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Nun Study

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192:. The purpose of the study was to conclude if activities, academics, past experiences, and disposition are correlated to continued cognitive, neurological, and physical ability as individuals got older, as well as overall longevity. The Nun Study participants were gathered on a volunteer basis following a presentation on the importance of donating one's brain for research purposes after death. Prior to the study's beginning, researchers required the participants to be cognitively intact and at least 75 years of age and for the Sisters to participate in the study until time of death. Participation in the study included the following; all participants gave permission for researchers to have access to their autobiographies and personal documented information and to participate in regular physical and mental examinations. These examinations were designed to test the subject's proficiency with object identification, memory, orientation, and language. These categories were tested through a series of mental state examinations with the data being recorded with each passing test. Nun Study participants were asked to give permission for their brains to be donated at time of death so that their brains could be neuropathologically evaluated for changes related to Alzheimer's disease and other dementias. Neuropathology evaluations for the Nun Study were performed by creating microscope slides from brain autopsy samples. Microscope slides that were created from the Nun Study brain autopsy samples were carefully evaluated for changes of Alzheimer's disease by specialized Physicians called Neuropathologists. 213:
researchers would evaluate the brains of the deceased to assess any brain pathology. Neuropathology evaluations for the Nun Study were performed by creating microscope slides from brain autopsy samples. Microscope slides that were created from the Nun Study brain autopsy samples were carefully evaluated for changes of Alzheimer's disease by specialized Physicians called Neuropathologists. The original Neuropathologist for the Nun Study was Dr. William Markesbery.
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who did not have higher education. Furthermore, the participants' word choice and vocabulary were also correlated to the development of Alzheimer's. Among the documents reviewed were autobiographical essays that were written by the nuns upon joining the sisterhood. Upon review, it was found that an essay's lack of
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disease in old age; meanwhile, of those whose writing was not lacking, only 10% later developed the disease. This was found when researchers examined neuropathology after nuns died, confirming that most of those who had a low idea density had Alzheimer's disease, and most of those with high idea density did not.
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fewer teeth were more likely to have dementia while living. Another study reaffirmed the findings of The Nun Study that higher idea density is correlated with better cognition during aging, even if the individual had brain lesions resembling those of Alzheimer's disease. A 2019 study combined The Nun Study and
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Hyman, Bradley T.; Phelps, Creighton H.; Beach, Thomas G.; Bigio, Eileen H.; Cairns, Nigel J.; Carrillo, Maria C.; Dickson, Dennis W.; Duyckaerts, Charles; Frosch, Matthew P.; Masliah, Eliezer; Mirra, Suzanne S.; Nelson, Peter T.; Schneider, Julie A.; Thal, Dietmar Rudolf; Thies, Bill (January 2012).
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Snowdon found that exercise was inversely correlated with development of Alzheimer's disease, showing that participants who engaged in some sort of daily exercise were more likely to retain cognitive abilities during aging. Participants who started exercising later in life were more likely to retain
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vocational lectures, indicating that the vocation and lifestyle of nuns correlated with higher potential for developing dementia. Using research from the original study, Weinstein et al. found a correlation between longevity, and autonomy. Subjects were shown to have a longer lifespan based on the
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One of the major findings from the nun study was how the participants' lifestyle and education may deter Alzheimer's symptoms. Participants who had an education level of a bachelor's degree or higher were less likely to develop Alzheimer's later in life. They also lived longer than their colleagues
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Snowdon and associates found three indicators of longer life when coding the sister's autobiographies: the number of positive sentences, positive words, and the variety of positive emotions used. The less positivity in writing correlated with greater mortality. There were many variables this study
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The Sisters' autobiographies written just before they took their vows (ages 19–21) revealed that positivity was closely related to longevity and idea density, which is related to conversation and writing. This research found that higher idea density scores correlated with a higher chance of having
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Researchers accessed the convent archive to review documents amassed throughout the lives of the nuns in the study. They also collected data via annual cognitive and physical function examinations conducted throughout the remainder of the participants' lives. After the death of a participant, the
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During the examination process Snowdon was able to compare the collected cognitive test scores with the neuropathology data that was obtained from examining the brains of the subject and quantifying microscopic changes. These results assisted in giving new layers of understanding to the nature of
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can help distinguish that some nondemented individuals fit the criteria for Alzheimer's disease. Researchers have also used the autopsy data to determine that there is a relationship between the number of teeth an individual has at death with how likely they were to have had dementia. Those with
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Montine, Thomas J.; Phelps, Creighton H.; Beach, Thomas G.; Bigio, Eileen H.; Cairns, Nigel J.; Dickson, Dennis W.; Duyckaerts, Charles; Frosch, Matthew P.; Masliah, Eliezer; Mirra, Suzanne S.; Nelson, Peter T.; Schneider, Julie A.; Thal, Dietmar Rudolf; Trojanowski, John Q.; Vinters, Harry V.
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The average age of nuns who began an autobiography was 22 years. Some participants who used more advanced words in their autobiography had less symptoms of Alzheimer's in older years. Roughly 80% of nuns whose writing was measured as lacking in linguistic density went on to develop Alzheimer's
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Overall, findings of the Nun Study indicated multiple factors concerning expression of Alzheimer's traits. The data primarily stated that age and disease do not always guarantee impaired cognitive ability and "that traits in early, mid, and late life have strong relationships with the risk of
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All Nun Study participants willingly signed a form agreeing to the terms of the study. As of 2017, there were three participants still living. Studying a relatively homogeneous group (no drug use, little or no alcohol, similar housing and reproductive histories) minimized the extraneous
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in 2021 under the directorship of Dr. Margaret Flanagan. The Nun Study is currently housed at the University of Texas Health San Antonio in the Bigg's Institute for Alzheimer's and Neurodegenerative diseases under the continued directorship of Neuropathologist, Dr. Margaret Flanagan.
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and hippocampus may have less of an effect than amyloid beta plaques located within those same areas. Another important factor was brain weight, as subjects with brains weighing under 1000 grams were seen as higher risk than those in a higher weight class.   
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Snowdon, David A.; Kemper, Susan J.; Mortimer, James A.; Greiner, Lydia H.; Wekstein, David R.; Markesbery, William R. (21 February 1996). "Linguistic Ability in Early Life and Cognitive Function and Alzheimer's Disease in Late Life: Findings From the Nun Study".
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The findings influenced other scientific studies and discoveries, one of which indicated that if a person has a stroke, there is a smaller requirement of Alzheimer's brain lesions necessary to diagnose a person with dementia. Another is that postmortem
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and Tau neurofibrillary tangles in the brain are required for the diagnosis of Alzheimer's Disease Neuropathologic Change to be made. Results from the Nun Study indicated that Tau neurofibrillary tangles located in regions of the brain outside the
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predictor of its author's risk for developing Alzheimer's disease in old age. However, the study also found that the Sisters who wrote positively in their personal journals were more likely to live longer than their counterparts.
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Riley, Kathryn P.; Snowdon, David A.; Desrosiers, Mark F.; Markesbery, William R. (March 2005). "Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study".
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Gosche, K. M.; Mortimer, J. A.; Smith, C. D.; Markesbery, W. R.; Snowdon, D. A. (28 May 2002). "Hippocampal volume as an index of Alzheimer neuropathology: Findings from the Nun Study".
1649:, 2001: Article contains, among other things, quotes from the nuns' autobiographical essays which may help to elucidate what is meant above by a "lack of linguistic density." 1406:
Stein, Pamela Sparks; Desrosiers, Mark; Donegan, Sara Jean; Yepes, Juan F.; Kryscio, Richard J. (1 October 2007). "Tooth loss, dementia and neuropathology in the Nun Study".
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Alzheimer's disease and other dementias. He concluded that Alzheimer's disease is likely caused by early childhood experiences or trauma instead of something from adulthood.
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was unable to glean from the autobiographies of the sisters, such as long term hopefulness or bleakness in one's personality, optimism, pessimism, ambition, and others.
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in 1990. In 2008, with Snowdon's retirement, the study returned to the University of Minnesota. The Nun Study was very briefly moved from the University of Minnesota to
1618: 1156:"National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach" 1696: 440: 612:
Sirts, Kairit; Piguet, Olivier; Johnson, Mark (1 June 2017). "Idea density for predicting Alzheimer's disease from transcribed speech".
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was established as a possible factor in Alzheimer's disease, but its presence did not predict disease with certainty. Existence of
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Tyas, Suzanne L.; Snowdon, David A.; Desrosiers, Mark F.; Riley, Kathryn P.; Markesbery, William R. (November 2007).
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sufficient mental capacity in late-life, despite neurological evidence that showed the onset of Alzheimer's disease.
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Iacono, D; Markesbery, W R.; Gross, M; Pletnikova, O; Rudow, G; Zandi, P; Troncoso, J C. (1 September 2009).
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Bennett, David A.; Schneider, Julie A.; Wilson, Zoe Arvanitakis and Robert S.; Wilson, RS (30 June 2012).
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Aging with Grace: What the Nun Study Teaches Us About Leading Longer, Healthier, and More Meaningful Lives
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Snowdon, David A. (2 September 2003). "Healthy Aging and Dementia: Findings from the Nun Study".
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Study Links Cognitive Ability of Youth With Alzheimer's Disease Risk Later in Life
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Weinstein, Netta; Legate, Nicole; Ryan, William S.; Hemmy, Laura (2019).
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amount of purposeful and reflective behavior shown in their writing.
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density (e.g., complexity, vivacity, fluency) functioned as a
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cognitive abilities, even if not having exercised before.
909: 656:"Overview and Findings from the Religious Orders Study" 184:. This study was focused on a group of 678 American 1662:
Agatha Christie And Nuns Tell A Tale Of Alzheimer's
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The Religious Orders Study was funded by the 1408:The Journal of the American Dental Association 880:10.7326/0003-4819-139-5_Part_2-200309021-00014 555: 553: 551: 849:"What Nuns Are Teaching Us About Alzheimer's" 505:Danner, DD; Snowdon, DA; Friesen, WV (2001). 8: 1496:Keohane, Kieran; Balfe, Myles (2017-08-25). 514:Journal of Personality and Social Psychology 1634:"Nuns Offer Clues to Alzheimer's and Aging" 1441:Keohane, Kieran; Balfe, Myles (July 2019). 439:Elizabeth Eisenstadt Evans (12 July 2021). 217:Writing, emotions, lifestyle and cognition 123:Nun Study of Aging and Alzheimer's Disease 1584: 1366: 1289: 1245: 1187: 966: 679: 617: 585: 129:, begun in 1986, to examine the onset of 109:Learn how and when to remove this message 1712:1986 establishments in the United States 990:Schmitt, F.; Thomason, P. (2010-07-06). 992:"William R. Markesbery, MD (1932-2010)" 422:"Nun Study to return to the University" 309: 800:"Neuropathology | Careers in Medicine" 636: 625: 172:in 1993, and was ongoing, as of 2012. 141:, later transferring the study to the 1037: 1035: 1033: 747: 745: 743: 7: 1057:10.1016/j.neurobiolaging.2004.06.019 500: 498: 496: 494: 351: 349: 347: 345: 343: 326:. New York, New York: Bantam Books. 317: 315: 313: 274:Alzheimer's disease, as well as the 47:adding citations to reliable sources 770:10.17723/aarc.67.1.d558520196w85573 14: 1087:"Physical exercise and dementia" 847:Sauer, Alissa (9 January 2017). 718:10.1001/jama.1996.03530310034029 478:Scholars @ UT Health San Antonio 397:"Offering an education in aging" 269:Conclusions and further research 188:Sisters who were members of the 23: 1420:10.14219/jada.archive.2007.0046 162:Rush Alzheimer's Disease Center 34:needs additional citations for 1089:. UK Alzheimer's Society. 2021 159:Rush University Medical Center 1: 828:UPMC | Life Changing Medicine 356:Moore, Bernardine A. (1995). 1697:School Sisters of Notre Dame 1340:School Sisters of Notre Dame 1008:10.1212/WNL.0b013e3181e73343 578:10.1212/WNL.0b013e3181b01077 395:Dunkel, Tom (18 June 2006). 190:School Sisters of Notre Dame 1656:National Institute on Aging 1616:Official Nun Study homepage 1612:Official Nun Study homepage 868:Annals of Internal Medicine 182:National Institute on Aging 170:National Institute on Aging 166:Rush Religious Orders Study 16:Alzheimer's article on nuns 1733: 1658:, entry on Nun Study, 1996 1230:10.1016/j.jalz.2011.10.007 1218:Alzheimer's & Dementia 804:careersinmedicine.aamc.org 672:10.2174/156720512801322573 660:Current Alzheimer Research 526:10.1037/0022-3514.80.5.804 322:Snowdon, David A. (2002). 1172:10.1007/s00401-011-0910-3 462:https://katoactonalz.org/ 1514:10.1177/1471301217725186 1459:10.1177/1471301217725186 157:In 1992, researchers at 1291:10.1093/geront/37.2.150 1269:Snowdon, David (1997). 443:. Global Sisters Report 251:In 1992, a gene called 147:Northwestern University 139:University of Minnesota 1692:Psychology experiments 1672:Religious Orders Study 1557:Journal of Personality 1377:10.1212/WNL.58.10.1476 758:The American Archivist 635:Cite journal requires 280:cognitive disabilities 143:University of Kentucky 1160:Acta Neuropathologica 1045:Neurobiology of Aging 951:10.1093/ageing/afm120 474:"Margaret E Flanagan" 362:Public Health Reports 257:amyloid beta plaques 176:Origin and procedure 43:improve this article 1702:Alzheimer's disease 1643:by Pam Belluck for 1127:. pp. 121–123. 874:(5_Part_2): 450–4. 428:. 23 February 2009. 426:The Minnesota Daily 131:Alzheimer's disease 1639:2009-09-25 at the 1621:2018-03-29 at the 1569:10.1111/jopy.12379 127:longitudinal study 1627:Nun study video: 1414:(10): 1314–1322. 1361:(10): 1476–1482. 1278:The Gerontologist 119: 118: 111: 93: 1724: 1599: 1598: 1588: 1548: 1542: 1541: 1508:(5): 1651–1662. 1493: 1487: 1486: 1453:(5): 1651–1662. 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Index


verification
improve this article
adding citations to reliable sources
"Nun Study"
news
newspapers
books
scholar
JSTOR
Learn how and when to remove this message
longitudinal study
Alzheimer's disease
David Snowdon
University of Minnesota
University of Kentucky
Northwestern University
Rush University Medical Center
Rush Alzheimer's Disease Center
Rush Religious Orders Study
National Institute on Aging
National Institute on Aging
Roman Catholic
School Sisters of Notre Dame
variables
linguistic
significant
apolipoprotein E
amyloid beta plaques
neocortex

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