25:
462:
through a whistleblower. By 26 March 2021, Coulthart as CJDSS director, had ruled out "a prion disease such as
Creutzfeldt-Jakob disease (CJD)" even though there were many similarities. At that time, early on in their research, a "top priority" was to investigate possible exposure to toxins.
828:
Booth, Stephanie; Bowman, Christopher; Baumgartner, Richard; Dolenko, Brion; Sorensen, Garrett; Robertson, Catherine; Coulthart, Michael; Phillipson, Clark; Somorjai, Rajmund (December 2004). "Molecular classification of scrapie strains in mice using gene expression profiling".
428:
In June 2019, Coulthart was the lead interviewee who was called to answer the question: "Why did deer meat from an infected herd end up in Canada's food chain?" when "scientists, indigenous leaders and wildlife advocates signed a letter to Prime
Minister
674:
Kwok, Anita Y. C.; Wilson, Jason T.; Coulthart, Michael; Ng, Lai-King; Mutharia, Lucy; Chow, Anthony W. (10 February 2011). "Phylogenetic study and identification of human pathogenic Vibrio species based on partial hsp60 gene sequences".
751:
Coulthart, Michael B; Mogk, Rhonda; Rancourt, Jason M; Godal, Deborah L; Czub, Stefanie (1 December 2003). "Prion protein gene sequence of Canada's first non-imported case of bovine spongiform encephalopathy (BSE)".
630:
Abed, Yacine; Coulthart, Michael B.; Li, Yan; Boivin, Guy (2003). "Evolution of
Surface and Nonstructural-1 Genes of Influenza B Viruses Isolated in the Province of Québec, Canada, during the 1998–2001 Period".
594:
Hardy, Isabelle; Li, Yan; Coulthart, Michael B; Goyette, Nathalie; Boivin, Guy (August 2001). "Molecular evolution of influenza A/H3N2 viruses in the province of Québec (Canada) during the 1997–2000 period".
1108:
D’Arcy, Colleen E; Bitnun, Ari; Coulthart, Michael B; D’Amour, Rolande; Friedman, Jeremy; Knox, J David; Rapoport, Adam; Carter, Snead; Widjaja, Elysa; Hazrati, Lili-Naz; Jansen, Gerard H (1 April 2019).
357:
In 2019, Coulthart was concerned with a girl from
Ontario who died of sCJD "with initially rapid neurocognitive decline followed by a prolonged (~10 years) clinical course. Neuropathological findings at
905:
Li, Li; Coulthart, Michael B.; Balachandran, Aru; Chakrabartty, Avi; Cashman, Neil R. (December 2007). "Species barriers for chronic wasting disease by in vitro conversion of prion protein".
787:
Booth, Stephanie; Bowman, Christopher; Baumgartner, Richard; Sorensen, Garrett; Robertson, Catherine; Coulthart, Michael; Phillipson, Clark; Somorjai, Rajmund L. (1 November 2004).
449:
1180:
140:
168:
1051:"Exploring Physical and Chemical Factors Influencing the Properties of Recombinant Prion Protein and the Real-Time Quaking-Induced Conversion (RT-QuIC) Assay"
42:
33:
1195:
940:
Coulthart, Michael B; Jansen, Gerard H; Olsen, Elina; Godal, Deborah L; Connolly, Tim; Choi, Bernard CK; Wang, Zheng; Cashman, Neil R (December 2011).
442:
164:
1224:
1151:
156:
789:"Identification of central nervous system genes involved in the host response to the scrapie agent during preclinical and clinical infection"
864:
Robertson, Catherine; Booth, Stephanie A.; Beniac, Daniel R.; Coulthart, Michael B.; Booth, Timothy F.; McNicol, Archibald (15 May 2006).
942:"Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study"
1234:
325:
1219:
119:
49:
405:. With its longer disease duration and atypical manifestations of white matter loss, CJD-LS can be clinically mistaken for other
257:
245:
241:
to write a paper on "Variant
Creutzfeldt-Jakob disease: A summary of current scientific knowledge in relation to public health".
551:
Coulthart, Michael B.; Rhomberg, Lorenz R.; Singh, Rama S. (May 1984). "The Nature of
Genetic Variation for Species Formation".
100:
72:
231:
144:
1181:"The Public Health Agency of Canada is working with the province to find the source of a deadly neurological disease in NB"
1049:
Cheng, Keding; Sloan, Angela; Avery, Kristen M.; Coulthart, Michael; Carpenter, Michael; Knox, J. David (3 January 2014).
445:(who are an intimately concerned party because they eat the meat from the deer which they kill) about the problem of CWD.
79:
260:(BSE) in an animal not known to be imported from a country with cattle previously affected by this fatal, transmissible
502:
Doherty, JA (1 October 2006). "Final report and recommendations from the
National Notifiable Diseases Working Group".
437:." Amongst the signatories of this letter was Coulthart's colleague Cashman. The catalyst was the plague of CWD that
406:
86:
38:
68:
1199:
438:
290:
172:
712:"Variant Creutzfeldt-Jakob disease: A summary of current scientific knowledge in relation to public health"
347:
1229:
529:
398:
279:
219:
1166:"Dr. Michael Coulthart speaks about the potential connections between #cwd 🦌 and human health #fightcwd"
227:
223:
204:
433:
urging immediate action to stop the spread" of CWD in Canada, and "to recognize the dire nature of this
317:
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should be carefully considered, even in younger patients with slower disease progression."
453:
1066:
275:. At the time he worked in the Division of Host Genetics and Prion Diseases of the NML.
1085:
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350:
and (CSF)," and "has great potential to become a method for diagnosing prion disease
252:, where he reported that "In May 2003, Canada became the 22nd country outside of the
1035:
580:
660:
480:
458:
378:
1111:"Sporadic Creutzfeldt-Jakob Disease in a Young Girl With Unusually Long Survival"
1075:
421:
conditions. This case clearly demonstrates that with rapid-onset encephalopathy,
1196:"Researcher says brain disorder in N.B. may be linked to environmental exposure"
382:
374:
351:
52:. Contentious material about living persons that is unsourced or poorly sourced
24:
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616:
572:
515:
1127:
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788:
866:"Cellular prion protein is released on exosomes from activated platelets"
452:(NSUC) cluster, which was first identified in 2019. The existence of the
434:
418:
390:
363:
313:
249:
176:
148:
1152:"Why did deer meat from an infected herd end up in Canada's food chain?"
370:
359:
343:
339:
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1008:
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was published in a provincial government memo which was leaked to the
331:
In 2013, Coulthart
Cashman et al described at an academic conference
211:
1168:. Ontario Federation of Anglers and Hunters. Twitter. 15 March 2019.
765:
688:
342:
assay, which is "able to detect low levels of the disease-inducing
448:
Coulthart was the federal lead on the 2021 investigation into the
302:
261:
215:
163:. It is unknown whether PHAC tracks in an official capacity other
439:
was discovered on or around certain deer farms in southern Quebec
155:
disease. In 2006, a working group named "classic CJD" as well as
294:
272:
1183:. CBC Listen. Information Morning - Moncton with Jonna Brewer.
298:
18:
441:. Coulthart had on 15 March 2019 made a presentation to the
385:
involvement, minimal spongiform change, PrP deposits in the
992:"Prion and Prion-like Diseases in Humans: Poster Abstracts"
203:
around the turn of the millennium while he was researching
167:(TSE), but Coulthart is on the Advisory Committee of the
308:
In 2011, Coulthart, Cashman et al studied "the value of
267:
In
November 2004, Coulthart was co-author of a study on
1115:
450:
New Brunswick neurological syndrome of unknown cause
1198:. Verizon Media. The Canadian Press. Archived from
907:
Biochemical and Biophysical Research Communications
831:
Biochemical and Biophysical Research Communications
244:As early as December 2003, Coulthart worked at the
532:Center for Infectious Disease Research and Policy
169:Center for Infectious Disease Research and Policy
289:In 2007, Coulthart participated in research on
278:In 2006, Coulthart participated in research on
199:. He appears to have been affiliated with the
333:Creutzfeldt-Jakob disease reporting in Canada
141:Creutzfeldt–Jakob Disease Surveillance System
8:
139:who is employed as the head of the Canadian
324:patients with relatively low prevalence of
207:. In 2002, he co-authored a study on human
187:Little is known of Coulthart's early life.
1126:
1084:
1074:
1017:
1007:
967:
957:
881:
804:
727:
710:Coulthart, M. B.; Cashman, N. R. (2001).
443:Ontario Federation of Anglers and Hunters
165:transmissible spongiform encephalopathies
120:Learn how and when to remove this message
472:
230:) on which the first author was at the
338:In 2014, Coulthart et al studied the
320:in a clinical population of subacute
7:
716:Canadian Medical Association Journal
305:, along with collaborator Cashman.
565:10.1111/j.1558-5646.1984.tb00336.x
504:Canada Communicable Disease Report
326:sporadic Creutzfeldt-Jakob disease
237:In 2001, Coulthart teamed up with
14:
346:of the prion protein (PrP(d)) in
226:, usually associated with eating
157:Variant Creutzfeldt–Jakob disease
1194:Bissett, Kevin (26 March 2021).
677:Canadian Journal of Microbiology
258:bovine spongiform encephalopathy
246:National Microbiology Laboratory
23:
1179:Brewer, Jonna (24 March 2021).
1225:Canadian public health doctors
232:University of British Columbia
145:Public Health Agency of Canada
1:
1150:Crowe, Kelly (22 June 2019).
609:10.1016/s0168-1702(01)00269-6
373:with relative sparing of the
195:In 1983, Coulthart worked at
50:secondary or tertiary sources
1076:10.1371/journal.pone.0084812
56:, especially if potentially
34:biography of a living person
793:Journal of General Virology
54:must be removed immediately
1251:
919:10.1016/j.bbrc.2007.10.087
883:10.1182/blood-2005-02-0802
843:10.1016/j.bbrc.2004.10.150
530:"Michael Coulthart, Ph.D."
407:neurodegenerative diseases
377:, cerebral and cerebellar
147:(PHAC), which terms CJD a
1235:Canadian health officials
1220:Canadian microbiologists
959:10.1186/1471-2377-11-133
645:10.1023/a:1025768308631
291:chronic wasting disease
173:Chronic Wasting Disease
16:Canadian microbiologist
399:protease-resistant PrP
293:, the term for TSE in
280:Cellular prion protein
220:Gram-negative bacteria
48:Please help by adding
1002:(sup1): 54–80. 2013.
806:10.1099/vir.0.80110-0
362:included generalized
348:brain tissue biopsies
395:immunohistochemistry
256:to report a case of
201:University of Quebec
1128:10.1093/jnen/nlz013
1067:2014PLoSO...984812C
481:"Michael Coulthart"
310:cerebrospinal fluid
228:undercooked seafood
224:foodborne infection
205:influenza B viruses
197:McMaster University
161:notifiable diseases
143:(CJDSS) within the
69:"Michael Coulthart"
37:relies too much on
403:Western immunoblot
393:and cerebellum by
318:diagnostic markers
1202:on 28 April 2021.
1009:10.4161/pri.24865
876:(10): 3907–3911.
799:(11): 3459–3471.
133:Michael Coulthart
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597:Virus Research
586:
559:(3): 689–692.
543:
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510:(19): 211–25.
494:
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431:Justin Trudeau
322:encephalopathy
254:United Kingdom
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137:microbiologist
135:is a Canadian
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600:
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524:
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485:. Retrieved
475:
459:Radio-Canada
457:
447:
427:
413:setting for
409:, or in the
379:white matter
356:
337:
332:
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243:
239:Neil Cashman
236:
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132:
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633:Virus Genes
483:. goc411.ca
383:gray matter
352:ante mortem
222:that cause
214:species (a
60:or harmful.
1214:Categories
952:(1): 133.
467:References
375:hippocampi
368:cerebellar
264:disease."
209:pathogenic
183:Early life
153:infectious
110:April 2021
80:newspapers
39:references
553:Evolution
415:metabolic
411:pediatric
387:neocortex
328:(sCJD)."
284:platelets
282:in human
248:(NML) in
1137:30856268
1095:24404191
1055:PLOS ONE
1036:42037283
1028:29095080
978:22032272
927:17964288
892:16434486
851:15555574
815:15483264
774:14663519
738:11468957
697:12489780
653:14501190
617:11451491
581:12537493
573:28555966
516:17076030
435:epidemic
391:striatum
364:cerebral
314:proteins
250:Winnipeg
177:cervidae
149:zoonotic
58:libelous
1086:3880330
1063:Bibcode
1019:4031668
969:3216246
661:6022963
536:3 April
487:3 April
419:genetic
371:atrophy
360:autopsy
344:isoform
340:RT-QuIC
269:scrapie
159:as two
94:scholar
1154:. CBC.
1135:
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397:, and
312:(CSF)
301:, and
212:Vibrio
191:Career
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1032:S2CID
996:Prion
870:Blood
729:81246
657:S2CID
577:S2CID
303:moose
262:prion
216:genus
101:JSTOR
87:books
32:This
1133:PMID
1091:PMID
1024:PMID
974:PMID
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888:PMID
847:PMID
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770:PMID
734:PMID
693:PMID
649:PMID
613:PMID
569:PMID
538:2021
512:PMID
489:2021
381:and
366:and
295:deer
273:mice
171:for
151:and
73:news
1123:doi
1081:PMC
1071:doi
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316:as
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91:·
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77:·
46:.
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