177:
schwannomatosis, however, is minimal (approximately 5 percent of cases). These tumors might lack a capsule or be less encapsulated than a typical schwannoma.More challenging to identify from MPNST are the infrequent plexiform schwannomas that develop in deep anatomical sites, such as soft tissue or major peripheral nerves. These tumors may exhibit enhanced cellularity and mitotic activity. Although the likelihood of these tumors developing into cancer is extremely low, local recurrence is possible in around half of cases. On MRI, it usually shows hyper or iso-intensity on T1-weighted images and heterogenous hyperintensities on T2 weighted images. Pleural schwannoma typically shows fatty degeneration, hemorrhage, perivascular hyalinization, and cystic formation thus giving heterogenous hyperintensities on T2 weighted images. Complete surgical removal of pleural schwannoma is the usual treatment.
244:
278:
232:
51:
223:
214:
269:
260:
110:
Schwannomas are homogeneous tumors, consisting only of
Schwann cells. The tumor cells always stay on the outside of the nerve, but the tumor itself may either push the nerve aside and/or up against a bony structure (thereby possibly causing damage). Schwannomas are relatively slow-growing. For
183:
is a relatively rare variation. Cellular schwannoma is nearly exclusively made up of a fascicular proliferation of well-differentiated
Schwann cells that are cytologically bland, missing Verocay bodies, and just slightly exhibiting Antoni B pattern growth (10% of the tumor area). Local
176:
is extremely rare. A unique subtype of schwannoma that typically develops in superficial (cutaneous or subcutaneous) sites and may be identified by its development pattern, which is plexiform (intraneuralnodular). The correlation with schwannoma predisposition disorders like NF2 and
194:) is a rare aggressive peripheral nerve sheath tumor that typically develops in conjunction with spinal or visceral autonomic nerves, consisting uniformly of Schwann cells displaying melanocytic differentiation. About half of the cases are associated with
746:
731:
538:
Hebert-Blouin MN, Amrami KK, Scheithauer BW, Spinner RJ. Multinodular/plexiform (multifascicular) schwannomas of major peripheral nerves: an underrecognized part of the spectrum of schwannomas. J Neurosurg. 2010; 112:372–382.
296:
243:
157:
and hearing loss on the affected side. Outside the cranial nerves, schwannomas may present on the flexor surfaces of the limbs. Rare occurrences of these tumors in the penis have been documented in the literature.
642:
Casadei GP, Scheithauer BW, Hirose T, Manfrini M, Van Houton C, Wood MB. Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. Cancer. 1995; 75:1109–1119.
599:
Casadei GP, Scheithauer BW, Hirose T, Manfrini M, Van Houton C, Wood MB. Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. Cancer. 1995; 75:1109–1119.
1291:
1191:
909:
850:
505:
Woodruff JM, Marshall ML, Godwin TA, Funkhouser JW, Thompson NJ, Erlandson RA. Plexiform (multinodular) schwannoma. A tumor simulating the plexiform neurofibroma. Am J Surg Pathol. 1983; 7:691–697.
514:
Berg JC, Scheithauer BW, Spinner RJ, Allen CM, Koutlas IG. Plexiform schwannoma: a clinicopathologic overview with emphasis on the head and neck region. Hum Pathol. 2008; 39:633–640.
761:
523:
Agaram, N. P.; Prakash, S.; Antonescu, C. R.; "Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety",
822:
633:
White W, Shiu MH, Rosenblum MK, Erlandson RA, Woodruff JM. Cellular schwannoma. A clinicopathologic study of 57 patients and 58 tumors. Cancer. 1990; 66:1266–1275.
1154:
496:
Fletcher CD, Davies SE. Benign plexiform (multinodular) schwannoma: a rare tumour unassociated with neurofibromatosis. Histopathology. 1986; 10:971–980.
145:
Schwannomas of the head and neck are a fairly common occurrence and can be found incidentally in 3–4% of patients at autopsy. Most common of these is a
618:
Wick, M. R.; Swanson, P. E.; Scheithauer, B. W.; Manivel, J. C.; "Malignant peripheral nerve sheath tumor: An immunohistochemical study of 62 cases",
1331:
1275:
1199:
1123:
620:
525:
365:
335:
291:
231:
961:
815:
419:
Hanemann CO, Evans DG (December 2006). "News on the genetics, epidemiology, medical care and translational research of
Schwannomas".
462:
Nguyen AH, Smith ML, Maranda EL, Punnen S (June 2016). "Clinical
Features and Treatment of Penile Schwannoma: A Systematic Review".
1149:
808:
306:
609:
Fletcher CD, Davies SE, McKee PH. Cellular schwannoma: a distinct pseudosarcomatous entity. Histopathology. 1987; 11:21–35.
956:
1128:
655:"Malignant melanotic nerve sheath tumors in the spinal canal of psammomatous and non-psammomatous type: Two case reports"
1001:
277:
381:
Biswas D, Marnane CN, Mal R, Baldwin D (September 2007). "Extracranial head and neck schwannomas--a 10-year review".
50:
213:
1213:
127:
104:
1052:
1047:
839:
772:
222:
61:
of a schwannoma showing both a cellular Antoni A area (top) and a loose paucicellular Antoni B area (bottom).
831:
150:
1326:
1303:
Note: Not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see
971:
966:
900:
268:
259:
1268:
1227:
951:
146:
1232:
1042:
1075:
750:
123:. These masses are generally contained within a capsule, so surgical removal is often successful.
1239:
1181:
444:
92:
1252:
996:
861:
783:
694:
676:
582:
479:
436:
398:
361:
331:
139:
120:
70:
1304:
1070:
684:
666:
572:
562:
471:
428:
390:
131:
1144:
988:
1113:
1104:
1034:
766:
689:
654:
577:
550:
250:
195:
75:
755:
653:
Yeom, Jeong A; Song, You Seon; Lee, In Sook; Han, In Ho; Choi, Kyung Un (2022-08-26).
1320:
1222:
1108:
1024:
135:
100:
448:
1259:
1247:
976:
919:
301:
161:
96:
777:
1118:
1080:
946:
914:
866:
800:
788:
671:
475:
1176:
1019:
740:
432:
394:
184:
recurrence is
Variable (5-40%) and perhaps greater than in normal schwannomas.
58:
680:
567:
938:
886:
698:
586:
483:
440:
402:
1168:
1011:
154:
62:
17:
723:
297:
List of inclusion bodies that aid in diagnosis of cutaneous conditions
1096:
929:
735:
116:
112:
130:, which may be due to a loss-of-function mutation in the protein
804:
115:
and less than 1% become malignant, degenerating into a form of
1292:
WHO classification of the tumors of the central nervous system
328:
Andrews' diseases of the skin : clinical dermatology
44:
neurilemoma, neuroma, neurolemoma, Schwann cell tumor
713:
551:"Giant ancient schwannoma of the pleura: Commentary"
1284:
1212:
1190:
1167:
1137:
1093:
1063:
1033:
1010:
987:
937:
928:
908:
899:
875:
847:
838:
717:
111:reasons not yet understood, schwannomas are mostly
69:
40:
35:
27:
Benign nerve-sheath tumor composed of
Schwann cells
330:(10th ed.). Philadelphia: Saunders Elsevier.
816:
8:
414:
412:
1155:Embryonal tumour with multilayered rosettes
356:Rapini RP, Bolognia JL, Jorizzo JL (2007).
934:
925:
905:
844:
823:
809:
801:
714:
351:
349:
347:
49:
32:
688:
670:
576:
566:
138:positive, which is a marker for cells of
164:are seen histologically in schwannomas.
99:, which normally produce the insulating
1276:Malignant peripheral nerve sheath tumor
1200:Primary central nervous system lymphoma
1124:Dysembryoplastic neuroepithelial tumour
318:
209:
621:American Journal of Clinical Pathology
526:American Journal of Clinical Pathology
188:Malignant melanotic nerve sheath tumor
326:James WD, Berger T, Elston D (2006).
292:Intranodal palisaded myofibroblastoma
7:
962:Subependymal giant cell astrocytoma
126:Schwannomas can be associated with
25:
249:Antoni A area of schwannoma with
1150:Atypical teratoid rhabdoid tumor
276:
267:
258:
242:
230:
221:
212:
1332:Dermal and subcutaneous growths
659:World Journal of Clinical Cases
1244:Cranial and paraspinal nerves
307:Palisaded encapsulated neuroma
1:
957:Pleomorphic xanthoastrocytoma
832:Tumours of the nervous system
464:Clinical Genitourinary Cancer
1002:Anaplastic oligodendroglioma
1348:
672:10.12998/wjcc.v10.i24.8735
476:10.1016/j.clgc.2015.12.018
1300:
433:10.1007/s00415-006-0347-0
395:10.1016/j.anl.2007.01.006
358:Dermatology: 2-Volume Set
253:(one annotated by circle)
128:neurofibromatosis type II
57:
48:
1129:Lhermitte–Duclos disease
1053:Choroid plexus carcinoma
1048:Choroid plexus papilloma
568:10.4103/0970-2113.184928
134:. They are universally
237:Subcutaneous schwannoma
151:vestibulocochlear nerve
972:Anaplastic astrocytoma
967:Fibrillary astrocytoma
91:) is a usually benign
1228:Esthesioneuroblastoma
952:Pilocytic astrocytoma
529:, 29:1042–1048, 2005
190:(previously known as
147:vestibular schwannoma
1233:Ganglioneuroblastoma
1138:CNS embryonal tumors
1043:Choroid plexus tumor
421:Journal of Neurology
383:Auris, Nasus, Larynx
360:. St. Louis: Mosby.
192:melanotic schwannoma
1076:Gliomatosis cerebri
624:, 87:425–433, 1987
181:Cellular schwannoma
1240:Nerve sheath tumor
1182:Hemangiopericytoma
549:Iwasaki T (2016).
174:Pleural schwannoma
93:nerve sheath tumor
1314:
1313:
1253:Neurofibromatosis
1208:
1207:
1163:
1162:
1089:
1088:
997:Oligodendroglioma
895:
894:
862:Craniopharyngioma
798:
797:
665:(24): 8735–8741.
427:(12): 1533–1541.
367:978-1-4160-2999-1
337:978-0-7216-2921-6
153:that may lead to
149:, a tumor of the
140:neural crest cell
121:neurofibrosarcoma
105:peripheral nerves
81:
80:
30:Medical condition
16:(Redirected from
1339:
1305:brain metastasis
1269:Acoustic neuroma
1071:Oligoastrocytoma
1064:Multiple/unknown
935:
926:
906:
880:
855:
845:
825:
818:
811:
802:
715:
703:
702:
692:
674:
650:
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634:
631:
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610:
607:
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570:
546:
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459:
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416:
407:
406:
378:
372:
371:
353:
342:
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280:
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262:
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234:
225:
216:
53:
33:
21:
1347:
1346:
1342:
1341:
1340:
1338:
1337:
1336:
1317:
1316:
1315:
1310:
1309:
1296:
1280:
1204:
1186:
1159:
1145:Medulloblastoma
1133:
1095:
1085:
1059:
1029:
1006:
989:Oligodendrocyte
983:
918:
912:
910:Neuroepithelial
891:
876:
871:
848:
834:
829:
799:
794:
793:
726:
712:
707:
706:
652:
651:
647:
641:
637:
632:
628:
617:
613:
608:
604:
598:
594:
548:
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537:
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518:
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491:
461:
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418:
417:
410:
380:
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375:
368:
355:
354:
345:
338:
325:
324:
320:
315:
288:
281:
272:
263:
254:
247:
238:
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226:
217:
208:
202:
170:
31:
28:
23:
22:
15:
12:
11:
5:
1345:
1343:
1335:
1334:
1329:
1319:
1318:
1312:
1311:
1301:
1298:
1297:
1295:
1294:
1288:
1286:
1282:
1281:
1279:
1278:
1273:
1272:
1271:
1257:
1256:
1255:
1250:
1242:
1237:
1236:
1235:
1230:
1219:
1217:
1210:
1209:
1206:
1205:
1203:
1202:
1196:
1194:
1188:
1187:
1185:
1184:
1179:
1173:
1171:
1165:
1164:
1161:
1160:
1158:
1157:
1152:
1147:
1141:
1139:
1135:
1134:
1132:
1131:
1126:
1121:
1116:
1114:Retinoblastoma
1111:
1105:Ganglioneuroma
1101:
1099:
1091:
1090:
1087:
1086:
1084:
1083:
1078:
1073:
1067:
1065:
1061:
1060:
1058:
1057:
1056:
1055:
1050:
1039:
1037:
1035:Choroid plexus
1031:
1030:
1028:
1027:
1022:
1016:
1014:
1008:
1007:
1005:
1004:
999:
993:
991:
985:
984:
982:
981:
980:
979:
974:
969:
964:
959:
954:
943:
941:
932:
923:
903:
897:
896:
893:
892:
890:
889:
883:
881:
873:
872:
870:
869:
864:
858:
856:
842:
836:
835:
830:
828:
827:
820:
813:
805:
796:
795:
792:
791:
780:
769:
758:
743:
727:
722:
721:
719:
718:Classification
711:
710:External links
708:
705:
704:
645:
635:
626:
611:
602:
592:
541:
531:
516:
507:
498:
489:
470:(3): 198–202.
454:
408:
389:(3): 353–359.
373:
366:
343:
336:
317:
316:
314:
311:
310:
309:
304:
299:
294:
287:
284:
283:
282:
275:
273:
266:
264:
257:
255:
251:Verocay bodies
248:
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236:
229:
227:
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211:
207:
204:
200:
199:
196:Carney complex
185:
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169:
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162:Verocay bodies
79:
78:
76:Neuro-oncology
73:
67:
66:
55:
54:
46:
45:
42:
38:
37:
29:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1344:
1333:
1330:
1328:
1327:PNS neoplasia
1325:
1324:
1322:
1308:
1306:
1299:
1293:
1290:
1289:
1287:
1283:
1277:
1274:
1270:
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1266:
1265:
1261:
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1246:
1245:
1243:
1241:
1238:
1234:
1231:
1229:
1226:
1225:
1224:
1223:Neuroblastoma
1221:
1220:
1218:
1215:
1211:
1201:
1198:
1197:
1195:
1193:
1192:Hematopoietic
1189:
1183:
1180:
1178:
1175:
1174:
1172:
1170:
1166:
1156:
1153:
1151:
1148:
1146:
1143:
1142:
1140:
1136:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1109:Ganglioglioma
1106:
1103:
1102:
1100:
1098:
1092:
1082:
1079:
1077:
1074:
1072:
1069:
1068:
1066:
1062:
1054:
1051:
1049:
1046:
1045:
1044:
1041:
1040:
1038:
1036:
1032:
1026:
1025:Subependymoma
1023:
1021:
1018:
1017:
1015:
1013:
1009:
1003:
1000:
998:
995:
994:
992:
990:
986:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
949:
948:
945:
944:
942:
940:
936:
933:
931:
927:
924:
921:
920:spinal tumors
916:
911:
907:
904:
902:
898:
888:
885:
884:
882:
879:
874:
868:
865:
863:
860:
859:
857:
854:
852:
846:
843:
841:
837:
833:
826:
821:
819:
814:
812:
807:
806:
803:
790:
786:
785:
781:
779:
775:
774:
770:
768:
764:
763:
759:
757:
753:
752:
748:
744:
742:
738:
737:
733:
729:
728:
725:
720:
716:
709:
700:
696:
691:
686:
682:
678:
673:
668:
664:
660:
656:
649:
646:
639:
636:
630:
627:
623:
622:
615:
612:
606:
603:
596:
593:
588:
584:
579:
574:
569:
564:
561:(4): 449–50.
560:
556:
552:
545:
542:
535:
532:
528:
527:
520:
517:
511:
508:
502:
499:
493:
490:
485:
481:
477:
473:
469:
465:
458:
455:
450:
446:
442:
438:
434:
430:
426:
422:
415:
413:
409:
404:
400:
396:
392:
388:
384:
377:
374:
369:
363:
359:
352:
350:
348:
344:
339:
333:
329:
322:
319:
312:
308:
305:
303:
300:
298:
295:
293:
290:
289:
285:
279:
274:
270:
265:
261:
256:
252:
245:
240:
233:
228:
224:
219:
215:
210:
205:
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197:
193:
189:
186:
182:
179:
175:
172:
171:
167:
165:
163:
159:
156:
152:
148:
143:
141:
137:
133:
129:
124:
122:
118:
114:
108:
106:
102:
101:myelin sheath
98:
97:Schwann cells
94:
90:
86:
77:
74:
72:
68:
64:
60:
56:
52:
47:
43:
39:
34:
19:
1302:
1263:
1260:Neurilemmoma
1248:Neurofibroma
977:Glioblastoma
915:brain tumors
877:
849:
782:
771:
760:
745:
730:
662:
658:
648:
638:
629:
619:
614:
605:
595:
558:
554:
544:
534:
524:
519:
510:
501:
492:
467:
463:
457:
424:
420:
386:
382:
376:
357:
327:
321:
302:Neurofibroma
201:
191:
187:
180:
173:
160:
144:
125:
109:
95:composed of
89:neurilemmoma
88:
84:
82:
1119:Neurocytoma
1081:Gliosarcoma
947:Astrocytoma
867:Pituicytoma
41:Other names
1321:Categories
1264:Schwannoma
1177:Meningioma
1020:Ependymoma
784:DiseasesDB
555:Lung India
313:References
85:schwannoma
59:Micrograph
36:Schwannoma
939:Astrocyte
887:Pinealoma
840:Endocrine
681:2307-8960
119:known as
103:covering
71:Specialty
18:Neurinoma
1169:Meninges
1012:Ependyma
699:36157803
587:27578944
484:26797586
449:11854280
441:17219030
403:17376620
286:See also
168:Variants
155:tinnitus
142:origin.
63:HE stain
778:D009442
767:M9560/0
690:9453363
578:4948239
206:Gallery
1097:neuron
1094:Mature
930:Glioma
878:Other:
851:Sellar
697:
687:
679:
585:
575:
482:
447:
439:
401:
364:
334:
132:merlin
117:cancer
113:benign
1285:Other
789:33713
762:ICD-O
756:225.1
741:C72.4
445:S2CID
136:S-100
773:MeSH
751:9-CM
695:PMID
677:ISSN
583:PMID
480:PMID
437:PMID
399:PMID
362:ISBN
332:ISBN
87:(or
1214:PNS
901:CNS
747:ICD
732:ICD
685:PMC
667:doi
573:PMC
563:doi
472:doi
429:doi
425:253
391:doi
1323::
1307:).
1107::
787::
776::
765::
754::
739::
736:10
693:.
683:.
675:.
663:10
661:.
657:.
581:.
571:.
559:33
557:.
553:.
478:.
468:14
466:.
443:.
435:.
423:.
411:^
397:.
387:34
385:.
346:^
107:.
83:A
1262:/
1216::
922:)
917:,
913:(
853::
824:e
817:t
810:v
749:-
734:-
724:D
701:.
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