170:. The university did not disclose reasons for the dismissal, but members of the Huntsman family issued several public criticisms of the move, and called for Beckerle's reinstatement while criticizing the leadership shown by Pershing and Lee. In subsequent days, members of the family made media appearances, published full page newspaper ads reiterating their support for cancer research and Beckerle, and even called for the termination of top university officials. Beckerle's firing occurred as the University of Utah and Huntsman Cancer Foundation were negotiating terms for a new memorandum of understanding to govern the operations of Huntsman Cancer Institute. Some Huntsman Cancer Institute faculty and staff were among over 3600 individuals who signed a petition requesting Beckerle be restored to her position. On 19 April, roughly 100 demonstrators marched from the Huntsman Cancer Institute facilities across the university campus to the Office of President Pershing, calling for Beckerle's return. This came on the heels of other meetings and protests in the university community. On the morning of 25 April, the university's board of trustees met in a closed session, after which Pershing briefly spoke to reporters, mentioning that an announcement would be forthcoming later in the day. Within a few hours, it was announced that Beckerle would be reinstated as CEO and Director of the Huntsman Cancer Institute, and would report directly to the University President, bypassing Vivian Lee. On 28 April, Vivian Lee announced via email that, effective the same day, she was stepping down as the university's senior vice president for health sciences, dean of the medical school, and CEO of the healthcare system.
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mechanism by which the cancer cells can spread. Ewing sarcoma occurs due to a chromosomal mutation that causes an atypical protein, known as EWS/FLI, to be present (also called expressed), and that when EWS/FLI is expressed, literally thousands of genes are misregulated, leading to abnormal behavior. Beckerle's lab found that the EWS/FLI protein disrupted cell adhesion and limited the ability of cells to remain in their normal environment. The EWS/FLI protein is difficult to regulate so
Beckerle's team is focused on an essential regulating protein called lysine specific demethylase (LSD1). Preliminary research has aimed to halt the function of LSD1 to prevent the spread of Ewing Sarcoma cells.
123:
Endowed Chair in Cancer
Research at the University of Utah. She led a program specializing in cancer cell biology until 2003. In 2003, she was named the deputy director of the center. In 2006, she was named the CEO and the director of Huntsman Cancer Institute. In 2009, she was also named the Associate Vice President for Cancer Affairs at the University of Utah. She holds the Jon M. Huntsman Presidential Endowed Chair at the University of Utah, where she has also been promoted to a distinguished professorship in the biology department.
31:
65:, a pediatric bone cancer. Beckerle's lab made a ground breaking discovery in regards to Ewing's Sarcoma in relation to the EWS/FLI protein. Her lab discovered EWS/FLI to disrupt the internal cellular skeleton, which decreases the ability of cells to adhere to their proper environment. This can help explain the metastasis of tumors in patients with Ewing's sarcoma.
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Beckerle joined the
University of Utah faculty as an assistant professor of biology. She continued at the University of Utah and was one of the first professors to move into the Huntsman Cancer Institute when it opened in 1999. Also in 1999, she was awarded the Ralph E. and Willa T. Main Presidential
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issues. Ewing's
Sarcoma is a bone cancer affecting mainly children and adolescents. Tumors of Ewing' Sarcoma are typically found in the long bones of the legs and arms, or bones in the chest, trunk, pelvis, back, or head. Beckerle's research in this area focuses on a key pathway as believed to be a
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Newly elected members and their affiliations at the time of election are: ... Beckerle, Mary C.; chief executive officer and director, Huntsman Cancer
Institute; and distinguished professor of biology and associate vice president for cancer affairs, University of Utah, Salt Lake
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of the cell. She was awarded a
Guggenheim Fellowship in Molecular and Cellular Biology at the Curie Institute in Paris in 1999. In 2006, Beckerle served as the president of the American Society of Cell Biology. She was elected to the
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Mary
Catherine Beckerle was born in Rivers Edge, New Jersey to Martin and Mickey Beckerle. She is the oldest of three daughters. Her father worked at the New York Telephone Co. and died at the age of 36 of
57:. At Huntsman Cancer Institute, she serves as the CEO and also as Associate Vice President for Cancer Affairs at the University of Utah. Beckerle's research helped to define a novel molecular pathway for
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238:"Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants"
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On 17 April 2017, Beckerle was terminated as CEO and
Director of the Huntsman Cancer Institute via an email from University of Utah President
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in 2008. In 2013, she was elected to the Board of
Directors of the American Association for Cancer Research. Beckerle was elected to the
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Benson, Lee, “They all want what
Huntsman has — The woman in charge”. Deseret News. March 1, 2014. Accessed November 11, 2014.
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Neufield, Erica. “Huntsman Cancer Institute Awarded Grant for Children's Cancer Research” CureSearch for Children’s Cancer.
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777:"Huntsman says University of Utah 'power grab' is behind firing of acclaimed researcher from cancer institute top post"
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90:. Before continuing her education, she took a year off and worked in a cellular biology research laboratory at
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791:"Huntsman Sr. Blasts the U. For firing of Cancer Institute director, says there is 'no excuse' for it"
432:"The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma"
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805:"Huntsman calls for 'inept' U. Administrators to be fired over cancer institute CEO's termination"
633:"Mary C. Beckerle, PhD - Faculty Details - U of U School of Medicine - | University of Utah"
555:"Huntsman Cancer Institute Investigator Awarded Grant for Children's Cancer Research: CureSearch"
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819:"Emails explain clash between Huntsmans and the U. Over Huntsman Cancer Institute CEO's firing"
283:"Lateral communication between stress fiber sarcomeres facilitates a local remodeling response"
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Smith, MA; Blankman, E; Deakin, NO; Hoffman, LM; Jensen, CC; Turner, CE; Beckerle, MC (2013).
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Boulder where she earned a PhD. in Molecular Biology. Her education then continued at the
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Beckerle's research employs several different techniques to exam signaling problems and
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in New York, where she earned a B. A. in Biology and Psychology. She graduated
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Chapel Hill where she was a postdoctoral fellow in Anatomy and Cell Biology.
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847:"U. Health Care CEO Vivian Lee resigns after cancer institute controversy"
78:. Her mother was a registered nurse. After high school, Beckerle attended
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Chaturvedi, A; Hoffman, LM; Welm, AL; Lessnick, SL; Beckerle, MC (2012).
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Hoffman, LM; Jensen, CC; Chaturvedi, A; Yoshigi, M; Beckerle, MC (2012).
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Elias, MC; Pronovost, SM; Cahill, KJ; Beckerle, MC; Kadrmas, JL (2012).
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833:"In major reversal, U. Reinstates fired Huntsman Cancer Institute CEO"
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Chapin, LM; Blankman, E; Smith, MA; Shiu, YT; Beckerle, MC (2012).
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195:"How cell biologists can contribute to improving cancer outcomes"
647:"John Simon Guggenheim Foundation | Mary C. Beckerle"
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Members of the United States National Academy of Sciences
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in the April 2017 group of inductees that also included
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2017 Huntsman Cancer Institute firing and reinstatement
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Southwest Medical Center. After this, she attended the
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861:"Dr. Vivian Lee resigns post at University of Utah"
126:In 1990, Beckerle served on the editorial board of
236:Pronovost, SM; Beckerle, MC; Kadrmas, JL (2013).
61:, and more recently, she has begun research into
678:. American Philosophical Society. Archived from
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933:Biologists from New York (state)
918:21st-century American biologists
137:American Philosophical Society
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150:She is a member of the U. S.
672:"Newly Elected – April 2017"
500:10.1371/journal.pone.0069378
255:10.1371/journal.pgen.1003406
174:Research and Ewing’s Sarcoma
152:National Academy of Sciences
100:University of North Carolina
728:"Infosys Prize - Jury 2020"
708:. Deseret News. 22 May 2017
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211:10.1091/mbc.e10-05-0423
27:American cell biologist
885:Ewing’s Sarcoma. WebMD
96:University of Colorado
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193:Beckerle, MC (2010).
187:Selected publications
34:Mary Beckerle in 2012
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682:on 15 September 2017
86:and was a member of
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92:University of Texas
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346:(Pt 13): 3185–94.
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535:References
340:J Cell Sci
287:Biophys. J
242:PLOS Genet
168:Vivian Lee
69:Early life
147:in 2020.
76:emphysema
527:18689737
519:23990882
479:PLOS ONE
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