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Fuchter is interested in how considerations of chirality can be applied to the development of novel approaches in chiral optoelectronic materials and devices. In particular, he focusses on the introduction of chiral-optical (so-called chiroptical) properties into optoelectronic materials. Amongst
634:
Dembélé, Laurent; Franetich, Jean-François; Lorthiois, Audrey; Gego, Audrey; Zeeman, Anne-Marie; Kocken, Clemens H. M.; Le Grand, Roger; Dereuddre-Bosquet, Nathalie; van Gemert, Geert-Jan; Sauerwein, Robert; Vaillant, Jean-Christophe (2014). "Persistence and activation of malaria hypnozoites in
335:, which are devices that are capable of detecting circularly polarised light. As well as using chiral functional materials for light emission and detection, Fuchter has investigated the charge transport properties of enantiopure and racemic chiral functional materials.
361:
and develops small molecule ligands that can either inhibit or stimulate the activity of disease relevant proteins. While he has worked on many drug targets, he has specialised in proteins involved in the transcriptional and
680:
Gerkman, Mihael A.; Gibson, Rosina S. L.; Calbo, JoaquĂn; Shi, Yuran; Fuchter, Matthew J.; Han, Grace G. D. (2020). "Arylazopyrazoles for Long-Term
Thermal Energy Storage and Optically Triggered Heat Release below 0 °C".
391:(CDK7), a transcriptional regulatory protein that also regulates the cell cycle. Certain cancers rely on CDK7, so inhibition of this enzyme has potential to have a significant impact on cancer pathogenesis.
338:
Fuchter has also developed novel molecular photoswitches – molecules that can be cleanly and reversibly interconverted between two states using light – with a focus on heteroaromatic versions of
1167:
342:. The arylazopyrazole switches developed by Fuchter out perform the ubiquitous azobenzene switches, demonstrating complete photoswitching in both directions and thermal half-lives of the
203:. His research focuses on the development and application of novel functional molecular systems to a broad range of areas; from materials to medicine. He has been awarded both the
736:
Yang, Ying; da Costa, Rosenildo Correa; Fuchter, Matthew J.; Campbell, Alasdair J. (2013). "Circularly polarized light detection by a chiral organic semiconductor transistor".
239:, where he was awarded the Richard Dixon prize. It was during his undergraduate degree that he first became interested in organic synthesis. As a graduate student he moved to
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Cherblanc, Fanny L; Chapman, Kathryn L; Brown, Robert; Fuchter, Matthew J (2013). "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases".
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531:"Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum"
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791:"Induction of Circularly Polarized Electroluminescence from an Achiral Light-Emitting Polymer via a Chiral Small-Molecule Dopant"
441:
204:
81:
842:"Circularly Polarized Phosphorescent Electroluminescence with a High Dissymmetry Factor from PHOLEDs Based on a Platinahelicene"
379:
In 2018 one of the cancer drugs developed by
Fuchter, together with Anthony Barrett, Simak Ali and Charles Coombes entered a
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isomer of up to 46 years. Fuchter continues to apply these switches to a range of photoaddressable applications from
311:
in 2015 and
Professor in 2019. Fuchter develops photoswitchable molecules, chiral materials and new pharmaceuticals.
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Yang, Ying; Costa, Rosenildo Correa da; Smilgies, Detlef-M.; Campbell, Alasdair J.; Fuchter, Matthew J. (2013).
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1462:"The Chiral Materials Team - 2022 Materials Chemistry Division Horizon Prize: Stephanie L Kwolek Award winner"
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1220:"Imperial-developed cancer drug enters phase I clinical trial – NIHR Imperial Biomedical Research Centre"
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2017 Imperial
College London President’s Medal for Excellence in Innovation and Entrepreneurship
228:
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Brandt, Jochen R.; Wang, Xuhua; Yang, Ying; Campbell, Alasdair J.; Fuchter, Matthew J. (2016).
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these materials, Fuchter has extensively evaluated the use of chiral small molecule additives (
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Synthetic studies on porphyrazines : biological applications and new preparative methods
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1244:"Introducing MedChemComm Associate Editor Dr Matthew Fuchter – RSC Medicinal Chemistry Blog"
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processes of disease. A particular interest has been the development of inhibitors for the
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Synthetic studies on porphyrazines: biological applications and new preparative methods
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331:. He has also investigated the application of such materials in circularly polarised
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1193:"Novel Antimalarial Drugs Through Epigenetics: Full Interview with Dr Matt Fuchter"
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Malmquist, N. A.; Moss, T. A.; Mecheri, S.; Scherf, A.; Fuchter, M. J. (2012).
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Biological and
Medicinal Chemistry Sector Malcolm Campbell Memorial Prize
398:
as a
Professor of Chemistry and the Sydney Bailey Fellow in Chemistry at
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1144:"The central science: using molecules to develop materials and medicine"
383:, and as of 2020, it is in phase 2. The drug, which was designed using
252:
44:
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Alongside his work on functional material discovery, Fuchter works in
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255:. During his doctoral studies Barrett and Fuchter collaborated with
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958:"Interview with Matthew J. Fuchter - SYNFORM - Thieme Chemistry"
328:
1341:"Five Imperial academics win Royal Society of Chemistry awards"
1438:"Professor Matthew Fuchter | 2021 Corday-Morgan Prize winner"
199:
is a
British chemist who is a Professor of Chemistry at the
1116:"Introducing chirality to give organic electronics a twist"
303:). Less than one year later he was appointed a Lecturer at
1414:"Matthew Fuchter | Blavatnik Awards for Young Scientists"
1365:"Matt Fuchter wins Tetrahedron Young Investigator Award"
295:, where he began his independent academic career at the
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104:
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63:
55:
35:
21:
481:Engineering and Physical Sciences Research Council
424:organic division. Fuchter is co-Director of the
535:Proceedings of the National Academy of Sciences
1317:"Harrison-Meldola Memorial Prize Winner 2014"
8:
464:President's Award for Excellence in Research
271:After completing his PhD, Fuchter moved to
181:
18:
1568:Fellows of the Royal Society of Chemistry
1022:
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420:. He is an elected council member of the
1511:"Members - European Academy of Sciences"
1297:LMS London Institute of Medical Sciences
846:Journal of the American Chemical Society
683:Journal of the American Chemical Society
635:long-term primary hepatocyte cultures".
450:of the Royal Society of Chemistry (FRSC)
319:) to induce chiroptical properties into
297:School of Pharmacy, University of London
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1084:"Chemistry Tree - Anthony GM Barrett"
952:
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517:European Academy of Sciences and Arts
488:Blavatnik Awards for Young Scientists
483:(EPSRC) Established career fellowship
376:parasite that causes human malaria.
247:on the synthesis and applications of
217:Blavatnik Awards for Young Scientists
86:Blavatnik Awards for Young Scientists
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1056:(PhD thesis). University of London.
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215:. In 2020 he was a finalist for the
1548:Alumni of the University of Bristol
428:Centre for Drug Discovery Science.
1269:"Organic Division Council Members"
291:. In 2007 Fuchter returned to the
14:
1553:Alumni of Imperial College London
1487:"Malcolm Campbell Memorial Prize"
1390:"Matthew Fuchter - EPSRC website"
625:
368:histone-lysine methyltransferase
1114:Newton, Jennifer (2020-04-29).
442:Harrison-Meldola Memorial Prize
323:for the realisation of chiral (
205:Harrison-Meldola Memorial Prize
82:Harrison-Meldola Memorial Prize
1046:Fuchter, Matthew John (2006).
1:
1005:Zanda, Matteo (2015-10-20).
309:Reader (Associate Professor)
982:"Prof. A.G.M. Barrett, FRS"
515:2023 Elected Fellow of the
394:In 2024 Fuchter joined the
307:, where he was promoted to
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1466:Royal Society of Chemistry
1442:Royal Society of Chemistry
510:Royal Society of Chemistry
503:Royal Society of Chemistry
494:Royal Society of Chemistry
439:Royal Society of Chemistry
422:Royal Society of Chemistry
213:Royal Society of Chemistry
1371:. Imperial College London
505:Stephanie L. Kwolek Award
457:Chemistry Journal Awardee
455:Thieme Medical Publishers
400:St Peter’s College Oxford
389:cyclin-dependent kinase 7
156:
117:University College London
97:
758:10.1038/nphoton.2013.176
476:Young Investigator Award
223:Early life and education
1148:Imperial College London
1007:"Synform Issue 2015/11"
592:Nature Chemical Biology
556:10.1073/pnas.1205414109
462:Imperial College London
426:Imperial College London
385:computational chemistry
321:light emitting polymers
305:Imperial College London
287:, where he worked with
285:University of Melbourne
261:Northwestern University
243:, where he worked with
241:Imperial College London
113:Imperial College London
109:University of Melbourne
72:Imperial College London
1024:10.1055/s-0035-1560202
807:10.1002/adma.201204961
410:Fuchter serves on the
381:phase 1 clinical trial
301:UCL School of Pharmacy
1485:Williamson, Douglas.
604:10.1038/nchembio.1187
523:Selected publications
277:postdoctoral research
237:University of Bristol
68:University of Bristol
859:10.1021/jacs.6b02463
695:10.1021/jacs.0c00374
396:University of Oxford
325:circularly polarised
209:Corday–Morgan Prizes
201:University of Oxford
192:Matthew John Fuchter
121:University of Oxford
40:Matthew John Fuchter
1563:Medicinal chemistry
1418:blavatnikawards.org
1293:"Associated Groups"
1172:Apollo Therapeutics
750:2013NaPho...7..634Y
547:2012PNAS..10916708M
541:(41): 16708–16713.
497:Corday–Morgan Prize
359:medicinal chemistry
289:Andrew Bruce Holmes
267:Research and career
91:Corday–Morgan Prize
1120:chemistryworld.com
795:Advanced Materials
432:Awards and honours
253:therapeutic agents
1017:(21): A150–A166.
915:www.chem.ox.ac.uk
911:"Matthew Fuchter"
852:(31): 9743–9746.
801:(18): 2624–2628.
689:(19): 8688–8695.
348:photopharmacology
227:Fuchter earned a
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