are crystals present in the system, they do not have any influence on the process. This can occur in two conditions. The first is homogeneous nucleation, which is nucleation that is
816:
A typical laboratory technique for crystal formation is to dissolve the solid in a solution in which it is partially soluble, usually at high temperatures to obtain supersaturation. The hot mixture is then filtered to remove any insoluble impurities. The filtrate is allowed to slowly cool. Crystals
639:
start to gather into clusters, on the microscopic scale (elevating solute concentration in a small region), that become stable under the current operating conditions. These stable clusters constitute the nuclei. Therefore, the clusters need to reach a critical size in order to become stable nuclei.
1065:
Regarding crystals, there are no exceptions to this rule. Similarly, when the molten crystal is cooled, the molecules will return to their crystalline form once the temperature falls beyond the turning point. This is because the thermal randomization of the surroundings compensates for the loss of
1762:
Many solutes precipitate in hydrate form at low temperatures: in the previous example this is acceptable, and even useful, but it may be detrimental when, for example, the mass of water of hydration to reach a stable hydrate crystallization form is more than the available water: a single block of
1609:
which contains impurities, and a smaller loss of yield when the crystals are washed to remove the mother liquor. In special cases, for example during drug manufacturing in the pharmaceutical industry, small crystal sizes are often desired to improve drug dissolution rate and bio-availability. The
1473:
of solute touching â or adjacent to â the crystal so that it increases its own dimension in successive layers. The pattern of growth resembles the rings of an onion, as shown in the picture, where each colour indicates the same mass of solute; this mass creates increasingly thin layers due to the
1117:
Nucleation is the initiation of a phase change in a small region, such as the formation of a solid crystal from a liquid solution. It is a consequence of rapid local fluctuations on a molecular scale in a homogeneous phase that is in a state of metastable equilibrium. Total nucleation is the sum
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The nature of a crystallization process is governed by both thermodynamic and kinetic factors, which can make it highly variable and difficult to control. Factors such as impurity level, mixing regime, vessel design, and cooling profile can have a major impact on the size, number, and shape of
691:
state and crystal polymorphs of the same compound exhibit different physical properties, such as dissolution rate, shape (angles between facets and facet growth rates), melting point, etc. For this reason, polymorphism is of major importance in industrial manufacture of crystalline products.
1286:
Secondary nucleation is the formation of nuclei attributable to the influence of the existing microscopic crystals in the magma. More simply put, secondary nucleation is when crystal growth is initiated with contact of other existing crystals or "seeds". The first type of known secondary
1880:
Another option is to obtain, at an approximately constant temperature, the precipitation of the crystals by increasing the solute concentration above the solubility threshold. To obtain this, the solute/solvent mass ratio is increased using the technique of
1098:
conditions, may then take place at a concentration higher than the theoretical solubility level. The difference between the actual value of the solute concentration at the crystallization limit and the theoretical (static) solubility threshold is called
663:
is the subsequent size increase of the nuclei that succeed in achieving the critical cluster size. Crystal growth is a dynamic process occurring in equilibrium where solute molecules or atoms precipitate out of solution, and dissolve back into solution.
532:, which is the increase in the size of particles and leads to a crystal state. An important feature of this step is that loose particles form layers at the crystal's surface and lodge themselves into open inconsistencies such as pores, cracks, etc.
1451:
1751:), the precipitation of a mass of sulfate occurs corresponding to the change in solubility from 29% (equilibrium value at 30 °C) to approximately 4.5% (at 0 °C) â actually a larger crystal mass is precipitated, since sulfate entrains
656:â note that "crystal structure" is a special term that refers to the relative arrangement of the atoms or molecules, not the macroscopic properties of the crystal (size and shape), although those are a result of the internal crystal structure.
921:, when heated by an external source, will become liquid. This occurs at a sharply defined temperature (different for each type of crystal). As it liquifies, the complicated architecture of the crystal collapses. Melting occurs because the
1016:
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For biological molecules in which the solvent channels continue to be present to retain the three dimensional structure intact, microbatch crystallization under oil and vapor diffusion methods have been the common methods.
604:
1965:
to be able to extract (and possibly recycle separately) the (almost) clear liquid, while managing the mass flow around the crystallizer to obtain a precise slurry density elsewhere. A typical example is the DTB
1410:
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for internal circulation, where temperature decrease is obtained by heat exchange with an intermediate fluid circulating in a jacket. These simple machines are used in batch processes, as in processing of
601:
1221:
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in the last crystallization stage downstream of vacuum pans, prior to centrifugation. The massecuite enters the crystallizers at the top, and cooling water is pumped through pipes in counterflow.
1747:, it is clear that sulfate solubility quickly decreases below 32.5 °C. Assuming a saturated solution at 30 °C, by cooling it to 0 °C (note that this is possible thanks to the
1078:
As mentioned above, a crystal is formed following a well-defined pattern, or structure, dictated by forces acting at the molecular level. As a consequence, during its formation process the
2563:
2568:
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theoretical crystal size distribution can be estimated as a function of operating conditions with a fairly complicated mathematical process called population balance theory (using
555:, are often difficult to crystallize. The ease with which molecules will crystallize strongly depends on the intensity of either atomic forces (in the case of mineral substances),
806:
Crystal formation can be achieved by various methods, such as: cooling, evaporation, addition of a second solvent to reduce the solubility of the solute (technique known as
1605:
solution than small crystals. Also, larger crystals have a smaller surface area to volume ratio, leading to a higher purity. This higher purity is due to less retention of
1792:
solubility, a term to indicate that solubility increases with temperature decrease (an example occurs with sodium sulfate where solubility is reversed above 32.5 °C).
1530:
The first value is a consequence of the physical characteristics of the solution, while the others define a difference between a well- and poorly designed crystallizer.
813:
The formation of a supersaturated solution does not guarantee crystal formation, and often a seed crystal or scratching the glass is required to form nucleation sites.
687:, it is kinetically stable and requires some input of energy to initiate a transformation to the equilibrium phase. Each polymorph is in fact a different thermodynamic
910:. Whereas most processes that yield more orderly results are achieved by applying heat, crystals usually form at lower temperatures – especially by
2675:
2429:
943:
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Jancic, S. J.; Grootscholten, P.A.M.: âIndustrial
Crystallizationâ, Textbook, Delft University Press and Reidel Publishing Company, Delft, The Netherlands, 1984.
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600:
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entropy that results from the reordering of molecules within the system. Such liquids that crystallize on cooling are the exception rather than the rule.
914:. However, due to the release of the heat of fusion during crystallization, the entropy of the universe increases, thus this principle remains unaltered.
259:
441:
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Glynn P.D. and
Reardon E.J. (1990) "Solid-solution aqueous-solution equilibria: thermodynamic theory and representation". Amer. J. Sci. 290, 164â201.
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2091:
Lin, Yibin (2008). "An
Extensive Study of Protein Phase Diagram Modification:Increasing Macromolecular Crystallizability by Temperature Screening".
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Crystal formation can be divided into two types, where the first type of crystals are composed of a cation and anion, also known as a salt, such as
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3244:
2005:
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370:
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crystallizer is a model, specifically conceived by
Swenson Co. around 1920, having a semicylindric horizontal hollow trough in which a hollow
902:
magnification series for a snow crystal. The crystals are captured, stored, and sputter-coated with platinum at cryo-temperatures for imaging.
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Maximum supersaturation will take place in the coldest points. These may be the heat exchanger tubes which are sensitive to scaling, and
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Additionally, crystal phases can sometimes be interconverted by varying factors such as temperature, such as in the transformation of
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Flow pattern, again as an index of the probability of a molecule of solute to come into contact with an existing crystal (higher in
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70:
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Chayen, Blow (1992). "Microbatch crystallization under oil â a new technique allowing many small-volume crystallization trials".
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expressed in kg/(m*h), and is a constant specific to the process. Growth rate is influenced by several physical factors, such as
676:
148:
56:
31:
2339:
1941:
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and are prone to scaling. Batch processes normally provide a relatively variable quality of the product along with the batch.
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units, whose production accounts for more than 50% of the total world production of crystals. The most common type is the
434:
309:
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Once the first small crystal, the nucleus, forms it acts as a convergence point (if unstable due to supersaturation) for
668:
is one of the driving forces of crystallization, as the solubility of a species is an equilibrium process quantified by K
2596:
2015:
899:
672:. Depending upon the conditions, either nucleation or growth may be predominant over the other, dictating crystal size.
390:
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2858:
885:: MSMPR is used for much larger scale inorganic crystallization. MSMPR can crystalize solutions in a continuous manner.
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scrapers and settle on the bottom of the trough. The screw, if provided, pushes the slurry towards a discharge port.
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Retention time, as an index of the probability of a molecule of solute to come into contact with an existing crystal;
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1731:
crystals in a steel form well above 1000 °C. An example of this crystallization process is the production of
894:
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Many compounds have the ability to crystallize with some having different crystal structures, a phenomenon called
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1748:
684:
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181:
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2703:
3621:
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2484:
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427:
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Total crystal surface in unit fluid mass, as an index of the capability of the solute to fix onto the crystal;
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that form are then filtered and washed with a solvent in which they are not soluble, but is miscible with the
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Low kinetic order and rate-proportional to supersaturation, allowing easy control without unstable operation.
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molecules crystallize easily, and the resulting crystals are generally of good quality, i.e. without visible
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2030:
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2010:
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So, whenever the conditions are favorable, crystal formation results from simply cooling the solution. Here
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163:
141:
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Geankoplis, C.J. (2003) "Transport
Processes and Separation Process Principles". 4th Ed. Prentice-Hall Inc.
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Low necessary energy at which crystals strike avoids the breaking of existing crystals into new crystals.
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1980:
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increasing surface area of the growing crystal. The supersaturated solute mass the original nucleus may
745:
1885:. This process is insensitive to change in temperature (as long as hydration state remains unchanged).
1664:
This division is not really clear-cut, since hybrid systems exist, where cooling is performed through
810:
or drown-out), solvent layering, sublimation, changing the cation or anion, as well as other methods.
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3189:
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2127:
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Supersaturation value, as an index of the quantity of solute available for the growth of the crystal;
571:
560:
556:
490:
482:
105:
62:
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All considerations on control of crystallization parameters are the same as for the cooling models.
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1801:
375:
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The quantitative fundamentals have already been isolated and are being incorporated into practice.
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3153:
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2020:
821:. The process is then repeated to increase the purity in a technique known as recrystallization.
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355:
2194:
1304:
The following model, although somewhat simplified, is often used to model secondary nucleation:
1086:
reaches a certain critical value, before changing status. Solid formation, impossible below the
1679:. This is not a different process, rather a special application of one (or both) of the above.
648:, etc.). It is at the stage of nucleation that the atoms or molecules arrange in a defined and
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1995:
1985:
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385:
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2135:
2100:
1810:
1764:
1011:{\displaystyle T(S_{\text{liquid}}-S_{\text{solid}})>H_{\text{liquid}}-H_{\text{solid}},}
701:
540:
319:
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1833:
A common practice is to cool the solutions by flash evaporation: when a liquid at a given T
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2923:
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2783:
2637:
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2505:
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1957:
1917:
1897:
1815:
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1483:
1277:
is an empirical exponent that can be as large as 10, but generally ranges between 3 and 4.
1100:
665:
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525:
410:
340:
2407:
2131:
712:
83:
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3234:
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3002:
2713:
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1929:
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796:
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304:
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837:
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crystal. The video covers an area of 2.0 by 1.5 mm and was captured over 7.2 min.
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2065:
1990:
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1606:
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Primary nucleation (both homogeneous and heterogeneous) has been modeled as follows:
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818:
567:
27:
Process by which a solid with a highly organized atomic or molecular structure forms
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1743:
and equilibrium concentration (as mass percent of solute in saturated solution) in
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911:
575:
521:
415:
314:
2155:"Crystallization of soluble proteins in vapor diffusion for x-ray crystallography"
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Most industrial crystallizers are of the evaporative type, such as the very large
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of a solute from the liquid solution to a pure solid crystalline phase occurs. In
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2733:
2060:
2000:
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1858:
1703:
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1543:
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1091:
929:) gain in the system by spatial randomization of the molecules has overcome the
807:
770:
641:
612:
548:
510:
498:
365:
130:
1857:
according to the temperature difference and a quantity of solvent, whose total
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Crystallization is also a chemical solidâliquid separation technique, in which
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3387:
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2898:
2883:
2773:
2708:
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1909:
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In the sugar industry, vertical cooling crystallizers are used to exhaust the
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1087:
763:
759:
680:
621:
608:
517:
283:
1294:
Occurs at low supersaturation, where growth rate is optimal for good quality.
799:. The second type of crystals are composed of uncharged species, for example
631:
which are driven by thermodynamic properties as well as chemical properties.
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1778:
1728:
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1450:
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17:
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water, and this has the side effect of increasing the final concentration.
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1928:
throughout the tank, including the exchange surfaces; by controlling pump
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3439:
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1962:
1869:
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of a solution. Too high a viscosity may give hydraulic problems, and the
1700:
solubility that is, the solubility threshold increases with temperature.
1495:
1487:
1095:
930:
753:
742:
There are many examples of natural process that involve crystallization.
502:
486:
466:
2195:"MSMPR Crystallizer | Practical Solubility Science | Prof Steven Abbott"
497:. Attributes of the resulting crystal depend largely on factors such as
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1901:
1079:
922:
800:
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1440:
is an empirical exponent that can range up to 1.5, but is generally 1,
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3114:
2753:
1921:
1865:. In simple words, the liquid is cooled by evaporating a part of it.
697:
582:, although the result is not amorphous or disordered, but a crystal.
458:
1653:
So one may identify two main families of crystallization processes:
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is an empirical exponent that can range up to 5, but is generally 2.
1940:
1668:, thus obtaining at the same time a concentration of the solution.
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2948:
1947:
1939:
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is the step where the solute molecules or atoms dispersed in the
3138:
3013:
1956:
Whichever the form of the crystallizer, to achieve an effective
1948:
1913:
1854:
1405:{\displaystyle B={\dfrac {dN}{dt}}=k_{1}M_{T}^{j}(c-c^{*})^{b},}
1118:
effect of two categories of nucleation â primary and secondary.
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36:
3564:
List of largest biomedical companies by market capitalization
1809:
The simplest cooling crystallizers are tanks provided with a
1777:
A decrease in temperature usually implies an increase of the
1758:
There are limitations in the use of cooling crystallization:
1233:
is the number of nuclei formed per unit volume per unit time,
1763:
hydrate solute will be formed â this occurs in the case of
719:
are a very well-known example, where subtle differences in
1739:. In the diagram, where equilibrium temperature is on the
1633:
Some of the important factors influencing solubility are:
640:
Such critical size is dictated by many different factors (
619:
The crystallization process consists of two major events,
1961:
different way. The practical way is to perform a gravity
1526:, but the reverse applies to the probability of contact).
786:
crystallization (nearly all types of honey crystallize).
516:
Crystallization occurs in two major steps. The first is
1837:
temperature is transferred in a chamber at a pressure P
1216:{\displaystyle B={\dfrac {dN}{dt}}=k_{n}(c-c^{*})^{n},}
849:
101:
1055:{\displaystyle G_{\text{liquid}}<G_{\text{solid}}.}
520:, the appearance of a crystalline phase from either a
1805:
Vertical cooling crystallizer in a beet sugar factory
1785:
thus created may affect the crystallization dynamics.
1321:
1313:
1147:
1139:
1025:
946:
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3453:
3333:
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3212:
3203:
3162:
3107:
3086:
3051:
2995:
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2610:
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2446:
937:) loss due to breaking the crystal packing forces:
906:The crystallization process appears to violate the
869:
332:
291:
265:
249:
155:. Unsourced material may be challenged and removed.
1404:
1215:
1054:
1010:
2569:Ultravioletâvisible spectroscopy of stereoisomers
1696:, dissolved in most solvents, show the so-called
1103:and is a fundamental factor in crystallization.
1671:A crystallization process often referred to in
883:Mixed-Suspension, Mixed-Product-Removal (MSMPR)
752:Natural (mineral) crystal formation (see also
3029:
2669:
2423:
2233:
2231:
1841:such that the liquid saturation temperature T
870:main industrial processes for crystallization
435:
8:
1572:. Unsourced material may be challenged and
71:Learn how and when to remove these messages
3209:
3036:
3022:
3014:
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2662:
2654:
2430:
2416:
2408:
1505:The main values to control are therefore:
1260:is the solute concentration at saturation,
1254:is the instantaneous solute concentration,
578:. Crystallization is therefore related to
442:
428:
246:
2170:
1861:of vaporization equals the difference in
1788:It is not applicable to compounds having
1592:Learn how and when to remove this message
1393:
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233:Learn how and when to remove this message
215:Learn how and when to remove this message
3069:Competitions and prizes in biotechnology
2217:
2215:
1239:is the number of nuclei per unit volume,
559:(organic and biochemical substances) or
2317:from the original on September 25, 2016
2239:Unit Operations of Chemical Engineering
2083:
1774:may be greatly reduced or discontinued;
477:. Some ways by which crystals form are
2307:"Draft Tube Baffle (DTB) Crystallizer"
2262:from the original on November 27, 2016
2006:Fractional crystallization (chemistry)
1082:is in an environment where the solute
683:, meaning that although it is not in
528:solvent. The second step is known as
7:
3589:
2282:"Submerge Circulating Crystallizers"
1986:Chiral resolution by crystallization
1570:adding citations to reliable sources
153:adding citations to reliable sources
2378:Crystallization Technology Handbook
1271:) is also known as supersaturation,
505:, cooling rate, and in the case of
401:Shaping processes in crystal growth
2353:Arkenbout-de Vroome, Tine (1995).
2286:Thermal Kinetics Engineering, PLLC
908:second principle of thermodynamics
25:
2564:NMR spectroscopy of stereoisomers
52:This article has multiple issues.
3588:
3577:
3576:
3077:
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2602:Diastereomeric recrystallization
2348:Illinois Institute of Technology
2340:"Small Molecule Crystallization"
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836:
257:
129:
82:
41:
32:Crystallization (disambiguation)
3554:Index of biotechnology articles
2355:Melt Crystallization Technology
723:conditions result in different
592:Crystallization § Dynamics
371:Fractional crystallization
140:needs additional citations for
60:or discuss these issues on the
3559:List of biotechnology articles
2046:Recrystallization (metallurgy)
1618:Main crystallization processes
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1181:
976:
950:
574:, crystallization occurs in a
1:
3403:Genetically modified organism
3170:Biotechnology industrial park
2041:Recrystallization (chemistry)
1478:in a time unit is called the
917:The molecules within a pure,
591:
2597:Chiral column chromatography
2140:10.1016/0022-0248(92)90241-A
2016:Laser heated pedestal growth
1612:population balance equations
679:. Certain polymorphs may be
469:are highly organized into a
391:Laser-heated pedestal growth
3393:Environmental biotechnology
2237:McCabe & Smith (2000).
2153:Benvenuti, Mangani (2007).
2093:Crystal Growth & Design
1876:Evaporative crystallization
1707:Solubility of the system Na
1660:Evaporative crystallization
1643:Solvent mixture composition
381:Hydrothermal synthesis
346:BridgmanâStockbarger method
95:to comply with Knowledge's
3648:
2894:Electrostatic precipitator
2559:Chiral derivatizing agents
2440:enantioselective synthesis
2403:Industrial Crystallization
2223:Industrial Crystallization
1853:, the liquid will release
1677:fractional crystallization
1462:
1434:is the suspension density,
1110:
773:process examples include:
748:process examples include:
589:
563:(biochemical substances).
29:
3572:
3075:
3064:Timeline of biotechnology
2934:Rotary vacuum-drum filter
2855:
2225:. Plenum Press, New York.
2120:Journal of Crystal Growth
1892:Evaporative crystallizers
1749:freezing-point depression
685:thermodynamic equilibrium
423:
351:Van Arkelâde Boer process
337:
296:
270:
256:
3420:Microbial biodegradation
3099:Industrial biotechnology
3059:History of biotechnology
2977:Aqueous two-phase system
2799:Liquidâliquid extraction
2485:Supramolecular chirality
2241:. McGraw-Hill, New York.
1735:, a crystalline form of
652:manner that defines the
457:is the process by which
376:Fractional freezing
108:may contain suggestions.
93:may need to be rewritten
3617:Liquid-solid separation
3094:Colors of biotechnology
2874:API oilâwater separator
2744:Dissolved air flotation
2031:Pumpable ice technology
2026:Protein crystallization
2011:Igneous differentiation
1912:). A pumping device (a
1683:Cooling crystallization
1657:Cooling crystallization
1090:threshold at the given
356:Czochralski method
3488:Biomedical engineering
3195:Pharmaceutical company
3175:Biotechnology products
2839:Solid-phase extraction
2221:Tavare, N. S. (1995).
2199:www.stevenabbott.co.uk
2172:10.1038/nprot.2007.198
1953:
1945:
1806:
1720:
1630:
1455:
1406:
1217:
1056:
1012:
903:
739:
728:
616:
333:Methods and technology
3627:Laboratory techniques
2959:Vacuum ceramic filter
2954:Sublimation apparatus
2759:Electrochromatography
2719:Cross-flow filtration
2623:Chiral pool synthesis
2537:Diastereomeric excess
2398:Batch Crystallization
2256:www.reciprocalnet.org
2071:X-ray crystallography
1981:Abnormal grain growth
1968:Draft Tube and Baffle
1951:
1943:
1804:
1797:Cooling crystallizers
1706:
1625:
1453:
1407:
1218:
1057:
1013:
897:
746:Geological time scale
734:
715:
607:
561:intramolecular forces
557:intermolecular forces
3513:Chemical engineering
3376:Reproductive cloning
3240:Hybridoma technology
3190:Human Genome Project
2909:Fractionating column
2704:Acidâbase extraction
2685:Separation processes
2633:Asymmetric catalysis
2618:Asymmetric induction
2376:Mersmann, A. (2001)
1920:) keeps the crystal
1727:is a relative term:
1673:chemical engineering
1566:improve this section
1311:
1282:Secondary nucleation
1137:
1023:
944:
572:chemical engineering
149:improve this article
30:For other uses, see
3398:Genetic engineering
3381:Therapeutic cloning
3361:Bionic architecture
3341:Animal cell culture
3108:Biological concepts
2729:Cyclonic separation
2531:Enantiomeric excess
2132:1992JCrGr.122..176C
1626:Crystallization of
1494:, relative crystal
1425:is a rate constant,
1369:
1248:is a rate constant,
1070:crystals produced.
325:Single crystal
305:Crystal growth
3454:Interdisciplinary
3408:Molecular genetics
3154:Selective breeding
2789:Gravity separation
2628:Chiral auxiliaries
2592:Kinetic resolution
2490:Inherent chirality
2475:-symmetric ligands
2311:Swenson Technology
2021:Micro-pulling-down
1954:
1946:
1906:forced circulation
1807:
1721:
1694:chemical compounds
1631:
1456:
1402:
1355:
1340:
1213:
1166:
1122:Primary nucleation
1052:
1008:
904:
890:Thermodynamic view
877:Tank crystallizers
868:Equipment for the
848:. You can help by
766:, rings formation;
740:
729:
617:
547:. However, larger
396:Micro-pulling-down
3632:Phase transitions
3604:
3603:
3533:Nanobiotechnology
3528:Molecular biology
3329:
3328:
3180:Biotechnology law
3011:
3010:
2929:Rapid sand filter
2824:Recrystallization
2804:Electroextraction
2764:Electrofiltration
2651:
2650:
2587:Recrystallization
2579:Chiral resolution
2252:"Crystallization"
2105:10.1021/cg800698p
1996:Crystal structure
1916:or an axial flow
1602:
1601:
1594:
1534:Size distribution
1498:in the solution,
1339:
1165:
1046:
1033:
1002:
989:
973:
960:
866:
865:
829:Typical equipment
654:crystal structure
605:
489:, or more rarely
452:
451:
386:Kyropoulos method
315:Seed crystal
310:Recrystallization
279:Crystal structure
243:
242:
235:
225:
224:
217:
199:
164:"Crystallization"
123:
122:
97:quality standards
75:
16:(Redirected from
3639:
3592:
3591:
3580:
3579:
3430:Pharmacogenomics
3210:
3204:Basic techniques
3185:Green Revolution
3163:General concepts
3081:
3038:
3031:
3024:
3015:
2861:
2678:
2671:
2664:
2655:
2554:Optical rotation
2499:Chiral molecules
2464:Planar chirality
2432:
2425:
2418:
2409:
2327:
2326:
2324:
2322:
2303:
2297:
2296:
2294:
2292:
2278:
2272:
2271:
2269:
2267:
2248:
2242:
2235:
2226:
2219:
2210:
2209:
2207:
2205:
2191:
2185:
2184:
2174:
2165:(7): 1633â1651.
2159:Nature Protocols
2150:
2144:
2143:
2126:(1â4): 176â180.
2115:
2109:
2108:
2088:
1952:Schematic of DTB
1944:DTB Crystallizer
1936:DTB crystallizer
1908:(FC) model (see
1765:calcium chloride
1597:
1590:
1586:
1583:
1577:
1546:
1538:
1502:, and so forth.
1411:
1409:
1408:
1403:
1398:
1397:
1388:
1387:
1368:
1363:
1354:
1353:
1341:
1338:
1330:
1322:
1222:
1220:
1219:
1214:
1209:
1208:
1199:
1198:
1180:
1179:
1167:
1164:
1156:
1148:
1061:
1059:
1058:
1053:
1048:
1047:
1044:
1035:
1034:
1031:
1017:
1015:
1014:
1009:
1004:
1003:
1000:
991:
990:
987:
975:
974:
971:
962:
961:
958:
898:Low-temperature
861:
858:
840:
833:
771:Human time scale
702:titanium dioxide
606:
551:particles, like
535:The majority of
509:, time of fluid
493:directly from a
461:form, where the
444:
437:
430:
320:Protocrystalline
261:
247:
238:
231:
220:
213:
209:
206:
200:
198:
157:
133:
125:
118:
115:
109:
86:
78:
67:
45:
44:
37:
21:
3647:
3646:
3642:
3641:
3640:
3638:
3637:
3636:
3622:Crystallography
3607:
3606:
3605:
3600:
3568:
3542:
3483:Biopharmacology
3455:
3449:
3325:
3296:Electrophoresis
3291:Kidney dialysis
3281:Crystallization
3259:
3205:
3199:
3158:
3103:
3082:
3073:
3047:
3042:
3012:
3007:
2991:
2969:
2963:
2924:Protein skimmer
2862:
2853:
2849:Ultrafiltration
2829:Reverse osmosis
2809:Microfiltration
2784:Froth flotation
2724:Crystallization
2687:
2682:
2652:
2647:
2638:Organocatalysis
2606:
2573:
2542:
2526:Racemic mixture
2494:
2480:Axial chirality
2474:
2447:Chirality types
2442:
2436:
2394:
2336:
2334:Further reading
2331:
2330:
2320:
2318:
2305:
2304:
2300:
2290:
2288:
2280:
2279:
2275:
2265:
2263:
2250:
2249:
2245:
2236:
2229:
2220:
2213:
2203:
2201:
2193:
2192:
2188:
2152:
2151:
2147:
2117:
2116:
2112:
2090:
2089:
2085:
2080:
2075:
1976:
1958:process control
1938:
1924:in homogeneous
1898:sodium chloride
1894:
1878:
1852:
1849:is lower than T
1848:
1844:
1840:
1836:
1816:pharmaceuticals
1799:
1718:
1714:
1710:
1690:
1685:
1620:
1598:
1587:
1581:
1578:
1563:
1547:
1536:
1500:Reynolds number
1484:surface tension
1467:
1461:
1432:
1424:
1389:
1379:
1345:
1331:
1323:
1309:
1308:
1284:
1246:
1200:
1190:
1171:
1157:
1149:
1135:
1134:
1124:
1115:
1109:
1101:supersaturation
1076:
1039:
1026:
1021:
1020:
995:
982:
966:
953:
942:
941:
919:perfect crystal
892:
862:
856:
853:
846:needs expansion
831:
793:
710:
671:
666:Supersaturation
646:supersaturation
611:of growth of a
596:
594:
588:
507:liquid crystals
455:Crystallization
448:
411:Verneuil method
300:Crystallization
251:Crystallization
239:
228:
227:
226:
221:
210:
204:
201:
158:
156:
146:
134:
119:
113:
110:
100:
87:
46:
42:
35:
28:
23:
22:
15:
12:
11:
5:
3645:
3643:
3635:
3634:
3629:
3624:
3619:
3609:
3608:
3602:
3601:
3599:
3598:
3586:
3573:
3570:
3569:
3567:
3566:
3561:
3556:
3550:
3548:
3544:
3543:
3541:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3473:Bioengineering
3470:
3468:Bioelectronics
3465:
3459:
3457:
3451:
3450:
3448:
3447:
3445:Tissue culture
3442:
3437:
3432:
3427:
3422:
3417:
3412:
3411:
3410:
3405:
3395:
3390:
3385:
3384:
3383:
3378:
3368:
3363:
3358:
3353:
3351:Bioinformatics
3348:
3346:Biofabrication
3343:
3337:
3335:
3331:
3330:
3327:
3326:
3324:
3323:
3318:
3313:
3308:
3303:
3298:
3293:
3288:
3286:Chromatography
3283:
3278:
3273:
3271:Centrifugation
3267:
3265:
3264:Chemical field
3261:
3260:
3258:
3257:
3252:
3247:
3242:
3237:
3235:Flow cytometry
3232:
3227:
3222:
3216:
3214:
3207:
3201:
3200:
3198:
3197:
3192:
3187:
3182:
3177:
3172:
3166:
3164:
3160:
3159:
3157:
3156:
3151:
3146:
3141:
3136:
3131:
3122:
3117:
3111:
3109:
3105:
3104:
3102:
3101:
3096:
3090:
3088:
3084:
3083:
3076:
3074:
3072:
3071:
3066:
3061:
3055:
3053:
3049:
3048:
3043:
3041:
3040:
3033:
3026:
3018:
3009:
3008:
3006:
3005:
3003:Unit operation
2999:
2997:
2993:
2992:
2990:
2989:
2984:
2979:
2973:
2971:
2965:
2964:
2962:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2870:
2868:
2864:
2863:
2856:
2854:
2852:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2816:
2811:
2806:
2801:
2796:
2791:
2786:
2781:
2776:
2771:
2766:
2761:
2756:
2751:
2746:
2741:
2736:
2731:
2726:
2721:
2716:
2714:Chromatography
2711:
2706:
2701:
2695:
2693:
2689:
2688:
2683:
2681:
2680:
2673:
2666:
2658:
2649:
2648:
2646:
2645:
2640:
2635:
2630:
2625:
2620:
2614:
2612:
2608:
2607:
2605:
2604:
2599:
2594:
2589:
2583:
2581:
2575:
2574:
2572:
2571:
2566:
2561:
2556:
2550:
2548:
2544:
2543:
2541:
2540:
2534:
2528:
2523:
2518:
2513:
2508:
2502:
2500:
2496:
2495:
2493:
2492:
2487:
2482:
2477:
2472:
2466:
2461:
2456:
2450:
2448:
2444:
2443:
2437:
2435:
2434:
2427:
2420:
2412:
2406:
2405:
2400:
2393:
2392:External links
2390:
2389:
2388:
2374:
2371:
2368:
2365:
2351:
2335:
2332:
2329:
2328:
2298:
2273:
2243:
2227:
2211:
2186:
2145:
2110:
2082:
2081:
2079:
2076:
2074:
2073:
2068:
2063:
2058:
2056:Single crystal
2053:
2048:
2043:
2038:
2033:
2028:
2023:
2018:
2013:
2008:
2003:
1998:
1993:
1988:
1983:
1977:
1975:
1972:
1937:
1934:
1893:
1890:
1877:
1874:
1850:
1846:
1842:
1838:
1834:
1823:Swenson-Walker
1798:
1795:
1794:
1793:
1786:
1775:
1768:
1737:sodium sulfate
1733:Glauber's salt
1716:
1712:
1708:
1689:
1686:
1684:
1681:
1662:
1661:
1658:
1651:
1650:
1649:Ionic strength
1647:
1644:
1641:
1638:
1628:sodium acetate
1619:
1616:
1600:
1599:
1550:
1548:
1541:
1535:
1532:
1528:
1527:
1524:turbulent flow
1516:
1513:
1510:
1465:Crystal growth
1463:Main article:
1460:
1457:
1454:Crystal growth
1448:
1447:
1441:
1435:
1430:
1426:
1422:
1413:
1412:
1401:
1396:
1392:
1386:
1382:
1378:
1375:
1372:
1367:
1362:
1358:
1352:
1348:
1344:
1337:
1334:
1329:
1326:
1319:
1316:
1302:
1301:
1298:
1295:
1292:
1283:
1280:
1279:
1278:
1272:
1261:
1255:
1249:
1244:
1240:
1234:
1224:
1223:
1212:
1207:
1203:
1197:
1193:
1189:
1186:
1183:
1178:
1174:
1170:
1163:
1160:
1155:
1152:
1145:
1142:
1123:
1120:
1111:Main article:
1108:
1105:
1075:
1072:
1063:
1062:
1051:
1042:
1038:
1029:
1018:
1007:
998:
994:
985:
981:
978:
969:
965:
956:
952:
949:
891:
888:
887:
886:
880:
864:
863:
843:
841:
830:
827:
797:sodium acetate
792:
789:
788:
787:
781:
768:
767:
757:
721:crystal growth
709:
706:
669:
661:crystal growth
628:crystal growth
587:
584:
530:crystal growth
526:supersaturated
450:
449:
447:
446:
439:
432:
424:
421:
420:
419:
418:
413:
408:
406:Skull crucible
403:
398:
393:
388:
383:
378:
373:
368:
363:
358:
353:
348:
343:
335:
334:
330:
329:
328:
327:
322:
317:
312:
307:
302:
294:
293:
289:
288:
287:
286:
281:
276:
268:
267:
263:
262:
254:
253:
241:
240:
223:
222:
137:
135:
128:
121:
120:
90:
88:
81:
76:
50:
49:
47:
40:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3644:
3633:
3630:
3628:
3625:
3623:
3620:
3618:
3615:
3614:
3612:
3597:
3596:
3587:
3585:
3584:
3575:
3574:
3571:
3565:
3562:
3560:
3557:
3555:
3552:
3551:
3549:
3545:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3460:
3458:
3452:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3409:
3406:
3404:
3401:
3400:
3399:
3396:
3394:
3391:
3389:
3386:
3382:
3379:
3377:
3374:
3373:
3372:
3369:
3367:
3366:Cell immunity
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3347:
3344:
3342:
3339:
3338:
3336:
3332:
3322:
3321:Sedimentation
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3297:
3294:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3268:
3266:
3262:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3236:
3233:
3231:
3230:Cultured meat
3228:
3226:
3223:
3221:
3218:
3217:
3215:
3213:Biology field
3211:
3208:
3202:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3167:
3165:
3161:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3126:
3123:
3121:
3118:
3116:
3113:
3112:
3110:
3106:
3100:
3097:
3095:
3092:
3091:
3089:
3085:
3080:
3070:
3067:
3065:
3062:
3060:
3057:
3056:
3054:
3050:
3046:
3045:Biotechnology
3039:
3034:
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3027:
3025:
3020:
3019:
3016:
3004:
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3000:
2998:
2994:
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2978:
2975:
2974:
2972:
2966:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2944:Spinning cone
2942:
2940:
2937:
2935:
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2927:
2925:
2922:
2920:
2919:Mixer-settler
2917:
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2912:
2910:
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2895:
2892:
2890:
2887:
2885:
2882:
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2872:
2871:
2869:
2865:
2860:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2834:Sedimentation
2832:
2830:
2827:
2825:
2822:
2820:
2819:Precipitation
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2790:
2787:
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2521:Meso compound
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2396:
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2391:
2387:
2386:0-8247-0528-9
2383:
2380:CRC; 2nd ed.
2379:
2375:
2372:
2369:
2366:
2364:
2363:1-56676-181-6
2360:
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2224:
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2190:
2187:
2182:
2178:
2173:
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2164:
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2156:
2149:
2146:
2141:
2137:
2133:
2129:
2125:
2121:
2114:
2111:
2106:
2102:
2098:
2094:
2087:
2084:
2077:
2072:
2069:
2067:
2066:Vitrification
2064:
2062:
2059:
2057:
2054:
2052:
2049:
2047:
2044:
2042:
2039:
2037:
2034:
2032:
2029:
2027:
2024:
2022:
2019:
2017:
2014:
2012:
2009:
2007:
2004:
2002:
1999:
1997:
1994:
1992:
1991:Crystal habit
1989:
1987:
1984:
1982:
1979:
1978:
1973:
1971:
1969:
1964:
1959:
1950:
1942:
1935:
1933:
1931:
1927:
1923:
1919:
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1911:
1907:
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1891:
1889:
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1875:
1873:
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1860:
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1824:
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1773:
1772:heat exchange
1769:
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1637:Concentration
1636:
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1634:
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1607:mother liquor
1596:
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1575:
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1567:
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1560:
1556:
1551:This section
1549:
1545:
1540:
1539:
1533:
1531:
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1521:
1517:
1514:
1511:
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1506:
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1489:
1486:of solution,
1485:
1481:
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1472:
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1458:
1452:
1445:
1442:
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1433:
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1195:
1191:
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1153:
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1132:
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1128:
1121:
1119:
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1104:
1102:
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1093:
1089:
1085:
1084:concentration
1081:
1073:
1071:
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1019:
1005:
996:
992:
983:
979:
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924:
920:
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896:
889:
884:
881:
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875:
874:
873:
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851:
847:
844:This section
842:
839:
835:
834:
828:
826:
822:
820:
819:mother liquor
814:
811:
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804:
802:
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790:
785:
782:
779:
776:
775:
774:
772:
765:
761:
758:
755:
751:
750:
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747:
743:
738:
735:Crystallized
733:
726:
722:
718:
714:
707:
705:
703:
699:
695:
690:
686:
682:
678:
673:
667:
662:
657:
655:
651:
647:
643:
638:
634:
630:
629:
624:
623:
614:
610:
593:
585:
583:
581:
580:precipitation
577:
573:
569:
568:mass transfer
564:
562:
558:
554:
550:
546:
542:
538:
533:
531:
527:
523:
519:
514:
512:
508:
504:
500:
496:
492:
488:
484:
480:
479:precipitating
476:
472:
468:
464:
460:
456:
445:
440:
438:
433:
431:
426:
425:
422:
417:
414:
412:
409:
407:
404:
402:
399:
397:
394:
392:
389:
387:
384:
382:
379:
377:
374:
372:
369:
367:
364:
362:
359:
357:
354:
352:
349:
347:
344:
342:
339:
338:
336:
331:
326:
323:
321:
318:
316:
313:
311:
308:
306:
303:
301:
298:
297:
295:
290:
285:
282:
280:
277:
275:
272:
271:
269:
264:
260:
255:
252:
248:
245:
237:
234:
219:
216:
208:
197:
194:
190:
187:
183:
180:
176:
173:
169:
166: â
165:
161:
160:Find sources:
154:
150:
144:
143:
138:This article
136:
132:
127:
126:
117:
107:
103:
98:
94:
91:This article
89:
85:
80:
79:
74:
72:
65:
64:
59:
58:
53:
48:
39:
38:
33:
19:
3593:
3581:
3518:Microbiology
3503:Biochemicals
3415:Gene therapy
3356:Biosynthesis
3334:Applications
3280:
3255:Spectroscopy
3225:Cell culture
3134:Fermentation
2904:Filter press
2889:Depth filter
2779:Flocculation
2749:Distillation
2723:
2643:Biocatalysis
2516:Diastereomer
2506:Stereoisomer
2469:
2459:Stereocenter
2438:Concepts in
2377:
2354:
2321:November 15,
2319:. Retrieved
2310:
2301:
2289:. Retrieved
2285:
2276:
2264:. Retrieved
2255:
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2222:
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2198:
2189:
2162:
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2148:
2123:
2119:
2113:
2099:(12): 4277.
2096:
2092:
2086:
2051:Seed crystal
2036:Quasicrystal
1967:
1955:
1905:
1895:
1887:
1879:
1867:
1832:
1822:
1820:
1808:
1789:
1783:laminar flow
1757:
1724:
1722:
1697:
1691:
1670:
1663:
1652:
1632:
1603:
1588:
1579:
1564:Please help
1552:
1529:
1520:laminar flow
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1475:
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1129:
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934:
926:
918:
916:
912:supercooling
905:
882:
876:
867:
854:
850:adding to it
845:
823:
815:
812:
805:
794:
769:
744:
741:
720:
677:polymorphism
674:
660:
658:
632:
626:
620:
618:
576:crystallizer
565:
534:
524:liquid or a
515:
454:
453:
416:Zone melting
299:
266:Fundamentals
250:
244:
229:
211:
205:October 2021
202:
192:
185:
178:
171:
159:
147:Please help
142:verification
139:
114:October 2021
111:
102:You can help
92:
68:
61:
55:
54:Please help
51:
18:Crystallized
3508:Biorobotics
3498:Biomimetics
3493:Biomedicine
2879:Belt filter
2844:Sublimation
2734:Decantation
2061:Symplectite
2001:Crystallite
1883:evaporation
1859:latent heat
1688:Application
1666:evaporation
1640:Temperature
1522:, lower in
1492:temperature
1480:growth rate
1092:temperature
808:antisolvent
778:Snow flakes
642:temperature
613:citric acid
549:biochemical
522:supercooled
511:evaporation
499:temperature
473:known as a
366:Flux method
3611:Categories
3463:Bioeconomy
3435:Stem cells
3388:Embryology
3311:Filtration
3301:Extraction
3220:Bioreactor
2968:Multiphase
2899:Evaporator
2884:Centrifuge
2774:Filtration
2769:Extraction
2709:Adsorption
2699:Absorption
2511:Enantiomer
2291:January 3,
2266:January 3,
2078:References
1926:suspension
1910:evaporator
1113:Nucleation
1107:Nucleation
1088:solubility
857:March 2023
780:formation;
764:stalagmite
760:Stalactite
725:geometries
717:Snowflakes
700:phases of
681:metastable
633:Nucleation
622:nucleation
609:Time-lapse
590:See also:
518:nucleation
491:deposition
284:Nucleation
175:newspapers
57:improve it
3306:Fed Batch
3206:and tools
2982:Azeotrope
2692:Processes
2611:Reactions
2454:Chirality
1779:viscosity
1753:hydration
1729:austenite
1582:July 2017
1553:does not
1471:molecules
1385:∗
1377:−
1196:∗
1188:−
993:−
964:−
708:In nature
471:structure
467:molecules
106:talk page
63:talk page
3583:Category
3538:Virology
3440:Telomere
3087:Branches
2996:Concepts
2987:Eutectic
2939:Scrubber
2914:Leachate
2794:Leaching
2739:Dialysis
2547:Analysis
2315:Archived
2260:Archived
2181:17641629
1974:See also
1963:settling
1870:molasses
1863:enthalpy
1646:Polarity
1496:velocity
1488:pressure
1096:pressure
1074:Dynamics
931:enthalpy
754:gemstone
650:periodic
553:proteins
537:minerals
503:pressure
487:freezing
483:solution
292:Concepts
3595:Commons
3478:Biology
3371:Cloning
3149:Protein
3144:Plasmid
3052:History
2970:systems
2867:Devices
2814:Osmosis
2350:website
2204:May 25,
2128:Bibcode
1902:sucrose
1790:reverse
1725:cooling
1675:is the
1574:removed
1559:sources
1476:capture
1080:crystal
923:entropy
801:menthol
791:Methods
694:anatase
637:solvent
586:Process
545:defects
541:organic
481:from a
475:crystal
361:Epitaxy
274:Crystal
189:scholar
3523:Mining
3456:fields
3115:Allele
2754:Drying
2384:
2361:
2179:
1922:slurry
1745:y-axis
1741:x-axis
1698:direct
1459:Growth
1415:where
1226:where
1032:liquid
988:liquid
959:liquid
698:rutile
501:, air
459:solids
341:Boules
191:
184:
177:
170:
162:
104:. The
3547:Lists
3425:Omics
2949:Still
2346:) at
1918:mixer
1827:screw
1811:mixer
1692:Most
1045:solid
1001:solid
972:solid
784:Honey
737:honey
689:solid
463:atoms
196:JSTOR
182:books
3276:CSTR
3245:HPLC
3139:Gene
3120:Cell
2539:(de)
2533:(ee)
2382:ISBN
2359:ISBN
2357:CRC
2323:2023
2293:2017
2268:2017
2206:2024
2177:PMID
1930:flow
1914:pump
1900:and
1855:heat
1845:at P
1821:The
1557:any
1555:cite
1094:and
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980:>
659:The
625:and
539:and
168:news
3316:PFR
3250:NMR
3129:RNA
3125:DNA
2344:PDF
2167:doi
2136:doi
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696:to
495:gas
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