174:"This is important because one hypothesis for how an abnormal microbiome could contribute to metabolic disease and weight gain is by damaging the gut barrier that keeps toxins and pathogens from crossing into the bloodstream. When this occurs, it can set off a cascade of inflammation, contributing to insulin resistance, cardiovascular disease and autoimmune conditions, said Dr. Michael Silverman, the lead author of the study and the chairman of infectious diseases at Western University in Ontario”, the New York Times reported.
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pregnancy and only went to clinics during labour. In order to entice them to visit doctors during pregnancy, he instituted a program of ultrasounds with the promise that the women could see their unborn baby. This was a tremendous incentive and caused a jump in antenatal clinic visits by pregnant women.
193:
He demonstrated that the sharing of equipment used to inject drugs could help to spread HIV and
Hepatitis C. The reuse of the equipment could also help to lead to bacterial contamination and then endocarditis, an infection with a high mortality. He demonstrated that this was especially problematic
42:
to lead medical teams offering free medical treatment to the country's residents when their health system was not able to serve those in remote communities. For the first few years
Silverman's work was accomplished through Ve'ahavta, a Jewish humanitarian organization based out of Toronto. He was
88:
Silverman worked in Africa to treat mothers during pregnancy and their newborn babies noting that treatment for H.I.V., syphilis, malaria and high blood pressure, can make enormous differences in whether mother and baby survive the birth. Many
African women relied on traditional healers during
117:
infection. He demonstrated that the procedure could be both efficacious and made simple enough for patients to do on their own at home. He also studies ways to try to reduce the overuse of antibiotics in the community. This may help reduce the incidence of
194:
when long acting opiates were used. He initiated a novel community program to “cook your wash” and thus partially sterilize the fluid which would be injected using a cigarette lighter. This program helped to end an HIV outbreak in London, Ontario
170:
In a
Canadian study where Silverman served as principal investigator, the effects of fecal transplants on liver fat in people with fatty liver disease showed changes in the recipients’ guts, making the gut membrane less permeable, or “leaky.”
65:. According to the study, Columbus and his men would have carried the nonvenereal tropical bacteria home, where the organisms may have mutated into a more deadly form in the different conditions of Europe.
647:
Silverman, Michael; Slater; Jandoc; Garg; Weir (January 22, 2020). "Hydromorphone and the Risk of
Infective Endocarditis Among People Who Inject Drugs: A Population Based Retrospective Cohort Study".
92:
Silverman also led a study linking the rise of tuberculosis with food shortages in
Zimbabwe following the economic collapse. Locals were particularly susceptible to infectious diseases including HIV.
299:
Harper, Kristin N.; Ocampo, Paolo S.; Steiner, Bret M.; George, Robert W.; Silverman, Michael S.; Bolotin, Shelly; Pillay, Allan; Saunders, Nigel J.; Armelagos, George J. (15 January 2008).
143:
201:, was associated with a reduced risk of death, possibly because patients were more receptive to change when they realized the lethal potential of this highly fatal complication.
95:
The economic collapse also led to a decrease in HIV infections. Silverman pointed to the fact that sex workers could not ply their trade if people had no money to employ them.
605:
767:
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Silverman also showed that starting addiction counselling while in hospital (as opposed to after their release) for persons who inject drugs with heart valve
694:
502:"Extended Screening Costs Associated With Selecting Donors for Fecal Microbiota Transplantation for Treatment of Metabolic Syndrome-Associated Diseases"
50:
in some regions of Guyana was leading to widespread use of antimalarial drugs, which then caused bacteria to become resistant to important antibiotics (
762:
405:"Highly active anti-retroviral therapy in the prevention of mother-to-child transmission of HIV in rural Zimbabwe during the socio-economic crisis"
675:
248:
57:
Through his work in Guyana, Silverman was among the team that discovered the relationship between Yaws in the New World and the outbreak of
281:
403:
Thistle, Paul; Bolotin, Shelly; Lam, Eugene; Schwarz, Dan; Pilon, Richard; Ndawana, Billy; E Simor, Andrew; Silverman, Michael (2011).
370:
54:). Malarial control using bednets and other non-antibiotic means could then help prevent the loss of utility of these antibiotics.
26:
and infectious disease and Chief of
Infectious Diseases at Saint Joseph’s Health Centre and London Health Sciences Centre, at the
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27:
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Craven, Laura J.; Parvathy, Seema Nair; Tat-Ko, Justin; Burton, Jeremy P.; Silverman, Michael S. (6 November 2017).
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For his contributions to the fight against the global AIDS epidemic, Silverman was honoured by Ve'ahavta with the
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486:
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from mothers to infants. Similarly, Silverman undertook his humanitarian work in
Zimbabwe, through Ve'ahavta.
424:"Clinical Study of an Aluvia-based HAART Regimen for Prevention of Mother-to-child HIV Transmission in Africa"
742:
147:
772:
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during pregnancy and breastfeeding showed that it appeared to significantly prevent the transmission of
569:"Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial"
551:"Success of Self-Administered Home Fecal Transplantation for Chronic Clostridium difficile Infection"
62:
51:
182:
Silverman is involved in trying to reduce the incidence of life-threatening infections such as HIV,
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Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial
720:
586:
627:"Note to Harm Reduction Programs and Staff Regarding Recent HIV Research and 'Cook Your Wash'"
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695:"Surgery, counselling improve outcome for IV drug users with heart valve infection: study"
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249:"Toronto Jews take to streets and the Guyana rainforests to serve those in need"
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154:(FMT) from healthy donors are safe and show promise in improving response to
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469:"Food shortages in Zimbabwe sparked increase in tuberculosis, study finds"
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Treatment of metabolic disease and weight gain with fecal transplantation
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443:"In Africa, Rural Clinics Entice Pregnant Women With 'Baby Pictures'"
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the original director of medical operations with the organization.
676:"Researchers discover another way HIV can spread among drug users"
606:"Seeking an Obesity Cure Researchers Turn to the Gut Microbiome"
587:"Fecal transplants show promise in improving melanoma treatment"
107:
Silverman was one of the first North
American physicians to use
301:"On the Origin of the Treponematoses: A Phylogenetic Approach"
82:
282:"Antibiotic Resistance: Blame It on Lifesaving Malaria Drug?"
132:
In a world-first clinical trial published in the journal
251:. The Jewish News of Northern California. 20 April 2001.
352:"Isolated Tribe Gives Clues To The Origins Of Syphilis"
190:(a heart valve infection) in people who inject drugs.
16:
Canadian specialist in HIV/AIDS and infectious disease
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Work to protect injection drug Users from infection
46:Silverman demonstrated that the high prevalence of
386:"Genetic Study Bolsters Columbus Link to Syphilis"
371:"Columbus brought syphilis to Europe, study shows"
144:Centre hospitalier de l'Université de Montréal
38:Between 1994 and 2012, Silverman travelled to
549:Silverman; Davis; Pillai (October 31, 2023).
8:
61:in Europe after the discovery of America by
525:
326:
316:
604:O’Connor, JAnahad (10 September 2008).
384:Wilford, John Noble (15 January 2008).
222:
768:Canadian infectious disease physicians
467:Damjanovic, Jelena (5 February 2014).
743:"VE'AHAVTA HONOURS THE REPAIR PEOPLE"
741:Rosensweig, Avrum (1 December 2011).
621:
619:
489:. The Associated Press. 24 July 2009.
7:
487:"Zimbabwe's HIV infection rate down"
422:Silverman, Michael (17 March 2010).
369:Abraham, Carolyn (15 January 2008).
263:"Malaria drug may hit antibiotics"
14:
674:Dunham, Jackie (April 25, 2019).
280:Juncosa, Barbara (21 July 2008).
763:21st-century Canadian physicians
693:Long, Sacha (21 November 2018).
305:PLOS Neglected Tropical Diseases
140:Lawson Health Research Institute
409:Medicine, Conflict and Survival
235:Schulich Medicine and Dentistry
506:Open Forum Infectious Diseases
111:in the treatment of recurrent
30:, in London, Ontario, Canada.
1:
661:10.1016/S1473-3099(19)30705-4
28:University of Western Ontario
721:"Veahavta Tikun Olam Awards"
318:10.1371/journal.pntd.0000148
213:award for medicine in 2010.
152:fecal microbiota transplants
138:, a multi-centre study from
22:is a Canadian specialist in
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649:Lancet Infectious Diseases
158:in patients with advanced
103:with fecal transplantation
73:Silverman’s research in
745:. Canadian Jewish News.
148:Jewish General Hospital
441:McNeil Jr., Donald G.
231:"Michael S. Silverman"
20:Michael Seth Silverman
373:. The Globe and Mail.
350:Zimmer, Carl (2008).
109:fecal transplantation
63:Christopher Columbus
518:10.1093/ofid/ofx243
286:Scientific American
447:The New York Times
428:ClinicalTrials.gov
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473:U of T News
452:10 November
311:(1): e148.
211:Tikkun olam
757:Categories
705:24 January
701:. CTV News
217:References
199:infections
184:hepatitis
680:CTV News
634:catie.ca
555:Medscape
536:29255739
337:18235852
160:melanoma
59:syphilis
24:HIV/AIDS
527:5730934
328:2217670
48:malaria
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205:Awards
142:, the
75:Africa
40:Guyana
724:(PDF)
630:(PDF)
707:2019
532:PMID
454:2017
333:PMID
186:and
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522:PMC
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323:PMC
313:doi
267:BBC
83:HIV
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