Docetaxel - Knowledge (XXG)

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administered to pregnant animals causes a variety of embryofetal toxicities, including death, when given during the period of organogenesis. Yet adequate studies investigating maternal and fetal effects in humans are lacking. One small systematic review that examined the use of taxanes to treat breast cancer in pregnancy showed that, out of 19 patients, only three congenital malformations occurred. Two cases of cerebral ventriculomegaly observed in the study were documented prior to the administration of chemotherapy, suggesting an alternate cause of congenital malformation. The third case involved pyloric stenosis in an infant whose mother received a combination regimen of docetaxel, doxorubicin, cyclophosphamide and paclitaxel; because the fetus was exposed to multiple drugs in utero, it remains difficult to identify docetaxel as the causative teratogenic agent. Further studies are needed to better assess the safety of docetaxel in pregnancy and determine appropriate dosing in pregnant women.

1142:. The solution is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL. 20 mg Taxotere is distributed in a blister carton containing one single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL sterile pyrogen-free anhydrous polysorbate 80, and a single dose Taxotere solvent vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose for administration. 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and solvent vials are combined to give a solution of 10 mg/mL and the required dose is drawn from this solution. Vials have an overfill to compensate for liquid loss during preparation, foaming, adhesion to vial walls and the dead volume. 20 mg vials may be stored for 24 months below 25 °C away from light and 80 mg vials for 26 months in the same conditions. 1338:. Resistance to paclitaxel or anthracycline doxorubicin does not necessarily indicate resistance to docetaxel. Microtubules formed in the presence of docetaxel are of a larger size than those formed in the presence of paclitaxel, which may result in improved cytotoxic efficacy. Abundant formation of microtubules and the prevention of replication caused by docetaxel leads to apoptosis of tumour cells and is the basis of docetaxel use as a cancer treatment. Docetaxel activity is significantly greater in ovarian and breast tumours than for lung tumours. 1263:(m), AAG and ALB represent alpha1 acid glycoprotein and albumin plasma concentrations (g/L) respectively, and AGE is the patients age (years). HEP12 represents a measure of hepatic dysfunction, affecting clearance of docetaxel. This final model accounted for a modest proportion of patients and identified most of the patients varying from the model (population median of CL = 35.6 L/h) as having hepatic dysfunction, indicating hepatic function as the most unpredictable factor with regards to clearance variability. 585: 562: 833: 914: 51: 1146:

excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the same drug substance in the same concentration as the already approved two-vial formulation. The same grade, quality, and quantity of polysorbate 80 are present in the infusion solution of both formulations. The only difference between these two formulations is the quantity of ethanol.

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the survival benefit has been confirmed. Doxorubicin was combined with docetaxel in one study of 24 patients and resulted in an increased AUC of docetaxel by 50 to 70%, indicating doxorubicin may affect the disposition of docetaxel. Etoposide has also been shown to decrease docetaxel clearance, though patient numbers for this observation have been low.

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pathways relevant to docetaxel. CYP450 and CYP3A show increased expression in response to the use of anticonvulsants and the metabolism of docetaxel metabolite M4 is processed by these CYPs. A corresponding increase in clearance of M4 by 25% is observed in patients taking phenytoin and phenobarbital, common anticonvulsants.

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excretion of docetaxel is minimal. Saliva contributed minimal excretion and no excretion was detected through pulmonary means. The terminal half-life of docetaxel was determined as approximately 86 hours, through prolonged plasma sampling, contrary to the clinically stated terminal half-life of 10–18 hours.

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InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1

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Pre-treatment with corticosteroids has been used to decrease hypersensitivity reactions and oedema in response to docetaxel and has shown no effect on the pharmacokinetics of docetaxel. The efficacy of docetaxel was improved by treatment with oral capecitabine, and after more than 27 months follow-up

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Docetaxel is a cytotoxic chemotherapeutic agent. As with all chemotherapy, adverse effects are common, and many side effects have been documented. Because docetaxel is a cell-cycle-specific agent, it is cytotoxic to all dividing cells in the body. This includes tumour cells as well as hair follicles,

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is thought not to be a significant factor for docetaxel dosage adjustment. Patients with hepatic insufficiency resulting in serum bilirubin greater than the upper limit of normal (ULN) should not be administered docetaxel, though this is not a stated contraindication. Dosage should be reduced by 20%

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Treatment with docetaxel increases survival time in people with certain types of cancer. While some clinical trials show median survival times to be increased by approximately only three months, the range of survival time is large. Many people survive beyond five years with treatment from docetaxel,

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Docetaxel is used in the treatment of various cancers, including breast, lung, prostate, gastric, head and neck, and ovarian cancer. Clinical data have shown docetaxel to have cytotoxic activity against breast, colorectal, lung, ovarian, prostate, liver, renal, gastric, and head and neck cancers and

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Renal impairment is unlikely to affect metabolism or excretion of docetaxel as renal excretion contributes less than 5% of elimination. Limited data is available for docetaxel use in children with dosage between 55 and 75 mg/m. Two paediatric studies have taken place that show a mean clearance

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Docetaxel is administered via a one-hour infusion every three weeks over ten or more cycles. Treatment is given under the supervision of an oncologist. Strict monitoring of blood cell counts, liver function, serum electrolytes, serum creatinine, heart function, oxygen saturation and fluid retention

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As well as inhibiting mitosis, the presence of docetaxel has been found to lead to the phosphorylation of the oncoprotein bcl-2, which leads to apoptosis of cancer cells that had previously blocked the apoptotic inducing mechanism, leading to tumour regression. Enhanced effects of radiation therapy

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Docetaxel exhibits cytotoxic activity on breast, colorectal, lung, ovarian, gastric, renal and prostate cancer cells. Docetaxel does not block disassembly of interphase microtubules and so does not prevent entry into the mitotic cycle, but does block mitosis by inhibiting mitotic spindle assembly.

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reversibly with high affinity and has a maximum stoichiometry of 1 mole docetaxel per mole tubulin in microtubules. This binding stabilizes microtubules and prevents depolymerisation from calcium ions, decreased temperature and dilution, preferentially at the plus end of the microtubule. Docetaxel

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Premedication with corticosteroids is recommended before each administration of docetaxel to reduce fluid retention and hypersensitive reactions. Other medications will often be given to aid pain management and other symptoms. The treatment of breast cancer with doxorubicin and cyclophosphamide is

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Based on the limited data available, docetaxel appears to be safe in pregnancy if administered during the second and third trimesters; however, maternal and fetal risks should be weighed against benefits to determine the appropriate course of action. As with all chemotherapeutic agents, docetaxel

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Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl functional group on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side chain instead of the benzamide in paclitaxel. The carbon 10

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The use of docetaxel during chemotherapy, especially when given weekly, may lead to complications with the lacrimal drainage system. The mechanism for this problem seems to be secretion of docetaxel by the lacrimal gland which can then cause stenosis, or narrowing, of the punctum and canalicular

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Patients with significant hepatic dysfunction had an approximately 30% decrease in clearance of docetaxel and were also at a higher risk of toxicity poisoning from docetaxel treatment. Clearance has been shown from population pharmacokinetic studies to decrease significantly with age, increased

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are all potentially co-administered with docetaxel and did not modify docetaxel plasma binding in phase II studies. Cisplatin is known to have a complex interaction with some CYPs and has in some events been shown to reduce docetaxel clearance by up to 25%. Anticonvulsants induce some metabolic

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Taxane-induced pneumotoxicity is rare. However, 1–5% of patients taking docetaxel may develop severe pneumotoxicity. Patients may develop exertional breathlessness and desaturation which needs to be detected early. Chest X-Ray may show bilateral opacities and High Resolution CT chest may reveal

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Biodistribution of 14C-labelled docetaxel in three patients showed the bulk of the drug to be metabolised and excreted in bile to the faeces. Of the radioactively labelled docetaxel administered, 80% was eliminated to the faeces with 5% in the urine over seven days, an indication that urinary

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The optimal dose scheduling of taxanes remains unconfirmed, but most studies find significant mortality benefit following either a three-week or a one-week administration schedule. While a 2010 article in Current Clinical Pharmacology states, "weekly administration has emerged as the optimal

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Recently Sanofi has got approval for one-vial formulation. With this one-vial formulation, the preparation of the infusion solution is simplified by eliminating the first dilution step. The two-vial and one-vial formulations contain the same drug substance, docetaxel trihydrate, and the same

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subfamilies of isoenzymes. Metabolism is principally oxidative and at the tert-butylpropionate side chain, resulting first in an alcohol docetaxel (M2), which is then cyclised to three further metabolites (M1, M3 and M4). M1 and M3 are two diastereomeric hydroxyoxazolidinones and M4 is an

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includes lipoproteins, alpha1 acid glycoprotein and albumin. Alpha1 acid glycoprotein is the most variable of these proteins inter-individually, especially in cancer patients and is therefore the main determinant of docetaxel's plasma binding variability. Docetaxel interacted little with

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when combined with docetaxel has been observed in mice. Docetaxel has also been found to have greater cellular uptake and is retained longer intracellularly than paclitaxel allowing docetaxel treatment to be effective with a smaller dose, leading to fewer and less severe adverse effects.

1195:, bioavailability increased to 90% ± 44%. In practice, docetaxel is administered intravenously only to increase dose precision. Evaluation of docetaxel pharmacokinetics in phase II and III clinical studies were with 100 mg/m dosages given over one-hour infusions every three weeks. 1166:. In this T-shaped/butterfly model, a deep hydrophobic cleft exists near the surface of the β-tubulin where three potential hydrogen bonds and multiple hydrophobic contacts bind to docetaxel. The hydrophobic pocket walls contain helices H1, H6, H7 and a loop between H6 and H7 that form 1230:

had a mean value of 2.8 mg.h/L. The Cmax of docetaxel was found to be 4.15 ± 1.35 mg/L. Increased dose resulted in a linear increase of the area under the concentration-time curve and so it is concluded that dose is directly proportional to plasma concentration.

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of mean 4.5 minutes is representative of distribution to peripheral compartments from the systemic circulation. A β half-life of mean 38.3 minutes and a relatively slow γ half-life of mean 12.2 hours represent the slow efflux of docetaxel from the peripheral compartment.

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analysis show the anti-neoplastic activity of docetaxel to be effective against a wide range of known cancer cells, cooperate with other anti-neoplastic agents activity, and have greater cytotoxicity than paclitaxel, possibly due to its more rapid intracellular uptake.

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has been found to accumulate to higher concentration in ovarian adenocarcinoma cells than kidney carcinoma cells, which may contribute to the more effective treatment of ovarian cancer by docetaxel. It has also been found to lead to the phosphorylation of oncoprotein

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outflow system. In most cases the primary symptoms is epiphora or tearing. When treated early most patients can avoid the need for surgery, but some cases the only cure is a conjunctivodacryocystorhinostomy in which a glass tube is placed to bypass the tear duct.

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occur; sometimes this can be permanent. North west France are conducting a survey to establish exactly how many people are affected in this way. Independent studies show it could be as high as 6.3%, which puts it in the 'common and frequent' classification.

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however it is difficult to attribute these findings directly to treatment with docetaxel. Improved median survival time and response indicates that docetaxel slows metastatic cancer progression and can lead to disease-free survival. Conjunctive treatment of

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Docetaxel is contraindicated for use with patients with a baseline neutrophil count less than 1500 cells/μL, a history of severe hypersensitivity reactions to docetaxel or polysorbate 80, severe liver impairment and pregnant or breast-feeding women.

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Organizing Pneumonia (OP) pattern or Non-Specific Organizing Pneumonia (NSIP) pattern or a combination. Docetaxel-induced DPLD is a fatal adverse effect, which can be managed by the cessation of the drug and starting on steroids in adequate doses.

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Incidence of commonly experienced non-haematological adverse effects reported for treatment with docetaxel. Data from 40 phase II and phase III studies (n = 2045) with patients undergoing a one-hour infusion of 100 mg/m docetaxel once every three

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Docetaxel and paclitaxel have comparable efficacy metastatic breast cancer but paclitaxel has less severe side effects. Additionally, it has been noted that docetaxel is prone to cellular drug resistance via a variety of different mechanisms.

1122:. Due to scarcity of paclitaxel, extensive research was carried out leading to the formulation of docetaxel – an esterified product of 10-deacetyl baccatin III, which is extracted from the renewable and more readily available leaves of the 1251:

oxazolidinedione. Phase II trials of 577 patients showed docetaxel clearance is related to body surface area and to hepatic enzyme and alpha1 acid glycoprotein plasma levels. The following model represents docetaxel clearance in humans:

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of 33 L/h/m and concentration-time profiles best fitted by a two-compartmental model of distribution and elimination. Mean distribution half-life was 0.09 hours and mean elimination half-life was 1.4 hours in paediatric studies.

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Because microtubules do not disassemble in the presence of docetaxel, they accumulate inside the cell and cause initiation of apoptosis. Apoptosis is also encouraged by the blocking of apoptosis-blocking bcl-2 oncoprotein. Both

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Qi WX, Shen Z, Lin F, Sun YJ, Min DL, Tang LN, et al. (February 2013). "Paclitaxel-based versus docetaxel-based regimens in metastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials".

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Erythromycin, ketoconazole and cyclosporine are CYP3A4 inhibitors and therefore inhibit the metabolic pathway of docetaxel. When used with anticonvulsants, which induce CYP3A4, an increased dose of docetaxel may be required.

1309:. This leads to a significant decrease in free tubulin, needed for microtubule formation and results in inhibition of mitotic cell division between metaphase and anaphase, preventing further cancer cell progeny. 792:

and future cancers. Docetaxel induced pneumotoxicity is also a well recognized adverse effect which has to be identified timely and treated after withholding the drug. Side effects are more common in people with

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Incidence of severe adverse effects reported in patients treated with docetaxel. Data from 40 phase II and phase III studies with patients undergoing a one-hour infusion of 100 mg/m docetaxel once every three

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The main mode of therapeutic action of docetaxel is the suppression of microtubule dynamic assembly and disassembly, rather than microtubule bundling leading to apoptosis, or the blocking of bcl-2.

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in people who develop grade 3 or 4 diarrhea following exposure to docetaxel, hepatotoxicity defined by liver enzymes at levels greater than five times the ULN, and grade 2 palmer-planter toxicity.

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The cytotoxic activity of docetaxel is exerted by promoting and stabilising microtubule assembly, while preventing physiological microtubule depolymerisation/disassembly in the absence of

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Guitton J, Cohen S, Tranchand B, et al. (2005). "Quantification of docetaxel and its main metabolites in human plasma by liquid chromatography/tandem mass spectrometry".

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with the 3’-benzamido phenyl, 3’-phenyl, and the 2-benzoyl phenyl of docetaxel. 3’-phenyl also has contact with β-sheets B8 and B10. The C-8 methyl of docetaxel has

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and was unaffected by the polysorbate 80 in its storage medium. Polysorbate 80 may be the cause of hypersensitivity reasons in taxanes as recent studies indicated.

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Docetaxel is a white powder and is the active ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in

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The concentration-time profile of docetaxel was consistent with a three-compartment pharmacokinetic model. An initial, relatively rapid decline, with an α

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Urien S, Barré J, Morin C, Paccaly A, Montay G, Tillement JP (1996). "Docetaxel serum protein binding with high affinity to alpha 1-acid glycoprotein".

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with docetaxel has been shown to lead to improved survival rate as well as improved quality of life and reduction of pain compared with treatments with

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Denisenko TV, Sorokina IV, Gogvadze V, Zhivotovsky B (January 2016). "Mitotic catastrophe and cancer drug resistance: A link that must to be broken".

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Prednisone given with docetaxel led to improved survival, quality of life and pain management in patients with hormone-refractory prostate cancer.

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Gideon Koren, Nathalie Carey, Robert Gagnon, et al. Cancer Chemotherapy and Pregnancy, "Journal of Obstetrics and Gynecology Canada", March 2013

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Esmaeli B, Valero V, Ahmadi MA, Booser D (May 2001). "Canalicular stenosis secondary to docetaxel (taxotere): a newly recognized side effect".

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In the UK (in 2009) The cost of six cycles (18 weeks) of docetaxel at a dose of 75 mg/m2 IV every 21 days is £5,262 (based on an average

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Many more side effects have been reported for conjunctive and adjuvant treatment with docetaxel as well as rare post-marketing events.

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Shelley M, Harrison C, Coles B, Staffurth J, Wilt TJ, Mason MD (October 2006). "Chemotherapy for hormone-refractory prostate cancer".

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Increased risk of docetaxel toxicity including some or all of the following: anaemia, leucopoenia, thrombocytopenia, fever, diarrhoea

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enhanced by adjuvant treatment with docetaxel. Docetaxel is also used in combination with capecitabine, a DNA synthesis inhibitor.

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Administration a 100 mg/m dose over a one-hour infusion gave a mean total body clearance of 21 L/h/m and a mean steady state

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Docetaxel was shown to be greater than 98% plasma protein bound independent of concentration at 37 °C and pH 7.4 Docetaxel's

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are placed on her hands and feet to prevent deleterious effects on the nails. Similar strategies can be used to prevent hair loss.

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Paediatric trials of docetaxel have been limited, and so safety of use in patients under 16 years has not been established.

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Eisenhauer EA, Vermorken JB (January 1998). "The taxoids. Comparative clinical pharmacology and therapeutic potential".

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Drug interactions may be the result of altered pharmacokinetics or pharmacodynamics due to one of the drugs involved.

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Side effects are experienced more frequently by patients of 65 years or older, but dosage is usually not decreased.

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as well as Docefrez by Sun Pharma Global and Zytax by Zydus. Annual sales of Taxotere in 2010 were €2.122 billion (

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of Calmette and Guerin, measles, mumps, poliovirus, rotavirus, rubella, smallpox, typhoid, varicella, yellow fever

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Cyclosporine, dalfopristin, erythromycin, itraconazole, ketoconazole, quinupristin, terfenadine, troleandomycin

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is required detect adverse reactions and toxicity so that treatment can be modified or terminated if necessary.

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melanoma. In hormone-refractory prostate cancer docetaxel improves life expectancy and overall life quality.

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with two residues, Thr-276 and Gln-281 near the C-terminal end of β-tubulin. Docetaxel's O-21 experiences

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O=C(OC(C)(C)C)N(c1ccccc1)(O)C(=O)O4C(=C3/(O)C(=O)6(((OC(=O)c2ccccc2)(O)(C3(C)C)C4)5(OC(=O)C)(OC5)C6O)C)/C

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Observations of severe side effects in the above 40 phase II and phase III studies were also recorded.

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Docetaxel was developed by Rhône-Poulenc Rorer (now Sanofi-Aventis) following from the discoveries of

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Lyseng-Williamson KA, Fenton C (2005). "Docetaxel: a review of its use in metastatic breast cancer".

1437: 1227: 1211: 1171: 770: 754: 530: 298: 2624:"The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density" 1592: 5884: 5489: 5295: 5195: 5119: 4552: 4452: 4431: 4152: 3974: 3806: 3537: 3433: 1335: 904: 832: 557: 356: 168: 4919: 3050:. National Institute for Health Research, U.K. National Health Service. April 2009. Archived from 1625:

Hettiarachchi SM, Thilakaratne D, Dharmasena D, Rathnapala A, Abeysinghe P, Perera E (July 2021).

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schedule," the official docetaxel package insert recommends administration every three weeks.

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bone marrow and other germ cells. For this reason, common chemotherapy side effects such as

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Oral bioavailability has been found to be 8% ±6% on its own and, when co-administered with

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to Thr-276 and the C-12 methyl has proximity with Leu-371 on the loop between B9 and B10.

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Common and/or likely drug-drug combinations and known side effects from drug interactions

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1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2

286: 266: 4821: 3019: 2830: 2745: 2639: 2078:"Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer" 584: 561: 5783: 5703: 5573: 5430: 5285: 5250: 4909: 4798: 4332: 3923: 3417: 3281: 3168: 3138: 3125: 2722: 2697: 2276: 2249: 1651: 1626: 1371: 1352: 1139: 977: 841: 794: 769:. It may be used by itself or along with other chemotherapy medication. It is given by 758: 2930: 2491: 2474: 2451: 1875: 5868: 5723: 5598: 5483: 5445: 5340: 5305: 5240: 5039: 4999: 4899: 4672: 4632: 4002: 3875: 3756: 3699: 3457: 3406: 2899: 2874: 2658: 2623: 2174: 1972: 1801: 1363: 1267:

alpha1 acid glycoprotein and albumin concentrations and decreased body surface area.

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functional group change causes docetaxel to be more water-soluble than paclitaxel.

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Docetaxel was patented in 1986 and approved for medical use in 1995. It is on the

3069:"TA101 Prostate cancer (hormone-refractory) - docetaxel: analysis of cost impact" 2218: 1566: 1411: 83: 5793: 5763: 5743: 5693: 5568: 5563: 5548: 5518: 5345: 5300: 5260: 5255: 5205: 5200: 5185: 5024: 4984: 4889: 4764: 4744: 4729: 4724: 4709: 4667: 4637: 4577: 4547: 4491: 4464: 4337: 4278: 4250: 4240: 4193: 4157: 4073: 4035: 4017: 4012: 3992: 3969: 3940: 3918: 3898: 3888: 3739: 3724: 3704: 3590: 3521: 3507: 3462: 3395: 3390: 3367: 3342: 3310: 3253: 3216: 3193: 3178: 3173: 3158: 1959:

Clarke SJ, Rivory LP (February 1999). "Clinical pharmacokinetics of docetaxel".

1204: 1018: 1010: 943: 932: 91: 2964: 5773: 5733: 5678: 5668: 5608: 5593: 5578: 5558: 5533: 5528: 5508: 5503: 5460: 5450: 5415: 5390: 5370: 5335: 5314: 5270: 5245: 5029: 4994: 4979: 4974: 4943: 4904: 4884: 4754: 4657: 4652: 4627: 4622: 4612: 4607: 4602: 4572: 4562: 4527: 4522: 4502: 4457: 4445: 4420: 4415: 4405: 4387: 4382: 4372: 4367: 4325: 4313: 4301: 4273: 4260: 4255: 4225: 4188: 4183: 4121: 4116: 4062: 4007: 3959: 3945: 3893: 3880: 3849: 3782: 3771: 3744: 3734: 3729: 3675: 3630: 3625: 3526: 3490: 3422: 3412: 3401: 3385: 3337: 3320: 3296: 3248: 3236: 3188: 2713: 1375: 1113: 863: 627: 441: 5698: 5688: 5683: 5673: 5658: 5643: 5588: 5543: 5513: 5375: 5280: 5220: 5215: 5084: 5014: 5004: 4949: 4769: 4749: 4704: 4694: 4688: 4592: 4537: 4486: 4410: 4400: 4355: 4342: 4283: 4245: 4173: 4111: 4052: 4041: 3997: 3954: 3913: 3907: 3903: 3865: 3792: 3787: 3777: 3749: 3709: 3670: 3645: 3635: 3595: 3241: 3231: 3226: 3183: 2532: 2515: 1014: 1002: 798: 781: 777: 316: 311: 77: 2972: 2908: 2846: 2800: 2731: 2667: 2648: 2541: 2500: 2459: 2355: 2285: 2226: 2103: 1980: 1840: 1809: 1734:

World Health Organization model list of essential medicines: 21st list 2019

1660: 2986: 2597: 2182: 33: 5603: 5583: 5553: 5425: 5385: 5235: 5225: 5099: 4678: 4642: 4582: 4350: 4288: 4068: 3964: 3936: 3615: 3452: 2987:"Docefrez (Docetaxel): Uses, Dosage, Side Effects, Interactions, Warning" 2890: 2473:

Koren G, Carey N, Gagnon R, Maxwell C, Nulman I, Senikas V (March 2013).

2094: 2077: 1255:

CL = BSA · (22.1 − 3.55·AAG − 0.095·AGE + 0.2245·ALB) · (1 − 0.334·HEP12)

924: 421: 119: 2775:"Comparative pharmacokinetics of weekly and every-three-weeks docetaxel" 2266: 1742: 430: 17: 5813: 5798: 5728: 5190: 4914: 3571: 3472: 3286: 3147: 2589: 1163: 1162:

deconvolution has been proposed to explain the binding of docetaxel to

940: 936: 376: 2622:

Snyder JP, Nettles JH, Cornett B, Downing KH, Nogales E (April 2001).

2347: 41: 3211: 2838: 1642: 1247: 1243: 1109: 805:

family of medications. It works by disrupting the normal function of

802: 746: 521: 490: 1857:. U.S. Food and Drug Administration. February 2011. Archived from 1294: 831: 650: 641: 501: 291: 2417:(5th ed.). London: Churchill Livingstone. pp. 694–698. 1367: 1116:(Taxol), an extract from the bark of the rare Pacific yew tree, 481: 242: 4825: 3093: 2379: 2377: 1677:(69 ed.). British Medical Association. 2015. p. 622. 227: 114: 1445: 2385:"Taxotere.com for Healthcare Professionals: Pharmacokinetics" 2129:"Taxotere for Healthcare Professionals: Efficacy and Safety" 2076:

Tannock IF, de Wit R, Berry WR, et al. (October 2004).

1858: 546: 1351:

Docetaxel is marketed worldwide under the name Taxotere by

214: 146: 4864: 1746:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 784:(low blood cell counts), numbness, shortness of breath, 3048:

The National Horizon Scanning Centre Research Programme

1297:, which is apoptosis-blocking in its oncoprotein form. 818:

World Health Organization's List of Essential Medicines

716: 1493:"Taxotere- docetaxel injection, solution, concentrate" 836:

A woman being treated with docetaxel chemotherapy for

788:, and muscle pains. Other severe side effects include 5842: 3016:

French National Centre for Scientific Research (CNRS)

2123: 2121: 2119: 2117: 2115: 2113: 1783: 1781: 1779: 1777: 1775: 1773: 1569:. The American Society of Health-System Pharmacists. 1374:

during his work on improvements to the production of

1259:

where CL is total body clearance (L/h), BSA is total

2773:

Baker SD, Zhao M, Lee CK, et al. (March 2004).

1870: 1868: 1771: 1769: 1767: 1765: 1763: 1761: 1759: 1757: 1755: 1753: 1239:

Docetaxel is mainly metabolised in the liver by the

5118: 4862: 4479: 4430: 4210: 4203: 4139: 4093: 4026: 3983: 3820: 3805: 3685: 3655: 3580: 3565: 3536: 3432: 3352: 3295: 3278: 3267: 3203: 3156: 3137: 2514:Cardonick E, Bhat A, Gilmandyar D, Somer R (2012). 639: 626: 596: 591: 572: 540: 520: 500: 480: 460: 440: 420: 409: 400: 375: 355: 322: 310: 297: 285: 275: 265: 257: 204: 199: 174: 160: 134: 104: 90: 72: 62: 57: 2698:"Safety of Polysorbate 80 in the Oncology Setting" 1058:Cholestatic jaundice and pseudomembranous colitis 3012:"Pierre Potier, chemist, 1998 CNRS Gold Medalist" 2681:New Zealand Pharmaceutical Schedule. Wellington. 389: 364: 2873:Yvon AM, Wadsworth P, Jordan MA (April 1999). 2413:Rang HP, Dale MM, Ritter JM, Moore PK (2003). 2387:. Sanofi-aventis U.S. LLC. 23 September 2006. 1878:. Sanofi-Aventis U.S. LLC. 16 September 2006. 1876:"Taxotere for Healthcare Professionals: About" 1228:Area under the plasma concentration-time curve 5910:World Health Organization essential medicines 4837: 3105: 2553: 2551: 2156: 2154: 2152: 2150: 2040:"Taxotere Docetaxel concentrate for infusion" 1108:Docetaxel is of the chemotherapy drug class; 8: 1620: 1618: 1222:of 73.8 L/m or 123 L based on the mean BSA ( 1078:Increased risk of infection by live vaccine 123: 32: 5120: 2408: 2406: 2034: 2032: 2030: 2028: 2026: 2024: 2022: 2020: 2018: 1825:The Cochrane Database of Systematic Reviews 250:In general: ℞ (Prescription only) 5171:Allopregnanedione (5α-dihydroprogesterone) 4844: 4830: 4822: 4207: 3817: 3577: 3292: 3275: 3153: 3112: 3098: 3090: 2812: 2810: 2307: 2305: 2303: 2301: 2299: 2297: 2295: 2071: 2069: 2067: 2065: 2016: 2014: 2012: 2010: 2008: 2006: 2004: 2002: 2000: 1998: 1954: 1952: 1950: 1948: 1946: 1944: 1942: 1940: 1938: 1936: 1934: 1932: 1930: 1928: 1926: 1924: 1922: 1920: 1918: 1916: 1561: 1559: 1557: 1555: 1553: 1551: 1549: 1547: 1545: 1543: 1359:3.1 billion). The patent expired in 2010. 583: 560: 449: 2898: 2790: 2721: 2657: 2647: 2617: 2615: 2531: 2490: 2275: 2265: 2093: 1914: 1912: 1910: 1908: 1906: 1904: 1902: 1900: 1898: 1896: 1741: 1650: 1086:Increased risk of venous thromboembolism 469: 4869:Tooltip Constitutive androstane receptor 2768: 2766: 2696:Schwartzberg LS, Navari RM (June 2018). 2571: 2569: 2567: 2565: 2563: 1675:British national formulary : BNF 69 1024: 912: 903: 5849: 2868: 2866: 2864: 2862: 2860: 2858: 2856: 1403: 931:Haematological adverse effects include 801:may harm the baby. Docetaxel is in the 690: 670: 556: 429: 336: 96: 5624:Pregnanedione (5β-dihydroprogesterone) 5010:Pregnanedione (5β-dihydroprogesterone) 1704:. John Wiley & Sons. p. 512. 1471:Therapeutic Goods Administration (TGA) 1112:, and is a semi-synthetic analogue of 574: 31: 2135:from the original on 11 November 2006 1736:. Geneva: World Health Organization. 1603:from the original on 21 December 2016 1573:from the original on 21 December 2016 1042:Increased risk of delayed neuropathy 968:Contraindications and patient factors 529: 509: 82: 7: 2332:"Chemotherapy for colorectal cancer" 2207:Current Medical Research and Opinion 187: 3381:ribonucleotide reductase inhibitors 2475:"Cancer chemotherapy and pregnancy" 1347:Discovery, regulation and marketing 1063:Doxorubicin hydrochloride liposome 745:used to treat a number of types of 489: 380: 68:Taxotere, Docecad, Docefrez, others 3547:Ribonucleotide reductase inhibitor 3503:Ribonucleotide reductase inhibitor 2923:"Docetaxel: Clinical Pharmacology" 2248:Alken S, Kelly CM (October 2013). 347:)-3--2-hydroxy-3-phenylpropanoate} 25: 3306:Dihydrofolate reductase inhibitor 1034:Adverse effects from interaction 5852: 3071:. London: NICE. September 2006. 2370:from the original on 2012-10-06. 2313:"Drugdex Evaluations: Docetaxel" 2175:10.2165/00003495-199855010-00002 1973:10.2165/00003088-199936020-00002 1802:10.2165/00003495-200565170-00007 1718:from the original on 2016-12-21. 1412:"Docetaxel Use During Pregnancy" 1031:Drug interacting with docetaxel 614: 608: 49: 40: 3075:from the original on 2009-03-21 2993:from the original on 2014-05-12 2752:from the original on 2015-07-01 2391:from the original on 2006-11-11 1882:from the original on 2006-11-09 1698:Fischer J, Ganellin CR (2006). 1066:Increased doxorubicin exposure 698:Key:ZDZOTLJHXYCWBA-VCVYQWHSSA-N 5176:Allopregnanolone (brexanolone) 3443:Thymidylate synthase inhibitor 3333:Thymidylate synthase inhibitor 2254:Cancer Management and Research 1833:10.1002/14651858.CD005247.pub2 887:Monitoring and combination use 820:. Docetaxel is available as a 617: 602: 1: 5831:Receptor/signaling modulators 5789:Tropanyl 3,5-dimethulbenzoate 5639:Pregnenolone 16α-carbonitrile 3363:Adenosine deaminase inhibitor 3204:Block microtubule disassembly 2792:10.1158/1078-0432.CCR-0842-03 2492:10.1016/s1701-2163(15)30999-3 2452:10.1016/S0161-6420(00)00640-0 2330:Goyle S, Maraveyas A (2005). 1701:Analogue-based Drug Discovery 1134:Formulations and compositions 737:), sold under the brand name 2685:(Report). 2006. p. 133. 2628:Proc. Natl. Acad. Sci. U.S.A 2219:10.1185/03007995.2012.756393 1593:"FDA Approval for Docetaxel" 776:Common side effects include 5366:Dodecylbenzenesulfonic acid 5125:Tooltip Pregnane X receptor 4853:Xenobiotic-sensing receptor 2819:Rapid Commun. Mass Spectrom 2131:. Sanofi-Aventis U.S. LLC. 1187:Absorption and distribution 5931: 2965:10.1016/j.drup.2015.11.002 1855:"Docetaxel Package Insert" 1172:Van der Waals interactions 1160:nuclear magnetic resonance 1055:Doxorubicin hydrochloride 771:slow injection into a vein 767:non-small-cell lung cancer 592:Chemical and physical data 5822: 4782: 4663:Omacetaxine mepesuccinate 4543:Ciltacabtagene autoleucel 4533:Brexucabtagene autoleucel 2714:10.1007/s12325-018-0707-z 1730:World Health Organization 1597:National Cancer Institute 1524:European Medicines Agency 1156:electron crystallographic 706: 681: 661: 327: 48: 39: 5749:Testosterone isocaproate 5664:Reverse triiodothyronine 4715:Talimogene laherparepvec 4648:Nadofaragene firadenovec 4618:Lisocabtagene maraleucel 3567:Topoisomerase inhibitors 3486:DNA polymerase inhibitor 1631:Respirology Case Reports 1378:(Taxol) using the local 1235:Metabolism and excretion 1176:electrostatic attraction 1168:hydrophobic interactions 5141:17α-Hydroxyprogesterone 5136:17α-Hydroxypregnenolone 4518:Axicabtagene ciloleucel 3122:chemotherapeutic agents 2953:Drug Resistance Updates 743:chemotherapy medication 27:Chemotherapy medication 5890:Microtubule inhibitors 4700:Sitimagene ceradenovec 4598:Idecabtagene vicleucel 4163:Methyl aminolevulinate 2649:10.1073/pnas.051309398 1220:volume of distribution 1200:plasma protein binding 919: 910: 845: 4880:6,7-Dimethylesculetin 4174:Porphyrin derivatives 3870:Melphalan flufenamide 3517:Hypomethylating agent 3126:antineoplastic agents 2533:10.1093/annonc/mds170 2479:J Obstet Gynaecol Can 916: 907: 835: 809:and thereby stopping 5467:Hypericum perforatum 5456:Hetacillin potassium 4503:Asparagine depleters 4432:Receptor antagonists 4346:+abiraterone acetate 3057:on 17 November 2009. 2891:10.1091/mbc.10.4.947 2319:. 26 September 2006. 2095:10.1056/NEJMoa040720 755:head and neck cancer 5296:Cyproterone acetate 5196:Amlodipine besylate 4553:Denileukin diftitox 4453:Retinoid X receptor 4153:Aminolevulinic acid 3975:Triethylenemelamine 3807:Crosslinking of DNA 3538:Deoxyribonucleotide 3477:+gimeracil/oteracil 2831:2005RCMS...19.2419G 2702:Advances in Therapy 2640:2001PNAS...98.5312S 2267:10.2147/CMAR.S49321 1528:. 17 September 2018 1342:Society and culture 1336:mitotic catastrophe 1288:Docetaxel binds to 1279:Mechanism of action 1027: 840:. Cold mittens and 741:among others, is a 223:(Prescription only) 36: 5895:Mitotic inhibitors 5769:Thonzonium bromide 5524:Methylprednisolone 5325:prasterone sulfate 4809:Never to phase III 3611:Etirinotecan pegol 2590:10.1007/BF00210785 2317:Thomson MICROMEDEX 1961:Clin Pharmacokinet 1499:. 26 December 2019 1329:Cellular responses 1025: 920: 911: 846: 822:generic medication 790:allergic reactions 5905:Tert-Butyl esters 5840: 5839: 5474:Indinavir sulfate 5181:Alpha-Lipoic acid 5156:Δ-Androstenedione 5146:Δ-Androstenedione 4819: 4818: 4778: 4777: 4735:Tigilanol tiglate 4212:Enzyme inhibitors 4135: 4134: 4131: 4130: 3831:Nitrogen mustards 3801: 3800: 3561: 3560: 3263: 3262: 2424:978-0-443-07145-4 2348:10.1159/000091441 1392:body surface area 1334:This can lead to 1261:body surface area 1224:body surface area 1154:A model based on 1124:European yew tree 1090: 1089: 1071:Vaccinations for 997:Drug interactions 724: 723: 652:Interactive image 542:CompTox Dashboard 246: 231: 218: 150: 117: 16:(Redirected from 5922: 5857: 5856: 5855: 5848: 5759:Thiamylal sodium 5494:γ-linolenic acid 5490:α-Linolenic acid 5488:Linolenic acid: 5479:Lasalocid sodium 5469:(St John's wort) 5361:Docusate calcium 5291:Cyclophosphamide 5166:Allopregnanediol 5151:Δ-Androstenediol 5126: 5122: 5080:Ethinylestradiol 4930:Cyclophosphamide 4870: 4866: 4846: 4839: 4832: 4823: 4740:Tisagenlecleucel 4497:Arsenic trioxide 4208: 4141:Photosensitizers 3932:Alkyl sulfonates 3846:Cyclophosphamide 3818: 3757:Anthracenediones 3578: 3552:Hydroxycarbamide 3293: 3276: 3154: 3114: 3107: 3100: 3091: 3084: 3083: 3081: 3080: 3065: 3059: 3058: 3056: 3045: 3037: 3031: 3030: 3028: 3027: 3018:. Archived from 3008: 3002: 3001: 2999: 2998: 2983: 2977: 2976: 2948: 2942: 2941: 2939: 2938: 2929:. Archived from 2919: 2913: 2912: 2902: 2870: 2851: 2850: 2839:10.1002/rcm.2072 2814: 2805: 2804: 2794: 2779:Clin. Cancer Res 2770: 2761: 2760: 2758: 2757: 2742: 2736: 2735: 2725: 2693: 2687: 2686: 2678: 2672: 2671: 2661: 2651: 2619: 2610: 2609: 2578:Invest New Drugs 2573: 2558: 2555: 2546: 2545: 2535: 2511: 2505: 2504: 2494: 2470: 2464: 2463: 2435: 2429: 2428: 2410: 2401: 2400: 2398: 2396: 2381: 2372: 2371: 2327: 2321: 2320: 2309: 2290: 2289: 2279: 2269: 2245: 2239: 2238: 2201: 2195: 2194: 2158: 2145: 2144: 2142: 2140: 2125: 2108: 2107: 2097: 2073: 2060: 2059: 2057: 2055: 2046:. Archived from 2036: 1993: 1992: 1956: 1891: 1890: 1888: 1887: 1872: 1863: 1862: 1851: 1845: 1844: 1820: 1814: 1813: 1785: 1748: 1747: 1745: 1726: 1720: 1719: 1695: 1689: 1688: 1671: 1665: 1664: 1654: 1643:10.1002/rcr2.802 1622: 1613: 1612: 1610: 1608: 1589: 1583: 1582: 1580: 1578: 1563: 1538: 1537: 1535: 1533: 1515: 1509: 1508: 1506: 1504: 1489: 1483: 1482: 1480: 1478: 1463: 1457: 1456: 1454: 1452: 1442:nctr-crs.fda.gov 1434: 1428: 1427: 1425: 1423: 1408: 1358: 1284:Molecular target 1182:Pharmacokinetics 1119:Taxus brevifolia 1028: 948:thrombocytopenia 786:nausea, vomiting 749:. This includes 720: 719: 712: 654: 634: 619: 616: 610: 604: 587: 576: 565: 564: 550: 548: 533: 513: 493: 473: 453: 433: 413: 393: 383: 382: 368: 302: 244: 241: 236: 229: 226: 216: 213: 191: 148: 145: 127: 116: 113: 100: 86: 53: 44: 37: 35: 21: 5930: 5929: 5925: 5924: 5923: 5921: 5920: 5919: 5880:Benzoate esters 5865: 5864: 5863: 5853: 5851: 5843: 5841: 5836: 5818: 5719:Suberoylanilide 5436:Fluorometholone 5331:Dibunate sodium 5211:Aurothioglucose 5124: 5114: 5050:3,17β-Estradiol 4868: 4858: 4850: 4820: 4815: 4814: 4799:Clinical trials 4774: 4480:Other/ungrouped 4475: 4426: 4199: 4179:Porfimer sodium 4127: 4089: 4022: 3979: 3809: 3797: 3681: 3651: 3569: 3557: 3532: 3428: 3348: 3284: 3282:antimetabolites 3280: 3279:DNA precursors/ 3271: 3269:DNA replication 3259: 3199: 3169:Vinca alkaloids 3145: 3133: 3118: 3088: 3087: 3078: 3076: 3067: 3066: 3062: 3054: 3043: 3039: 3038: 3034: 3025: 3023: 3010: 3009: 3005: 2996: 2994: 2985: 2984: 2980: 2950: 2949: 2945: 2936: 2934: 2921: 2920: 2916: 2879:Mol. Biol. Cell 2872: 2871: 2854: 2825:(17): 2419–26. 2816: 2815: 2808: 2772: 2771: 2764: 2755: 2753: 2744: 2743: 2739: 2695: 2694: 2690: 2680: 2679: 2675: 2621: 2620: 2613: 2575: 2574: 2561: 2556: 2549: 2526:(12): 3016–23. 2513: 2512: 2508: 2472: 2471: 2467: 2437: 2436: 2432: 2425: 2412: 2411: 2404: 2394: 2392: 2383: 2382: 2375: 2329: 2328: 2324: 2311: 2310: 2293: 2247: 2246: 2242: 2203: 2202: 2198: 2160: 2159: 2148: 2138: 2136: 2127: 2126: 2111: 2088:(15): 1502–12. 2082:N. Engl. J. Med 2075: 2074: 2063: 2053: 2051: 2038: 2037: 1996: 1958: 1957: 1894: 1885: 1883: 1874: 1873: 1866: 1853: 1852: 1848: 1827:(4): CD005247. 1822: 1821: 1817: 1796:(17): 2513–31. 1787: 1786: 1751: 1728: 1727: 1723: 1712: 1697: 1696: 1692: 1685: 1673: 1672: 1668: 1624: 1623: 1616: 1606: 1604: 1591: 1590: 1586: 1576: 1574: 1565: 1564: 1541: 1531: 1529: 1519:"Taxotere EPAR" 1517: 1516: 1512: 1502: 1500: 1491: 1490: 1486: 1476: 1474: 1465: 1464: 1460: 1450: 1448: 1436: 1435: 1431: 1421: 1419: 1410: 1409: 1405: 1400: 1388: 1356: 1349: 1344: 1331: 1303: 1301:Modes of action 1286: 1281: 1257: 1241:cytochrome P450 1237: 1189: 1184: 1152: 1136: 1106: 999: 990: 970: 902: 889: 880: 859: 830: 763:prostate cancer 715: 713: 710:(what is this?) 707: 702: 699: 694: 689: 688: 677: 674: 669: 668: 657: 632: 622: 613: 607: 568: 544: 536: 516: 496: 476: 456: 436: 416: 396: 379: 371: 351: 348: 335: 334: 300: 277:Protein binding 267:Bioavailability 259:Pharmacokinetic 253: 234: 195: 163: 156: 137: 130: 28: 23: 22: 15: 12: 11: 5: 5928: 5926: 5918: 5917: 5912: 5907: 5902: 5897: 5892: 5887: 5882: 5877: 5875:Acetate esters 5867: 5866: 5862: 5861: 5838: 5837: 5835: 5834: 5827: 5823: 5820: 5819: 5817: 5816: 5811: 5802: 5801: 5796: 5791: 5786: 5784:Troleandomycin 5781: 5776: 5771: 5766: 5761: 5756: 5751: 5746: 5741: 5736: 5731: 5726: 5721: 5716: 5711: 5706: 5704:Spironolactone 5701: 5696: 5691: 5686: 5681: 5676: 5671: 5666: 5661: 5656: 5651: 5646: 5641: 5636: 5631: 5626: 5621: 5616: 5611: 5606: 5601: 5596: 5591: 5586: 5581: 5576: 5574:Norelgestromin 5571: 5566: 5561: 5556: 5551: 5546: 5541: 5536: 5531: 5526: 5521: 5516: 5511: 5506: 5501: 5496: 5486: 5481: 5476: 5471: 5463: 5458: 5453: 5448: 5443: 5438: 5433: 5431:Flucloxacillin 5428: 5423: 5418: 5413: 5408: 5403: 5398: 5393: 5388: 5383: 5378: 5373: 5368: 5363: 5358: 5353: 5348: 5343: 5338: 5333: 5328: 5318: 5308: 5303: 5298: 5293: 5288: 5286:Corticosterone 5283: 5278: 5273: 5268: 5263: 5258: 5253: 5251:Chlorpromazine 5248: 5243: 5238: 5233: 5228: 5223: 5218: 5213: 5208: 5203: 5198: 5193: 5188: 5183: 5178: 5173: 5168: 5163: 5158: 5153: 5148: 5143: 5138: 5129: 5127: 5116: 5115: 5113: 5112: 5107: 5102: 5097: 5092: 5087: 5082: 5077: 5072: 5070:17-Androstanol 5067: 5065:3β-Androstanol 5062: 5060:3α-Androstenol 5057: 5055:3α-Androstanol 5052: 5043: 5042: 5037: 5032: 5027: 5022: 5017: 5012: 5007: 5002: 4997: 4992: 4987: 4982: 4977: 4972: 4967: 4962: 4957: 4952: 4947: 4937: 4932: 4927: 4922: 4917: 4912: 4910:Chlorpromazine 4907: 4902: 4897: 4892: 4887: 4882: 4873: 4871: 4860: 4859: 4851: 4849: 4848: 4841: 4834: 4826: 4817: 4816: 4813: 4812: 4811: 4810: 4807: 4796: 4790: 4784: 4783: 4780: 4779: 4776: 4775: 4773: 4772: 4767: 4762: 4757: 4752: 4747: 4742: 4737: 4732: 4727: 4722: 4717: 4712: 4707: 4702: 4697: 4692: 4686: 4675: 4670: 4665: 4660: 4655: 4650: 4645: 4640: 4635: 4630: 4625: 4620: 4615: 4610: 4605: 4600: 4595: 4590: 4585: 4580: 4575: 4570: 4565: 4560: 4555: 4550: 4545: 4540: 4535: 4530: 4525: 4520: 4515: 4499: 4494: 4489: 4483: 4481: 4477: 4476: 4474: 4473: 4461: 4449: 4436: 4434: 4428: 4427: 4425: 4424: 4418: 4413: 4408: 4403: 4391: 4385: 4380: 4375: 4370: 4359: 4353: 4348: 4340: 4333:PARP inhibitor 4329: 4317: 4305: 4293: 4292: 4291: 4286: 4281: 4276: 4264: 4258: 4253: 4248: 4243: 4229: 4216: 4214: 4205: 4201: 4200: 4198: 4197: 4191: 4186: 4181: 4170: 4165: 4160: 4155: 4149: 4147: 4137: 4136: 4133: 4132: 4129: 4128: 4126: 4125: 4119: 4114: 4109: 4099: 4097: 4091: 4090: 4088: 4087: 4081: 4076: 4065: 4060: 4055: 4050: 4038: 4032: 4030: 4024: 4023: 4021: 4020: 4015: 4010: 4005: 4000: 3995: 3989: 3987: 3985:Platinum-based 3981: 3980: 3978: 3977: 3972: 3967: 3962: 3950: 3949: 3943: 3927: 3926: 3921: 3916: 3911: 3901: 3896: 3884: 3883: 3878: 3873: 3863: 3858: 3852: 3843: 3838: 3826: 3824: 3815: 3803: 3802: 3799: 3798: 3796: 3795: 3790: 3785: 3780: 3775: 3769: 3764: 3753: 3747: 3742: 3737: 3732: 3727: 3722: 3712: 3707: 3700:Anthracyclines 3695: 3693: 3683: 3682: 3680: 3679: 3673: 3661: 3659: 3653: 3652: 3650: 3649: 3643: 3638: 3633: 3628: 3623: 3618: 3613: 3608: 3603: 3598: 3586: 3584: 3575: 3563: 3562: 3559: 3558: 3556: 3555: 3542: 3540: 3534: 3533: 3531: 3530: 3524: 3512: 3511: 3498: 3497: 3481: 3480: 3470: 3465: 3460: 3455: 3450: 3438: 3436: 3430: 3429: 3427: 3426: 3420: 3418:Mercaptopurine 3409: 3404: 3399: 3393: 3388: 3372: 3371: 3358: 3356: 3350: 3349: 3347: 3346: 3340: 3329: 3323: 3318: 3313: 3301: 3299: 3290: 3273: 3265: 3264: 3261: 3260: 3258: 3257: 3245: 3239: 3234: 3229: 3224: 3219: 3207: 3205: 3201: 3200: 3198: 3197: 3191: 3186: 3181: 3176: 3164: 3162: 3151: 3135: 3134: 3120:Intracellular 3119: 3117: 3116: 3109: 3102: 3094: 3086: 3085: 3060: 3032: 3003: 2978: 2943: 2914: 2852: 2806: 2785:(6): 1976–83. 2762: 2737: 2708:(6): 754–767. 2688: 2673: 2611: 2559: 2547: 2506: 2465: 2446:(5): 994–995. 2430: 2423: 2402: 2373: 2322: 2291: 2240: 2196: 2146: 2109: 2061: 1994: 1892: 1864: 1861:on 2014-04-28. 1846: 1815: 1749: 1721: 1710: 1690: 1683: 1666: 1614: 1599:. 2006-10-05. 1584: 1539: 1510: 1484: 1473:. 21 June 2022 1458: 1429: 1402: 1401: 1399: 1396: 1387: 1384: 1372:Gif-sur-Yvette 1353:Sanofi-Aventis 1348: 1345: 1343: 1340: 1330: 1327: 1302: 1299: 1285: 1282: 1280: 1277: 1253: 1236: 1233: 1188: 1185: 1183: 1180: 1151: 1150:Active regions 1148: 1140:polysorbate 80 1135: 1132: 1105: 1102: 1088: 1087: 1084: 1080: 1079: 1076: 1068: 1067: 1064: 1060: 1059: 1056: 1052: 1051: 1048: 1044: 1043: 1040: 1036: 1035: 1032: 998: 995: 989: 986: 978:Kidney failure 969: 966: 901: 898: 888: 885: 879: 876: 858: 855: 829: 826: 795:liver problems 759:stomach cancer 722: 721: 704: 703: 701: 700: 697: 695: 692: 684: 683: 682: 679: 678: 676: 675: 672: 664: 663: 662: 659: 658: 656: 655: 647: 645: 637: 636: 630: 624: 623: 620: 611: 605: 600: 594: 593: 589: 588: 578: 570: 569: 567: 566: 553: 551: 538: 537: 535: 534: 526: 524: 518: 517: 515: 514: 506: 504: 498: 497: 495: 494: 486: 484: 478: 477: 475: 474: 466: 464: 458: 457: 455: 454: 446: 444: 438: 437: 435: 434: 426: 424: 418: 417: 415: 414: 406: 404: 398: 397: 395: 394: 386: 384: 373: 372: 370: 369: 361: 359: 353: 352: 350: 349: 338: 330: 329: 328: 325: 324: 320: 319: 314: 308: 307: 304: 295: 294: 289: 283: 282: 279: 273: 272: 269: 263: 262: 255: 254: 252: 251: 248: 239: 224: 210: 208: 202: 201: 197: 196: 194: 193: 180: 178: 172: 171: 166: 164:administration 158: 157: 155: 154: 152: 142: 140: 132: 131: 129: 128: 110: 108: 102: 101: 94: 88: 87: 80: 70: 69: 66: 60: 59: 55: 54: 46: 45: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 5927: 5916: 5913: 5911: 5908: 5906: 5903: 5901: 5898: 5896: 5893: 5891: 5888: 5886: 5883: 5881: 5878: 5876: 5873: 5872: 5870: 5860: 5850: 5846: 5833: 5832: 5828: 5825: 5824: 5821: 5815: 5812: 5810: 5807: 5804: 5803: 5800: 5797: 5795: 5792: 5790: 5787: 5785: 5782: 5780: 5777: 5775: 5772: 5770: 5767: 5765: 5762: 5760: 5757: 5755: 5752: 5750: 5747: 5745: 5742: 5740: 5737: 5735: 5732: 5730: 5727: 5725: 5724:Sulfisoxazole 5722: 5720: 5717: 5715: 5712: 5710: 5707: 5705: 5702: 5700: 5697: 5695: 5692: 5690: 5687: 5685: 5682: 5680: 5677: 5675: 5672: 5670: 5667: 5665: 5662: 5660: 5657: 5655: 5652: 5650: 5647: 5645: 5642: 5640: 5637: 5635: 5632: 5630: 5627: 5625: 5622: 5620: 5617: 5615: 5612: 5610: 5607: 5605: 5602: 5600: 5599:Phenobarbital 5597: 5595: 5592: 5590: 5587: 5585: 5582: 5580: 5577: 5575: 5572: 5570: 5567: 5565: 5562: 5560: 5557: 5555: 5552: 5550: 5547: 5545: 5542: 5540: 5537: 5535: 5532: 5530: 5527: 5525: 5522: 5520: 5517: 5515: 5512: 5510: 5507: 5505: 5502: 5500: 5497: 5495: 5491: 5487: 5485: 5484:Levothyroxine 5482: 5480: 5477: 5475: 5472: 5470: 5468: 5464: 5462: 5459: 5457: 5454: 5452: 5449: 5447: 5446:Guggulsterone 5444: 5442: 5439: 5437: 5434: 5432: 5429: 5427: 5424: 5422: 5419: 5417: 5414: 5412: 5409: 5407: 5404: 5402: 5399: 5397: 5394: 5392: 5389: 5387: 5384: 5382: 5379: 5377: 5374: 5372: 5369: 5367: 5364: 5362: 5359: 5357: 5354: 5352: 5349: 5347: 5344: 5342: 5341:Dicloxacillin 5339: 5337: 5334: 5332: 5329: 5326: 5322: 5319: 5316: 5312: 5309: 5307: 5306:Dexamethasone 5304: 5302: 5299: 5297: 5294: 5292: 5289: 5287: 5284: 5282: 5279: 5277: 5274: 5272: 5269: 5267: 5264: 5262: 5259: 5257: 5254: 5252: 5249: 5247: 5244: 5242: 5241:Cephaloridine 5239: 5237: 5234: 5232: 5229: 5227: 5224: 5222: 5219: 5217: 5214: 5212: 5209: 5207: 5204: 5202: 5199: 5197: 5194: 5192: 5189: 5187: 5184: 5182: 5179: 5177: 5174: 5172: 5169: 5167: 5164: 5162: 5159: 5157: 5154: 5152: 5149: 5147: 5144: 5142: 5139: 5137: 5134: 5131: 5130: 5128: 5123: 5117: 5111: 5108: 5106: 5103: 5101: 5098: 5096: 5093: 5091: 5088: 5086: 5083: 5081: 5078: 5076: 5073: 5071: 5068: 5066: 5063: 5061: 5058: 5056: 5053: 5051: 5048: 5045: 5044: 5041: 5040:Valproic acid 5038: 5036: 5033: 5031: 5028: 5026: 5023: 5021: 5018: 5016: 5013: 5011: 5008: 5006: 5003: 5001: 5000:Phenobarbital 4998: 4996: 4993: 4991: 4988: 4986: 4983: 4981: 4978: 4976: 4973: 4971: 4968: 4966: 4963: 4961: 4958: 4956: 4953: 4951: 4948: 4945: 4941: 4938: 4936: 4933: 4931: 4928: 4926: 4923: 4921: 4918: 4916: 4913: 4911: 4908: 4906: 4903: 4901: 4900:Carbamazepine 4898: 4896: 4893: 4891: 4888: 4886: 4883: 4881: 4878: 4875: 4874: 4872: 4867: 4861: 4857: 4854: 4847: 4842: 4840: 4835: 4833: 4828: 4827: 4824: 4808: 4806: 4803: 4802: 4800: 4797: 4794: 4791: 4789: 4786: 4785: 4781: 4771: 4768: 4766: 4763: 4761: 4758: 4756: 4753: 4751: 4748: 4746: 4743: 4741: 4738: 4736: 4733: 4731: 4728: 4726: 4723: 4721: 4718: 4716: 4713: 4711: 4708: 4706: 4703: 4701: 4698: 4696: 4693: 4690: 4687: 4685: 4681: 4680: 4676: 4674: 4673:Tabelecleucel 4671: 4669: 4666: 4664: 4661: 4659: 4656: 4654: 4651: 4649: 4646: 4644: 4641: 4639: 4636: 4634: 4633:Lurbinectedin 4631: 4629: 4626: 4624: 4621: 4619: 4616: 4614: 4611: 4609: 4606: 4604: 4601: 4599: 4596: 4594: 4591: 4589: 4586: 4584: 4581: 4579: 4576: 4574: 4571: 4569: 4566: 4564: 4561: 4559: 4556: 4554: 4551: 4549: 4546: 4544: 4541: 4539: 4536: 4534: 4531: 4529: 4526: 4524: 4521: 4519: 4516: 4513: 4509: 4505: 4504: 4500: 4498: 4495: 4493: 4490: 4488: 4485: 4484: 4482: 4478: 4471: 4467: 4466: 4462: 4459: 4455: 4454: 4450: 4447: 4443: 4442: 4438: 4437: 4435: 4433: 4429: 4422: 4419: 4417: 4414: 4412: 4409: 4407: 4404: 4402: 4398: 4396: 4392: 4389: 4386: 4384: 4381: 4379: 4376: 4374: 4371: 4369: 4365: 4364: 4360: 4357: 4354: 4352: 4349: 4347: 4344: 4341: 4339: 4335: 4334: 4330: 4327: 4323: 4322: 4318: 4315: 4311: 4310: 4306: 4303: 4299: 4298: 4294: 4290: 4287: 4285: 4282: 4280: 4277: 4275: 4272: 4271: 4270: 4269: 4265: 4262: 4259: 4257: 4254: 4252: 4249: 4247: 4244: 4242: 4238: 4237: 4234: 4230: 4227: 4223: 4222: 4218: 4217: 4215: 4213: 4209: 4206: 4202: 4195: 4192: 4190: 4187: 4185: 4182: 4180: 4176: 4175: 4171: 4169: 4166: 4164: 4161: 4159: 4156: 4154: 4151: 4150: 4148: 4146: 4142: 4138: 4123: 4120: 4118: 4115: 4113: 4110: 4108: 4104: 4101: 4100: 4098: 4096: 4095:Intercalation 4092: 4085: 4082: 4080: 4077: 4075: 4071: 4070: 4066: 4064: 4061: 4059: 4056: 4054: 4051: 4048: 4044: 4043: 4039: 4037: 4034: 4033: 4031: 4029: 4025: 4019: 4016: 4014: 4011: 4009: 4006: 4004: 4003:Dicycloplatin 4001: 3999: 3996: 3994: 3991: 3990: 3988: 3986: 3982: 3976: 3973: 3971: 3968: 3966: 3963: 3961: 3958: 3956: 3952: 3951: 3947: 3944: 3942: 3938: 3935: 3933: 3929: 3928: 3925: 3922: 3920: 3917: 3915: 3912: 3909: 3905: 3902: 3900: 3897: 3895: 3892: 3890: 3886: 3885: 3882: 3879: 3877: 3876:Prednimustine 3874: 3871: 3867: 3864: 3862: 3859: 3856: 3853: 3851: 3847: 3844: 3842: 3839: 3837: 3834: 3832: 3828: 3827: 3825: 3823: 3819: 3816: 3813: 3808: 3804: 3794: 3791: 3789: 3786: 3784: 3781: 3779: 3776: 3773: 3770: 3768: 3765: 3763: 3759: 3758: 3754: 3751: 3748: 3746: 3743: 3741: 3738: 3736: 3733: 3731: 3728: 3726: 3723: 3720: 3716: 3713: 3711: 3708: 3706: 3702: 3701: 3697: 3696: 3694: 3692: 3691:Intercalation 3688: 3684: 3677: 3674: 3672: 3668: 3667: 3663: 3662: 3660: 3658: 3654: 3647: 3644: 3642: 3639: 3637: 3634: 3632: 3629: 3627: 3624: 3622: 3619: 3617: 3614: 3612: 3609: 3607: 3604: 3602: 3599: 3597: 3593: 3592: 3588: 3587: 3585: 3583: 3579: 3576: 3573: 3568: 3564: 3553: 3549: 3548: 3544: 3543: 3541: 3539: 3535: 3528: 3525: 3523: 3519: 3518: 3514: 3513: 3509: 3505: 3504: 3500: 3499: 3495: 3494:+daunorubicin 3492: 3488: 3487: 3483: 3482: 3478: 3474: 3471: 3469: 3466: 3464: 3461: 3459: 3458:Doxifluridine 3456: 3454: 3451: 3449: 3445: 3444: 3440: 3439: 3437: 3435: 3431: 3424: 3421: 3419: 3415: 3414: 3410: 3408: 3407:Rabacfosadine 3405: 3403: 3400: 3397: 3394: 3392: 3389: 3387: 3383: 3382: 3378: 3374: 3373: 3369: 3365: 3364: 3360: 3359: 3357: 3355: 3351: 3344: 3341: 3339: 3335: 3334: 3330: 3327: 3324: 3322: 3319: 3317: 3314: 3312: 3308: 3307: 3303: 3302: 3300: 3298: 3294: 3291: 3288: 3283: 3277: 3274: 3270: 3266: 3255: 3251: 3250: 3246: 3243: 3240: 3238: 3235: 3233: 3230: 3228: 3225: 3223: 3220: 3218: 3214: 3213: 3209: 3208: 3206: 3202: 3195: 3192: 3190: 3187: 3185: 3182: 3180: 3177: 3175: 3171: 3170: 3166: 3165: 3163: 3160: 3155: 3152: 3149: 3144: 3140: 3136: 3131: 3127: 3123: 3115: 3110: 3108: 3103: 3101: 3096: 3095: 3092: 3074: 3070: 3064: 3061: 3053: 3049: 3042: 3036: 3033: 3022:on 2007-06-23 3021: 3017: 3013: 3007: 3004: 2992: 2988: 2982: 2979: 2974: 2970: 2966: 2962: 2958: 2954: 2947: 2944: 2933:on 2006-10-22 2932: 2928: 2924: 2918: 2915: 2910: 2906: 2901: 2896: 2892: 2888: 2885:(4): 947–59. 2884: 2880: 2876: 2869: 2867: 2865: 2863: 2861: 2859: 2857: 2853: 2848: 2844: 2840: 2836: 2832: 2828: 2824: 2820: 2813: 2811: 2807: 2802: 2798: 2793: 2788: 2784: 2780: 2776: 2769: 2767: 2763: 2751: 2747: 2741: 2738: 2733: 2729: 2724: 2719: 2715: 2711: 2707: 2703: 2699: 2692: 2689: 2684: 2677: 2674: 2669: 2665: 2660: 2655: 2650: 2645: 2641: 2637: 2634:(9): 5312–6. 2633: 2629: 2625: 2618: 2616: 2612: 2607: 2603: 2599: 2595: 2591: 2587: 2584:(2): 147–51. 2583: 2579: 2572: 2570: 2568: 2566: 2564: 2560: 2554: 2552: 2548: 2543: 2539: 2534: 2529: 2525: 2521: 2517: 2510: 2507: 2502: 2498: 2493: 2488: 2485:(3): 263–80. 2484: 2480: 2476: 2469: 2466: 2461: 2457: 2453: 2449: 2445: 2441: 2440:Ophthalmology 2434: 2431: 2426: 2420: 2416: 2409: 2407: 2403: 2390: 2386: 2380: 2378: 2374: 2369: 2365: 2361: 2357: 2353: 2349: 2345: 2342:(6): 401–14. 2341: 2337: 2333: 2326: 2323: 2318: 2314: 2308: 2306: 2304: 2302: 2300: 2298: 2296: 2292: 2287: 2283: 2278: 2273: 2268: 2263: 2259: 2255: 2251: 2244: 2241: 2236: 2232: 2228: 2224: 2220: 2216: 2213:(2): 117–25. 2212: 2208: 2200: 2197: 2192: 2188: 2184: 2180: 2176: 2172: 2168: 2164: 2157: 2155: 2153: 2151: 2147: 2134: 2130: 2124: 2122: 2120: 2118: 2116: 2114: 2110: 2105: 2101: 2096: 2091: 2087: 2083: 2079: 2072: 2070: 2068: 2066: 2062: 2050:on 2010-06-03 2049: 2045: 2041: 2035: 2033: 2031: 2029: 2027: 2025: 2023: 2021: 2019: 2017: 2015: 2013: 2011: 2009: 2007: 2005: 2003: 2001: 1999: 1995: 1990: 1986: 1982: 1978: 1974: 1970: 1967:(2): 99–114. 1966: 1962: 1955: 1953: 1951: 1949: 1947: 1945: 1943: 1941: 1939: 1937: 1935: 1933: 1931: 1929: 1927: 1925: 1923: 1921: 1919: 1917: 1915: 1913: 1911: 1909: 1907: 1905: 1903: 1901: 1899: 1897: 1893: 1881: 1877: 1871: 1869: 1865: 1860: 1856: 1850: 1847: 1842: 1838: 1834: 1830: 1826: 1819: 1816: 1811: 1807: 1803: 1799: 1795: 1791: 1784: 1782: 1780: 1778: 1776: 1774: 1772: 1770: 1768: 1766: 1764: 1762: 1760: 1758: 1756: 1754: 1750: 1744: 1739: 1735: 1731: 1725: 1722: 1717: 1713: 1711:9783527607495 1707: 1703: 1702: 1694: 1691: 1686: 1684:9780857111562 1680: 1676: 1670: 1667: 1662: 1658: 1653: 1648: 1644: 1640: 1637:(7): e00802. 1636: 1632: 1628: 1621: 1619: 1615: 1602: 1598: 1594: 1588: 1585: 1572: 1568: 1562: 1560: 1558: 1556: 1554: 1552: 1550: 1548: 1546: 1544: 1540: 1527: 1525: 1520: 1514: 1511: 1498: 1494: 1488: 1485: 1472: 1468: 1462: 1459: 1447: 1443: 1439: 1433: 1430: 1418:. 4 June 2020 1417: 1413: 1407: 1404: 1397: 1395: 1393: 1385: 1383: 1381: 1377: 1373: 1369: 1365: 1364:Pierre Potier 1360: 1354: 1346: 1341: 1339: 1337: 1328: 1326: 1323: 1320: 1316: 1310: 1308: 1300: 1298: 1296: 1291: 1283: 1278: 1276: 1272: 1268: 1264: 1262: 1256: 1252: 1249: 1245: 1242: 1234: 1232: 1229: 1226:) of 1.68 m. 1225: 1221: 1216: 1213: 1208: 1206: 1201: 1196: 1194: 1186: 1181: 1179: 1177: 1173: 1169: 1165: 1161: 1157: 1149: 1147: 1143: 1141: 1133: 1131: 1127: 1125: 1121: 1120: 1115: 1111: 1103: 1101: 1098: 1094: 1085: 1082: 1081: 1077: 1074: 1070: 1069: 1065: 1062: 1061: 1057: 1054: 1053: 1049: 1046: 1045: 1041: 1038: 1037: 1033: 1030: 1029: 1023: 1020: 1016: 1012: 1008: 1007:dexamethasone 1004: 996: 994: 987: 985: 982: 979: 974: 967: 965: 962: 959: 955: 951: 949: 945: 942: 938: 934: 929: 926: 915: 906: 899: 897: 893: 886: 884: 878:Breast cancer 877: 875: 871: 869: 865: 856: 854: 850: 843: 839: 838:breast cancer 834: 827: 825: 823: 819: 814: 812: 811:cell division 808: 804: 800: 797:. Use during 796: 791: 787: 783: 779: 774: 772: 768: 764: 760: 756: 752: 751:breast cancer 748: 744: 740: 736: 732: 728: 718: 711: 705: 696: 691: 687: 680: 671: 667: 660: 653: 649: 648: 646: 643: 638: 631: 629: 625: 601: 599: 595: 590: 586: 582: 579: 577: 575:ECHA InfoCard 571: 563: 559: 558:DTXSID0040464 555: 554: 552: 543: 539: 532: 528: 527: 525: 523: 519: 512: 508: 507: 505: 503: 499: 492: 488: 487: 485: 483: 479: 472: 468: 467: 465: 463: 459: 452: 448: 447: 445: 443: 439: 432: 428: 427: 425: 423: 419: 412: 408: 407: 405: 403: 399: 392: 388: 387: 385: 378: 374: 367: 363: 362: 360: 358: 354: 346: 342: 337: 333: 326: 321: 318: 315: 313: 309: 305: 303: 296: 293: 290: 288: 284: 280: 278: 274: 270: 268: 264: 260: 256: 249: 247: Rx-only 240: 237: 225: 222: 212: 211: 209: 207: 203: 198: 190: 185: 182: 181: 179: 177: 173: 170: 167: 165: 159: 153: 144: 143: 141: 139: 133: 126: 121: 112: 111: 109: 107: 103: 99: 95: 93: 89: 85: 81: 79: 75: 71: 67: 65: 61: 58:Clinical data 56: 52: 47: 43: 38: 30: 19: 5829: 5809:Ketoconazole 5806:Antagonists: 5805: 5779:Troglitazone 5754:Tetracycline 5709:Spiroxatrine 5654:Quingestrone 5649:Progesterone 5634:Pregnenolone 5629:Pregnanolone 5619:Pregnanediol 5614:Prednisolone 5539:Mifepristone 5466: 5441:Griseofulvin 5421:Fenbendazole 5406:Famprofazone 5401:Erythromycin 5396:Epothilone B 5381:Eburnamonine 5355: 5276:Clotrimazole 5266:Clofenvinfos 5201:Antimycotics 5132: 5095:Okadaic acid 5047:Antagonists: 5046: 5035:Troglitazone 4970:Mifepristone 4965:Methoxychlor 4960:Griseofulvin 4955:Ellagic acid 4935:Cypermethrin 4925:Clotrimazole 4876: 4720:Tazemetostat 4684:Alitretinoin 4677: 4588:Estramustine 4568:Elsamitrucin 4558:Eflornithine 4512:Pegaspargase 4508:Asparaginase 4501: 4470:Testolactone 4463: 4451: 4439: 4393: 4378:Panobinostat 4361: 4331: 4319: 4307: 4295: 4266: 4231: 4219: 4172: 4168:Padeliporfin 4107:Dactinomycin 4103:Streptomyces 4084:Temozolomide 4079:Mitozolomide 4067: 4058:Mitobronitol 4047:Procarbazine 4040: 4028:Nonclassical 3953: 3930: 3924:Streptozocin 3889:Nitrosoureas 3887: 3861:Chlorambucil 3855:Trofosfamide 3841:Chlormethine 3836:Bendamustine 3829: 3767:Mitoxantrone 3762:Losoxantrone 3755: 3715:Daunorubicin 3698: 3664: 3601:Camptothecin 3589: 3545: 3515: 3501: 3484: 3468:Fluorouracil 3448:Capecitabine 3441: 3411: 3375: 3361: 3331: 3326:Pralatrexate 3316:Methotrexate 3304: 3247: 3221: 3210: 3167: 3077:. Retrieved 3063: 3052:the original 3047: 3035: 3024:. Retrieved 3020:the original 3015: 3006: 2995:. Retrieved 2981: 2956: 2952: 2946: 2935:. Retrieved 2931:the original 2926: 2917: 2882: 2878: 2822: 2818: 2782: 2778: 2754:. Retrieved 2740: 2705: 2701: 2691: 2682: 2676: 2631: 2627: 2581: 2577: 2523: 2519: 2509: 2482: 2478: 2468: 2443: 2439: 2433: 2415:Pharmacology 2414: 2393:. Retrieved 2339: 2335: 2325: 2316: 2257: 2253: 2243: 2210: 2206: 2199: 2166: 2162: 2137:. Retrieved 2085: 2081: 2052:. Retrieved 2048:the original 2043: 1964: 1960: 1884:. Retrieved 1859:the original 1849: 1824: 1818: 1793: 1789: 1743:10665/325771 1733: 1724: 1700: 1693: 1674: 1669: 1634: 1630: 1605:. Retrieved 1596: 1587: 1575:. Retrieved 1530:. Retrieved 1522: 1513: 1501:. Retrieved 1496: 1487: 1475:. Retrieved 1470: 1461: 1449:. Retrieved 1441: 1432: 1420:. Retrieved 1415: 1406: 1389: 1380:European yew 1361: 1350: 1332: 1324: 1318: 1314: 1311: 1304: 1290:microtubules 1287: 1273: 1269: 1265: 1258: 1254: 1238: 1217: 1209: 1205:erythrocytes 1197: 1193:cyclosporine 1190: 1158:density and 1153: 1144: 1137: 1128: 1117: 1107: 1099: 1095: 1091: 1083:Thalidomide 1072: 1000: 991: 983: 975: 971: 963: 960: 956: 952: 946:(11.0%) and 930: 921: 900:Side effects 894: 890: 881: 872: 868:mitoxantrone 860: 851: 847: 842:wine coolers 828:Medical uses 815: 807:microtubules 775: 738: 734: 730: 726: 725: 714: 708: 344: 340: 299:Elimination 206:Legal status 200:Legal status 106:License data 29: 5794:Zafirlukast 5764:Thiothixene 5744:Terconazole 5694:Simvastatin 5569:Nisoldipine 5564:Nilvadipine 5549:Nicardipine 5519:Metacycline 5346:Dimercaprol 5301:Demecolcine 5261:Clindamycin 5256:Ciglitazone 5206:Artemisinin 5186:Ambrisentan 5090:Nigramide J 5025:Telmisartan 4985:Nicardipine 4895:Benfuracarb 4890:Artemisinin 4795:from market 4765:Vorasidenib 4745:Trabectedin 4730:Tiazofurine 4725:Tebentafusp 4710:Tagraxofusp 4668:Plitidepsin 4638:Mitoguazone 4578:Epacadostat 4548:Demecolcine 4492:Aflibercept 4465:Sex steroid 4338:Fuzuloparib 4279:Carfilzomib 4251:Palbociclib 4241:Abemaciclib 4194:Verteporfin 4158:Efaproxiral 4074:Dacarbazine 4036:Altretamine 4018:Satraplatin 4013:Oxaliplatin 3993:Carboplatin 3970:Triaziquone 3941:Mannosulfan 3919:Ranimustine 3899:Fotemustine 3740:Pirarubicin 3725:Doxorubicin 3719:+cytarabine 3705:Aclarubicin 3666:Podophyllum 3591:Camptotheca 3522:Azacitidine 3508:Gemcitabine 3463:Floxuridine 3396:Fludarabine 3391:Clofarabine 3377:Halogenated 3368:Pentostatin 3343:Raltitrexed 3311:Aminopterin 3254:Ixabepilone 3249:Epothilones 3217:Cabazitaxel 3194:Vinorelbine 3179:Vincristine 3174:Vinblastine 3159:microtubule 2169:(1): 5–30. 1607:21 December 1567:"Docetaxel" 1019:vinblastine 1011:doxorubicin 944:neutropenia 933:neutropenia 635: g·mol 581:100.129.246 366:114977-28-5 323:Identifiers 169:Intravenous 92:MedlinePlus 64:Trade names 5885:Carbamates 5869:Categories 5774:Tianeptine 5739:Tenylidone 5734:Tacrolimus 5679:Rimexolone 5669:Rifampicin 5609:Plicamycin 5594:Paclitaxel 5579:Omeprazole 5559:Nifedipine 5534:Mevastatin 5529:Metyrapone 5509:Lovastatin 5504:Loratadine 5461:Hyperforin 5451:Haloprogin 5416:Felodipine 5391:Enzacamene 5371:Dronabinol 5336:Diclazuril 5315:prasterone 5271:Chloroxine 5246:Cephradine 5216:Bile acids 5030:Tolnaftate 4995:Permethrin 4980:Nevirapine 4975:Nefazodone 4944:prasterone 4905:Carvedilol 4885:Amiodarone 4856:modulators 4760:Verdinexor 4755:Venetoclax 4658:Oblimersen 4653:Navitoclax 4628:Lucanthone 4623:Lonidamine 4613:Lifileucel 4608:Ivosidenib 4603:Imetelstat 4573:Enasidenib 4563:Elesclomol 4528:Bexarotene 4523:Belzutifan 4458:Bexarotene 4446:Atrasentan 4421:Umbralisib 4416:Idelalisib 4406:Copanlisib 4388:Vorinostat 4383:Romidepsin 4373:Entinostat 4368:Belinostat 4326:Masoprocol 4314:Tiazofurin 4302:Anagrelide 4274:Bortezomib 4261:Seliciclib 4256:Ribociclib 4236:inhibitors 4226:Tipifarnib 4189:Temoporfin 4184:Talaporfin 4122:Plicamycin 4117:Mitomycins 4063:Pipobroman 4042:Hydrazines 4008:Nedaplatin 3960:Carboquone 3955:Aziridines 3946:Treosulfan 3894:Carmustine 3881:Uramustine 3850:Ifosfamide 3822:Alkylating 3783:Bisantrene 3772:Pixantrone 3745:Valrubicin 3735:Idarubicin 3730:Epirubicin 3676:Teniposide 3631:Lurtotecan 3626:Irinotecan 3527:Decitabine 3491:Cytarabine 3434:Pyrimidine 3423:Tioguanine 3413:Thiopurine 3402:Nelarabine 3386:Cladribine 3338:Pemetrexed 3321:Pemetrexed 3297:Folic acid 3237:Paclitaxel 3189:Vinflunine 3079:2010-06-10 3026:2007-07-12 2997:2014-04-20 2937:2006-10-02 2756:2012-05-09 2520:Ann. Oncol 2260:: 357–65. 1886:2006-10-02 1577:8 December 1532:28 October 1503:28 October 1422:29 October 1398:References 1376:paclitaxel 1114:paclitaxel 1039:Cisplatin 864:prednisone 640:3D model ( 628:Molar mass 511:CHEBI:4672 471:699121PHCA 442:ChemSpider 402:IUPHAR/BPS 357:CAS Number 332:IUPAC name 287:Metabolism 5699:Sirolimus 5689:Ritonavir 5684:Riodipine 5674:Rifaximin 5659:Reserpine 5644:Proadifen 5589:Oxatomide 5544:Nafcillin 5514:Meclizine 5376:Droxidopa 5356:Docetaxel 5281:Colforsin 5231:Bumecaine 5221:Bithionol 5133:Agonists: 5110:T-0901317 5085:Meclizine 5015:Reserpine 5005:Phenytoin 4990:Octicizer 4950:Efavirenz 4877:Agonists: 4805:Phase III 4793:Withdrawn 4770:Vosaroxin 4750:Veliparib 4705:Sotorasib 4695:Selinexor 4689:Tretinoin 4679:Retinoids 4593:Glasdegib 4538:Celecoxib 4487:Adagrasib 4411:Duvelisib 4401:Alpelisib 4356:Rucaparib 4343:Niraparib 4284:Oprozomib 4246:Alvocidib 4112:Bleomycin 4069:Triazenes 4053:Etoglucid 3998:Cisplatin 3914:Nimustine 3908:Semustine 3904:Lomustine 3866:Melphalan 3793:Menogaril 3788:Crisnatol 3778:Amsacrine 3750:Zorubicin 3710:Amrubicin 3671:Etoposide 3646:Topotecan 3641:Silatecan 3636:Rubitecan 3621:Gimatecan 3606:Cositecan 3596:Belotecan 3272:inhibitor 3242:Tesetaxel 3232:Ortataxel 3227:Larotaxel 3222:Docetaxel 3184:Vindesine 2395:2 October 2139:2 October 1416:Drugs.com 1394:1.75 m). 1212:half-life 1164:β-tubulin 1104:Chemistry 1015:etoposide 1003:Cisplatin 988:Pregnancy 939:(90.4%), 935:(95.5%), 925:hair loss 799:pregnancy 782:cytopenia 778:hair loss 727:Docetaxel 317:Bile duct 312:Excretion 301:half-life 162:Routes of 136:Pregnancy 125:Docetaxel 84:Monograph 78:Drugs.com 34:Docetaxel 5859:Medicine 5826:See also 5714:SR-12813 5604:Piperine 5584:Orlistat 5554:Nicotine 5426:Fentanyl 5411:Febantel 5386:Ecopipam 5351:Dinaline 5236:Cafestol 5226:Bosentan 5100:PK-11195 4643:Mitotane 4583:Eribulin 4351:Olaparib 4289:Ixazomib 3965:Thiotepa 3937:Busulfan 3616:Exatecan 3453:Carmofur 3161:assembly 3124: / 3073:Archived 2991:Archived 2973:26830311 2959:: 1–12. 2909:10198049 2847:16059877 2801:15041715 2750:Archived 2732:29796927 2668:11309480 2606:24497910 2542:22875836 2501:23470115 2460:11320034 2389:Archived 2368:Archived 2364:27601641 2356:16479107 2336:Dig Surg 2286:24143122 2235:20632486 2227:23216340 2191:46967845 2133:Archived 2104:15470213 1989:29088907 1981:10092957 1880:Archived 1841:17054249 1810:16296875 1732:(2019). 1716:Archived 1661:34136263 1601:Archived 1571:Archived 1497:DailyMed 1477:30 March 1315:in vitro 1073:Bacillus 857:Outcomes 739:Taxotere 717:(verify) 531:ChEMBL92 422:DrugBank 306:11 hours 176:ATC code 138:category 120:DailyMed 18:Docefrez 5900:Taxanes 5814:Sesamin 5799:Zeranol 5729:Suramin 5499:LOE-908 5191:AMI-193 5105:S-07662 5020:TCPOBOP 4915:Chrysin 3572:S phase 3473:Tegafur 3287:S phase 3212:Taxanes 3148:M phase 2827:Bibcode 2723:6015121 2683:PHARMAC 2636:Bibcode 2598:8913835 2277:3798099 2183:9463787 2054:10 June 2044:Medsafe 1652:8200505 1319:in vivo 941:febrile 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2456:PMID 2419:ISBN 2397:2006 2352:PMID 2282:PMID 2223:PMID 2179:PMID 2141:2006 2100:PMID 2056:2010 1977:PMID 1837:PMID 1806:PMID 1706:ISBN 1679:ISBN 1657:PMID 1609:2016 1579:2016 1534:2020 1505:2020 1479:2024 1453:2023 1424:2020 1368:CNRS 1357:US$ 1317:and 1246:and 765:and 482:KEGG 462:UNII 411:6809 261:data 74:AHFS 5121:PXR 4865:CAR 4441:ERA 4297:PhI 4268:PrI 4233:CDK 4145:PDT 3143:MIs 3139:SPs 3130:L01 2961:doi 2895:PMC 2887:doi 2835:doi 2787:doi 2718:PMC 2710:doi 2654:PMC 2644:doi 2586:doi 2528:doi 2487:doi 2448:doi 2444:108 2344:doi 2272:PMC 2262:doi 2215:doi 2171:doi 2090:doi 2086:351 1969:doi 1829:doi 1798:doi 1738:hdl 1647:PMC 1639:doi 1446:FDA 1370:at 1366:at 1307:GTP 735:DXL 733:or 731:DTX 547:EPA 381:CID 189:WHO 5871:: 4801:: 4321:LI 4221:FI 3687:II 3657:II 3479:)) 3046:. 3014:. 2989:. 2967:. 2957:24 2955:. 2925:. 2903:. 2893:. 2883:10 2881:. 2877:. 2855:^ 2841:. 2833:. 2823:19 2821:. 2809:^ 2795:. 2783:10 2781:. 2777:. 2765:^ 2748:. 2726:. 2716:. 2706:35 2704:. 2700:. 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