1324:
264:
Sligar SG, Makris TM, Denisov IG (2005). "Thirty years of microbial P450 monooxygenase research: peroxo-heme intermediates--the central bus station in heme oxygenase catalysis".
1094:
726:
201:(2). Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Pittsburgh School of Medicine: 583–650.
987:
1162:
901:
1365:
1062:
820:
1035:
435:
1074:
1020:
396:
591:
879:
810:
786:
772:
719:
397:"The Medicine Prize Committee unanimously decided that the Wolf Prize in Medicine for 1986 be awarded to Osamu Hayaishi"
1303:
1152:
825:
781:
767:
60:
193:
SW, Ryter; J, Alam (April 2006). "Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications".
894:
576:
1358:
1298:
1259:
1249:
1235:
1231:
1221:
1209:
1189:
1172:
1140:
1104:
1004:
931:
859:
840:
795:
752:
692:
679:
666:
653:
640:
627:
614:
586:
922:
743:
540:
483:
48:
32:
1144:
935:
712:
488:
115:
334:
Mason HS, Fowlks WK, Peterson E (1955). "Oxygen transfer and electron transport by the phenolase complex".
134:"for the discovery of the oxygenase enzymes and elucidation of their structure and biological importance."
1283:
1199:
948:
131:
93:
1394:
1079:
1052:
887:
509:
428:
581:
1351:
1194:
1157:
918:
815:
805:
254:
Hayaishi et al. (1955) Mechanism of the pyrocatechase reaction, J. Am. Chem. Soc. 77 (1955) 5450-5451
1389:
1180:
545:
943:
868:
830:
478:
175:
1089:
977:
378:
316:
281:
210:
167:
150:
Fetzner, Susanne; Steiner, Roberto A. (2010). "Cofactor-independent oxidases and oxygenases".
1335:
1384:
1323:
704:
524:
519:
493:
421:
370:
343:
308:
273:
237:
202:
159:
1067:
571:
555:
468:
75:
1293:
1273:
1268:
910:
735:
609:
550:
127:
44:
241:
59:
Most oxygenases contain either a metal, usually iron, or an organic cofactor, usually
1378:
514:
473:
89:
179:
1112:
1108:
762:
463:
228:
Bugg TDH (2003). "Dioxygenase enzymes: catalytic mechanisms and chemical models".
96:, transfer one oxygen atom to the substrate, and reduce the other oxygen atom to
687:
622:
458:
103:
374:
312:
277:
206:
1244:
849:
163:
1213:
1176:
1120:
661:
635:
382:
320:
285:
214:
171:
130:
from Japan and Howard S. Mason from the US. Hayaishi was awarded the 1986
992:
347:
1288:
106:, or oxygen transferases, incorporate both atoms of molecular oxygen (O
1331:
1130:
1125:
1084:
790:
776:
674:
444:
36:
24:
361:
Waterman MR (2005). "Professor Howard Mason and oxygen activation".
1277:
1012:
970:
963:
958:
953:
648:
97:
28:
126:
Oxygenases were discovered in 1955 simultaneously by two groups,
1057:
1045:
1040:
1030:
1025:
1008:
982:
118:, responsible for breaking down numerous chemicals in the body.
71:
883:
708:
417:
413:
1339:
70:
Oxygenases constitute a major intracellular source of
1258:
1230:
1208:
1171:
1139:
1103:
1003:
930:
858:
839:
751:
600:
564:
533:
502:
451:
43:(as in air) to it. The oxygenases form a class of
1359:
895:
720:
429:
299:Hayaishi O (2005). "An odyssey with oxygen".
114:Among the most common monooxygenases are the
8:
1366:
1352:
902:
888:
880:
727:
713:
705:
436:
422:
414:
67:, leading to its transfer to substrate.
85:Two types of oxygenases are recognized:
142:
152:Applied Microbiology and Biotechnology
110:) into the product(s) of the reaction.
7:
1320:
1318:
1095:24-hydroxycholesterol 7α-hydroxylase
821:4-Hydroxyphenylpyruvate dioxygenase
1338:. You can help Knowledge (XXG) by
63:. These cofactors interact with O
14:
1322:
1075:Cholesterol 7 alpha-hydroxylase
1021:Flavin-containing monooxygenase
1:
811:Homogentisate 1,2-dioxygenase
363:Biochem. Biophys. Res. Commun
301:Biochem. Biophys. Res. Commun
266:Biochem. Biophys. Res. Commun
242:10.1016/S0040-4020(03)00944-X
787:Arachidonate 15-lipoxygenase
773:Arachidonate 12-lipoxygenase
1304:Deoxyhypusine monooxygenase
826:Indoleamine 2,3-dioxygenase
782:Arachidonate 8-lipoxygenase
768:Arachidonate 5-lipoxygenase
1411:
1317:
375:10.1016/j.bbrc.2005.08.120
313:10.1016/j.bbrc.2005.09.019
278:10.1016/j.bbrc.2005.08.094
207:10.1152/physrev.00011.2005
1299:Ecdysone 20-monooxygenase
1250:Stearoyl-CoA desaturase-1
1222:Dopamine beta-hydroxylase
1190:Phenylalanine hydroxylase
796:Linoleate 11-lipoxygenase
592:Michaelis–Menten kinetics
164:10.1007/s00253-010-2455-0
484:Diffusion-limited enzyme
116:cytochrome P450 oxidases
51:is EC 1.13 or EC 1.14.
39:from molecular oxygen O
1334:-related article is a
1284:Squalene monooxygenase
1200:Tryptophan hydroxylase
949:HIF prolyl-hydroxylase
132:Wolf Prize in Medicine
94:mixed function oxidase
1080:Methane monooxygenase
1053:Nitric oxide synthase
755:: two atoms of oxygen
577:Eadie–Hofstee diagram
510:Allosteric regulation
1195:Tyrosine hydroxylase
919:steroid hydroxylases
843:: one atom of oxygen
816:Cysteine dioxygenase
806:Catechol dioxygenase
587:Lineweaver–Burk plot
35:by transferring the
1145:iron–sulfur protein
348:10.1021/ja01615a088
944:Prolyl hydroxylase
869:Inositol oxygenase
850:Firefly luciferase
831:Chlorite dismutase
803:other dioxygenase:
546:Enzyme superfamily
479:Enzyme promiscuity
1347:
1346:
1312:
1311:
978:Lysyl hydroxylase
877:
876:
702:
701:
399:. Wolf Foundation
342:(10): 2914–2915.
236:(36): 7075–7101.
1402:
1368:
1361:
1354:
1326:
1319:
904:
897:
890:
881:
729:
722:
715:
706:
582:Hanes–Woolf plot
525:Enzyme activator
520:Enzyme inhibitor
494:Enzyme catalysis
438:
431:
424:
415:
409:
408:
406:
404:
393:
387:
386:
358:
352:
351:
336:J. Am. Chem. Soc
331:
325:
324:
296:
290:
289:
261:
255:
252:
246:
245:
225:
219:
218:
190:
184:
183:
147:
1410:
1409:
1405:
1404:
1403:
1401:
1400:
1399:
1375:
1374:
1373:
1372:
1315:
1313:
1308:
1262:- miscellaneous
1254:
1226:
1204:
1167:
1135:
1099:
1090:14α-demethylase
999:
926:
911:Oxidoreductases
908:
878:
873:
854:
835:
747:
736:Oxidoreductases
733:
703:
698:
610:Oxidoreductases
596:
572:Enzyme kinetics
560:
556:List of enzymes
529:
498:
469:Catalytic triad
447:
442:
412:
402:
400:
395:
394:
390:
360:
359:
355:
333:
332:
328:
298:
297:
293:
263:
262:
258:
253:
249:
227:
226:
222:
192:
191:
187:
149:
148:
144:
140:
124:
109:
83:
76:carbon monoxide
66:
57:
45:oxidoreductases
42:
17:
12:
11:
5:
1408:
1406:
1398:
1397:
1392:
1387:
1377:
1376:
1371:
1370:
1363:
1356:
1348:
1345:
1344:
1327:
1310:
1309:
1307:
1306:
1301:
1296:
1291:
1286:
1281:
1274:Heme oxygenase
1271:
1269:Cyclooxygenase
1265:
1263:
1256:
1255:
1253:
1252:
1247:
1241:
1239:
1228:
1227:
1225:
1224:
1218:
1216:
1206:
1205:
1203:
1202:
1197:
1192:
1186:
1184:
1169:
1168:
1166:
1165:
1160:
1155:
1149:
1147:
1137:
1136:
1134:
1133:
1128:
1123:
1117:
1115:
1101:
1100:
1098:
1097:
1092:
1087:
1082:
1077:
1072:
1071:
1070:
1065:
1060:
1050:
1049:
1048:
1043:
1038:
1033:
1028:
1017:
1015:
1001:
1000:
998:
997:
996:
995:
990:
980:
975:
974:
973:
968:
967:
966:
961:
956:
940:
938:
936:2-oxoglutarate
928:
927:
909:
907:
906:
899:
892:
884:
875:
874:
872:
871:
865:
863:
856:
855:
853:
852:
846:
844:
837:
836:
834:
833:
828:
823:
818:
813:
808:
799:
798:
793:
784:
779:
770:
758:
756:
749:
748:
740:monooxygenases
734:
732:
731:
724:
717:
709:
700:
699:
697:
696:
683:
670:
657:
644:
631:
618:
604:
602:
598:
597:
595:
594:
589:
584:
579:
574:
568:
566:
562:
561:
559:
558:
553:
548:
543:
537:
535:
534:Classification
531:
530:
528:
527:
522:
517:
512:
506:
504:
500:
499:
497:
496:
491:
486:
481:
476:
471:
466:
461:
455:
453:
449:
448:
443:
441:
440:
433:
426:
418:
411:
410:
388:
353:
326:
291:
256:
247:
220:
185:
158:(3): 791–804.
141:
139:
136:
128:Osamu Hayaishi
123:
120:
112:
111:
107:
101:
90:Monooxygenases
82:
79:
64:
56:
53:
40:
15:
13:
10:
9:
6:
4:
3:
2:
1407:
1396:
1393:
1391:
1388:
1386:
1383:
1382:
1380:
1369:
1364:
1362:
1357:
1355:
1350:
1349:
1343:
1341:
1337:
1333:
1328:
1325:
1321:
1316:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1287:
1285:
1282:
1279:
1275:
1272:
1270:
1267:
1266:
1264:
1261:
1257:
1251:
1248:
1246:
1243:
1242:
1240:
1237:
1233:
1229:
1223:
1220:
1219:
1217:
1215:
1211:
1207:
1201:
1198:
1196:
1193:
1191:
1188:
1187:
1185:
1182:
1181:BH4 dependent
1178:
1174:
1170:
1164:
1161:
1159:
1156:
1154:
1151:
1150:
1148:
1146:
1142:
1138:
1132:
1129:
1127:
1124:
1122:
1119:
1118:
1116:
1114:
1110:
1106:
1102:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1069:
1066:
1064:
1061:
1059:
1056:
1055:
1054:
1051:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1023:
1022:
1019:
1018:
1016:
1014:
1010:
1006:
1002:
994:
991:
989:
986:
985:
984:
981:
979:
976:
972:
969:
965:
962:
960:
957:
955:
952:
951:
950:
947:
946:
945:
942:
941:
939:
937:
933:
929:
924:
920:
916:
912:
905:
900:
898:
893:
891:
886:
885:
882:
870:
867:
866:
864:
861:
857:
851:
848:
847:
845:
842:
838:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
801:
800:
797:
794:
792:
788:
785:
783:
780:
778:
774:
771:
769:
766:
764:
760:
759:
757:
754:
750:
745:
741:
737:
730:
725:
723:
718:
716:
711:
710:
707:
694:
690:
689:
684:
681:
677:
676:
671:
668:
664:
663:
658:
655:
651:
650:
645:
642:
638:
637:
632:
629:
625:
624:
619:
616:
612:
611:
606:
605:
603:
599:
593:
590:
588:
585:
583:
580:
578:
575:
573:
570:
569:
567:
563:
557:
554:
552:
551:Enzyme family
549:
547:
544:
542:
539:
538:
536:
532:
526:
523:
521:
518:
516:
515:Cooperativity
513:
511:
508:
507:
505:
501:
495:
492:
490:
487:
485:
482:
480:
477:
475:
474:Oxyanion hole
472:
470:
467:
465:
462:
460:
457:
456:
454:
450:
446:
439:
434:
432:
427:
425:
420:
419:
416:
398:
392:
389:
384:
380:
376:
372:
368:
364:
357:
354:
349:
345:
341:
337:
330:
327:
322:
318:
314:
310:
306:
302:
295:
292:
287:
283:
279:
275:
272:(1): 346–54.
271:
267:
260:
257:
251:
248:
243:
239:
235:
231:
224:
221:
216:
212:
208:
204:
200:
196:
189:
186:
181:
177:
173:
169:
165:
161:
157:
153:
146:
143:
137:
135:
133:
129:
121:
119:
117:
105:
102:
99:
95:
91:
88:
87:
86:
80:
78:
77:
73:
68:
62:
54:
52:
50:
46:
38:
34:
30:
26:
22:
1395:Enzyme stubs
1340:expanding it
1329:
1314:
1113:flavoprotein
917:, including
915:dioxygenases
914:
802:
763:lipoxygenase
761:
739:
688:Translocases
685:
672:
659:
646:
633:
623:Transferases
620:
607:
464:Binding site
401:. Retrieved
391:
366:
362:
356:
339:
335:
329:
304:
300:
294:
269:
265:
259:
250:
233:
229:
223:
198:
194:
188:
155:
151:
145:
125:
113:
104:Dioxygenases
84:
69:
58:
20:
18:
459:Active site
369:(1): 7–11.
230:Tetrahedron
195:Physiol Rev
1390:Oxygenases
1379:Categories
1245:Tyrosinase
1212:: reduced
1175:: reduced
1143:: reduced
1107:: reduced
662:Isomerases
636:Hydrolases
503:Regulation
307:(1): 2–6.
138:References
1214:ascorbate
1177:pteridine
541:EC number
81:Mechanism
55:Structure
49:EC number
33:substrate
21:oxygenase
565:Kinetics
489:Cofactor
452:Activity
383:16153596
321:16185652
286:16139790
215:16601269
180:25377247
172:20157809
47:; their
29:oxidizes
1385:Enzymes
1260:1.14.99
1238:: other
1232:1.14.18
1210:1.14.17
1173:1.14.16
1141:1.14.15
1105:1.14.14
1005:1.14.13
932:1.14.11
862:: other
860:1.13.99
841:1.13.12
753:1.13.11
675:Ligases
445:Enzymes
403:May 12,
122:History
23:is any
1332:enzyme
1109:flavin
988:ALKBH1
791:ALOX15
777:ALOX12
649:Lyases
381:
319:
284:
213:
178:
170:
61:flavin
37:oxygen
25:enzyme
16:Enzyme
1330:This
1278:HMOX1
1013:NADPH
971:P4HTM
964:EGLN3
959:EGLN2
954:EGLN1
925:1.14)
746:1.13)
601:Types
176:S2CID
98:water
92:, or
27:that
1336:stub
1294:21A2
1289:17A1
1163:11A1
1158:11B2
1153:11B1
1121:19A1
1068:NOS3
1063:NOS2
1058:NOS1
1046:FMO5
1041:FMO4
1036:FMO3
1031:FMO2
1026:FMO1
1009:NADH
983:AlkB
693:list
686:EC7
680:list
673:EC6
667:list
660:EC5
654:list
647:EC4
641:list
634:EC3
628:list
621:EC2
615:list
608:EC1
405:2014
379:PMID
317:PMID
282:PMID
211:PMID
168:PMID
74:and
72:iron
1131:2E1
1126:2D6
1111:or
1085:3A4
1011:or
993:FTO
371:doi
367:338
344:doi
309:doi
305:338
274:doi
270:338
238:doi
203:doi
160:doi
19:An
1381::
1236:19
1007::
934::
923:EC
913::
744:EC
738::
377:.
365:.
340:77
338:.
315:.
303:.
280:.
268:.
234:59
232:.
209:.
199:86
197:.
174:.
166:.
156:86
154:.
31:a
1367:e
1360:t
1353:v
1342:.
1280:)
1276:(
1234:-
1183:)
1179:(
921:(
903:e
896:t
889:v
789:/
775:/
765::
742:(
728:e
721:t
714:v
695:)
691:(
682:)
678:(
669:)
665:(
656:)
652:(
643:)
639:(
630:)
626:(
617:)
613:(
437:e
430:t
423:v
407:.
385:.
373::
350:.
346::
323:.
311::
288:.
276::
244:.
240::
217:.
205::
182:.
162::
108:2
100:.
65:2
41:2
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