Knowledge (XXG)

TLR4-IN-C34

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Zhang SS, Liu M, Liu DN, Yang YL, Du GH, Wang YH (April 2022). "TLR4-IN-C34 Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses via Downregulating TLR4/MyD88/NF-κB/NLRP3 Signaling Pathway and Reducing ROS Generation in BV2 Cells".
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Sivak KV, Stosman KI, Rassokha TA, Aleksandrov AG, Kuzmich NN, Orshanskaya YR, et al. (October 2020). "The Effect of TLR4 Blockade on Some Indicators of Systemic Inflammatory Response to Proteus mirabilis LPS in Rats".
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Adegoke EO, Adeniran SO, Zeng Y, Wang X, Wang H, Wang C, et al. (June 2019). "Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells".
393:"Lactobacillus salivarius BP121 prevents cisplatin‑induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p‑cresol sulfate via alleviating dysbiosis" 251: 279:
InChI=1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1
616: 271: 44: 635: 645: 650: 146: 609: 530:"TLR4-IN-C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis" 135: 602: 302: 162: 640: 61: 510: 466: 373: 551: 502: 458: 422: 365: 115: 586: 541: 494: 450: 412: 404: 357: 310: 183: 166: 70: 546: 529: 417: 392: 28: 629: 514: 470: 95: 377: 582: 498: 454: 327: 213: 106: 20: 555: 506: 462: 426: 408: 369: 574: 306: 391:
Lee TH, Park D, Kim YJ, Lee I, Kim S, Oh CT, et al. (April 2020).
81: 361: 322: 126: 236: 227: 301:) is a drug which acts as a potent and selective antagonist of 151: 528:
Abdelsalam HM, Helal MG, Abu-Elsaad NM (November 2022).
590: 225: 212: 182: 177: 145: 125: 105: 80: 60: 35: 305:(TLR4). In animal studies it blocks TLR4-mediated 94: 69: 259:CC(C)O1((((O1)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C 610: 443:Bulletin of Experimental Biology and Medicine 8: 19: 397:International Journal of Molecular Medicine 617: 603: 165: 114: 27: 545: 534:Iranian Journal of Basic Medical Sciences 416: 339: 276: 256: 161: 49: 18: 134: 7: 571: 569: 85: 589:. You can help Knowledge (XXG) by 14: 573: 200: 194: 284:Key:KMIQMFHPUJUDMC-HHARLNAUSA-N 203: 188: 1: 350:Journal of Applied Toxicology 667: 568: 499:10.1007/s10753-021-01588-8 455:10.1007/s10517-020-04981-9 178:Chemical and physical data 267: 247: 40: 26: 585:-related article is a 409:10.3892/ijmm.2020.4495 636:Receptor antagonists 303:Toll-like receptor 4 646:Oxygen heterocycles 23: 651:Pharmacology stubs 598: 597: 540:(11): 1334–1340. 292: 291: 238:Interactive image 147:CompTox Dashboard 16:Chemical compound 658: 619: 612: 605: 577: 570: 560: 559: 549: 525: 519: 518: 481: 475: 474: 437: 431: 430: 420: 403:(4): 1130–1140. 388: 382: 381: 362:10.1002/jat.3771 344: 311:antiinflammatory 309:release and has 240: 220: 205: 202: 196: 190: 170: 169: 155: 153: 138: 118: 98: 88: 87: 73: 31: 24: 22: 666: 665: 661: 660: 659: 657: 656: 655: 626: 625: 624: 623: 566: 564: 563: 527: 526: 522: 483: 482: 478: 439: 438: 434: 390: 389: 385: 346: 345: 341: 336: 319: 288: 285: 280: 275: 274: 263: 260: 255: 254: 243: 218: 208: 199: 193: 173: 163:DTXSID001336698 149: 141: 121: 101: 84: 76: 56: 53: 48: 47: 17: 12: 11: 5: 664: 662: 654: 653: 648: 643: 638: 628: 627: 622: 621: 614: 607: 599: 596: 595: 578: 562: 561: 520: 493:(2): 838–850. 476: 449:(6): 795–797. 432: 383: 356:(6): 832–843. 338: 337: 335: 332: 331: 330: 325: 318: 315: 290: 289: 287: 286: 283: 281: 278: 270: 269: 268: 265: 264: 262: 261: 258: 250: 249: 248: 245: 244: 242: 241: 233: 231: 223: 222: 216: 210: 209: 206: 197: 191: 186: 180: 179: 175: 174: 172: 171: 158: 156: 143: 142: 140: 139: 131: 129: 123: 122: 120: 119: 111: 109: 103: 102: 100: 99: 91: 89: 78: 77: 75: 74: 66: 64: 58: 57: 55: 54: 52:methyl acetate 51: 43: 42: 41: 38: 37: 33: 32: 15: 13: 10: 9: 6: 4: 3: 2: 663: 652: 649: 647: 644: 642: 639: 637: 634: 633: 631: 620: 615: 613: 608: 606: 601: 600: 594: 592: 588: 584: 579: 576: 572: 567: 557: 553: 548: 543: 539: 535: 531: 524: 521: 516: 512: 508: 504: 500: 496: 492: 488: 480: 477: 472: 468: 464: 460: 456: 452: 448: 444: 436: 433: 428: 424: 419: 414: 410: 406: 402: 398: 394: 387: 384: 379: 375: 371: 367: 363: 359: 355: 351: 343: 340: 333: 329: 326: 324: 321: 320: 316: 314: 312: 308: 304: 300: 296: 282: 277: 273: 266: 257: 253: 246: 239: 235: 234: 232: 229: 224: 217: 215: 211: 187: 185: 181: 176: 168: 164: 160: 159: 157: 148: 144: 137: 136:ChEMBL4303607 133: 132: 130: 128: 124: 117: 113: 112: 110: 108: 104: 97: 93: 92: 90: 83: 79: 72: 68: 67: 65: 63: 59: 50: 46: 39: 34: 30: 25: 591:expanding it 583:pharmacology 580: 565: 537: 533: 523: 490: 487:Inflammation 486: 479: 446: 442: 435: 400: 396: 386: 353: 349: 342: 298: 294: 293: 295:TLR4-IN-C34 221: g·mol 36:Identifiers 21:TLR4-IN-C34 641:Acetamides 630:Categories 334:References 328:Resatorvid 226:3D model ( 214:Molar mass 107:ChemSpider 71:40592-88-9 62:CAS Number 45:IUPAC name 515:241108525 471:225058037 313:effects. 556:36474570 507:34727285 463:33098506 427:32124946 378:58948493 370:30671980 317:See also 307:cytokine 116:34500445 96:91691128 547:9699956 418:7053870 219:389.401 184:Formula 82:PubChem 554:  544:  513:  505:  469:  461:  425:  415:  376:  368:  323:M62812 252:SMILES 127:ChEMBL 581:This 511:S2CID 467:S2CID 374:S2CID 272:InChI 228:JSmol 587:stub 552:PMID 503:PMID 459:PMID 423:PMID 366:PMID 297:(or 542:PMC 495:doi 451:doi 447:169 413:PMC 405:doi 358:doi 299:C34 152:EPA 86:CID 632:: 550:. 538:25 536:. 532:. 509:. 501:. 491:45 489:. 465:. 457:. 445:. 421:. 411:. 401:45 399:. 395:. 372:. 364:. 354:39 352:. 198:27 192:17 618:e 611:t 604:v 593:. 558:. 517:. 497:: 473:. 453:: 429:. 407:: 380:. 360:: 230:) 207:9 204:O 201:N 195:H 189:C 154:) 150:(

Index


IUPAC name
CAS Number
40592-88-9
PubChem
91691128
ChemSpider
34500445
ChEMBL
ChEMBL4303607
CompTox Dashboard
DTXSID001336698
Edit this at Wikidata
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
Toll-like receptor 4
cytokine
antiinflammatory
M62812
Resatorvid
doi
10.1002/jat.3771
PMID
30671980
S2CID
58948493

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