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principle, i.e., a substance that is released in the body by a metabolic modification from precursors, which are pharmacologically active. According to B.J. Hagwood, Rocha e Silva's biographer, "The discovery of bradykinin has led to a new understanding of many physiological and pathological
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Rocha e Silva had many interests besides scientific research and pharmacology. He was an accomplished amateur painter and a writer of fiction and non-fiction. He was interested in the
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167:(AAAS) counterparts. He was to become three times president of SBPC and its lifetime honorary president. Rocha e Silva was also a founding member of the
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Rocha e Silva was one of the greatest scientific and academic leaders of recent history in Brazil. In 1948, with a group of fellow scientists, such as
179:(the highest scientific decoration at the time in Brazil) as well as the National Award of Science and Technology from the National Research Council (
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88:), lecturing in high schools while he was a student in order to support himself. Shortly after graduation he moved in 1937 to
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The practical importance of the discovery of bradykinin became apparent when one of his collaborators at Ribeirão Preto,
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related to the toxicology of snake bites, started by Rocha e Silva as early as 1939. Bradykinin was to be proved a new
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252:(BPF) in the bothropic venom which increases powerfully both the duration and magnitude of its effects on
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159:(SBPC – Brazilian Society of the Advancement of Science), similar in scope and philosophy to its
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in animal preparations. Bradykinin was detected in the plasma of animals after the addition of
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Mauricio Rocha e Silva MD: snake venom, bradykinin and the rise of autopharmacology
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326:. Brazilian Institute of Science and Technology (in Portuguese). (Dead Link)
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116:. At the Institute, he was soon appointed as the chairman of the Section of
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80:, João Olavo da Rocha e Silva. He studied at the Faculty of Medicine of the
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scientists developed the first of a new generation of highly-effective
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225:, Brazil. This discovery was part of a continuing study on circulatory
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phenomena including circulatory shock induced by venoms and toxins."
217:(Brazilian lancehead snake), which was brought by Rosenfeld from the
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276:(trademarked Capoten), which have been saving many lives since.
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Brazilian
Society of Pharmacology and Experimental Therapeutics
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control and many other phenomena related to the contraction of
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to go to London, England, where he studied and worked with
33:) was a Brazilian physician, biomedical scientist and
289:Brazilian Society for the Advancement of Science
157:Sociedade Brasileira para o Progresso da Ciência
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355:Members of the Brazilian Academy of Sciences
365:Federal University of Rio de Janeiro alumni
98:John Simon Guggenheim Memorial Foundation
324:Remarkable Persons in Brazilian Science
183:). He was also a vice-president of the
126:Faculty of Medicine of Ribeirão Preto
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86:Federal University of Rio de Janeiro
185:International Union of Pharmacology
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260:. On the basis of this finding,
287:", the science magazine of the
281:public understanding of science
169:Brazilian Society of Physiology
76:Rocha e Silva was the son of a
19:Maurício Oscar da Rocha e Silva
360:University of São Paulo alumni
250:bradykinin potentiating factor
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256:and the consequent fall in
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350:Brazilian pharmacologists
195:Together with colleagues
112:in the effects of animal
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318:Barros de Carvalho, R.:
308:1997 Nov;35(11):1569–80.
246:Sérgio Henrique Ferreira
370:Brazilian physiologists
266:anti-hypertensive drugs
197:Wilson Teixeira Beraldo
130:University of São Paulo
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320:Maurício Rocha e Silva
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177:Moinho Santista Award
94:Biological Institute
82:University of Brazil
25:– 19 December 1983,
21:(19 September 1910,
238:autopharmacological
219:Butantan Institute
285:Ciência e Cultura
214:Bothrops jararaca
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78:psychiatrist
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345:1983 deaths
340:1910 births
231:proteolytic
136:, state of
46:polypeptide
334:Categories
272:, such as
205:bradykinin
50:physiology
43:endogenous
39:bradykinin
274:captopril
223:São Paulo
145:José Reis
138:São Paulo
110:histamine
90:São Paulo
58:pathology
291:(SBPC).
165:American
306:Toxicon
234:enzymes
161:British
128:of the
104:at the
84:(later
262:Squibb
114:venoms
31:Brazil
227:shock
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