173:, was first documented in a 2011 article co-authored by Michelle Harvie, Mattson, and 14 additional scientists. The 5:2 does not follow a particular food pattern, but instead focuses entirely on calorie content. In other words, two days of the week are devoted to consumption of approximately 500 to 600 calories, or about 25% of regular daily caloric intake, with normal calorie intake during the other five days of the week. The diet was later popularized in the UK and Australia by
31:
935:
This story, which was originally written by Pamela Wilson and published by ABC Health and
Wellbeing, has been reviewed by Dr Rosemary Stanton OAM, nutritionist and visiting fellow, School of Medical Sciences, University of NSW, and was updated in 2019. Posted 5 Feb 2020, updated 10 Feb
199:
for research revealing the cellular mechanisms involved in neural plasticity β the ability of neurons to adapt during processes like learning or injury β and development of neurodegenerative disorders. He is the recipient of the
849:
145:. The National Institute of Health considers him "one of the worldβs top experts on the potential cognitive and physical health benefits of intermittent fasting". He is author of the book
196:
892:
204:
Zenith Award, the
Metropolitan Life Foundation Medical Research Award, and the Santiago Grisolia Chair Prize. He was as the founding editor and editor-in-chief of
262:
Furukawa K, Barger SW, Blalock E, Mattson MP (1996). "Activation of K+ channels and suppression of neuronal activity by secreted Ξ²-amyloid precursor protein".
744:"The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomised trial in young overweight women"
183:
149:. Mattson's research has also elucidated roles for the neurotransmitter glutamate in neuroplasticity and Alzheimer's disease. He is the author of the book
83:
1015:
1000:
985:
662:
217:
On June 3, 2019, the international symposium
Pathways towards and away from Brain Health was held to honor him on his retirement from the NIH.
995:
915:
923:
620:
1010:
245:
134:
Mattson is the former chief of the
Laboratory of Neurosciences at the National Institute on Aging Intramural Research Program of the
980:
562:
748:
99:
187:(in which he learned about the 5:2 diet from Mattson who also appeared in the documentary). It also became common in Australia.
590:
888:
401:
Cheng A, Yang Y, Zhou Y, Maharana C, Lu D, Peng W, Liu Y, Wan R, Marosi K, Misiak M, Bohr VA, Mattson MP (January 2016).
990:
866:
135:
201:
403:"Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise, and metabolic and excitatory challenges"
123:
115:
63:
52:
607:
one of the world's top experts on the potential cognitive and physical health benefits of intermittent fasting
724:
487:
de Cabo RE, Mattson MP (December 26, 2019). "Effects of intermittent fasting on health, aging, and disease".
210:
813:
1005:
111:
47:
320:
271:
170:
157:
called Brain
Ponderings, on which he interviews prominent neuroscientists about their life and work.
142:
679:
830:
638:
542:
512:
295:
119:
58:
801:
The
Intermittent Fasting Revolution: The Science of Optimizing Health and Enhancing Performance
234:
The
Intermittent Fasting Revolution: The Science of Optimizing Health and Enhancing Performance
147:
The
Intermittent Fasting Revolution: The Science of Optimizing Health and Enhancing Performance
955:
775:
504:
475:
432:
389:
346:
287:
241:
765:
757:
628:
496:
465:
457:
422:
414:
379:
371:
336:
328:
279:
538:
965:
324:
275:
151:
Sculptor and
Destroyer: Tales of Glutamate - the Brain's Most Important Neurotransmitter
770:
743:
470:
445:
427:
402:
384:
359:
341:
308:
174:
711:
Sculptor and
Destroyer: Tales of Glutamate the Brain's Most Important Neurotransmitter
974:
642:
516:
299:
960:
826:
118:(originally North Texas State University) in 1982, and his Ph.D. in Biology at the
98:
is an American neuroscientist who is an adjunct professor of neuroscience at the
418:
633:
237:
862:
779:
508:
479:
436:
393:
350:
500:
360:"Recruiting adaptive cellular stress responses for successful brain aging"
291:
30:
761:
461:
332:
951:
154:
591:"International Symposium to Honor Pioneer in Neuroscience and Fasting"
444:
Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng AE (February 2018).
283:
446:"Intermittent metabolic switching, neuroplasticity and brain health"
375:
663:"Fasting power: Can going without food really make you healthier?"
563:"Speakers: Neuroplasticity, Neuroregeneration, and Brain Repair"
916:"What the science says about the 5:2 intermittent fasting diet"
178:
621:"The when of eating: The science behind intermittent fasting"
850:
Michael Mosley: βNo male in my family has made it beyond 72
309:"Pathways towards and away from Alzheimer's disease"
197:
American Association for the Advancement of Science
79:
40:
21:
122:in 1986. He was then a postdoctoral fellow at
8:
84:Johns Hopkins University School of Medicine
803:. MIT Press. p. 198 (Kindle edition).
110:Mattson received his B.S. in Zoology from
18:
769:
632:
585:
583:
581:
579:
469:
426:
383:
340:
742:; Frystyk, Jan; Dillon, Bernice (2011).
619:von Bubnoff, Andreas (29 January 2021).
791:
789:
530:
55:(Originally N. Texas State University)
889:"Horizon - Eat, Fast and Live Longer"
869:from the original on 16 February 2019
7:
195:Mattson was elected a Fellow of the
924:Australian Broadcasting Corporation
895:from the original on 5 January 2019
863:"The power of intermittent fasting"
738:Harvie, Michelle; Pegington, Mary;
696:The Intermittent Fasting Revolution
565:. The New York Academy of Sciences
14:
825:Marengo, Katherine (2019-01-28).
358:Stranahan AM, Mattson MP (2012).
1016:University of North Texas alumni
1001:Johns Hopkins University faculty
986:Colorado State University alumni
749:International Journal of Obesity
114:in 1979, his M.S. in Biology at
100:Johns Hopkins School of Medicine
29:
891:. BBC iPlayer. 6 August 2012.
1:
914:Wilson P (10 February 2020).
141:Mattson has done research on
996:Iowa State University alumni
725:"BRAIN PONDERINGS podcasts"
595:National Institute on Aging
136:National Institute on Aging
1032:
861:Mosley M (5 August 2012).
419:10.1016/j.cmet.2015.10.013
307:Mattson MP (August 2004).
1011:University of Iowa alumni
684:Thursday, October 1, 2020
634:10.1146/knowable-012821-1
256:Selected journal articles
184:Eat, Fast and Live Longer
124:Colorado State University
116:University of North Texas
89:
72:
64:Colorado State University
53:University of North Texas
28:
981:American neuroscientists
827:"How to do the 5:2 diet"
106:Early life and education
961:Johns Hopkins biography
814:Does the 5:2 diet work?
211:Ageing Research Reviews
206:NeuroMolecular Medicine
202:Alzheimer's Association
16:American neuroscientist
709:Mattson, Mark (2023).
694:Mattson, Mark (2022).
232:Mattson, Mark (2022).
191:Awards and recognition
501:10.1056/NEJMra1905136
221:Selected publications
112:Iowa State University
48:Iowa State University
762:10.1038/ijo.2010.171
462:10.1038/nrn.2017.156
171:intermittent fasting
143:intermittent fasting
35:Mark Mattson in 2009
991:Fasting researchers
966:MIT Press biography
333:10.1038/nature02621
325:2004Natur.430..631M
276:1996Natur.379...74F
831:Medical News Today
543:University of Iowa
153:. He also hosts a
120:University of Iowa
59:University of Iowa
625:Knowable Magazine
93:
92:
74:Scientific career
1023:
939:
938:
932:
930:
911:
905:
904:
902:
900:
885:
879:
878:
876:
874:
858:
852:
847:
841:
840:
838:
837:
822:
816:
811:
805:
804:
793:
784:
783:
773:
735:
729:
728:
727:. 10 March 2023.
721:
715:
714:
706:
700:
699:
691:
685:
683:
676:
670:
660:
654:
653:
651:
649:
636:
616:
610:
609:
604:
602:
587:
574:
573:
571:
570:
559:
553:
552:
550:
549:
535:
520:
483:
473:
450:Nat Rev Neurosci
440:
430:
397:
387:
364:Nat Rev Neurosci
354:
344:
303:
284:10.1038/379074a0
251:
177:though the 2012
33:
19:
1031:
1030:
1026:
1025:
1024:
1022:
1021:
1020:
971:
970:
948:
943:
942:
928:
926:
913:
912:
908:
898:
896:
887:
886:
882:
872:
870:
860:
859:
855:
848:
844:
835:
833:
824:
823:
819:
812:
808:
795:
794:
787:
737:
736:
732:
723:
722:
718:
708:
707:
703:
693:
692:
688:
680:"Fasting Guide"
678:
677:
673:
661:
657:
647:
645:
618:
617:
613:
600:
598:
589:
588:
577:
568:
566:
561:
560:
556:
547:
545:
537:
536:
532:
527:
495:(26): 2541β51.
486:
443:
400:
376:10.1038/nrn3151
357:
319:(7000): 631β9.
306:
261:
258:
248:
231:
228:
223:
193:
163:
132:
108:
96:Mark P. Mattson
68:
41:Alma mater
36:
24:
17:
12:
11:
5:
1029:
1027:
1019:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
973:
972:
969:
968:
963:
958:
947:
946:External links
944:
941:
940:
906:
880:
865:. BBC Health.
853:
842:
817:
806:
785:
756:(5): 714β727.
730:
716:
701:
686:
671:
655:
611:
597:. May 29, 2019
575:
554:
539:"Mark Mattson"
529:
528:
526:
523:
522:
521:
484:
441:
398:
355:
304:
270:(6560): 74β8.
257:
254:
253:
252:
247:978-0262046404
246:
227:
224:
222:
219:
192:
189:
175:Michael Mosley
162:
159:
131:
128:
107:
104:
91:
90:
87:
86:
81:
77:
76:
70:
69:
67:
66:
61:
56:
50:
44:
42:
38:
37:
34:
26:
25:
22:
15:
13:
10:
9:
6:
4:
3:
2:
1028:
1017:
1014:
1012:
1009:
1007:
1006:Living people
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
978:
976:
967:
964:
962:
959:
957:
953:
950:
949:
945:
937:
925:
921:
917:
910:
907:
894:
890:
884:
881:
868:
864:
857:
854:
851:
846:
843:
832:
828:
821:
818:
815:
810:
807:
802:
798:
797:Mattson, Mark
792:
790:
786:
781:
777:
772:
767:
763:
759:
755:
751:
750:
745:
741:
740:Mattson, Mark
734:
731:
726:
720:
717:
712:
705:
702:
697:
690:
687:
681:
675:
672:
668:
667:New Scientist
664:
659:
656:
644:
640:
635:
630:
626:
622:
615:
612:
608:
596:
592:
586:
584:
582:
580:
576:
564:
558:
555:
544:
540:
534:
531:
524:
518:
514:
510:
506:
502:
498:
494:
490:
485:
481:
477:
472:
467:
463:
459:
456:(26): 63β80.
455:
451:
447:
442:
438:
434:
429:
424:
420:
416:
413:(1): 128β42.
412:
408:
404:
399:
395:
391:
386:
381:
377:
373:
370:(3): 209β16.
369:
365:
361:
356:
352:
348:
343:
338:
334:
330:
326:
322:
318:
314:
310:
305:
301:
297:
293:
289:
285:
281:
277:
273:
269:
265:
260:
259:
255:
249:
243:
239:
235:
230:
229:
225:
220:
218:
215:
213:
212:
207:
203:
198:
190:
188:
186:
185:
180:
176:
172:
168:
160:
158:
156:
152:
148:
144:
139:
137:
129:
127:
125:
121:
117:
113:
105:
103:
101:
97:
88:
85:
82:
78:
75:
71:
65:
62:
60:
57:
54:
51:
49:
46:
45:
43:
39:
32:
27:
20:
952:Mark Mattson
934:
927:. Retrieved
920:ABC Everyday
919:
909:
897:. Retrieved
883:
871:. Retrieved
856:
845:
834:. Retrieved
820:
809:
800:
796:
753:
747:
739:
733:
719:
713:. MIT Press.
710:
704:
698:. MIT Press.
695:
689:
674:
666:
658:
646:. Retrieved
624:
614:
606:
599:. Retrieved
594:
567:. Retrieved
557:
546:. Retrieved
533:
492:
489:N Engl J Med
488:
453:
449:
410:
406:
367:
363:
316:
312:
267:
263:
233:
216:
209:
205:
194:
182:
181:documentary
166:
164:
150:
146:
140:
133:
109:
95:
94:
80:Institutions
73:
23:Mark Mattson
929:11 February
648:29 November
601:January 11,
975:Categories
899:14 January
873:14 January
836:2023-10-08
569:2023-10-08
548:2023-10-08
525:References
407:Cell Metab
169:a form of
643:234087270
517:209498984
238:MIT Press
167:5:2 diet,
893:Archived
867:Archived
799:(2022).
780:20921964
509:31881139
480:22251954
437:26698917
394:22251954
351:15295589
300:25513373
161:5:2 diet
771:3017674
471:5913738
428:5141613
385:4084510
342:3091392
321:Bibcode
292:8538744
272:Bibcode
155:podcast
778:
768:
641:
515:
507:
478:
468:
435:
425:
392:
382:
349:
339:
313:Nature
298:
290:
264:Nature
244:
130:Career
639:S2CID
513:S2CID
296:S2CID
956:IMDb
936:2020
931:2021
901:2019
875:2019
776:PMID
650:2021
603:2020
505:PMID
476:PMID
433:PMID
390:PMID
347:PMID
288:PMID
242:ISBN
226:Book
208:and
165:The
954:at
766:PMC
758:doi
629:doi
497:doi
493:381
466:PMC
458:doi
423:PMC
415:doi
380:PMC
372:doi
337:PMC
329:doi
317:430
280:doi
268:379
179:BBC
977::
933:.
922:.
918:.
829:.
788:^
774:.
764:.
754:35
752:.
746:.
665:.
637:.
627:.
623:.
605:.
593:.
578:^
541:.
511:.
503:.
491:.
474:.
464:.
454:19
452:.
448:.
431:.
421:.
411:23
409:.
405:.
388:.
378:.
368:13
366:.
362:.
345:.
335:.
327:.
315:.
311:.
294:.
286:.
278:.
266:.
240:.
236:.
214:.
138:.
126:.
102:.
903:.
877:.
839:.
782:.
760::
682:.
669:.
652:.
631::
572:.
551:.
519:.
499::
482:.
460::
439:.
417::
396:.
374::
353:.
331::
323::
302:.
282::
274::
250:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
