25:
5267:
711:
Tocilizumab seems to be more beneficial, whereas the clinical efficacy of
Sarilumab has not been established as data on decreased mortality was often not significant. The number of trials did not allow for the identification of a specific patient subset that benefits the most from Sarilumab
707:
is 12, meaning for every 12 intensive care unit patients treated 1 additional person survives compared to treatment as normal, also speeding up patients' recovery and reducing the length of time that critically-ill patients need to spend in intensive care by about a week
1274:- Yu SY, Koh DH, Choi M, et al. Clinical efficacy and safety of interleukin-6 receptor antagonists (tocilizumab and sarilumab) in patients with COVID-19: a systematic review and meta-analysis. Emerg Microbes Infect. 2022;11(1):1154-1165. doi:10.1080/22221751.2022.2059405
554:
Sarilumab is used for the treatment of moderately to severely active rheumatoid arthritis in people who have not responded to, or did not tolerate, more conventional treatments. It can be used alone or in combination with
891:
1051:"Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial"
1283:- Sivapalasingam S, Lederer DJ, Bhore R, et al. Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19: A Randomized Clinical Trial . Clin Infect Dis. 2022;ciac153. doi:10.1093/cid/ciac153
246:
1172:
4002:
987:
2937:
571:
In the
European Union, sarilumab is contraindicated in people with active, severe infections. While this is not listed as a contraindication under the US FDA approval, there is a
201:
939:
Boyce EG, Rogan EL, Vyas D, Prasad N, Mai Y (February 2018). "Sarilumab: Review of a Second IL-6 Receptor
Antagonist Indicated for the Treatment of Rheumatoid Arthritis".
480:
899:
5302:
758:
3995:
125:
1495:
2930:
1300:"Sarilumab for Previously-Treated Moderate or Severe Rheumatoid Arthritis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal"
1180:
76:
3988:
2411:
635:
On 15 May 2013, both companies announced that 2 new trials were starting (COMPARE and ASCERTAIN) and the first patients had already been enrolled.
1132:"Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a Phase III Study"
5200:
4467:
2923:
1194:
998:
5204:
5190:
5150:
3946:
1344:"Two years of sarilumab in patients with rheumatoid arthritis and an inadequate response to MTX: safety, efficacy and radiographic outcomes"
5219:
1208:
560:
1237:
5124:
4072:
2354:
1724:
1098:
1488:
812:
2763:
231:
157:
1099:"Sanofi and Regeneron Announce Patient Enrollment in Two Phase 3 Trials with Sarilumab in Rheumatoid Arthritis (RA). May 2013"
5287:
3918:
663:
In July 2019, a multi-center trial was launched to study 'Sarilumab in
Patients With Glucocorticoid-Dependent Sarcoidosis.'
5085:
5064:
3928:
1560:
877:
672:
528:
377:
5292:
3963:
1669:
1481:
676:
176:
5257:
1539:
3512:
2217:
1299:
994:
895:
532:
516:
2597:
5043:
5003:
4982:
4926:
4894:
4853:
4811:
4765:
4684:
4658:
4602:
4561:
4535:
4509:
4163:
3951:
2592:
692:
A study of 420 patients was halted in
September 2020, due to lack of demonstrated effectiveness in treating
619:
607:
187:
4618:
645:
In
November 2015, the SARIL-RA-TARGET trial reported good results (meeting both its coprimary end points).
4478:
4458:
4437:
4356:
4295:
4239:
4193:
4117:
4022:
2397:
1823:
1504:
1130:
Genovese MC, Fleischmann R, Kivitz AJ, Rell-Bakalarska M, Martincova R, Fiore S, et al. (June 2015).
704:
539:
194:
103:
1342:
Genovese MC, van
Adelsberg J, Fan C, Graham NM, van Hoogstraten H, Parrino J, et al. (August 2018).
730:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
3024:
2946:
2584:
4128:
5240:
5023:
4011:
3228:
1473:
729:
524:
323:
4153:
922:"Sanofi and Regeneron Report Positive Phase 2b Trial Results with Sarilumab in Rheumatoid Arthritis"
5014:
4572:
4367:
4143:
4037:
1805:
921:
591:
in patients receiving 200 mg sarilumab every 2 weeks, compared to patients being treated with
579:
infection before treatment and monitoring for signs of an infection during therapy with sarilumab.
505:
341:
86:
69:
4884:
4879:
4864:
4776:
4755:
4204:
4138:
4097:
4041:
4014:
3413:
3372:
3212:
3004:
2754:
1855:
1330:
964:
4745:
4613:
4520:
4499:
4250:
4219:
4214:
4158:
4077:
2794:
2652:
1216:
786:
4791:
4224:
4052:
4047:
2804:
2490:
1931:
4397:
4382:
4346:
4316:
4062:
3304:
2974:
2915:
2759:
2749:
1550:
1508:
1461:
1416:
1373:
1322:
1188:
1153:
1080:
956:
258:
115:
1049:
Burmester GR, Lin Y, Patel R, van
Adelsberg J, Mangan EK, Graham NM, et al. (May 2017).
595:(13.6% vs 0.5%). However, infection rates were similar between both groups (28.8% vs 27.7%).
350:
5235:
3294:
3284:
2555:
2458:
2121:
2017:
1451:
1441:
1406:
1398:
1363:
1355:
1314:
1143:
1070:
1062:
948:
838:
599:
422:
292:
4711:
4707:
4703:
865:
386:
5297:
5271:
5027:
3712:
3488:
2854:
2739:
615:
310:
300:
33:
1105:
42:
Please help update this article to reflect recent events or newly available information.
5225:
5215:
5210:
5196:
5182:
5172:
5167:
5114:
5096:
5075:
5054:
5033:
5019:
4993:
4937:
4905:
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4832:
4827:
4822:
4786:
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4695:
4674:
4628:
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1411:
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1075:
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5281:
4967:
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4489:
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4372:
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4148:
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3867:
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3613:
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3418:
3312:
2958:
2950:
2894:
2824:
2734:
2641:
2427:
2127:
2049:
2001:
1981:
1839:
1755:
1606:
1572:
763:
611:
572:
512:
509:
270:
149:
1334:
1066:
675:(FDA) refused approval for marketing as a treatment for rheumatoid arthritis due to
5141:
4962:
4648:
4643:
4638:
4387:
4326:
4285:
3857:
3842:
3822:
3812:
3791:
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3648:
3633:
3603:
3583:
3578:
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3473:
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3453:
3403:
3398:
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3191:
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3079:
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2510:
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2156:
2132:
2079:
1956:
1946:
1765:
1682:
1677:
1635:
1588:
1545:
1512:
1298:
Bermejo I, Ren S, Simpson E, Clowes M, Scott DL, Young A, et al. (June 2018).
968:
639:
576:
556:
543:
214:
209:
3980:
1359:
1430:"Profile of sarilumab and its potential in the treatment of rheumatoid arthritis"
1030:
135:
4972:
4952:
4915:
4750:
4740:
4592:
4587:
4422:
4392:
4331:
4173:
4133:
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4087:
3923:
3913:
3852:
3837:
3827:
3817:
3796:
3781:
3766:
3761:
3756:
3731:
3684:
3663:
3658:
3653:
3643:
3638:
3623:
3598:
3588:
3568:
3548:
3543:
3508:
3503:
3493:
3483:
3478:
3448:
3438:
3408:
3362:
3357:
3347:
3332:
3317:
3289:
3274:
3259:
3254:
3249:
3217:
3160:
3155:
3145:
3125:
3104:
3099:
3069:
2989:
2899:
2839:
2829:
2819:
2719:
2709:
2699:
2694:
2659:
2570:
2565:
2540:
2530:
2520:
2495:
2480:
2475:
2433:
2403:
2389:
2384:
2370:
2313:
2271:
2266:
2252:
2247:
2233:
2213:
2166:
2142:
2100:
2084:
2055:
2039:
2007:
1991:
1986:
1961:
1911:
1901:
1896:
1891:
1880:
1870:
1775:
1687:
1645:
1630:
1624:
1620:
1567:
703:
and
Sarilumab were added to the UK recommended list for COVID-19 treatment, the
700:
588:
143:
1387:"Efficacy and safety of sarilumab in patients with active rheumatoid arthritis"
4957:
4947:
4842:
4735:
4730:
4551:
4412:
4402:
4336:
4270:
4183:
4178:
4107:
3883:
3862:
3847:
3832:
3776:
3771:
3751:
3746:
3717:
3691:
3628:
3608:
3593:
3573:
3563:
3518:
3468:
3458:
3433:
3428:
3423:
3388:
3383:
3352:
3337:
3279:
3269:
3264:
3244:
3181:
3176:
3165:
3135:
3130:
3074:
3049:
3034:
3019:
3014:
2984:
2889:
2884:
2869:
2809:
2799:
2784:
2779:
2774:
2724:
2714:
2704:
2669:
2647:
2633:
2545:
2535:
2525:
2515:
2500:
2443:
2438:
2417:
2332:
2327:
2285:
2279:
2180:
2137:
2033:
2023:
1976:
1966:
1941:
1936:
1926:
1921:
1916:
1906:
1865:
1850:
1845:
1829:
1770:
1750:
1699:
1659:
1640:
1582:
1318:
679:(GMP) violations. The drug was eventually approved by the FDA on 22 May 2017.
653:
592:
461:
361:
1402:
1250:
952:
4427:
4417:
4280:
3786:
3618:
3443:
3342:
3327:
3186:
3150:
3114:
3109:
3089:
3064:
3059:
3044:
3039:
3009:
2979:
2879:
2874:
2834:
2789:
2769:
2729:
2664:
2628:
2550:
2346:
2299:
2228:
2194:
2161:
1971:
1860:
1760:
1600:
1025:
129:
1465:
1420:
1377:
1326:
1157:
1084:
960:
866:"Statement On A Nonproprietary Name Adopted By The USAN Council: Sarilumab"
928:(Press release). Paris & Tarrytown, New York: Regeneron. 12 July 2011.
598:
Other common side effects that occurred in 1% to 10% of patients included
62:
32:
Parts of this article (those related to lack of effectiveness against the
4067:
3196:
3119:
3029:
2999:
2814:
2689:
2378:
1886:
1796:
1732:
1654:
1446:
693:
603:
316:
171:
5186:
4669:
3673:
3558:
2307:
1428:
Raimondo MG, Biggioggero M, Crotti C, Becciolini A, Favalli EG (2017).
542:
has been suspended after the drug failed to show clinical benefit over
98:
1148:
1131:
4801:
3898:
2622:
2453:
520:
1238:
Sanofi halts tests of arthritis drug for use as a COVID-19 treatment
406:
5108:
5104:
5100:
4719:
4715:
4699:
2321:
2174:
657:
91:
2293:
2241:
2202:
2188:
1742:
1616:
587:
The MONARCH trial suggested a significantly higher incidence of
397:
279:
3984:
2919:
1477:
699:
On 7 January 2021, following results from the REMAP-CAP trial,
264:
166:
5176:
2150:
737:
18:
240:
1173:"Sarilumab effective in broad range of RA patients: Study"
642:) for RA reported meeting its three coprimary endpoints.
253:
656:(an anti-TNF) found sarilumab superior at reducing the
487:
5255:
5160:
5140:
5133:
5084:
5063:
5042:
5002:
4981:
4925:
4893:
4852:
4810:
4764:
4683:
4657:
4601:
4560:
4534:
4508:
4477:
4457:
4436:
4355:
4294:
4238:
4192:
4116:
4021:
3906:
3896:
3876:
3805:
3739:
3730:
3699:
3371:
3303:
3237:
2966:
2957:
2682:
2610:
2583:
2468:
2111:
1813:
1804:
1795:
1788:
1741:
1723:
1714:
1668:
1599:
1529:
1520:
460:
421:
416:
396:
376:
360:
340:
335:
322:
309:
299:
291:
230:
225:
200:
186:
156:
142:
124:
114:
109:
97:
85:
75:
68:
864:
1391:Therapeutic Advances in Musculoskeletal Disease
660:-ESR score in patients with RA after 24 weeks.
349:
1044:
1042:
1040:
3996:
2931:
1489:
1251:"Two more life-saving Covid drugs discovered"
8:
1021:
1019:
175:
61:
5137:
4003:
3989:
3981:
3903:
3736:
2963:
2938:
2924:
2916:
1810:
1801:
1792:
1720:
1526:
1496:
1482:
1474:
1455:
1445:
1410:
1367:
1147:
1074:
787:"Regulatory Decision Summary for Kevzara"
385:
5168:Interleukin 14 (taxilin alpha, HMW-BCGF)
813:"Kevzara- sarilumab injection, solution"
523:developed the drug for the treatment of
5262:
982:
980:
978:
721:
652:phase III trial comparing sarilimab to
148:
4466:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
1186:
638:In June 2015, a phase III trial (with
60:
5303:Disease-modifying antirheumatic drugs
1029:
988:"Kevzara: EPAR – Product Information"
561:disease-modifying antirheumatic drugs
134:
7:
1434:Drug Design, Development and Therapy
1385:McCarty D, Robinson A (March 2018).
213:
16:Human monoclonal antibody medication
997:. 26 September 2017. Archived from
575:that recommends testing for hidden
405:
1193:: CS1 maint: overridden setting (
14:
331:21 days (steady-state, estimated)
5265:
1055:Annals of the Rheumatic Diseases
892:"Kevzara: Authorisation details"
439:
433:
23:
4994:Interleukin 27 (interleukin 30)
1067:10.1136/annrheumdis-2016-210310
843:European Medicines Agency (EMA)
791:Drug and Health Products Portal
527:(RA), for which it received US
451:
445:
427:
1:
1561:dihydroorotate dehydrogenase
1249:Roberts M (7 January 2021).
1136:Arthritis & Rheumatology
1034:. Accessed 29 November 2017.
878:American Medical Association
673:Food and Drug Administration
531:approval on 22 May 2017 and
500:, sold under the brand name
4344:Antisense oligonucleotides:
1540:purine synthesis inhibitors
1360:10.1093/rheumatology/key121
712:treatment, yet (May 2022).
677:good manufacturing practice
5319:
671:In October 2016, the U.S.
606:count), infections of the
535:approval on 23 June 2017.
417:Chemical and physical data
3941:
1725:IL-1 receptor antagonists
1319:10.1007/s40273-018-0677-7
995:European Medicines Agency
941:Annals of Pharmacotherapy
896:European Medicines Agency
622:such as pain or redness.
533:European Medicines Agency
517:Regeneron Pharmaceuticals
477:
2598:Anti-lymphocyte globulin
1403:10.1177/1759720X17752037
953:10.1177/1060028018761599
620:injection site reactions
5034:Interleukin-29 (IFN-λ1)
4179:Daclizumab (dacliximab)
4164:Tucotuzumab celmoleukin
2593:Anti-thymocyte globulin
1505:Immunosuppressive drugs
608:upper respiratory tract
508:medication against the
5015:Interferon λ4 (IFN-λ4)
4108:Rilonacept (IL-1 Trap)
2398:Interleukin-6 receptor
1824:Complement component 5
705:number needed to treat
648:In November 2016, the
540:ankylosing spondylitis
5288:Monoclonal antibodies
4938:Interleukin 23 (SGRF)
4619:Cintredekin besudotox
4547:Interleukin 11 (AGIF)
4526:Interleukin 10 (CSIF)
3025:Camidanlumab tesirine
2947:Monoclonal antibodies
546:in a phase II trial.
4012:Interleukin receptor
3700:Chimeric + humanized
3229:Nivolumab/relatlimab
1447:10.2147/DDDT.S100302
1183:on 21 November 2015.
902:on 27 September 2017
631:Rheumatoid arthritis
525:rheumatoid arthritis
4144:Denileukin diftitox
1213:Sarcoidosis Program
506:monoclonal antibody
249:(Prescription only)
70:Monoclonal antibody
65:
5293:Immunosuppressants
4716:E (interleukin 25)
3968:Never to phase III
3414:Certolizumab pegol
3381:Immunosuppressive:
2755:Diroximel fumarate
2428:IL-2 receptor/CD25
1856:Certolizumab pegol
1509:Immunosuppressants
1209:"More Information"
1111:on 19 January 2017
5253:
5252:
5249:
5248:
5218:(signals through
5199:(signals through
5185:(signals through
5175:(signals through
4799:Binding proteins:
4129:Adargileukin alfa
3978:
3977:
3937:
3936:
3892:
3891:
3726:
3725:
3681:Immune activation
3173:Immune activation
2975:Immunosuppression
2913:
2912:
2760:Efgartigimod alfa
2750:Dimethyl fumarate
2678:
2677:
2606:
2605:
2579:
2578:
1784:
1783:
1710:
1709:
1551:Mycophenolic acid
1313:(12): 1427–1437.
1307:PharmacoEconomics
1149:10.1002/art.39093
793:. 12 January 2017
567:Contraindications
495:
494:
283:
268:
256:
244:
169:
57:
56:
5310:
5270:
5269:
5268:
5261:
5241:Efineptakin alfa
5236:Efavaleukin alfa
5138:
4105:Decoy receptors:
4005:
3998:
3991:
3982:
3904:
3737:
3295:Zolimomab aritox
3285:Telimomab aritox
2964:
2940:
2933:
2926:
2917:
2556:Telimomab aritox
2459:Zolimomab aritox
2280:CD62L/L-selectin
2018:Immunoglobulin E
1811:
1802:
1793:
1721:
1527:
1498:
1491:
1484:
1475:
1469:
1459:
1449:
1424:
1414:
1381:
1371:
1354:(8): 1423–1431.
1338:
1304:
1284:
1281:
1275:
1272:
1266:
1265:
1263:
1261:
1246:
1240:
1235:
1229:
1228:
1226:
1224:
1219:on 9 August 2019
1215:. Archived from
1205:
1199:
1198:
1192:
1184:
1179:. Archived from
1168:
1162:
1161:
1151:
1127:
1121:
1120:
1118:
1116:
1110:
1104:. Archived from
1103:
1095:
1089:
1088:
1078:
1046:
1035:
1033:
1023:
1014:
1013:
1011:
1009:
1003:
992:
984:
973:
972:
936:
930:
929:
918:
912:
911:
909:
907:
898:. Archived from
888:
882:
881:
871:
868:
861:
855:
854:
852:
850:
835:
829:
828:
826:
824:
809:
803:
802:
800:
798:
783:
777:
776:
774:
772:
755:
749:
748:
746:
744:
734:nctr-crs.fda.gov
726:
600:thrombocytopenia
491:
490:
483:
472:
470:
453:
447:
441:
435:
429:
409:
389:
353:
327:
281:
278:
273:
266:
263:
255:
252:
242:
239:
217:
179:
168:
165:
152:
138:
66:
64:
52:
49:
43:
27:
26:
19:
5318:
5317:
5313:
5312:
5311:
5309:
5308:
5307:
5278:
5277:
5276:
5266:
5264:
5256:
5254:
5245:
5156:
5129:
5080:
5059:
5038:
4998:
4977:
4921:
4918:(against IL-22)
4889:
4848:
4845:(against IL-20)
4806:
4760:
4679:
4653:
4597:
4556:
4530:
4504:
4473:
4453:
4432:
4351:
4290:
4234:
4188:
4112:
4017:
4009:
3979:
3974:
3973:
3958:Clinical trials
3933:
3888:
3872:
3801:
3722:
3713:Rozanolixizumab
3701:
3695:
3687:
3676:
3489:Lulizumab pegol
3367:
3299:
3233:
2953:
2944:
2914:
2909:
2855:Rozanolixizumab
2740:Deucravacitinib
2674:
2602:
2575:
2464:
2113:
2107:
1815:
1780:
1737:
1716:
1706:
1664:
1604:
1595:
1531:Antimetabolites
1522:
1516:
1502:
1472:
1427:
1384:
1341:
1302:
1297:
1293:
1291:Further reading
1288:
1287:
1282:
1278:
1273:
1269:
1259:
1257:
1248:
1247:
1243:
1236:
1232:
1222:
1220:
1207:
1206:
1202:
1185:
1177:Formulary Watch
1170:
1169:
1165:
1129:
1128:
1124:
1114:
1112:
1108:
1101:
1097:
1096:
1092:
1048:
1047:
1038:
1024:
1017:
1007:
1005:
1004:on 18 June 2018
1001:
990:
986:
985:
976:
938:
937:
933:
920:
919:
915:
905:
903:
890:
889:
885:
869:
863:
862:
858:
848:
846:
837:
836:
832:
822:
820:
811:
810:
806:
796:
794:
785:
784:
780:
770:
768:
757:
756:
752:
742:
740:
728:
727:
723:
718:
690:
685:
669:
633:
628:
626:Clinical trials
616:hyperlipidaemia
614:, oral herpes,
585:
569:
552:
538:Development in
486:
484:
481:(what is this?)
478:
468:
466:
456:
450:
444:
438:
432:
412:
392:
372:
356:
325:
301:Bioavailability
293:Pharmacokinetic
287:
271:
221:
189:
182:
53:
47:
44:
41:
34:Omicron variant
28:
24:
17:
12:
11:
5:
5316:
5314:
5306:
5305:
5300:
5295:
5290:
5280:
5279:
5275:
5274:
5251:
5250:
5247:
5246:
5244:
5243:
5238:
5229:
5228:
5226:Interleukin 35
5223:
5216:Interleukin 34
5213:
5211:Interleukin 32
5208:
5197:Interleukin 26
5194:
5183:Interleukin 24
5180:
5173:Interleukin 16
5170:
5164:
5162:
5158:
5157:
5155:
5154:
5146:
5144:
5135:
5131:
5130:
5128:
5127:
5118:
5117:
5115:Interleukin 38
5112:
5097:Interleukin 36
5090:
5088:
5082:
5081:
5079:
5078:
5076:Interleukin 33
5069:
5067:
5061:
5060:
5058:
5057:
5055:Interleukin 31
5048:
5046:
5040:
5039:
5037:
5036:
5031:
5020:Interleukin 28
5017:
5008:
5006:
5000:
4999:
4997:
4996:
4987:
4985:
4979:
4978:
4976:
4975:
4970:
4965:
4960:
4955:
4950:
4941:
4940:
4931:
4929:
4923:
4922:
4920:
4919:
4909:
4908:
4906:Interleukin 22
4899:
4897:
4891:
4890:
4888:
4887:
4882:
4873:
4872:
4870:Interleukin 21
4867:
4858:
4856:
4850:
4849:
4847:
4846:
4836:
4835:
4833:Interleukin 24
4830:
4828:Interleukin 20
4825:
4823:Interleukin 19
4816:
4814:
4808:
4807:
4805:
4804:
4795:
4794:
4789:
4787:Interleukin 37
4784:
4782:Interleukin 18
4779:
4770:
4768:
4762:
4761:
4759:
4758:
4753:
4748:
4743:
4738:
4733:
4724:
4723:
4696:Interleukin 17
4689:
4687:
4681:
4680:
4678:
4677:
4675:Interleukin 15
4672:
4663:
4661:
4655:
4654:
4652:
4651:
4646:
4641:
4632:
4631:
4629:Interleukin 13
4626:
4621:
4616:
4607:
4605:
4599:
4598:
4596:
4595:
4590:
4581:
4580:
4578:Interleukin 12
4575:
4566:
4564:
4558:
4557:
4555:
4554:
4549:
4540:
4538:
4532:
4531:
4529:
4528:
4523:
4514:
4512:
4506:
4505:
4503:
4502:
4493:
4492:
4483:
4481:
4475:
4474:
4472:
4471:
4463:
4461:
4455:
4454:
4452:
4451:
4442:
4440:
4434:
4433:
4431:
4430:
4425:
4420:
4415:
4410:
4405:
4400:
4395:
4390:
4385:
4376:
4375:
4370:
4361:
4359:
4353:
4352:
4350:
4349:
4340:
4339:
4334:
4329:
4320:
4319:
4310:
4309:
4300:
4298:
4292:
4291:
4289:
4288:
4283:
4274:
4273:
4264:
4263:
4261:Interleukin 13
4258:
4253:
4244:
4242:
4236:
4235:
4233:
4232:
4230:Promegapoietin
4227:
4222:
4217:
4212:
4207:
4198:
4196:
4190:
4189:
4187:
4186:
4181:
4176:
4167:
4166:
4161:
4156:
4154:Pegaldesleukin
4151:
4146:
4141:
4136:
4131:
4122:
4120:
4114:
4113:
4111:
4110:
4101:
4100:
4095:
4090:
4081:
4080:
4075:
4070:
4065:
4056:
4055:
4050:
4045:
4027:
4025:
4019:
4018:
4010:
4008:
4007:
4000:
3993:
3985:
3976:
3975:
3972:
3971:
3970:
3969:
3966:
3955:
3949:
3943:
3942:
3939:
3938:
3935:
3934:
3932:
3931:
3926:
3921:
3916:
3910:
3908:
3901:
3894:
3893:
3890:
3889:
3887:
3886:
3880:
3878:
3874:
3873:
3871:
3870:
3865:
3860:
3855:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3809:
3807:
3803:
3802:
3800:
3799:
3794:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3743:
3741:
3734:
3728:
3727:
3724:
3723:
3721:
3720:
3715:
3710:
3704:
3702:
3697:
3696:
3678:
3677:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3636:
3631:
3626:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3536:
3531:
3526:
3521:
3516:
3513:+hyaluronidase
3506:
3501:
3496:
3491:
3486:
3481:
3476:
3471:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3396:
3391:
3386:
3377:
3375:
3369:
3368:
3366:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3309:
3307:
3301:
3300:
3298:
3297:
3292:
3287:
3282:
3277:
3272:
3267:
3262:
3257:
3252:
3247:
3241:
3239:
3235:
3234:
3232:
3231:
3221:
3220:
3215:
3210:
3200:
3199:
3194:
3189:
3184:
3179:
3169:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3117:
3112:
3107:
3102:
3097:
3092:
3087:
3082:
3077:
3072:
3067:
3062:
3057:
3052:
3047:
3042:
3037:
3032:
3027:
3022:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2982:
2970:
2968:
2961:
2955:
2954:
2945:
2943:
2942:
2935:
2928:
2920:
2911:
2910:
2908:
2907:
2902:
2897:
2892:
2887:
2882:
2877:
2872:
2867:
2862:
2857:
2852:
2847:
2842:
2837:
2832:
2827:
2822:
2817:
2812:
2807:
2802:
2797:
2792:
2787:
2782:
2777:
2772:
2767:
2764:+hyaluronidase
2757:
2752:
2747:
2745:Deuruxolitinib
2742:
2737:
2732:
2727:
2722:
2717:
2712:
2707:
2702:
2697:
2692:
2686:
2684:
2680:
2679:
2676:
2675:
2673:
2672:
2667:
2662:
2657:
2656:
2655:
2650:
2638:
2637:
2636:
2631:
2618:
2616:
2608:
2607:
2604:
2603:
2601:
2600:
2595:
2589:
2587:
2581:
2580:
2577:
2576:
2574:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2538:
2533:
2528:
2523:
2518:
2513:
2508:
2503:
2498:
2493:
2488:
2483:
2478:
2472:
2470:
2466:
2465:
2463:
2462:
2449:
2448:
2447:
2446:
2441:
2436:
2423:
2422:
2421:
2420:
2408:
2407:
2406:
2394:
2393:
2392:
2387:
2375:
2374:
2373:
2368:
2363:
2351:
2350:
2349:
2338:
2337:
2336:
2335:
2330:
2318:
2317:
2316:
2304:
2303:
2302:
2290:
2289:
2288:
2276:
2275:
2274:
2269:
2257:
2256:
2255:
2250:
2238:
2237:
2236:
2231:
2226:
2221:
2218:+hyaluronidase
2211:
2199:
2198:
2197:
2185:
2184:
2183:
2171:
2170:
2169:
2164:
2159:
2147:
2146:
2145:
2140:
2135:
2130:
2117:
2115:
2109:
2108:
2106:
2105:
2104:
2103:
2090:
2089:
2088:
2087:
2082:
2061:
2060:
2059:
2058:
2045:
2044:
2043:
2042:
2029:
2028:
2027:
2026:
2013:
2012:
2011:
2010:
1997:
1996:
1995:
1994:
1989:
1984:
1979:
1974:
1969:
1964:
1959:
1954:
1949:
1944:
1939:
1934:
1929:
1924:
1919:
1914:
1909:
1904:
1899:
1894:
1889:
1876:
1875:
1874:
1873:
1868:
1863:
1858:
1853:
1848:
1835:
1834:
1833:
1832:
1819:
1817:
1808:
1799:
1790:
1786:
1785:
1782:
1781:
1779:
1778:
1773:
1768:
1763:
1758:
1753:
1747:
1745:
1739:
1738:
1736:
1735:
1729:
1727:
1718:
1712:
1711:
1708:
1707:
1705:
1704:
1703:
1702:
1694:PDE4 inhibitor
1690:
1685:
1680:
1674:
1672:
1666:
1665:
1663:
1662:
1657:
1651:
1650:
1649:
1648:
1643:
1638:
1633:
1612:
1610:
1597:
1596:
1594:
1593:
1592:
1591:
1578:
1577:
1576:
1575:
1570:
1556:
1555:
1554:
1553:
1548:
1535:
1533:
1524:
1518:
1517:
1503:
1501:
1500:
1493:
1486:
1478:
1471:
1470:
1425:
1382:
1339:
1294:
1292:
1289:
1286:
1285:
1276:
1267:
1241:
1230:
1200:
1163:
1142:(6): 1424–37.
1122:
1090:
1061:(5): 840–847.
1036:
1015:
974:
947:(8): 780–791.
931:
913:
883:
856:
845:. 23 June 2017
839:"Kevzara EPAR"
830:
819:. 17 June 2024
804:
778:
750:
720:
719:
717:
714:
689:
686:
684:
681:
668:
665:
632:
629:
627:
624:
584:
581:
568:
565:
551:
548:
493:
492:
475:
474:
464:
458:
457:
454:
448:
442:
436:
430:
425:
419:
418:
414:
413:
411:
410:
402:
400:
394:
393:
391:
390:
382:
380:
374:
373:
371:
370:
366:
364:
358:
357:
355:
354:
346:
344:
338:
337:
333:
332:
329:
320:
319:
313:
307:
306:
303:
297:
296:
289:
288:
286:
285:
276:
261:
250:
236:
234:
228:
227:
223:
222:
220:
219:
206:
204:
198:
197:
192:
190:administration
184:
183:
181:
180:
162:
160:
154:
153:
146:
140:
139:
132:
122:
121:
118:
112:
111:
107:
106:
101:
95:
94:
89:
83:
82:
81:Whole antibody
79:
73:
72:
55:
54:
31:
29:
22:
15:
13:
10:
9:
6:
4:
3:
2:
5315:
5304:
5301:
5299:
5296:
5294:
5291:
5289:
5286:
5285:
5283:
5273:
5263:
5259:
5242:
5239:
5237:
5234:
5231:
5230:
5227:
5224:
5221:
5217:
5214:
5212:
5209:
5206:
5202:
5198:
5195:
5192:
5188:
5184:
5181:
5178:
5174:
5171:
5169:
5166:
5165:
5163:
5159:
5152:
5148:
5147:
5145:
5143:
5139:
5136:
5132:
5126:
5123:
5120:
5119:
5116:
5113:
5110:
5106:
5102:
5098:
5095:
5092:
5091:
5089:
5087:
5083:
5077:
5074:
5071:
5070:
5068:
5066:
5062:
5056:
5053:
5050:
5049:
5047:
5045:
5041:
5035:
5032:
5029:
5025:
5021:
5018:
5016:
5013:
5010:
5009:
5007:
5005:
5001:
4995:
4992:
4989:
4988:
4986:
4984:
4980:
4974:
4971:
4969:
4968:Tildrakizumab
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4943:
4942:
4939:
4936:
4933:
4932:
4930:
4928:
4924:
4917:
4914:
4911:
4910:
4907:
4904:
4901:
4900:
4898:
4896:
4892:
4886:
4883:
4881:
4878:
4875:
4874:
4871:
4868:
4866:
4863:
4860:
4859:
4857:
4855:
4851:
4844:
4841:
4838:
4837:
4834:
4831:
4829:
4826:
4824:
4821:
4818:
4817:
4815:
4813:
4809:
4803:
4800:
4797:
4796:
4793:
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4772:
4771:
4769:
4767:
4763:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4726:
4725:
4721:
4717:
4713:
4709:
4705:
4701:
4697:
4694:
4691:
4690:
4688:
4686:
4682:
4676:
4673:
4671:
4668:
4665:
4664:
4662:
4660:
4656:
4650:
4647:
4645:
4642:
4640:
4637:
4634:
4633:
4630:
4627:
4625:
4624:Interleukin 4
4622:
4620:
4617:
4615:
4612:
4609:
4608:
4606:
4604:
4600:
4594:
4591:
4589:
4586:
4583:
4582:
4579:
4576:
4574:
4573:Edodekin alfa
4571:
4568:
4567:
4565:
4563:
4559:
4553:
4550:
4548:
4545:
4542:
4541:
4539:
4537:
4533:
4527:
4524:
4522:
4519:
4516:
4515:
4513:
4511:
4507:
4501:
4498:
4495:
4494:
4491:
4490:Interleukin 9
4488:
4485:
4484:
4482:
4480:
4476:
4469:
4465:
4464:
4462:
4460:
4456:
4450:
4449:Interleukin 7
4447:
4444:
4443:
4441:
4439:
4435:
4429:
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4378:
4377:
4374:
4373:Interleukin 6
4371:
4369:
4368:Atexakin alfa
4366:
4363:
4362:
4360:
4358:
4354:
4348:
4345:
4342:
4341:
4338:
4335:
4333:
4330:
4328:
4325:
4322:
4321:
4318:
4315:
4312:
4311:
4308:
4307:Interleukin 5
4305:
4302:
4301:
4299:
4297:
4293:
4287:
4284:
4282:
4279:
4276:
4275:
4272:
4269:
4266:
4265:
4262:
4259:
4257:
4256:Interleukin 4
4254:
4252:
4249:
4246:
4245:
4243:
4241:
4237:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4210:Interleukin 3
4208:
4206:
4203:
4200:
4199:
4197:
4195:
4191:
4185:
4182:
4180:
4177:
4175:
4172:
4169:
4168:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4149:Interleukin 2
4147:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4124:
4123:
4121:
4119:
4115:
4109:
4106:
4103:
4102:
4099:
4096:
4094:
4091:
4089:
4086:
4083:
4082:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4058:
4057:
4054:
4051:
4049:
4046:
4043:
4039:
4035:
4034:Interleukin 1
4032:
4029:
4028:
4026:
4024:
4020:
4016:
4013:
4006:
4001:
3999:
3994:
3992:
3987:
3986:
3983:
3967:
3965:
3962:
3961:
3959:
3956:
3953:
3950:
3948:
3945:
3944:
3940:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3911:
3909:
3905:
3902:
3900:
3897:Inflammatory
3895:
3885:
3882:
3881:
3879:
3875:
3869:
3868:Tildrakizumab
3866:
3864:
3861:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3810:
3808:
3804:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3744:
3742:
3738:
3735:
3733:
3729:
3719:
3716:
3714:
3711:
3709:
3706:
3705:
3703:
3698:
3694:
3693:
3690:
3686:
3682:
3675:
3672:
3670:
3669:Vobarilizumab
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3614:Spartalizumab
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3539:Pembrolizumab
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3514:
3510:
3507:
3505:
3502:
3500:
3499:Mogamulizumab
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3419:Crizanlizumab
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3379:
3378:
3376:
3374:
3370:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3313:Andecaliximab
3311:
3310:
3308:
3306:
3302:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3263:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3242:
3240:
3236:
3230:
3226:
3223:
3222:
3219:
3216:
3214:
3211:
3209:
3205:
3202:
3201:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3174:
3171:
3170:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3121:
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3101:
3098:
3096:
3093:
3091:
3088:
3086:
3083:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2977:
2976:
2972:
2971:
2969:
2965:
2962:
2960:
2959:Immune system
2956:
2952:
2951:immune system
2948:
2941:
2936:
2934:
2929:
2927:
2922:
2921:
2918:
2906:
2903:
2901:
2898:
2896:
2895:Tildrakizumab
2893:
2891:
2888:
2886:
2883:
2881:
2878:
2876:
2873:
2871:
2868:
2866:
2863:
2861:
2858:
2856:
2853:
2851:
2848:
2846:
2843:
2841:
2838:
2836:
2833:
2831:
2828:
2826:
2825:Pegcetacoplan
2823:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2765:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2735:Darvadstrocel
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2701:
2698:
2696:
2693:
2691:
2688:
2687:
2685:
2681:
2671:
2668:
2666:
2663:
2661:
2658:
2654:
2651:
2649:
2646:
2645:
2644:
2643:
2642:TNF inhibitor
2639:
2635:
2632:
2630:
2627:
2626:
2625:
2624:
2620:
2619:
2617:
2614:
2609:
2599:
2596:
2594:
2591:
2590:
2588:
2586:
2582:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2532:
2529:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2473:
2471:
2467:
2460:
2456:
2455:
2451:
2450:
2445:
2442:
2440:
2437:
2435:
2432:
2431:
2430:
2429:
2425:
2424:
2419:
2416:
2415:
2414:
2413:
2409:
2405:
2402:
2401:
2400:
2399:
2395:
2391:
2388:
2386:
2383:
2382:
2381:
2380:
2376:
2372:
2369:
2367:
2364:
2362:
2359:
2358:
2357:
2356:
2352:
2348:
2345:
2344:
2343:
2340:
2339:
2334:
2331:
2329:
2326:
2325:
2324:
2323:
2319:
2315:
2312:
2311:
2310:
2309:
2308:CD147/Basigin
2305:
2301:
2298:
2297:
2296:
2295:
2291:
2287:
2284:
2283:
2282:
2281:
2277:
2273:
2270:
2268:
2265:
2264:
2263:
2262:
2258:
2254:
2251:
2249:
2246:
2245:
2244:
2243:
2239:
2235:
2232:
2230:
2227:
2225:
2222:
2219:
2215:
2212:
2210:
2207:
2206:
2205:
2204:
2200:
2196:
2193:
2192:
2191:
2190:
2186:
2182:
2179:
2178:
2177:
2176:
2172:
2168:
2165:
2163:
2160:
2158:
2155:
2154:
2153:
2152:
2148:
2144:
2141:
2139:
2136:
2134:
2131:
2129:
2128:Muromonab-CD3
2126:
2125:
2124:
2123:
2119:
2118:
2116:
2110:
2102:
2099:
2098:
2097:
2096:
2092:
2091:
2086:
2083:
2081:
2078:
2077:
2076:
2075:
2071:
2067:
2063:
2062:
2057:
2054:
2053:
2052:
2051:
2047:
2046:
2041:
2038:
2037:
2036:
2035:
2031:
2030:
2025:
2022:
2021:
2020:
2019:
2015:
2014:
2009:
2006:
2005:
2004:
2003:
2002:Interleukin 5
1999:
1998:
1993:
1990:
1988:
1985:
1983:
1982:Tildrakizumab
1980:
1978:
1975:
1973:
1970:
1968:
1965:
1963:
1960:
1958:
1955:
1953:
1950:
1948:
1945:
1943:
1940:
1938:
1935:
1933:
1930:
1928:
1925:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1900:
1898:
1895:
1893:
1890:
1888:
1885:
1884:
1883:
1882:
1878:
1877:
1872:
1869:
1867:
1864:
1862:
1859:
1857:
1854:
1852:
1849:
1847:
1844:
1843:
1842:
1841:
1837:
1836:
1831:
1828:
1827:
1826:
1825:
1821:
1820:
1818:
1816:(noncellular)
1812:
1809:
1807:
1803:
1800:
1798:
1794:
1791:
1789:Extracellular
1787:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1757:
1756:Ridaforolimus
1754:
1752:
1749:
1748:
1746:
1744:
1740:
1734:
1731:
1730:
1728:
1726:
1722:
1719:
1715:Intracellular
1713:
1701:
1698:
1697:
1696:
1695:
1691:
1689:
1686:
1684:
1681:
1679:
1676:
1675:
1673:
1671:
1667:
1661:
1658:
1656:
1653:
1652:
1647:
1644:
1642:
1639:
1637:
1634:
1632:
1629:
1628:
1627:
1626:
1622:
1618:
1614:
1613:
1611:
1608:
1602:
1598:
1590:
1587:
1586:
1585:
1584:
1580:
1579:
1574:
1573:Teriflunomide
1571:
1569:
1566:
1565:
1563:
1562:
1558:
1557:
1552:
1549:
1547:
1544:
1543:
1542:
1541:
1537:
1536:
1534:
1532:
1528:
1525:
1521:Intracellular
1519:
1514:
1510:
1506:
1499:
1494:
1492:
1487:
1485:
1480:
1479:
1476:
1467:
1463:
1458:
1453:
1448:
1443:
1440:: 1593–1603.
1439:
1435:
1431:
1426:
1422:
1418:
1413:
1408:
1404:
1400:
1396:
1392:
1388:
1383:
1379:
1375:
1370:
1365:
1361:
1357:
1353:
1349:
1345:
1340:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1301:
1296:
1295:
1290:
1280:
1277:
1271:
1268:
1256:
1252:
1245:
1242:
1239:
1234:
1231:
1218:
1214:
1210:
1204:
1201:
1196:
1190:
1182:
1178:
1174:
1167:
1164:
1159:
1155:
1150:
1145:
1141:
1137:
1133:
1126:
1123:
1107:
1100:
1094:
1091:
1086:
1082:
1077:
1072:
1068:
1064:
1060:
1056:
1052:
1045:
1043:
1041:
1037:
1032:
1027:
1022:
1020:
1016:
1000:
996:
989:
983:
981:
979:
975:
970:
966:
962:
958:
954:
950:
946:
942:
935:
932:
927:
926:regeneron.com
923:
917:
914:
901:
897:
893:
887:
884:
879:
875:
867:
860:
857:
844:
840:
834:
831:
818:
814:
808:
805:
792:
788:
782:
779:
766:
765:
764:Health Canada
760:
754:
751:
739:
735:
731:
725:
722:
715:
713:
709:
706:
702:
697:
695:
687:
682:
680:
678:
674:
666:
664:
661:
659:
655:
651:
646:
643:
641:
636:
630:
625:
623:
621:
617:
613:
612:urinary tract
609:
605:
601:
596:
594:
590:
582:
580:
578:
574:
573:boxed warning
566:
564:
562:
558:
549:
547:
545:
541:
536:
534:
530:
526:
522:
518:
514:
511:
510:interleukin-6
507:
504:, is a human
503:
499:
489:
482:
476:
465:
463:
459:
426:
424:
420:
415:
408:
404:
403:
401:
399:
395:
388:
384:
383:
381:
379:
375:
368:
367:
365:
363:
359:
352:
348:
347:
345:
343:
339:
334:
330:
328:
321:
318:
314:
312:
308:
304:
302:
298:
294:
290:
284: Rx-only
277:
274:
262:
260:
251:
248:
238:
237:
235:
233:
229:
224:
216:
211:
208:
207:
205:
203:
199:
196:
193:
191:
185:
178:
173:
164:
163:
161:
159:
155:
151:
147:
145:
141:
137:
133:
131:
127:
123:
119:
117:
113:
110:Clinical data
108:
105:
102:
100:
96:
93:
90:
88:
84:
80:
78:
74:
71:
67:
59:
51:
39:
36:) need to be
35:
30:
21:
20:
5232:
5220:M-CSFR/CSF1R
5207:heterodimer)
5193:heterodimer)
5122:Antagonists:
5121:
5093:
5072:
5051:
5011:
4990:
4963:Risankizumab
4944:
4934:
4912:
4902:
4885:NNC0114-0006
4880:NNC0114-0005
4876:
4861:
4839:
4819:
4798:
4773:
4727:
4692:
4666:
4649:Tralokinumab
4644:Lebrikizumab
4639:Anrukinzumab
4635:
4610:
4584:
4569:
4543:
4517:
4496:
4486:
4445:
4407:
4388:Clazakizumab
4379:
4364:
4343:
4327:Benralizumab
4323:
4314:Antagonists:
4313:
4303:
4286:Pascolizumab
4277:
4268:Antagonists:
4267:
4247:
4201:
4170:
4125:
4104:
4084:
4060:Antagonists:
4059:
4030:
3858:Risankizumab
3843:Lebrikizumab
3823:Clazakizumab
3813:Anrukinzumab
3792:Tralokinumab
3708:Otelixizumab
3688:
3680:
3679:
3649:Tregalizumab
3634:Tislelizumab
3604:Satralizumab
3584:Rontalizumab
3579:Retifanlimab
3554:Plozalizumab
3534:Pateclizumab
3529:Pascolizumab
3524:Ozoralizumab
3474:Lampalizumab
3464:Inebilizumab
3454:Fontolizumab
3404:Camrelizumab
3399:Benralizumab
3394:Atezolizumab
3380:
3323:Clenoliximab
3224:
3208:Bertilimumab
3203:
3192:Tremelimumab
3172:
3140:
3095:Mavrilimumab
3085:Lirentelimab
3080:Lerdelimumab
3055:Fresolimumab
2995:Atorolimumab
2973:
2905:Upadacitinib
2865:Satralizumab
2859:
2850:Ritlecitinib
2845:Risankizumab
2640:
2621:
2561:Teprotumumab
2511:Inebilizumab
2506:Fontolizumab
2486:Atorolimumab
2454:T-lymphocyte
2452:
2426:
2410:
2396:
2377:
2366:Lerdelimumab
2361:Bertilimumab
2353:
2341:
2320:
2306:
2292:
2278:
2259:
2240:
2224:Pascolizumab
2209:Obinutuzumab
2201:
2187:
2173:
2157:Clenoliximab
2149:
2133:Otelixizumab
2120:
2093:
2080:Lebrikizumab
2064:
2048:
2032:
2016:
2000:
1957:Satralizumab
1951:
1947:Risankizumab
1879:
1838:
1822:
1814:Serum target
1766:Temsirolimus
1692:
1683:Pomalidomide
1678:Lenalidomide
1636:Pimecrolimus
1615:
1589:Methotrexate
1581:
1559:
1546:Azathioprine
1538:
1523:(initiation)
1437:
1433:
1397:(3): 61–67.
1394:
1390:
1351:
1348:Rheumatology
1347:
1310:
1306:
1279:
1270:
1258:. Retrieved
1254:
1244:
1233:
1221:. Retrieved
1217:the original
1212:
1203:
1181:the original
1176:
1166:
1139:
1135:
1125:
1113:. Retrieved
1106:the original
1093:
1058:
1054:
1028:: Sarilumab
1006:. Retrieved
999:the original
944:
940:
934:
925:
916:
906:28 September
904:. Retrieved
900:the original
886:
874:ama-assn.org
873:
859:
847:. Retrieved
842:
833:
821:. Retrieved
816:
807:
795:. Retrieved
790:
781:
769:. Retrieved
767:. 8 May 2018
762:
753:
741:. Retrieved
733:
724:
710:
698:
691:
670:
662:
649:
647:
644:
640:methotrexate
637:
634:
597:
586:
583:Side effects
577:tuberculosis
570:
557:methotrexate
553:
550:Medical uses
544:methotrexate
537:
501:
497:
496:
485:
479:
351:1189541-98-7
324:Elimination
232:Legal status
226:Legal status
195:Subcutaneous
158:License data
58:
48:January 2022
45:
37:
4973:Ustekinumab
4953:Briakinumab
4945:Antibodies:
4916:Fezakinumab
4913:Antibodies:
4877:Antibodies:
4865:Denenicokin
4840:Antibodies:
4777:Iboctadekin
4756:Vunakizumab
4751:Secukinumab
4741:Perakizumab
4728:Antibodies:
4636:Antibodies:
4593:Ustekinumab
4588:Briakinumab
4585:Antibodies:
4497:Antibodies:
4423:Tocilizumab
4393:Elsilimomab
4380:Antibodies:
4332:Mepolizumab
4324:Antibodies:
4278:Antibodies:
4205:Daniplestim
4174:Basiliximab
4171:Antibodies:
4139:Celmoleukin
4134:Aldesleukin
4098:Lutikizumab
4093:Gevokizumab
4088:Canakinumab
4085:Antibodies:
3954:from market
3924:Lemalesomab
3919:Fanolesomab
3914:Besilesomab
3853:Perakizumab
3838:Mirikizumab
3828:Gevokizumab
3818:Bimekizumab
3797:Ustekinumab
3782:Secukinumab
3767:Fezakinumab
3762:Canakinumab
3757:Briakinumab
3732:Interleukin
3685:Dostarlimab
3664:Visilizumab
3659:Vedolizumab
3654:Vatelizumab
3644:Toralizumab
3639:Tocilizumab
3624:Teclistamab
3599:Samalizumab
3589:Rovelizumab
3569:Ravulizumab
3549:Pidilizumab
3544:Pexelizumab
3509:Ocrelizumab
3504:Natalizumab
3494:Mepolizumab
3484:Ligelizumab
3479:Letolizumab
3449:Etrolizumab
3439:Epratuzumab
3409:Cedelizumab
3363:Vapaliximab
3358:Teneliximab
3348:Lumiliximab
3333:Gomiliximab
3318:Basiliximab
3290:Vepalimomab
3275:Nerelimomab
3260:Gavilimomab
3255:Faralimomab
3250:Elsilimomab
3225:Combination
3218:Zanolimumab
3213:Ontamalimab
3161:Ulocuplumab
3156:Tezepelumab
3146:Sifalimumab
3126:Pamrevlumab
3105:Morolimumab
3100:Metelimumab
3070:Lanadelumab
3005:Avdoralimab
2990:Anifrolumab
2900:Tofacitinib
2840:Ravulizumab
2830:Pirfenidone
2820:Peficitinib
2720:Canakinumab
2710:Briakinumab
2700:Bimekizumab
2695:Baricitinib
2660:Aflibercept
2571:Vepalimomab
2566:Vapaliximab
2541:Rovelizumab
2531:Pexelizumab
2521:Morolimumab
2496:Cedelizumab
2481:Anifrolumab
2476:Alemtuzumab
2434:Basiliximab
2404:Tocilizumab
2390:Vedolizumab
2385:Natalizumab
2371:Metelimumab
2314:Gavilimomab
2272:Toralizumab
2267:Teneliximab
2253:Lumiliximab
2248:Gomiliximab
2234:Ublituximab
2214:Ocrelizumab
2167:Zanolimumab
2143:Visilizumab
2101:Secukinumab
2085:Ustekinumab
2056:Elsilimomab
2040:Faralimomab
2008:Mepolizumab
1992:Ustekinumab
1987:Tocilizumab
1962:Secukinumab
1912:Canakinumab
1902:Briakinumab
1897:Bimekizumab
1892:Basiliximab
1881:Interleukin
1871:Nerelimomab
1776:Zotarolimus
1717:(reception)
1688:Thalidomide
1646:Voclosporin
1631:Ciclosporin
1625:Calcineurin
1621:Cyclophilin
1568:Leflunomide
1564:inhibitors
1008:29 November
759:"Arthritis"
701:Tocilizumab
589:neutropenia
473: g·mol
336:Identifiers
144:MedlinePlus
116:Trade names
5282:Categories
5028:B (IFN-λ3)
5024:A (IFN-λ2)
4958:Guselkumab
4948:Brazikumab
4843:Fletikumab
4746:Remtolumab
4736:Ixekizumab
4731:Brodalumab
4614:Binetrakin
4552:Oprelvekin
4521:Ilodecakin
4500:Enokizumab
4413:Siltuximab
4403:Olokizumab
4337:Reslizumab
4271:Pitrakinra
4251:Binetrakin
4220:Milodistim
4215:Leridistim
4184:Inolimomab
4159:Teceleukin
4078:Isunakinra
4015:modulators
3884:Lokivetmab
3877:Veterinary
3863:Spesolimab
3848:Olokizumab
3833:Ixekizumab
3777:Guselkumab
3772:Fletikumab
3752:Brazikumab
3747:Bermekimab
3718:Sutimlimab
3692:Ibalizumab
3629:Teplizumab
3609:Siplizumab
3594:Ruplizumab
3574:Reslizumab
3564:Quilizumab
3519:Omalizumab
3469:Itolizumab
3459:Frexalimab
3434:Efalizumab
3429:Eculizumab
3424:Daclizumab
3389:Aselizumab
3384:Apolizumab
3353:Priliximab
3338:Infliximab
3280:Odulimomab
3270:Maslimomab
3265:Inolimomab
3245:Afelimomab
3182:Durvalumab
3177:Ipilimumab
3166:Varlilumab
3136:Relatlimab
3131:Placulumab
3075:Lenzilumab
3050:Emapalumab
3035:Cemiplimab
3020:Brodalumab
3015:Bleselumab
2985:Adalimumab
2890:Sutimlimab
2885:Spesolimab
2870:Siltuximab
2810:Olokizumab
2800:Ixekizumab
2795:Itacitinib
2785:Guselkumab
2780:Fingolimod
2775:Filgotinib
2725:Crovalimab
2715:Brodalumab
2705:Blisibimod
2670:Rilonacept
2653:Opinercept
2648:Etanercept
2634:Belatacept
2585:Polyclonal
2546:Siplizumab
2536:Reslizumab
2526:Ofatumumab
2516:Maslimomab
2501:Emapalumab
2444:Inolimomab
2439:Daclizumab
2418:Odulimomab
2333:Ruplizumab
2328:Frexalimab
2286:Aselizumab
2181:Efalizumab
2138:Teplizumab
2034:Interferon
2024:Omalizumab
1977:Spesolimab
1967:Siltuximab
1942:Rilonacept
1937:Olokizumab
1927:Ixekizumab
1922:Guselkumab
1917:Daclizumab
1907:Brodalumab
1866:Infliximab
1851:Afelimomab
1846:Adalimumab
1830:Eculizumab
1806:Monoclonal
1797:Antibodies
1771:Umirolimus
1751:Everolimus
1700:Apremilast
1660:Gusperimus
1641:Tacrolimus
1609:inhibitors
1601:Macrolides
1583:antifolate
1171:Walker T.
743:22 October
716:References
696:symptoms.
654:adalimumab
593:adalimumab
563:(DMARDs).
462:Molar mass
387:NU90V55F8I
362:ChemSpider
342:CAS Number
311:Metabolism
5233:Unsorted:
5094:Agonists:
5073:Agonists:
5052:Agonists:
5012:Agonists:
4991:Agonists:
4935:Agonists:
4903:Agonists:
4862:Agonists:
4820:Agonists:
4792:Tadekinig
4774:Agonists:
4693:Agonists:
4667:Agonists:
4611:Agonists:
4570:Agonists:
4544:Agonists:
4518:Agonists:
4487:Agonists:
4446:Agonists:
4428:Levilimab
4418:Sirukumab
4408:Sarilumab
4365:Agonists:
4304:Agonists:
4281:Dupilumab
4248:Agonists:
4225:Muplestim
4202:Agonists:
4126:Agonists:
4053:Pifonakin
4048:Mobenakin
4031:Agonists:
3964:Phase III
3952:Withdrawn
3929:Sulesomab
3806:Humanized
3787:Sirukumab
3619:Talizumab
3444:Erlizumab
3373:Humanized
3343:Keliximab
3328:Galiximab
3187:Nivolumab
3151:Tabalumab
3141:Sarilumab
3115:Oleclumab
3110:Namilumab
3090:Lirilumab
3065:Ianalumab
3060:Golimumab
3045:Eldelumab
3040:Dupilumab
3010:Belimumab
2980:Abrilumab
2880:Sirukumab
2875:Siponimod
2860:Sarilumab
2835:Ponesimod
2805:Netakimab
2790:Iptacopan
2770:Etrasimod
2730:Danicopan
2665:Alefacept
2629:Abatacept
2551:Talizumab
2491:Begelomab
2347:Belimumab
2300:Galiximab
2229:Rituximab
2195:Erlizumab
2162:Keliximab
1972:Sirukumab
1952:Sarilumab
1932:Netakimab
1861:Golimumab
1761:Sirolimus
1260:7 January
1031:Monograph
1026:Drugs.com
849:26 August
823:26 August
559:or other
498:Sarilumab
326:half-life
317:proteases
188:Routes of
177:Sarilumab
136:Monograph
130:Drugs.com
63:Sarilumab
5272:Medicine
5187:IL-22Rα1
5153:instead.
4470:instead.
4398:mAb 1339
4383:ARGX-109
4347:TPI ASM8
4317:YM-90709
4068:Anakinra
4063:AF-12198
3305:Chimeric
3197:Urelumab
3120:Oxelumab
3030:Carlumab
3000:Avelumab
2949:for the
2815:Ozanimod
2690:Avacopan
2683:Unsorted
2469:Unsorted
2379:Integrin
2112:Cellular
1887:Anakinra
1733:Anakinra
1655:Abetimus
1507: /
1466:28579757
1421:29492111
1378:29746672
1335:46969760
1327:29882210
1255:BBC News
1223:9 August
1189:cite web
1158:25733246
1085:27856432
961:29482351
817:DailyMed
797:13 April
771:13 April
694:COVID-19
688:COVID-19
683:Research
610:and the
604:platelet
513:receptor
488:(verify)
202:ATC code
172:DailyMed
5205:IL-10Rβ
5201:IL-20Rα
5191:IL-20Rβ
5125:IL-36RA
4670:ALT-803
3899:lesions
3674:TGN1412
3559:PRO 140
2611:-cept (
1457:5447699
1412:5802641
1369:6055572
1076:5530335
969:3580054
667:History
650:MONARCH
502:Kevzara
423:Formula
315:likely
275:Rx-only
272:WARNING
257::
218:)
212: (
210:L04AC14
174::
150:a617032
120:Kevzara
38:updated
5298:Sanofi
5258:Portal
5161:Others
5134:Others
5086:IL1RL2
5065:IL1RL1
4802:IL18BP
4073:IL-1RA
3947:WHO-EM
3689:Other:
2623:CTLA-4
2613:Fusion
2114:target
2095:IL-17A
2072:, and
1605:other
1464:
1454:
1419:
1409:
1376:
1366:
1333:
1325:
1156:
1115:15 May
1083:
1073:
967:
959:
618:, and
521:Sanofi
407:D10161
269:
259:℞-only
245:
170:
99:Target
87:Source
5044:IL-31
5004:IL-28
4983:IL-27
4927:IL-23
4895:IL-22
4854:IL-21
4812:IL-20
4766:IL-18
4685:IL-17
4659:IL-15
4603:IL-13
4562:IL-12
4536:IL-11
4510:IL-10
3907:Mouse
3740:Human
3238:Mouse
3204:Other
2967:Human
2412:LFA-1
2322:CD154
2175:CD11a
2074:IL-23
2070:IL-13
2066:IL-12
1670:IMiDs
1331:S2CID
1303:(PDF)
1109:(PDF)
1102:(PDF)
1002:(PDF)
991:(PDF)
965:S2CID
870:(PDF)
658:DAS28
602:(low
104:IL-6R
92:Human
5151:here
5149:See
4479:IL-9
4468:here
4459:IL-8
4438:IL-7
4357:IL-6
4296:IL-5
4240:IL-4
4194:IL-3
4118:IL-2
4023:IL-1
2342:BLyS
2294:CD80
2261:CD40
2242:CD23
2203:CD20
2189:CD18
2050:IL-6
1743:mTOR
1617:FKBP
1607:IL-2
1462:PMID
1417:PMID
1374:PMID
1323:PMID
1262:2021
1225:2019
1195:link
1154:PMID
1117:2013
1081:PMID
1010:2017
957:PMID
908:2017
851:2024
825:2024
799:2024
773:2024
745:2023
519:and
449:1998
443:1718
437:9918
431:6388
398:KEGG
378:UNII
369:none
295:data
126:AHFS
77:Type
5177:CD4
5142:JAK
2355:CAT
2151:CD4
2122:CD3
1840:TNF
1513:L04
1452:PMC
1442:doi
1407:PMC
1399:doi
1364:PMC
1356:doi
1315:doi
1144:doi
1071:PMC
1063:doi
949:doi
738:FDA
529:FDA
471:.28
469:164
467:144
305:80%
215:WHO
5284::
5107:,
5103:,
5026:,
4718:,
4714:,
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280:EU
265:US
254:CA
247:S4
241:AU
167:US
5260::
5222:)
5203:/
5189:/
5179:)
5111:)
5109:γ
5105:β
5101:α
5099:(
5030:)
5022:(
4722:)
4720:F
4712:D
4708:C
4704:B
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