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Max Delbrück

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scientists in part for this work. To put this work in its historical perspective, Lamarck in 1801 first presented his theory of Inheritance of Acquired Characteristics, which stated that if an organism changes during life in order to adapt to its environment (for example stretches its neck to reach for tall trees), those changes are passed on to its offspring. He also said that evolution happens according to a predetermined plan. Darwin published his theory of evolution in his 1859 book On the Origin of Species with compelling evidence contradicting Lamarck. Darwin said that evolution is not predetermined but that there are inherent variations in all organisms, and that those variations that confer increased fitness are selected by the environment and passed on to the offspring. In the feud between Lamarck and Darwin, Darwin talked of pre-existing changes, but the nature of these changes was not known and had to await the science of genetics by Gregor Mendel's experiments on pea plants published in 1866. Support for Darwin's theory was provided when Thomas Hunt Morgan discovered that a mutated white-eyed fruit fly among red-eyed flies was able to reproduce true white-eyed offspring. The most elegant and convincing support for Darwin's ideas, however, was provided by the Luria-Delbruck experiment, which showed that mutations conferring resistance of the bacterium E. coli to T1 bacteriophage (virus) existed in the population prior to exposure to T1 and were not induced by adding T1. In other words, mutations are random events that occur whether or not they prove to be useful, while selection (for T1 resistance upon challenge with T1 in this case) provides the direction in evolution by retaining those mutations that are advantageous, discarding those that are harmful (T1 sensitivity in this case). This experiment dealt a blow to Lamarckian inheritance and set the stage for tremendous advances in genetics and molecular biology, launching a tsunami of research that eventually led to the discovery of DNA as the hereditary material and to cracking the genetic code. Of course, by then Avery, along with McCloud (and earlier, McCarty) was well on the way to showing the genetic capability of DNA.
731:, shared with Luria and Hershey "for their discoveries concerning the replication mechanism and the genetic structure of viruses". The committee also noted that "The honour in the first place goes to Delbrück who transformed bacteriophage research from vague empiricism to an exact science. He analyzed and defined the conditions for precise measurement of the biological effects. Together with Luria he elaborated the quantitative methods and established the statistical criteria for evaluation which made the subsequent penetrating studies possible. Delbrück's and Luria's forte is perhaps mainly theoretical analysis, whereas Hershey above all is an eminently skillful experimenter. The three of them supplement each other well also in these respects." That year, Delbrück and 518: 1741: 648: 58: 391: 461:. Justus died in Soviet custody that same year. His son, Tobias Delbruck is a professor at the Institute of Neuroinformatics at the University of Zurich and ETH Zurich. Professor Tobias Delbruck is also one of the pioneers in the domain of event cameras, now increasingly being deployed in dynamic vision systems. 703:
began visiting in 1943. The Luria–Delbrück experiment, also called the Fluctuation Test, demonstrated that Darwin's theory of natural selection acting on random mutations applies to bacteria as well as to more complex organisms. The 1969 Nobel Prize in Physiology or Medicine was awarded to both
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Luria SE "Mutations of bacteria and bacteriophage" in Phage and the Origins of Molecular Biology (2007) Edited by John Cairns, Gunther S. Stent, and James D. Watson, Cold Spring Harbor Laboratory of Quantitative Biology, Cold Spring Harbor, Long Island, New York, pgs. 173-179.
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Ellis E.L. "Bacteriophage: One-step growth curve" in Phage and the Origins of Molecular Biology (2007) Edited by John Cairns, Gunther S. Stent, and James D. Watson, Cold Spring Harbor Laboratory of Quantitative Biology, Cold Spring Harbor, Long Island, New York
1759:– Delbrück was instrumental in getting fellowship support for Watson so that he could stay in Cambridge, play tennis, and discover the rules of nucleotide base pairing in DNA. This is a letter from Watson to Delbrück that describes the discovery. 889:
A refugee from Nazi Germany, Delbrück went to the United States in 1937, serving as a faculty member of the California Institute of Technology (1937–39; 1947–81) and of Vanderbilt University (1940–47). He became a U.S. citizen in
776: 576:. It was considered to be a major advance in understanding the nature of gene mutation and gene structure. The work was a keystone in the formation of molecular genetics. It was also an inspirational starting point for 323: 3634: 1814: 832:. On August 26 to 27, 2006—the year Delbrück would have turned 100—family and friends gathered at Cold Spring Harbor Laboratory to reminisce on his life and work. Although Delbrück held some anti- 3669: 743:. In late 1947, as Vanderbilt lacked the resources to keep him, Delbrück had returned to Caltech as a professor of biology, and remained there for the rest of his career. Meanwhile, he set up 3644: 1666: 1245: 1489: 760: 3624: 1807: 3674: 3664: 3357: 954:
Ton van Helvoort (1992). "The controversy between John H. Northrop and Max Delbrück on the formation of bacteriophage: Bacterial synthesis or autonomous multiplication?".
1823: 1768: 1800: 3629: 1267: 821:, remaining a Professor of Biology emeritus. He became interested in the behavioral sciences and spent some unfruitful effort on mold behavior in the 1960s. 378:"for their discoveries concerning the replication mechanism and the genetic structure of viruses". He was the first physicist to predict what is now called 3315: 3304: 3289: 3270: 3689: 902: 3498: 1756: 1324: 1538: 1184: 1434: 3699: 3694: 3350: 933: 3467: 1827: 1464: 1410: 1322:
Max Delbrück and the Next 100 Years of Biology: The Max Delbrück Vanderbilt Centenary Celebration, The Inaugural Vanderbilt Discovery Lecture
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Luria SE. A Slot Machine, a Broken Test Tube. An Autobiography. Harper and Row, New York, 1984. Alfred P. Sloan Foundation Series
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Luria SE, Delbrück M. Mutations of bacteria from virus sensitivity to virus resistance. Genetics. 1943 Nov;28(6):491-511.
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Strauss BS. A Physicist's Quest in Biology: Max Delbrück and "Complementarity". Genetics. 2017 Jun;206(2):641-650.
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Timofeeff-Ressovky, N. W., K. G. Zimmer, and M. Delbrück "Über die Natur der Genmutation und der Genstruktur" (
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in their 1953 identification of cellular DNA's molecular structure as a double helix. In 1977, he retired from
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field's polarization of a vacuum. Though theoretically tenable, his conclusion was misplaced, whereas
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Lily E. Kay (1985). "Conceptual models and analytical tools: The biology of physicist Max Delbrück".
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Drawing of a plaque in Buttrick Hall, Vanderbilt University commemorating the work of Max Delbrück.
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Ellis E. L., Delbrück M. The growth of bacteriophage. J Gen Physiol. 1939 Jan 20;22(3):365-84.
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Oral History Project, California Institute of Technology Archives, Pasadena, California.
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Delbrück's workplace in Berlin: Kaiser Wilhelm Institute for Chemistry, now the
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Thinking about science : Max Delbrück and the origins of molecular biology
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thinking, a course of lectures in 1943, and the eventual writing of the book
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Daniel J. McKaughan (2005). "The Influence of Niels Bohr on Max Delbrück".
1010: 975: 671:, yet had his laboratory in the biology department. In 1941, Delbrück met 632:, he coauthored "The growth of bacteriophage", a paper reporting that the 1735: 824:
Max Delbrück died, at age 74, on the evening of Monday, March 9, 1981, at
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What Is Life? the Next Fifty Years: Speculations on the Future of Biology
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views; he conjectured that ultimately a paradox—akin perhaps to the
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in 1945. In 1941, he married Mary Bruce. They had four children.
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The Eighth Day of Creation: Makers of the Revolution in Biology
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fellowship expired in 1939, the Foundation matched him up with
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some 20 years later confirmed the phenomenon and named it "
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Delbrück's brother Justus, a lawyer, as well as his sister
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Linus Pauling and the Race for DNA: A Documentary History
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In 1945, Delbrück, Luria, and Hershey set up a course in
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made substantial headway unraveling important aspects of
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Biographical Memoirs of the National Academy of Sciences
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In addition to the Nobel Prize, Delbrück was elected a
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Delbrück returned to Berlin in 1932 as an assistant to
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Members of the European Molecular Biology Organization
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Foreign Member of the Royal Society (ForMemRS) in 1967
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Fellows of the American Academy of Arts and Sciences
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Biographical Memoirs of Fellows of the Royal Society
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What Is Life? The Physical Aspect of the Living Cell
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What Is Life? The Physical Aspect of the Living Cell
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O'Neill (1997). 1246:"MDC celebrates centennial of Max Delbrück" 437:were active along with his brothers-in-law 328:; September 4, 1906 – March 9, 1981) was a 3625:California Institute of Technology faculty 3358: 3344: 3336: 1815: 1801: 1793: 1739: 56: 38: 3675:Members of the French Academy of Sciences 3665:Nobel laureates in Physiology or Medicine 1716: 1577: 1506: 679:who began visiting Vanderbilt. In 1942, 455:July 20, 1944 plot to assassinate Hitler 1643:. Cold Spring Harbor Laboratory Press. 1539:European Molecular Biology Organization 1354:"Max Delbrück at Vanderbilt, 1940–1947" 926: 924: 857: 587:In 1937, he attained a fellowship from 1769:Caltech Photo Archives of Max Delbrück 879:from the original on December 26, 2018 255:Kaiser Wilhelm Institute for Chemistry 1828:Nobel Prize in Physiology or Medicine 1432:"James D Watson: Chancellor emeritus" 1158:from the original on October 15, 2012 729:Nobel Prize in Physiology or Medicine 376:Nobel Prize in Physiology or Medicine 315: 224:Nobel Prize in Physiology or Medicine 7: 3630:Foreign members of the Royal Society 667:, where from 1940 to 1947 he taught 1594:from the original on April 28, 2012 1236:(Cambridge University Press, 1944). 485:there in 1930, he traveled through 30:Not to be confused with his uncle, 1552:K. R. Dronamraju (November 1999). 1270:from the original on June 12, 2018 905:. Nobel Foundation. Archived from 701:Washington University in St. Louis 610:California Institute of Technology 406:. His mother was granddaughter of 342:in the late 1930s. He stimulated 335:who participated in launching the 25: 3439:International Labour Organization 991:Journal of the History of Biology 1441:, Cold Spring Harbor Laboratory. 875:. Encyclopædia Britannica, Inc. 3690:University of Göttingen alumni 1779:Key Participants: Max Delbrück 1616:. Cambridge University Press. 944:, Web access November 6, 2013. 1: 3700:American molecular biologists 3695:Vanderbilt University faculty 1751:Cold Spring Harbor Laboratory 1709:10.1016/S0006-3495(94)80873-2 1260:"Max Delbrück – Biographical" 1076:https://www.ini.uzh.ch/~tobi/ 846:double helix structure of DNA 775:and named in his honour. The 713:Cold Spring Harbor Laboratory 691:infection mediated by random 533:, who was collaborating with 826:Huntington Memorial Hospital 681:Delbrück and Luria published 374:. The three shared the 1969 3655:German molecular biologists 2920:Christiane Nüsslein-Volhard 1763:Interview with Max Delbrück 1669:September 23, 2015, at the 1570:10.1093/genetics/153.3.1071 1531:"Max Delbrück EMBO profile" 1206:10.1534/genetics.117.201517 394:Delbrück in the early 1940s 309:Max Ludwig Henning Delbrück 69:Max Ludwig Henning Delbrück 18:Max Ludwig Henning Delbruck 3716: 1437:December 11, 2013, at the 1327:November 19, 2012, at the 741:Louisa Gross Horwitz Prize 640:, not exponentially as do 566:Nikolay Timofeev-Ressovsky 218:Louisa Gross Horwitz Prize 34:, an agricultural chemist. 29: 3522: 2117:Charles Scott Sherrington 2093:Frederick Gowland Hopkins 1378:10.1093/genetics/28.6.491 1359:October 11, 2012, at the 1331:, Held September 14, 2006 1178:Weidmannsche Buchhandlung 1116:January 27, 2019, at the 1081:January 10, 2023, at the 968:10.1080/00033799200200451 773:American Physical Society 591:—which was launching the 523:Free University of Berlin 302: 233: 154:Luria–Delbrück experiment 55: 3620:American Nobel laureates 3107:Françoise Barré-Sinoussi 1122:Encyclopaedia Britannica 505:, who interested him in 1683:N. H. Horowitz (1994). 940:, Nobel Media AB 2013, 873:Encyclopædia Britannica 605:Drosophila melanogaster 481:. After completing his 479:University of Göttingen 386:Early and personal life 317:[maksˈdɛl.bʁʏk] 130:University of Göttingen 3680:Scientists from Berlin 3650:German Nobel laureates 3615:American biophysicists 3528:Nobel Prize recipients 3468:Physiology or Medicine 1888:Santiago Ramón y Cajal 1757:Letter from Jim Watson 1637:Horace Freeland Judson 1508:10.1098/rsbm.1982.0003 1187:March 3, 2022, at the 936:June 27, 2018, at the 657:Rockefeller Foundation 652: 616:, Delbrück researched 589:Rockefeller Foundation 526: 449:. Found guilty by the 395: 354:to physically explain 159:Saffman–Delbrück model 32:Max Delbrück (chemist) 2389:Dickinson W. Richards 2073:Julius Wagner-Jauregg 1182:Nachrichten Göttingen 791:Delbrück helped spur 787:Later life and legacy 783:also bears his name. 781:Helmholtz Association 745:University of Cologne 735:were also awarded by 717:Long Island, New York 661:Vanderbilt University 650: 520: 398:Delbrück was born in 393: 259:Vanderbilt University 3640:German biophysicists 2812:Rita Levi-Montalcini 2173:Albert Szent-Györgyi 1459:. New York: Norton. 1430:J.D. Watson (2012). 1264:Biographical article 838:waveparticle duality 830:Pasadena, California 763:. He was elected an 665:Nashville, Tennessee 655:Although Delbrück's 447:resistance to Nazism 424:University of Berlin 297:Charles M. Steinberg 105:Pasadena, California 3660:History of genetics 3204:William C. Campbell 3115:Elizabeth Blackburn 2952:Robert F. Furchgott 2944:Stanley B. Prusiner 2936:Rolf M. Zinkernagel 2836:George H. Hitchings 2800:Joseph L. Goldstein 2760:Bengt I. Samuelsson 2589:Earl Sutherland Jr. 1701:1994BpJ....66..929H 1695:(3 Pt 1): 929–930. 1689:Biophysical Journal 793:physical scientists 777:Max Delbrück Center 737:Columbia University 620:and their viruses ( 578:Erwin Schrödinger's 559:Delbrück scattering 513:Career and research 475:theoretical physics 473:, shifting towards 443:Dietrich Bonhoeffer 414:, while his father 380:Delbrück scattering 350:, especially as to 344:physical scientists 293:Ernst Peter Fischer 149:Delbrück scattering 3264:William Kaelin Jr. 3260:Peter J. Ratcliffe 3003:Leland H. Hartwell 2892:Richard J. Roberts 2772:Barbara McClintock 2716:Godfrey Hounsfield 2617:Nikolaas Tinbergen 2549:Marshall Nirenberg 2517:Charles B. Huggins 2306:Tadeusz Reichstein 2294:António Egas Moniz 2089:Christiaan Eijkman 1738:on Nobelprize.org 1232:Erwin Schrödinger 1003:10.1007/BF00120110 769:Max Delbruck Prize 755:Awards and honours 749:molecular genetics 677:Indiana University 653: 602:of the fruit fly, 549:' scattering by a 537:on irradiation of 527: 396: 3592: 3591: 3499:Economic Sciences 3333: 3332: 3298:Ardem Patapoutian 3147:Ralph M. Steinman 3143:Jules A. Hoffmann 3131:Robert G. Edwards 3099:Harald zur Hausen 3023:H. Robert Horvitz 2924:Eric F. Wieschaus 2860:E. Donnall Thomas 2844:J. Michael Bishop 2832:Gertrude B. Elion 2704:Hamilton O. Smith 2629:Christian de Duve 2365:Frederick Robbins 2242:Alexander Fleming 2181:Corneille Heymans 2027:Frederick Banting 1932:Allvar Gullstrand 1663:Max Delbruck 100. 1660:Kiryn Haslinger. 1466:978-0-393-02508-8 1411:978-0-87969-800-3 1311:978-0-87969-800-3 1134:W. Hayes (1992). 956:Annals of Science 807:Rosalind Franklin 799:in his 1944 book 797:Erwin Schrödinger 747:'s institute for 725:molecular biology 628:). In 1939, with 593:molecular biology 469:Delbrück studied 453:for roles in the 422:professor at the 408:Justus von Liebig 337:molecular biology 306: 305: 281:Doctoral students 235:Scientific career 145: 144:(Nobel Committee) 79:September 4, 1906 16:(Redirected from 3707: 3530: 3457:Murray Gell-Mann 3360: 3353: 3346: 3337: 3326: 3311: 3300: 3285: 3279:Michael Houghton 3266: 3256:Gregg L. Semenza 3250: 3244:James P. Allison 3238: 3236:Michael W. Young 3222: 3220:Yoshinori Ohsumi 3214: 3198: 3182: 3180:Thomas C. Südhof 3166: 3154: 3133: 3125: 3119:Carol W. Greider 3109: 3093: 3077: 3065: 3053: 3041: 3029: 3013: 2986: 2970: 2962: 2946: 2938: 2932:Peter C. Doherty 2926: 2910: 2904:Alfred G. Gilman 2898: 2886: 2874: 2862: 2850: 2848:Harold E. Varmus 2838: 2822: 2814: 2802: 2790: 2774: 2766: 2750: 2734: 2724:Baruj Benacerraf 2718: 2706: 2690: 2674: 2651: 2635: 2619: 2603: 2591: 2583: 2567: 2551: 2541:Robert W. Holley 2535: 2519: 2507: 2491: 2479: 2463: 2447: 2445:Georg von Békésy 2439: 2427: 2415: 2413:Joshua Lederberg 2399: 2391: 2385:Werner Forssmann 2375: 2367: 2351: 2339: 2331: 2312: 2296: 2284: 2276: 2274:Bernardo Houssay 2260: 2252: 2236: 2224: 2212: 2211: 2205: 2204: 2198: 2197: 2191: 2183: 2175: 2167: 2155: 2147: 2131: 2123: 2111: 2103: 2101:Karl Landsteiner 2095: 2083: 2075: 2067: 2065:Johannes Fibiger 2048: 2047: 2041: 2039:Willem Einthoven 2033: 2021: 2009: 2008: 2002: 1994: 1986: 1985: 1979: 1978: 1972: 1971: 1965: 1964: 1958: 1950: 1942: 1934: 1926: 1918: 1910: 1904:Élie Metchnikoff 1898: 1896:Alphonse Laveran 1890: 1878: 1870: 1862: 1854: 1846: 1817: 1810: 1803: 1794: 1743: 1723: 1722: 1720: 1680: 1674: 1658: 1652: 1634: 1628: 1610: 1604: 1603: 1601: 1599: 1581: 1549: 1543: 1542: 1527: 1521: 1520: 1510: 1477: 1471: 1470: 1458: 1448: 1442: 1428: 1422: 1419: 1413: 1402: 1396: 1370: 1364: 1351: 1332: 1319: 1313: 1302: 1296: 1286: 1280: 1279: 1277: 1275: 1258:Stefanie Tapke. 1255: 1249: 1243: 1237: 1230: 1224: 1198: 1192: 1174: 1168: 1167: 1165: 1163: 1131: 1125: 1107: 1101: 1092: 1086: 1072: 1066: 1065: 1029: 1023: 1022: 986: 980: 979: 951: 945: 928: 919: 918: 916: 914: 899: 893: 892: 886: 884: 865: 596:research program 572:the major work, 439:Klaus Bonhoeffer 346:' interest into 340:research program 327: 326: 325: 319: 314: 270:Doctoral advisor 143: 100: 78: 76: 60: 50: 39: 21: 3715: 3714: 3710: 3709: 3708: 3706: 3705: 3704: 3595: 3594: 3593: 3588: 3526: 3518: 3493: 3490:(United States) 3484:(United States) 3478:(United States) 3462: 3459:(United States) 3443: 3420: 3396: 3387:(Great Britain) 3371: 3364: 3334: 3329: 3314: 3303: 3288: 3283:Charles M. Rice 3275:Harvey J. Alter 3269: 3253: 3241: 3232:Michael Rosbash 3228:Jeffrey C. Hall 3225: 3217: 3201: 3192:May-Britt Moser 3185: 3169: 3164:Shinya Yamanaka 3157: 3136: 3128: 3123:Jack W. Szostak 3112: 3096: 3091:Oliver Smithies 3080: 3068: 3056: 3044: 3039:Peter Mansfield 3032: 3027:John E. Sulston 3016: 3000: 2989: 2973: 2965: 2949: 2941: 2929: 2916:Edward B. 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Index

Max Ludwig Henning Delbruck
Max Delbrück (chemist)
ForMemRS

Berlin
German Empire
Pasadena, California
United States
United States
University of Göttingen
Delbrück scattering
Luria–Delbrück experiment
Saffman–Delbrück model
Hans Delbrück
Emmi Bonhoeffer
Mendel Medal
Louisa Gross Horwitz Prize
Nobel Prize in Physiology or Medicine
Biophysics
Kaiser Wilhelm Institute for Chemistry
Vanderbilt University
Caltech
Doctoral advisor
Lise Meitner
Lily Jan
Yuh Nung Jan
Ernst Peter Fischer
Charles M. Steinberg
[maksˈdɛl.bʁʏk]

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