234:
211:
108:
133:
240:
139:
1740:
Murza A, Sainsily X, Coquerel D, Côté J, Marx P, Besserer-Offroy É, et al. (April 2016). "Discovery and
Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions".
2184:
Myers, Michael C.; Bilder, Donna M.; Cavallaro, Cullen L.; Chao, Hannguang J.; Su, Shun; Burford, Neil T.; Nayeem, Akbar; Wang, Tao; Yan, Mujing; Langish, Robert A.; Dabros, Marta (2020-04-01).
1443:"International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand"
2127:
Ason, Brandon; Chen, Yinhong; Guo, Qi; Hoagland, Kimberly M.; Chui, Ray W.; Fielden, Mark; Sutherland, Weston; Chen, Rhonda; Zhang, Ying; Mihardja, Shirley; Ma, Xiaochuan (2020-04-23).
1776:
Yi Y, Tsai SH, Cheng JC, Wang EY, Anglesio MS, Cochrane DR, et al. (December 2017). "APELA promotes tumour growth and cell migration in ovarian cancer in a p53-dependent manner".
1913:
Sharma, Bikram; Ho, Lena; Ford, Gretchen Hazel; Chen, Heidi I.; Goldstone, Andrew B.; Woo, Y. Joseph; Quertermous, Thomas; Reversade, Bruno; Red-Horse, Kristy (2017-09-25).
247:
146:
2062:
Ma, Yanbin; Ding, Yao; Song, Xianqiang; Ma, Xiaochuan; Li, Xun; Zhang, Ning; Song, Yunpeng; Sun, Yaping; Shen, Yuqing; Zhong, Wenge; Hu, Liaoyuan A. (January 2020).
1126:
receptor expression are linked to the different functions played by
Elabela in the organism. Despite that, Elabela is capable of signaling independently of
754:
735:
1423:
1405:
1228:
The ELABELA -APLNR signaling axis is required for formation of the coronary vessels of the heart in mice through the sinus venosus progenitors.
2299:
962:
233:
969:
210:
1392:
1371:
1336:
1274:
1388:
132:
107:
1367:
2019:
Xu C (January 2021). "The
Elabela in hypertension, cardiovascular disease, renal disease, and preeclampsia: an update".
57:
1220:
at their cell surface. This participates in the formation of the first and secondary vessels of the vascular system.
246:
145:
1693:"ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury"
1915:"Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts"
1644:"Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts"
1441:
Read C, Nyimanu D, Williams TL, Huggins DJ, Sulentic P, Macrae RG, et al. (October 2019). Ohlstein EH (ed.).
239:
138:
1263:
799:
65:
1114:
and cleavage of the signal peptide, the proprotein of 32 amino acids may generate several active fragments.
780:
1155:
1170:
1111:
2075:
1598:
1325:
660:
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
121:
44:
2186:"Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ"
1862:
Helker CS, Eberlein J, Wilhelm K, Sugino T, Malchow J, Schuermann A, et al. (September 2020).
1321:
1166:
1162:
1143:
1131:
1055:
945:
941:
920:
894:
890:
869:
1178:
2276:
2221:
2044:
1624:
1497:"ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway"
81:
2319:
2309:
2268:
2260:
2213:
2205:
2166:
2148:
2109:
2091:
2064:"Structure-guided discovery of a single-domain antibody agonist against human apelin receptor"
2036:
2001:
1952:
1934:
1895:
1844:
1793:
1758:
1722:
1673:
1616:
1564:
1518:
1472:
37:
2314:
2252:
2197:
2156:
2140:
2099:
2083:
2028:
1991:
1983:
1942:
1926:
1885:
1875:
1834:
1824:
1785:
1750:
1712:
1704:
1663:
1655:
1606:
1554:
1508:
1462:
1454:
326:
257:
201:
156:
77:
1811:
Helker CS, Schuermann A, Pollmann C, Chng SC, Kiefer F, Reversade B, Herzog W (May 2015).
1217:
1209:
1127:
1123:
1091:
1044:
301:
2079:
1602:
1585:
Ho L, van Dijk M, Chye ST, Messerschmidt DM, Chng SC, Ong S, et al. (August 2017).
2304:
2161:
2128:
2104:
2063:
1996:
1971:
1947:
1914:
1890:
1863:
1839:
1812:
1717:
1692:
1668:
1643:
1467:
1442:
1310:
1278:
1270:
1103:
1051:
2256:
1813:"The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis"
1642:
Sharma B, Ho L, Ford GH, Chen HI, Goldstone AB, Woo YJ, et al. (September 2017).
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
594:
589:
584:
579:
574:
569:
564:
559:
543:
538:
522:
517:
2293:
2280:
2225:
2048:
1317:
1313:
agonist capable of mimicking the function of ELA towards it cognate receptor APLNR.
1255:
1237:
1202:
1142:
The
Elabela protein is synthesized, processed and secreted by undifferentiated human
504:
1543:"ELABELA: a hormone essential for heart development signals via the apelin receptor"
69:
1628:
1587:"ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice"
1174:
1146:
but not mouse embryonic stem cells. In humans it is under the direct regulation of
1087:
1075:
319:
98:
1864:"Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state"
2032:
1930:
1754:
1659:
1559:
1542:
85:
1789:
1708:
1428:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1410:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1298:
1282:
1259:
1243:
1198:
1071:
2201:
2144:
1513:
1496:
1495:
Ho L, Tan SY, Wee S, Wu Y, Tan SJ, Ramakrishna NB, et al. (October 2015).
402:
1987:
1332:
1213:
1107:
1059:
218:
115:
2264:
2209:
2152:
2095:
1938:
1285:-like cells, suggesting that it may enhance placental development to prevent
1611:
1586:
1344:
1340:
1286:
1251:
1194:
1190:
1040:
699:
462:
340:
285:
272:
184:
171:
73:
2272:
2240:
2217:
2185:
2170:
2113:
2087:
2040:
2005:
1956:
1899:
1848:
1797:
1762:
1726:
1677:
1620:
1568:
1522:
1476:
1458:
1009:
1004:
1306:
1247:
1063:
993:
844:
825:
1880:
1829:
1025:
811:
766:
1147:
1067:
1036:
977:
721:
1691:
Xu C, Wang F, Chen Y, Xie S, Sng D, Reversade B, Yang T (May 2020).
1302:
1151:
1058:. It is widely expressed in various developing organs such as the
684:
680:
605:
positive regulation of G protein-coupled receptor internalization
1102:
Elabela gene encodes a pre-proprotein of 54 amino acids, with a
1032:
61:
2241:"Reducing maternal mortality: can elabela help in this fight?"
2129:"Cardiovascular response to small-molecule APJ activation"
1328:
has also created its own small molecule agonist of APLNR.
48:, ELA, Ende, tdl, apelin receptor early endogenous ligand
309:
1335:
in 2019 suggested that ELABELA could be used to treat
474:
2239:
Hassan, Sonia S.; Gomez-Lopez, Nardhy (2019-07-06).
1541:
Chng SC, Ho L, Tian J, Reversade B (December 2013).
1316:The latter has entered phase 1 clinical trials for
934:
913:
883:
862:
1384:
1382:
1380:
1363:
1361:
1359:
1189:Elabela is expressed by midline tissues (such as
655:positive regulation of trophoblast cell migration
256:
155:
1697:American Journal of Physiology. Renal Physiology
1297:Several mimetics of ELA have been developed for
570:cell migration involved in mesendoderm migration
1134:and certain cancer cell lines including OVISE.
1389:GRCm38: Ensembl release 89: ENSMUSG00000079042
8:
2190:Bioorganic & Medicinal Chemistry Letters
1169:signalling, endogenous Elabela entrains the
650:positive regulation of ERK1 and ERK2 cascade
1536:
1534:
1532:
1368:GRCh38: Ensembl release 89: ENSG00000248329
1281:mothers. ELA increases the invasiveness of
620:mesoderm migration involved in gastrulation
695:
500:
297:
196:
93:
2160:
2103:
1995:
1946:
1889:
1879:
1838:
1828:
1716:
1667:
1610:
1558:
1512:
1490:
1488:
1486:
1466:
1090:that was identified in 2013 by Professor
610:regulation of signaling receptor activity
635:positive regulation of heart contraction
1355:
16:Mammalian peptide found in Homo sapiens
1976:Trends in Endocrinology and Metabolism
1970:Papangeli I, Chun HJ (November 2017).
18:
1269:Infusion of exogenous ELA normalizes
1110:region. After translocation into the
261:
222:
217:
160:
119:
114:
7:
1580:
1578:
1035:. Elabela is one of two endogenous
595:positive regulation of angiogenesis
931:
910:
880:
859:
835:
816:
790:
771:
745:
726:
560:multicellular organism development
479:
397:
335:
314:
14:
1972:"A Tale of Two Elabela Null Mice"
1258:-like symptoms, characterized by
1028:that in humans is encoded by the
640:placenta blood vessel development
600:apelin receptor signaling pathway
645:coronary vasculature development
630:embryonic heart tube development
590:SMAD protein signal transduction
245:
238:
232:
209:
144:
137:
131:
106:
1337:intrauterine growth restriction
1275:intrauterine growth retardation
1743:Journal of Medicinal Chemistry
1074:, and is circulating in human
463:More reference expression data
371:olfactory zone of nasal mucosa
1:
2257:10.1016/S0140-6736(19)30543-4
230:
129:
2033:10.1097/HJH.0000000000002591
1931:10.1016/j.devcel.2017.08.008
1755:10.1021/acs.jmedchem.5b01549
1660:10.1016/j.devcel.2017.08.008
1560:10.1016/j.devcel.2013.11.002
2300:Genes on human chromosome 4
1790:10.1016/j.ygyno.2017.10.016
1709:10.1152/ajprenal.00606.2019
1242:ELA is a secreted into the
1050:Ela is secreted by certain
1024:(ELA, Apela, Toddler) is a
2336:
2202:10.1016/j.bmcl.2020.126955
2145:10.1172/jci.insight.132898
1514:10.1016/j.stem.2015.08.010
1254:mice lacking Ela, exhibit
1235:
1988:10.1016/j.tem.2017.09.004
1424:"Mouse PubMed Reference:"
1406:"Human PubMed Reference:"
1008:
1003:
999:
992:
976:
957:
938:
917:
906:
887:
866:
855:
842:
838:
823:
819:
810:
797:
793:
778:
774:
765:
752:
748:
733:
729:
720:
705:
698:
694:
678:
503:
499:
487:
482:
473:
460:
413:medullary collecting duct
409:
400:
363:mucosa of paranasal sinus
347:
338:
308:
300:
296:
279:
266:
229:
208:
199:
195:
178:
165:
128:
105:
96:
92:
55:
52:
42:
35:
30:
26:
21:
1331:An opinion published in
1264:gestational hypertension
963:Chr 4: 164.88 – 164.9 Mb
2021:Journal of Hypertension
1612:10.1126/science.aam6607
1447:Pharmacological Reviews
1118:Physiological functions
970:Chr 8: 65.48 – 65.49 Mb
625:adult heart development
523:apelin receptor binding
2088:10.1126/sciadv.aax7379
1138:Embryonic pluripotency
1054:types including human
437:atrioventricular valve
1459:10.1124/pr.119.017533
1208:There it serves as a
1171:PI3K/AKT/mTOR pathway
1112:endoplasmic reticulum
565:mesendoderm migration
367:palpebral conjunctiva
1778:Gynecologic Oncology
1326:Bristol Myers Squibb
1322:acute kidney disease
1305:has created a camel
1277:in pups born to Ela
1144:embryonic stem cells
1132:embryonic stem cells
1056:embryonic stem cells
670:cell differentiation
575:endoderm development
539:extracellular region
224:Chromosome 8 (mouse)
122:Chromosome 4 (human)
2080:2020SciA....6.7379M
1881:10.7554/eLife.55589
1830:10.7554/eLife.06726
1603:2017Sci...357..707H
1201:in mammals) during
544:extracellular space
441:definitive endoderm
425:endocardial cushion
1919:Developmental Cell
1703:(5): F1122–F1135.
1648:Developmental Cell
1547:Developmental Cell
1246:by the developing
800:ENSMUSG00000079042
553:Biological process
532:Cellular component
511:Molecular function
359:buccal mucosa cell
1925:(6): 655–666.e3.
1654:(6): 655–666.e3.
1597:(6352): 707–713.
1092:Bruno Reversade's
1019:
1018:
1015:
1014:
988:
987:
953:
952:
928:
927:
902:
901:
877:
876:
851:
850:
832:
831:
806:
805:
787:
786:
761:
760:
742:
741:
690:
689:
585:heart development
495:
494:
491:
490:
469:
468:
456:
455:
394:
393:
292:
291:
191:
190:
86:APELA - orthologs
2327:
2285:
2284:
2236:
2230:
2229:
2181:
2175:
2174:
2164:
2124:
2118:
2117:
2107:
2068:Science Advances
2059:
2053:
2052:
2016:
2010:
2009:
1999:
1967:
1961:
1960:
1950:
1910:
1904:
1903:
1893:
1883:
1859:
1853:
1852:
1842:
1832:
1808:
1802:
1801:
1773:
1767:
1766:
1737:
1731:
1730:
1720:
1688:
1682:
1681:
1671:
1639:
1633:
1632:
1614:
1582:
1573:
1572:
1562:
1538:
1527:
1526:
1516:
1492:
1481:
1480:
1470:
1438:
1432:
1431:
1420:
1414:
1413:
1402:
1396:
1386:
1375:
1365:
1026:hormonal peptide
1001:
1000:
972:
965:
948:
932:
923:
911:
907:RefSeq (protein)
897:
881:
872:
860:
836:
817:
791:
772:
746:
727:
696:
518:hormone activity
501:
480:
465:
421:primitive streak
405:
403:Top expressed in
398:
343:
341:Top expressed in
336:
315:
298:
288:
275:
264:
249:
242:
236:
225:
213:
197:
187:
174:
163:
148:
141:
135:
124:
110:
94:
88:
47:
40:
19:
2335:
2334:
2330:
2329:
2328:
2326:
2325:
2324:
2290:
2289:
2288:
2238:
2237:
2233:
2183:
2182:
2178:
2126:
2125:
2121:
2074:(3): eaax7379.
2061:
2060:
2056:
2018:
2017:
2013:
1982:(11): 759–760.
1969:
1968:
1964:
1912:
1911:
1907:
1861:
1860:
1856:
1810:
1809:
1805:
1775:
1774:
1770:
1739:
1738:
1734:
1690:
1689:
1685:
1641:
1640:
1636:
1584:
1583:
1576:
1540:
1539:
1530:
1494:
1493:
1484:
1440:
1439:
1435:
1422:
1421:
1417:
1404:
1403:
1399:
1387:
1378:
1366:
1357:
1353:
1295:
1240:
1234:
1226:
1210:chemoattractant
1187:
1140:
1120:
1100:
1084:
1010:View/Edit Mouse
1005:View/Edit Human
968:
961:
958:Location (UCSC)
944:
940:
919:
893:
889:
868:
781:ENSG00000248329
674:
548:
527:
461:
452:
447:
443:
439:
435:
431:
427:
423:
419:
415:
401:
390:
385:
381:
379:skin of abdomen
377:
373:
369:
365:
361:
357:
353:
339:
283:
270:
262:
252:
251:
250:
243:
223:
200:Gene location (
182:
169:
161:
151:
150:
149:
142:
120:
97:Gene location (
56:
43:
36:
17:
12:
11:
5:
2333:
2331:
2323:
2322:
2317:
2312:
2307:
2302:
2292:
2291:
2287:
2286:
2251:(10192): 8–9.
2231:
2176:
2119:
2054:
2011:
1962:
1905:
1854:
1803:
1784:(3): 663–671.
1768:
1749:(7): 2962–72.
1732:
1683:
1634:
1574:
1528:
1501:Cell Stem Cell
1482:
1453:(4): 467–502.
1433:
1415:
1397:
1376:
1354:
1352:
1349:
1311:small molecule
1294:
1291:
1271:blood pressure
1233:
1230:
1225:
1222:
1186:
1183:
1139:
1136:
1119:
1116:
1104:signal peptide
1099:
1096:
1083:
1080:
1045:APLNR receptor
1017:
1016:
1013:
1012:
1007:
997:
996:
990:
989:
986:
985:
983:
981:
974:
973:
966:
959:
955:
954:
951:
950:
936:
935:
929:
926:
925:
915:
914:
908:
904:
903:
900:
899:
885:
884:
878:
875:
874:
864:
863:
857:
853:
852:
849:
848:
840:
839:
833:
830:
829:
821:
820:
814:
808:
807:
804:
803:
795:
794:
788:
785:
784:
776:
775:
769:
763:
762:
759:
758:
750:
749:
743:
740:
739:
731:
730:
724:
718:
717:
712:
707:
703:
702:
692:
691:
688:
687:
676:
675:
673:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
615:vasculogenesis
612:
607:
602:
597:
592:
587:
582:
577:
572:
567:
562:
556:
554:
550:
549:
547:
546:
541:
535:
533:
529:
528:
526:
525:
520:
514:
512:
508:
507:
497:
496:
493:
492:
489:
488:
485:
484:
477:
471:
470:
467:
466:
458:
457:
454:
453:
451:
450:
446:
442:
438:
434:
430:
426:
422:
418:
417:tail of embryo
414:
410:
407:
406:
395:
392:
391:
389:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
345:
344:
332:
331:
323:
312:
306:
305:
302:RNA expression
294:
293:
290:
289:
281:
277:
276:
268:
265:
260:
254:
253:
244:
237:
231:
227:
226:
221:
215:
214:
206:
205:
193:
192:
189:
188:
180:
176:
175:
167:
164:
159:
153:
152:
143:
136:
130:
126:
125:
118:
112:
111:
103:
102:
90:
89:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2332:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2301:
2298:
2297:
2295:
2282:
2278:
2274:
2270:
2266:
2262:
2258:
2254:
2250:
2246:
2242:
2235:
2232:
2227:
2223:
2219:
2215:
2211:
2207:
2203:
2199:
2196:(7): 126955.
2195:
2191:
2187:
2180:
2177:
2172:
2168:
2163:
2158:
2154:
2150:
2146:
2142:
2138:
2134:
2130:
2123:
2120:
2115:
2111:
2106:
2101:
2097:
2093:
2089:
2085:
2081:
2077:
2073:
2069:
2065:
2058:
2055:
2050:
2046:
2042:
2038:
2034:
2030:
2026:
2022:
2015:
2012:
2007:
2003:
1998:
1993:
1989:
1985:
1981:
1977:
1973:
1966:
1963:
1958:
1954:
1949:
1944:
1940:
1936:
1932:
1928:
1924:
1920:
1916:
1909:
1906:
1901:
1897:
1892:
1887:
1882:
1877:
1873:
1869:
1865:
1858:
1855:
1850:
1846:
1841:
1836:
1831:
1826:
1822:
1818:
1814:
1807:
1804:
1799:
1795:
1791:
1787:
1783:
1779:
1772:
1769:
1764:
1760:
1756:
1752:
1748:
1744:
1736:
1733:
1728:
1724:
1719:
1714:
1710:
1706:
1702:
1698:
1694:
1687:
1684:
1679:
1675:
1670:
1665:
1661:
1657:
1653:
1649:
1645:
1638:
1635:
1630:
1626:
1622:
1618:
1613:
1608:
1604:
1600:
1596:
1592:
1588:
1581:
1579:
1575:
1570:
1566:
1561:
1556:
1553:(6): 672–80.
1552:
1548:
1544:
1537:
1535:
1533:
1529:
1524:
1520:
1515:
1510:
1507:(4): 435–47.
1506:
1502:
1498:
1491:
1489:
1487:
1483:
1478:
1474:
1469:
1464:
1460:
1456:
1452:
1448:
1444:
1437:
1434:
1429:
1425:
1419:
1416:
1411:
1407:
1401:
1398:
1394:
1390:
1385:
1383:
1381:
1377:
1373:
1369:
1364:
1362:
1360:
1356:
1350:
1348:
1346:
1342:
1339:and maternal
1338:
1334:
1329:
1327:
1323:
1319:
1318:heart failure
1314:
1312:
1308:
1304:
1300:
1292:
1290:
1288:
1284:
1280:
1276:
1273:and prevents
1272:
1267:
1265:
1261:
1257:
1256:pre-eclampsia
1253:
1249:
1245:
1239:
1238:Pre-eclampsia
1232:Pre-eclampsia
1231:
1229:
1223:
1221:
1219:
1215:
1211:
1206:
1204:
1203:organogenesis
1200:
1196:
1192:
1191:the notochord
1184:
1182:
1180:
1176:
1172:
1168:
1164:
1159:
1157:
1153:
1149:
1145:
1137:
1135:
1133:
1129:
1125:
1122:The sites of
1117:
1115:
1113:
1109:
1105:
1097:
1095:
1093:
1089:
1086:Elabela is a
1081:
1079:
1077:
1073:
1069:
1065:
1061:
1057:
1053:
1048:
1046:
1042:
1038:
1034:
1031:
1027:
1023:
1011:
1006:
1002:
998:
995:
991:
984:
982:
979:
975:
971:
967:
964:
960:
956:
949:
947:
943:
937:
933:
930:
924:
922:
916:
912:
909:
905:
898:
896:
892:
886:
882:
879:
873:
871:
865:
861:
858:
856:RefSeq (mRNA)
854:
847:
846:
841:
837:
834:
828:
827:
822:
818:
815:
813:
809:
802:
801:
796:
792:
789:
783:
782:
777:
773:
770:
768:
764:
757:
756:
751:
747:
744:
738:
737:
732:
728:
725:
723:
719:
716:
713:
711:
708:
704:
701:
697:
693:
686:
682:
677:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
576:
573:
571:
568:
566:
563:
561:
558:
557:
555:
552:
551:
545:
542:
540:
537:
536:
534:
531:
530:
524:
521:
519:
516:
515:
513:
510:
509:
506:
505:Gene ontology
502:
498:
486:
481:
478:
476:
472:
464:
459:
448:
444:
440:
436:
432:
428:
424:
420:
416:
412:
411:
408:
404:
399:
396:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
349:
346:
342:
337:
334:
333:
330:
328:
324:
322:
321:
317:
316:
313:
311:
307:
303:
299:
295:
287:
282:
278:
274:
269:
263:8 B3.1|8
259:
255:
248:
241:
235:
228:
220:
216:
212:
207:
203:
198:
194:
186:
181:
177:
173:
168:
158:
154:
147:
140:
134:
127:
123:
117:
113:
109:
104:
100:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2248:
2244:
2234:
2193:
2189:
2179:
2136:
2132:
2122:
2071:
2067:
2057:
2027:(1): 12–22.
2024:
2020:
2014:
1979:
1975:
1965:
1922:
1918:
1908:
1871:
1867:
1857:
1820:
1816:
1806:
1781:
1777:
1771:
1746:
1742:
1735:
1700:
1696:
1686:
1651:
1647:
1637:
1594:
1590:
1550:
1546:
1504:
1500:
1450:
1446:
1436:
1427:
1418:
1409:
1400:
1330:
1315:
1296:
1293:Therapeutics
1268:
1241:
1227:
1207:
1188:
1179:self-renewal
1175:pluripotency
1173:to maintain
1160:
1141:
1121:
1101:
1098:Biosynthesis
1088:micropeptide
1085:
1049:
1029:
1021:
1020:
946:NP_001386351
942:NP_001284483
939:
921:NP_001284479
918:
895:NM_001399422
891:NM_001297554
888:
870:NM_001297550
867:
843:
824:
798:
779:
753:
734:
714:
709:
665:angiogenesis
580:gastrulation
433:human kidney
429:right kidney
325:
318:
183:164,898,965
170:164,877,178
53:External IDs
2133:JCI Insight
1299:therapeutic
1283:trophoblast
1260:proteinuria
1244:bloodstream
1216:expressing
1214:angioblasts
1199:neural tube
1072:endothelium
387:skin of hip
284:65,489,988
271:65,481,069
31:Identifiers
2294:Categories
1874:: e55589.
1823:: e06726.
1395:, May 2017
1374:, May 2017
1351:References
1343:linked to
1333:the Lancet
1301:purposes.
1236:See also:
1108:N-terminal
1060:blastocyst
329:(ortholog)
2281:195829649
2265:1474-547X
2226:211071546
2210:1464-3405
2153:2379-3708
2096:2375-2548
2049:220944866
1939:1878-1551
1345:eclampsia
1341:morbidity
1287:eclampsia
1195:zebrafish
1167:paracrine
1163:autocrine
1130:in human
1082:Discovery
1066:, heart,
1043:-coupled
1041:G-protein
755:100038489
736:100506013
700:Orthologs
74:GeneCards
2320:Hormones
2310:Peptides
2273:31282362
2218:32035698
2171:32208384
2114:31998837
2041:32740407
2006:28964631
1957:28890073
1900:32955436
1849:26017639
1798:29079036
1763:26986036
1727:32174138
1678:28890073
1621:28663440
1569:24316148
1523:26387754
1477:31492821
1391:–
1370:–
1307:antibody
1279:knockout
1252:Pregnant
1248:placenta
1185:Vascular
1161:Through
1150:(a.k.a.
1064:placenta
1039:for the
994:Wikidata
679:Sources:
383:placenta
375:prostate
355:testicle
2315:Ligands
2162:7205427
2105:6962038
2076:Bibcode
1997:5673578
1948:5895086
1891:7567607
1840:4468421
1718:7294342
1669:5895086
1629:3241807
1599:Bibcode
1591:Science
1468:6731456
1393:Ensembl
1372:Ensembl
1224:Cardiac
1106:in the
1037:ligands
1022:ELABELA
812:UniProt
767:Ensembl
706:Species
685:QuickGO
304:pattern
70:3642370
38:Aliases
2279:
2271:
2263:
2245:Lancet
2224:
2216:
2208:
2169:
2159:
2151:
2112:
2102:
2094:
2047:
2039:
2004:
1994:
1955:
1945:
1937:
1898:
1888:
1847:
1837:
1796:
1761:
1725:
1715:
1676:
1666:
1627:
1619:
1567:
1521:
1475:
1465:
1309:and a
1154:) and
1148:POU5F1
1094:team.
1076:plasma
1068:kidney
980:search
978:PubMed
845:P0DMC4
826:P0DMC3
722:Entrez
475:BioGPS
445:embryo
162:4q32.3
62:615594
2305:Genes
2277:S2CID
2222:S2CID
2139:(8).
2045:S2CID
1868:eLife
1817:eLife
1625:S2CID
1303:Amgen
1218:APLNR
1156:NANOG
1128:APLNR
1124:APLNR
1030:APELA
715:Mouse
710:Human
681:Amigo
351:tibia
327:Mouse
320:Human
267:Start
202:Mouse
166:Start
99:Human
78:APELA
45:APELA
22:APELA
2269:PMID
2261:ISSN
2214:PMID
2206:ISSN
2167:PMID
2149:ISSN
2110:PMID
2092:ISSN
2037:PMID
2002:PMID
1953:PMID
1935:ISSN
1896:PMID
1845:PMID
1794:PMID
1759:PMID
1723:PMID
1674:PMID
1617:PMID
1565:PMID
1519:PMID
1473:PMID
1320:and
1262:and
1197:and
1177:and
1165:and
1152:OCT4
1052:cell
1033:gene
449:hand
310:Bgee
258:Band
219:Chr.
157:Band
116:Chr.
58:OMIM
2253:doi
2249:394
2198:doi
2157:PMC
2141:doi
2100:PMC
2084:doi
2029:doi
1992:PMC
1984:doi
1943:PMC
1927:doi
1886:PMC
1876:doi
1835:PMC
1825:doi
1786:doi
1782:147
1751:doi
1713:PMC
1705:doi
1701:318
1664:PMC
1656:doi
1607:doi
1595:357
1555:doi
1509:doi
1463:PMC
1455:doi
1212:to
1193:in
1070:,
483:n/a
280:End
179:End
82:OMA
66:MGI
2296::
2275:.
2267:.
2259:.
2247:.
2243:.
2220:.
2212:.
2204:.
2194:30
2192:.
2188:.
2165:.
2155:.
2147:.
2135:.
2131:.
2108:.
2098:.
2090:.
2082:.
2070:.
2066:.
2043:.
2035:.
2025:39
2023:.
2000:.
1990:.
1980:28
1978:.
1974:.
1951:.
1941:.
1933:.
1923:42
1921:.
1917:.
1894:.
1884:.
1870:.
1866:.
1843:.
1833:.
1819:.
1815:.
1792:.
1780:.
1757:.
1747:59
1745:.
1721:.
1711:.
1699:.
1695:.
1672:.
1662:.
1652:42
1650:.
1646:.
1623:.
1615:.
1605:.
1593:.
1589:.
1577:^
1563:.
1551:27
1549:.
1545:.
1531:^
1517:.
1505:17
1503:.
1499:.
1485:^
1471:.
1461:.
1451:71
1449:.
1445:.
1426:.
1408:.
1379:^
1358:^
1347:.
1324:.
1289:.
1266:.
1250:.
1205:.
1181:.
1158:.
1078:.
1062:,
1047:.
683:/
286:bp
273:bp
185:bp
172:bp
80:;
76::
72:;
68::
64:;
60::
2283:.
2255::
2228:.
2200::
2173:.
2143::
2137:5
2116:.
2086::
2078::
2072:6
2051:.
2031::
2008:.
1986::
1959:.
1929::
1902:.
1878::
1872:9
1851:.
1827::
1821:4
1800:.
1788::
1765:.
1753::
1729:.
1707::
1680:.
1658::
1631:.
1609::
1601::
1571:.
1557::
1525:.
1511::
1479:.
1457::
1430:.
1412:.
204:)
101:)
84::
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