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MOMP has been referred to as the point of no return for apoptosis, almost always resulting in the completion of the process, and thus, cell death. However, in limited circumstances, apoptosis does not complete. Sometimes, MOMP does not complete, known as incomplete MOMP (iMOMP) or minority MOMP
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of apoptosis, also known as the mitochondrial pathway. MOMP is known as the point of no return in apoptosis. Once triggered, it results in the diffusion of proteins from the space between the inner and outer mitochondrial membranes into the
73:(miniMOMP). For incomplete MOMP, mitochondrial membranes become permeable in most, but not all, the cell's mitochondria. In minority MOMP, only a few mitochondria of the cell experience MOMP—the result of sublethal stress.
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139:"Mitochondrial outer membrane permeabilization during apoptosis: The innocent bystander scenario"
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60:. The outer mitochondrial membrane, typically permeable to molecules smaller than 5 k
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Chipuk, J. E.; Bouchier-Hayes, L.; Green, D. R. (2006).
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Mitochondrial outer membrane permeabilization (MOMP)
191:"MOMP, cell suicide as a BCL-2 family business"
95:"Human Coronavirus: Host-Pathogen Interaction"
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189:Kalkavan, Halime; Green, Douglas R. (2018).
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21:mitochondrial outer membrane permeability
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112:10.1146/annurev-micro-020518-115759
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195:Cell Death & Differentiation
143:Cell Death & Differentiation
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99:Annual Review of Microbiology
48:Initiation of MOMP involves
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156:10.1038/sj.cdd.4401963
29:programmed cell death
23:, is one of two ways
207:10.1038/cdd.2017.179
52:proteins, including
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250:Mitochondria
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27:(a type of
239:Categories
77:References
245:Apoptosis
44:Mechanism
25:apoptosis
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216:5729535
68:Outcome
38:cytosol
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169:S2CID
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