272:, France. She was an only child, raised by both parents in the town of Lorient, where her mother worked as a schoolteacher and her father as a businessman. In 1944 she fled her hometown temporarilyand attended a boarding school in Nantes to escape the invading German forces, before moving back after the end of World War II to her high school in Lorient. She graduated in 1949. In high school and in her first year at university she was oriented towards literature but the influence of a talented science teacher in her last year at school turned her interests to natural sciences. She met her future husband while in high school and they both moved to Paris where they attended the same university and married in 1951. She received her B.S. in natural sciences from the Sorbonne in 1954. She did not immediately continue to graduate work, choosing instead to teach high school science and raise her two daughters. In 1958, she returned to the university to continue her education at the
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that the quail cell nucleoli were significantly larger and denser than the chicken cell nucleoli. The size disparity was caused by the tendency of quail embryos to carry increased amount of heterochromatin in the nucleolus. Le
Douarin was able to utilize Feulgen stain to stain the heterochromatin and distinguish between groups of quail-derived and chicken-derived cells in her chimeric embryos based on the amount of visible dye. The use of Feulgen stain was an important turning point in Le Douarin's research, as she was now able to track specific quail cell fates in the developing embryo. When creating embryos of combined quail and chick cells, she could trace the differentiation of separate cell lines throughout the developing organism.
309:
stain technique allowed for the creation of a fate map detailing the migration of the quail-derived neural crest cells. This research spurred Le
Douarin to publish her first book, The Neural Crest, in 1982. In the following years, she would gain membership to the French Academy of Science, and receive the Kyoto Prize in Advanced Technology for her work with avian chimeras. Throughout the late 1980s and early 1990s, Le Douarin would be admitted to multiple highly regarded scientific societies and received many additional awards in her field, including the Louis-Jeantet Prize for Medicine, the Louisa Gross Horwitz Prize, and the Pearl Meister Greengard Prize.
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She was appointed to the faculty at the
University of Nantes in 1966. The dean, however, almost disallowed her appointment because he disapproved of married women on the same faculty with their husbands. Le Douarin's mentor Wolf intervened, and the dean relented. However, she was not given laboratory
260:. Her technique has also permitted her to shed light on the development of the blood and immune systems. Her work on antero-posterior patterning of the vertebrate digestive tract laid the grounds for future work, leading to a better understanding of antero-posterior patterning in the digestive tract.
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Le
Douarin was most interested in researching embryonic inductive signaling mechanisms. Through years of experimentation, she invented an embryo manipulation technology to produce chimeric embryos from chicken and quails. When grafting quail mesoderm and chicken endoderm together, Le Douarin noticed
308:
Institute of
Embryology. Building on her past experimentation, she began to research the developmental mechanism of the neural crest of avian embryos. In a 1980 publication, Le Douarin detailed her process of inserting totipotent quail nerve cells into the neural primordium of a chick. Her Feulgen
312:
Le
Douarin was Director of the Institute of Embryology at the C.N.R.S., replacing her mentor Etienne Wolf. James Ebert, an embryologist at the Carnegie Institution of Washington, recommended her to the position. She is notable for her work on the development of higher animal nervous and immune
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Le
Douarin N & Teillet M. "Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neuroectodermal mesenchymal derivatives using a biological cell marking technique."
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manipulation technology to produce chimeric embryos, from chicken and quails. Her research has shed light on the development of higher animal nervous and immune systems. She showed that precursor cells within the
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space or a research budget, as her husband was, and she was given a heavy teaching load. Le
Douarin continued her research on avian embryos, focusing on the interactions between the
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Le
Douarin's work on chimeric embryos became increasingly notable, and she was able to gain international funding for her research after being appointed as Director of the
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systems, mechanisms of evolution in developmental biology and vertebrate central nervous system development. Her work has been used in research on songbird behavior.
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336:"Mapping of the Early Neural Primordium in Quail-Chick Chimaeras: I. Developmental Relationship between Placodes, Facial Ectoderm and Proscephalon" (1985)
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560:"Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis"
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511:"Developmental hematopoiesis: historical background and perspectives. An interview with Nicole Le Douarin"
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330:"Tracing of Cells of the Avian Thymus through Embryonic Life in Interspecific Chimaeras" (1975)
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712:"Nicole Marthe Le Douarin (1930- ) | The Embryo Project Encyclopedia"
639:"Nicole Marthe Le Douarin (1930- ) – The Embryo Project Encyclopedia"
248:
274:
Institut d’Embryologie Centre national de la recherche scientifique
342:"Cell line segregation during peripheral nervous system ontogeny"
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236:, which have led to critical insights regarding higher animal
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from the article and its talk page, especially if potentially
20:
413:(Le Douarin was only the third woman admitted in its history)
280:. This research led to her doctoral work and Ph.D. in 1964.
1284:
Fellows of the
Academy of Medical Sciences (United Kingdom)
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Foreign associates of the National Academy of Sciences
349:
N. M. Le Douarin, S. Creuzet, G. Couly, and E. Dupin,
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Fellows of the American Academy of Arts and Sciences
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665:The International Journal of Developmental Biology
564:The International Journal of Developmental Biology
515:The International Journal of Developmental Biology
451:International Society of Developmental Biologists
892:Official site of the Louisa Gross Horwitz Prize
400:in Biotechnology and Medical Technology (1986)
351:Neural crest cell plasticity and its limits,"
927:
8:
1309:Members of the Brazilian Academy of Sciences
897:Dr. Le Douarin videos of chick-quail embryos
1314:Members of the National Academy of Medicine
509:Durand, Charles; Jaffredo, Thierry (2010).
276:(CNRS), working with renowned embryologist
934:
920:
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58:about living persons that is unsourced or
1279:Members of the French Academy of Sciences
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658:"A life in Science with the avian embryo"
575:
526:
268:Le Douarin was born on 20 August 1930 in
129:Learn how and when to remove this message
762:"Nicole Marthe Le Douarin | Kyoto Prize"
741:American Academy of Arts & Sciences
490:
371:European Molecular Biology Organization
1274:Kyoto laureates in Advanced Technology
480:(2004) (inaugural winner of the Prize)
366:Prix de l'Académie des Sciences (1965)
789:Gruss, P. (August 1997). "Laudatio".
784:
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392:American Academy of Arts and Sciences
7:
1269:Foreign members of the Royal Society
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704:
605:
603:
1182:Edward Shackleton, Baron Shackleton
1304:Recipients of the Legion of Honour
618:The Ponfifical Academy of Sciences
14:
833:"Academia Brasileira de Ciencias"
866:
424:Louis-Jeantet Prize for Medicine
217:Louis-Jeantet Prize for Medicine
25:
899:at Developmental Biology Online
327:v. 41, pp. 162–184 (1974).
1254:21st-century French biologists
656:Le Douarin, Nicole M. (2018).
458:Pontifical Academy of Sciences
1:
803:10.1016/S0925-4773(97)83771-9
611:"Nicole Marthe C. Le Douarin"
478:Pearl Meister Greengard Prize
472:Brazilian Academy of Sciences
431:Royal College of Pathologists
558:Grapin-Botton, Anne (2005).
36:biography of a living person
1061:Andrew David McLachlan
465:Academy of Medical Sciences
228:(born 20 August 1930) is a
63:must be removed immediately
1330:
737:"Nicole Marthe Le Douarin"
437:Louisa Gross Horwitz Prize
385:French Academy of Sciences
78:"Nicole Marthe Le Douarin"
903:Tribute to Dr. Le Douarin
879:Nicole Marthe Le Douarin
791:Mechanisms of Development
333:"The Neural Crest" (1982)
264:Early years and education
232:known for her studies of
150:
1264:Developmental biologists
1198:Nicole Marthe Le Douarin
1055:Gilbert George Lonzarich
226:Nicole Marthe Le Douarin
145:Nicole Marthe Le Douarin
1294:French women scientists
1259:French women biologists
1116:John Philip Simons
1103:John Martin Rowell
467:in Great Britain (2002)
247:Le Douarin invented an
230:developmental biologist
192:Developmental biologist
1082:Robert Ladislav Parker
355:131, 4637-4650 (2004).
50:Please help by adding
1110:Ian John Russell
678:10.1387/ijdb.170287NL
577:10.1387/ijdb.041946ag
528:10.1387/ijdb.103154cd
429:Honorary Fellow, The
1223:Edward Mills Purcell
56:Contentious material
1156:Thomas Summers West
498:Louis-Jeantet Prize
447:Ross Harrison Prize
441:Columbia University
1218:Barbara McClintock
1005:Peter Goddard
876:has a profile for
460:(3 September 1999)
317:Significant papers
157:Le Douarin in 2013
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1161:Andrew Wiles
1126:Marshall Stoneham
882:
463:Honorary Fellow,
418:The Royal Society
411:Collège de France
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39:needs additional
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1151:Rob Webster
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970:Kenneth Bagshawe
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1141:Kenneth Wade
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1097:Warren Roper
1092:Richard Peto
1087:Geoff Parker
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975:John M. Ball
878:
845:. Retrieved
841:the original
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797:(1–2): 3–4.
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254:neural crest
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45:verification
38:
15:
1244:1930 births
1072:Kim Nasmyth
1030:Julian Hunt
990:Arthur Cain
980:Adrian Bird
398:Kyoto Prize
353:Development
258:multipotent
212:Kyoto Prize
1238:Categories
1203:Paul Erdős
1175:Statute 12
1077:Paul Nurse
1025:Derek Hull
1015:Brian Heap
995:Mark Child
847:2 December
837:abc.org.br
485:References
325:Dev. Biol.
188:Occupation
169:1930-08-20
89:newspapers
881:(Q457343)
687:0214-6282
586:0214-6282
537:0214-6282
41:citations
1146:Pat Wall
949:elected
819:11468110
695:29616728
594:15906249
545:20711976
470:Member,
456:Member,
416:Fellow,
409:Member,
390:Member,
383:Member,
376:Member,
369:Member,
306:C.N.R.S.
297:layers.
295:mesoderm
291:endoderm
234:chimeras
202:Chimeras
182:, France
67:libelous
1191:Foreign
958:Fellows
951:in 1989
945:of the
943:Fellows
874:Scholia
811:9376321
771:13 July
746:13 July
721:13 July
623:13 July
344:Science
270:Lorient
238:nervous
180:Lorient
103:scholar
817:
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693:
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474:(2002)
453:(1997)
443:(1993)
433:(1993)
426:(1990)
420:(1989)
406:(1986)
394:(1984)
387:(1982)
380:(1980)
373:(1977)
361:Awards
346:(1986)
284:Career
249:embryo
219:(1990)
214:(1986)
208:Awards
105:
98:
91:
84:
76:
815:S2CID
661:(PDF)
614:(PDF)
449:from
439:from
256:were
110:JSTOR
96:books
34:This
849:2011
807:PMID
773:2020
748:2020
723:2020
691:PMID
683:ISSN
625:2020
590:PMID
582:ISSN
541:PMID
533:ISSN
293:and
240:and
163:Born
82:news
43:for
905:by
799:doi
766:京都賞
673:doi
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107:·
100:·
93:·
86:·
69:.
48:.
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