Knowledge (XXG)

Nizofenone

Source ๐Ÿ“

219: 844: 29: 679:
Saito I, Asano T, Ochiai C, Takakura K, Tamura A, Sano K (1983). "A double-blind clinical evaluation of the effect of Nizofenone (Y-9179) on delayed ischemic neurological deficits following aneurysmal rupture".
404:
Ohta T, Kikuchi H, Hashi K, Kudo Y (March 1986). "Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study".
781:
Yasuda H, Nakanishi M, Tsumagari T, Nakajima A, Nakanishi M (November 1979). "The mechanism of action of a novel cerebral protective drug against anoxia I. The effect on cerebral energy demand".
59: 889: 804:"Protection from cerebral ischemia by a new imidazole derivative (Y-9179) and pentobarbital. A comparative study in chronic middle cerebral artery occlusion in cats" 295: 41: 309: 507:
Matsumoto Y, Aihara K, Kamata T, Goto N (September 1994). "Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation".
882: 456: 613:
Yasuda H, Kishiro K, Izumi N, Nakanishi M (July 1985). "Biphasic liberation of arachidonic and stearic acids during cerebral ischemia".
933: 923: 908: 875: 329: 711:"Mechanisms of cerebral protection by pentobarbital and nizofenone correlated with the course of local cerebral blood flow changes" 337:
InChI=1S/C21H21ClN4O3/c1-3-24(4-2)14-20-23-11-12-25(20)19-10-9-15(26(28)29)13-17(19)21(27)16-7-5-6-8-18(16)22/h5-13H,3-4,14H2,1-2H3
383:(interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as 928: 92: 178: 198: 744:
Yasuda H, Shimada O, Nakajima A, Asano T (October 1981). "Cerebral protective effect and radical scavenging action".
439:
Yasuda H, Izumi N, Nakanishi M, Maruyama Y (1988). "Brain Protection Against Oxygen Deficiency by Nizofenone".
592:
Hayashi Y, Shimada O, Yasuda H, Ikegami K (1994). "Effect of nizofenone on experimental head trauma in mice".
650:
Yasuda H, Ochi H, Tsumagari T (September 1984). "Stimulation of prostacyclin synthesis by nizofenone".
556: 214: 913: 851: 113: 769: 638: 580: 825: 790: 761: 732: 697: 667: 630: 601: 572: 524: 489: 462: 452: 421: 859: 918: 815: 753: 722: 689: 659: 622: 564: 516: 444: 413: 235: 843: 547:
Yasuda H (1999). "Prevention of neurodegeneration by a neuroprotective radical scavenger".
187: 122: 380: 376: 218: 167: 560: 855: 757: 626: 568: 480:
Yasuda H, Nakajima A (1993). "Brain protection against ischemic injury by nizofenone".
51: 902: 663: 520: 773: 642: 584: 693: 72: 67: 448: 443:. Advances in Experimental Medicine and Biology. Vol. 222. pp. 403โ€“10. 147: 417: 271: 158: 820: 803: 727: 710: 45: 576: 20: 765: 736: 701: 671: 634: 605: 528: 493: 466: 425: 829: 794: 709:
Ochiai C, Asano T, Takakura K, Fukuda T, Horizoe H, Morimoto Y (1982).
133: 28: 384: 294: 285: 203: 802:
Tamura A, Asano T, Sano K, Tsumagari T, Nakajima A (1979).
783:
Archives Internationales de Pharmacodynamie et de Therapie
594:
Archives Internationales de Pharmacodynamie et de Therapie
863: 354: 283: 270: 234: 229: 197: 177: 157: 132: 112: 83: 58: 40: 35: 379:drug which protects neurons from death following 146: 121: 215:DTXSID401014745 DTXSID5048637, DTXSID401014745 883: 8: 482:Cerebrovascular and Brain Metabolism Reviews 317:Clc1ccccc1C(=O)c3cc(()=O)ccc3n2ccnc2CN(CC)CC 19: 890: 876: 549:Annals of the New York Academy of Sciences 217: 166: 27: 819: 726: 186: 396: 334: 314: 213: 104:-imidazol-1-yl}-5-nitrophenyl)methanone 97: 18: 50: 7: 840: 838: 71: 137: 862:. You can help Knowledge (XXG) by 758:10.1111/j.1471-4159.1981.tb04480.x 627:10.1111/j.1471-4159.1985.tb05489.x 569:10.1111/j.1749-6632.1999.tb07871.x 14: 842: 509:European Journal of Pharmacology 255: 252: 246: 342:Key:WZGBZLHGOVJDET-UHFFFAOYSA-N 694:10.1080/01616412.1983.11739654 261: 240: 1: 664:10.1016/0006-2952(84)90684-1 521:10.1016/0014-2999(94)90039-6 449:10.1007/978-1-4615-9510-6_48 441:Oxygen Transport to Tissue X 950: 837: 418:10.3171/jns.1986.64.3.0420 230:Chemical and physical data 934:Nervous system drug stubs 746:Journal of Neurochemistry 615:Journal of Neurochemistry 350: 325: 305: 88: 26: 924:2-Chlorophenyl compounds 909:Nitrobenzene derivatives 854:article relating to the 652:Biochemical Pharmacology 100:(2-chlorophenyl)(2-{2--1 52:International Drug Names 821:10.1161/01.str.10.2.126 728:10.1161/01.str.13.6.788 406:Journal of Neurosurgery 929:Diethylamino compounds 682:Neurological Research 561:1999NYASA.893..430Y 23: 871: 870: 658:(17): 2707โ€“2709. 458:978-1-4615-9512-0 362: 361: 296:Interactive image 199:CompTox Dashboard 16:Chemical compound 941: 892: 885: 878: 846: 839: 833: 823: 798: 777: 740: 730: 705: 675: 646: 609: 588: 533: 532: 515:(1โ€“2): 157โ€“161. 504: 498: 497: 477: 471: 470: 436: 430: 429: 401: 358: 357: 298: 278: 263: 257: 254: 248: 242: 222: 221: 207: 205: 190: 170: 150: 140: 139: 125: 75: 54: 31: 24: 22: 949: 948: 944: 943: 942: 940: 939: 938: 899: 898: 897: 896: 836: 801: 780: 743: 708: 678: 649: 612: 591: 546: 542: 540:Further reading 537: 536: 506: 505: 501: 479: 478: 474: 459: 438: 437: 433: 403: 402: 398: 393: 381:cerebral anoxia 377:neuroprotective 353: 351: 346: 343: 338: 333: 332: 321: 318: 313: 312: 301: 276: 266: 260: 251: 245: 225: 201: 193: 173: 153: 136: 128: 108: 105: 96: 95: 79: 17: 12: 11: 5: 947: 945: 937: 936: 931: 926: 921: 916: 911: 901: 900: 895: 894: 887: 880: 872: 869: 868: 856:nervous system 847: 835: 834: 814:(2): 126โ€“134. 799: 778: 752:(4): 934โ€“938. 741: 721:(6): 788โ€“796. 706: 676: 647: 621:(1): 168โ€“172. 610: 600:(3): 251โ€“260. 589: 555:(1): 430โ€“433. 543: 541: 538: 535: 534: 499: 488:(4): 264โ€“276. 472: 457: 431: 412:(3): 420โ€“426. 395: 394: 392: 389: 360: 359: 348: 347: 345: 344: 341: 339: 336: 328: 327: 326: 323: 322: 320: 319: 316: 308: 307: 306: 303: 302: 300: 299: 291: 289: 281: 280: 274: 268: 267: 264: 258: 249: 243: 238: 232: 231: 227: 226: 224: 223: 210: 208: 195: 194: 192: 191: 183: 181: 175: 174: 172: 171: 163: 161: 155: 154: 152: 151: 143: 141: 130: 129: 127: 126: 118: 116: 110: 109: 107: 106: 99: 91: 90: 89: 86: 85: 81: 80: 78: 77: 64: 62: 56: 55: 48: 38: 37: 33: 32: 15: 13: 10: 9: 6: 4: 3: 2: 946: 935: 932: 930: 927: 925: 922: 920: 917: 915: 912: 910: 907: 906: 904: 893: 888: 886: 881: 879: 874: 873: 867: 865: 861: 857: 853: 848: 845: 841: 831: 827: 822: 817: 813: 809: 805: 800: 796: 792: 788: 784: 779: 775: 771: 767: 763: 759: 755: 751: 747: 742: 738: 734: 729: 724: 720: 716: 712: 707: 703: 699: 695: 691: 687: 683: 677: 673: 669: 665: 661: 657: 653: 648: 644: 640: 636: 632: 628: 624: 620: 616: 611: 607: 603: 599: 595: 590: 586: 582: 578: 574: 570: 566: 562: 558: 554: 550: 545: 544: 539: 530: 526: 522: 518: 514: 510: 503: 500: 495: 491: 487: 483: 476: 473: 468: 464: 460: 454: 450: 446: 442: 435: 432: 427: 423: 419: 415: 411: 407: 400: 397: 390: 388: 386: 382: 378: 374: 370: 366: 356: 349: 340: 335: 331: 324: 315: 311: 304: 297: 293: 292: 290: 287: 282: 275: 273: 269: 239: 237: 233: 228: 220: 216: 212: 211: 209: 200: 196: 189: 185: 184: 182: 180: 176: 169: 165: 164: 162: 160: 156: 149: 145: 144: 142: 135: 131: 124: 120: 119: 117: 115: 111: 103: 98: 94: 87: 82: 74: 69: 66: 65: 63: 61: 57: 53: 49: 47: 43: 39: 36:Clinical data 34: 30: 25: 864:expanding it 849: 811: 807: 789:(1): 77โ€“85. 786: 782: 749: 745: 718: 714: 688:(4): 29โ€“47. 685: 681: 655: 651: 618: 614: 597: 593: 552: 548: 512: 508: 502: 485: 481: 475: 440: 434: 409: 405: 399: 372: 368: 364: 363: 352:   101: 279: gยทmol 84:Identifiers 914:Imidazoles 903:Categories 391:References 373:Midafenone 365:Nizofenone 284:3D model ( 272:Molar mass 188:7A2NOC3R88 159:ChemSpider 123:54533-85-6 114:CAS Number 93:IUPAC name 21:Nizofenone 46:Drugs.com 774:22484255 643:24857145 585:21398803 577:10672283 355:(verify) 60:ATC code 919:Ketones 766:7320731 737:7147293 702:6149485 672:6431991 635:2987409 606:7625881 557:Bibcode 529:7813567 494:8110594 467:3364265 426:3512795 375:) is a 236:Formula 134:PubChem 76:) 70: ( 68:N06BX10 830:442136 828:  808:Stroke 795:543750 793:  772:  764:  735:  715:Stroke 700:  670:  641:  633:  604:  583:  575:  527:  492:  465:  455:  424:  385:stroke 369:Ekonal 310:SMILES 277:412.87 858:is a 850:This 770:S2CID 639:S2CID 581:S2CID 330:InChI 286:JSmol 860:stub 852:drug 826:PMID 791:PMID 762:PMID 733:PMID 698:PMID 668:PMID 631:PMID 602:PMID 573:PMID 525:PMID 490:PMID 463:PMID 453:ISBN 422:PMID 179:UNII 168:4357 148:4514 42:AHFS 816:doi 787:242 754:doi 723:doi 690:doi 660:doi 623:doi 598:328 565:doi 553:893 517:doi 513:262 445:doi 414:doi 204:EPA 138:CID 73:WHO 905:: 824:. 812:10 810:. 806:. 785:. 768:. 760:. 750:37 748:. 731:. 719:13 717:. 713:. 696:. 684:. 666:. 656:33 654:. 637:. 629:. 619:45 617:. 596:. 579:. 571:. 563:. 551:. 523:. 511:. 484:. 461:. 451:. 420:. 410:64 408:. 387:. 371:, 253:Cl 250:21 244:21 891:e 884:t 877:v 866:. 832:. 818:: 797:. 776:. 756:: 739:. 725:: 704:. 692:: 686:5 674:. 662:: 645:. 625:: 608:. 587:. 567:: 559:: 531:. 519:: 496:. 486:5 469:. 447:: 428:. 416:: 367:( 288:) 265:3 262:O 259:4 256:N 247:H 241:C 206:) 202:( 102:H 44:/

Index


AHFS
Drugs.com
International Drug Names
ATC code
N06BX10
WHO
IUPAC name
CAS Number
54533-85-6
PubChem
4514
ChemSpider
4357
UNII
7A2NOC3R88
CompTox Dashboard
DTXSID401014745 DTXSID5048637, DTXSID401014745
Edit this at Wikidata
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
(verify)
neuroprotective
cerebral anoxia
stroke
doi

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.

โ†‘