809:(NPCs). This was observed in mice lacking Ngn2 and mash-1 (another proneural bHLH transcription factor), which have more glia in the cortex and decreased capacity to generate neurons. Olig2 expression in what will become NPCs precedes Ngn2 and promotes its expression. During the switch from neural progenitor fate to glial fate, Ngn2 is downregulated and
884:(Gsk3). Phosphorylation of Ngn2 enables interaction with LIM-homeodomain proteins, leading to ventral neural fate and motor neuron specification. The importance of this phosphorylation was determined by using mice that express a mutated form of Ngn2 protein which has the serines from the previously mentioned phosphorylation sites mutated into
917:
Ngn3 is a crucial component in pancreatic development and plays a supporting role in intestinal as well as neuronal cell development. Studies have demonstrated that knockout of Ngn3 in mice leads to death shortly after birth possibly due to after effects of severe diabetes. Further studies are taking
888:, which cannot be phosphorylated. These mutant mice have a decreased number of motor neurons and an increased number of V2 interneurons, suggesting that phosphorylation is necessary for driving expression of genes related to motor neuron fate but not V2 interneuron fate and non-specified neural fate.
963:
and
Serrate, activation ligands for the Notch pathway, activates the Notch surface molecule. This allows the Notch intracellular domain to activate RBK-Jκ to translocate into the nucleus. This complex then activates hairy and enhancer of split (HES)-type proteins, which are inhibitors of Ngn3. The
925:
Neurogenin 3 (NGN3) is expressed by 2-10% of acinar and duct cells in the histologically normal adult human pancreas. NGN3+ cells isolated from cultured exocrine tissue by coexpressed cell surface glycoprotein CD133 have a transcriptome consistent with exocrine dedifferentiation, a phenotype that
926:
resembles endocrine progenitor cells during development, and a capacity for endocrine differentiation in vitro. Human and rodent exocrine cells have been reprogrammed into cells with an islet cell-like phenotype following direct expression of NGN3 or manipulation that leads to its expression.
792:
Neurogenin 2 (Ngn2) is a bHLH transcription factor involved in both neurogenesis and neural specification. This protein binds to enhancer-box regulatory elements on the promoters of many genes related to neurogenesis and neural specification. For sufficient DNA binding, Ngn2 must form a
869:(LIM-HD) transcription complex. When an enhancer box of a promoter that has been bound by the heterodimerized Ngn2/E-protein complex, the LIM-HD transcription complex is able to bind to drive expression of genes related to motor neuron fate, but only if Ngn2 has been properly
477:
involved in specifying neuronal differentiation. The family consisting of
Neurogenin-1, Neurogenin-2, and Neurogenin-3, plays a fundamental role in specifying neural precursor cells and regulating the differentiation of neurons during embryonic development. It is one of many
909:
cells. Although its key function is in the pancreas, intestinal cells and neural cells express Ngn3 as well. Several studies have highlighted the importance of Ngn3 for differentiation of endocrine cells. In mice, Ngn3 is present in cells as the pancreas begins to bud and
768:
formation through the inhibition of neuronal differentiation. In addition to the Notch pathway activating the transcriptional factors involved in the promotion of gliogenesis, it is possible that these same factors are involved in the inhibition of other fates.
518:, including the determination of neural progenitor identity, cell cycle exit, and the acquisition of neuronal characteristics. Notably, Neurogenins influence the specification of different neuronal subtypes, contributing to the diverse array of neurons within the
731:
differentiation. In the absence of Ngn1, the CBP/p300/Smad1 transcriptional co-activator complex is recruited to and binds to activated STAT1/3, which in turn causes the expression of GFAP, causing glial differentiation. In the presence of Ngn1, inhibition of
989:(NeuroD1) like most of its other family members through the enhancer boxes present in its structure. Being that NeuroD1 is expressed along with Ngn3 in differentiating cells, it is considered one of the transcription factors downstream targets.
2633:
553:, such as proneural factors and Notch signaling, further refines the neurogenic cascades. Their spatiotemporal expression patterns and cross-regulation contribute to the exquisite precision required for proper neural development.
1013:
Another transcription factor that may be a downstream target of Ngn3 is Nkx2.2 because it is often coexpressed with it. Studies have shown that disrupting Nkx2.2 expression results in problems with α and β cell differentiation.
777:
In the absence of Ngn1, the LIF pathway is able to activate STAT1/3, which allows for the promotion of GFAP transcription via the STAT binding site. The promotion of GFAP transcription induced glial differentiation.
934:
The development of the pancreas is broken up into three phases, primary phase, secondary phase, and tertiary phase. Ngn3 is active in the primary and secondary phase. In the primary phase Ngn3 assists in
2626:
756:, causes the inhibition of proneural bHLH genes, such as Ngn1, which allows for the CBP/p300/Smad1 to interact with STAT1/3 and induce gliogenesis. Along with the embryonic rat, it was also seen in
964:
cells that allow the Notch/RBK-Jκ complex to enter are the ones that will not be differentiated into pancreatic cells because Ngn3 is suppressed. It is important to mention that Ngn3 has three
3555:
8045:
2619:
4054:
692:, Ngn1 is associated with dorsal patterning and cell fate specification, with the patterning molecules and proneural proteins establishing the spatial domains of both proneural and
849:
When an enhancer box of a promoter that has been bound by the Ngn-2/enhancer protein complex is also bound by a dimer of the adaptor nuclear LIM interactor (NLI) bound to two
744:
In cases of low levels of Ngn1, BMPs promote glial differentiation. Since Ngn1 is the limiting factor, CBP/p300/Smad1 is able to interact with STAT1/3 and induce gliogenesis.
6261:
4939:
3961:
3956:
3951:
3600:
3585:
3271:
347:
206:
65:
565:
and neurological regeneration. Aberrations in the expression or regulation of
Neurogenins have been linked to conditions such as autism spectrum disorders and
4094:
7889:
7873:
2692:
3946:
3731:
3724:
3719:
3707:
3702:
3697:
3692:
3687:
3615:
841:
Heterodimerized Ngn2/enhancer protein complex can bind to enhancer boxes to promote transcription of genes related to a non-specified neuronal fate.
7611:
817:
in neural progenitors while allowing the expression of Ngn2. The ability of Olig2 to induce expression of Ngn2 is reduced when Nkx2.2 is expressed.
805:
Ngn2 is a transcription factor that both increases expression of proneural genes and drives neural fate by inhibiting expression of glial genes in
4410:
3469:
8075:
1642:
8070:
8065:
569:. Ongoing research continues to explore the therapeutic potential of manipulating Neurogenin activity for neural repair and regeneration.
7374:
3266:
2838:
371:
230:
89:
1035:
Kageyama R, Ishibashi M, Takebayashi K, Tomita K (December 1997). "bHLH transcription factors and mammalian neuronal differentiation".
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6542:
4629:
4087:
4082:
4010:
4000:
2877:
2867:
2702:
1128:
866:
1549:
4005:
3919:
359:
218:
77:
6941:
4217:
4207:
2808:
2687:
713:
352:
211:
70:
4572:
4212:
3907:
902:
Neurogenin 3 (Ngn3) is another member of the bHLH family of transcription factors. Ngn3 functions in the differentiation of
514:
by activating specific downstream genes associated with neuronal differentiation. Their involvement spans various stages of
2327:"Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice"
7854:
7849:
7000:
3912:
549:
The activity of
Neurogenins is intricately regulated by molecular pathways and environmental cues. Interaction with other
736:
occurs through Ngn1 binding to the CBP/p300/Smad1 transcriptional co-activator complex, recruiting it away from STAT1/3.
7949:
6285:
4435:
3988:
3978:
562:
6454:
6449:
6000:
4077:
3995:
3983:
3059:
643:
727:
Along with supporting neuronal differentiation, when expressed in embryonic neural tissue, Ngn1 also acts to inhibit
2229:"Local in vivo GSK3β knockdown promotes pancreatic β cell and acinar cell regeneration in 90% pancreatectomized rat"
685:
CBP/p300/Smad1 to Ngn1, and being recruited toward the neuronal promoters, causing neuronal differentiation. In the
4190:
3188:
948:
705:
670:
7606:
4487:
4472:
4455:
4450:
4445:
4440:
4351:
4326:
4202:
4114:
4104:
3261:
2734:
674:
566:
523:
7348:
6983:
6499:
6072:
5911:
4846:
4841:
4826:
4301:
4276:
4158:
4109:
3902:
3293:
2759:
716:
592:
490:. Other positive regulators of neuronal differentiation also expressed during early neural development include
1244:"HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade"
7713:
5754:
5071:
4185:
4173:
1490:
Rowitch DH, Kriegstein AR (November 2010). "Developmental genetics of vertebrate glial-cell specification".
753:
623:
7844:
5891:
5886:
4281:
4178:
3973:
3934:
2997:
2646:
1146:"Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia"
765:
519:
364:
223:
813:, which inhibits proneural genes, is upregulated. Glial fate switch was reduced by inhibiting Nkx2.2 and
82:
7836:
7396:
4195:
4131:
4126:
3939:
3015:
2013:"Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate"
474:
417:
2180:"Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas"
7417:
7409:
5247:
4729:
4254:
4249:
4244:
3924:
3807:
2642:
2515:
2083:
2024:
1499:
1446:
947:. Differentiation is marked as complete after the secondary phase. Ngn3 allows for the commitment of
639:
588:
550:
276:
135:
2611:
1563:
Gammill LS, Bronner-Fraser M (October 2003). "Neural crest specification: migrating into genomics".
1001:(Pax4), which plays a major role in β cell and δ cell differentiation. Ngn3 works hand-in-hand with
7731:
7435:
7131:
5334:
4539:
4121:
4099:
4072:
4034:
3968:
2278:"Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats"
2276:
Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, et al. (August 2010).
655:
599:
596:
538:
7269:
2549:
2394:
2386:
2160:
1993:
1747:
1689:
1588:
1523:
1472:
1340:
Christensen EL, Beasley A, Radchuk J, Mielko ZE, Preston E, Stuckett S, et al. (June 2020).
561:
Neurogenins holds significant implications for clinical research, particularly in the context of
2414:"Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway"
2011:
Gomez DL, O'Driscoll M, Sheets TP, Hruban RH, Oberholzer J, McGarrigle JJ, et al. (2015).
1346:/neurogenin Activates Transcription of Multiple Terminal Selector Transcription Factors in the
6851:
6842:
6479:
5427:
4168:
4163:
2598:
2541:
2484:
2435:
2375:
2356:
2307:
2258:
2209:
2152:
2111:
2052:
1985:
1944:
1898:
1850:
1796:
1739:
1681:
1638:
1634:
1580:
1515:
1464:
1379:
1322:
1273:
1224:
1175:
1124:
1101:
1052:
939:
differentiation and in the secondary phase another wave of Ngn3 assists in differentiation of
794:
615:
6662:
6657:
6652:
6647:
6642:
2325:
Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, et al. (January 2014).
2178:
Van de
Casteele M, Leuckx G, Baeyens L, Cai Y, Yuchi Y, Coppens V, et al. (March 2013).
5734:
5378:
5360:
3929:
3876:
3650:
2588:
2580:
2531:
2523:
2474:
2466:
2425:
2367:
2346:
2338:
2297:
2289:
2248:
2240:
2199:
2191:
2142:
2101:
2091:
2042:
2032:
1975:
1934:
1888:
1880:
1840:
1786:
1778:
1729:
1671:
1626:
1572:
1507:
1454:
1369:
1361:
1312:
1304:
1263:
1255:
1214:
1206:
1165:
1157:
1091:
1083:
1044:
806:
662:
to bind to its own enhancer boxes, inducing the genes involved in neuronal differentiation.
421:
412:
271:
130:
6822:
6817:
6767:
6757:
6737:
6722:
6702:
6627:
6607:
5749:
5744:
2453:
Lemper M, Leuckx G, Heremans Y, German MS, Heimberg H, Bouwens L, et al. (July 2015).
2070:
Swales N, Martens GA, Bonné S, Heremans Y, Borup R, Van de
Casteele M, et al. (2012).
658:
for neuronal genes. Binding of Ngn1, to the enhancer box, induces the transcription factor
7519:
6742:
6612:
5978:
5936:
5931:
5926:
5864:
5776:
5698:
5486:
5437:
5432:
3479:
1923:"Neurogenin 3 is a key transcription factor for differentiation of the endocrine pancreas"
870:
635:
507:
441:
300:
159:
2131:"Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas"
677:
CBP, p300, and Smad1. In the presence of Ngn1, BMPs promote neuronal differentiation in
280:
139:
2519:
2087:
2028:
1541:
1503:
1450:
7616:
5896:
5879:
4022:
3677:
2674:
2593:
2568:
2536:
2503:
2479:
2454:
2351:
2326:
2302:
2277:
2253:
2228:
2204:
2179:
2106:
2072:"Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming"
2071:
2047:
2012:
1893:
1873:"Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation"
1872:
1791:
1766:
1374:
1341:
1317:
1292:
1268:
1243:
1219:
1194:
1096:
1071:
960:
1829:"Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration"
1676:
1659:
1459:
1434:
1293:"Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells"
1170:
1145:
1048:
8059:
6474:
5814:
4239:
4027:
3355:
2553:
1980:
1963:
1884:
1627:
826:
1751:
1592:
1476:
8024:
7336:
7219:
7211:
6582:
6538:
5541:
5389:
2412:
Baeyens L, Bonné S, German MS, Ravassard P, Heimberg H, Bouwens L (November 2006).
2164:
1693:
1242:
Rea J, Menci V, Tollis P, Santini T, Armaos A, Garone MG, et al. (July 2020).
1195:"Expression and actions of transcription factors in adult hippocampal neurogenesis"
897:
830:
787:
761:
709:
607:
578:
534:
530:
515:
2129:
Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, et al. (January 2008).
1997:
1527:
622:. Ngn1 is a proneural gene because its expression is seen prior to neural lineage
2096:
2037:
1782:
1765:
Ma YC, Song MR, Park JP, Henry Ho HY, Hu L, Kurtev MV, et al. (April 2008).
1734:
1717:
1087:
719:
through binding the STAT1/3 complex, which is activated through the LIF pathway.
388:
247:
106:
7708:
7311:
5791:
5506:
5471:
3860:
3665:
3660:
2907:
2902:
2798:
2678:
1072:"Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation"
733:
693:
451:
310:
169:
2584:
2147:
2130:
1259:
8020:
7971:
7443:
7047:
6956:
6936:
6909:
6256:
6005:
5854:
5842:
5837:
4836:
4831:
3595:
3590:
3568:
3434:
3252:
2956:
2897:
2892:
2872:
2569:"Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells"
2371:
1308:
944:
936:
682:
678:
487:
395:
254:
113:
1767:"Regulation of motor neuron specification by phosphorylation of neurogenin 2"
1660:"Cracking the transcriptional code for cell specification in the neural tube"
1070:
Hulme AJ, Maksour S, St-Clair Glover M, Miellet S, Dottori M (January 2022).
7894:
7884:
7867:
7341:
6360:
4065:
3494:
3152:
1291:
Chen ZA, Wang JL, Liu RT, Ren JP, Wen LQ, Chen XJ, et al. (July 2009).
940:
903:
757:
689:
2602:
2545:
2488:
2439:
2430:
2413:
2379:
2360:
2311:
2262:
2213:
2156:
2115:
2056:
1989:
1948:
1939:
1922:
1902:
1854:
1800:
1743:
1685:
1584:
1519:
1468:
1383:
1326:
1277:
1228:
1179:
1161:
1105:
2383:. If this is an intentional citation to a retracted paper, please replace
2195:
1365:
1056:
17:
7361:
7139:
5501:
4060:
4017:
3069:
2470:
1845:
1828:
1607:
1398:
969:
919:
911:
906:
696:
protein expression. This is critical for the initiation of neurogenesis.
400:
259:
118:
2527:
2504:"In vivo reprogramming of adult pancreatic exocrine cells to beta-cells"
2244:
1718:"Neurogenesis or neuronal specification: phosphorylation strikes again!"
1511:
7761:
7741:
7736:
7448:
5422:
5206:
3118:
3113:
3108:
3096:
3091:
2293:
1611:
1402:
1210:
1005:
to activate the Pax4 promoter to induce specific cell differentiation.
986:
959:
The Notch pathway is one of the key modulators of Ngn3. The binding of
885:
833:, indicating that Ngn2 plays a role in specification of these neurons.
619:
340:
325:
199:
184:
50:
35:
914:
cells are formed. There are several pathways that Ngn3 works through.
7942:
7937:
7932:
7922:
7917:
7636:
7191:
7186:
7181:
7176:
6442:
6437:
6314:
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6280:
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3397:
3281:
3086:
2976:
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2939:
2934:
2860:
2342:
972:
sequence that allow for the regulation of this transcription factor.
877:
810:
686:
659:
511:
491:
383:
242:
101:
1576:
2502:
Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (October 2008).
7986:
7964:
7959:
7927:
7816:
7811:
7756:
7751:
7746:
7690:
7599:
7594:
7589:
7584:
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7569:
7564:
7512:
7507:
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7485:
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7458:
7453:
7422:
7389:
7384:
7379:
7326:
7321:
7316:
7291:
7249:
7244:
7239:
7234:
7229:
7224:
7196:
7149:
7144:
7090:
7085:
7080:
7075:
7052:
6827:
6812:
6807:
6802:
6797:
6792:
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6752:
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6732:
6727:
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6712:
6707:
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6682:
6677:
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6632:
6622:
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6602:
6597:
6592:
6587:
6521:
6516:
6511:
6484:
6459:
6427:
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6415:
6321:
6299:
6294:
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6244:
6239:
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6229:
6124:
6119:
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6057:
6052:
6037:
6010:
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5626:
5621:
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5611:
5606:
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5581:
5576:
5571:
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5536:
5531:
5526:
5521:
5516:
5511:
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5491:
5316:
5304:
5299:
5294:
5289:
5257:
5252:
5051:
5041:
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5031:
5026:
5021:
5011:
5006:
5001:
4996:
4912:
4902:
4895:
4890:
4885:
4880:
4870:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4705:
4700:
4695:
4639:
4634:
4533:
4512:
4507:
4381:
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4371:
4366:
4361:
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3563:
3328:
3323:
3318:
3308:
3303:
3298:
3288:
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2833:
2828:
2823:
2818:
2813:
2803:
2791:
2786:
2764:
2754:
2749:
2739:
2455:"Reprogramming of human pancreatic exocrine cells to β-like cells"
2227:
Figeac F, Ilias A, Bailbe D, Portha B, Movassat J (October 2012).
1002:
814:
651:
647:
603:
495:
8013:
8008:
8003:
7993:
7981:
7976:
7823:
7806:
7670:
7665:
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7631:
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7554:
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7524:
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7369:
7331:
7306:
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7296:
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7171:
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7015:
7010:
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6973:
6961:
6951:
6946:
6929:
6924:
6919:
6902:
6897:
6892:
6867:
6862:
6857:
6575:
6570:
6565:
6560:
6555:
6494:
6469:
6464:
6405:
6400:
6395:
6390:
6385:
6380:
6375:
6370:
6365:
6336:
6331:
6224:
6219:
6214:
6209:
6195:
6190:
6185:
6180:
6175:
6146:
6141:
6136:
6102:
6097:
6092:
6087:
6082:
6077:
6042:
6030:
6025:
6020:
5973:
5968:
5963:
5958:
5953:
5874:
5859:
5849:
5825:
5820:
5806:
5801:
5796:
5786:
5781:
5769:
5764:
5708:
5703:
5481:
5466:
5461:
5449:
5444:
5277:
5272:
5267:
5111:
5046:
4991:
4986:
4981:
4865:
4860:
4855:
4779:
4774:
4769:
4764:
4759:
4754:
4749:
4744:
4739:
4722:
4717:
4661:
4656:
4624:
4619:
4614:
4604:
4599:
4592:
4587:
4582:
4577:
4567:
4562:
4545:
4403:
4398:
4393:
4321:
3782:
3777:
3772:
3767:
3762:
3757:
3670:
3655:
3632:
3605:
3578:
3573:
3538:
3516:
3511:
3506:
3489:
3484:
3474:
3464:
3414:
3372:
3367:
3350:
3345:
3340:
3238:
3233:
3221:
3179:
3174:
3164:
3079:
3074:
3064:
2983:
2966:
2929:
2917:
2912:
2887:
2845:
2774:
2769:
2744:
2727:
2722:
2717:
2712:
2707:
2697:
998:
965:
881:
862:
853:(Lhx3), genes related to V2 interneuron identity are expressed.
850:
760:
that the repression of Ngn1 by Notch, promotes glial lineage in
728:
584:
479:
471:
376:
235:
94:
7784:
7113:
5355:
3855:
2657:
2615:
1871:
Li HJ, Ray SK, Singh NK, Johnston B, Leiter AB (October 2011).
1435:"Neuronal differentiation: proneural genes inhibit gliogenesis"
650:
transcriptional co-activator complex, which recruits it to the
7655:
7284:
7274:
7154:
6550:
6107:
5456:
4907:
4644:
4138:
3610:
3439:
3429:
3424:
3216:
3211:
865:(Isl1) proteins and each Isl1 is bound by Lhx3 is called the
611:
918:
place to investigate Ngn3's possible role as a treatment for
1037:
610:. In order for Ngn1 to bind with high fidelity with genomic
626:, indicating it plays a role in neuronal differentiation.
673:(BMP) signaling is responsible for the expression of the
1964:"Transcriptional regulation of α-cell differentiation"
506:
Neurogenins primarily govern the transition of neural
712:
activation. Normally, the STAT binding site promotes
1144:
Ma Q, Fode C, Guillemot F, Anderson DJ (July 1999).
7903:
7863:
7832:
7797:
7722:
7699:
7681:
7431:
7405:
7357:
7260:
7207:
7127:
7061:
6878:
6838:
6534:
6351:
5991:
5717:
5405:
5386:
5374:
5325:
5238:
5217:
4419:
4339:
4310:
4290:
4265:
4228:
4147:
4043:
3891:
3872:
3798:
3743:
3641:
3551:
3527:
3450:
3383:
3247:
3197:
3006:
2992:
2670:
2567:Sancho R, Gruber R, Gu G, Behrens A (August 2014).
447:
437:
432:
411:
406:
394:
382:
370:
358:
346:
336:
331:
324:
306:
296:
291:
270:
265:
253:
241:
229:
217:
205:
195:
190:
183:
165:
155:
150:
129:
124:
112:
100:
88:
76:
64:
56:
46:
41:
34:
1633:(Third ed.). Boston: Academic Press. p.
951:to become an endocrine multipotent pro-precursor.
880:, S231 and S234, which can be phosphorylated by
533:cells, the neurogenin family is essential for
8046:transcription factor/coregulator deficiencies
7117:β-Scaffold factors with minor groove contacts
2627:
8:
1822:
1820:
1818:
1816:
1814:
1812:
1810:
1606:Universal protein resource accession number
1397:Universal protein resource accession number
708:(LIF) pathway is inhibited by Ngn1 blocking
1428:
1426:
1424:
1422:
1420:
1418:
1416:
1414:
1412:
922:and regeneration of cells in the pancreas.
7794:
7781:
7124:
7110:
5402:
5383:
5371:
5352:
3888:
3869:
3852:
3003:
2667:
2654:
2634:
2620:
2612:
2397:|...|intentional=yes}}
1030:
1028:
1026:
606:that encode transcriptional regulators of
429:
288:
147:
2592:
2535:
2478:
2429:
2350:
2301:
2252:
2203:
2146:
2105:
2095:
2046:
2036:
1979:
1962:Bramswig NC, Kaestner KH (October 2011).
1938:
1916:
1914:
1912:
1892:
1844:
1790:
1733:
1675:
1458:
1373:
1316:
1267:
1218:
1169:
1095:
634:In E14 rats, when Ngn1 is present in the
1658:Marquardt T, Pfaff SL (September 2001).
1542:"Neurogenin-1 Products: R&D Systems"
861:A dimer of the adaptor NLI bound to two
541:and development of the sensory lineage.
1022:
1711:
1709:
1707:
1705:
1703:
591:that acts as a regulator for neuronal
321:
180:
31:
1866:
1864:
7:
1625:Harris WA, Sanes DH, Reh TA (2011).
1123:. New York: Kluwer Academic/Plenum.
943:, pancreatic polypeptide cells, and
3800:(1.6) Basic helix-span-helix (bHSH)
1193:Hodge RD, Hevner RF (August 2011).
987:neurogenic differentiation factor 1
1968:Diabetes, Obesity & Metabolism
1877:Diabetes, Obesity & Metabolism
25:
1827:Rukstalis JM, Habener JF (2009).
1716:Lai HC, Johnson JE (April 2008).
1629:Development of the Nervous System
801:Neurogenesis and glial inhibition
583:Neurogenin 1 (Ngn1) is a Class-A
545:Regulation of neurogenic cascades
1981:10.1111/j.1463-1326.2011.01440.x
1885:10.1111/j.1463-1326.2011.01438.x
1552:from the original on 2014-01-16.
930:Phases of pancreatic development
7787:(0) Other transcription factors
7071:transcriptional enhancer factor
2688:Activating transcription factor
2459:Cell Death and Differentiation
2418:Cell Death and Differentiation
968:binding sites adjacent to the
1:
7001:Interferon regulatory factors
5240:(2.5) Alternating composition
4436:General transcription factors
1677:10.1016/S0092-8674(01)00499-8
1460:10.1016/S0960-9822(01)00191-9
1049:10.1016/S1357-2725(97)89968-2
825:Mice lacking Ngn2 have fewer
704:In the presence of Ngn1, the
675:transcriptional co-activators
8076:Genes on human chromosome 10
6286:Octamer transcription factor
2994:(1.2) Basic helix-loop-helix
2097:10.1371/journal.pone.0037055
2038:10.1371/journal.pone.0133862
1783:10.1016/j.neuron.2008.01.037
1735:10.1016/j.neuron.2008.03.023
1565:Nature Reviews. Neuroscience
1088:10.1016/j.stemcr.2021.11.015
997:Another important target is
955:Modulation via notch pathway
654:upstream of the gene in the
563:neurodevelopmental disorders
8071:Genes on human chromosome 4
8066:Genes on human chromosome 5
3060:Myogenic regulatory factors
1119:Rao MS, Jacobson M (2005).
985:Ngn3 can also activate the
949:pancreatic progenitor cells
8092:
2585:10.1016/j.stem.2014.06.019
2148:10.1016/j.cell.2007.12.015
1260:10.1038/s41419-020-02738-w
1199:Developmental Neurobiology
1121:Developmental Neurobiology
976:Downstream targets of Ngn3
895:
882:glycogen synthase kinase 3
797:with an enhancer protein.
785:
706:leukemia inhibitory factor
671:Bone-morphogenetic-protein
576:
567:neurodegenerative diseases
8041:
7793:
7780:
7123:
7109:
6880:(3.5) Tryptophan clusters
5370:
5351:
3868:
3851:
2666:
2653:
2372:10.1038/s41587-020-0426-2
1309:10.1007/s10616-009-9226-8
595:, and acts by binding to
428:
287:
146:
7701:(4.10) Cold-shock domain
2184:Cell Death & Disease
1879:. 13 Suppl 1 (1): 5–12.
1433:Morrison SJ (May 2001).
1248:Cell Death & Disease
630:Neuronal differentiation
482:families related to the
2647:intracellular receptors
2282:Journal of Cell Science
1150:Genes & Development
807:neural progenitor cells
681:through binding of all
466:, often abbreviated as
2431:10.1038/sj.cdd.4401883
1940:10.1507/endocrj.51.255
1921:Watada H (June 2004).
1401:for "Neurogenin-1" at
1348:Caenorhabditis elegans
1162:10.1101/gad.13.13.1717
851:LIM homeobox protein 3
766:central nervous system
585:basic-helix-loop-helix
7410:TATA-binding proteins
2643:Transcription factors
2389:|...}}
2366:(Retracted, see
2196:10.1038/cddis.2013.52
1366:10.1534/g3.120.401126
723:Glial differentiation
557:Clinical implications
551:transcription factors
475:transcription factors
2471:10.1038/cdd.2014.193
2331:Nature Biotechnology
2288:(Pt 16): 2792–2802.
1846:10.4161/isl.1.3.9877
821:Neural specification
589:transcription factor
7905:(0.6) Miscellaneous
7436:High-mobility group
7132:Rel homology region
4122:Testicular receptor
3863:DNA-binding domains
2528:10.1038/nature07314
2520:2008Natur.455..627Z
2245:10.1038/mt.2012.112
2088:2012PLoSO...737055S
2029:2015PLoSO..1033862G
1512:10.1038/nature09611
1504:2010Natur.468..214R
1451:2001CBio...11.R349M
845:V2 interneuron fate
748:Regulation by Notch
600:regulatory elements
539:dorsal root ganglia
7270:p53 p63 p73 family
6843:Heat shock factors
2294:10.1242/jcs.065268
1974:(Suppl 1): 13–20.
1546:www.rndsystems.com
1211:10.1002/dneu.20882
752:Activation of the
638:, it binds to the
618:with another bHLH
537:in the developing
470:, are a family of
8053:
8052:
8037:
8036:
8033:
8032:
7776:
7775:
7772:
7771:
7105:
7104:
7101:
7100:
6347:
6346:
5987:
5986:
5347:
5346:
5343:
5342:
4335:
4334:
4191:Mineralocorticoid
3847:
3846:
3843:
3842:
3547:
3546:
2660:(1) Basic domains
2514:(7213): 627–632.
2424:(11): 1892–1899.
2239:(10): 1944–1952.
2233:Molecular Therapy
1927:Endocrine Journal
1644:978-0-12-374539-2
1498:(7321): 214–222.
1156:(13): 1717–1728.
1076:Stem Cell Reports
1043:(12): 1389–1399.
999:paired box gene 4
857:Motor neuron fate
837:Pan-neuronal fate
773:Regulation by LIF
740:Regulation by BMP
700:Regulation by LIF
666:Regulation by BMP
526:nervous systems.
461:
460:
457:
456:
320:
319:
316:
315:
179:
178:
175:
174:
16:(Redirected from
8083:
7877:-related factors
7795:
7782:
7683:(4.9) Grainyhead
7125:
7111:
7063:(3.6) TEA domain
6353:(3.2) Paired box
5994:
5728:
5722:
5416:
5410:
5403:
5399:
5393:
5384:
5372:
5361:Helix-turn-helix
5353:
4315:
4295:
4270:
4233:
4203:Estrogen related
4152:
4048:
3896:
3889:
3877:Nuclear receptor
3870:
3853:
3532:
3453:
3386:
3255:
3200:
3009:
3004:
2668:
2655:
2636:
2629:
2622:
2613:
2607:
2606:
2596:
2564:
2558:
2557:
2539:
2499:
2493:
2492:
2482:
2465:(7): 1117–1130.
2450:
2444:
2443:
2433:
2409:
2403:
2402:
2400:
2398:
2390:
2364:
2354:
2343:10.1038/nbt.2747
2322:
2316:
2315:
2305:
2273:
2267:
2266:
2256:
2224:
2218:
2217:
2207:
2175:
2169:
2168:
2150:
2126:
2120:
2119:
2109:
2099:
2067:
2061:
2060:
2050:
2040:
2008:
2002:
2001:
1983:
1959:
1953:
1952:
1942:
1918:
1907:
1906:
1896:
1868:
1859:
1858:
1848:
1824:
1805:
1804:
1794:
1762:
1756:
1755:
1737:
1713:
1698:
1697:
1679:
1655:
1649:
1648:
1632:
1622:
1616:
1615:
1603:
1597:
1596:
1560:
1554:
1553:
1538:
1532:
1531:
1487:
1481:
1480:
1462:
1445:(9): R349–R351.
1430:
1407:
1406:
1394:
1388:
1387:
1377:
1360:(6): 1949–1962.
1337:
1331:
1330:
1320:
1303:(1–3): 125–132.
1288:
1282:
1281:
1271:
1239:
1233:
1232:
1222:
1190:
1184:
1183:
1173:
1141:
1135:
1134:
1116:
1110:
1109:
1099:
1067:
1061:
1060:
1032:
508:progenitor cells
430:
322:
289:
181:
148:
32:
21:
8091:
8090:
8086:
8085:
8084:
8082:
8081:
8080:
8056:
8055:
8054:
8049:
8029:
7899:
7859:
7828:
7789:
7768:
7718:
7695:
7677:
7427:
7401:
7353:
7256:
7203:
7119:
7097:
7057:
6874:
6834:
6530:
6343:
5992:
5983:
5724:
5723:
5718:
5713:
5412:
5411:
5406:
5395:
5394:
5387:
5366:
5339:
5321:
5234:
5222:
5213:
4428:
4424:
4415:
4344:
4341:(2.2) Other Cys
4331:
4311:
4306:
4291:
4286:
4266:
4261:
4229:
4224:
4159:Steroid hormone
4148:
4143:
4044:
4039:
3903:Thyroid hormone
3892:
3883:
3864:
3839:
3794:
3739:
3637:
3543:
3530:
3528:
3523:
3451:
3446:
3384:
3379:
3250:
3248:
3243:
3198:
3193:
3007:
2988:
2662:
2649:
2640:
2610:
2566:
2565:
2561:
2501:
2500:
2496:
2452:
2451:
2447:
2411:
2410:
2406:
2392:
2384:
2382:
2365:
2324:
2323:
2319:
2275:
2274:
2270:
2226:
2225:
2221:
2177:
2176:
2172:
2128:
2127:
2123:
2069:
2068:
2064:
2023:(8): e0133862.
2010:
2009:
2005:
1961:
1960:
1956:
1920:
1919:
1910:
1870:
1869:
1862:
1826:
1825:
1808:
1764:
1763:
1759:
1715:
1714:
1701:
1657:
1656:
1652:
1645:
1624:
1623:
1619:
1605:
1604:
1600:
1577:10.1038/nrn1219
1571:(10): 795–805.
1562:
1561:
1557:
1540:
1539:
1535:
1489:
1488:
1484:
1439:Current Biology
1432:
1431:
1410:
1396:
1395:
1391:
1350:Nervous System"
1339:
1338:
1334:
1290:
1289:
1285:
1241:
1240:
1236:
1192:
1191:
1187:
1143:
1142:
1138:
1131:
1118:
1117:
1113:
1069:
1068:
1064:
1034:
1033:
1024:
1020:
1011:
995:
983:
978:
957:
932:
900:
894:
867:LIM-homeodomain
859:
847:
839:
823:
803:
790:
784:
775:
750:
742:
725:
702:
668:
636:cerebral cortex
632:
593:differentiation
581:
575:
559:
547:
504:
28:
23:
22:
15:
12:
11:
5:
8089:
8087:
8079:
8078:
8073:
8068:
8058:
8057:
8051:
8050:
8042:
8039:
8038:
8035:
8034:
8031:
8030:
8028:
8027:
8018:
8017:
8016:
8011:
8006:
7996:
7991:
7990:
7989:
7984:
7979:
7969:
7968:
7967:
7962:
7952:
7947:
7946:
7945:
7940:
7935:
7930:
7925:
7920:
7909:
7907:
7901:
7900:
7898:
7897:
7892:
7887:
7881:
7879:
7861:
7860:
7858:
7857:
7852:
7847:
7841:
7839:
7830:
7829:
7827:
7826:
7821:
7820:
7819:
7814:
7803:
7801:
7791:
7790:
7785:
7778:
7777:
7774:
7773:
7770:
7769:
7767:
7766:
7765:
7764:
7759:
7754:
7749:
7744:
7739:
7728:
7726:
7720:
7719:
7717:
7716:
7711:
7705:
7703:
7697:
7696:
7694:
7693:
7687:
7685:
7679:
7678:
7676:
7675:
7674:
7673:
7668:
7663:
7658:
7648:
7647:
7646:
7641:
7640:
7639:
7634:
7629:
7614:
7609:
7604:
7603:
7602:
7597:
7592:
7587:
7582:
7577:
7572:
7567:
7562:
7557:
7552:
7547:
7542:
7537:
7532:
7527:
7517:
7516:
7515:
7510:
7500:
7499:
7498:
7493:
7488:
7483:
7473:
7472:
7471:
7466:
7461:
7456:
7446:
7440:
7438:
7429:
7428:
7426:
7425:
7420:
7414:
7412:
7403:
7402:
7400:
7399:
7394:
7393:
7392:
7387:
7382:
7377:
7366:
7364:
7355:
7354:
7352:
7351:
7346:
7345:
7344:
7339:
7334:
7329:
7324:
7319:
7314:
7309:
7304:
7299:
7289:
7288:
7287:
7282:
7277:
7266:
7264:
7262:(4.3) p53-like
7258:
7257:
7255:
7254:
7253:
7252:
7247:
7242:
7237:
7232:
7227:
7216:
7214:
7205:
7204:
7202:
7201:
7200:
7199:
7194:
7189:
7184:
7179:
7169:
7168:
7167:
7162:
7157:
7152:
7147:
7136:
7134:
7121:
7120:
7114:
7107:
7106:
7103:
7102:
7099:
7098:
7096:
7095:
7094:
7093:
7088:
7083:
7078:
7067:
7065:
7059:
7058:
7056:
7055:
7050:
7045:
7044:
7043:
7038:
7033:
7028:
7023:
7018:
7013:
7008:
6998:
6993:
6992:
6991:
6986:
6981:
6976:
6966:
6965:
6964:
6959:
6954:
6949:
6939:
6934:
6933:
6932:
6927:
6922:
6912:
6907:
6906:
6905:
6900:
6895:
6884:
6882:
6876:
6875:
6873:
6872:
6871:
6870:
6865:
6860:
6847:
6845:
6836:
6835:
6833:
6832:
6831:
6830:
6825:
6820:
6815:
6810:
6805:
6800:
6795:
6790:
6785:
6780:
6775:
6770:
6765:
6760:
6755:
6750:
6745:
6740:
6735:
6730:
6725:
6720:
6715:
6710:
6705:
6700:
6695:
6690:
6685:
6680:
6675:
6670:
6665:
6660:
6655:
6650:
6645:
6640:
6635:
6630:
6625:
6620:
6615:
6610:
6605:
6600:
6595:
6590:
6580:
6579:
6578:
6573:
6568:
6563:
6558:
6547:
6545:
6532:
6531:
6529:
6528:
6527:
6526:
6525:
6524:
6519:
6514:
6504:
6503:
6502:
6497:
6487:
6482:
6472:
6467:
6462:
6457:
6452:
6447:
6446:
6445:
6440:
6430:
6425:
6424:
6423:
6418:
6410:
6409:
6408:
6403:
6398:
6393:
6388:
6383:
6378:
6373:
6368:
6357:
6355:
6349:
6348:
6345:
6344:
6342:
6341:
6340:
6339:
6334:
6324:
6319:
6318:
6317:
6312:
6307:
6302:
6297:
6292:
6283:
6278:
6273:
6264:
6254:
6253:
6252:
6247:
6242:
6237:
6232:
6227:
6222:
6217:
6212:
6202:
6201:
6200:
6199:
6198:
6193:
6188:
6183:
6178:
6168:
6167:
6166:
6161:
6151:
6150:
6149:
6144:
6139:
6129:
6128:
6127:
6122:
6112:
6111:
6110:
6105:
6100:
6095:
6090:
6085:
6080:
6067:
6062:
6061:
6060:
6055:
6045:
6040:
6035:
6034:
6033:
6028:
6023:
6013:
6008:
6003:
5997:
5995:
5989:
5988:
5985:
5984:
5982:
5981:
5976:
5971:
5966:
5961:
5956:
5951:
5950:
5949:
5944:
5939:
5934:
5929:
5924:
5919:
5914:
5909:
5904:
5899:
5889:
5884:
5883:
5882:
5877:
5867:
5862:
5857:
5852:
5847:
5846:
5845:
5840:
5830:
5829:
5828:
5823:
5811:
5810:
5809:
5804:
5799:
5794:
5789:
5784:
5774:
5773:
5772:
5767:
5757:
5752:
5747:
5742:
5737:
5731:
5729:
5715:
5714:
5712:
5711:
5706:
5701:
5696:
5695:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5659:
5654:
5649:
5644:
5639:
5634:
5629:
5624:
5619:
5614:
5609:
5604:
5599:
5594:
5589:
5584:
5579:
5574:
5569:
5564:
5559:
5554:
5549:
5544:
5539:
5534:
5529:
5524:
5519:
5514:
5509:
5499:
5494:
5489:
5484:
5480:extended Hox:
5478:
5477:
5476:
5475:
5474:
5469:
5464:
5454:
5453:
5452:
5442:
5441:
5440:
5435:
5419:
5417:
5400:
5381:
5368:
5367:
5356:
5349:
5348:
5345:
5344:
5341:
5340:
5338:
5337:
5331:
5329:
5323:
5322:
5320:
5319:
5314:
5313:
5312:
5307:
5302:
5297:
5292:
5282:
5281:
5280:
5275:
5270:
5260:
5255:
5250:
5244:
5242:
5236:
5235:
5233:
5232:
5226:
5224:
5220:
5215:
5214:
5212:
5211:
5210:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5149:
5144:
5139:
5134:
5129:
5124:
5119:
5114:
5109:
5104:
5099:
5094:
5089:
5084:
5079:
5074:
5069:
5064:
5059:
5054:
5049:
5044:
5039:
5034:
5029:
5024:
5019:
5014:
5009:
5004:
4999:
4994:
4989:
4984:
4974:
4973:
4972:
4967:
4962:
4957:
4952:
4947:
4942:
4937:
4927:
4926:
4925:
4920:
4910:
4905:
4900:
4899:
4898:
4893:
4888:
4883:
4873:
4868:
4863:
4858:
4853:
4852:
4851:
4850:
4849:
4844:
4839:
4834:
4829:
4819:
4818:
4817:
4812:
4807:
4802:
4797:
4792:
4787:
4782:
4777:
4772:
4767:
4762:
4757:
4752:
4747:
4742:
4727:
4726:
4725:
4720:
4710:
4709:
4708:
4703:
4698:
4688:
4687:
4686:
4681:
4676:
4666:
4665:
4664:
4659:
4649:
4648:
4647:
4642:
4637:
4632:
4627:
4622:
4617:
4607:
4602:
4597:
4596:
4595:
4590:
4585:
4580:
4570:
4565:
4560:
4559:
4558:
4553:
4548:
4536:
4530:
4529:
4528:
4527:
4526:
4525:
4520:
4515:
4510:
4505:
4500:
4495:
4490:
4480:
4475:
4470:
4469:
4468:
4463:
4453:
4448:
4443:
4432:
4430:
4426:
4422:
4417:
4416:
4414:
4413:
4408:
4407:
4406:
4401:
4396:
4386:
4385:
4384:
4379:
4374:
4369:
4364:
4359:
4348:
4346:
4342:
4337:
4336:
4333:
4332:
4330:
4329:
4324:
4318:
4316:
4308:
4307:
4305:
4304:
4298:
4296:
4288:
4287:
4285:
4284:
4279:
4273:
4271:
4263:
4262:
4260:
4259:
4258:
4257:
4252:
4247:
4236:
4234:
4226:
4225:
4223:
4222:
4221:
4220:
4215:
4210:
4200:
4199:
4198:
4193:
4188:
4186:Glucocorticoid
4183:
4182:
4181:
4176:
4166:
4155:
4153:
4145:
4144:
4142:
4141:
4136:
4135:
4134:
4129:
4119:
4118:
4117:
4112:
4107:
4097:
4092:
4091:
4090:
4085:
4075:
4070:
4069:
4068:
4063:
4051:
4049:
4041:
4040:
4038:
4037:
4032:
4031:
4030:
4025:
4015:
4014:
4013:
4008:
4003:
3993:
3992:
3991:
3986:
3981:
3971:
3966:
3965:
3964:
3959:
3954:
3944:
3943:
3942:
3937:
3927:
3922:
3917:
3916:
3915:
3910:
3899:
3897:
3886:
3881:
3866:
3865:
3856:
3849:
3848:
3845:
3844:
3841:
3840:
3838:
3837:
3836:
3835:
3830:
3825:
3820:
3815:
3804:
3802:
3796:
3795:
3793:
3792:
3791:
3790:
3785:
3780:
3775:
3770:
3765:
3760:
3749:
3747:
3741:
3740:
3738:
3737:
3736:
3735:
3729:
3728:
3727:
3722:
3712:
3711:
3710:
3705:
3700:
3695:
3690:
3675:
3674:
3673:
3668:
3663:
3658:
3647:
3645:
3639:
3638:
3636:
3635:
3630:
3629:
3628:
3623:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3582:
3581:
3576:
3566:
3560:
3558:
3549:
3548:
3545:
3544:
3542:
3541:
3535:
3533:
3525:
3524:
3522:
3521:
3520:
3519:
3514:
3509:
3499:
3498:
3497:
3492:
3487:
3482:
3477:
3472:
3467:
3456:
3454:
3448:
3447:
3445:
3444:
3443:
3442:
3437:
3432:
3427:
3417:
3412:
3411:
3410:
3405:
3400:
3389:
3387:
3381:
3380:
3378:
3377:
3376:
3375:
3370:
3360:
3359:
3358:
3353:
3348:
3343:
3333:
3332:
3331:
3326:
3321:
3313:
3312:
3311:
3306:
3301:
3291:
3286:
3285:
3284:
3279:
3269:
3264:
3258:
3256:
3245:
3244:
3242:
3241:
3236:
3231:
3230:
3229:
3224:
3219:
3209:
3203:
3201:
3195:
3194:
3192:
3191:
3186:
3185:
3184:
3183:
3182:
3177:
3167:
3157:
3156:
3155:
3150:
3140:
3139:
3138:
3133:
3123:
3122:
3121:
3116:
3111:
3101:
3100:
3099:
3094:
3084:
3083:
3082:
3077:
3072:
3067:
3057:
3052:
3051:
3050:
3045:
3035:
3030:
3029:
3028:
3023:
3012:
3010:
3001:
2990:
2989:
2987:
2986:
2981:
2980:
2979:
2974:
2969:
2959:
2954:
2949:
2948:
2947:
2942:
2937:
2932:
2922:
2921:
2920:
2915:
2910:
2905:
2895:
2890:
2885:
2880:
2875:
2870:
2865:
2864:
2863:
2858:
2853:
2843:
2842:
2841:
2836:
2831:
2826:
2821:
2816:
2806:
2801:
2796:
2795:
2794:
2789:
2779:
2778:
2777:
2772:
2767:
2762:
2757:
2752:
2747:
2742:
2732:
2731:
2730:
2725:
2720:
2715:
2710:
2705:
2700:
2695:
2684:
2682:
2675:leucine zipper
2664:
2663:
2658:
2651:
2650:
2641:
2639:
2638:
2631:
2624:
2616:
2609:
2608:
2579:(2): 139–153.
2573:Cell Stem Cell
2559:
2494:
2445:
2404:
2317:
2268:
2219:
2170:
2141:(2): 197–207.
2121:
2062:
2003:
1954:
1933:(3): 255–264.
1908:
1860:
1839:(3): 177–184.
1806:
1757:
1699:
1670:(6): 651–654.
1650:
1643:
1617:
1598:
1555:
1533:
1482:
1408:
1389:
1332:
1297:Cytotechnology
1283:
1234:
1205:(8): 680–689.
1185:
1136:
1129:
1111:
1062:
1021:
1019:
1016:
1010:
1007:
994:
991:
982:
979:
977:
974:
956:
953:
931:
928:
896:Main article:
893:
890:
871:phosphorylated
858:
855:
846:
843:
838:
835:
822:
819:
802:
799:
786:Main article:
783:
780:
774:
771:
749:
746:
741:
738:
724:
721:
701:
698:
667:
664:
631:
628:
577:Main article:
574:
571:
558:
555:
546:
543:
503:
500:
459:
458:
455:
454:
449:
445:
444:
439:
435:
434:
426:
425:
415:
409:
408:
404:
403:
398:
392:
391:
386:
380:
379:
374:
368:
367:
362:
356:
355:
350:
344:
343:
338:
334:
333:
329:
328:
318:
317:
314:
313:
308:
304:
303:
298:
294:
293:
285:
284:
274:
268:
267:
263:
262:
257:
251:
250:
245:
239:
238:
233:
227:
226:
221:
215:
214:
209:
203:
202:
197:
193:
192:
188:
187:
177:
176:
173:
172:
167:
163:
162:
157:
153:
152:
144:
143:
133:
127:
126:
122:
121:
116:
110:
109:
104:
98:
97:
92:
86:
85:
80:
74:
73:
68:
62:
61:
58:
54:
53:
48:
44:
43:
39:
38:
27:Protein family
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
8088:
8077:
8074:
8072:
8069:
8067:
8064:
8063:
8061:
8048:
8047:
8040:
8026:
8022:
8019:
8015:
8012:
8010:
8007:
8005:
8002:
8001:
8000:
7997:
7995:
7992:
7988:
7985:
7983:
7980:
7978:
7975:
7974:
7973:
7970:
7966:
7963:
7961:
7958:
7957:
7956:
7953:
7951:
7948:
7944:
7941:
7939:
7936:
7934:
7931:
7929:
7926:
7924:
7921:
7919:
7916:
7915:
7914:
7911:
7910:
7908:
7906:
7902:
7896:
7893:
7891:
7888:
7886:
7883:
7882:
7880:
7878:
7875:
7872:
7869:
7866:
7862:
7856:
7853:
7851:
7848:
7846:
7843:
7842:
7840:
7838:
7837:Pocket domain
7835:
7831:
7825:
7822:
7818:
7815:
7813:
7810:
7809:
7808:
7805:
7804:
7802:
7800:
7799:(0.2) HMGI(Y)
7796:
7792:
7788:
7783:
7779:
7763:
7760:
7758:
7755:
7753:
7750:
7748:
7745:
7743:
7740:
7738:
7735:
7734:
7733:
7730:
7729:
7727:
7725:
7721:
7715:
7712:
7710:
7707:
7706:
7704:
7702:
7698:
7692:
7689:
7688:
7686:
7684:
7680:
7672:
7669:
7667:
7664:
7662:
7659:
7657:
7654:
7653:
7652:
7649:
7645:
7642:
7638:
7635:
7633:
7630:
7628:
7625:
7624:
7623:
7620:
7619:
7618:
7615:
7613:
7610:
7608:
7605:
7601:
7598:
7596:
7593:
7591:
7588:
7586:
7583:
7581:
7578:
7576:
7573:
7571:
7568:
7566:
7563:
7561:
7558:
7556:
7553:
7551:
7548:
7546:
7543:
7541:
7538:
7536:
7533:
7531:
7528:
7526:
7523:
7522:
7521:
7518:
7514:
7511:
7509:
7506:
7505:
7504:
7501:
7497:
7494:
7492:
7489:
7487:
7484:
7482:
7479:
7478:
7477:
7474:
7470:
7467:
7465:
7462:
7460:
7457:
7455:
7452:
7451:
7450:
7447:
7445:
7442:
7441:
7439:
7437:
7434:
7430:
7424:
7421:
7419:
7416:
7415:
7413:
7411:
7408:
7404:
7398:
7395:
7391:
7388:
7386:
7383:
7381:
7378:
7376:
7373:
7372:
7371:
7368:
7367:
7365:
7363:
7360:
7356:
7350:
7347:
7343:
7340:
7338:
7335:
7333:
7330:
7328:
7325:
7323:
7320:
7318:
7315:
7313:
7310:
7308:
7305:
7303:
7300:
7298:
7295:
7294:
7293:
7290:
7286:
7283:
7281:
7278:
7276:
7273:
7272:
7271:
7268:
7267:
7265:
7263:
7259:
7251:
7248:
7246:
7243:
7241:
7238:
7236:
7233:
7231:
7228:
7226:
7223:
7222:
7221:
7218:
7217:
7215:
7213:
7210:
7206:
7198:
7195:
7193:
7190:
7188:
7185:
7183:
7180:
7178:
7175:
7174:
7173:
7170:
7166:
7163:
7161:
7158:
7156:
7153:
7151:
7148:
7146:
7143:
7142:
7141:
7138:
7137:
7135:
7133:
7130:
7126:
7122:
7118:
7112:
7108:
7092:
7089:
7087:
7084:
7082:
7079:
7077:
7074:
7073:
7072:
7069:
7068:
7066:
7064:
7060:
7054:
7051:
7049:
7046:
7042:
7039:
7037:
7034:
7032:
7029:
7027:
7024:
7022:
7019:
7017:
7014:
7012:
7009:
7007:
7004:
7003:
7002:
6999:
6997:
6994:
6990:
6987:
6985:
6982:
6980:
6977:
6975:
6972:
6971:
6970:
6967:
6963:
6960:
6958:
6955:
6953:
6950:
6948:
6945:
6944:
6943:
6940:
6938:
6935:
6931:
6928:
6926:
6923:
6921:
6918:
6917:
6916:
6913:
6911:
6908:
6904:
6901:
6899:
6896:
6894:
6891:
6890:
6889:
6886:
6885:
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2574:
2570:
2563:
2560:
2555:
2551:
2547:
2543:
2538:
2533:
2529:
2525:
2521:
2517:
2513:
2509:
2505:
2498:
2495:
2490:
2486:
2481:
2476:
2472:
2468:
2464:
2460:
2456:
2449:
2446:
2441:
2437:
2432:
2427:
2423:
2419:
2415:
2408:
2405:
2396:
2388:
2381:
2377:
2373:
2369:
2362:
2358:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2321:
2318:
2313:
2309:
2304:
2299:
2295:
2291:
2287:
2283:
2279:
2272:
2269:
2264:
2260:
2255:
2250:
2246:
2242:
2238:
2234:
2230:
2223:
2220:
2215:
2211:
2206:
2201:
2197:
2193:
2189:
2185:
2181:
2174:
2171:
2166:
2162:
2158:
2154:
2149:
2144:
2140:
2136:
2132:
2125:
2122:
2117:
2113:
2108:
2103:
2098:
2093:
2089:
2085:
2082:(5): e37055.
2081:
2077:
2073:
2066:
2063:
2058:
2054:
2049:
2044:
2039:
2034:
2030:
2026:
2022:
2018:
2014:
2007:
2004:
1999:
1995:
1991:
1987:
1982:
1977:
1973:
1969:
1965:
1958:
1955:
1950:
1946:
1941:
1936:
1932:
1928:
1924:
1917:
1915:
1913:
1909:
1904:
1900:
1895:
1890:
1886:
1882:
1878:
1874:
1867:
1865:
1861:
1856:
1852:
1847:
1842:
1838:
1834:
1830:
1823:
1821:
1819:
1817:
1815:
1813:
1811:
1807:
1802:
1798:
1793:
1788:
1784:
1780:
1776:
1772:
1768:
1761:
1758:
1753:
1749:
1745:
1741:
1736:
1731:
1727:
1723:
1719:
1712:
1710:
1708:
1706:
1704:
1700:
1695:
1691:
1687:
1683:
1678:
1673:
1669:
1665:
1661:
1654:
1651:
1646:
1640:
1636:
1631:
1630:
1621:
1618:
1613:
1609:
1602:
1599:
1594:
1590:
1586:
1582:
1578:
1574:
1570:
1566:
1559:
1556:
1551:
1547:
1543:
1537:
1534:
1529:
1525:
1521:
1517:
1513:
1509:
1505:
1501:
1497:
1493:
1486:
1483:
1478:
1474:
1470:
1466:
1461:
1456:
1452:
1448:
1444:
1440:
1436:
1429:
1427:
1425:
1423:
1421:
1419:
1417:
1415:
1413:
1409:
1404:
1400:
1393:
1390:
1385:
1381:
1376:
1371:
1367:
1363:
1359:
1355:
1351:
1349:
1345:
1336:
1333:
1328:
1324:
1319:
1314:
1310:
1306:
1302:
1298:
1294:
1287:
1284:
1279:
1275:
1270:
1265:
1261:
1257:
1253:
1249:
1245:
1238:
1235:
1230:
1226:
1221:
1216:
1212:
1208:
1204:
1200:
1196:
1189:
1186:
1181:
1177:
1172:
1167:
1163:
1159:
1155:
1151:
1147:
1140:
1137:
1132:
1130:0-306-48330-0
1126:
1122:
1115:
1112:
1107:
1103:
1098:
1093:
1089:
1085:
1081:
1077:
1073:
1066:
1063:
1058:
1054:
1050:
1046:
1042:
1038:
1031:
1029:
1027:
1023:
1017:
1015:
1008:
1006:
1004:
1000:
992:
990:
988:
980:
975:
973:
971:
967:
962:
954:
952:
950:
946:
942:
938:
929:
927:
923:
921:
915:
913:
908:
905:
899:
891:
889:
887:
883:
879:
876:Ngn2 has two
874:
872:
868:
864:
856:
854:
852:
844:
842:
836:
834:
832:
828:
827:motor neurons
820:
818:
816:
812:
808:
800:
798:
796:
789:
781:
779:
772:
770:
767:
763:
759:
755:
754:notch pathway
747:
745:
739:
737:
735:
730:
722:
720:
718:
717:transcription
715:
711:
707:
699:
697:
695:
691:
688:
684:
680:
676:
672:
665:
663:
661:
657:
653:
649:
645:
641:
637:
629:
627:
625:
624:determination
621:
617:
613:
609:
605:
601:
598:
594:
590:
586:
580:
572:
570:
568:
564:
556:
554:
552:
544:
542:
540:
536:
532:
527:
525:
521:
517:
513:
509:
501:
499:
497:
493:
489:
485:
481:
476:
473:
469:
465:
453:
450:
446:
443:
440:
436:
431:
427:
424:
423:
419:
416:
414:
410:
405:
402:
399:
397:
393:
390:
387:
385:
381:
378:
375:
373:
369:
366:
363:
361:
357:
354:
351:
349:
345:
342:
339:
335:
330:
327:
323:
312:
309:
305:
302:
299:
295:
290:
286:
283:
282:
278:
275:
273:
269:
264:
261:
258:
256:
252:
249:
246:
244:
240:
237:
234:
232:
228:
225:
222:
220:
216:
213:
210:
208:
204:
201:
198:
194:
189:
186:
182:
171:
168:
164:
161:
158:
154:
149:
145:
142:
141:
137:
134:
132:
128:
123:
120:
117:
115:
111:
108:
105:
103:
99:
96:
93:
91:
87:
84:
81:
79:
75:
72:
69:
67:
63:
59:
55:
52:
49:
45:
40:
37:
33:
30:
19:
8043:
7998:
7954:
7912:
7904:
7876:
7870:
7864:
7833:
7798:
7786:
7723:
7700:
7682:
7650:
7621:
7502:
7432:
7406:
7358:
7261:
7208:
7128:
7116:
7070:
7062:
6968:
6914:
6887:
6879:
6850:
6839:
6583:FOX proteins
6543:winged helix
6535:
6506:
6489:
6432:
6352:
6326:
6204:
6170:
6153:
6131:
6114:
6047:
6015:
5869:
5832:
5813:
5759:
5725:
5719:
5413:
5407:
5396:
5390:Antennapedia
5388:
5375:
5363:
5357:
5326:
5284:
5262:
5239:
5218:
4976:
4929:
4875:
4821:
4734:
4712:
4690:
4668:
4651:
4609:
4538:
4420:
4388:
4340:
4312:
4292:
4267:
4230:
4196:Progesterone
4149:
4045:
3893:
3879:
3873:
3857:
3799:
3752:
3744:
3642:
3552:
3501:
3459:
3419:
3392:
3362:
3335:
3169:
3159:
3142:
3125:
3103:
3037:
2993:
2961:
2924:
2781:
2671:
2659:
2576:
2572:
2562:
2511:
2507:
2497:
2462:
2458:
2448:
2421:
2417:
2407:
2393:{{
2385:{{
2337:(1): 76–83.
2334:
2330:
2320:
2285:
2281:
2271:
2236:
2232:
2222:
2187:
2183:
2173:
2138:
2134:
2124:
2079:
2075:
2065:
2020:
2016:
2006:
1971:
1967:
1957:
1930:
1926:
1876:
1836:
1832:
1777:(1): 65–77.
1774:
1770:
1760:
1725:
1721:
1667:
1663:
1653:
1628:
1620:
1601:
1568:
1564:
1558:
1545:
1536:
1495:
1491:
1485:
1442:
1438:
1392:
1357:
1353:
1347:
1343:
1335:
1300:
1296:
1286:
1251:
1247:
1237:
1202:
1198:
1188:
1153:
1149:
1139:
1120:
1114:
1082:(1): 14–34.
1079:
1075:
1065:
1040:
1036:
1012:
996:
984:
958:
933:
924:
916:
901:
898:Neurogenin-3
892:Neurogenin-3
875:
860:
848:
840:
831:interneurons
829:and ventral
824:
804:
791:
788:Neurogenin-2
782:Neurogenin-2
776:
762:neural crest
751:
743:
726:
703:
669:
652:enhancer box
633:
608:neurogenesis
582:
579:Neurogenin-1
573:Neurogenin-1
560:
548:
535:neurogenesis
531:neural crest
528:
516:neurogenesis
505:
483:
467:
463:
462:
420:
326:neurogenin 3
279:
185:neurogenin 2
138:
57:Alt. symbols
36:neurogenin 1
29:
7724:(4.11) Runt
5379:Homeodomain
4977:zinc finger
4313:subfamily 0
4293:subfamily 6
4268:subfamily 5
4231:subfamily 4
4150:subfamily 3
4046:subfamily 2
3894:subfamily 1
3861:Zinc finger
3104:Neurogenins
2672:(1.1) Basic
2190:(3): e523.
734:gliogenesis
694:homeodomain
464:Neurogenins
442:Swiss-model
332:Identifiers
301:Swiss-model
191:Identifiers
160:Swiss-model
42:Identifiers
8060:Categories
6257:POU domain
5397:ANTP class
5327:(2.6) WRKY
4610:GLI family
3745:(1.5) RF-X
3643:(1.4) NF-1
1728:(1): 3–5.
1254:(7): 527.
1018:References
683:endogenous
679:stem cells
614:, it must
524:peripheral
488:Drosophila
438:Structures
433:Search for
407:Other data
297:Structures
292:Search for
266:Other data
156:Structures
151:Search for
125:Other data
18:Neurogenin
8044:see also
7885:Apetala 2
6539:Fork head
5219:(2.4) Cys
4421:(2.3) Cys
3153:Scleraxis
2554:205214877
2395:retracted
2387:retracted
904:endocrine
758:zebrafish
690:forebrain
687:embryonic
389:NM_020999
348:NCBI gene
248:NM_024019
207:NCBI gene
107:NM_006161
66:NCBI gene
7362:MADS box
5502:Homeobox
5414:Hox-like
5408:protoHOX
4169:Estrogen
4164:Androgen
4018:Rev-ErbA
3556:bHLH-ZIP
3531:bHLH-COE
3070:Myogenin
2603:25105579
2546:18754011
2489:25476775
2440:16514419
2380:32066957
2361:24240391
2312:20663919
2263:22828498
2214:23470530
2157:18243096
2116:22606327
2076:PLOS ONE
2057:26288179
2017:PLOS ONE
1990:21824252
1949:15256770
1903:21824251
1855:21099270
1801:18400164
1752:13530075
1744:18400155
1686:11572771
1593:10863124
1585:14523379
1550:Archived
1520:21068830
1477:15885798
1469:11369245
1384:32273286
1327:19789989
1278:32661334
1229:21412988
1180:10398684
1106:34971564
970:TATA box
920:diabetes
912:glucagon
907:pancreas
886:alanines
656:promoter
616:dimerize
597:enhancer
502:Function
486:gene in
452:InterPro
311:InterPro
170:InterPro
7762:RUNX1T1
7742:CBFA2T3
7737:CBFA2T2
7617:TCF/LEF
5726:NK-like
5720:metaHOX
5423:ParaHox
5364:domains
4055:COUP-TF
3529:Group F
3452:Group E
3385:Group D
3249:Group C
3199:Group B
3143:Paraxis
3008:Group A
2594:4136739
2537:9011918
2516:Bibcode
2480:4572860
2352:4096987
2303:2915881
2254:3464647
2205:3613830
2165:8058714
2107:3351393
2084:Bibcode
2048:4545947
2025:Bibcode
1894:3467197
1792:2587148
1694:2624758
1612:UniProt
1500:Bibcode
1447:Bibcode
1403:UniProt
1375:7263688
1318:2780551
1269:7359305
1220:3134120
1097:8758946
1057:9570134
945:δ cells
941:β cells
878:serines
863:islet 1
620:protein
587:(bHLH)
520:central
512:neurons
448:Domains
418:Chr. 10
396:UniProt
341:NEUROG3
307:Domains
255:UniProt
200:NEUROG2
166:Domains
140:q23-q31
114:UniProt
60:NEUROD3
51:NEUROG1
6475:Bicoid
5740:BARHL2
5735:BARHL1
5317:JMJD1B
5230:HIVEP1
3715:I-SMAD
3683:R-SMAD
3601:MLXIPL
3356:Period
3282:ARNTL2
3087:NeuroD
2601:
2591:
2552:
2544:
2534:
2508:Nature
2487:
2477:
2438:
2378:
2374:,
2359:
2349:
2310:
2300:
2261:
2251:
2212:
2202:
2163:
2155:
2114:
2104:
2055:
2045:
1998:691004
1996:
1988:
1947:
1901:
1891:
1853:
1833:Islets
1799:
1789:
1771:Neuron
1750:
1742:
1722:Neuron
1692:
1684:
1641:
1608:Q9H2A3
1591:
1583:
1528:573477
1526:
1518:
1492:Nature
1475:
1467:
1399:Q92886
1382:
1372:
1325:
1315:
1276:
1266:
1227:
1217:
1178:
1171:316844
1168:
1127:
1104:
1094:
1055:
1009:Nkx2.2
981:NeuroD
937:α cell
811:Nkx2.2
660:NeuroD
492:NeuroD
484:atonal
401:Q9Y4Z2
384:RefSeq
377:604882
337:Symbol
277:Chr. 4
260:Q9H2A3
243:RefSeq
236:606624
196:Symbol
136:Chr. 5
119:Q92886
102:RefSeq
95:601726
47:Symbol
8025:Sigma
7890:EREBP
7874:EREBP
7865:(0.5)
7834:(0.3)
7757:RUNX3
7752:RUNX2
7747:RUNX1
7691:TFCP2
7612:SSRP1
7433:(4.7)
7423:TBPL1
7407:(4.6)
7359:(4.4)
7209:(4.2)
7150:NFKB2
7145:NFKB1
7140:NF-κB
7129:(4.1)
7053:MYBL2
6840:(3.4)
6536:(3.3)
6485:BICD2
6460:SHOX2
6428:PROP1
6412:PRRX
6322:SATB2
6267:BRN-3
6262:PIT-1
6154:PKNOX
6069:TALE
6065:NOBOX
6038:HESX1
6011:CUTL1
5993:other
5887:NANOG
5750:BARX2
5745:BARX1
5497:MEOX2
5492:MEOX1
5376:(3.1)
5285:JARID
5258:GRLF1
5253:DIDO1
4913:Zbtb7
4903:TSHZ3
4871:PRDM9
4669:HIVEP
4534:ATBF1
4488:TFIIH
4473:TFIIF
4456:TFIIE
4451:TFIID
4446:TFIIB
4441:TFIIA
4411:TRPS1
4277:LRH-1
4255:NURR1
4245:NGFIB
4073:Ear-2
3874:(2.1)
3616:SREBP
3553:(1.3)
3315:NPAS
3304:EPAS1
3289:CLOCK
3277:ARNTL
3251:bHLH-
3227:n-Myc
3222:l-Myc
3217:c-Myc
3207:FIGLA
3189:Twist
3148:TCF15
3055:MESP2
3033:ATOH1
3026:ASCL2
3021:ASCL1
2952:NFIL3
2883:GABPA
2878:DDIT3
2809:C/EBP
2804:BLZF1
2765:c-Jun
2755:FOSL2
2750:FOSL1
2740:c-Fos
2550:S2CID
2391:with
2161:S2CID
1994:S2CID
1748:S2CID
1690:S2CID
1589:S2CID
1524:S2CID
1473:S2CID
1344:ngn-1
1003:HNF1α
961:Delta
815:Olig2
795:dimer
729:glial
648:Smad1
604:genes
496:ASCL1
422:q21.3
413:Locus
365:13806
353:50674
272:Locus
224:13805
212:63973
131:Locus
7994:MNDA
7913:ARID
7868:AP-2
7855:RBL2
7850:RBL1
7824:HBP1
7807:HMGA
7714:YBX1
7709:CSDA
7644:LEF1
7476:HMGN
7449:HMGB
7370:Mef2
7349:MYRF
7337:TBR2
7332:TBR1
7280:TP63
7220:STAT
7212:STAT
7172:NFAT
7165:RELB
7160:RELA
7115:(4)
6996:FLI1
6962:SPIB
6663:D4L6
6658:D4L5
6653:D4L4
6648:D4L3
6643:D4L1
6507:PITX
6470:VSX2
6465:VSX1
6455:SHOX
6433:PHOX
6115:MEIS
6043:HOPX
5979:VAX2
5974:VAX1
5969:TLX3
5964:TLX2
5959:TLX1
5954:NATO
5937:HMX3
5932:HMX2
5927:HMX1
5865:LBX2
5860:LBX1
5850:HHEX
5709:MNX1
5704:GBX2
5699:GBX1
5487:Evx2
5482:Evx1
5450:PDX1
5445:Xlox
5335:WRKY
5248:AIRE
5207:804A
4930:ZBTB
4876:SALL
4866:OSR1
4861:MYT1
4856:MTF1
4691:IKZF
4630:REST
4605:GFI1
4600:ERV3
4568:E4F1
4563:CTCF
4352:GATA
4322:DAX1
4302:GCNF
4250:NOR1
4078:HNF4
3947:PPAR
3880:(Cys
3808:AP-2
3678:SMAD
3633:USF1
3606:MXI1
3586:MITF
3579:MXD3
3574:MXD1
3564:AP-4
3539:EBF1
3415:Pho4
3393:BHLH
3272:ARNT
3267:AHRR
3239:TCF4
3234:MXD4
3165:LYL1
3126:OLIG
3080:MYF6
3075:MYF5
3065:MyoD
3038:HAND
3016:AS-C
2998:bHLH
2984:XBP1
2888:GCN4
2868:CREM
2846:CREB
2799:BATF
2782:BACH
2775:JunD
2770:JUNB
2760:JDP2
2745:FOSB
2735:AP-1
2693:AATF
2679:bZIP
2645:and
2599:PMID
2542:PMID
2485:PMID
2436:PMID
2376:PMID
2357:PMID
2308:PMID
2259:PMID
2210:PMID
2153:PMID
2135:Cell
2112:PMID
2053:PMID
1986:PMID
1945:PMID
1899:PMID
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