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Maria Manaseina

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233:, who was also interested in sleep disorders. They put ten puppies (two to four months old) under a state of permanent insomnia by keeping them constantly active. These puppies had previously been fed and well taken care of. The sleep deprivation was fatal after four to five days, leading to the death of all the puppies. As a control measure, they deprived other puppies of food. Even though they had been starving for 20–25 days, they could be rescued and returned to a healthy condition. These results clearly showed the importance of sleeping for life to be maintained and that sleep deprivation leads to a faster death than the deprivation of nutrients. Further research showed that the effects of sleep deprivation in the puppies included a body temperature decrease of 371: 283:. There, she made a noteworthy finding concerning the fermentation process, which was an important contribution to the field of biochemistry. Against the prevailing belief at that time, Manàsseina was the first to claim that the fermentation process is due to the action of enzymes that can be isolated from the yeast cells. Therefore, she concluded that yeast fermentation is a cell-independent process. 33: 20: 164:. She published numerous articles in French, Russian, and German under different names: Marie de Manacéïne, Maria Manàsseina, or Marie von Manassein. She was not uncommonly referred to as a male doctor. Despite her outstanding contributions, in the last ten years, her name has not been cited more than 100 times. 244:
in the brain. This assertion challenged the prevailing belief at that time that sleeping was merely a passive state of the organism. She also stressed that only the brain structures involved in maintaining consciousness are inactive during sleep–thus, sleeping means resting the consciousness. This
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Considering these contradictions in her biography, one can believe that Manàsseina opted for a more conservative ideology over the years. However, it is not unreasonable to think —taking into account the difficulties faced by women to establish themselves in the scientific and academic world— that
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However she was considered very conservative as an adult She provided the ministry of Education with research and information on how to control and suppress student protests and revolutionary activity. Moreover, she publicly expressed her loyalty to the tsarist government, for which she received
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ManĂ sseina was one of the first women in the Russian Empire to graduate in medicine. First, she received a special certification authorizing her as a "female doctor" and, later, the official Medicine degree certification. She is nowadays considered an expert neuroscientist in the field of
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Bassetti CL, Dijk DJ, Dogas Z, Levy P, Nobili LL, Peigneux P, et al. The Future of Sleep Research and Sleep Medicine in Europe: A Need for Academic Multidisciplinary Sleep Centres. Eur Sleep Res Soc (1972-2012) 40th  Anniv ESRS . 2012;7–8. Available from:
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replicated the results of this research and published them. Despite his being aware of Manàsseina’s work, he did not cite her nor give her any credit. Despite her efforts to obtain recognition for this discovery, it was Buchner who received a
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Maria Manàsseina wrote the first book about medical problems related to sleep. This work addresses dreams as “evidence of a permanent psychic life generated by the brain during sleep”. Nevertheless, her most outstanding publication is
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As a consequence of this research, ManĂ sseina concluded that sleeping is as necessary as nutrition for the regeneration of the brain cells. She also emphasized the idea that, during sleep, there is
425: 400: 420: 136:, was born in Korkunova in 1841 and died in Saint Petersburg on 17 March in 1903. She was buried at the Novodévitxi cemetery. Manàsseina was the daughter of 405: 279:
Though ManĂ sseina worked in Saint Petersburg the majority of her life, she spent several months at the Polytechnic Institute of Viena working alongside
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Kovalzon, V.M. (2009) Some notes on the biography of Maria ManĂ sseina. Journal Of The History Of The Neuroscience, 1744-5213, Vol. 8, Issue 3.
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Studies from the psychological laboratory of the University of Iowa: On the effects of loss of sleep, G.T.W. Patrick & J. Allen Gilbert.
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revolutionary circles, which were groups of Russian revolutionaries that appeared during 1860–70 to actively oppose and protest against the
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While still a student, ManĂ sseina married Poniatovsky, another student, whose first name is unknown. They participated alongside in the
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built upon economically autonomous entities; several towns were united to create a kind of federation to substitute the state.
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ManĂ sseina publicly conformed to the ideologies of the government to receive financial support and continue her career.
76: 271:, expanded Manàsseina’s findings by conducting detailed histopathologic and anatomic analyses of the puppies' brains. 410: 230: 83: 237:, a reduction of the number of red blood cells, local brain hemorrhages, cerebral ganglion impairment, etc. 153: 65: 43: 252: 256: 205:
Poniatovsky, her first husband, was arrested and he died during political exile. In 1856, she married
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Her work had a great impact on the scientific community and many scientists replicated her model:
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Manàsseina’s most distinguished contribution in the field of neuroscience was her research on
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http://www.esrs.eu/fileadmin/user_upload/publications/ESRS_anniversarybook_2012_e-version.pdf
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conducted the first sleep deprivation experiment on humans. In 1898, Italian investigators
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the Russian emperor, which was not overthrown until the Russian Revolution in 1917. The
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intuition is remarkable considering that the electroencephalogram didn't yet exist.
161: 19: 292: 32: 191: 174: 157: 308:(“Sleeping, a third of the human life”), which was published in 1892. 179: 229:
To conduct this investigation, she worked alongside professor
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was a philosopher. She was the disciple of the professor
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A portrait of Maria Manasseina, pioneer sleep scientist
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19th-century women scientists from the Russian Empire
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"Maria Manaseina"
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MikhaĂŻl Korkunov
Nikolai Korkunov
Ivan TarkhĂ nov
physiological chemistry
somnology
biochemistry
Narodniki
tsar
socialism
Vyacheslav Avksentievich Manassein
sleep deprivation
Ivan Romanovich Tarkhanov
George T.W. Patrick
J. Allen Gilbert
Lamberto Daddi
Giulio Tarozzi
Cesare Agostini
Jullius Wiesner

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