600:
577:
40:
31:
4004:
893:
Neostigmine has a wide variety of side-effects due to its action that increases acetylcholine (ACh) binding muscarinic receptors on exocrine glandular cells throughout the body, cardiac muscle cells, and smooth muscle cells. These effects include: salivation, lacrimation, diarrhea, bradycardia, and
980:
shows a second twitch is present or when the first twitch response is considerably above 10% of baseline. Peak effect is at 7 to 10 minutes. Neostigmine has moderate duration of action – usually two to four hours. It is metabolized by enzymes in the liver and excreted in the urine.
1012:
reveals shifts at: 7.8, 7.7, 7.4, 7.4, 3.8, and 3.1 parts per million. The higher shifts are due to the aromatic hydrogens. The lower shifts at 3.8 ppm and 3.1 ppm are due to the electronic withdrawing nature of the tertiary and quaternary nitrogen, respectively.
1651:
Abdelaal Ahmed
Mahmoud A, Mansour AZ, Yassin HM, Hussein HA, Kamal AM, Elayashy M, et al. (December 2018). "Addition of Neostigmine and Atropine to Conventional Management of Postdural Puncture Headache: A Randomized Controlled Trial".
2308:
941:
receptors. Its action leads to the accumulation of acetylcholine in the neuromuscular junction that compete with the non-depolarizing blocker agent bound to the acetylcholine receptors. By interfering with the breakdown of
912:
Neostigmine can also induce generic ocular side effects including: headache, brow pain, blurred vision, phacodonesis, pericorneal injection, congestive iritis, various allergic reactions, and rarely, retinal detachment.
1600:
1737:
Ferdous AJ, Waigh RD (June 1993). "Application of the WATR technique for water suppression in 1H NMR spectroscopy in determination of the kinetics of hydrolysis of neostigmine bromide in aqueous solution".
2301:
1892:
1817:
2742:
239:
2788:
1483:
2294:
925:
that cleaves acetylcholine in the neuromuscular junction into acetate and choline. Neostigmine is an inhibitor of acetylcholinesterase. Neostigmine binds to the anionic and ester site of
4049:
3976:
174:
727:
3981:
1885:
1878:
62:
885:. Some promising research results have also been reported for administering the drug nasally in order to buy time if anti-venom is not immediately available.
683:
1309:
1267:
669:
1491:
4024:
2933:
2403:
1028:-dimethylcarbamoyl chloride, which forms a dimethylcarbamate. Next, that product is alkylated using dimethyl sulfate, which forms neostigmine.
4044:
1796:
818:
1433:
3855:
3768:
1225:
3824:
2628:
1122:
1219:
1166:
1009:
955:
768:
703:
2413:
1788:
4034:
2908:
951:
1071:
354:
224:
80:
2447:
2018:
2373:
3123:
3994:
2423:
989:
Neostigmine, which can be viewed as a simplified analog of physostigmine, is made by reacting 3-dimethylaminophenol with
4039:
4029:
3971:
3710:
2324:
2070:
1303:
468:
2408:
99:
2918:
2040:
556:
2418:
3603:
3581:
1434:"The effectiveness of parasympathomimetics for treating underactive bladder: A systematic review and meta-analysis"
2383:
2368:
2352:
1239:
1144:
977:
2388:
1297:
3798:
3451:
3348:
3073:
2098:
1962:
1952:
1275:
167:
1021:
Neostigmine was first synthesized by
Aeschlimann and Reinert in 1931 and was patented by Aeschlimann in 1933.
966:
2378:
864:
143:
136:
1847:
595:
2264:
2204:
2177:
2076:
970:
780:
767:
without the presence of a blockage. It is also used in anaesthesia to end the effects of non-depolarising
151:
1870:
3716:
3637:
938:
545:
3881:
3877:
3873:
3869:
3846:
3842:
877:
Hospitals sometimes administer a solution containing neostigmine intravenously to delay the effects of
1812:
3566:
2913:
2433:
2393:
2214:
2094:
1919:
1859:
926:
922:
807:
313:
2286:
993:-dimethylcarbamoyl chloride, which forms the dimethylcarbamate, and its subsequent alkylation using
909:
which act only on muscarinic receptors while permitting neostigmine action at nicotinic receptors.
871:, in which patients get massive colonic dilatation in the absence of a true mechanical obstruction.
3727:
3693:
3627:
3556:
3373:
3323:
2848:
2648:
2506:
2208:
2194:
2113:
1936:
572:
375:
155:
147:
3433:
3429:
3425:
3421:
2658:
2615:
2566:
3444:
3148:
3043:
2620:
2486:
2327:
2228:
2026:
1763:
1677:
1596:
1464:
1182:
830:
795:
791:
110:
72:
2601:
2501:
3612:
3293:
3278:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
2777:
2717:
2707:
2571:
2471:
1616:
Howard J, Wigley J, Rosen G, D'mello J (February 2017). "Glycopyrrolate: It's time to review".
3900:
3896:
3838:
3815:
3804:
3358:
3343:
3218:
3168:
3118:
2998:
2798:
1792:
1755:
1719:
1669:
1633:
1565:
1538:
1507:"Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite"
1456:
1414:
1347:
1215:
1209:
1162:
842:
764:
756:
265:
252:
52:
3103:
2591:
1782:
525:
3930:
3911:
3607:
3408:
3403:
3398:
3393:
3388:
3383:
3378:
3298:
3183:
3063:
3053:
2883:
2341:
1747:
1661:
1625:
1592:
1588:
1528:
1518:
1448:
1404:
1396:
1247:
1152:
994:
898:
868:
760:
612:
326:
275:
39:
3058:
1118:
783:. After injection effects are generally greatest within 30 minutes and last up to 4 hours.
477:
4008:
3865:
3834:
3748:
3743:
3551:
2838:
2828:
2808:
1005:
Neostigmine shows notable UV/VIS absorption at 261 nm, 267 nm, and 225 nm.
849:
787:
457:
303:
293:
283:
207:
965:, neostigmine has a quaternary nitrogen; hence, it is more polar. It does not cross the
599:
576:
384:
3466:
3158:
3078:
2833:
2803:
2643:
1751:
1533:
1506:
1409:
1384:
1365:
906:
846:
4018:
3536:
3368:
3143:
3108:
2983:
2638:
2317:
2119:
2104:
2085:
2050:
2031:
2003:
1927:
1835:
1468:
1432:
Moro C, Phelps C, Veer V, Clark J, Glasziou P, Tikkinen KA, Scott AM (January 2022).
1268:"neostigmine: definition of neostigmine in Oxford dictionary (American English) (US)"
962:
943:
934:
826:
811:
776:
588:
1767:
1681:
3892:
3683:
3576:
3531:
3496:
3486:
3481:
3328:
3208:
3113:
3018:
2843:
2653:
2536:
2521:
2255:
2157:
2129:
2090:
1910:
1629:
1045:
878:
341:
Unchanged drug (up to 70%) and alcoholic metabolite (30%) are excreted in the urine
202:
197:
192:
187:
182:
976:
Neostigmine is administered intravenously. The drug should be administered when a
1665:
786:
Common side effects include nausea, increased saliva, crampy abdominal pain, and
409:
3920:
3758:
3678:
3622:
3516:
3461:
3363:
3128:
3028:
2903:
2858:
2702:
2697:
2692:
2586:
2531:
2516:
2496:
2481:
2250:
2234:
2200:
2190:
2152:
2109:
1984:
1947:
1932:
1557:
1339:
803:
772:
3945:
3941:
3673:
3663:
3658:
3571:
3546:
3506:
3501:
3491:
3476:
3417:
3412:
3223:
3083:
3068:
3038:
3013:
2988:
2943:
2938:
2928:
2898:
2868:
2732:
2722:
2667:
2662:
2633:
2610:
2576:
2541:
2526:
2491:
2466:
2320:
2270:
2260:
2224:
2219:
2167:
1979:
1971:
857:
853:
752:
711:
InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1
645:
448:
162:
437:
3784:
3668:
3617:
3526:
3521:
3511:
3353:
3288:
3283:
3273:
3228:
3198:
3193:
3178:
3163:
3133:
3098:
3088:
2993:
2873:
2863:
2853:
2823:
2818:
2813:
2737:
2712:
2677:
2606:
2581:
2551:
2511:
2461:
2275:
2147:
2142:
2137:
2008:
1995:
1942:
882:
799:
336:
66:
22:
1673:
1637:
1569:
1542:
1523:
1460:
1418:
1351:
1244:
World Health
Organization model list of essential medicines: 21st list 2019
1759:
1723:
1400:
3951:
3653:
3586:
3541:
3471:
3439:
3338:
3318:
3308:
3173:
3093:
3023:
3008:
2893:
2888:
2793:
2727:
2672:
2596:
2546:
2476:
2456:
2056:
2036:
1902:
902:
420:
94:
1252:
429:
30:
3688:
3596:
3561:
3333:
3233:
3203:
3188:
3138:
3033:
2978:
2973:
2968:
2963:
2958:
2953:
2948:
2923:
2878:
2772:
2767:
2687:
2682:
2556:
2162:
1157:
947:
825:, meaning "new", and "-stigmine", in reference to its parent molecule,
395:
1452:
1189:. The American Society of Health-System Pharmacists. 19 September 2019
3213:
3003:
2762:
2757:
2752:
2747:
2561:
2335:
1906:
930:
536:
298:
Slow hydrolysis by acetylcholinesterase and also by plasma esterases
505:
497:
3591:
3313:
3303:
3153:
3048:
2398:
668:
659:
516:
1024:
Neostigmine is made by first reacting 3-dimethylaminophenol with
874:
Neostigmine is often prescribed for underactive urinary bladder.
1602:
488:
246:
2290:
1874:
1484:"Potential Treatment For Snakebites Leads To A Paralyzing Test"
894:
bronchoconstriction. Gastrointestinal symptoms occur earliest.
259:
89:
1699:(3rd ed.). Lippincott's Illustrated Reviews. p. 51.
1695:
Howland RD, Mycek MJ, Harvey RA, Champe PC, Mycek MJ (2008).
2743:
Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide)
1366:"Neostigmine Injection: Indications, Side Effects, Warnings"
561:
3856:
3769:
2789:
2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate
233:
121:
3825:
1385:"Acute intestinal pseudo-obstruction (Ogilvie's syndrome)"
806:
family of medications. It works by blocking the action of
1605:(6th ed.). New York: Macmillan Publishing Co., Inc.
1256:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
1183:"Neostigmine Methylsulfate Monograph for Professionals"
819:
734:
3992:
1784:
1121:. The American Society of Health-System Pharmacists.
308:
Within 10-20 min (injection), with 4 hrs (by mouth)
1505:
Bulfone TC, Samuel SP, Bickler PE, Lewin MR (2018).
3910:
3814:
3797:
3767:
3726:
3709:
3636:
2432:
2351:
2334:
2243:
2176:
2128:
2069:
2017:
1993:
1970:
1961:
1918:
897:For this reason, it is usually given along with an
657:
644:
611:
606:
587:
555:
535:
515:
487:
467:
447:
419:
394:
374:
345:
335:
325:
312:
302:
292:
282:
274:
223:
218:
173:
161:
135:
109:
79:
61:
51:
46:
2353:
841:It is used to improve muscle tone in people with
1072:"Bloxiverz- neostigmine methylsulfate injection"
408:
1564:. Treasure Island (FL): StatPearls Publishing.
1346:. Treasure Island (FL): StatPearls Publishing.
1147:(2009). Stuart MC, Kouimtzi M, Hill SR (eds.).
817:Neostigmine was patented in 1931. It is on the
383:
3698:Many of the other AChE inhibitors listed above
1583:
1581:
1579:
4050:World Health Organization essential medicines
3638:
2302:
1886:
1333:
1331:
1329:
1327:
829:, on which it is based. It is available as a
8:
3977:Muscarinic acetylcholine receptor modulators
2434:
802:is safe for the baby. Neostigmine is in the
98:
21:
3982:Nicotinic acetylcholine receptor modulators
3861:Tooltip Vesicle-associated membrane protein
3774:Tooltip Vesicular acetylcholine transporter
3728:
1113:
921:Acetylcholine is metabolized by the enzyme
206:
3830:Tooltip Synaptosomal-associated protein 25
3811:
3723:
2348:
2309:
2295:
2287:
1967:
1893:
1879:
1871:
1151:. World Health Organization. p. 428.
1111:
1109:
1107:
1105:
1103:
1101:
1099:
1097:
1095:
1093:
598:
575:
456:
57:Bloxiverz, Prostigmin, Vagostigmin, others
38:
29:
1532:
1522:
1408:
1251:
1156:
845:, and also to reverse the effects of non-
476:
1740:The Journal of Pharmacy and Pharmacology
867:of acute colonic pseudo-obstruction, or
3999:
2934:Dimethyl 4-(methylthio)phenyl phosphate
1298:"Competitive Generic Therapy Approvals"
1037:
708:
688:
571:
436:
428:
359:
16:Anti-full body paralysis drug treatment
1228:from the original on 20 December 2016.
1214:. John Wiley & Sons. p. 540.
810:and therefore increases the levels of
589:
20:
3124:Methylfluorophosphonylcholine (MFPCh)
2374:2-(α-Naphthoyl)ethyltrimethylammonium
1246:. Geneva: World Health Organization.
1125:from the original on 21 December 2016
544:
524:
71:
7:
1866:. U.S. National Library of Medicine.
1854:. U.S. National Library of Medicine.
1842:. U.S. National Library of Medicine.
1815:, Aeschliman JA, issued 1933
196:
186:
3921:
2424:N,N-Dimethylaminoethylchloroacetate
1389:Clinics in Colon and Rectal Surgery
1338:Neely GA, Sabir S, Kohli A (2022).
790:. More severe side effects include
504:
496:
399:
1752:10.1111/j.2042-7158.1993.tb05598.x
1046:"Neostigmine Use During Pregnancy"
863:Another indication for use is the
771:. It is given by injection either
14:
2358:Tooltip Choline acetyltransferase
1383:Maloney N, Vargas HD (May 2005).
1312:from the original on 29 June 2023
769:neuromuscular blocking medication
4002:
3418:Fasciculins (green mamba toxins)
2909:Dicyclohexyl phosphorofluoridate
937:molecules before they reach the
629:
623:
4025:Acetylcholinesterase inhibitors
3349:Tetraethyl pyrophosphate (TEPP)
3074:Hexaethyl tetraphosphate (HETP)
2019:acetylcholinesterase inhibitors
1789:Springer Science+Business Media
1710:Porst H, Kny L (May 1985). "".
1208:Fischer J, Ganellin CR (2006).
716:Key:ALWKGYPQUAPLQC-UHFFFAOYSA-N
691:CN(C)C(=O)OC1=CC=CC(=C1)(C)(C)C
2419:N,N-Dimethylaminoethylacrylate
1630:10.1016/j.jclinane.2016.09.013
1618:Journal of Clinical Anesthesia
997:forming the desired compound.
635:
617:
288:Unclear, probably less than 5%
1:
4045:Quaternary ammonium compounds
3972:Receptor/signaling modulators
3744:Hemicholinium-3 (hemicholine)
3643:Tooltip Butyrylcholinesterase
2071:Carbonic anhydrase inhibitors
1211:Analogue-based Drug Discovery
2439:Tooltip Acetylcholinesterase
1666:10.1213/ANE.0000000000003734
1511:Journal of Tropical Medicine
1441:Neurourology and Urodynamics
1304:Food and Drug Administration
860:at the end of an operation.
747:, sold under the brand name
3733:Tooltip Choline transporter
3679:Profenamine (ethopropazine)
2919:Diisopropyl fluorophosphate
2384:4-(1-Naphthylvinyl)pyridine
2369:1-(-Benzoylethyl)pyridinium
1848:"Neostigmine methylsulfate"
1556:Naji A, Gatling JW (2022).
1482:Franklin D (31 July 2013).
978:peripheral nerve stimulator
4066:
3582:Dimethylcarbamoyl fluoride
2389:Acetylseco hemicholinium-3
1272:www.oxforddictionaries.com
798:. It is unclear if use in
607:Chemical and physical data
3964:
1240:World Health Organization
1145:World Health Organization
946:, neostigmine indirectly
821:. The term is from Greek
724:
699:
679:
350:
37:
28:
3452:Methanesulfonyl fluoride
1654:Anesthesia and Analgesia
1558:"Muscarinic Antagonists"
1149:WHO Model Formulary 2008
168:Cholinesterase inhibitor
4035:Dimethylamino compounds
2629:+glycopyrronium bromide
2178:Prostaglandin analogues
1864:Drug Information Portal
1852:Drug Information Portal
1840:Drug Information Portal
933:from breaking down the
865:conservative management
503:as methylsulfate:
435:as methylsulfate:
366:-trimethylbenzenaminium
2379:3-Chloro-4-stillbazole
1860:"Neostigmine bromide"
1401:10.1055/s-2005-870890
1119:"Neostigmine Bromide"
939:postsynaptic membrane
751:, among others, is a
3940:Atracotoxins (e.g.,
3567:Tetrahydrocannabinol
2914:Diisopropylphosphate
2215:Latanoprostene bunod
2130:Beta blocking agents
1963:Parasympathomimetics
1781:Whitacre DM (2007).
1524:10.1155/2018/4320175
956:muscarinic receptors
927:acetylcholinesterase
923:acetylcholinesterase
808:acetylcholinesterase
4040:Ophthalmology drugs
4030:Aromatic carbamates
3926:Tooltip Latrophilin
3628:Trimedoxime bromide
3557:Stercuronium iodide
3374:Tricresyl phosphate
2849:Chlorpyrifos-methyl
1278:on 22 December 2015
967:blood–brain barrier
929:, which blocks the
255:(Prescription only)
242:(Prescription only)
25:
3445:Onchidella binneyi
2787:Organophosphates:
1010:H NMR Spectroscopy
869:Ogilvie's syndrome
831:generic medication
796:allergic reactions
792:low blood pressure
327:Duration of action
3990:
3989:
3960:
3959:
3808:
3793:
3792:
3720:
3705:
3704:
3344:Tetrachlorvinphos
3219:Pirimiphos-methyl
3169:Oxydemeton-methyl
3119:Methyl phenkapton
2345:
2284:
2283:
2065:
2064:
1905:preparations and
1798:978-0-387-73162-9
1494:on 9 August 2014.
1453:10.1002/nau.24839
843:myasthenia gravis
765:urinary retention
757:myasthenia gravis
742:
741:
670:Interactive image
557:CompTox Dashboard
263:
250:
237:
125:
92:
4057:
4007:
4006:
4005:
3998:
3927:
3923:
3862:
3858:
3831:
3827:
3812:
3802:
3775:
3771:
3734:
3730:
3724:
3714:
3644:
3640:
3608:Asoxime chloride
3184:Parathion-methyl
2884:Demeton-S-methyl
2440:
2436:
2359:
2355:
2349:
2339:
2311:
2304:
2297:
2288:
1968:
1920:Sympathomimetics
1895:
1888:
1881:
1872:
1867:
1855:
1843:
1822:
1821:
1820:
1816:
1809:
1803:
1802:
1778:
1772:
1771:
1734:
1728:
1727:
1707:
1701:
1700:
1692:
1686:
1685:
1660:(6): 1434–1439.
1648:
1642:
1641:
1613:
1607:
1606:
1585:
1574:
1573:
1553:
1547:
1546:
1536:
1526:
1502:
1496:
1495:
1490:. Archived from
1479:
1473:
1472:
1438:
1429:
1423:
1422:
1412:
1380:
1374:
1373:
1362:
1356:
1355:
1335:
1322:
1321:
1319:
1317:
1308:. 29 June 2023.
1294:
1288:
1287:
1285:
1283:
1274:. Archived from
1264:
1258:
1257:
1255:
1236:
1230:
1229:
1205:
1199:
1198:
1196:
1194:
1179:
1173:
1172:
1160:
1141:
1135:
1134:
1132:
1130:
1115:
1088:
1087:
1085:
1083:
1068:
1062:
1061:
1059:
1057:
1052:. 3 January 2020
1042:
995:dimethyl sulfate
899:anti-cholinergic
850:muscle relaxants
794:, weakness, and
761:Ogilvie syndrome
738:
737:
730:
672:
652:
637:
631:
625:
619:
602:
591:
580:
579:
565:
563:
548:
528:
508:
500:
480:
460:
440:
432:
412:
402:
401:
387:
317:
261:
258:
248:
245:
235:
232:
210:
200:
190:
123:
120:
102:
91:
88:
75:
42:
33:
26:
24:
4065:
4064:
4060:
4059:
4058:
4056:
4055:
4054:
4015:
4014:
4013:
4003:
4001:
3993:
3991:
3986:
3956:
3925:
3906:
3866:Botulinum toxin
3860:
3835:Botulinum toxin
3829:
3801:
3789:
3773:
3763:
3749:Triethylcholine
3732:
3713:
3701:
3642:
3632:
3552:Rosmarinic acid
3319:Sulfotep (TEDP)
2989:Ethylsarin (GE)
2869:Cyclosarin (GF)
2839:Chlorfenvinphos
2829:Carbophenothion
2809:Azinphos-methyl
2438:
2428:
2394:Acryloylcholine
2357:
2338:
2330:
2315:
2285:
2280:
2239:
2183:
2172:
2124:
2074:
2061:
2013:
1989:
1957:
1914:
1901:Drugs used for
1899:
1858:
1846:
1834:
1831:
1826:
1825:
1818:
1811:
1810:
1806:
1799:
1780:
1779:
1775:
1736:
1735:
1731:
1709:
1708:
1704:
1694:
1693:
1689:
1650:
1649:
1645:
1615:
1614:
1610:
1587:
1586:
1577:
1555:
1554:
1550:
1504:
1503:
1499:
1481:
1480:
1476:
1436:
1431:
1430:
1426:
1382:
1381:
1377:
1364:
1363:
1359:
1337:
1336:
1325:
1315:
1313:
1296:
1295:
1291:
1281:
1279:
1266:
1265:
1261:
1238:
1237:
1233:
1222:
1207:
1206:
1202:
1192:
1190:
1181:
1180:
1176:
1169:
1143:
1142:
1138:
1128:
1126:
1117:
1116:
1091:
1081:
1079:
1070:
1069:
1065:
1055:
1053:
1044:
1043:
1039:
1034:
1019:
1003:
987:
919:
891:
839:
788:slow heart rate
733:
731:
728:(what is this?)
725:
720:
717:
712:
707:
706:
695:
692:
687:
686:
675:
650:
640:
634:
628:
622:
583:
559:
551:
531:
511:
483:
463:
443:
415:
398:
390:
370:
367:
358:
357:
315:
304:Onset of action
284:Bioavailability
276:Pharmacokinetic
270:
214:
138:
131:
112:
105:
17:
12:
11:
5:
4063:
4061:
4053:
4052:
4047:
4042:
4037:
4032:
4027:
4017:
4016:
4012:
4011:
3988:
3987:
3985:
3984:
3979:
3974:
3969:
3965:
3962:
3961:
3958:
3957:
3955:
3954:
3949:
3934:
3933:
3916:
3914:
3908:
3907:
3905:
3904:
3901:γ-bungarotoxin
3897:β-bungarotoxin
3886:
3885:
3851:
3850:
3820:
3818:
3809:
3795:
3794:
3791:
3790:
3788:
3787:
3778:
3776:
3765:
3764:
3762:
3761:
3752:
3751:
3746:
3737:
3735:
3721:
3707:
3706:
3703:
3702:
3700:
3699:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3661:
3656:
3647:
3645:
3634:
3633:
3631:
3630:
3625:
3620:
3615:
3610:
3600:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3549:
3544:
3539:
3534:
3529:
3524:
3519:
3514:
3509:
3504:
3499:
3494:
3489:
3484:
3479:
3474:
3469:
3464:
3455:
3454:
3449:
3437:
3415:
3406:
3401:
3396:
3391:
3386:
3381:
3376:
3371:
3366:
3361:
3356:
3351:
3346:
3341:
3336:
3331:
3326:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3246:
3241:
3236:
3231:
3226:
3221:
3216:
3211:
3206:
3201:
3196:
3191:
3186:
3181:
3176:
3171:
3166:
3161:
3159:Novichok agent
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3091:
3086:
3081:
3079:Isofluorophate
3076:
3071:
3066:
3061:
3056:
3051:
3046:
3041:
3036:
3031:
3026:
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2834:Chlorethoxyfos
2831:
2826:
2821:
2816:
2811:
2806:
2804:Azinphos-ethyl
2801:
2796:
2791:
2781:
2780:
2775:
2770:
2765:
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2720:
2715:
2710:
2705:
2700:
2695:
2690:
2685:
2680:
2675:
2670:
2665:
2656:
2651:
2646:
2644:Pyridostigmine
2641:
2636:
2631:
2623:
2618:
2613:
2604:
2599:
2594:
2589:
2584:
2579:
2574:
2569:
2564:
2559:
2554:
2549:
2544:
2539:
2534:
2529:
2524:
2519:
2514:
2509:
2504:
2499:
2494:
2489:
2484:
2479:
2474:
2469:
2464:
2459:
2443:
2441:
2430:
2429:
2427:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2381:
2376:
2371:
2362:
2360:
2346:
2332:
2331:
2316:
2314:
2313:
2306:
2299:
2291:
2282:
2281:
2279:
2278:
2273:
2268:
2258:
2253:
2247:
2245:
2241:
2240:
2238:
2237:
2232:
2222:
2217:
2212:
2198:
2187:
2185:
2181:
2174:
2173:
2171:
2170:
2165:
2160:
2155:
2150:
2145:
2140:
2134:
2132:
2126:
2125:
2123:
2122:
2117:
2107:
2102:
2088:
2082:
2080:
2067:
2066:
2063:
2062:
2060:
2059:
2054:
2048:
2043:
2034:
2029:
2023:
2021:
2015:
2014:
2012:
2011:
2006:
2000:
1998:
1991:
1990:
1988:
1987:
1982:
1976:
1974:
1965:
1959:
1958:
1956:
1955:
1950:
1945:
1940:
1930:
1924:
1922:
1916:
1915:
1900:
1898:
1897:
1890:
1883:
1875:
1869:
1868:
1856:
1844:
1830:
1829:External links
1827:
1824:
1823:
1804:
1797:
1791:. p. 57.
1773:
1746:(6): 559–562.
1729:
1718:(5): 325–328.
1702:
1687:
1643:
1608:
1575:
1548:
1497:
1474:
1447:(1): 127–139.
1424:
1375:
1357:
1323:
1289:
1259:
1231:
1220:
1200:
1174:
1167:
1136:
1089:
1078:. 3 March 2021
1063:
1036:
1035:
1033:
1030:
1018:
1015:
1008:Neostigmine's
1002:
999:
986:
983:
969:and enter the
918:
915:
907:glycopyrrolate
890:
887:
838:
835:
781:under the skin
755:used to treat
740:
739:
722:
721:
719:
718:
715:
713:
710:
702:
701:
700:
697:
696:
694:
693:
690:
682:
681:
680:
677:
676:
674:
673:
665:
663:
655:
654:
648:
642:
641:
638:
632:
626:
620:
615:
609:
608:
604:
603:
593:
585:
584:
582:
581:
568:
566:
553:
552:
550:
549:
541:
539:
533:
532:
530:
529:
521:
519:
513:
512:
510:
509:
501:
493:
491:
485:
484:
482:
481:
473:
471:
465:
464:
462:
461:
453:
451:
445:
444:
442:
441:
433:
425:
423:
417:
416:
414:
413:
405:
403:
392:
391:
389:
388:
380:
378:
372:
371:
369:
368:
361:
353:
352:
351:
348:
347:
343:
342:
339:
333:
332:
329:
323:
322:
319:
310:
309:
306:
300:
299:
296:
290:
289:
286:
280:
279:
272:
271:
269:
268:
256:
243:
229:
227:
221:
220:
216:
215:
213:
212:
179:
177:
171:
170:
165:
159:
158:
141:
139:administration
133:
132:
130:
129:
127:
117:
115:
107:
106:
104:
103:
85:
83:
77:
76:
69:
59:
58:
55:
49:
48:
44:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
4062:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4022:
4020:
4010:
4000:
3996:
3983:
3980:
3978:
3975:
3973:
3970:
3967:
3966:
3963:
3953:
3950:
3947:
3943:
3939:
3936:
3935:
3932:
3929:
3924:
3918:
3917:
3915:
3913:
3909:
3902:
3898:
3894:
3893:Bungarotoxins
3891:
3888:
3887:
3883:
3879:
3875:
3871:
3867:
3864:
3863:inactivators:
3859:
3853:
3852:
3848:
3844:
3840:
3836:
3833:
3832:inactivators:
3828:
3822:
3821:
3819:
3817:
3813:
3810:
3806:
3800:
3796:
3786:
3783:
3780:
3779:
3777:
3772:
3766:
3760:
3757:
3754:
3753:
3750:
3747:
3745:
3742:
3739:
3738:
3736:
3731:
3725:
3722:
3718:
3712:
3708:
3697:
3695:
3694:ZINC-12613047
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3649:
3648:
3646:
3641:
3635:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3605:
3602:
3601:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3537:Lactucopicrin
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3457:
3456:
3453:
3450:
3447:
3446:
3441:
3438:
3435:
3431:
3427:
3423:
3419:
3416:
3414:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3369:Trichloronate
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3144:Monocrotophos
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3109:Methamidophos
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2984:Echothiophate
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2790:
2786:
2785:Irreversible:
2783:
2782:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2706:
2704:
2701:
2699:
2696:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2660:
2657:
2655:
2652:
2650:
2649:Quilostigmine
2647:
2645:
2642:
2640:
2639:Physostigmine
2637:
2635:
2632:
2630:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:; Stigmines:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2507:Chloropropham
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2463:
2460:
2458:
2454:
2451:
2449:
2445:
2444:
2442:
2437:
2431:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2377:
2375:
2372:
2370:
2367:
2364:
2363:
2361:
2356:
2350:
2347:
2343:
2337:
2333:
2329:
2326:
2322:
2319:
2318:Acetylcholine
2312:
2307:
2305:
2300:
2298:
2293:
2292:
2289:
2277:
2274:
2272:
2269:
2266:
2262:
2259:
2257:
2254:
2252:
2249:
2248:
2246:
2242:
2236:
2233:
2230:
2226:
2223:
2221:
2218:
2216:
2213:
2210:
2206:
2202:
2199:
2196:
2192:
2189:
2188:
2186:
2179:
2175:
2169:
2166:
2164:
2161:
2159:
2156:
2154:
2151:
2149:
2146:
2144:
2141:
2139:
2136:
2135:
2133:
2131:
2127:
2121:
2120:Methazolamide
2118:
2115:
2111:
2108:
2106:
2105:Diclofenamide
2103:
2100:
2096:
2092:
2089:
2087:
2086:Acetazolamide
2084:
2083:
2081:
2078:
2072:
2068:
2058:
2055:
2052:
2051:Physostigmine
2049:
2047:
2044:
2042:
2038:
2035:
2033:
2030:
2028:
2025:
2024:
2022:
2020:
2016:
2010:
2007:
2005:
2004:Acetylcholine
2002:
2001:
1999:
1997:
1992:
1986:
1983:
1981:
1978:
1977:
1975:
1973:
1969:
1966:
1964:
1960:
1954:
1951:
1949:
1946:
1944:
1941:
1938:
1934:
1931:
1929:
1928:Apraclonidine
1926:
1925:
1923:
1921:
1917:
1912:
1908:
1904:
1896:
1891:
1889:
1884:
1882:
1877:
1876:
1873:
1865:
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1836:"Neostigmine"
1833:
1832:
1828:
1814:
1808:
1805:
1800:
1794:
1790:
1786:
1785:
1777:
1774:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1741:
1733:
1730:
1725:
1721:
1717:
1714:(in German).
1713:
1712:Die Pharmazie
1706:
1703:
1698:
1691:
1688:
1683:
1679:
1675:
1671:
1667:
1663:
1659:
1655:
1647:
1644:
1639:
1635:
1631:
1627:
1623:
1619:
1612:
1609:
1604:
1603:
1598:
1594:
1590:
1584:
1582:
1580:
1576:
1571:
1567:
1563:
1559:
1552:
1549:
1544:
1540:
1535:
1530:
1525:
1520:
1516:
1512:
1508:
1501:
1498:
1493:
1489:
1485:
1478:
1475:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1435:
1428:
1425:
1420:
1416:
1411:
1406:
1402:
1398:
1395:(2): 96–101.
1394:
1390:
1386:
1379:
1376:
1371:
1367:
1361:
1358:
1353:
1349:
1345:
1341:
1340:"Neostigmine"
1334:
1332:
1330:
1328:
1324:
1311:
1307:
1305:
1299:
1293:
1290:
1277:
1273:
1269:
1263:
1260:
1254:
1249:
1245:
1241:
1235:
1232:
1227:
1223:
1221:9783527607495
1217:
1213:
1212:
1204:
1201:
1188:
1184:
1178:
1175:
1170:
1168:9789241547659
1164:
1159:
1154:
1150:
1146:
1140:
1137:
1124:
1120:
1114:
1112:
1110:
1108:
1106:
1104:
1102:
1100:
1098:
1096:
1094:
1090:
1077:
1073:
1067:
1064:
1051:
1047:
1041:
1038:
1031:
1029:
1027:
1022:
1016:
1014:
1011:
1006:
1001:Spectral data
1000:
998:
996:
992:
984:
982:
979:
974:
972:
968:
964:
963:physostigmine
959:
957:
953:
949:
945:
944:acetylcholine
940:
936:
935:acetylcholine
932:
928:
924:
916:
914:
910:
908:
904:
901:drug such as
900:
895:
888:
886:
884:
880:
875:
872:
870:
866:
861:
859:
855:
851:
848:
844:
836:
834:
832:
828:
827:physostigmine
824:
820:
815:
813:
812:acetylcholine
809:
805:
801:
797:
793:
789:
784:
782:
778:
774:
770:
766:
762:
758:
754:
750:
746:
736:
729:
723:
714:
709:
705:
698:
689:
685:
678:
671:
667:
666:
664:
661:
656:
649:
647:
643:
616:
614:
610:
605:
601:
597:
594:
592:
590:ECHA InfoCard
586:
578:
574:
573:DTXSID1023360
570:
569:
567:
558:
554:
547:
543:
542:
540:
538:
534:
527:
523:
522:
520:
518:
514:
507:
502:
499:
495:
494:
492:
490:
486:
479:
475:
474:
472:
470:
466:
459:
455:
454:
452:
450:
446:
439:
434:
431:
427:
426:
424:
422:
418:
411:
407:
406:
404:
397:
393:
386:
382:
381:
379:
377:
373:
365:
360:
356:
349:
344:
340:
338:
334:
330:
328:
324:
321:50–90 minutes
320:
318:
311:
307:
305:
301:
297:
295:
291:
287:
285:
281:
277:
273:
267:
257:
254:
244:
241:
231:
230:
228:
226:
222:
217:
209:
204:
199:
194:
189:
184:
181:
180:
178:
176:
172:
169:
166:
164:
160:
157:
153:
149:
145:
144:Intramuscular
142:
140:
134:
128:
119:
118:
116:
114:
108:
101:
96:
87:
86:
84:
82:
78:
74:
70:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
3937:
3931:α-Latrotoxin
3919:
3889:
3854:
3823:
3781:
3755:
3740:
3684:Rivastigmine
3650:
3604:Reactivators
3577:Ungiminorine
3532:Kobophenol A
3497:Coronaridine
3487:Bulbocapnine
3482:Arisugacin A
3458:
3443:
3329:Tebupirimfos
3209:Phosphamidon
3114:Methidathion
3019:Fenitrothion
2844:Chlorpyrifos
2784:
2659:Terestigmine
2654:Rivastigmine
2625:
2616:Eptastigmine
2567:Phenmedipham
2537:Formparanate
2522:Ethiofencarb
2455:Carbamates:
2452:
2446:
2365:
2265:+latanoprost
2256:Guanethidine
2244:Other agents
2158:Metipranolol
2099:+brimonidine
2091:Brinzolamide
2077:sulfonamides
2045:
2041:Fluostigmine
1863:
1851:
1839:
1807:
1783:
1776:
1743:
1739:
1732:
1715:
1711:
1705:
1697:Pharmacology
1696:
1690:
1657:
1653:
1646:
1621:
1617:
1611:
1601:
1561:
1551:
1514:
1510:
1500:
1492:the original
1487:
1477:
1444:
1440:
1427:
1392:
1388:
1378:
1369:
1360:
1343:
1314:. Retrieved
1301:
1292:
1280:. Retrieved
1276:the original
1271:
1262:
1253:10665/325771
1243:
1234:
1210:
1203:
1191:. Retrieved
1186:
1177:
1148:
1139:
1127:. Retrieved
1080:. Retrieved
1075:
1066:
1054:. Retrieved
1049:
1040:
1025:
1023:
1020:
1007:
1004:
990:
988:
975:
960:
920:
917:Pharmacology
911:
896:
892:
889:Side effects
879:envenomation
876:
873:
862:
847:depolarizing
840:
837:Medical uses
822:
816:
785:
748:
744:
743:
732:
726:
438:DBSALT000128
363:
314:Elimination
225:Legal status
219:Legal status
152:subcutaneous
81:License data
18:
3782:Inhibitors:
3759:Coluracetam
3741:Inhibitors:
3711:Transporter
3651:Inhibitors:
3623:Pralidoxime
3517:Cyclanoline
3467:α-Viniferin
3364:Trichlorfon
3129:Metrifonate
3044:Fosthiazate
3029:Fluorotabun
2904:Dicrotophos
2859:Crotylsarin
2703:Huperzine A
2698:Galantamine
2693:Edrophonium
2626:Neostigmine
2621:Ganstigmine
2587:Propamocarb
2532:Formetanate
2517:Ethienocarb
2497:Carbosulfan
2487:Carbetamide
2482:Carbendazim
2453:Reversible:
2366:Inhibitors:
2251:Dapiprazole
2235:Unoprostone
2205:+netarsudil
2201:Latanoprost
2191:Bimatoprost
2153:Levobunolol
2110:Dorzolamide
2046:Neostigmine
2032:Ecothiopate
1994:muscarinic/
1985:Pilocarpine
1953:Epinephrine
1948:Dipivefrine
1933:Brimonidine
1597:Gilman Sr A
1562:StatPearls
1517:: 4320175.
1344:StatPearls
1282:17 December
1158:10665/44053
804:cholinergic
773:into a vein
745:Neostigmine
653: g·mol
596:100.305.602
546:ChEMBL54126
346:Identifiers
331:up to 4 hrs
148:intravenous
100:Neostigmine
53:Trade names
23:Neostigmine
4019:Categories
3946:versutoxin
3942:robustoxin
3816:Inhibitors
3805:modulators
3756:Enhancers:
3717:modulators
3674:Ladostigil
3664:Conodurine
3659:Affinisine
3572:Ungeremine
3547:Phosacetim
3507:Corynoline
3502:Corydaline
3492:Conodurine
3477:Affinisine
3413:Demecarium
3411:; Others:
3324:Tabun (GA)
3314:Soman (GD)
3304:Sarin (GB)
3224:Profenofos
3084:Isoxathion
3069:Guanitoxin
3039:Formothion
3014:Fenamiphos
2944:Disulfoton
2939:Dioxathion
2929:Dimethoate
2899:Dichlorvos
2733:Ladostigil
2723:Ipidacrine
2668:Ambenonium
2663:Acotiamide
2661:; Others:
2634:Phenserine
2611:Distigmine
2602:Thiodicarb
2577:Pirimicarb
2542:Methiocarb
2527:Fenobucarb
2502:Chlorbufam
2492:Carbofuran
2467:Bendiocarb
2448:Inhibitors
2342:modulators
2328:modulators
2321:metabolism
2271:Omidenepag
2261:Netarsudil
2225:Travoprost
2220:Tafluprost
2168:Mepindolol
2027:Demecarium
1980:Aceclidine
1972:muscarinic
1813:US 1905990
1593:Goodman LS
1193:20 January
1129:8 December
1056:21 January
1032:References
948:stimulates
858:vecuronium
854:rocuronium
753:medication
658:3D model (
646:Molar mass
526:CHEBI:7514
478:3982TWQ96G
449:ChemSpider
376:CAS Number
355:IUPAC name
294:Metabolism
163:Drug class
3928:agonists:
3912:Enhancers
3785:Vesamicol
3669:Cymserine
3618:Obidoxime
3613:Methoxime
3527:Harmaline
3522:Cymserine
3512:Crimidine
3459:Unsorted:
3354:Triazofos
3294:Ro 3-0433
3289:Ro 3-0422
3284:Ro 3-0419
3279:Ro 3-0417
3274:Ro 3-0412
3269:Ro 3-0411
3264:Ro 3-0397
3259:Ro 3-0352
3254:Ro 3-0351
3249:Ro 3-0347
3244:Ro 3-0346
3239:Ro 3-0340
3229:Prothoate
3199:Phosfolan
3194:Phosalone
3179:Parathion
3164:Omethoate
3134:Mevinphos
3099:Malathion
3089:Leptophos
2994:Endothion
2874:Demephion
2864:Cyanophos
2854:Coumaphos
2824:Cadusafos
2819:Bensulide
2814:BAY-29952
2778:Zanapezil
2738:Minaprine
2718:Huprine Y
2713:Huprine X
2708:Huprine W
2678:Donepezil
2607:Thiofanox
2582:Promecarb
2572:Pinmicarb
2552:Metolcarb
2512:Dimetilan
2472:Bufencarb
2462:Aminocarb
2414:CM-54,903
2325:transport
2276:Ripasudil
2148:Carteolol
2143:Betaxolol
2138:Befunolol
2009:Carbachol
1996:nicotinic
1943:Clonidine
1624:: 51–53.
1589:Gilman AG
1469:244530010
1370:Drugs.com
1187:Drugs.com
1050:Drugs.com
985:Chemistry
952:nicotinic
883:snakebite
800:pregnancy
749:Bloxiverz
337:Excretion
316:half-life
137:Routes of
111:Pregnancy
73:Monograph
67:Drugs.com
4009:Medicine
3968:See also
3952:Crotoxin
3654:Affinine
3587:BW284C51
3542:Lycorine
3472:Affinine
3462:α-Pinene
3440:Onchidal
3359:Tribufos
3339:Terbufos
3309:Schradan
3174:Paraoxon
3094:Malaoxon
3024:Fenthion
3009:Ethoprop
2894:Diazinon
2889:Dialifor
2794:Acephate
2728:Itopride
2673:Caffeine
2597:Propoxur
2547:Methomyl
2477:Carbaryl
2457:Aldicarb
2229:+timolol
2209:+timolol
2195:+timolol
2114:+timolol
2095:+timolol
2057:Paraoxon
2037:Stigmine
1937:+timolol
1903:glaucoma
1768:38613106
1682:52142441
1674:30169405
1638:28183573
1599:(1980).
1570:32491473
1543:30154870
1461:34816481
1419:20011348
1352:29261883
1310:Archived
1242:(2019).
1226:Archived
1123:Archived
1076:DailyMed
903:atropine
881:through
852:such as
735:(verify)
421:DrugBank
362:3-{oxy}-
203:QA03AB93
175:ATC code
156:by mouth
126: B2
113:category
95:DailyMed
3938:Others:
3890:Others:
3826:SNAP-25
3799:Release
3689:Tacrine
3597:3152 CT
3562:Taspine
3334:Temefos
3234:R-16661
3204:Phosmet
3189:Phorate
3139:Mipafox
3104:Mazidox
3034:Fonofos
2979:EA-4352
2974:EA-3148
2969:EA-2613
2964:EA-2192
2959:EA-2098
2954:EA-2054
2949:EA-2012
2924:Dimefox
2879:Demeton
2773:Tacrine
2768:TL-1238
2688:EA-4056
2683:EA-3990
2592:Propham
2557:Miotine
2163:Timolol
1760:8103105
1724:4034636
1534:6091453
1410:2780141
1316:29 June
1082:15 July
1017:History
961:Unlike
651:223.296
613:Formula
430:DB01400
396:PubChem
385:59-99-4
205: (
195: (
193:S01EB06
191:)
185: (
183:N07AA01
97::
3995:Portal
3299:Ronnel
3214:Phoxim
3004:Ethion
2799:Armine
2763:TL-599
2758:T-1194
2753:T-1152
2748:T-1123
2562:Oxamyl
2336:Enzyme
1907:miosis
1819:
1795:
1766:
1758:
1722:
1680:
1672:
1636:
1568:
1541:
1531:
1467:
1459:
1417:
1407:
1350:
1218:
1165:
931:enzyme
777:muscle
763:, and
684:SMILES
537:ChEMBL
506:D00998
498:D08261
266:℞-only
264:
251:
238:
93:
3770:VAChT
3592:TMTFA
3154:Naled
3059:GT-45
3049:GD-42
2399:AF64A
1764:S2CID
1678:S2CID
1465:S2CID
1437:(PDF)
1306:(FDA)
1302:U.S.
950:both
779:, or
704:InChI
660:JSmol
517:ChEBI
364:N,N,N
3922:LPHN
3857:VAMP
3639:BChE
3149:MSPI
2435:AChE
2409:BETA
2404:B115
2354:ChAT
2323:and
1911:S01E
1793:ISBN
1756:PMID
1720:PMID
1670:PMID
1634:PMID
1566:PMID
1539:PMID
1515:2018
1457:PMID
1415:PMID
1348:PMID
1318:2023
1284:2015
1216:ISBN
1195:2020
1163:ISBN
1131:2016
1084:2022
1058:2020
954:and
856:and
823:neos
489:KEGG
469:UNII
458:4301
410:4456
278:data
63:AHFS
3729:CHT
2999:EPN
1748:doi
1662:doi
1658:127
1626:doi
1529:PMC
1519:doi
1488:NPR
1449:doi
1405:PMC
1397:doi
1248:hdl
1153:hdl
973:.
971:CNS
905:or
562:EPA
400:CID
253:POM
208:WHO
198:WHO
188:WHO
4021::
3944:,
3899:,
3880:,
3876:,
3872:,
3845:,
3841:,
3606::
3432:,
3428:,
3424:,
3409:VX
3404:VR
3399:VS
3394:VP
3389:VM
3384:VG
3379:VE
3064:GV
3054:GH
2207:,
2182:2α
2180:(F
2097:,
1862:.
1850:.
1838:.
1787:.
1762:.
1754:.
1744:45
1742:.
1716:40
1676:.
1668:.
1656:.
1632:.
1622:36
1620:.
1595:,
1591:,
1578:^
1560:.
1537:.
1527:.
1513:.
1509:.
1486:.
1463:.
1455:.
1445:41
1443:.
1439:.
1413:.
1403:.
1393:18
1391:.
1387:.
1368:.
1342:.
1326:^
1300:.
1270:.
1224:.
1185:.
1161:.
1092:^
1074:.
1048:.
958:.
833:.
814:.
775:,
759:,
627:19
621:12
260:US
247:UK
240:S4
234:AU
201:)
154:,
150:,
146:,
122:AU
90:US
3997::
3948:)
3903:)
3895:(
3884:)
3882:G
3878:F
3874:D
3870:B
3868:(
3849:)
3847:E
3843:C
3839:A
3837:(
3807:)
3803:(
3719:)
3715:(
3448:)
3442:(
3436:)
3434:4
3430:3
3426:2
3422:1
3420:(
2450::
2344:)
2340:(
2310:e
2303:t
2296:v
2267:)
2263:(
2231:)
2227:(
2211:)
2203:(
2197:)
2193:(
2184:)
2116:)
2112:(
2101:)
2093:(
2079:)
2075:(
2073:/
2053:)
2039:(
1939:)
1935:(
1913:)
1909:(
1894:e
1887:t
1880:v
1801:.
1770:.
1750::
1726:.
1684:.
1664::
1640:.
1628::
1572:.
1545:.
1521::
1471:.
1451::
1421:.
1399::
1372:.
1354:.
1320:.
1286:.
1250::
1197:.
1171:.
1155::
1133:.
1086:.
1060:.
1026:N
991:N
662:)
639:2
636:O
633:2
630:N
624:H
618:C
564:)
560:(
262::
249::
236::
211:)
124::
65:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
