220:, since mice lacking Dok-7 failed to form AChR clusters or neuromuscular synapses, and since downregulation of CK2 also impedes recruitment of AChR to the primary MuSK scaffold. In addition to the proteins mentioned, other proteins are then gathered, to form the endplate to the neuromuscular junction. The nerve terminates onto the endplate, forming the neuromuscular junction - a structure required to transmit nerve impulses to the muscle, and thus initiating muscle contraction.
1976:
29:
252:
Valenzuela DM, Stitt TN, DiStefano PS, Rojas E, Mattsson K, Compton DL, Nunez L, Park JS, Stark JL, Gies DR, Thomas S, LeBeau MM, Fernald AA, Copeland NG, Jenkins NA, Burden SJ, Glass DJ, Yancopoulos GD (Sep 1995).
602:
Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A (Mar 2001). "Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies".
302:
DeChiara TM, Bowen DC, Valenzuela DM, Simmons MV, Poueymirou WT, Thomas S, Kinetz E, Compton DL, Rojas E, Park JS, Smith C, DiStefano PS, Glass DJ, Burden SJ, Yancopoulos GD (May 1996).
236:. The disease still causes loss of acetylcholine receptor activity, but the symptoms affected people experience may differ from those of people with other causes of myasthenia gravis.
646:
Barrett-Jolley R, Byrne N, Vincent A, Newsom-Davis J (Oct 1994). "Plasma from patients with seronegative myasthenia gravis inhibit nAChR responses in the TE671/RD cell line".
449:
Glass DJ, Bowen DC, Stitt TN, Radziejewski C, Bruno J, Ryan TE, Gies DR, Shah S, Mattson K, Burden SJ, DiStefano PS, Valenzuela DM, DeChiara TM, Yancopoulos GD (May 1996).
351:
Glass DJ, Bowen DC, Stitt TN, Radziejewski C, Bruno J, Ryan TE, Gies DR, Shah S, Mattson K, Burden SJ, DiStefano PS, Valenzuela DM, DeChiara TM, Yancopoulos GD (May 1996).
1121:
49:
547:
Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, Kubo S, Shiraishi H, Eguchi K, Motomura M, Akiyama T, Iwakura Y, Higuchi O, Yamanashi Y (Jun 2006).
1545:
706:
1418:
255:"Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury"
844:
1159:
801:
498:
Cheusova T, Khan MA, Schubert SW, Gavin AC, Buchou T, Jacob G, Sticht H, Allende J, Boldyreff B, Brenner HR, Hashemolhosseini S (Jul 2006).
1996:
829:
2006:
1197:
1188:
888:
883:
878:
873:
73:
2001:
1082:
1073:
500:"Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction"
1695:
864:
767:
61:
54:
699:
1851:
912:
1966:
1343:
1275:
1266:
1649:
1640:
1576:
1404:
1620:
1087:
1836:
1952:
1939:
1926:
1913:
1900:
1887:
1874:
692:
1846:
1800:
1743:
737:
723:
173:
1748:
1461:
1452:
750:
233:
217:
177:
66:
1769:
1688:
1413:
1097:
1841:
560:
119:
1805:
1111:
228:
Antibodies directed against this protein (Anti-MuSK autoantibodies) are found in some people with
1738:
1495:
1485:
1476:
1304:
1295:
671:
628:
584:
480:
431:
382:
333:
284:
684:
548:
2011:
1529:
663:
620:
576:
529:
472:
423:
374:
325:
276:
229:
1784:
1779:
1753:
1681:
806:
792:
655:
612:
568:
519:
511:
462:
413:
364:
315:
304:"The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo"
266:
114:
1053:
123:
1831:
1815:
1728:
1394:
1063:
1048:
1038:
1033:
1013:
1008:
1003:
998:
993:
984:
719:
201:
143:
564:
1980:
1869:
1810:
1524:
1519:
1514:
898:
715:
524:
499:
467:
450:
418:
401:
369:
352:
320:
303:
1990:
1774:
1733:
960:
821:
400:
Gautam M, Noakes PG, Moscoso L, Rupp F, Scheller RH, Merlie JP, Sanes JR (May 1996).
271:
254:
632:
588:
484:
435:
386:
337:
288:
1723:
1505:
951:
675:
181:
90:
1947:
1882:
1718:
153:
1975:
1630:
1625:
1615:
1610:
1601:
1550:
1466:
1356:
97:
1921:
1895:
572:
624:
580:
533:
667:
476:
427:
378:
329:
280:
1365:
772:
188:, which is similarly also required for neuromuscular junction formation.
102:
549:"The muscle protein Dok-7 is essential for neuromuscular synaptogenesis"
659:
515:
402:"Defective neuromuscular synaptogenesis in agrin-deficient mutant mice"
1934:
1704:
1654:
917:
853:
848:
216:). Both CK2 and Dok-7 are required for MuSK-induced formation of the
209:
85:
28:
1908:
1442:
1320:
1285:
1280:
1256:
1058:
1043:
1028:
1023:
1018:
970:
965:
941:
936:
927:
839:
834:
811:
782:
777:
616:
205:
197:
185:
1560:
1490:
1437:
1428:
1389:
1380:
1370:
1251:
1242:
1232:
1178:
1169:
1154:
1145:
1135:
1130:
1106:
907:
759:
213:
78:
1677:
1341:
735:
688:
1591:
1586:
1581:
1555:
1673:
1964:
212:, to induce "clustering" of acetylcholine receptors (
1860:
1824:
1793:
1762:
1711:
1639:
1600:
1569:
1538:
1504:
1475:
1451:
1427:
1403:
1379:
1355:
1313:
1294:
1265:
1241:
1225:
1206:
1187:
1168:
1144:
1120:
1096:
1072:
983:
950:
926:
897:
863:
820:
791:
758:
749:
149:
139:
134:
113:
108:
96:
84:
72:
60:
48:
40:
35:
21:
176:required for the formation and maintenance of the
1689:
700:
8:
1696:
1682:
1674:
1352:
1338:
755:
746:
732:
707:
693:
685:
131:
27:
22:muscle, skeletal, receptor tyrosine kinase
523:
466:
417:
368:
319:
270:
451:"Agrin acts via a MuSK receptor complex"
353:"Agrin acts via a MuSK receptor complex"
1971:
244:
200:, MuSK signals via the proteins called
16:Mammalian protein found in Homo sapiens
18:
180:. It is activated by a nerve-derived
7:
232:not demonstrating antibodies to the
14:
1974:
196:Upon activation by its ligand
1:
1344:Non-receptor tyrosine kinases
468:10.1016/s0092-8674(00)81252-0
419:10.1016/s0092-8674(00)81253-2
370:10.1016/s0092-8674(00)81252-0
321:10.1016/s0092-8674(00)81251-9
272:10.1016/0896-6273(95)90146-9
1997:Genes on human chromosome 9
2028:
2007:Developmental neuroscience
2002:Tyrosine kinase receptors
1852:Michaelis–Menten kinetics
1351:
1337:
745:
738:Receptor tyrosine kinases
731:
130:
26:
1744:Diffusion-limited enzyme
174:receptor tyrosine kinase
751:Growth factor receptors
573:10.1126/science.1127142
504:Genes & Development
234:acetylcholine receptor
218:neuromuscular junction
178:neuromuscular junction
170:Muscle-Specific Kinase
1837:Eadie–Hofstee diagram
1770:Allosteric regulation
1847:Lineweaver–Burk plot
822:PDGF receptor family
1226:ROS receptor family
760:EGF receptor family
565:2006Sci...312.1802O
1806:Enzyme superfamily
1739:Enzyme promiscuity
660:10.1007/BF00374570
516:10.1101/gad.375206
1962:
1961:
1671:
1670:
1667:
1666:
1663:
1662:
1333:
1332:
1329:
1328:
979:
978:
230:myasthenia gravis
163:
162:
159:
158:
2019:
1979:
1978:
1970:
1842:Hanes–Woolf plot
1785:Enzyme activator
1780:Enzyme inhibitor
1754:Enzyme catalysis
1698:
1691:
1684:
1675:
1353:
1339:
793:Insulin receptor
756:
747:
733:
720:tyrosine kinases
709:
702:
695:
686:
680:
679:
643:
637:
636:
599:
593:
592:
559:(5781): 1802–5.
544:
538:
537:
527:
495:
489:
488:
470:
446:
440:
439:
421:
397:
391:
390:
372:
348:
342:
341:
323:
299:
293:
292:
274:
249:
132:
31:
19:
2027:
2026:
2022:
2021:
2020:
2018:
2017:
2016:
1987:
1986:
1985:
1973:
1965:
1963:
1958:
1870:Oxidoreductases
1856:
1832:Enzyme kinetics
1820:
1816:List of enzymes
1789:
1758:
1729:Catalytic triad
1707:
1702:
1672:
1659:
1635:
1596:
1565:
1534:
1500:
1471:
1447:
1423:
1399:
1375:
1347:
1325:
1309:
1290:
1261:
1237:
1221:
1202:
1183:
1164:
1140:
1116:
1092:
1068:
975:
946:
922:
893:
859:
816:
787:
741:
727:
716:Protein kinases
713:
683:
648:PflĂĽgers Archiv
645:
644:
640:
605:Nature Medicine
601:
600:
596:
546:
545:
541:
510:(13): 1800–16.
497:
496:
492:
448:
447:
443:
399:
398:
394:
350:
349:
345:
301:
300:
296:
251:
250:
246:
242:
226:
224:Role in disease
202:casein kinase 2
194:
17:
12:
11:
5:
2025:
2023:
2015:
2014:
2009:
2004:
1999:
1989:
1988:
1984:
1983:
1960:
1959:
1957:
1956:
1943:
1930:
1917:
1904:
1891:
1878:
1864:
1862:
1858:
1857:
1855:
1854:
1849:
1844:
1839:
1834:
1828:
1826:
1822:
1821:
1819:
1818:
1813:
1808:
1803:
1797:
1795:
1794:Classification
1791:
1790:
1788:
1787:
1782:
1777:
1772:
1766:
1764:
1760:
1759:
1757:
1756:
1751:
1746:
1741:
1736:
1731:
1726:
1721:
1715:
1713:
1709:
1708:
1703:
1701:
1700:
1693:
1686:
1678:
1669:
1668:
1665:
1664:
1661:
1660:
1658:
1657:
1652:
1646:
1644:
1637:
1636:
1634:
1633:
1628:
1623:
1618:
1613:
1607:
1605:
1598:
1597:
1595:
1594:
1589:
1584:
1579:
1573:
1571:
1567:
1566:
1564:
1563:
1558:
1553:
1548:
1542:
1540:
1536:
1535:
1533:
1532:
1527:
1522:
1517:
1511:
1509:
1502:
1501:
1499:
1498:
1493:
1488:
1482:
1480:
1473:
1472:
1470:
1469:
1464:
1458:
1456:
1449:
1448:
1446:
1445:
1440:
1434:
1432:
1425:
1424:
1422:
1421:
1416:
1410:
1408:
1401:
1400:
1398:
1397:
1392:
1386:
1384:
1377:
1376:
1374:
1373:
1368:
1362:
1360:
1349:
1348:
1342:
1335:
1334:
1331:
1330:
1327:
1326:
1324:
1323:
1317:
1315:
1311:
1310:
1308:
1307:
1301:
1299:
1292:
1291:
1289:
1288:
1283:
1278:
1272:
1270:
1263:
1262:
1260:
1259:
1254:
1248:
1246:
1243:AATYK receptor
1239:
1238:
1236:
1235:
1229:
1227:
1223:
1222:
1220:
1219:
1213:
1211:
1204:
1203:
1201:
1200:
1194:
1192:
1185:
1184:
1182:
1181:
1175:
1173:
1166:
1165:
1163:
1162:
1157:
1151:
1149:
1142:
1141:
1139:
1138:
1133:
1127:
1125:
1118:
1117:
1115:
1114:
1109:
1103:
1101:
1094:
1093:
1091:
1090:
1085:
1079:
1077:
1070:
1069:
1067:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
990:
988:
981:
980:
977:
976:
974:
973:
968:
963:
957:
955:
948:
947:
945:
944:
939:
933:
931:
924:
923:
921:
920:
915:
910:
904:
902:
899:VEGF receptors
895:
894:
892:
891:
886:
881:
876:
870:
868:
861:
860:
858:
857:
851:
842:
837:
832:
826:
824:
818:
817:
815:
814:
809:
804:
798:
796:
789:
788:
786:
785:
780:
775:
770:
764:
762:
753:
743:
742:
736:
729:
728:
714:
712:
711:
704:
697:
689:
682:
681:
654:(5–6): 492–8.
638:
594:
539:
490:
461:(4): 513–523.
441:
412:(4): 525–535.
392:
363:(4): 513–523.
343:
314:(4): 501–512.
294:
265:(3): 573–584.
243:
241:
238:
225:
222:
193:
192:MuSK signaling
190:
161:
160:
157:
156:
151:
147:
146:
141:
137:
136:
128:
127:
117:
111:
110:
106:
105:
100:
94:
93:
88:
82:
81:
76:
70:
69:
64:
58:
57:
52:
46:
45:
42:
38:
37:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2024:
2013:
2010:
2008:
2005:
2003:
2000:
1998:
1995:
1994:
1992:
1982:
1977:
1972:
1968:
1954:
1950:
1949:
1944:
1941:
1937:
1936:
1931:
1928:
1924:
1923:
1918:
1915:
1911:
1910:
1905:
1902:
1898:
1897:
1892:
1889:
1885:
1884:
1879:
1876:
1872:
1871:
1866:
1865:
1863:
1859:
1853:
1850:
1848:
1845:
1843:
1840:
1838:
1835:
1833:
1830:
1829:
1827:
1823:
1817:
1814:
1812:
1811:Enzyme family
1809:
1807:
1804:
1802:
1799:
1798:
1796:
1792:
1786:
1783:
1781:
1778:
1776:
1775:Cooperativity
1773:
1771:
1768:
1767:
1765:
1761:
1755:
1752:
1750:
1747:
1745:
1742:
1740:
1737:
1735:
1734:Oxyanion hole
1732:
1730:
1727:
1725:
1722:
1720:
1717:
1716:
1714:
1710:
1706:
1699:
1694:
1692:
1687:
1685:
1680:
1679:
1676:
1656:
1653:
1651:
1648:
1647:
1645:
1642:
1638:
1632:
1629:
1627:
1624:
1622:
1619:
1617:
1614:
1612:
1609:
1608:
1606:
1603:
1599:
1593:
1590:
1588:
1585:
1583:
1580:
1578:
1575:
1574:
1572:
1568:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1543:
1541:
1537:
1531:
1528:
1526:
1523:
1521:
1518:
1516:
1513:
1512:
1510:
1507:
1503:
1497:
1494:
1492:
1489:
1487:
1484:
1483:
1481:
1478:
1474:
1468:
1465:
1463:
1460:
1459:
1457:
1454:
1450:
1444:
1441:
1439:
1436:
1435:
1433:
1430:
1426:
1420:
1417:
1415:
1412:
1411:
1409:
1406:
1402:
1396:
1393:
1391:
1388:
1387:
1385:
1382:
1378:
1372:
1369:
1367:
1364:
1363:
1361:
1358:
1354:
1350:
1346:(EC 2.7.10.2)
1345:
1340:
1336:
1322:
1319:
1318:
1316:
1314:uncategorised
1312:
1306:
1303:
1302:
1300:
1297:
1293:
1287:
1284:
1282:
1279:
1277:
1274:
1273:
1271:
1268:
1264:
1258:
1255:
1253:
1250:
1249:
1247:
1244:
1240:
1234:
1231:
1230:
1228:
1224:
1218:
1215:
1214:
1212:
1209:
1208:MuSK receptor
1205:
1199:
1196:
1195:
1193:
1190:
1186:
1180:
1177:
1176:
1174:
1171:
1170:PTK7 receptor
1167:
1161:
1158:
1156:
1153:
1152:
1150:
1147:
1143:
1137:
1134:
1132:
1129:
1128:
1126:
1123:
1119:
1113:
1110:
1108:
1105:
1104:
1102:
1099:
1095:
1089:
1086:
1084:
1081:
1080:
1078:
1075:
1071:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
991:
989:
986:
982:
972:
969:
967:
964:
962:
959:
958:
956:
953:
949:
943:
940:
938:
935:
934:
932:
929:
925:
919:
916:
914:
911:
909:
906:
905:
903:
900:
896:
890:
887:
885:
882:
880:
877:
875:
872:
871:
869:
866:
862:
855:
852:
850:
846:
843:
841:
838:
836:
833:
831:
828:
827:
825:
823:
819:
813:
810:
808:
805:
803:
800:
799:
797:
794:
790:
784:
781:
779:
776:
774:
771:
769:
766:
765:
763:
761:
757:
754:
752:
748:
744:
740:(EC 2.7.10.1)
739:
734:
730:
725:
721:
717:
710:
705:
703:
698:
696:
691:
690:
687:
677:
673:
669:
665:
661:
657:
653:
649:
642:
639:
634:
630:
626:
622:
618:
617:10.1038/85520
614:
610:
606:
598:
595:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
550:
543:
540:
535:
531:
526:
521:
517:
513:
509:
505:
501:
494:
491:
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469:
464:
460:
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452:
445:
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437:
433:
429:
425:
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411:
407:
403:
396:
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388:
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376:
371:
366:
362:
358:
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347:
344:
339:
335:
331:
327:
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298:
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278:
273:
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53:
51:
47:
43:
39:
34:
30:
25:
20:
1948:Translocases
1945:
1932:
1919:
1906:
1893:
1883:Transferases
1880:
1867:
1724:Binding site
1570:SRC-B family
1539:SRC-A family
1296:RET receptor
1267:AXL receptor
1216:
1207:
1189:RYK receptor
1146:DDR receptor
1122:ROR receptor
1098:TIE receptor
1074:LTK receptor
985:EPH receptor
952:Trk receptor
928:HGF receptor
865:FGF receptor
651:
647:
641:
611:(3): 365–8.
608:
604:
597:
556:
552:
542:
507:
503:
493:
458:
454:
444:
409:
405:
395:
360:
356:
346:
311:
307:
297:
262:
258:
247:
227:
195:
182:proteoglycan
169:
165:
164:
122:
1719:Active site
144:Swiss-model
36:Identifiers
1991:Categories
1922:Isomerases
1896:Hydrolases
1763:Regulation
240:References
140:Structures
135:Search for
109:Other data
1801:EC number
124:q31.3-q32
91:NM_005592
50:NCBI gene
2012:Proteins
1825:Kinetics
1749:Cofactor
1712:Activity
633:18641849
625:11231638
589:45730054
581:16794080
534:16818610
485:14930468
436:12517490
387:14930468
338:17455481
289:17575761
154:InterPro
1981:Biology
1935:Ligases
1705:Enzymes
726:2.7.10)
676:5611563
668:7838671
561:Bibcode
553:Science
525:1522076
477:8653787
428:8653788
379:8653787
330:8653786
281:7546737
204:(CK2),
184:called
172:) is a
150:Domains
98:UniProt
1967:Portal
1909:Lyases
1643:family
1604:family
1508:family
1479:family
1455:family
1431:family
1407:family
1383:family
1359:family
1298:family
1269:family
1257:AATYK2
1245:family
1210:family
1191:family
1172:family
1148:family
1124:family
1100:family
1076:family
987:family
954:family
930:family
918:VEGFR3
913:VEGFR2
908:VEGFR1
901:family
867:family
854:PDGFRB
849:PDGFRA
795:family
674:
666:
631:
623:
587:
579:
532:
522:
483:
475:
434:
426:
385:
377:
336:
328:
287:
279:
259:Neuron
210:rapsyn
120:Chr. 9
103:O15146
86:RefSeq
79:601296
41:Symbol
1861:Types
1655:ZAP70
1321:STYK1
1286:TYRO3
1252:AATYK
1059:EPHB6
1054:EPHB5
1049:EPHB4
1044:EPHB3
1039:EPHB2
1034:EPHB1
1029:EPHA8
1024:EPHA7
1019:EPHA6
1014:EPHA5
1009:EPHA4
1004:EPHA3
999:EPHA2
994:EPHA1
971:NTRK3
966:NTRK2
961:NTRK1
889:FGFR4
884:FGFR3
879:FGFR2
874:FGFR1
845:PDGFR
830:CSF1R
812:INSRR
802:IGF1R
783:ERBB4
778:ERBB3
773:ERBB2
672:S2CID
629:S2CID
585:S2CID
481:S2CID
432:S2CID
383:S2CID
334:S2CID
285:S2CID
206:Dok-7
198:agrin
186:agrin
168:(for
115:Locus
1953:list
1946:EC7
1940:list
1933:EC6
1927:list
1920:EC5
1914:list
1907:EC4
1901:list
1894:EC3
1888:list
1881:EC2
1875:list
1868:EC1
1561:YES1
1530:TYK2
1525:JAK3
1520:JAK2
1515:JAK1
1496:SRMS
1443:PYK2
1419:MATK
1395:TNK1
1390:ACK1
1366:ABL1
1233:ROS1
1217:MUSK
1179:PTK7
1160:DDR2
1155:DDR1
1136:ROR2
1131:ROR1
1064:EPHX
835:FLT3
807:INSR
768:EGFR
664:PMID
621:PMID
577:PMID
530:PMID
473:PMID
455:Cell
424:PMID
406:Cell
375:PMID
357:Cell
326:PMID
308:Cell
277:PMID
214:AChR
208:and
166:MuSK
74:OMIM
67:7525
62:HGNC
55:4593
44:MUSK
1650:SYK
1641:SYK
1631:TXK
1626:ITK
1621:BTK
1616:BMX
1611:TEC
1602:TEC
1592:LYN
1587:LCK
1582:HCK
1577:BLK
1556:FYN
1551:FGR
1546:SRC
1506:JAK
1491:BRK
1486:FRK
1477:FRK
1467:FER
1462:FES
1453:FES
1438:FAK
1429:FAK
1414:CSK
1405:CSK
1381:ACK
1371:ARG
1357:ABL
1305:RET
1281:MER
1276:AXL
1198:RYK
1112:TEK
1107:TIE
1088:ALK
1083:LTK
942:RON
937:MET
840:KIT
656:doi
652:428
613:doi
569:doi
557:312
520:PMC
512:doi
463:doi
414:doi
365:doi
316:doi
267:doi
1993::
724:EC
718::
670:.
662:.
650:.
627:.
619:.
607:.
583:.
575:.
567:.
555:.
551:.
528:.
518:.
508:20
506:.
502:.
479:.
471:.
459:85
457:.
453:.
430:.
422:.
410:85
408:.
404:.
381:.
373:.
361:85
359:.
355:.
332:.
324:.
312:85
310:.
306:.
283:.
275:.
263:15
261:.
257:.
1969::
1955:)
1951:(
1942:)
1938:(
1929:)
1925:(
1916:)
1912:(
1903:)
1899:(
1890:)
1886:(
1877:)
1873:(
1697:e
1690:t
1683:v
856:)
847:(
722:(
708:e
701:t
694:v
678:.
658::
635:.
615::
609:7
591:.
571::
563::
536:.
514::
487:.
465::
438:.
416::
389:.
367::
340:.
318::
291:.
269::
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