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the cell membrane. These particles are optically transparent, so the dye can be seen through the silica walls. The dye in the particles does not have the same problem with self-quenching that a dye in solution has. The types of molecules that are grafted to the outside of the MSNs will control what kinds of biomolecules are allowed inside the particles to interact with the dye.
222:
294:
The structure of these particles allows them to be filled with a fluorescent dye that would normally be unable to pass through cell walls. The MSN material is then capped off with a molecule that is compatible with the target cells. When the MSNs are added to a cell culture, they carry the dye across
280:
Ordered mesoporous silica (e.g. SBA-15, TUD-1, HMM-33, and FSM-16) also show potential to boost the in vitro and in vivo dissolution of poorly water-soluble drugs. Many drug-candidates coming from drug discovery suffer from a poor water solubility. An insufficient dissolution of these hydrophobic
1191:
Mellaerts, Randy; Houthoofd, Kristof; Elen, Ken; Chen, Hong; Van
Speybroeck, Michiel; Van Humbeeck, Jan; Augustijns, Patrick; Mullens, Jules; Van Den Mooter, Guy; Martens, Johan A. (2010). "Aging behavior of pharmaceutical formulations of itraconazole on SBA-15 ordered mesoporous silica carrier
182:
A compound producing mesoporous silica was patented around 1970. It went almost unnoticed and was reproduced in 1997. Mesoporous silica nanoparticles (MSNs) were independently synthesized in 1990 by researchers in Japan. They were later produced also at Mobil
Corporation laboratories and named
285:
which is an antimycoticum known for its poor aqueous solubility. Upon introduction of itraconazole-on-SBA-15 formulation in simulated gastrointestinal fluids, a supersaturated solution is obtained giving rise to enhanced transepithelial intestinal transport. Also the efficient uptake into the
1155:
Mellaerts, Randy; Mols, Raf; Jammaer, Jasper A.G.; Aerts, Caroline A.; Annaert, Pieter; Van
Humbeeck, Jan; Van Den Mooter, Guy; Augustijns, Patrick; Martens, Johan A. (2008). "Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica".
1119:
Mellaerts, Randy; Mols, Raf; Kayaert, Pieterjan; Annaert, Pieter; Van
Humbeeck, Jan; Van Den Mooter, Guy; Martens, Johan A.; Augustijns, Patrick (2008). "Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced
1219:
Van
Speybroeck, Michiel; Barillaro, Valéry; Thi, Thao Do; Mellaerts, Randy; Martens, Johan; Van Humbeeck, Jan; Vermant, Jan; Annaert, Pieter; et al. (2009). "Ordered mesoporous silica material SBA-15: A broad-spectrum formulation platform for poorly soluble drugs".
256:
However, TEOS is not the most effective precursor for synthesizing such particles; a better precursor is (3-Mercaptopropyl)trimethoxysilane, often abbreviated to MPTMS. Use of this precursor drastically reduces the chance of aggregation and ensures more uniform spheres.
277:, depending on what chemicals are attached to the outside of the spheres. Some types of cancer cells will take up more of the particles than healthy cells will, giving researchers hope that MCM-41 will one day be used to treat certain types of cancer.
286:
systemic circulation of SBA-15 formulated itraconazole has been demonstrated in vivo (rabbits and dogs). This approach based on SBA-15 yields stable formulations and can be used for a wide variety of poorly water-soluble compounds.
241:
with a template made of micellar rods. The result is a collection of nano-sized spheres or rods that are filled with a regular arrangement of pores. The template can then be removed by washing with a solvent adjusted to the proper
716:
Valenti G, Rampazzo R, Bonacchi S, Petrizza L, Marcaccio M, Montalti M, Prodi L, Paolucci F (2016). "Variable Doping
Induces Mechanism Swapping in Electrogenerated Chemiluminescence of Ru(bpy)32+ Core−Shell Silica Nanoparticles".
602:
Beck, J. S.; Vartuli, J. C.; Roth, W. J.; Leonowicz, M. E.; Kresge, C. T.; Schmitt, K. D.; Chu, C. T. W.; Olson, D. H.; Sheppard, E. W. (1992). "A New Family of
Mesoporous Molecular Sieves Prepared with Liquid Crystal Templates".
762:
Mitran, Raul−Augustin; Berger, Daniela; Munteanu, Cornel; Matei, Cristian (2015). "Evaluation of
Different Mesoporous Silica Supports for Energy Storage in Shape-Stabilized Phase Change Materials with Dual Thermal Responses".
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Radu, Daniela R; Lai, Chen-Yu; Jeftinija, Ksenija; Rowe, Eric W; Jeftinija, Srdija & Lin, Victor S.-Y. (2004). "A Polyamidoamine
Dendrimer-Capped Mesoporous Silica Nanosphere-Based Gene Transfection Reagent".
1011:
Mellaerts, Randy; Aerts, Caroline A.; Humbeeck, Jan Van; Augustijns, Patrick; Den Mooter, Guy Van; Martens, Johan A. (2007). "Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials".
408:
Trewyn, Brian G; Nieweg, Jennifer A; Zhao, Yannan; Lin, Victor S.-Y. (2007). "Biocompatible mesoporous silica nanoparticles with different morphologies for animal cell membrane penetration".
333:
Nandiyanto, Asep Bayu Dani; Kim, Soon-Gil; Iskandar, Ferry; Okuyama, Kikuo (2009). "Synthesis of Silica
Nanoparticles with Nanometer-Size Controllable Mesopores and Outer Diameters".
360:
Katiyar, Amit; Yadav, Santosh; Smirniotis, Panagiotis G.; Pinto, Neville G. (July 2006). "Synthesis of ordered large pore SBA-15 spherical particles for adsorption of biomolecules".
1255:
Trewyn, Brian G; Supratim, Giri; Slowing, Igor I; Lin, Victor S.-Y. (2007). "Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems".
837:
Nandiyanto, A. B. D.; Iskandar, F. & Okuyama, K. (2008). "Nano-sized Polymer Particle-Facilitated Preparation of Mesoporous Silica Particles Using a Spray Method".
1043:
Heikkila, T; Salonen, J; Tuura, J; Hamdy, M; Mul, G; Kumar, N; Salmi, T; Murzin, D; et al. (2007). "Mesoporous silica material TUD-1 as a drug delivery system".
155:'s terminology, mesoporosity sits between microporous (<2 nm) and macroporous (>50 nm). Mesoporous silica is a relatively recent development in
191:
790:
Ghajeri, Farnaz; Topalian, Zareh; Tasca, Andrea; Jafri, Syed Hassan Mujtaba; Leifer, Klaus; Norberg, Peter; Sjöström, Christer (2018-08-01).
526:
454:
673:; Chmelka, Bradley F.; Stucky, Galen D. (1998). "Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores".
956:"Surface PEGylation of Mesoporous Silica Nanorods (MSNR): Effect on loading, release, and delivery of mitoxantrone in hypoxic cancer cells"
632:"Synthesis and Functionalization of a Mesoporous Silica Nanoparticle Based on the Sol–Gel Process and Applications in Controlled Release"
108:
46:
39:
125:
954:
Wani, Amit; Savithra, Galbokka H. Layan; Abyad, Ayat; Kanvinde, Shrey; Li, Jing; Brock, Stephanie; Oupický, David (2017-05-23).
89:
61:
866:"Effect of 3-mercaptopropyltrimethoxysilane on Surface Finish and Material Removal Rate in Chemical Mechanical Polishing"
68:
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129:
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253:, or a spray drying method. Tetraethyl orthosilicate is also used with an additional polymer monomer (as a template).
184:
1078:
Tozuka, Yuichi; Wongmekiat, Arpansiree; Kimura, Kyoko; Moribe, Kunikazu; Yamamura, Shigeo; Yamamoto, Keiji (2005).
195:
164:
75:
35:
1327:
238:
57:
542:
Direnzo, F; Cambon, H; Dutartre, R (1997). "A 28-year-old synthesis of micelle-templated mesoporous silica".
899:"The Practicality of Mesoporous Silica Nanoparticles as Drug Delivery Devices and Progress Toward This Goal"
571:"The preparation of alkyltrimethylammonium-kanemite complexes and their conversion to microporous materials"
791:
670:
481:
Application No. US 3556725D A filed on 26-Feb-1969; Publication No. US 3556725 A published on 19-Jan-1971
505:; Application No. US 342525 A filed on 04-Feb-1964; Publication No. US 3383172 A published on 14-May-1968
493:
Application No. US 3493341D A filed on 23-Jan-1967; Publication No. US 3493341 A published on 03-Feb-1970
190:
Six years later, silica nanoparticles with much larger (4.6 to 30 nanometer) pores were produced at the
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structure, that is, having pores that range from 2 nm to 50 nm in diameter. According to
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drugs in the gastrointestinal fluids strongly limits the oral bioavailability. One example is
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792:"Case study of a green nanoporous material from synthesis to commercialisation: Quartzene®"
229:
1080:"Effect of Pore Size of FSM-16 on the Entrapment of Flurbiprofen in Mesoporous Structures"
179:. Mesoporous ordered silica films have been also obtained with different pore topologies.
176:
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The large surface area of the pores allows the particles to be filled with a drug or a
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Mesoporous particles can also be synthesized using a simple sol-gel method such as the
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Roggers, Robert; Kanvinde, Shrey; Boonsith, Suthida; Oupický, David (2014-10-01).
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Sivanandini, M.; Dhami, Sukhdeep S.; Pabla, B.S.; Gupta, M.K. (January 2014).
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The researchers who invented these types of particles planned to use them as
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Yanagisawa, Tsuneo; Shimizu, Toshio; Kuroda, Kazuyuki; Kato, Chuzo (1990).
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Chemistry of zeolites and related porous materials: synthesis and structure
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Trewyn, B. G.; Slowing, I. I.; Giri, S; Chen, H. T.; Lin, V. S. (2007).
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273:, the particles will be taken up by certain biological cells through
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491:"Porous silica particles containing a crystallized phase and method"
441:. Advances in Sol-Gel Derived Materials and Technologies. Springer.
205:. Today, mesoporous silica nanoparticles have many applications in
194:. The material was named Santa Barbara Amorphous type material, or
228:
220:
167:. Research continues on the particles, which have applications in
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Zhao, Dongyuan; Feng, Jianglin; Huo, Qisheng; Melosh, Nicholas;
18:
213:, thermal energy storage, water/gas filtration and imaging.
503:"Process for producing silica in the form of hollow spheres"
438:
Mesoporous ordered silica films. From self-assembly to order
237:
Mesoporous silica nanoparticles are synthesized by reacting
243:
198:. These particles also have a hexagonal array of pores.
159:. The most common types of mesoporous nanoparticles are
1158:
European Journal of Pharmaceutics and Biopharmaceutics
796:Current Opinion in Green and Sustainable Chemistry
479:"Process for producing low-bulk density silica."
477:Chiola, V.; Ritsko, J. E. and Vanderpool, C. D.
233:TEM image of a mesoporous silica nanoparticle
8:
515:Xu, Ruren; Pang, Wenqin; Yu, Jihong (2007).
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575:Bulletin of the Chemical Society of Japan
109:Learn how and when to remove this message
1289:Journal of the American Chemical Society
605:Journal of the American Chemical Society
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192:University of California, Santa Barbara
187:(or Mobil Crystalline Materials, MCM).
1122:International Journal of Pharmaceutics
1084:Chemical & Pharmaceutical Bulletin
1045:International Journal of Pharmaceutics
45:Please improve this article by adding
7:
1194:Microporous and Mesoporous Materials
335:Microporous and Mesoporous Materials
765:The Journal of Physical Chemistry C
521:. Wiley-Interscience. p. 472.
1222:Journal of Pharmaceutical Sciences
132:(SEM) images of mesoporous silica
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16:Nano-scale porous silica compound
126:Transmission electron microscopy
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1057:10.1016/j.ijpharm.2006.09.019
636:Accounts of Chemical Research
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147:that is characterised by its
47:secondary or tertiary sources
1120:transepithelial transport".
695:10.1126/science.279.5350.548
410:Chemical Engineering Journal
374:10.1016/j.chroma.2006.04.055
130:scanning electron microscopy
883:10.1016/j.mspro.2014.07.067
808:10.1016/j.cogsc.2018.07.003
362:Journal of Chromatography A
185:Mobil Composition of Matter
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1170:10.1016/j.ejpb.2007.11.006
972:10.1038/s41598-017-02531-4
870:Procedia Materials Science
435:Innocenzi, Plinio (2022).
225:Vials of mesoporous silica
915:10.1208/s12249-014-0142-7
447:10.1007/978-3-030-89536-5
422:10.1016/j.cej.2007.09.045
777:10.1021/acs.jpcc.5b02608
239:tetraethyl orthosilicate
1257:Chemical Communications
1014:Chemical Communications
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544:Microporous Materials
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310:Mesoporous silicates
1333:Mesoporous material
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305:Mesoporous material
58:"Mesoporous silica"
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839:Chemistry Letters
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966:(1): 2274.
876:: 528–537.
802:: 101–109.
275:endocytosis
1322:Categories
316:References
290:Biosensors
211:biosensors
149:mesoporous
99:March 2020
69:newspapers
36:references
980:2045-2322
923:1530-9932
824:139146490
816:2452-2236
465:245147740
382:0021-9673
269:. Like a
267:cytotoxin
217:Synthesis
169:catalysis
1309:15479063
1273:17668088
1242:19072861
1178:18164930
1142:18325700
1106:16079530
1065:17046183
1030:17377687
998:28536462
941:24871552
749:27960352
656:17645305
390:16716334
299:See also
207:medicine
989:5442097
932:4179667
703:9438845
683:Bibcode
675:Science
177:imaging
83:scholar
1307:
1271:
1240:
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165:SBA-15
161:MCM-41
145:silica
85:
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820:S2CID
461:S2CID
153:IUPAC
90:JSTOR
76:books
1305:PMID
1269:PMID
1238:PMID
1174:PMID
1138:PMID
1102:PMID
1061:PMID
1026:PMID
994:PMID
976:ISSN
937:PMID
919:ISSN
812:ISSN
745:PMID
699:PMID
652:PMID
523:ISBN
451:ISBN
386:PMID
378:ISSN
366:1122
175:and
163:and
62:news
1297:doi
1293:126
1261:doi
1230:doi
1202:doi
1198:130
1166:doi
1130:doi
1126:357
1092:doi
1053:doi
1049:331
1018:doi
984:PMC
968:doi
927:PMC
911:doi
878:doi
847:doi
804:doi
773:doi
769:119
735:hdl
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691:doi
679:279
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