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Olfactory system

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498:. In contrast, recent finding suggested the molecular aspects of olfactory dysfunction can be recognized as a hallmark of amyloidogenesis-related diseases and there may even be a causal link through the disruption of multivalent metal ion transport and storage. Doctors can detect damage to the olfactory system by presenting the patient with odors via a scratch and sniff card or by having the patient close their eyes and try to identify commonly available odors like coffee or peppermint candy. Doctors must exclude other diseases that inhibit or eliminate 'the sense of smell' such as chronic colds or sinusitus before making the diagnosis that there is permanent damage to the olfactory system. 136: 214: 397:
odor sensory neuron can be excited by multiple odor components. It has been proposed that, in an olfactory environment typically composed of multiple odor components (e.g., odor of a dog entering a kitchen that contains a background coffee odor), feedback from the olfactory cortex to the olfactory bulb suppresses the pre-existing odor background (e.g., coffee) via olfactory adaptation, so that the newly arrived foreground odor (e.g., dog) can be singled out from the mixture for recognition.
342:, and olfactory system. In total it has 27 inputs and 20 outputs. An oversimplification of its role is to state that it: checks to ensure odor signals arose from actual odors rather than villi irritation, regulates motor behavior (primarily social and stereotypical) brought on by odors, integrates auditory and olfactory sensory info to complete the aforementioned tasks, and plays a role in transmitting positive signals to reward sensors (and is thus involved in addiction). 40: 511: 401: 541:
chronic smelling problems. This increases greatly between people of ages 65 and 80 with about half experiencing significant problems smelling. Then for adults over 80, the numbers rise to almost 75%. The basis for age-related changes in smell function include closure of the cribriform plate, and cumulative damage to the olfactory receptors from repeated viral and other insults throughout life.
276: 199:) or through the throat when the tongue pushes air to the back of the nasal cavity while chewing or swallowing (retro-nasal olfaction). Inside the nasal cavity, mucus lining the walls of the cavity dissolves odor molecules. Mucus also covers the olfactory epithelium, which contains mucous membranes that produce and store mucus, and olfactory glands that secrete 2615: 284:
cells are different with mitral having low firing-rates and being easily inhibited by neighboring cells, while tufted have high rates of firing and are more difficult to inhibit. How the bulbar neural circuit transforms odor inputs to the bulb to the bulbar responses that are sent to the olfactory cortex can be partly understood by a mathematical model.
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on examination. Prevalence rose from 4.2% at age 40–49 to 39.4% at 80 years and older and was higher in men than women, in blacks and Mexican Americans than in whites and in less than more educated. Of concern for safety, 20% of persons aged 70 and older were unable to identify smoke and 31%, natural gas.
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Trauma-related olfactory dysfunction depends on the severity of the trauma and whether strong acceleration/deceleration of the head occurred. Occipital and side impact causes more damage to the olfactory system than frontal impact. However, recent evidence from individuals with traumatic brain injury
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Prevalence of olfactory dysfunction in the general US population was assessed by questionnaire and examination in a national health survey in 2012–2014. Among over a thousand persons aged 40 years and older, 12.0% reported a problem with smell in the past 12 months and 12.4% had olfactory dysfunction
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is a rare condition typified by an abnormally heightened sense of smell. Like vision and hearing, the olfactory problems can be bilateral or unilateral meaning if a person has anosmia on the right side of the nose but not the left, it is a unilateral right anosmia. On the other hand, if it is on both
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When different odor objects or components are mixed, humans and other mammals sniffing the mixture (presented by, e.g., a sniff bottle) are often unable to identify the components in the mixture even though they can recognize each individual component presented alone. This is largely because each
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The main olfactory bulb transmits pulses to both mitral and tufted cells, which help determine odor concentration based on the time certain neuron clusters fire (called 'timing code'). These cells also note differences between highly similar odors and use that data to aid in later recognition. The
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Neurodegenerative diseases with well-established genetic determinants are also associated with olfactory dysfunction. Such dysfunction, for example, is found in patients with familial Parkinson's disease and those with Down syndrome. Further studies have concluded that the olfactory loss may be
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Age is the strongest reason for olfactory decline in healthy adults, having even greater impact than does cigarette smoking. Age-related changes in smell function often go unnoticed and smell ability is rarely tested clinically unlike hearing and vision. 2% of people under 65 years of age have
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Neurologists have observed that olfactory dysfunction is a cardinal feature of several neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Most of these patients are unaware of an olfactory deficit until after testing where 85% to 90% of early-stage patients showed
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Huntington's disease is also associated with problems in odor identification, detection, discrimination, and memory. The problem is prevalent once the phenotypic elements of the disorder appear, although it is unknown how far in advance the olfactory loss precedes the phenotypic expression.
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Other neurodegenerative diseases that affect olfactory dysfunction include Huntington's disease, multi-infarct dementia, amyotrophic lateral sclerosis, and schizophrenia. These diseases have more moderate effects on the olfactory system than Alzheimer's or Parkinson's diseases. Furthermore,
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The orbitofrontal cortex (OFC) is heavily correlated with the cingulate gyrus and septal area to act out positive/negative reinforcement. The OFC is the expectation of reward/punishment in response to stimuli. The OFC represents the emotion and reward in decision making.
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progressive supranuclear palsy and parkinsonism are associated with only minor olfactory problems. These findings have led to the suggestion that olfactory testing may help in the diagnosis of several different neurodegenerative diseases.
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The hippocampus (although minimally connected to the main olfactory bulb) receives almost all of its olfactory information via the amygdala (either directly or via the BNST). The hippocampus forms new and reinforces existing memories.
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evolution this processing is secondary and therefore is largely unnoticed in human interactions. Allomones include flower scents, natural herbicides, and natural toxic plant chemicals. The info for these processes comes from the
601:, and heavy metals (cadmium, chromium, nickel, and manganese), can alter the ability to smell. These agents not only damage the olfactory epithelium, but they are likely to enter the brain via the olfactory mucosa. 2475:
Doty, R. L.; Golbe, L. I.; McKeown, D. A.; Stern, M. B.; Lehrach, C. M.; Crawford, D. (1 May 1993). "Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson's disease".
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Tjalve, H.; Henriksson, J.; Tallkvist, J.; Larsson, B. S.; Lindquist, N. G. (1996). "Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats".
1686:"The organization of centrifugal projections from the anterior olfactory nucleus, ventral hippocampal rudiment, and piriform cortex to the main olfactory bulb in the hamster: An autoradiographic study" 2142:
Doty, Richard L.; Shaman, Paul; Dann, Michael (March 1984). "Development of the university of pennsylvania smell identification test: A standardized microencapsulated test of olfactory function".
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Olfactory nerves and fibers transmit information about odors from the peripheral olfactory system to the central olfactory system of the brain, which is separated from the epithelium by the
1963:"Olfactory object recognition, segmentation, adaptation, target seeking, and discrimination by the network of the olfactory bulb and cortex: computational model and experimental data" 549:
The most common cause of permanent hyposmia and anosmia are upper respiratory infections. Such dysfunctions show no change over time and can sometimes reflect damage not only to the
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The anterior olfactory nucleus distributes reciprocal signals between the olfactory bulb and piriform cortex. The anterior olfactory nucleus is the memory hub for smell.
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This diagram linearly (unless otherwise mentioned) tracks the projections of all known structures that allow for olfaction to their relevant endpoints in the human brain.
1521:"Projections from bed nuclei of the stria terminalis, posterior division: Implications for cerebral hemisphere regulation of defensive and reproductive behaviors" 379:
Mitral pulses to the hypothalamus promote/discourage feeding, whereas accessory olfactory bulb pulses regulate reproductive and odor-related-reflex processes.
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Igarashi, K. M.; Ieki, N.; An, M.; Yamaguchi, Y.; Nagayama, S.; Kobayakawa, K.; Kobayakawa, R.; Tanifuji, M.; Sakano, H.; Chen, W. R.; Mori, K. (2012-06-06).
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indirectly via the olfactory bulb. The main olfactory bulb's pulses in the amygdala are used to pair odors to names and recognize odor to odor differences.
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The common causes of olfactory dysfunction: advanced age, viral infections, exposure to toxic chemicals, head trauma, and neurodegenerative diseases.
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Similarly, the parahippocampus encodes, recognizes and contextualizes scenes. The parahippocampal gyrus houses the topographical map for olfaction.
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Mori, Kensaku, ed. (2014), "Odor and Pheromone Molecules, Receptors, and Behavioral Responses: Odorant Dynamics and Kinetics (Chapter 2.5.2)",
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Doty, R. L.; Yousem, D. M.; Pham, L. T.; Kreshak, A. A.; Geckle, R.; Lee, W. W. (1997). "Olfactory dysfunction in patients with head trauma".
647: 1419:"Projections from the amygdaloid complex and adjacent olfactory structures to the entorhinal cortex and to the subiculum in the rat and cat" 716: 4011: 553:, but also to the central olfactory structures as a result of viral invasions into the brain. Among these virus-related disorders are the 1575: 259:. Olfactory nerve fibers, which originate in the epithelium, pass through the cribriform plate, connecting the epithelium to the brain's 372:, specifically bed nuclei (BNST), act as the information pathway between the amygdala and hypothalamus, as well as the hypothalamus and 224:
in the epithelium detect odor molecules dissolved in the mucus and transmit information about the odor to the brain in a process called
357:(same-species, cross-species, and cross-species where the emitter is harmed and the sensor is benefited, respectively) signals. Due to 376:. BNST abnormalities often lead to sexual confusion and immaturity. BNST also connects to the septal area, rewarding sexual behavior. 2950: 824:"Topographic organization of tufted cell axonal projections in the hamster main olfactory bulb: An intrabulbar associational system" 1591: 3429: 1095:"Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex" 2058:
Mahmoudi, Morteza; Suslick, Kenneth S. (2012). "Protein fibrillation and the olfactory system: speculations on their linkage".
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This article is about the olfactory system in vertebrates, particularly humans. For the sense of smell in other lifeforms, see
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Olfactory problems can be divided into different types based on their malfunction. The olfactory dysfunction can be total (
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is associated with olfactory disturbance. Most viral infections are unrecognizable because they are so mild or entirely
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system, because they both give the brain information about the chemical composition of objects through a process called
879:"Parallel Mitral and Tufted Cell Pathways Route Distinct Odor Information to Different Targets in the Olfactory Cortex" 4144: 195:
Odor molecules can enter the peripheral pathway and reach the nasal cavity either through the nostrils when inhaling (
2619: 2436:"Olfactory Testing as an Aid in the Diagnosis of Parkinson's Disease: Development of Optimal Discrimination Criteria" 4098: 3434: 2901: 2732: 221: 181: 109: 3907: 1258:"Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium" 4190: 3849: 3016: 2715: 2633: 124: 112:. The main olfactory system detects airborne substances, while the accessory system senses fluid-phase stimuli. 3854: 3688: 2765: 3834: 3210: 2875: 2773: 812:, p. 182, "The Study of Humans Uncovers Novel Aspects in Brain Organization of Olfaction (Chapter 9.2)" 213: 3998: 3829: 3439: 3225: 3044: 2931: 2893: 2727: 659: 566: 491: 487: 479: 417: 97: 67: 1795: 4036: 3026: 3006: 2815: 2803: 2793: 312: 108:
directly associated with specific organs. Most mammals and reptiles have a main olfactory system and an
1352:"Emotion, olfaction, and the human amygdala: Amygdala activation during aversive olfactory stimulation" 1962: 455:. An inability to recognize odors despite a normally functioning olfactory system is termed olfactory 3897: 3864: 3563: 3278: 3182: 2670: 2335: 1363: 947: 550: 413: 300: 225: 185: 161: 2519:
CHEN, M; LANDER, T; MURPHY, C (May 2006). "Nasal health in Down syndrome: A cross-sectional study".
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suggests that smell loss can occur with changes in brain function outside of olfactory cortex.
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associated with intellectual disability, rather than any Alzheimer's disease-like pathology.
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O'Doherty, J.; Kringelbach, M. L.; Rolls, E. T.; Hornak, J.; Andrews, C. (January 2001).
471:) results in anosmia on the same side as the destruction. Also, irritative lesion of the 2339: 1520: 1367: 951: 4114: 3965: 3652: 3632: 3358: 3309: 3245: 3193: 3149: 3011: 2722: 2656: 2411: 2386: 2358: 2323: 2265: 2209: 2186: 2119: 2094: 1883: 1850: 1233: 1208: 1119: 1094: 1015: 990: 911: 878: 570: 525: 405: 237: 2588: 2563: 1489: 1110: 4184: 4134: 4129: 4083: 4021: 4006: 3902: 3624: 3568: 3383: 3350: 3334: 3253: 3197: 3157: 3106: 3097: 3054: 2562:
McKeown, D A; Doty, R L; Perl, D P; Frye, R E; Simms, I; Mester, A (1 October 1996).
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that bind to odor molecules, causing an electrical response that spreads through the
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Doty, RL; Hastings, L. (2001). "Neurotoxic exposure and olfactory impairment".
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that line the nasal cavity). The primary components of the layers of
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The Olfactory System: From Odor Molecules to Motivational Behaviors
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sides of the nose it is called bilateral anosmia or total anosmia.
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The olfactory tubercle connects to numerous areas of the amygdala,
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Action potential propagated by olfactory stimuli in an axon.
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decreased activity in central odor processing structures.
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Destruction to olfactory bulb, tract, and primary cortex (
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The Journal of Steroid Biochemistry and Molecular Biology
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The peripheral olfactory system consists mainly of the
1851:"Cortical Feedback Control of Olfactory Bulb Circuits" 1796:"The capacity of humans to identify odors in mixtures" 1207:
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Journal of Neurology, Neurosurgery & Psychiatry
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Journal of Neurology, Neurosurgery & Psychiatry
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These conditions can cause 3946:Olfactory reference syndrome 3723:Alice in Wonderland syndrome 2533:10.1016/j.otohns.2005.12.035 2156:10.1016/0031-9384(84)90269-5 1979:10.1016/j.cobeha.2016.03.009 1867:10.1016/j.neuron.2012.10.020 1812:10.1016/0031-9384(89)90041-3 1321:10.1126/science.286.5440.716 1274:10.1016/0960-0760(91)90255-4 960:10.1126/science.291.5505.889 447:, or microsmia), distorted ( 4145:Sensory processing disorder 3315:Gustation (taste or flavor) 3305:Equilibrioception (balance) 1961:Zhaoping, Li (2016-10-01). 585:Exposure to toxic chemicals 279:Details of olfaction system 4207: 4099:Supernumerary phantom limb 3435:Infrared sensing in snakes 3295:Visual perception (vision) 2902:Anterior olfactory nucleus 2349:10.1038/s41598-021-83621-2 614:Neurodegenerative diseases 432:Loss of smell is known as 110:accessory olfactory system 18: 3850:Microwave auditory effect 3017:Transduction (physiology) 2763: 2144:Physiology & Behavior 2111:10.1007/s11154-016-9364-1 1800:Physiology & Behavior 995:The Journal of Physiology 228:. Olfactory neurons have 222:Olfactory sensory neurons 66: 37: 3855:Music-specific disorders 3211:Vestibulocochlear (VIII) 2766:Primary olfactory cortex 2234:Clin Occupat Environ Med 2193:. bjaa041 (7): 609–622. 422:Olfactory receptor cells 232:(tiny hairs) containing 3835:Auditory verbal agnosia 3689:Juxtacapillary receptor 2876:Medial forebrain bundle 2774:Lateral olfactory stria 2757:areas involved in smell 2099:Rev Endocr Metab Disord 2060:Trends in Biotechnology 1305:"The Vomeronasal Organ" 883:Journal of Neuroscience 3830:Auditory hallucination 3440:Surface wave detection 3045:Multimodal integration 2932:Evolution of olfaction 2894:Medial olfactory stria 2453:10.1006/neur.1995.0011 2200:10.1093/chemse/bjaa041 2036:10.1055/s-0028-1124025 1912:Biological Cybernetics 1478:Brain Research Reviews 1377:10.1073/pnas.94.8.4119 1099:Brain Research Reviews 1044:Biological Cybernetics 660:Olfactic communication 567:influenza-like illness 529: 480:traumatic brain injury 424: 280: 242:olfactory nerve fibers 218: 140: 68:Anatomical terminology 4089:Phantom limb syndrome 4037:Tactile hallucination 3226:Glossopharyngeal (IX) 3027:Active sensory system 2816:Periamygdaloid cortex 2804:Hippocampal formation 2794:EC-hippocampus system 2580:10.1136/jnnp.61.4.412 2185:Parma V (June 2020). 2023:Seminars in Neurology 1906:Li, Z. (1990-02-01). 1757:10.1002/cne.901610105 1702:10.1002/cne.902030310 1435:10.1002/cne.901720409 1160:10.1002/cne.901910204 840:10.1002/cne.902350408 513: 428:Clinical significance 403: 313:parahippocampal gyrus 278: 216: 138: 3898:Labyrinthine fistula 3865:Spatial hearing loss 3564:Campaniform sensilla 3279:Somatosensory cortex 2622:at Wikimedia Commons 2490:10.1212/WNL.43.5.962 2403:10.1136/jnnp.50.1.88 551:olfactory epithelium 301:orbitofrontal cortex 226:sensory transduction 203:found in the mucus. 162:olfactory epithelium 23:. For machines, see 3684:Nociceptin receptor 3554:Merkel nerve ending 3539:Mechanotransduction 2340:2021NatSR..11.4043P 1635:Nature Neuroscience 1368:1997PNAS...94.4119Z 952:2001Sci...291..889F 492:Alzheimer's disease 488:Parkinson's disease 295:which includes the 244:at the back of the 234:olfactory receptors 4046:Nociception (pain) 3638:Olfactory receptor 3590:Photoreceptor cell 3544:Lamellar corpuscle 3468:Photomorphogenesis 3330:nociception (pain) 3022:Sensory processing 2711:Olfactory receptor 2688:Sustentacular cell 2328:Scientific Reports 1924:10.1007/BF00201449 1056:10.1007/BF00200803 721:Psych.Stanford.edu 693:Sinauer Associates 530: 425: 309:olfactory tubercle 281: 219: 141: 4178: 4177: 4163:Biases and errors 4158: 4157: 4094:Somatoparaphrenia 4063:Pain dissociation 3908:Ménière's disease 3840:Cortical deafness 3718:Visual impairment 3697: 3696: 3559:Bulbous corpuscle 3549:Tactile corpuscle 3517:sensory receptors 3509: 3508: 3392: 3391: 3345: 3344: 3310:Olfaction (smell) 3264:Vestibular cortex 3246:Cerebral cortices 3083: 3082: 3070:Motion perception 2940: 2939: 2910: 2909: 2888: 2887: 2799:Entorhinal cortex 2745:Olfactory trigone 2618:Media related to 2440:Neurodegeneration 1537:10.1002/cne.20002 1315:(5440): 716–720. 946:(5505): 889–894. 889:(23): 7970–7985. 727:on 9 October 2016 414:Nasal epithelium 364:vomeronasal organ 201:metabolic enzymes 182:olfactory neurons 170:epithelial tissue 82: 81: 77: 25:Machine olfaction 4198: 4191:Olfactory system 3825:Auditory agnosia 3757:Optic neuropathy 3706: 3574:Stretch receptor 3522: 3420:Magnetoreception 3415:Electroreception 3403: 3325:mechanoreception 3274:Gustatory cortex 3269:Olfactory cortex 3103: 3094: 3012:Sensory receptor 2995: 2967: 2960: 2953: 2944: 2927:Olfactory system 2856:Stria terminalis 2836:Habenular nuclei 2832:Stria medullaris 2811:Prepyriform area 2779: 2761: 2650: 2643: 2636: 2627: 2620:Olfactory system 2617: 2602: 2601: 2591: 2559: 2553: 2552: 2516: 2510: 2509: 2472: 2466: 2465: 2455: 2431: 2425: 2424: 2414: 2378: 2372: 2371: 2361: 2351: 2319: 2313: 2312: 2295:(9): 1131–1140. 2284: 2278: 2277: 2248: 2242: 2241: 2229: 2223: 2222: 2212: 2202: 2182: 2176: 2175: 2139: 2133: 2132: 2122: 2090: 2084: 2083: 2055: 2049: 2048: 2038: 2014: 1999: 1998: 1958: 1952: 1951: 1903: 1897: 1896: 1886: 1861:(6): 1161–1174. 1846: 1840: 1839: 1791: 1785: 1784: 1736: 1730: 1729: 1681: 1675: 1674: 1626: 1620: 1619: 1571: 1565: 1564: 1516: 1510: 1509: 1484:(1–2): 192–246. 1469: 1463: 1462: 1414: 1408: 1407: 1397: 1379: 1362:(8): 4119–4124. 1347: 1341: 1340: 1300: 1294: 1293: 1253: 1247: 1246: 1236: 1204: 1198: 1197: 1171: 1139: 1133: 1132: 1122: 1090: 1084: 1083: 1035: 1029: 1028: 1018: 986: 980: 979: 931: 925: 924: 914: 874: 868: 867: 819: 813: 807: 801: 800: 799: 797: 780: 774: 773: 772: 770: 757: 751: 750: 742: 736: 735: 734: 732: 723:, archived from 712: 703: 702: 701: 699: 680: 545:Viral infections 469:brodmann area 34 370:Stria terminalis 293:olfactory cortex 253:cribriform plate 190:olfactory nerves 178:olfactory glands 174:mucous membranes 117:gustatory system 86:olfactory system 74:edit on Wikidata 42: 33:Olfactory system 30: 4206: 4205: 4201: 4200: 4199: 4197: 4196: 4195: 4181: 4180: 4179: 4174: 4154: 4103: 4072: 4041: 3993: 3960: 3912: 3874: 3806: 3797:Stereoblindness 3738:Color blindness 3693: 3670: 3647: 3619: 3578: 3526:Mechanoreceptor 3515: 3505: 3501:Machine hearing 3496:Computer vision 3491:Robotic sensing 3477: 3454: 3388: 3341: 3283: 3259:Auditory cortex 3240: 3187: 3150:Sensory systems 3144: 3079: 3031: 2989: 2987: 2980: 2971: 2941: 2936: 2906: 2884: 2864: 2840: 2820: 2789:Piriform cortex 2768: 2749: 2740:Olfactory tract 2703:Olfactory nerve 2697: 2659: 2654: 2610: 2605: 2561: 2560: 2556: 2518: 2517: 2513: 2474: 2473: 2469: 2433: 2432: 2428: 2380: 2379: 2375: 2321: 2320: 2316: 2286: 2285: 2281: 2250: 2249: 2245: 2231: 2230: 2226: 2191:Chemical Senses 2184: 2183: 2179: 2141: 2140: 2136: 2092: 2091: 2087: 2066:(12): 609–610. 2057: 2056: 2052: 2016: 2015: 2002: 1960: 1959: 1955: 1905: 1904: 1900: 1848: 1847: 1843: 1793: 1792: 1788: 1738: 1737: 1733: 1683: 1682: 1678: 1628: 1627: 1623: 1573: 1572: 1568: 1518: 1517: 1513: 1471: 1470: 1466: 1416: 1415: 1411: 1349: 1348: 1344: 1302: 1301: 1297: 1255: 1254: 1250: 1206: 1205: 1201: 1141: 1140: 1136: 1092: 1091: 1087: 1037: 1036: 1032: 988: 987: 983: 933: 932: 928: 876: 875: 871: 821: 820: 816: 808: 804: 795: 793: 782: 781: 777: 768: 766: 759: 758: 754: 744: 743: 739: 730: 728: 714: 713: 706: 697: 695: 682: 681: 677: 673: 656: 637: 616: 607: 587: 547: 538: 526:Olfactory bulbs 508: 430: 374:pituitary gland 340:auditory cortex 297:piriform cortex 273: 265:olfactory bulbs 209: 146: 133: 78: 45: 28: 17: 12: 11: 5: 4204: 4202: 4194: 4193: 4183: 4182: 4176: 4175: 4173: 4172: 4166: 4164: 4160: 4159: 4156: 4155: 4153: 4152: 4147: 4142: 4137: 4132: 4127: 4122: 4117: 4111: 4109: 4105: 4104: 4102: 4101: 4096: 4091: 4086: 4080: 4078: 4077:Proprioception 4074: 4073: 4071: 4070: 4065: 4060: 4055: 4049: 4047: 4043: 4042: 4040: 4039: 4034: 4029: 4024: 4019: 4014: 4009: 4003: 4001: 3995: 3994: 3992: 3991: 3986: 3981: 3976: 3970: 3968: 3962: 3961: 3959: 3958: 3953: 3948: 3943: 3938: 3933: 3928: 3922: 3920: 3914: 3913: 3911: 3910: 3905: 3900: 3895: 3890: 3884: 3882: 3876: 3875: 3873: 3872: 3867: 3862: 3857: 3852: 3847: 3842: 3837: 3832: 3827: 3822: 3816: 3814: 3808: 3807: 3805: 3804: 3799: 3794: 3789: 3784: 3779: 3774: 3769: 3764: 3759: 3754: 3745: 3740: 3735: 3730: 3725: 3720: 3714: 3712: 3703: 3699: 3698: 3695: 3694: 3692: 3691: 3686: 3680: 3678: 3672: 3671: 3669: 3668: 3663: 3657: 3655: 3653:Thermoreceptor 3649: 3648: 3646: 3645: 3640: 3635: 3633:Taste receptor 3629: 3627: 3621: 3620: 3618: 3617: 3612: 3607: 3602: 3597: 3592: 3586: 3584: 3580: 3579: 3577: 3576: 3571: 3566: 3561: 3556: 3551: 3546: 3541: 3536: 3530: 3528: 3519: 3511: 3510: 3507: 3506: 3504: 3503: 3498: 3493: 3487: 3485: 3479: 3478: 3476: 3475: 3470: 3464: 3462: 3456: 3455: 3453: 3452: 3447: 3442: 3437: 3432: 3427: 3422: 3417: 3411: 3409: 3400: 3394: 3393: 3390: 3389: 3387: 3386: 3381: 3376: 3371: 3366: 3361: 3359:Proprioception 3355: 3353: 3347: 3346: 3343: 3342: 3340: 3339: 3338: 3337: 3332: 3327: 3317: 3312: 3307: 3302: 3297: 3291: 3289: 3285: 3284: 3282: 3281: 3276: 3271: 3266: 3261: 3256: 3250: 3248: 3242: 3241: 3239: 3238: 3233: 3231:Trigeminal (V) 3228: 3223: 3218: 3213: 3208: 3202: 3200: 3189: 3188: 3186: 3185: 3180: 3175: 3170: 3165: 3160: 3154: 3152: 3146: 3145: 3143: 3142: 3137: 3132: 3127: 3122: 3117: 3111: 3109: 3107:Sensory organs 3100: 3091: 3085: 3084: 3081: 3080: 3078: 3077: 3072: 3067: 3062: 3057: 3052: 3047: 3041: 3039: 3033: 3032: 3030: 3029: 3024: 3019: 3014: 3009: 3003: 3001: 2992: 2982: 2981: 2972: 2970: 2969: 2962: 2955: 2947: 2938: 2937: 2935: 2934: 2929: 2924: 2918: 2916: 2912: 2911: 2908: 2907: 2905: 2904: 2898: 2896: 2890: 2889: 2886: 2885: 2883: 2882: 2872: 2870: 2866: 2865: 2863: 2862: 2848: 2846: 2842: 2841: 2839: 2838: 2828: 2826: 2822: 2821: 2819: 2818: 2813: 2808: 2807: 2806: 2801: 2791: 2785: 2783: 2776: 2770: 2769: 2764: 2758: 2751: 2750: 2748: 2747: 2742: 2737: 2736: 2735: 2730: 2723:Olfactory bulb 2720: 2719: 2718: 2707: 2705: 2699: 2698: 2696: 2695: 2690: 2685: 2684: 2683: 2678: 2667: 2665: 2661: 2660: 2655: 2653: 2652: 2645: 2638: 2630: 2624: 2623: 2609: 2608:External links 2606: 2604: 2603: 2574:(4): 412–414. 2554: 2527:(5): 741–745. 2511: 2484:(5): 962–965. 2467: 2426: 2373: 2314: 2279: 2260:(6): 347–356. 2243: 2224: 2177: 2150:(3): 489–502. 2134: 2105:(2): 221–240. 2085: 2050: 2029:(1): 074–081. 2000: 1953: 1918:(4): 349–361. 1898: 1841: 1806:(5): 809–814. 1786: 1731: 1696:(3): 475–493. 1676: 1621: 1586:(6): 608–619. 1566: 1531:(4): 396–433. 1511: 1464: 1429:(4): 723–752. 1409: 1342: 1295: 1268:(4): 573–582. 1248: 1219:(3): 655–668. 1199: 1154:(2): 193–212. 1134: 1085: 1050:(5): 379–392. 1030: 1001:(1): 101–117. 981: 926: 869: 834:(4): 503–518. 814: 802: 775: 752: 737: 704: 674: 672: 669: 668: 667: 662: 655: 652: 636: 633: 615: 612: 606: 603: 586: 583: 546: 543: 537: 534: 507: 504: 429: 426: 406:Olfactory bulb 272: 269: 238:sensory neuron 208: 205: 145: 142: 132: 129: 106:special senses 98:sensory system 80: 79: 70: 64: 63: 58: 52: 51: 47: 46: 43: 35: 34: 15: 13: 10: 9: 6: 4: 3: 2: 4203: 4192: 4189: 4188: 4186: 4171: 4168: 4167: 4165: 4161: 4151: 4148: 4146: 4143: 4141: 4138: 4136: 4135:Hallucination 4133: 4131: 4130:Derealization 4128: 4126: 4123: 4121: 4118: 4116: 4113: 4112: 4110: 4106: 4100: 4097: 4095: 4092: 4090: 4087: 4085: 4084:Asomatognosia 4082: 4081: 4079: 4075: 4069: 4066: 4064: 4061: 4059: 4056: 4054: 4051: 4050: 4048: 4044: 4038: 4035: 4033: 4030: 4028: 4025: 4023: 4022:Hyperesthesia 4020: 4018: 4015: 4013: 4010: 4008: 4007:Astereognosis 4005: 4004: 4002: 4000: 3996: 3990: 3987: 3985: 3982: 3980: 3977: 3975: 3972: 3971: 3969: 3967: 3963: 3957: 3954: 3952: 3949: 3947: 3944: 3942: 3939: 3937: 3934: 3932: 3929: 3927: 3924: 3923: 3921: 3919: 3915: 3909: 3906: 3904: 3903:Labyrinthitis 3901: 3899: 3896: 3894: 3891: 3889: 3886: 3885: 3883: 3881: 3877: 3871: 3868: 3866: 3863: 3861: 3858: 3856: 3853: 3851: 3848: 3846: 3843: 3841: 3838: 3836: 3833: 3831: 3828: 3826: 3823: 3821: 3818: 3817: 3815: 3813: 3809: 3803: 3800: 3798: 3795: 3793: 3790: 3788: 3785: 3783: 3780: 3778: 3775: 3773: 3770: 3768: 3765: 3763: 3760: 3758: 3755: 3753: 3749: 3746: 3744: 3741: 3739: 3736: 3734: 3731: 3729: 3726: 3724: 3721: 3719: 3716: 3715: 3713: 3711: 3707: 3704: 3700: 3690: 3687: 3685: 3682: 3681: 3679: 3677: 3673: 3667: 3664: 3662: 3659: 3658: 3656: 3654: 3650: 3644: 3641: 3639: 3636: 3634: 3631: 3630: 3628: 3626: 3625:Chemoreceptor 3622: 3616: 3613: 3611: 3608: 3606: 3603: 3601: 3598: 3596: 3593: 3591: 3588: 3587: 3585: 3583:Photoreceptor 3581: 3575: 3572: 3570: 3569:Slit sensilla 3567: 3565: 3562: 3560: 3557: 3555: 3552: 3550: 3547: 3545: 3542: 3540: 3537: 3535: 3532: 3531: 3529: 3527: 3523: 3520: 3518: 3512: 3502: 3499: 3497: 3494: 3492: 3489: 3488: 3486: 3484: 3480: 3474: 3471: 3469: 3466: 3465: 3463: 3461: 3457: 3451: 3448: 3446: 3443: 3441: 3438: 3436: 3433: 3431: 3428: 3426: 3423: 3421: 3418: 3416: 3413: 3412: 3410: 3408: 3404: 3401: 3399: 3395: 3385: 3384:Visceral pain 3382: 3380: 3377: 3375: 3372: 3370: 3367: 3365: 3362: 3360: 3357: 3356: 3354: 3352: 3348: 3336: 3335:thermoception 3333: 3331: 3328: 3326: 3323: 3322: 3321: 3318: 3316: 3313: 3311: 3308: 3306: 3303: 3301: 3298: 3296: 3293: 3292: 3290: 3286: 3280: 3277: 3275: 3272: 3270: 3267: 3265: 3262: 3260: 3257: 3255: 3254:Visual cortex 3252: 3251: 3249: 3247: 3243: 3237: 3234: 3232: 3229: 3227: 3224: 3222: 3219: 3217: 3216:Olfactory (I) 3214: 3212: 3209: 3207: 3204: 3203: 3201: 3199: 3198:spinal nerves 3195: 3190: 3184: 3181: 3179: 3176: 3174: 3171: 3169: 3166: 3164: 3161: 3159: 3156: 3155: 3153: 3151: 3147: 3141: 3138: 3136: 3133: 3131: 3128: 3126: 3123: 3121: 3118: 3116: 3113: 3112: 3110: 3108: 3104: 3101: 3099: 3095: 3092: 3090: 3086: 3076: 3073: 3071: 3068: 3066: 3063: 3061: 3058: 3056: 3055:Consciousness 3053: 3051: 3048: 3046: 3043: 3042: 3040: 3038: 3034: 3028: 3025: 3023: 3020: 3018: 3015: 3013: 3010: 3008: 3005: 3004: 3002: 3000: 2996: 2993: 2991: 2983: 2979: 2975: 2968: 2963: 2961: 2956: 2954: 2949: 2948: 2945: 2933: 2930: 2928: 2925: 2923: 2920: 2919: 2917: 2913: 2903: 2900: 2899: 2897: 2895: 2891: 2881: 2877: 2874: 2873: 2871: 2867: 2861: 2857: 2853: 2850: 2849: 2847: 2843: 2837: 2833: 2830: 2829: 2827: 2823: 2817: 2814: 2812: 2809: 2805: 2802: 2800: 2797: 2796: 2795: 2792: 2790: 2787: 2786: 2784: 2780: 2777: 2775: 2771: 2767: 2762: 2759: 2756: 2752: 2746: 2743: 2741: 2738: 2734: 2731: 2729: 2726: 2725: 2724: 2721: 2717: 2714: 2713: 2712: 2709: 2708: 2706: 2704: 2700: 2694: 2691: 2689: 2686: 2682: 2679: 2677: 2674: 2673: 2672: 2669: 2668: 2666: 2662: 2658: 2651: 2646: 2644: 2639: 2637: 2632: 2631: 2628: 2621: 2616: 2612: 2611: 2607: 2599: 2595: 2590: 2585: 2581: 2577: 2573: 2569: 2565: 2558: 2555: 2550: 2546: 2542: 2538: 2534: 2530: 2526: 2522: 2515: 2512: 2507: 2503: 2499: 2495: 2491: 2487: 2483: 2479: 2471: 2468: 2463: 2459: 2454: 2449: 2445: 2441: 2437: 2430: 2427: 2422: 2418: 2413: 2408: 2404: 2400: 2396: 2392: 2388: 2384: 2377: 2374: 2369: 2365: 2360: 2355: 2350: 2345: 2341: 2337: 2333: 2329: 2325: 2318: 2315: 2310: 2306: 2302: 2298: 2294: 2290: 2283: 2280: 2275: 2271: 2267: 2263: 2259: 2255: 2247: 2244: 2239: 2235: 2228: 2225: 2220: 2216: 2211: 2206: 2201: 2196: 2192: 2188: 2181: 2178: 2173: 2169: 2165: 2161: 2157: 2153: 2149: 2145: 2138: 2135: 2130: 2126: 2121: 2116: 2112: 2108: 2104: 2100: 2096: 2089: 2086: 2081: 2077: 2073: 2069: 2065: 2061: 2054: 2051: 2046: 2042: 2037: 2032: 2028: 2024: 2020: 2013: 2011: 2009: 2007: 2005: 2001: 1996: 1992: 1988: 1984: 1980: 1976: 1972: 1968: 1964: 1957: 1954: 1949: 1945: 1941: 1937: 1933: 1929: 1925: 1921: 1917: 1913: 1909: 1902: 1899: 1894: 1890: 1885: 1880: 1876: 1872: 1868: 1864: 1860: 1856: 1852: 1845: 1842: 1837: 1833: 1829: 1825: 1821: 1817: 1813: 1809: 1805: 1801: 1797: 1790: 1787: 1782: 1778: 1774: 1770: 1766: 1762: 1758: 1754: 1750: 1746: 1742: 1735: 1732: 1727: 1723: 1719: 1715: 1711: 1707: 1703: 1699: 1695: 1691: 1687: 1680: 1677: 1672: 1668: 1664: 1660: 1656: 1652: 1648: 1647:10.1038/82959 1644: 1641:(1): 95–102. 1640: 1636: 1632: 1625: 1622: 1617: 1613: 1609: 1605: 1601: 1597: 1593: 1589: 1585: 1581: 1577: 1570: 1567: 1562: 1558: 1554: 1550: 1546: 1542: 1538: 1534: 1530: 1526: 1522: 1515: 1512: 1507: 1503: 1499: 1495: 1491: 1487: 1483: 1479: 1475: 1468: 1465: 1460: 1456: 1452: 1448: 1444: 1440: 1436: 1432: 1428: 1424: 1420: 1413: 1410: 1405: 1401: 1396: 1391: 1387: 1383: 1378: 1373: 1369: 1365: 1361: 1357: 1353: 1346: 1343: 1338: 1334: 1330: 1326: 1322: 1318: 1314: 1310: 1306: 1299: 1296: 1291: 1287: 1283: 1279: 1275: 1271: 1267: 1263: 1259: 1252: 1249: 1244: 1240: 1235: 1230: 1226: 1222: 1218: 1214: 1210: 1203: 1200: 1195: 1191: 1187: 1183: 1179: 1175: 1170: 1169:2027.42/50010 1165: 1161: 1157: 1153: 1149: 1145: 1138: 1135: 1130: 1126: 1121: 1116: 1112: 1108: 1104: 1100: 1096: 1089: 1086: 1081: 1077: 1073: 1069: 1065: 1061: 1057: 1053: 1049: 1045: 1041: 1034: 1031: 1026: 1022: 1017: 1012: 1008: 1004: 1000: 996: 992: 985: 982: 977: 973: 969: 965: 961: 957: 953: 949: 945: 941: 937: 930: 927: 922: 918: 913: 908: 904: 900: 896: 892: 888: 884: 880: 873: 870: 865: 861: 857: 853: 849: 845: 841: 837: 833: 829: 825: 818: 815: 811: 806: 803: 792: 791: 790:Medical Daily 786: 779: 776: 765: 764: 756: 753: 748: 741: 738: 726: 722: 718: 711: 709: 705: 694: 690: 686: 679: 676: 670: 666: 663: 661: 658: 657: 653: 651: 649: 646:won the 2004 645: 641: 640:Linda B. 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Index

Olfaction
Machine olfaction

FMA
7190
Anatomical terminology
edit on Wikidata
sense
smell
sensory system
olfaction
special senses
accessory olfactory system
gustatory system
chemosensory
transduction

nostrils
ethmoid bone
nasal cavity
olfactory epithelium
mucus
epithelial tissue
mucous membranes
olfactory glands
olfactory neurons
nerve fibers
olfactory nerves
olfaction
metabolic enzymes

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