775:(OA) with a subcutaneous injection. The 3 mg/kg dose was the most effective. In a study conducted with 10 elderly dogs with osteoarthritis given calcium pentosan polysulfate (3 mg/kg intramuscularly) once weekly for four weeks, the improvement in symptoms (seen at 1, 2, 3 and 7 weeks after initiation of therapy) was found to correlate with plasma indices of fibrinolytic activity and lipid profiles. In a study in dogs with OA secondary to cranial cruciate ligament deficiency, although no differences were identified in either functional outcome or radiographic progression using the oral calcium pentosan polysulfate compared with placebo, there were significantly lower levels of
447:
42:
2303:
1614:
520:
716:
Various brand names include
Elmiron (as sodium salt), Hemoclar, Anarthron, Fibrase, Fibrocid, Thrombocid and SP54. Pentosan polysulfate capsules are sold in India under the brand names Comfora, Pentossan-100, Cystopen and For-IC. In the veterinary field, pentosan polysulfate is sold as Cartrophen Vet
813:
Pentosan polysulfate is being used for this osteoarthritis in
Australia. When administered to racing thoroughbreds with chronic osteoarthritis (2 to 3 mg/kg, intramuscularly, once weekly for 4 weeks, then as required), pentosan polysulfate treatment improved but did not eliminate clinical signs
652:
have also been reported. Due to
Elmiron's anticoagulant effects, some patients report bruising more easily. In some cases, patients are asked to stop taking the medication before any major surgical procedures to reduce the likelihood of bleeding. Recent report based on clinical observation
810:(FDA) approved pentosan polysulfate (Zycosan) for the control of clinical signs associated with osteoarthritis in horses. Zycosan is for intramuscular use in horses only and is not for use in humans. Zycosan is sponsored by Anzac Animal Health LLC, based in Maryland Heights, Missouri.
1548:
Budsberg SC, Bergh MS, Reynolds LR, Streppa HK (April 2007). "Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial".
750:
without affecting the normal cellular isoform. As pentosan polysulfate can bind to the cellular isoform of the prion protein, it may stabilise this form and prevent its conversion to the pathological (scrapie) isoform.
562:
InChI=1S/C10H18O21S4/c11-3-1-26-10(8(31-35(22,23)24)5(3)28-32(13,14)15)27-4-2-25-9(12)7(30-34(19,20)21)6(4)29-33(16,17)18/h3-12H,1-2H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)/t3-,4-,5+,6+,7-,8-,9-,10+/m1/s1
1271:"Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells"
746:(CJD). The rationale for this treatment was unclear but it was subsequently shown in prion-infected mouse neuroblastoma cells that pentosan polysulfate could rapidly reduce the levels of abnormal (scrapie)
1504:
Innes JF, Barr AR, Sharif M (April 2000). "Efficacy of oral calcium pentosan polysulphate for the treatment of osteoarthritis of the canine stifle joint secondary to cranial cruciate ligament deficiency".
2071:
814:
of joint disease. Articular cartilage fibrillation was substantially reduced by similar NaPPS treatment intramuscularly in nine horses with experimentally-induced carpal osteoarthritis.
138:
2323:
2064:
2057:
72:
534:
1150:
Hannon RL, Smith JG, Cullis-Hill D, Ghosh P, Cawdery MJ (May 2003). "Safety of
Cartrophen Vet in the dog: review of adverse reaction reports in the UK".
771:
Read et al. (1996) used three different doses of sodium pentosan polysulfate to treat 40 geriatric dogs with well-established clinical signs of chronic
1705:
1377:
Whittle IR, Knight RS, Will RG (June 2006). "Unsuccessful intraventricular pentosan polysulphate treatment of variant
Creutzfeldt-Jakob disease".
1591:
2328:
713:
including BAY-946, HOE-946, pentosan sulfuric polyester, polypentose sulfate, polysulfated xylan, PZ-68, SP-54, xylan SP54 and xylan sulfate.
1648:"Evaluation of intramuscularly administered sodium pentosan polysulfate for treatment of experimentally induced osteoarthritis in horses"
1234:
Ghosh P (February 1999). "The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment".
2333:
554:
783:
of the osteoarthritic joints. The efficacy of subcutaneous sodium pentosan polysulfate (3 mg/kg) was tested in 40 dogs with
840:
109:
208:
90:
1330:"Characterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones"
743:
1434:
Read RA, Cullis-Hill D, Jones MP (March 1996). "Systemic use of pentosan polysulphate in the treatment of osteoarthritis".
799:
Zycosan, for horses, is a heparin-like compound and is the first injectable pentosan product to receive approval by the US
1698:
1597:
807:
800:
717:
and Sylvet by
Biopharm Australia, Pentosan by Naturevet Australia, Anarthron by Randlab Australia and Zydax by Parnell.
349:
689:
The calcium salt of pentosan polysulfate was one of the first reported disease-modifying osteoarthritis drugs (DMOAD).
426:
665:
In interstitial cystitis, pentosan polysulfate is believed to work by providing a protective coating to the damaged
2293:
625:
918:
734:, though evidence to support such use is poor as of 2003. There is some theoretical evidence that it should help.
1937:
784:
1691:
1922:
131:
120:
2230:
1777:
415:
407:
2124:
788:
601:
968:
Parsons CL (February 1994). "The therapeutic role of sulfated polysaccharides in the urinary bladder".
2225:
1932:
1282:
442:
2255:
1049:
Hanif AM, Armenti ST, Taylor SC, Shah RA, Igelman AD, Jayasundera KT, et al. (November 2019).
256:
2250:
2143:
1960:
1530:
1402:
1031:
900:
1051:"Phenotypic Spectrum of Pentosan Polysulfate Sodium-Associated Maculopathy: A Multicenter Study"
624:
Patients who have taken pentosan polysulfate orally report a variety of side effects, primarily
2049:
2270:
2198:
2101:
1669:
1566:
1522:
1486:
1451:
1394:
1359:
1310:
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1216:
1167:
1080:
1023:
985:
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670:
223:
54:
2106:
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1514:
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1443:
1386:
1349:
1341:
1300:
1290:
1243:
1206:
1198:
1159:
1070:
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1015:
977:
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463:
273:
233:
366:
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338:
265:
2307:
2265:
2138:
1762:
191:
181:
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446:
1286:
943:
2116:
1894:
1738:
1714:
1447:
1354:
1329:
1305:
1270:
1211:
1186:
1163:
1075:
1050:
780:
772:
755:
731:
1247:
981:
887:
870:
2317:
2119:
1772:
1767:
1757:
1618:
1562:
1066:
904:
33:
1534:
1406:
1035:
616:
for the relief of bladder pain or discomfort associated with interstitial cystitis.
41:
2158:
2148:
2084:
1864:
1782:
1752:
1718:
776:
186:
176:
166:
161:
156:
151:
146:
1124:
1098:
298:
67:
PPS, (1->4)-β-Xylan 2,3-bis(hydrogen sulfate) with a 4 O-methyl-α-D-glucuronate
1295:
2275:
2193:
2183:
2178:
2163:
2133:
2029:
1996:
1927:
1850:
1817:
1420:
82:
787:
instability and found to hasten recovery, as measured by more rapidly improved
2245:
2188:
2173:
2168:
2034:
2006:
1889:
1879:
1832:
1827:
1812:
1807:
1727:
1390:
1328:
Kamatari YO, Hayano Y, Yamaguchi K, Hosokawa-Muto J, Kuwata K (January 2013).
1019:
678:
597:
496:
329:
1469:
Ghosh P, Cheras PA (December 2001). "Vascular mechanisms in osteoarthritis".
1006:
Ghosh P, Smith M (2002). "Osteoarthritis, genetic and molecular mechanisms".
758:
and around six other patients in mainland
Britain was reported in the press.
2280:
2153:
2093:
2011:
1982:
1802:
706:
name for pentosan polysulfate is oxy-3-sulfooxyoxan-4-yl] hydrogen sulfate.
633:
613:
241:
76:
1673:
1570:
1526:
1490:
1482:
1398:
1363:
1314:
1255:
1220:
1202:
1171:
1084:
1027:
896:
1664:
1647:
1518:
1455:
989:
2240:
2203:
1822:
1747:
649:
641:
637:
629:
309:
127:
104:
1683:
318:
2080:
2001:
1899:
1875:
710:
674:
666:
284:
17:
1942:
1592:"FDA Approves First Injectable Pentosan for Osteoarthritis in Horses"
1345:
654:
653:
hypothesizes that chronic exposure to pentosan polysulfate can cause
398:
387:
1991:
747:
742:
Pentosan polysulfate is being studied as a potential treatment of
703:
669:
wall. Pentosan polysulfate is similar in structure to the natural
519:
510:
1617:
This article incorporates text from this source, which is in the
2220:
645:
604:. It was approved for medical use in the United States in 1996.
377:
2053:
1687:
542:
O1CO(O2CO(O)(OS(O)(=O)=O)2OS(O)(=O)=O)(OS(O)(=O)=O)1OS(O)(=O)=O
217:
99:
841:"Elmiron- pentosan polysulfate sodium capsule, gelatin coated"
1631:
Little CB, Ghosh P (1996). McIlwraith CW, Trotter GW (eds.).
431:
709:
There are 40 synonyms listed for pentosan polysulfate on
928:. U.S. Food and Drug Administration. 25 September 1996.
579:
1635:. Philadelphia: WB Saunders Company. pp. 281–292.
2291:
677:, and may replace or repair the lining, reducing its
2212:
2115:
2092:
2020:
1980:
1973:
1951:
1913:
1873:
1863:
1841:
1791:
1736:
1726:
1471:
Best
Practice & Research. Clinical Rheumatology
1269:Yamasaki T, Suzuki A, Hasebe R, Horiuchi M (2014).
835:
833:
831:
829:
827:
508:
495:
462:
457:
425:
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348:
328:
308:
283:
255:
250:
240:
232:
207:
202:
137:
119:
89:
71:
63:
53:
48:
657:toxicity, mimicking pigmentary pattern dystrophy.
1646:McIlwraith CW, Frisbie DD, Kawcak CE (May 2012).
1185:Uthman I, Raynauld JP, Haraoui B (August 2003).
297:
272:
264:
1586:
1584:
1582:
1580:
1001:
999:
937:
935:
864:
862:
730:Pentosan polysulfate has been studied in knee
2065:
1699:
963:
961:
8:
108:
32:
1187:"Intra-articular therapy in osteoarthritis"
190:
180:
170:
2324:Drugs acting on the musculoskeletal system
2072:
2058:
2050:
1977:
1870:
1733:
1706:
1692:
1684:
1423:. 1 March 2005 – via news.bbc.co.uk.
869:Lindeke-Myers A, Hanif AM, Jain N (2022).
445:
337:
1663:
1353:
1304:
1294:
1210:
1074:
886:
738:Transmissible spongiform encephalopathies
365:
357:
2298:
1652:American Journal of Veterinary Research
919:"Elmiron (pentosan polysulfate sodium)"
823:
559:
539:
441:
317:
31:
1915:sclerosing agents for local injection
970:The Urologic Clinics of North America
414:
406:
81:
7:
1436:The Journal of Small Animal Practice
1236:Seminars in Arthritis and Rheumatism
1152:The Journal of Small Animal Practice
160:
150:
1421:"Research will now assess CJD drug"
1131:. U.S. National Library of Medicine
1105:. U.S. National Library of Medicine
946:. U.S. National Library of Medicine
673:coating of the inner lining of the
386:
288:
1448:10.1111/j.1748-5827.1996.tb02355.x
1164:10.1111/j.1748-5827.2003.tb00144.x
871:"Pentosan polysulfate maculopathy"
25:
888:10.1016/j.survophthal.2021.05.005
2301:
1612:
1563:10.1111/j.1532-950x.2007.00256.x
1067:10.1001/jamaophthalmol.2019.3392
474:
40:
756:one patient in Northern Ireland
612:Pentosan polysulfate sodium is
567:Key:FCCNSUIJIOOXEZ-SJYYZXOBSA-N
486:
480:
468:
1:
2329:Urologic pelvic pain syndrome
1248:10.1016/s0049-0172(99)80021-3
982:10.1016/S0094-0143(21)00597-8
2083:, including antispasmodics (
1974:Capillary stabilising agents
1598:Food and Drug Administration
1385:(6): 677–9, discussion 679.
1296:10.1371/journal.pone.0106516
1191:Postgraduate Medical Journal
808:Food and Drug Administration
801:Food and Drug Administration
592:, sold under the brand name
626:gastrointestinal complaints
2350:
1633:Joint Disease in the Horse
779:breakdown products in the
600:used for the treatment of
458:Chemical and physical data
2334:IARC Group 2B carcinogens
1938:Sodium tetradecyl sulfate
1391:10.1007/s00701-006-0772-y
806:In December 2022, the US
785:cranial cruciate ligament
744:Creutzfeldt–Jakob disease
575:
550:
530:
39:
1923:Monoethanolamine oleate
1020:10.1023/a:1015219716583
875:Survey of Ophthalmology
2231:Salicylhydroxamic acid
1778:Fluocinolone acetonide
1483:10.1053/berh.2001.0188
1203:10.1136/pmj.79.934.449
1125:"Pentosan polysulfate"
1099:"Pentosan polysulfate"
944:"Pentosan Polysulfate"
942:Pubmed Health (2012).
789:ground reaction forces
1665:10.2460/ajvr.73.5.628
1519:10.1136/vr.146.15.433
1507:The Veterinary Record
602:interstitial cystitis
2261:Pentosan polysulfate
2226:Acetohydroxamic acid
1933:Inverted sugar syrup
1905:Pentosan polysulfate
1379:Acta Neurochirurgica
636:, and stomach pain.
590:Pentosan polysulfate
110:pentosan polysulfate
34:Pentosan polysulfate
2256:Magnesium hydroxide
1287:2014PLoSO...9j6516Y
926:FDA approval letter
693:Society and culture
661:Mechanism of action
596:among others, is a
36:
2251:Dimethyl sulfoxide
1961:Calcium dobesilate
1602:. 20 December 2022
1551:Veterinary Surgery
1055:JAMA Ophthalmology
847:. 10 November 2022
2289:
2288:
2271:Phenyl salicylate
2213:Other urologicals
2199:Trospium chloride
2102:Ammonium chloride
2047:
2046:
2043:
2042:
1969:
1968:
1890:Organo-heparinoid
1859:
1858:
1794:local anesthetics
1728:Antihemorrhoidals
1061:(11): 1275–1282.
791:, over 48 weeks.
754:The treatment of
671:glycosaminoglycan
587:
586:
521:Interactive image
427:CompTox Dashboard
221:
102:
27:Chemical compound
16:(Redirected from
2341:
2306:
2305:
2304:
2297:
2107:Calcium chloride
2074:
2067:
2060:
2051:
1978:
1871:
1734:
1708:
1701:
1694:
1685:
1678:
1677:
1667:
1643:
1637:
1636:
1628:
1622:
1616:
1615:
1611:
1609:
1607:
1588:
1575:
1574:
1545:
1539:
1538:
1501:
1495:
1494:
1466:
1460:
1459:
1431:
1425:
1424:
1417:
1411:
1410:
1374:
1368:
1367:
1357:
1346:10.1002/pro.2180
1325:
1319:
1318:
1308:
1298:
1266:
1260:
1259:
1231:
1225:
1224:
1214:
1197:(934): 449–453.
1182:
1176:
1175:
1147:
1141:
1140:
1138:
1136:
1121:
1115:
1114:
1112:
1110:
1095:
1089:
1088:
1078:
1046:
1040:
1039:
1003:
994:
993:
965:
956:
955:
953:
951:
939:
930:
929:
923:
915:
909:
908:
890:
866:
857:
856:
854:
852:
837:
583:
582:
523:
503:
488:
482:
476:
470:
450:
449:
435:
433:
418:
413:as sodium:
410:
390:
385:as sodium:
369:
364:as sodium:
361:
341:
321:
301:
291:
290:
276:
271:as sodium:
268:
219:
216:
194:
184:
174:
164:
154:
112:
101:
98:
85:
59:Elmiron, Zycosan
44:
37:
35:
21:
2349:
2348:
2344:
2343:
2342:
2340:
2339:
2338:
2314:
2313:
2312:
2302:
2300:
2292:
2290:
2285:
2266:Phenazopyridine
2208:
2139:Desfesoterodine
2125:antimuscarinics
2122:
2111:
2088:
2078:
2048:
2039:
2016:
1965:
1947:
1909:
1882:for topical use
1855:
1837:
1787:
1763:Fluorometholone
1739:corticosteroids
1730:for topical use
1722:
1715:Vasoprotectives
1712:
1682:
1681:
1645:
1644:
1640:
1630:
1629:
1625:
1613:
1605:
1603:
1590:
1589:
1578:
1547:
1546:
1542:
1513:(15): 433–437.
1503:
1502:
1498:
1468:
1467:
1463:
1433:
1432:
1428:
1419:
1418:
1414:
1376:
1375:
1371:
1334:Protein Science
1327:
1326:
1322:
1268:
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1263:
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949:
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917:
916:
912:
868:
867:
860:
850:
848:
839:
838:
825:
820:
797:
769:
764:
762:Veterinary uses
740:
728:
723:
700:
695:
687:
663:
622:
620:Adverse effects
610:
578:
576:
571:
568:
563:
558:
557:
546:
543:
538:
537:
526:
501:
491:
485:
479:
473:
453:
429:
421:
393:
372:
344:
324:
304:
287:
279:
234:Pharmacokinetic
228:
198:
122:
115:
28:
23:
22:
15:
12:
11:
5:
2347:
2345:
2337:
2336:
2331:
2326:
2316:
2315:
2311:
2310:
2287:
2286:
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2283:
2278:
2273:
2268:
2263:
2258:
2253:
2248:
2243:
2234:
2233:
2228:
2216:
2214:
2210:
2209:
2207:
2206:
2201:
2196:
2191:
2186:
2181:
2176:
2171:
2166:
2161:
2156:
2151:
2146:
2141:
2136:
2130:
2128:
2120:antispasmodics
2113:
2112:
2110:
2109:
2104:
2098:
2096:
2090:
2089:
2079:
2077:
2076:
2069:
2062:
2054:
2045:
2044:
2041:
2040:
2038:
2037:
2032:
2026:
2024:
2018:
2017:
2015:
2014:
2009:
2004:
1999:
1994:
1988:
1986:
1975:
1971:
1970:
1967:
1966:
1964:
1963:
1957:
1955:
1949:
1948:
1946:
1945:
1940:
1935:
1930:
1925:
1919:
1917:
1911:
1910:
1908:
1907:
1902:
1897:
1895:Sodium apolate
1892:
1886:
1884:
1868:
1861:
1860:
1857:
1856:
1854:
1853:
1847:
1845:
1839:
1838:
1836:
1835:
1830:
1825:
1820:
1815:
1810:
1805:
1799:
1797:
1789:
1788:
1786:
1785:
1780:
1775:
1770:
1765:
1760:
1755:
1750:
1748:Hydrocortisone
1744:
1742:
1731:
1724:
1723:
1713:
1711:
1710:
1703:
1696:
1688:
1680:
1679:
1658:(5): 628–633.
1638:
1623:
1576:
1557:(3): 234–244.
1540:
1496:
1477:(5): 693–709.
1461:
1442:(3): 108–114.
1426:
1412:
1369:
1320:
1281:(9): e106516.
1261:
1242:(4): 211–267.
1226:
1177:
1158:(5): 202–208.
1142:
1116:
1090:
1041:
1014:(1–2): 85–88.
1008:Biogerontology
995:
957:
931:
910:
858:
822:
821:
819:
816:
796:
793:
781:synovial fluid
773:osteoarthritis
768:
765:
763:
760:
739:
736:
732:osteoarthritis
727:
726:Osteoarthritis
724:
722:
719:
699:
696:
694:
691:
686:
683:
662:
659:
621:
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1983:bioflavonoids
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1773:Dexamethasone
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1768:Fluocortolone
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494:
467:
465:
461:
456:
448:
444:
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439:
437:
428:
424:
417:
416:ChEMBL1201516
412:
409:
408:ChEMBL4073796
405:
404:
402:
400:
396:
389:
384:
383:
381:
379:
375:
368:
363:
360:
356:
355:
353:
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183:
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148:
145:
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136:
133:
132:intramuscular
129:
126:
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118:
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97:
96:
94:
92:
88:
84:
80:
78:
74:
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62:
58:
56:
52:
49:Clinical data
47:
43:
38:
30:
19:
2260:
2237:
2219:
2159:Imidafenacin
2149:Fesoterodine
2021:
1981:
1952:
1914:
1904:
1874:
1865:Antivaricose
1842:
1792:
1783:Fluocinonide
1753:Prednisolone
1737:
1655:
1651:
1641:
1632:
1626:
1604:. Retrieved
1595:
1554:
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1499:
1474:
1470:
1464:
1439:
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1323:
1278:
1274:
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1235:
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948:. Retrieved
925:
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849:. Retrieved
844:
812:
805:
798:
777:proteoglycan
770:
753:
741:
729:
715:
708:
701:
688:
679:permeability
664:
623:
611:
608:Medical uses
593:
589:
588:
577:
246:Feces, urine
209:Legal status
203:Legal status
91:License data
29:
2276:Succinimide
2194:Tolterodine
2184:Solifenacin
2179:Propiverine
2164:Meladrazine
2134:Darifenacin
2123:(primarily
2081:Urologicals
2030:Tribenoside
1997:Monoxerutin
1928:Polidocanol
1880:heparinoids
1851:Tribenoside
1606:21 December
851:21 December
504: g·mol
274:140207-93-8
251:Identifiers
64:Other names
55:Trade names
2318:Categories
2246:Dapoxetine
2223:analogues:
2189:Terodiline
2174:Oxybutynin
2169:Mirabegron
2144:Emepronium
2094:Acidifiers
2035:Etamsylate
2007:Troxerutin
1833:Pramocaine
1828:Oxetacaine
1813:Benzocaine
1808:Tetracaine
1135:8 November
1109:8 November
818:References
598:medication
509:3D model (
497:Molar mass
367:914032762Y
359:F59P8B75R4
330:ChemSpider
266:37300-21-3
257:CAS Number
2281:Tiopronin
2154:Flavoxate
2012:Hidrosmin
1818:Dibucaine
1803:Lidocaine
950:2 October
905:234767956
638:Hair loss
634:heartburn
614:indicated
242:Excretion
121:Routes of
83:Monograph
77:Drugs.com
2308:Medicine
2241:Collagen
2204:Vibegron
1992:Rutoside
1876:heparins
1823:Procaine
1674:22533393
1571:17461948
1535:46623547
1527:10811265
1491:11812016
1407:37400744
1399:16598408
1364:23081827
1315:25181483
1275:PLOS ONE
1256:10073500
1221:12954956
1172:12779171
1085:31486843
1036:33755966
1028:12014849
897:34000253
845:DailyMed
721:Research
650:insomnia
642:headache
630:diarrhea
628:such as
580:(verify)
310:DrugBank
187:QM01AX90
177:QG04BX15
167:QC05BA04
139:ATC code
128:By mouth
105:DailyMed
2117:Urinary
2002:Diosmin
1900:Heparin
1867:therapy
1456:8683953
1355:3575857
1306:4152300
1283:Bibcode
1212:1742771
1129:PubChem
1103:PubChem
1076:6735406
990:7904388
803:(FDA).
711:PubChem
685:History
675:bladder
667:bladder
655:retinal
594:Elmiron
464:Formula
319:DB00686
285:PubChem
189: (
179: (
169: (
159: (
157:G04BX15
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648:, and
535:SMILES
502:602.47
399:ChEMBL
388:D05428
224:℞-only
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2022:other
1953:other
1843:other
1600:(FDA)
1596:U.S.
1531:S2CID
1403:S2CID
1032:S2CID
922:(PDF)
901:S2CID
748:prion
704:IUPAC
698:Names
555:InChI
511:JSmol
339:34595
299:37720
2221:Urea
2085:G04B
1670:PMID
1608:2022
1567:PMID
1523:PMID
1487:PMID
1452:PMID
1395:PMID
1360:PMID
1311:PMID
1252:PMID
1217:PMID
1168:PMID
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1111:2022
1081:PMID
1024:PMID
986:PMID
952:2012
893:PMID
853:2022
767:Dogs
702:The
646:rash
378:KEGG
350:UNII
236:data
73:AHFS
1878:or
1719:C05
1660:doi
1559:doi
1515:doi
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1444:doi
1387:doi
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1350:PMC
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1301:PMC
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1207:PMC
1199:doi
1160:doi
1071:PMC
1063:doi
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1016:doi
978:doi
883:doi
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