815:. In 2013, FDA warned the public that Potiga (ezogabine) can cause blue skin discoloration and eye abnormalities characterized by pigment changes in the retina. FDA does not currently know if these changes are reversible. FDA is working with the manufacturer to gather and evaluate all available information to better understand these events. FDA will update the public when more information is available. Psychiatric symptoms and difficulty urinating have also been reported, with most cases occurring in the first 2 months of treatment.
558:
535:
29:
8524:
1074:—a program sponsored by the American Medical Association, the United States Pharmacopeial Convention, and the American Pharmacists Association that chooses nonproprietary names for drug sold in the United States—adopted the same name. In 2010, however, the USAN Council rescinded its previous decision and assigned "ezogabine" as the
889:
The term "channel opener" refers to a shift in the voltage dependence for channel opening towards more negative potentials. This means that KCNQ/Kv7 channels open at more negative potentials in the presence of
Retigabine. Recently, it has also been shown that Retigabine stabilizes the open Kv7.2/7.3
1030:
as an adverse effect was considered a significant concern, and the panel's members recommended that some sort of monitoring strategy be used to identify patients at risk of bladder dysfunction. Potiga was approved by the FDA on June 10, 2010, but did not become available on the U.S. market until it
1025:
for retigabine on
December 30, 2009. The FDA Peripheral and Central Nervous System Drugs Advisory Committee met on August 11, 2010, to discuss the process and unanimously recommended approval of Potiga for the intended indication (add-on treatment of partial seizures in adults). However, the
997:
reduced (by 23 to 35%) in participants receiving retigabine, and approximately one fourth to one third of participants had their seizure frequency reduced by more than 50%. Higher doses were associated with a greater response to treatment.
890:
channel, making deactivation slower with little change in voltage dependence. This effect of
Retigabine is observed at concentrations below 10 micromolar. A similar effect is observed on the homomeric Kv7.2 channel.
992:
clinical trial, retigabine was added to the treatment regimen of 399 participants with partial seizures that were refractory to therapy with other antiepileptic drugs. The frequency with which seizures occurred was
945:
setting: it was the subject of over 100 published studies before clinical trials began. In preclinical tests, it was found to have a very broad spectrum of activity—being effective in nearly all the
5901:
206:
5869:
5820:
1095:
Ferron GM, Paul J, Fruncillo R, Richards L, Knebel N, Getsy J, Troy S (February 2002). "Multiple-dose, linear, dose-proportional pharmacokinetics of retigabine in healthy volunteers".
4585:
4430:
136:
8564:
161:
1810:
5637:
8502:
6056:
5894:
2817:
898:
Retigabine is quickly absorbed, and reaches maximum plasma concentrations between half an hour and 2 hours after a single oral dose. It has a moderately high oral
68:
5910:
1233:
Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine".
644:
5887:
882:, a mechanism of action markedly different from that of any current anticonvulsants. This mechanism of action is similar to that of the chemically similar
1435:
Porter RJ, Partiot A, Sachdeo R, Nohria V, Alves WM (April 2007). "Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures".
2126:
119:
8250:
783:
found in the Phase II trial mainly affected the central nervous system, and appeared to be dose-related. The most common adverse effects were
5806:
4296:
2761:
1935:
1811:"Valeant Pharmaceuticals Announces Preliminary Results From Its Phase IIa Retigabine Study for the Treatment of Postherpetic Neuralgia (PHN)"
4736:
4714:
2810:
1996:
1478:
4609:
8554:
5538:
2843:
8559:
8498:
7929:
3464:
1059:
691:
664:
132:
630:
3808:
4499:
4319:
2803:
1043:
1036:
876:
872:
752:
328:
191:
100:
1195:
Rundfeldt C (October 1997). "The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells".
1162:
7449:
5066:
4796:
2119:
8514:
1050:(CSA), the category for substances with a comparatively low potential for abuse. This became effective 15 December 2011.
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7182:
5865:
2648:
2003:
1975:
1885:
1483:
737:
454:
8150:
7100:
1174:
8218:
7329:
5845:
2778:
2309:
986:
759:
is unique among antiepileptic drugs, and may hold promise for the treatment of other neurologic conditions, including
514:
1561:
Luszczki JJ (2009). "Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions".
672:
InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
7339:
1075:
699:
55:
7354:
7349:
7344:
5831:
5405:
4728:
4626:
4310:
3822:
1931:
1063:
1047:
1032:
726:
232:
114:
7212:
8569:
8544:
7911:
7907:
7080:
5733:
5651:
5552:
5469:
5338:
4761:
4658:
4490:
4259:
2619:
2112:
994:
942:
879:
748:
403:
7227:
7217:
5679:
5615:
4951:
2857:
2766:
2528:
2486:
2365:
933:
system is not involved. Retigabine and its metabolites are excreted almost completely (84%) by the kidneys.
718:
147:
553:
6096:
5483:
5419:
4810:
3776:
3767:
3331:
3318:
3300:
3242:
2866:
2657:
2395:
2080:
1078:
for the drug. The drug will thus be known as "ezogabine" in the United States and "retigabine" elsewhere.
1006:
903:
260:
7202:
7187:
1281:"New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels"
8574:
8441:
8119:
7172:
7167:
7162:
5702:
5697:
5687:
5447:
5348:
2355:
780:
503:
394:
7207:
6849:
4926:
3381:
2434:
3252:
1882:"August 11, 2010: Peripheral and Central Nervous System Drugs Advisory Committee Meeting Announcement"
8236:
8223:
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1138:
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907:
840:
294:
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530:
8549:
8349:
8232:
7359:
7285:
6374:
6216:
5924:
5692:
3830:
3376:
3234:
2188:
756:
349:
154:
5771:
4392:
3137:
3082:
3077:
3042:
1950:
949:
of seizures and epilepsy used: retigabine suppresses seizures induced by electroshock, electrical
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7989:
7887:
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7177:
6549:
6151:
5253:
5016:
4946:
4102:
4097:
4000:
3875:
3732:
3707:
3607:
3477:
3351:
3199:
3162:
3062:
3057:
2957:
2942:
2937:
2902:
1906:
1586:
1460:
1414:
1258:
1120:
4572:
3995:
3970:
3885:
3532:
3522:
3112:
3102:
3072:
3067:
3032:
2987:
2932:
2922:
2917:
1968:
1881:
8453:
7275:
5932:
5455:
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4557:
4542:
4512:
3930:
3840:
3272:
3177:
3167:
3147:
3127:
3107:
2007:
1936:"International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 76"
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8240:
8183:
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8155:
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7892:
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5362:
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5228:
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4532:
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3446:
3229:
2826:
2469:
2384:
2333:
2279:
2092:
2079:
Hempel R, Schupke H, McNeilly PJ, Heinecke K, Kronbach C, Grunwald C, et al. (May 1999).
2067:
1792:
1743:
1684:
1635:
1578:
1452:
1406:
1366:
1310:
1250:
1212:
1112:
1027:
1010:
958:
219:
41:
7630:
7090:
3980:
3960:
3356:
3336:
1535:
973:. Researchers hoped this wide-ranging activity would translate to studies in humans as well.
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7811:
7298:
7075:
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6977:
6884:
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6434:
6326:
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5026:
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4741:
4595:
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4249:
4244:
3587:
3341:
2439:
2057:
2049:
1782:
1774:
1733:
1723:
1674:
1666:
1625:
1617:
1570:
1444:
1398:
1356:
1348:
1300:
1292:
1242:
1204:
1104:
824:
768:
714:
570:
443:
358:
242:
5511:
463:
8528:
8437:
8302:
8286:
8274:
8228:
8179:
7994:
7969:
7964:
7778:
7511:
7364:
6166:
6161:
6023:
5956:
5781:
5776:
5746:
5575:
5570:
5173:
5138:
5128:
5093:
4700:
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4142:
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3287:
2872:
2834:
1163:
https://assets.publishing.service.gov.uk/media/57fe4b6640f0b6713800000c/Trobalt_letter.pdf
930:
922:
914:
899:
722:
707:
286:
278:
270:
250:
557:
534:
1653:
Corbin-Leftwich A, Mossadeq SM, Ha J, Ruchala I, Le AH, Villalba-Galea CA (March 2016).
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1336:
1305:
1280:
1002:
989:
950:
855:
703:
1574:
1208:
941:
Among the newer anticonvulsants, retigabine was one of the most widely studied in the
910:
of 8 to 11 hours. Retigabine requires thrice-daily dosing due to its short half-life.
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8408:
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8203:
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2738:
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2552:
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2481:
2198:
2193:
2036:
Blackburn-Munro G, Dalby-Brown W, Mirza NR, Mikkelsen JD, Blackburn-Munro RE (2005).
1778:
1621:
1402:
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92:
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5298:
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5198:
5133:
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4841:
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4397:
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3702:
3682:
3622:
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2708:
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2414:
2178:
2139:
1831:
1124:
1071:
982:
946:
383:
174:
169:
1070:
International
Nonproprietary Name (rINN) for the drug, and, in 2005 or 2006, the
8464:
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8029:
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2238:
2183:
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86:
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inhibitor, and may thus increase absorption and reduce elimination of digoxin.
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28:
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2594:
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2404:
2370:
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2289:
2268:
2253:
2248:
2218:
2208:
2203:
2148:
1969:"Statement on a nonproprietary name adopted by the USAN council: Retigabine"
1907:"Schedules of Controlled Substances: Placement of Ezogabine Into Schedule V"
832:
788:
307:
72:
5638:
2096:
2071:
1997:"Statement on a nonproprietary name adopted by the USAN council: Ezogabine"
1796:
1747:
1688:
1639:
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1456:
1410:
1370:
1314:
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1116:
78:
20:
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1216:
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3391:
3182:
3142:
3122:
2795:
2698:
2672:
2429:
2409:
2243:
2228:
1860:
1655:"Retigabine holds KV7 channels open and stabilizes the resting potential"
1506:
1246:
1005:
trial meant to assess the safety and efficacy of retigabine for treating
954:
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7650:
7635:
7516:
7255:
7115:
6569:
6276:
5977:
5501:
5323:
5123:
4648:
4047:
3985:
3647:
3627:
3323:
3194:
2275:
1763:"Diverse mechanisms of antiepileptic drugs in the development pipeline"
847:
827:
with most commonly used anticonvulsants. It may increase metabolism of
796:
369:
8359:
8322:
7944:
7897:
7768:
7750:
7710:
7394:
7192:
5327:
4440:
4112:
4032:
3915:
3905:
3687:
3456:
1062:"retigabine" was initially published as being under consideration by
804:
494:
312:
483:
7720:
4067:
3920:
1857:"Epilepsy drug exogabine gets green light from FDA Advisory Panel"
1013:. Preliminary results were reported by Valeant as "inconclusive".
771:. The manufacturer withdrew retigabine from clinical use in 2017.
629:
620:
275:
854:
studies suggest that the main metabolite of retigabine acts as a
7153:
5565:
4268:
4230:
4013:
1389:
Plosker GL, Scott LJ (2006). "Retigabine: in partial seizures".
966:
808:
474:
213:
109:
5883:
4591:
Tooltip G protein-coupled inwardly rectifying potassium channel
4436:
Tooltip G protein-coupled inwardly rectifying potassium channel
2799:
2108:
226:
126:
118:
1139:"POTIGA (ezogabine) Tablets, CV. Full Prescribing Information"
744:, on June 10, 2011. Production was discontinued in June 2017.
5807:
4297:
4715:
2081:"Metabolism of retigabine (D-23129), a novel anticonvulsant"
519:
5643:
Tooltip Cystic fibrosis transmembrane conductance regulator
4610:
200:
5539:
2844:
1905:
U.S. Drug
Enforcement Administration (15 December 2011).
1021:
16:
Anticonvulsant, which works as a potassium-channel opener
3809:
2038:"Retigabine: chemical synthesis to clinical application"
4500:
4320:
1175:"Epilepsy drug Trobalt (retigabine) to be discontinued"
1009:
was completed in 2009, but failed to meet its primary
713:
in treatment-experienced adult patients. The drug was
8512:
4797:
886:, which is used mainly for its analgesic properties.
1536:"Trobalt – Summary of Product Characteristics (SPC)"
8138:
7906:
7843:
7810:
7777:
7749:
7463:
7284:
7241:
7152:
7124:
7036:
6918:
6360:
6047:
5923:
5830:
5805:
5798:
5732:
5725:
5678:
5650:
5636:
5614:
5551:
5537:
5528:
5482:
5468:
5446:
5418:
5404:
5347:
4809:
4795:
4786:
4760:
4727:
4713:
4657:
4625:
4608:
4489:
4309:
4295:
4258:
3821:
3807:
3798:
3766:
2856:
2842:
2833:
2691:
2647:
2640:
2618:
2527:
2394:
2383:
2347:
2308:
2156:
2147:
618:
605:
569:
564:
545:
513:
493:
473:
453:
433:
413:
402:
393:
368:
348:
319:
306:
293:
269:
259:
249:
241:
190:
185:
160:
146:
99:
85:
67:
50:
40:
35:
1046:(DEA) placed the substance into Schedule V of the
8462:Unsorted benzodiazepine site positive modulators:
5832:
5406:
5470:
850:may increase serum concentration of the latter.
382:
5870:Transient receptor potential channel modulators
1503:"FDA approves ezogabine for seizures in adults"
1479:"Potiga (Ezogabine): Drug Safety Communication"
357:
1330:
1328:
1326:
1324:
1274:
1272:
1228:
1226:
131:
8565:GABAA receptor positive allosteric modulators
5895:
5812:Tooltip Transient receptor potential channels
4302:Tooltip Inwardly rectifying potassium channel
2811:
2120:
1538:. electronic Medicines Compendium. 2011-05-05
1190:
1188:
1144:. GlaxoSmithKline and Valeant Pharmaceuticals
8:
4720:Tooltip Tandem pore domain potassium channel
1850:
1848:
751:—that is, by activating a certain family of
19:
5911:
4618:Tooltip Calcium-activated potassium channel
1556:
1554:
1552:
1496:
1494:
5902:
5888:
5880:
5802:
5729:
5647:
5548:
5544:Tooltip Calcium-activated chloride channel
5534:
5479:
5415:
4806:
4792:
4724:
4622:
4306:
3836:4-Aminopyridine (fampridine/dalfampridine)
3818:
3804:
2853:
2849:Tooltip Voltage-dependent calcium channels
2839:
2818:
2804:
2796:
2644:
2391:
2153:
2127:
2113:
2105:
1337:"Retigabine: has the orphan found a home?"
1285:Current Neurology and Neuroscience Reports
556:
533:
442:
2061:
1786:
1737:
1727:
1678:
1629:
1430:
1428:
1384:
1382:
1380:
1360:
1304:
462:
3814:Tooltip Voltage-gated potassium channels
8519:
4508:Tooltip ATP-sensitive potassium channel
4328:Tooltip ATP-sensitive potassium channel
1834:(Press release). PRNewswire. 2009-12-30
1813:(Press release). PRNewswire. 2009-08-24
1087:
1066:in 1996. This was later adopted as the
669:
649:
529:
422:
333:
91:
1530:
1528:
1526:
1524:
1522:
547:
18:
4802:Tooltip Voltage-gated sodium channels
502:
77:
59:
7:
8503:GABA metabolism/transport modulators
4737:12-O-Tetradecanoylphorbol-13-acetate
1832:"Retigabine NDA accepted for filing"
1604:Brown DA, Passmore GM (April 2009).
803:. Less common side effects included
706:used as an adjunctive treatment for
173:
8120:Trichloroethane (methyl chloroform)
3831:3,4-Diaminopyridine (amifampridine)
1279:Rogawski MA, Bazil CW (July 2008).
482:
373:
7183:11-Methoxy-12-hydroxydehydrokavain
2054:10.1111/j.1527-3458.2005.tb00033.x
1708:7 Channel Deactivation by PI(4,5)P
1449:10.1212/01.wnl.0000259034.45049.00
846:Concomitant use of retigabine and
14:
7930:Acetylglycinamide chloral hydrate
5837:Tooltip Ligand gated ion channels
5411:Tooltip Epithelial sodium channel
1659:The Journal of General Physiology
1060:International Nonproprietary Name
823:Retigabine appears to be free of
652:O=C(OCC)Nc1ccc(cc1N)NCc2ccc(F)cc2
302:8 hours (mean), range: 7–11 hours
8522:
5475:Tooltip Acid-sensing ion channel
1779:10.1016/j.eplepsyres.2006.02.004
1702:Villalba-Galea CA (2020-06-19).
1622:10.1111/j.1476-5381.2009.00111.x
1403:10.2165/00023210-200620070-00005
1353:10.1111/j.1535-7511.2007.00209.x
1197:European Journal of Pharmacology
1097:Journal of Clinical Pharmacology
753:voltage-gated potassium channels
747:Retigabine works primarily as a
590:
587:
581:
27:
8350:Menthyl isovalerate (validolum)
2085:Drug Metabolism and Disposition
1610:British Journal of Pharmacology
1397:(7): 601–8, discussion 609–10.
1044:Drug Enforcement Administration
1037:Drug Enforcement Administration
677:Key:PCOBBVZJEWWZFR-UHFFFAOYSA-N
7299:Allopregnanolone (brexanolone)
3293:Ziconotide (ω-conotoxin MVIIA)
987:randomized, placebo-controlled
871:Retigabine acts as a neuronal
733:on March 28, 2011, and by the
596:
575:
1:
8495:Receptor/signaling modulators
7051:Ampelopsin (dihydromyricetin)
5866:Receptor/signaling modulators
3268:Leconotide (ω-conotoxin CVID)
1575:10.1016/s1734-1140(09)70024-6
1209:10.1016/S0014-2999(97)01249-1
839:(CBZ, Tegretol) increase the
8245:ergoloid (dihydroergotoxine)
7330:anabolic-androgenic steroids
6112:Butabarbital/Secbutabarbital
5917:receptor positive modulators
2004:American Medical Association
1976:American Medical Association
1886:Food and Drug Administration
1606:"Neural KCNQ (Kv7) channels"
1484:Food and Drug Administration
740:(FDA), under the trade name
738:Food and Drug Administration
6885:Triflunordazepam (Ro5-2904)
1042:In December 2011, the U.S.
8591:
7213:5,6,7,8-Tetrahydroyangonin
4829:Antiarrhythmics (class I):
1076:United States Adopted Name
565:Chemical and physical data
8555:Potassium channel openers
8488:
7405:Pregnanolone (eltanolone)
5948:Chlorobutanol (cloretone)
5859:
5339:Tricyclic antidepressants
4348:Glibenclamide (glyburide)
2756:
1932:World Health Organization
1761:Rogawski MA (June 2006).
1716:Frontiers in Pharmacology
1297:10.1007/s11910-008-0053-7
1109:10.1177/00912700222011210
1048:Controlled Substances Act
727:European Medicines Agency
725:. It was approved by the
660:
640:
324:
26:
8560:4-Fluorophenyl compounds
8499:GABA receptor modulators
8409:sulfonmethane (sulfonal)
1949:(4): 215. Archived from
1729:10.3389/fphar.2020.00895
880:potassium channel opener
749:potassium channel opener
4952:Eslicarbazepine acetate
2487:Eslicarbazepine acetate
1563:Pharmacological Reports
1335:Ben-Menachem E (2007).
906:(6.2 L/kg), and a
719:Valeant Pharmaceuticals
79:Professional Drug Facts
8385:Retigabine (ezogabine)
7661:Lirequinil (Ro41-3696)
7228:7,8-Dihydromethysticin
7218:5,6-Dehydromethysticin
6097:Benzylbutylbarbiturate
4696:Rottlerin (mallotoxin)
2827:Ion channel modulators
1855:Lowry F (2010-08-12).
1235:Molecular Pharmacology
1179:epilepsysociety.org.uk
1007:postherpetic neuralgia
904:volume of distribution
3053:Ryodipine (riodipine)
1671:10.1085/jgp.201511517
1501:Hitt E (2011-06-13).
729:under the trade name
8440:constituents (e.g.,
8224:Deuterated etifoxine
7286:Neuroactive steroids
7256:Apronal (apronalide)
7108:constituents (e.g.,
6725:N-Desalkylflurazepam
5042:Valproate semisodium
3573:Carboxyamidotriazole
3508:Gabapentin enacarbil
3488:Arbaclofen placarbil
1943:WHO Drug Information
1247:10.1124/mol.58.2.253
1181:. 14 September 2016.
1023:New Drug Application
831:(Lamictal), whereas
54:D-23129, ezogabine (
8233:dihydroergocryptine
7545:Pyrazolopyrimidines
7203:5,6-Dihydroyangonin
7188:7,8-Dihydroyangonin
6375:3-Hydroxyphenazepam
6217:Methylphenobarbital
5693:1,10-Phenanthroline
4250:Spooky toxin (SsTx)
3235:Tetrahydropalmatine
2189:Methylphenobarbital
1017:Regulatory approval
867:Mechanism of action
757:mechanism of action
755:in the brain. This
222:(Prescription only)
209:(Prescription only)
23:
8327:4-O-methylhonokiol
7990:Dichloralphenazone
7888:Methylmethaqualone
7465:Nonbenzodiazepines
7178:Desmethoxyyangonin
7173:11-Hydroxyyangonin
7168:11-Methoxyyangonin
7163:10-Methoxyyangonin
6550:Ethyl carfluzepate
6152:Cyclopentobarbital
5703:7,8-Benzoquinoline
5698:4,7-Phenanthroline
5688:1,7-Phenanthroline
5064:Local anesthetics:
4596:ML-297 (VU0456810)
4103:Diallyl trisulfide
4098:Dextropropoxyphene
4001:Tetraethylammonium
3708:Pinaverium bromide
3478:4-Methylpregabalin
2783:Never to phase III
908:terminal half-life
811:disturbances, and
8510:
8509:
8470:MRK-409 (MK-0343)
8241:dihydroergotamine
8184:potassium bromide
8178:compounds (e.g.,
8125:Trichloroethylene
7893:Nitromethaqualone
7812:Pyrazolopyridines
7314:3α-Androstanediol
7208:7,8-Dihydrokavain
6560:Ethyl loflazepate
6337:Thiotetrabarbital
5953:Ethanol (alcohol)
5877:
5876:
5855:
5854:
5794:
5793:
5790:
5789:
5752:Meclofenamic acid
5721:
5720:
5632:
5631:
5524:
5523:
5520:
5519:
5464:
5463:
5400:
5399:
5274:RG7893 (GDC-0287)
5037:Valproate pivoxil
4927:Acetylpheneturide
4782:
4781:
4778:
4777:
4709:
4708:
4681:Meclofenamic acid
4644:Ethanol (alcohol)
4604:
4603:
4553:Minoxidil sulfate
4291:
4290:
3794:
3793:
3790:
3789:
3693:Otilonium bromide
3618:Ethanol (alcohol)
3382:ω-Conotoxin MVIIC
3118:Phenylalkylamines
2793:
2792:
2752:
2751:
2636:
2635:
2620:Potassium openers
2538:Oxazolidinediones
2470:Valproate pivoxil
2435:Acetylpheneturide
2379:
2378:
2334:Valproate pivoxil
2310:GABA-T inhibitors
2280:potassium bromide
1956:on June 27, 2004.
1767:Epilepsy Research
1443:(15): 1197–1204.
1341:Epilepsy Currents
1028:urinary retention
959:pentylenetetrazol
917:in the liver, by
902:(50–60%), a high
825:drug interactions
799:, confusion, and
685:
684:
631:Interactive image
515:CompTox Dashboard
340:-phenyl]carbamate
230:
217:
204:
129:
112:
62:
8582:
8527:
8526:
8525:
8518:
8229:Dihydroergolines
8146:3-Hydroxybutanal
7779:Piperidinediones
7512:Imidazopyridines
7046:6-Methylapigenin
6978:Hydroxyphenamate
6850:SH-053-R-CH3-2′F
6555:Ethyl dirazepate
6435:Chlordiazepoxide
6327:Thiobutabarbital
6039:Trifluoroethanol
6029:Trichloroethanol
6019:-Pentanol (2M2B)
5913:
5904:
5897:
5890:
5881:
5838:
5834:
5813:
5809:
5803:
5730:
5648:
5644:
5640:
5549:
5545:
5541:
5535:
5480:
5476:
5472:
5416:
5412:
5408:
5027:Sodium valproate
4942:Chlorphenacemide
4924:Anticonvulsants:
4807:
4803:
4799:
4793:
4742:Arachidonic acid
4725:
4721:
4717:
4623:
4619:
4615:
4592:
4588:
4509:
4505:
4461:Dextromethorphan
4437:
4433:
4329:
4325:
4307:
4303:
4299:
3819:
3815:
3811:
3805:
3777:L-type-selective
3588:Dimeditiapramine
3550:Others/unsorted:
3332:T-type-selective
3319:R-type-selective
3301:P-type-selective
3253:ω-Conotoxin GVIA
3243:N-type-selective
2873:Dihydropyridines
2867:L-type-selective
2854:
2850:
2846:
2840:
2820:
2813:
2806:
2797:
2645:
2529:Calcium blockers
2440:Chlorphenacemide
2392:
2366:GAT-1 inhibitors
2154:
2129:
2122:
2115:
2106:
2100:
2075:
2065:
2042:CNS Drug Reviews
2022:
2021:
2019:
2018:
2012:
2006:. Archived from
2001:
1992:
1986:
1985:
1983:
1982:
1973:
1964:
1958:
1957:
1955:
1940:
1928:
1922:
1921:
1914:Federal Register
1911:
1902:
1896:
1895:
1893:
1892:
1877:
1871:
1870:
1868:
1867:
1852:
1843:
1842:
1840:
1839:
1828:
1822:
1821:
1819:
1818:
1807:
1801:
1800:
1790:
1758:
1752:
1751:
1741:
1731:
1704:"Modulation of K
1699:
1693:
1692:
1682:
1650:
1644:
1643:
1633:
1616:(8): 1185–1195.
1601:
1595:
1594:
1558:
1547:
1546:
1544:
1543:
1532:
1517:
1516:
1514:
1513:
1498:
1489:
1488:
1475:
1469:
1468:
1432:
1423:
1422:
1386:
1375:
1374:
1364:
1332:
1319:
1318:
1308:
1276:
1267:
1266:
1230:
1221:
1220:
1203:(2–3): 243–249.
1192:
1183:
1182:
1171:
1165:
1160:
1154:
1153:
1151:
1149:
1143:
1135:
1129:
1128:
1092:
894:Pharmacokinetics
769:neuropathic pain
633:
613:
598:
592:
589:
583:
577:
560:
549:
538:
537:
523:
521:
506:
486:
466:
446:
426:
406:
386:
376:
375:
361:
298:
228:
225:
215:
212:
202:
199:
177:
139:
128:
125:
122:
111:
108:
95:
81:
61:
58:
31:
24:
22:
8590:
8589:
8585:
8584:
8583:
8581:
8580:
8579:
8570:Withdrawn drugs
8545:Anticonvulsants
8535:
8534:
8533:
8523:
8521:
8513:
8511:
8506:
8484:
8442:isovaleric acid
8405:Sulfonylalkanes
8303:Hopantenic acid
8287:tolfenamic acid
8275:flufenamic acid
8237:dihydroergosine
8180:lithium bromide
8139:Others/unsorted
8134:
7995:Dichloromethane
7970:Chloral hydrate
7965:Chloral betaine
7902:
7839:
7806:
7773:
7745:
7474:Cyclopyrrolones
7459:
7365:Etiocholanolone
7280:
7237:
7198:5-Hydroxykavain
7148:
7120:
7032:
6914:
6362:Benzodiazepines
6356:
6167:Ethallobarbital
6162:Enallylpropymal
6043:
6024:Tribromoethanol
6011:-Butanol (2M2P)
5957:alcoholic drink
5919:
5916:
5908:
5878:
5873:
5851:
5836:
5826:
5811:
5786:
5782:Trifluoperazine
5777:Tolfenamic acid
5747:Flufenamic acid
5717:
5674:
5642:
5628:
5610:
5576:Flufenamic acid
5571:Ethacrynic acid
5543:
5516:
5474:
5460:
5442:
5410:
5396:
5343:
5174:Metabutoxycaine
5139:Diphenhydramine
5129:Cyclomethycaine
5094:Levobupivacaine
4801:
4774:
4756:
4719:
4705:
4701:Tolfenamic acid
4676:Flufenamic acid
4671:
4653:
4639:
4617:
4614:
4600:
4590:
4507:
4504:
4485:
4435:
4327:
4324:
4301:
4287:
4272:
4254:
4234:
4143:Norpropoxyphene
4020:11.1)-specific:
4019:
3813:
3786:
3762:
3718:Rhynchophylline
3468:
2848:
2829:
2824:
2794:
2789:
2788:
2773:Clinical trials
2748:
2687:
2632:
2614:
2523:
2396:Sodium blockers
2386:
2375:
2343:
2304:
2224:Benzodiazepines
2161:
2143:
2136:Anticonvulsants
2133:
2103:
2078:
2035:
2031:
2029:Further reading
2026:
2025:
2016:
2014:
2010:
1999:
1994:
1993:
1989:
1980:
1978:
1971:
1966:
1965:
1961:
1953:
1938:
1930:
1929:
1925:
1909:
1904:
1903:
1899:
1890:
1888:
1879:
1878:
1874:
1865:
1863:
1854:
1853:
1846:
1837:
1835:
1830:
1829:
1825:
1816:
1814:
1809:
1808:
1804:
1760:
1759:
1755:
1711:
1707:
1701:
1700:
1696:
1652:
1651:
1647:
1603:
1602:
1598:
1560:
1559:
1550:
1541:
1539:
1534:
1533:
1520:
1511:
1509:
1500:
1499:
1492:
1477:
1476:
1472:
1434:
1433:
1426:
1388:
1387:
1378:
1334:
1333:
1322:
1278:
1277:
1270:
1232:
1231:
1224:
1194:
1193:
1186:
1173:
1172:
1168:
1161:
1157:
1147:
1145:
1141:
1137:
1136:
1132:
1094:
1093:
1089:
1084:
1056:
1026:possibility of
1019:
979:
977:Clinical trials
939:
931:cytochrome P450
923:glucuronidation
900:bioavailability
896:
869:
864:
843:of retigabine.
835:(Dilantin) and
821:
807:, memory loss,
781:adverse effects
777:
775:Adverse effects
723:GlaxoSmithKline
681:
678:
673:
668:
667:
656:
653:
648:
647:
636:
611:
601:
595:
586:
580:
541:
517:
509:
489:
469:
449:
429:
409:
389:
372:
364:
344:
341:
332:
331:
296:
279:glucuronidation
261:Protein binding
251:Bioavailability
243:Pharmacokinetic
237:
181:
149:
142:
46:Trobalt, Potiga
17:
12:
11:
5:
8588:
8586:
8578:
8577:
8572:
8567:
8562:
8557:
8552:
8547:
8537:
8536:
8532:
8531:
8508:
8507:
8489:
8486:
8485:
8483:
8482:
8477:
8472:
8467:
8458:
8457:
8450:valerenic acid
8435:
8430:
8420:
8402:
8397:
8392:
8387:
8382:
8377:
8372:
8367:
8362:
8357:
8352:
8347:
8342:
8320:
8315:
8310:
8305:
8300:
8295:
8290:
8279:mefenamic acid
8268:
8263:
8258:
8253:
8248:
8226:
8221:
8216:
8211:
8206:
8201:
8196:
8191:
8188:sodium bromide
8173:
8163:
8158:
8153:
8148:
8142:
8140:
8136:
8135:
8133:
8132:
8127:
8122:
8117:
8112:
8107:
8102:
8097:
8092:
8087:
8082:
8077:
8072:
8067:
8062:
8057:
8055:Methoxypropane
8052:
8050:Methoxyflurane
8047:
8042:
8037:
8032:
8027:
8022:
8017:
8012:
8010:Ethyl chloride
8007:
8002:
7997:
7992:
7987:
7982:
7977:
7972:
7967:
7962:
7957:
7952:
7947:
7942:
7937:
7932:
7927:
7922:
7916:
7914:
7904:
7903:
7901:
7900:
7895:
7890:
7885:
7880:
7875:
7870:
7865:
7860:
7855:
7849:
7847:
7845:Quinazolinones
7841:
7840:
7838:
7837:
7832:
7827:
7822:
7816:
7814:
7808:
7807:
7805:
7804:
7799:
7794:
7789:
7783:
7781:
7775:
7774:
7772:
7771:
7766:
7761:
7755:
7753:
7747:
7746:
7744:
7743:
7738:
7733:
7728:
7723:
7718:
7713:
7708:
7703:
7698:
7693:
7688:
7683:
7678:
7673:
7668:
7663:
7658:
7653:
7648:
7643:
7638:
7633:
7628:
7623:
7618:
7613:
7608:
7603:
7598:
7588:
7587:
7582:
7577:
7572:
7567:
7562:
7557:
7552:
7540:
7539:
7534:
7529:
7524:
7519:
7507:
7506:
7501:
7496:
7491:
7486:
7481:
7469:
7467:
7461:
7460:
7458:
7457:
7452:
7447:
7442:
7437:
7432:
7427:
7422:
7417:
7412:
7407:
7402:
7397:
7392:
7387:
7382:
7377:
7372:
7367:
7362:
7357:
7352:
7347:
7342:
7337:
7332:
7326:
7321:
7316:
7311:
7306:
7301:
7296:
7290:
7288:
7282:
7281:
7279:
7278:
7273:
7268:
7263:
7258:
7253:
7247:
7245:
7239:
7238:
7236:
7235:
7230:
7225:
7220:
7215:
7210:
7205:
7200:
7195:
7190:
7185:
7180:
7175:
7170:
7165:
7159:
7157:
7150:
7149:
7147:
7146:
7141:
7136:
7130:
7128:
7122:
7121:
7119:
7118:
7113:
7103:
7098:
7093:
7088:
7083:
7078:
7073:
7068:
7063:
7058:
7053:
7048:
7042:
7040:
7034:
7033:
7031:
7030:
7025:
7020:
7015:
7010:
7005:
7000:
6995:
6990:
6985:
6980:
6975:
6970:
6965:
6960:
6955:
6950:
6945:
6940:
6935:
6930:
6924:
6922:
6916:
6915:
6913:
6912:
6907:
6902:
6897:
6892:
6887:
6882:
6877:
6872:
6867:
6862:
6857:
6852:
6847:
6842:
6837:
6832:
6827:
6822:
6817:
6812:
6807:
6802:
6797:
6792:
6787:
6782:
6777:
6772:
6767:
6762:
6757:
6752:
6747:
6742:
6737:
6732:
6727:
6722:
6717:
6712:
6707:
6702:
6697:
6692:
6687:
6682:
6677:
6672:
6667:
6662:
6657:
6652:
6647:
6642:
6637:
6632:
6627:
6622:
6617:
6612:
6607:
6602:
6597:
6592:
6587:
6582:
6577:
6572:
6567:
6562:
6557:
6552:
6547:
6542:
6537:
6532:
6527:
6522:
6517:
6512:
6507:
6502:
6497:
6492:
6487:
6482:
6477:
6472:
6467:
6462:
6457:
6452:
6447:
6442:
6437:
6432:
6427:
6422:
6417:
6412:
6407:
6402:
6397:
6392:
6387:
6382:
6377:
6372:
6366:
6364:
6358:
6357:
6355:
6354:
6349:
6344:
6339:
6334:
6329:
6324:
6319:
6314:
6309:
6304:
6299:
6294:
6289:
6284:
6279:
6274:
6269:
6267:Propylbarbital
6264:
6259:
6254:
6249:
6244:
6239:
6234:
6229:
6224:
6219:
6214:
6209:
6204:
6199:
6194:
6189:
6184:
6179:
6174:
6169:
6164:
6159:
6154:
6149:
6144:
6142:Crotylbarbital
6139:
6134:
6129:
6124:
6119:
6114:
6109:
6107:Brophebarbital
6104:
6102:Brallobarbital
6099:
6094:
6089:
6084:
6079:
6074:
6069:
6064:
6059:
6053:
6051:
6045:
6044:
6042:
6041:
6036:
6031:
6026:
6021:
6013:
6005:
6000:
5995:
5990:
5988:Methylpentynol
5985:
5980:
5975:
5970:
5965:
5960:
5950:
5945:
5940:
5935:
5929:
5927:
5921:
5920:
5914:
5909:
5907:
5906:
5899:
5892:
5884:
5875:
5874:
5860:
5857:
5856:
5853:
5852:
5850:
5849:
5841:
5839:
5828:
5827:
5825:
5824:
5816:
5814:
5800:
5796:
5795:
5792:
5791:
5788:
5787:
5785:
5784:
5779:
5774:
5769:
5764:
5759:
5757:Mefenamic acid
5754:
5749:
5744:
5738:
5736:
5727:
5723:
5722:
5719:
5718:
5716:
5715:
5713:Phenanthridine
5710:
5705:
5700:
5695:
5690:
5684:
5682:
5676:
5675:
5673:
5672:
5667:
5662:
5656:
5654:
5645:
5634:
5633:
5630:
5629:
5627:
5626:
5620:
5618:
5612:
5611:
5609:
5608:
5603:
5598:
5593:
5588:
5583:
5578:
5573:
5568:
5563:
5557:
5555:
5546:
5532:
5526:
5525:
5522:
5521:
5518:
5517:
5515:
5514:
5509:
5504:
5499:
5494:
5488:
5486:
5477:
5466:
5465:
5462:
5461:
5459:
5458:
5452:
5450:
5444:
5443:
5441:
5440:
5435:
5430:
5424:
5422:
5413:
5402:
5401:
5398:
5397:
5395:
5394:
5389:
5384:
5379:
5374:
5361:Atracotoxins (
5359:
5353:
5351:
5345:
5344:
5342:
5341:
5336:
5331:
5321:
5316:
5307:
5306:
5304:Zetekitoxin AB
5301:
5296:
5291:
5286:
5277:
5276:
5271:
5266:
5261:
5256:
5251:
5246:
5241:
5236:
5231:
5222:
5221:
5216:
5211:
5206:
5204:Proxymetacaine
5201:
5196:
5191:
5186:
5181:
5176:
5171:
5166:
5161:
5156:
5151:
5146:
5141:
5136:
5131:
5126:
5121:
5116:
5114:Chloroprocaine
5111:
5106:
5101:
5087:
5082:
5077:
5072:
5060:
5059:
5054:
5049:
5044:
5039:
5034:
5029:
5024:
5019:
5014:
5009:
5004:
4999:
4994:
4989:
4984:
4979:
4974:
4969:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4929:
4920:
4919:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4874:
4869:
4864:
4859:
4854:
4849:
4844:
4839:
4834:
4825:
4824:
4815:
4813:
4804:
4790:
4784:
4783:
4780:
4779:
4776:
4775:
4773:
4772:
4766:
4764:
4758:
4757:
4755:
4754:
4749:
4744:
4739:
4733:
4731:
4722:
4711:
4710:
4707:
4706:
4704:
4703:
4698:
4693:
4688:
4683:
4678:
4669:
4663:
4661:
4655:
4654:
4652:
4651:
4646:
4637:
4631:
4629:
4620:
4612:
4606:
4605:
4602:
4601:
4599:
4598:
4581:
4580:
4575:
4570:
4565:
4560:
4555:
4550:
4545:
4540:
4535:
4530:
4525:
4520:
4515:
4502:
4495:
4493:
4487:
4486:
4484:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4426:
4425:
4420:
4415:
4410:
4405:
4400:
4395:
4390:
4388:Glyclopyramide
4385:
4380:
4375:
4370:
4365:
4360:
4355:
4350:
4345:
4343:Chlorpropamide
4340:
4335:
4322:
4315:
4313:
4304:
4293:
4292:
4289:
4288:
4286:
4285:
4280:
4270:
4264:
4262:
4256:
4255:
4253:
4252:
4247:
4242:
4232:
4226:
4225:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4130:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4090:
4088:Clarithromycin
4085:
4080:
4078:Chlorpromazine
4075:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4030:
4025:
4017:
4009:
4008:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3903:
3898:
3893:
3888:
3883:
3878:
3873:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3833:
3827:
3825:
3816:
3802:
3796:
3795:
3792:
3791:
3788:
3787:
3785:
3784:
3772:
3770:
3764:
3763:
3761:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3710:
3705:
3700:
3698:Paramethadione
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3555:
3546:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3473:gabapentinoids
3466:
3460:
3459:
3454:
3449:
3444:
3439:
3434:
3429:
3424:
3419:
3414:
3409:
3404:
3399:
3394:
3389:
3384:
3379:
3374:Non-selective:
3370:
3369:
3364:
3359:
3354:
3349:
3344:
3339:
3327:
3326:
3314:
3313:
3311:ω-Agatoxin IVB
3308:
3306:ω-Agatoxin IVA
3296:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3263:Huwentoxin XVI
3260:
3255:
3250:
3238:
3237:
3232:
3227:
3222:
3217:
3215:Cyproheptadine
3212:
3207:
3202:
3197:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3140:
3135:
3130:
3125:
3110:
3105:
3100:
3095:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2995:
2990:
2985:
2980:
2975:
2973:Levniguldipine
2970:
2965:
2960:
2955:
2950:
2945:
2940:
2935:
2930:
2925:
2920:
2915:
2913:Dexniguldipine
2910:
2905:
2900:
2895:
2890:
2885:
2880:
2862:
2860:
2851:
2837:
2831:
2830:
2825:
2823:
2822:
2815:
2808:
2800:
2791:
2790:
2787:
2786:
2785:
2784:
2781:
2770:
2764:
2758:
2757:
2754:
2753:
2750:
2749:
2747:
2746:
2741:
2736:
2731:
2726:
2721:
2716:
2711:
2706:
2701:
2695:
2693:
2689:
2688:
2686:
2685:
2680:
2675:
2670:
2665:
2653:
2651:
2642:
2638:
2637:
2634:
2633:
2631:
2630:
2624:
2622:
2616:
2615:
2613:
2612:
2607:
2602:
2597:
2585:
2578:Gabapentinoids
2570:
2565:
2550:
2548:Paramethadione
2545:
2533:
2531:
2525:
2524:
2522:
2521:
2516:
2511:
2506:
2501:
2489:
2484:
2479:
2467:
2462:
2447:
2442:
2437:
2422:
2417:
2412:
2400:
2398:
2389:
2381:
2380:
2377:
2376:
2374:
2373:
2356:GABAR agonists
2351:
2349:
2345:
2344:
2342:
2341:
2336:
2331:
2326:
2321:(and related):
2314:
2312:
2306:
2305:
2303:
2302:
2297:
2292:
2287:
2284:sodium bromide
2266:
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2216:
2201:
2196:
2191:
2186:
2181:
2169:
2167:
2159:
2151:
2145:
2144:
2134:
2132:
2131:
2124:
2117:
2109:
2102:
2101:
2091:(5): 613–622.
2076:
2032:
2030:
2027:
2024:
2023:
1987:
1959:
1923:
1897:
1880:(2010-06-25).
1872:
1844:
1823:
1802:
1773:(3): 273–294.
1753:
1709:
1705:
1694:
1665:(3): 229–241.
1645:
1596:
1569:(2): 197–216.
1548:
1518:
1490:
1470:
1424:
1376:
1347:(6): 153–154.
1320:
1291:(4): 345–352.
1268:
1241:(2): 253–262.
1222:
1184:
1166:
1155:
1130:
1103:(2): 175–182.
1086:
1085:
1083:
1080:
1055:
1052:
1018:
1015:
978:
975:
938:
935:
913:Retigabine is
895:
892:
868:
865:
863:
860:
856:P-glycoprotein
820:
817:
801:slurred speech
776:
773:
704:anticonvulsant
683:
682:
680:
679:
676:
674:
671:
663:
662:
661:
658:
657:
655:
654:
651:
643:
642:
641:
638:
637:
635:
634:
626:
624:
616:
615:
609:
603:
602:
599:
593:
584:
578:
573:
567:
566:
562:
561:
551:
543:
542:
540:
539:
531:DTXSID40164615
526:
524:
511:
510:
508:
507:
499:
497:
491:
490:
488:
487:
479:
477:
471:
470:
468:
467:
459:
457:
451:
450:
448:
447:
439:
437:
431:
430:
428:
427:
419:
417:
411:
410:
408:
407:
399:
397:
391:
390:
388:
387:
379:
377:
366:
365:
363:
362:
354:
352:
346:
345:
343:
342:
335:
327:
326:
325:
322:
321:
317:
316:
310:
304:
303:
300:
291:
290:
273:
267:
266:
263:
257:
256:
253:
247:
246:
239:
238:
236:
235:
223:
210:
196:
194:
188:
187:
183:
182:
180:
179:
166:
164:
158:
157:
152:
150:administration
144:
143:
141:
140:
123:
105:
103:
97:
96:
89:
83:
82:
75:
65:
64:
52:
48:
47:
44:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
8587:
8576:
8573:
8571:
8568:
8566:
8563:
8561:
8558:
8556:
8553:
8551:
8548:
8546:
8543:
8542:
8540:
8530:
8520:
8516:
8505:
8504:
8500:
8496:
8493:
8487:
8481:
8478:
8476:
8473:
8471:
8468:
8466:
8463:
8460:
8459:
8455:
8451:
8447:
8446:isovaleramide
8443:
8439:
8436:
8434:
8431:
8428:
8424:
8421:
8418:
8414:
8410:
8406:
8403:
8401:
8398:
8396:
8393:
8391:
8388:
8386:
8383:
8381:
8378:
8376:
8373:
8371:
8368:
8366:
8363:
8361:
8358:
8356:
8353:
8351:
8348:
8346:
8343:
8340:
8336:
8332:
8328:
8324:
8321:
8319:
8316:
8314:
8311:
8309:
8306:
8304:
8301:
8299:
8296:
8294:
8291:
8288:
8284:
8283:niflumic acid
8280:
8276:
8272:
8269:
8267:
8264:
8262:
8259:
8257:
8254:
8252:
8249:
8246:
8242:
8238:
8234:
8230:
8227:
8225:
8222:
8220:
8217:
8215:
8212:
8210:
8209:Clomethiazole
8207:
8205:
8204:Chlormezanone
8202:
8200:
8197:
8195:
8194:Carbamazepine
8192:
8189:
8185:
8181:
8177:
8174:
8171:
8167:
8164:
8162:
8159:
8157:
8154:
8152:
8149:
8147:
8144:
8143:
8141:
8137:
8131:
8128:
8126:
8123:
8121:
8118:
8116:
8113:
8111:
8108:
8106:
8103:
8101:
8098:
8096:
8093:
8091:
8088:
8086:
8083:
8081:
8078:
8076:
8073:
8071:
8070:Nitrous oxide
8068:
8066:
8063:
8061:
8058:
8056:
8053:
8051:
8048:
8046:
8043:
8041:
8038:
8036:
8033:
8031:
8028:
8026:
8023:
8021:
8018:
8016:
8013:
8011:
8008:
8006:
8003:
8001:
8000:Diethyl ether
7998:
7996:
7993:
7991:
7988:
7986:
7983:
7981:
7978:
7976:
7973:
7971:
7968:
7966:
7963:
7961:
7958:
7956:
7953:
7951:
7948:
7946:
7943:
7941:
7938:
7936:
7933:
7931:
7928:
7926:
7923:
7921:
7918:
7917:
7915:
7913:
7909:
7905:
7899:
7896:
7894:
7891:
7889:
7886:
7884:
7881:
7879:
7876:
7874:
7871:
7869:
7866:
7864:
7861:
7859:
7856:
7854:
7851:
7850:
7848:
7846:
7842:
7836:
7833:
7831:
7828:
7826:
7823:
7821:
7818:
7817:
7815:
7813:
7809:
7803:
7802:Pyrithyldione
7800:
7798:
7795:
7793:
7790:
7788:
7785:
7784:
7782:
7780:
7776:
7770:
7767:
7765:
7762:
7760:
7757:
7756:
7754:
7752:
7748:
7742:
7739:
7737:
7734:
7732:
7729:
7727:
7724:
7722:
7719:
7717:
7714:
7712:
7709:
7707:
7704:
7702:
7699:
7697:
7694:
7692:
7689:
7687:
7684:
7682:
7679:
7677:
7674:
7672:
7669:
7667:
7664:
7662:
7659:
7657:
7654:
7652:
7649:
7647:
7644:
7642:
7639:
7637:
7634:
7632:
7629:
7627:
7624:
7622:
7619:
7617:
7614:
7612:
7609:
7607:
7604:
7602:
7599:
7597:
7593:
7590:
7589:
7586:
7583:
7581:
7578:
7576:
7573:
7571:
7568:
7566:
7563:
7561:
7558:
7556:
7553:
7551:
7547:
7546:
7542:
7541:
7538:
7535:
7533:
7530:
7528:
7525:
7523:
7520:
7518:
7514:
7513:
7509:
7508:
7505:
7502:
7500:
7497:
7495:
7492:
7490:
7487:
7485:
7482:
7480:
7476:
7475:
7471:
7470:
7468:
7466:
7462:
7456:
7453:
7451:
7448:
7446:
7443:
7441:
7438:
7436:
7433:
7431:
7428:
7426:
7423:
7421:
7418:
7416:
7413:
7411:
7408:
7406:
7403:
7401:
7398:
7396:
7393:
7391:
7388:
7386:
7383:
7381:
7378:
7376:
7373:
7371:
7368:
7366:
7363:
7361:
7358:
7356:
7353:
7351:
7348:
7346:
7343:
7341:
7338:
7336:
7333:
7331:
7327:
7325:
7322:
7320:
7317:
7315:
7312:
7310:
7307:
7305:
7302:
7300:
7297:
7295:
7292:
7291:
7289:
7287:
7283:
7277:
7274:
7272:
7269:
7267:
7264:
7262:
7259:
7257:
7254:
7252:
7249:
7248:
7246:
7244:
7240:
7234:
7231:
7229:
7226:
7224:
7221:
7219:
7216:
7214:
7211:
7209:
7206:
7204:
7201:
7199:
7196:
7194:
7191:
7189:
7186:
7184:
7181:
7179:
7176:
7174:
7171:
7169:
7166:
7164:
7161:
7160:
7158:
7155:
7151:
7145:
7142:
7140:
7137:
7135:
7132:
7131:
7129:
7127:
7123:
7117:
7114:
7111:
7107:
7104:
7102:
7099:
7097:
7094:
7092:
7089:
7087:
7084:
7082:
7079:
7077:
7074:
7072:
7069:
7067:
7064:
7062:
7059:
7057:
7054:
7052:
7049:
7047:
7044:
7043:
7041:
7039:
7035:
7029:
7026:
7024:
7021:
7019:
7016:
7014:
7011:
7009:
7008:Phenprobamate
7006:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6986:
6984:
6981:
6979:
6976:
6974:
6973:Hexapropymate
6971:
6969:
6966:
6964:
6961:
6959:
6956:
6954:
6951:
6949:
6948:Difebarbamate
6946:
6944:
6941:
6939:
6936:
6934:
6931:
6929:
6926:
6925:
6923:
6921:
6917:
6911:
6908:
6906:
6903:
6901:
6898:
6896:
6893:
6891:
6888:
6886:
6883:
6881:
6878:
6876:
6873:
6871:
6868:
6866:
6863:
6861:
6858:
6856:
6853:
6851:
6848:
6846:
6843:
6841:
6838:
6836:
6833:
6831:
6828:
6826:
6823:
6821:
6818:
6816:
6813:
6811:
6808:
6806:
6803:
6801:
6798:
6796:
6793:
6791:
6788:
6786:
6783:
6781:
6778:
6776:
6773:
6771:
6768:
6766:
6763:
6761:
6760:Nortetrazepam
6758:
6756:
6753:
6751:
6748:
6746:
6743:
6741:
6738:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6718:
6716:
6713:
6711:
6708:
6706:
6703:
6701:
6698:
6696:
6693:
6691:
6688:
6686:
6683:
6681:
6678:
6676:
6673:
6671:
6668:
6666:
6663:
6661:
6658:
6656:
6653:
6651:
6648:
6646:
6643:
6641:
6638:
6636:
6633:
6631:
6628:
6626:
6623:
6621:
6620:Flutoprazepam
6618:
6616:
6613:
6611:
6608:
6606:
6603:
6601:
6600:Flunitrazolam
6598:
6596:
6595:Flunitrazepam
6593:
6591:
6588:
6586:
6585:Flubromazolam
6583:
6581:
6580:Flubromazepam
6578:
6576:
6573:
6571:
6568:
6566:
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6521:
6518:
6516:
6513:
6511:
6508:
6506:
6503:
6501:
6498:
6496:
6493:
6491:
6488:
6486:
6483:
6481:
6480:Cloniprazepam
6478:
6476:
6473:
6471:
6468:
6466:
6463:
6461:
6458:
6456:
6453:
6451:
6448:
6446:
6443:
6441:
6438:
6436:
6433:
6431:
6428:
6426:
6423:
6421:
6418:
6416:
6413:
6411:
6408:
6406:
6403:
6401:
6398:
6396:
6393:
6391:
6388:
6386:
6383:
6381:
6378:
6376:
6373:
6371:
6370:2-Oxoquazepam
6368:
6367:
6365:
6363:
6359:
6353:
6350:
6348:
6345:
6343:
6340:
6338:
6335:
6333:
6330:
6328:
6325:
6323:
6320:
6318:
6315:
6313:
6312:Thialbarbital
6310:
6308:
6307:Tetrabarbital
6305:
6303:
6300:
6298:
6295:
6293:
6292:Spirobarbital
6290:
6288:
6285:
6283:
6280:
6278:
6275:
6273:
6272:Proxibarbital
6270:
6268:
6265:
6263:
6262:Propallylonal
6260:
6258:
6255:
6253:
6250:
6248:
6245:
6243:
6242:Phenobarbital
6240:
6238:
6235:
6233:
6232:Pentobarbital
6230:
6228:
6225:
6223:
6222:Narcobarbital
6220:
6218:
6215:
6213:
6210:
6208:
6205:
6203:
6200:
6198:
6195:
6193:
6190:
6188:
6187:Heptobarbital
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6168:
6165:
6163:
6160:
6158:
6157:Difebarbamate
6155:
6153:
6150:
6148:
6147:Cyclobarbital
6145:
6143:
6140:
6138:
6135:
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6115:
6113:
6110:
6108:
6105:
6103:
6100:
6098:
6095:
6093:
6092:Benzobarbital
6090:
6088:
6085:
6083:
6080:
6078:
6075:
6073:
6070:
6068:
6065:
6063:
6060:
6058:
6055:
6054:
6052:
6050:
6046:
6040:
6037:
6035:
6032:
6030:
6027:
6025:
6022:
6020:
6018:
6014:
6012:
6010:
6006:
6004:
6001:
5999:
5996:
5994:
5991:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5969:
5966:
5964:
5963:Ethchlorvynol
5961:
5958:
5954:
5951:
5949:
5946:
5944:
5941:
5939:
5936:
5934:
5931:
5930:
5928:
5926:
5922:
5918:
5905:
5900:
5898:
5893:
5891:
5886:
5885:
5882:
5872:
5871:
5867:
5864:
5858:
5847:
5843:
5842:
5840:
5835:
5829:
5822:
5818:
5817:
5815:
5810:
5804:
5801:
5797:
5783:
5780:
5778:
5775:
5773:
5770:
5768:
5767:Niflumic acid
5765:
5763:
5760:
5758:
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5739:
5737:
5735:
5731:
5728:
5724:
5714:
5711:
5709:
5706:
5704:
5701:
5699:
5696:
5694:
5691:
5689:
5686:
5685:
5683:
5681:
5677:
5671:
5668:
5666:
5663:
5661:
5660:Glibenclamide
5658:
5657:
5655:
5653:
5649:
5646:
5641:
5635:
5625:
5622:
5621:
5619:
5617:
5613:
5607:
5606:Niflumic acid
5604:
5602:
5599:
5597:
5594:
5592:
5591:Glibenclamide
5589:
5587:
5584:
5582:
5579:
5577:
5574:
5572:
5569:
5567:
5564:
5562:
5559:
5558:
5556:
5554:
5550:
5547:
5542:
5536:
5533:
5531:
5527:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5489:
5487:
5485:
5481:
5478:
5473:
5467:
5457:
5454:
5453:
5451:
5449:
5445:
5439:
5436:
5434:
5431:
5429:
5426:
5425:
5423:
5421:
5417:
5414:
5409:
5403:
5393:
5390:
5388:
5387:Grayanotoxins
5385:
5383:
5380:
5378:
5377:Batrachotoxin
5375:
5372:
5368:
5364:
5363:ω-Atracotoxin
5360:
5358:
5355:
5354:
5352:
5350:
5346:
5340:
5337:
5335:
5332:
5329:
5325:
5322:
5320:
5317:
5315:
5314:Buprenorphine
5312:
5309:
5308:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5279:
5278:
5275:
5272:
5270:
5267:
5265:
5262:
5260:
5257:
5255:
5252:
5250:
5247:
5245:
5242:
5240:
5237:
5235:
5232:
5230:
5227:
5224:
5223:
5220:
5217:
5215:
5212:
5210:
5207:
5205:
5202:
5200:
5197:
5195:
5192:
5190:
5187:
5185:
5182:
5180:
5177:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5147:
5145:
5142:
5140:
5137:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5117:
5115:
5112:
5110:
5107:
5105:
5102:
5099:
5095:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5069:
5065:
5062:
5061:
5058:
5055:
5053:
5050:
5048:
5047:Valproic acid
5045:
5043:
5040:
5038:
5035:
5033:
5030:
5028:
5025:
5023:
5020:
5018:
5015:
5013:
5010:
5008:
5005:
5003:
5000:
4998:
4995:
4993:
4992:Oxitriptyline
4990:
4988:
4987:Oxcarbazepine
4985:
4983:
4980:
4978:
4977:Licarbazepine
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4932:Carbamazepine
4930:
4928:
4925:
4922:
4921:
4918:
4915:
4913:
4910:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4873:
4870:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4827:
4826:
4823:
4820:
4819:Antianginals:
4817:
4816:
4814:
4812:
4808:
4805:
4800:
4794:
4791:
4789:
4785:
4771:
4768:
4767:
4765:
4763:
4759:
4753:
4752:Norfluoxetine
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4734:
4732:
4730:
4726:
4723:
4718:
4712:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4686:Niflumic acid
4684:
4682:
4679:
4677:
4674:
4672:
4665:
4664:
4662:
4660:
4656:
4650:
4647:
4645:
4642:
4640:
4633:
4632:
4630:
4628:
4624:
4621:
4616:
4607:
4597:
4594:
4589:
4583:
4582:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4556:
4554:
4551:
4549:
4546:
4544:
4541:
4539:
4538:Levcromakalim
4536:
4534:
4531:
4529:
4526:
4524:
4521:
4519:
4516:
4514:
4511:
4506:
4497:
4496:
4494:
4492:
4488:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4434:
4428:
4427:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4339:
4336:
4334:
4333:Acetohexamide
4331:
4326:
4317:
4316:
4314:
4312:
4308:
4305:
4300:
4294:
4284:
4281:
4279:
4276:
4274:
4266:
4265:
4263:
4261:
4257:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4228:
4227:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4178:Roxithromycin
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4015:
4011:
4010:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3871:Charybdotoxin
3869:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3828:
3826:
3824:
3820:
3817:
3812:
3806:
3803:
3801:
3797:
3783:
3780:
3778:
3774:
3773:
3771:
3769:
3765:
3759:
3756:
3754:
3753:Trimethadione
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3593:Diproteverine
3591:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3554:
3551:
3548:
3547:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3470:
3462:
3461:
3458:
3455:
3453:
3452:Ruthenium red
3450:
3448:
3445:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3427:Levetiracetam
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3377:ω-Agatoxin TK
3375:
3372:
3371:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3347:Niflumic acid
3345:
3343:
3340:
3338:
3335:
3333:
3329:
3328:
3325:
3322:
3320:
3316:
3315:
3312:
3309:
3307:
3304:
3302:
3298:
3297:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3240:
3239:
3236:
3233:
3231:
3228:
3226:
3223:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2968:Levamlodipine
2966:
2964:
2963:Lercanidipine
2961:
2959:
2956:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2870:
2868:
2864:
2863:
2861:
2859:
2855:
2852:
2847:
2841:
2838:
2836:
2832:
2828:
2821:
2816:
2814:
2809:
2807:
2802:
2801:
2798:
2782:
2780:
2777:
2776:
2774:
2771:
2768:
2765:
2763:
2760:
2759:
2755:
2745:
2742:
2740:
2739:Levetiracetam
2737:
2735:
2732:
2730:
2727:
2725:
2722:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2697:
2696:
2694:
2690:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2668:Ethoxzolamide
2666:
2664:
2663:Acetazolamide
2661:
2659:
2655:
2654:
2652:
2650:
2649:CA inhibitors
2646:
2643:
2639:
2629:
2626:
2625:
2623:
2621:
2617:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2589:
2586:
2584:
2581:
2579:
2574:
2571:
2569:
2566:
2564:
2560:
2559:
2554:
2553:Trimethadione
2551:
2549:
2546:
2544:
2541:
2539:
2535:
2534:
2532:
2530:
2526:
2520:
2517:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2493:
2492:Oxcarbazepine
2490:
2488:
2485:
2483:
2482:Carbamazepine
2480:
2478:
2476:
2471:
2468:
2466:
2463:
2461:
2458:
2456:
2451:
2448:
2446:
2443:
2441:
2438:
2436:
2433:
2431:
2426:
2423:
2421:
2418:
2416:
2413:
2411:
2408:
2406:
2402:
2401:
2399:
2397:
2393:
2390:
2388:
2382:
2372:
2369:
2367:
2362:
2358:
2357:
2353:
2352:
2350:
2346:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2316:
2315:
2313:
2311:
2307:
2301:
2298:
2296:
2293:
2291:
2288:
2285:
2281:
2277:
2274:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2226:
2225:
2220:
2217:
2215:
2211:
2210:
2205:
2202:
2200:
2199:Phenobarbital
2197:
2195:
2194:Pentobarbital
2192:
2190:
2187:
2185:
2182:
2180:
2177:
2175:
2171:
2170:
2168:
2166:
2163:
2155:
2152:
2150:
2146:
2141:
2137:
2130:
2125:
2123:
2118:
2116:
2111:
2110:
2107:
2098:
2094:
2090:
2086:
2082:
2077:
2073:
2069:
2064:
2059:
2055:
2051:
2047:
2043:
2039:
2034:
2033:
2028:
2013:on 2012-04-02
2009:
2005:
1998:
1991:
1988:
1977:
1970:
1967:(2005–2006).
1963:
1960:
1952:
1948:
1944:
1937:
1933:
1927:
1924:
1919:
1915:
1908:
1901:
1898:
1887:
1883:
1876:
1873:
1862:
1858:
1851:
1849:
1845:
1833:
1827:
1824:
1812:
1806:
1803:
1798:
1794:
1789:
1784:
1780:
1776:
1772:
1768:
1764:
1757:
1754:
1749:
1745:
1740:
1735:
1730:
1725:
1721:
1717:
1713:
1698:
1695:
1690:
1686:
1681:
1676:
1672:
1668:
1664:
1660:
1656:
1649:
1646:
1641:
1637:
1632:
1627:
1623:
1619:
1615:
1611:
1607:
1600:
1597:
1592:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1557:
1555:
1553:
1549:
1537:
1531:
1529:
1527:
1525:
1523:
1519:
1508:
1504:
1497:
1495:
1491:
1486:
1485:
1480:
1474:
1471:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1431:
1429:
1425:
1420:
1416:
1412:
1408:
1404:
1400:
1396:
1392:
1385:
1383:
1381:
1377:
1372:
1368:
1363:
1358:
1354:
1350:
1346:
1342:
1338:
1331:
1329:
1327:
1325:
1321:
1316:
1312:
1307:
1302:
1298:
1294:
1290:
1286:
1282:
1275:
1273:
1269:
1264:
1260:
1256:
1252:
1248:
1244:
1240:
1236:
1229:
1227:
1223:
1218:
1214:
1210:
1206:
1202:
1198:
1191:
1189:
1185:
1180:
1176:
1170:
1167:
1164:
1159:
1156:
1140:
1134:
1131:
1126:
1122:
1118:
1114:
1110:
1106:
1102:
1098:
1091:
1088:
1081:
1079:
1077:
1073:
1069:
1065:
1061:
1053:
1051:
1049:
1045:
1040:
1038:
1034:
1029:
1024:
1016:
1014:
1012:
1008:
1004:
999:
996:
995:significantly
991:
988:
984:
976:
974:
972:
968:
964:
960:
956:
952:
948:
947:animal models
944:
936:
934:
932:
928:
924:
920:
916:
911:
909:
905:
901:
893:
891:
887:
885:
881:
878:
874:
866:
861:
859:
857:
853:
849:
844:
842:
838:
837:carbamazepine
834:
830:
826:
818:
816:
814:
813:double vision
810:
806:
802:
798:
794:
790:
786:
782:
774:
772:
770:
766:
762:
758:
754:
750:
745:
743:
739:
736:
735:United States
732:
728:
724:
720:
716:
712:
709:
705:
701:
697:
693:
689:
675:
670:
666:
659:
650:
646:
639:
632:
628:
627:
625:
622:
617:
610:
608:
604:
574:
572:
568:
563:
559:
555:
552:
550:
548:ECHA InfoCard
544:
536:
532:
528:
527:
525:
516:
512:
505:
501:
500:
498:
496:
492:
485:
481:
480:
478:
476:
472:
465:
461:
460:
458:
456:
452:
445:
441:
440:
438:
436:
432:
425:
421:
420:
418:
416:
412:
405:
401:
400:
398:
396:
392:
385:
381:
380:
378:
371:
367:
360:
356:
355:
353:
351:
347:
339:
334:
330:
323:
318:
314:
311:
309:
305:
301:
299:
292:
288:
284:
280:
277:
274:
272:
268:
264:
262:
258:
254:
252:
248:
244:
240:
234:
224:
221:
211:
208:
198:
197:
195:
193:
189:
184:
176:
171:
168:
167:
165:
163:
159:
156:
153:
151:
145:
138:
134:
124:
121:
116:
107:
106:
104:
102:
98:
94:
90:
88:
84:
80:
76:
74:
70:
66:
57:
53:
49:
45:
43:
39:
36:Clinical data
34:
30:
25:
8575:Orphan drugs
8491:
8490:
8461:
8384:
8318:Lavender oil
8060:Nitric oxide
7980:Cryofluorane
7925:Acetophenone
7883:Methaqualone
7878:Mecloqualone
7873:Mebroqualone
7863:Diproqualone
7858:Cloroqualone
7787:Glutethimide
7591:
7543:
7510:
7472:
7445:Testosterone
7410:Progesterone
7375:Hydroxydione
7324:Androsterone
7251:Acecarbromal
7156:constituents
6943:Cyclarbamate
6933:Carisoprodol
6705:Metaclazepam
6700:Menitrazepam
6690:Meclonazepam
6685:Lormetazepam
6615:Flutemazepam
6440:Ciclotizolam
6430:Carburazepam
6322:Thiobarbital
6282:Secobarbital
6247:Phetharbital
6227:Nealbarbital
6212:Methohexital
6197:Hexobarbital
6132:Butallylonal
6127:Butobarbital
6082:Barbexaclone
6077:Aprobarbital
6062:Allobarbital
6049:Barbiturates
6016:
6008:
5998:Petrichloral
5862:
5861:
5772:Talniflumate
5310:
5299:Tetrodotoxin
5289:Neosaxitoxin
5280:
5225:
5199:Propoxycaine
5134:Dimethocaine
5067:
5063:
5032:Valnoctamide
4962:Fosphenytoin
4923:
4897:Procainamide
4887:Pilsicainide
4842:Disopyramide
4828:
4818:
4666:
4634:
4584:
4498:
4466:Ethosuximide
4451:Cloperastine
4429:
4398:Metahexamide
4393:Glycyclamide
4353:Glibornuride
4318:
4282:
4267:
4229:
4208:Thioridazine
4163:Promethazine
4148:Orphenadrine
4138:Ketoconazole
4123:Erythromycin
4012:
3775:
3703:Phensuximide
3683:Ochratoxin A
3623:Ethosuximide
3549:
3471:-selective (
3463:
3373:
3330:
3317:
3299:
3248:ω-Conotoxins
3241:
3191:
3173:Norverapamil
3138:Dexverapamil
3116:
3090:derivatives:
3086:
3083:Vatanidipine
3078:Trombodipine
3043:Palonidipine
3028:Nitrendipine
2983:Mepirodipine
2888:Azelnidipine
2871:
2865:
2729:Fenfluramine
2709:Brivaracetam
2658:Sulfonamides
2656:
2627:
2591:
2576:
2573:Phensuximide
2563:Ethosuximide
2558:Succinimides
2556:
2536:
2495:
2475:Carboxamides
2473:
2453:
2428:
2415:Fosphenytoin
2403:
2364:
2354:
2317:
2272:
2222:
2207:
2179:Barbexaclone
2174:Barbiturates
2172:
2088:
2084:
2045:
2041:
2015:. Retrieved
2008:the original
1990:
1979:. Retrieved
1962:
1951:the original
1946:
1942:
1926:
1917:
1913:
1900:
1889:. Retrieved
1875:
1864:. Retrieved
1836:. Retrieved
1826:
1815:. Retrieved
1805:
1770:
1766:
1756:
1719:
1715:
1697:
1662:
1658:
1648:
1613:
1609:
1599:
1566:
1562:
1540:. Retrieved
1510:. Retrieved
1482:
1473:
1440:
1436:
1394:
1390:
1344:
1340:
1288:
1284:
1238:
1234:
1200:
1196:
1178:
1169:
1158:
1146:. Retrieved
1133:
1100:
1096:
1090:
1072:USAN Council
1067:
1057:
1041:
1020:
1000:
983:double-blind
980:
940:
918:
912:
897:
888:
870:
862:Pharmacology
851:
845:
822:
819:Interactions
778:
746:
741:
730:
695:
687:
686:
337:
295:Elimination
289:not involved
192:Legal status
186:Legal status
101:License data
8400:Stiripentol
8395:Seproxetine
8365:Niacinamide
8345:Loreclezole
8166:Avermectins
8130:Vinyl ether
8100:Sevoflurane
8080:Paraldehyde
8030:Halopropane
7853:Afloqualone
7835:Tracazolate
7830:ICI-190,622
7820:Cartazolate
7797:Piperidione
7792:Methyprylon
7759:Fospropofol
7681:Pipequaline
7489:Pazinaclone
7479:Eszopiclone
7335:Cholesterol
7319:Androstenol
7243:Monoureides
7223:Methysticin
7023:Tetrabamate
7003:Pentabamate
6993:Meprobamate
6963:Febarbamate
6928:Carisbamate
6880:Triflubazam
6870:Tolufazepam
6830:Rilmazafone
6825:Remimazolam
6800:Proflazepam
6785:Pivoxazepam
6745:Nitrazepate
6735:Nimetazepam
6670:Lopirazepam
6640:Haloxazolam
6590:Fludiazepam
6535:Doxefazepam
6510:Delorazepam
6490:Clotiazepam
6485:Clorazepate
6450:Cinolazepam
6347:Vinbarbital
6302:Tetrabamate
6257:Probarbital
6237:Phenallymal
6202:Metharbital
6177:Febarbamate
6072:Amobarbital
5973:Isopropanol
5943:Chloralodol
5438:Triamterene
5392:Poneratoxin
5382:Ciguatoxins
5269:Raxatrigine
5264:Ralfinamide
5259:PF-05089771
5254:PF-04531083
5226:Analgesics:
5184:Piperocaine
5169:Meprylcaine
5164:Mepivacaine
5119:Cinchocaine
5098:Ropivacaine
5090:Bupivacaine
5017:Sipatrigine
5002:Pheneturide
4997:Phenacemide
4982:Mephenytoin
4967:Lamotrigine
4947:Elpetrigine
4902:Propafenone
4847:Dronedarone
4423:Tolbutamide
4413:Repaglinide
4408:Nateglinide
4403:Mitiglinide
4383:Glisoxepide
4368:Glimepiride
4358:Glicaramide
4338:Carbutamide
4240:Linopirdine
4223:Vernakalant
4213:Tolterodine
4203:Terfenadine
4193:Tamulotoxin
4188:Solifenacin
4158:PNU-282,987
4133:Haloperidol
4128:Gigactonine
4108:Domperidone
4093:Darifenacin
4058:Bedaquiline
4043:Azaspiracid
4006:Vernakalant
3941:Linopirdine
3901:Dronedarone
3891:Dendrotoxin
3876:Clamikalant
3748:Tolperisone
3743:Tetrandrine
3733:Sipatrigine
3728:Silperisone
3713:Prenylamine
3653:Lidoflazine
3608:Elpetrigine
3518:Mirogabalin
3422:Lamotrigine
3417:Flunarizine
3412:Efonidipine
3402:Cinnarizine
3397:Cilnidipine
3352:NNC 55-0396
3278:Ralfinamide
3225:Fantofarone
3220:Dronedarone
3205:Budiodarone
3200:Brinazarone
3163:Levemopamil
3063:Sornidipine
3058:Sagandipine
3048:Pranidipine
3023:Nisoldipine
3013:Nilvadipine
3003:Niguldipine
2993:Nicardipine
2958:Lemildipine
2943:Iganidipine
2938:Furnidipine
2903:Cronidipine
2898:Clevidipine
2893:Barnidipine
2883:Aranidipine
2769:from market
2719:Carisbamate
2714:Cannabidiol
2600:Lamotrigine
2504:Lamotrigine
2455:Fatty acids
2450:Pheneturide
2445:Phenacemide
2420:Mephenytoin
2319:Fatty acids
2300:Stiripentol
2295:Paraldehyde
2259:Nimetazepam
2239:Clorazepate
2184:Metharbital
2048:(1): 1–20.
1068:recommended
943:preclinical
927:acetylation
915:metabolized
829:lamotrigine
614: g·mol
554:100.158.123
504:ChEMBL41355
359:150812-12-7
320:Identifiers
283:acetylation
87:MedlinePlus
51:Other names
42:Trade names
8550:Carbamates
8539:Categories
8433:Topiramate
8423:Terpenoids
8380:Propanidid
8370:Org 25,435
8298:Flupirtine
8293:Fluoxetine
8199:Chloralose
8170:ivermectin
8075:Norflurane
8040:Isoflurane
7985:Desflurane
7975:Chloroform
7935:Aliflurane
7868:Etaqualone
7696:SB-205,384
7626:CP-615,003
7621:CL-218,872
7575:Panadiplon
7565:Lorediplon
7494:Suproclone
7455:Zuranolone
7415:Renanolone
7400:Posovolone
7380:Minaxolone
7370:Ganaxolone
7309:Alfaxalone
7304:Alfadolone
7294:Acebrochol
7261:Bromisoval
7139:Metomidate
7126:Imidazoles
7086:Hispidulin
7038:Flavonoids
6998:Nisobamate
6988:Mebutamate
6958:Ethinamate
6953:Emylcamate
6920:Carbamates
6890:Tuclazepam
6865:Tetrazepam
6820:Reclazepam
6795:Premazepam
6775:Phenazepam
6755:Nordazepam
6750:Nitrazolam
6740:Nitrazepam
6720:Motrazepam
6675:Loprazolam
6665:Lofendazam
6650:Imidazenil
6610:Flutazolam
6605:Flurazepam
6575:Fletazepam
6530:Dimdazenil
6525:Diclazepam
6505:Cyprazepam
6495:Cloxazolam
6475:Clonazolam
6470:Clonazepam
6460:Climazolam
6420:Brotizolam
6415:Bromazolam
6410:Bromazepam
6405:Bretazenil
6400:Bentazepam
6390:Arfendazam
6385:Alprazolam
6380:Adinazolam
6352:Vinylbital
6332:Thiopental
6207:Methitural
6122:Buthalital
6117:Butalbital
5968:Isobutanol
5742:Bumetanide
5680:Activators
5670:Piretanide
5665:Lonidamine
5616:Activators
5601:Mibefradil
5596:Mefloquine
5586:Furosemide
5581:Fluoxetine
5561:Crofelemer
5448:Activators
5371:Versutoxin
5367:Robustoxin
5349:Activators
5334:Safinamide
5284:Conotoxins
5219:Trimecaine
5214:Tetracaine
5189:Prilocaine
5179:Orthocaine
5154:Iontocaine
5149:Hexylcaine
5144:Etidocaine
5085:Benzocaine
5075:Amylocaine
5057:Zonisamide
5052:Valpromide
5022:Topiramate
5012:Rufinamide
4972:Lacosamide
4937:Cenobamate
4892:Prajmaline
4882:Moricizine
4877:Mexiletine
4872:Lorcainide
4857:Flecainide
4822:Ranolazine
4762:Activators
4747:Fluoxetine
4691:Nimesulide
4673:-specific:
4659:Activators
4641:-specific:
4593:-specific:
4573:Rilmakalim
4563:Nicorandil
4523:Cromakalim
4510:-specific:
4491:Activators
4481:Tipepidine
4471:Ifenprodil
4446:Caramiphen
4438:-specific:
4418:Tolazamide
4378:Gliquidone
4363:Gliclazide
4330:-specific:
4283:Retigabine
4278:Flupirtine
4275:-specific:
4260:Activators
4237:-specific:
4218:Vanoxerine
4198:Terodiline
4183:Sertindole
4173:Ranolazine
4038:Astemizole
4028:Amiodarone
3996:Terikalant
3971:Pinokalant
3956:Nifekalant
3951:Maurotoxin
3946:Lolitrem B
3936:Kaliotoxin
3896:Dofetilide
3886:Dalazatide
3881:Conotoxins
3851:Amiodarone
3846:Almokalant
3768:Activators
3758:Valperinol
3738:Terodiline
3678:Naftopidil
3668:Mesuximide
3598:Enpiperate
3578:Cycleanine
3563:Bevantolol
3553:Bencyclane
3543:Pregabalin
3533:PD-299,685
3528:PD-217,014
3523:PD-200,347
3513:Imagabalin
3503:Gabapentin
3493:Atagabalin
3483:Arbaclofen
3442:Mibefradil
3437:Loperamide
3432:Lomerizine
3407:Dotarizine
3387:Benidipine
3367:Zonisamide
3283:Safinamide
3258:Caroverine
3210:Celivarone
3158:Gallopamil
3113:Siratiazem
3103:Iprotiazem
3093:Clentiazem
3073:Tiamdipine
3068:Teludipine
3033:Olradipine
3018:Nimodipine
3008:Niludipine
2998:Nifedipine
2988:Mesudipine
2978:Manidipine
2953:Lacidipine
2948:Isradipine
2933:Flordipine
2928:Felodipine
2923:Elnadipine
2918:Elgodipine
2908:Darodipine
2878:Amlodipine
2744:Perampanel
2734:Ganaxolone
2724:Etiracetam
2683:Zonisamide
2678:Topiramate
2628:Retigabine
2610:Zonisamide
2605:Topiramate
2588:Pregabalin
2583:Gabapentin
2568:Mesuximide
2519:Zonisamide
2514:Topiramate
2509:Rufinamide
2499:Lacosamide
2465:Valpromide
2405:Hydantoins
2387:modulators
2339:Vigabatrin
2329:Valpromide
2264:Nitrazepam
2234:Clonazepam
2214:Cenobamate
2209:Carbamates
2149:GABAergics
2017:2010-07-19
1981:2010-07-19
1891:2010-07-19
1866:2010-08-13
1838:2010-07-19
1817:2011-06-13
1542:2011-06-13
1512:2011-06-13
1082:References
971:picrotoxin
884:flupirtine
785:drowsiness
711:epilepsies
688:Retigabine
619:3D model (
607:Molar mass
464:12G01I6BBU
435:ChemSpider
395:IUPHAR/BPS
350:CAS Number
329:IUPAC name
271:Metabolism
233:Schedule V
21:Retigabine
8492:See also:
8454:valerenol
8375:Phenytoin
8355:Monastrol
8313:Lanthanum
8308:KRM-II-81
8271:Fenamates
8266:Etifoxine
8261:Etazepine
8256:Efavirenz
8214:Darigabat
8110:Teflurane
8095:Roflurane
8090:Propylene
8035:Halothane
8020:Fluroxene
8005:Enflurane
7908:Volatiles
7825:Etazolate
7736:Viqualine
7691:RWJ-51204
7656:L-838,417
7646:Imepitoin
7616:CGS-20625
7611:CGS-13767
7596:Adipiplon
7570:Ocinaplon
7532:Saripidem
7527:Necopidem
7504:Zopiclone
7499:Suriclone
7484:Pagoclone
7390:ORG-21465
7385:ORG-20599
7276:Ectylurea
7266:Carbromal
7144:Propoxate
7134:Etomidate
7061:Baicalein
7018:Styramate
7013:Procymate
6983:Lorbamate
6968:Felbamate
6938:Clocental
6910:Zomebazam
6905:Zolazepam
6900:Zapizolam
6895:Uldazepam
6875:Triazolam
6860:Temazepam
6855:Sulazepam
6845:Ro48-8684
6840:Ro48-6791
6835:Ripazepam
6805:Pyrazolam
6780:Pinazepam
6730:Nifoxipam
6715:Midazolam
6710:Mexazolam
6695:Medazepam
6680:Lorazepam
6660:Ketazolam
6655:Irazepine
6645:Iclazepam
6635:Halazepam
6630:Gidazepam
6625:Fosazepam
6545:Estazolam
6540:Elfazepam
6515:Demoxepam
6445:Cinazepam
6425:Camazepam
6395:Avizafone
6317:Thiamylal
6252:Primidone
6182:Heptabarb
6172:Eterobarb
6137:Carbubarb
6034:Triclofos
5933:Brometone
5863:See also:
5762:Mepacrine
5708:Ivacaftor
5624:Carbachol
5507:Ibuprofen
5497:Amiloride
5456:Solnatide
5428:Amiloride
5357:Aconitine
5319:Evenamide
5294:Saxitoxin
5209:Risocaine
5159:Lidocaine
5104:Butacaine
5080:Articaine
5007:Phenytoin
4917:Tocainide
4912:Sparteine
4907:Quinidine
4867:Lorajmine
4862:Lidocaine
4852:Encainide
4837:Aprindine
4578:Sarakalim
4568:Pinacidil
4558:Naminidil
4548:Minoxidil
4543:Mazokalim
4528:Diazoxide
4518:Bimakalim
4513:Aprikalim
4476:Tertiapin
4456:Clozapine
4373:Glipizide
4168:Quinidine
4118:Ergtoxins
4083:Cisapride
4073:BRL-32872
4053:Azimilide
4016:(KCNH2, K
3991:Tedisamil
3976:Quinidine
3966:Paxilline
3931:Inakalant
3926:Ibutilide
3911:Hanatoxin
3866:Bunaftine
3861:Bretylium
3856:Azimilide
3841:Adekalant
3800:Potassium
3782:Bay K8644
3723:Sesamodil
3673:Monatepil
3663:Manoalide
3658:Magnesium
3643:Imepitoin
3633:Fendiline
3613:Ethadione
3603:Eperisone
3583:Dauricine
3558:Berbamine
3469:δ subunit
3273:PD-173212
3188:Verapamil
3178:Ronipamil
3168:Nexopamil
3153:Falipamil
3148:Etripamil
3133:Devapamil
3128:Dagapamil
3108:Nictiazem
3098:Diltiazem
3088:Diltiazem
3038:Oxodipine
2779:Phase III
2767:Withdrawn
2704:Beclamide
2595:Imepitoin
2543:Ethadione
2460:Valproate
2425:Phenytoin
2371:Tiagabine
2361:Progabide
2324:Valproate
2290:Imepitoin
2269:Temazepam
2254:Midazolam
2249:Lorazepam
2219:Felbamate
2204:Primidone
1437:Neurology
1391:CNS Drugs
1033:scheduled
1031:had been
841:clearance
833:phenytoin
789:dizziness
715:developed
696:ezogabine
308:Excretion
297:half-life
148:Routes of
137:Ezogabine
73:Drugs.com
8529:Medicine
8480:TCS-1205
8475:TCS-1105
8465:α-Pinene
8438:Valerian
8413:tetronal
8390:Safranal
8339:obovatol
8335:magnolol
8331:honokiol
8161:Alogabat
8156:AA-29504
8105:Synthane
8065:Nitrogen
8045:Kerosine
8025:Gasoline
8015:Ethylene
7955:Centalun
7950:Butylene
7764:Propofol
7726:U-89843A
7706:TGSC01AA
7676:NS-11394
7641:GBLD-345
7606:CGS-9896
7601:CGS-8216
7585:Zaleplon
7580:Taniplon
7560:Indiplon
7555:Fasiplon
7550:Divaplon
7537:Zolpidem
7440:SAGE-872
7435:SAGE-689
7430:SAGE-516
7425:SAGE-324
7420:SAGE-105
7328:Certain
7271:Capuride
7233:Yangonin
7110:baicalin
7106:Skullcap
7096:Luteolin
7071:Catechin
7066:Baicalin
7056:Apigenin
7028:Tybamate
6815:Quazepam
6810:QH-II-66
6790:Prazepam
6770:Oxazolam
6765:Oxazepam
6565:Etizolam
6520:Diazepam
6500:CP-1414S
6465:Clobazam
6455:Clazolam
6342:Valofane
6297:Talbutal
6287:Sigmodal
6192:Hexethal
6087:Barbital
6067:Alphenal
6057:(-)-DMBB
6003:Propanol
5993:Pentanol
5983:Methanol
5925:Alcohols
5848:instead.
5823:instead.
5734:Blockers
5726:Unsorted
5652:Blockers
5553:Blockers
5530:Chloride
5492:A-317567
5484:Blockers
5433:Benzamil
5420:Blockers
5249:NKTR-171
5244:GDC-0276
5239:Funapide
5234:DSP-2230
5229:AZD-3161
5194:Procaine
5109:Butamben
4957:Ethotoin
4832:Ajmaline
4811:Blockers
4770:Riluzole
4729:Blockers
4627:Blockers
4533:Emakalim
4311:Blockers
4153:Pimozide
4023:Ajmaline
3823:Blockers
3638:Fostedil
3568:Canadine
3538:Phenibut
3498:Baclofen
3447:NP078585
3392:Bepridil
3230:SR-33805
3183:Tiapamil
3143:Emopamil
3123:Anipamil
2858:Blockers
2699:Albutoin
2673:Sultiame
2410:Ethotoin
2244:Diazepam
2229:Clobazam
2097:10220491
2072:15867950
1995:(2010).
1934:(1996).
1861:Medscape
1797:16621450
1748:32636742
1689:26880756
1640:19298256
1591:72918370
1583:19443931
1507:Medscape
1465:24574886
1457:17420403
1419:23557118
1411:16800718
1371:18049722
1315:18590620
1263:11112809
1255:10908292
1117:11831540
1011:endpoint
1003:Phase II
990:Phase II
955:amygdala
951:kindling
852:In vitro
793:tinnitus
765:migraine
761:tinnitus
702:) is an
415:DrugBank
162:ATC code
155:By mouth
8427:borneol
8425:(e.g.,
8417:trional
8407:(e.g.,
8325:(e.g.,
8323:Lignans
8273:(e.g.,
8231:(e.g.,
8176:Bromide
8168:(e.g.,
8151:α-EMTBL
8115:Toluene
8085:Propane
7960:Chloral
7940:Benzene
7920:Acetone
7751:Phenols
7741:Y-23684
7731:U-90042
7716:TPA-023
7701:SX-3228
7686:ROD-188
7671:NS-2710
7666:NS-2664
7651:JM-1232
7636:ELB-139
7631:CTP-354
7517:Alpidem
7116:Wogonin
7091:Linarin
6570:FG-8205
6277:Reposal
5978:Menthol
5938:Butanol
5502:Aspirin
5324:Menthol
5311:Others:
5281:Toxins:
5124:Cocaine
4649:GAL-021
4269:KCNQ (K
4231:KCNQ (K
4048:AZD1305
3986:Sotalol
3981:ShK-186
3961:Notoxin
3648:JTV-519
3628:Fasudil
3357:ProTx I
3337:ABT-639
3324:SNX-482
3195:AH-1058
3192:Others:
2835:Calcium
2592:Others:
2496:Others:
2430:Ureides
2385:Channel
2276:Bromide
2273:Others:
2063:6741764
1884:. U.S.
1788:1562526
1739:7318307
1722:: 895.
1680:4772374
1631:2697739
1362:2096728
1306:2587091
1217:9384239
1125:5568963
1035:by the
963:kainate
953:of the
937:History
848:digoxin
797:vertigo
731:Trobalt
708:partial
612:303.337
571:Formula
424:DB04953
370:PubChem
178:)
172: (
170:N03AX21
135::
117::
93:a612028
8515:Portal
8360:Niacin
7945:Butane
7898:SL-164
7769:Thymol
7711:TP-003
7592:Others
7395:P1-185
7355:5β-DHP
7350:5α-DHP
7345:3α-DHP
7193:Kavain
7101:Rc-OMe
5799:Others
4788:Sodium
4441:Barium
4245:XE-991
4113:E-4031
4063:BeKm-1
4033:AmmTX3
3916:HgeTx1
3906:E-4031
3688:Osthol
3457:TROX-1
3342:ML-218
2762:WHO-EM
2692:Others
2641:Others
2348:Others
2095:
2070:
2060:
1920:(241).
1795:
1785:
1746:
1736:
1687:
1677:
1638:
1628:
1589:
1581:
1463:
1455:
1417:
1409:
1369:
1359:
1313:
1303:
1261:
1253:
1215:
1148:4 June
1123:
1115:
969:, and
929:. The
805:tremor
742:Potiga
645:SMILES
495:ChEMBL
484:D09569
444:108740
384:121892
336:Ethyl
313:Kidney
265:60–80%
231:
218:
205:
130:
120:by INN
113:
8219:DEABL
7912:gases
7721:TP-13
7450:THDOC
7340:DHDOC
5833:LGICs
5540:CaCCs
5512:PcTX1
5471:ASICs
4798:VGSCs
4068:BmTx3
3921:HsTx1
3810:VGKCs
2845:VDCCs
2011:(PDF)
2000:(PDF)
1972:(PDF)
1954:(PDF)
1939:(PDF)
1910:(PDF)
1587:S2CID
1461:S2CID
1415:S2CID
1259:S2CID
1142:(PDF)
1121:S2CID
981:In a
694:) or
665:InChI
621:JSmol
315:(84%)
276:Liver
7522:DS-1
7154:Kava
7081:EGCG
6017:tert
6009:tert
5912:GABA
5846:here
5844:See
5821:here
5819:See
5808:TRPs
5639:CFTR
5566:DIDS
5407:ENaC
5328:mint
4716:K2Ps
4587:GIRK
4432:GIRK
4298:IRKs
4014:hERG
3362:Z944
3288:Z160
2165:PAMs
2158:GABA
2093:PMID
2068:PMID
1793:PMID
1744:PMID
1685:PMID
1636:PMID
1579:PMID
1453:PMID
1407:PMID
1367:PMID
1311:PMID
1251:PMID
1213:PMID
1150:2014
1113:PMID
1058:The
1054:Name
967:NMDA
925:and
873:KCNQ
809:gait
795:and
779:The
767:and
721:and
700:USAN
475:KEGG
455:UNII
404:2601
281:and
245:data
69:AHFS
56:USAN
8251:DS2
7360:DHT
7076:EGC
5070:FBT
4503:ATP
4323:ATP
2140:N03
2058:PMC
2050:doi
1783:PMC
1775:doi
1734:PMC
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