Knowledge (XXG)

M62812

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Nakamura M, Shimizu Y, Sato Y, Miyazaki Y, Satoh T, Mizuno M, et al. (August 2007). "Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice".
274: 260: 417:"TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model" 521: 294: 44: 540: 126: 560: 166: 514: 545: 155: 507: 428: 321: 182: 61: 550: 456: 397: 302:
InChI=1S/C13H11N3OS/c14-10-3-1-2-4-11(10)17-8-5-6-9-12(7-8)18-16-13(9)15/h1-7H,14H2,(H2,15,16)
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Park H, Hong J, Yin Y, Joo Y, Kim Y, Shin J, et al. (October 2020).
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is a drug which acts as a potent and selective antagonist of
171: 495: 248: 235: 202: 197: 165: 145: 125: 105: 80: 60: 35: 324:(TLR4). In animal studies it blocks TLR4-mediated 94: 69: 332:effects, showing efficacy in animal models of 515: 8: 19: 52:6-(2-aminophenoxy)-1,2-benzothiazol-3-amine 522: 508: 185: 114: 27: 450: 440: 134: 371: 299: 282:C1=CC=C(C(=C1)N)OC2=CC3=C(C=C2)C(=NS3)N 279: 181: 49: 18: 154: 7: 476: 474: 85: 494:. You can help Knowledge (XXG) by 14: 478: 382:European Journal of Pharmacology 220: 214: 307:Key:HQCTTYOADNAJJR-UHFFFAOYSA-N 229: 226: 208: 1: 394:10.1016/j.ejphar.2007.05.013 577: 473: 442:10.1038/s41598-020-74544-5 198:Chemical and physical data 290: 270: 40: 26: 490:-related article is a 541:Receptor antagonists 322:toll-like receptor 4 433:2020NatSR..1017451P 23: 561:Pharmacology stubs 421:Scientific Reports 503: 502: 315: 314: 261:Interactive image 167:CompTox Dashboard 16:Chemical compound 568: 524: 517: 510: 482: 475: 465: 464: 454: 444: 412: 406: 405: 376: 330:antiinflammatory 328:release and has 263: 243: 231: 228: 222: 216: 210: 190: 189: 175: 173: 158: 138: 118: 98: 88: 87: 73: 31: 24: 22: 576: 575: 571: 570: 569: 567: 566: 565: 531: 530: 529: 528: 471: 469: 468: 414: 413: 409: 378: 377: 373: 368: 346: 311: 308: 303: 298: 297: 286: 283: 278: 277: 266: 241: 225: 219: 213: 193: 183:DTXSID701336699 169: 161: 141: 121: 101: 84: 76: 56: 53: 48: 47: 17: 12: 11: 5: 574: 572: 564: 563: 558: 553: 548: 546:Benzothiazoles 543: 533: 532: 527: 526: 519: 512: 504: 501: 500: 483: 467: 466: 407: 370: 369: 367: 364: 363: 362: 357: 352: 345: 342: 313: 312: 310: 309: 306: 304: 301: 293: 292: 291: 288: 287: 285: 284: 281: 273: 272: 271: 268: 267: 265: 264: 256: 254: 246: 245: 239: 233: 232: 223: 217: 211: 206: 200: 199: 195: 194: 192: 191: 178: 176: 163: 162: 160: 159: 151: 149: 143: 142: 140: 139: 131: 129: 123: 122: 120: 119: 111: 109: 103: 102: 100: 99: 91: 89: 78: 77: 75: 74: 66: 64: 58: 57: 55: 54: 51: 43: 42: 41: 38: 37: 33: 32: 15: 13: 10: 9: 6: 4: 3: 2: 573: 562: 559: 557: 554: 552: 549: 547: 544: 542: 539: 538: 536: 525: 520: 518: 513: 511: 506: 505: 499: 497: 493: 489: 484: 481: 477: 472: 462: 458: 453: 448: 443: 438: 434: 430: 426: 422: 418: 411: 408: 403: 399: 395: 391: 388:(3): 237–43. 387: 383: 375: 372: 365: 361: 358: 356: 353: 351: 348: 347: 343: 341: 339: 335: 331: 327: 323: 319: 305: 300: 296: 289: 280: 276: 269: 262: 258: 257: 255: 252: 247: 240: 238: 234: 207: 205: 201: 196: 188: 184: 180: 179: 177: 168: 164: 157: 153: 152: 150: 148: 144: 137: 133: 132: 130: 128: 124: 117: 113: 112: 110: 108: 104: 97: 93: 92: 90: 83: 79: 72: 68: 67: 65: 63: 59: 50: 46: 39: 34: 30: 25: 496:expanding it 488:pharmacology 485: 470: 427:(1): 17451. 424: 420: 410: 385: 381: 374: 338:septic shock 317: 316: 156:ChEMBL458612 350:TLR4-IN-C34 244: g·mol 71:613262-61-6 36:Identifiers 535:Categories 366:References 355:Resatorvid 249:3D model ( 237:Molar mass 136:D98NBX7QJ5 107:ChemSpider 62:CAS Number 45:IUPAC name 334:arthritis 551:Anilines 461:33060735 402:17588563 360:VGX-1027 344:See also 326:cytokine 116:24691458 96:44224215 452:7567100 429:Bibcode 204:Formula 82:PubChem 556:Amines 459:  449:  400:  318:M62812 275:SMILES 242:257.31 147:ChEMBL 21:M62812 486:This 295:InChI 251:JSmol 492:stub 457:PMID 398:PMID 336:and 127:UNII 447:PMC 437:doi 390:doi 386:569 172:EPA 86:CID 537:: 455:. 445:. 435:. 425:10 423:. 419:. 396:. 384:. 340:. 218:11 212:13 523:e 516:t 509:v 498:. 463:. 439:: 431:: 404:. 392:: 253:) 230:S 227:O 224:3 221:N 215:H 209:C 174:) 170:(

Index


IUPAC name
CAS Number
613262-61-6
PubChem
44224215
ChemSpider
24691458
UNII
D98NBX7QJ5
ChEMBL
ChEMBL458612
CompTox Dashboard
DTXSID701336699
Edit this at Wikidata
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
toll-like receptor 4
cytokine
antiinflammatory
arthritis
septic shock
TLR4-IN-C34
Resatorvid
VGX-1027
doi

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