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complex on the surface of infected cells and destroy these cells. Specific CD8+ T cells are generated in secondary lymphoid organs where naïve T cells encounter with cytomegalovirus antigen on antigen presenting cells. This results in a population of migrating effector CD8 + T-lymphocytes and the
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Remodeling of immune response and reduced ability to protect individuals from infectious diseases is observed in relation to age. Especially in the elderly, long-term CMV infection leads to a rapid increase the number of CMV-specific T cells. The number of CMV memory CD8 + T lymphocytes then
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predominate and the total number of available naïve T lymphocytes decrease. CD8+T cells form up to 50 % of all peripheral blood memory cells in HCV-positive elderly individuals. The same effect on the immune system has been described in herpes viruses and parvoviruses.
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Welten, Suzanne P. M.; Sandu, Ioana; Baumann, Nicolas S.; Oxenius, Annette (2018). "Memory CD8 T cell inflation vs tissue-resident memory T cells: Same patrollers, same controllers?".
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which affects 60-80 % of the human population in developed countries. The virus is spread through saliva or urine and in healthy individuals can survive under the
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recognition. The amount of memory cells generated as a response to cytomegalovirus is approximately 9.1% - 10.2% of all circulating CD4 + and CD8 + memory cells.
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Generally, these cells express a low level of node localization markers - CD62L, CCR7 and occur in peripheral organs. They retain their standard functions like
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control without any visible symptoms. The CMV life strategy is to integrate DNA into the genome of the host cells and escape the mechanism of natural immunity.
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O'Hara, Geraldine A.; Welten, Suzanne P. M.; Klenerman, Paul; Arens, Ramon (February 2012). "Memory T cell inflation: understanding cause and effect".
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based on induction of memory T cells in the periphery that will be capable of effectively and immediately attacking the pathogen.
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Arens, Ramon; Klenerman, Paul; Welten, Suzanne P. M.; O’Hara, Geraldine A. (2012-02-01).
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against CMV is primarily provided by CD8 + T cells which recognize viral fragments in
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receptor inhibitors on the surface, but they express the inhibitory molecules
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Shin, Eui-Cheol; Kim, A.-Reum; Kim, Jihye (2015-08-01).
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Kim, Jihye; Kim, A-Reum; Shin, Eui-Cheol (August 2015).
305:"Cytomegalovirus Infection and Memory T Cell Inflation"
249:"Cytomegalovirus Infection and Memory T Cell Inflation"
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74:Memory T cell inflation
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604:Immunology
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501:1600-065X
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110:Infection
40:. Please
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