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Three Aurora kinases have been identified in mammalian cells to date. Besides being implicated as mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated expression profiles in many human cancers. The human Aurora kinases present
304:
Tsuchiya Y, Byrne DP, Burgess SG, Bormann J, Bakovic J, Huang Y, Zhyvoloup A, Yu BY, Peak Chew S, Tran T, Bellany F, Tabor AB, Chan AE, Guruprasad L, Garifulin O, Filonenko V, Vonderach M, Ferries S, Eyers CE, Carroll J, Skehel M, Bayliss R, Eyers PA, Gout I (Sep 2019).
100:(the microtubule organising centres in eukaryotic cells). Aurora A activity is positively-regulated by the spindle protein TPX2, and has recently been shown to be a target for thiol-containing molecules, such as
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Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. Journal of Cell
Science 112 (1999) 3591–3601.
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domain containing 15–20 residues. The N-terminal domain of three proteins share low sequence conservation, which determines selectivity during
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Bolanos-Garcia V M. Aurora kinases. The
International Journal of Biochemistry & Cell Biology 37 (2005) 1572–1577.
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to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling
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As described above, there are three classes of aurora kinases in multicellular organisms, including humans:
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domain of 39–129 residues in length, a related Ser/Thr protein kinase domain and a short
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110:(a.k.a. Aurora 1) functions in the attachment of the mitotic spindle to the centromere.
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265:"Structural basis of Aurora-A activation by TPX2 at the mitotic spindle"
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307:"Covalent Aurora A regulation by the metabolic integrator coenzyme A"
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3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
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122:) works in germ-line cells and little is known about its function.
224:"A novel mechanism for activation of the protein kinase Aurora A"
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and is required for correct duplication and separation of the
2221:
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166:"Roles of Aurora Kinases in Mitosis and Tumorigenesis"
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263:
Bayliss R, Sardon T, Vernos I, Conti E (April 2003).
222:
Eyers PA, Erikson E, Chen LG, Eyers PA (April 2003).
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39:segregation. Defects in this segregation can cause
150:
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47:. The first aurora kinases were identified in
43:, a condition which is highly associated with
2575:
2237:
432:Non-specific serine/threonine protein kinases
381:
8:
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2222:
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2146:
1536:
1522:
815:Goodpasture-antigen-binding protein kinase
427:
413:
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374:
366:
1528:Serine/threonine-specific protein kinases
702:(isocitrate dehydrogenase (NADP+)) kinase
419:Serine/threonine-specific protein kinases
401:Serine/threonine-specific protein kinases
358:at the U.S. National Library of Medicine
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318:
280:
239:
31:that help the dividing cell dispense its
2063:Receptor protein serine/threonine kinase
2519:
2046:Low-density-lipoprotein receptor kinase
144:
61:a similar domain organization, with a
791:Fas-activated serine/threonine kinase
7:
2540:
2538:
2072:Bone morphogenetic protein receptors
606:Dephospho-(reductase kinase) kinase
88:(a.k.a. Aurora 2) functions during
2554:. You can help Knowledge (XXG) by
1061:G-protein coupled receptor kinases
14:
1051:Beta adrenergic receptor kinase-2
736:(tyrosine 3-monooxygenase) kinase
2522:
1743:Mitogen-activated protein kinase
2129:Anti-MĂĽllerian hormone receptor
2012:(acetyl-CoA carboxylase) kinase
1684:(RNA-polymerase)-subunit kinase
1046:Beta adrenergic receptor kinase
1037:Beta adrenergic receptor kinase
1752:Extracellular signal-regulated
27:. They are phosphotransferase
1:
1816:P38 mitogen-activated protein
915:cGMP-dependent protein kinase
876:cAMP-dependent protein kinase
572:Pyruvate dehydrogenase kinase
518:Ataxia telangiectasia mutated
282:10.1016/s1097-2765(03)00392-7
241:10.1016/s0960-9822(03)00166-0
185:10.1158/1541-7786.MCR-06-0208
615:AMP-activated protein kinase
164:Fu, Jingyan (January 2007).
71:protein–protein interactions
1530:(EC 2.7.11.21-EC 2.7.11.30)
320:10.1016/j.redox.2019.101318
2622:
2537:
1457:Elongation factor 2 kinase
421:(EC 2.7.11.1-EC 2.7.11.20)
2400:Michaelis–Menten kinetics
2159:
2145:
1852:MAP kinase kinase kinases
1535:
1521:
1384:Myosin light-chain kinase
1090:Ca2+/calmodulin-dependent
755:Myosin-heavy-chain kinase
426:
412:
173:Molecular Cancer Research
2292:Diffusion-limited enzyme
2152:Dual-specificity kinases
360:Medical Subject Headings
21:serine/threonine kinases
1575:Cyclin-dependent kinase
50:Drosophila melanogaster
23:that are essential for
2550:-related article is a
2385:Eadie–Hofstee diagram
2318:Allosteric regulation
2395:Lineweaver–Burk plot
1418:Phosphorylase kinase
41:genetic instability
2354:Enzyme superfamily
2287:Enzyme promiscuity
2029:Tropomyosin kinase
1983:Tau-protein kinase
25:cell proliferation
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998:Protein kinase N1
953:Protein kinase Cζ
33:genetic materials
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2527:
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2518:
2390:Hanes–Woolf plot
2333:Enzyme activator
2328:Enzyme inhibitor
2302:Enzyme catalysis
2246:
2239:
2232:
2223:
2161:
2147:
1794:C-Jun N-terminal
1537:
1523:
1027:Rhodopsin kinase
1018:Rhodopsin kinase
948:Protein kinase C
939:Protein kinase C
924:Protein kinase G
885:Protein kinase A
496:Protein kinase B
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133:Aurora inhibitor
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2418:Oxidoreductases
2404:
2380:Enzyme kinetics
2368:
2364:List of enzymes
2337:
2306:
2277:Catalytic triad
2255:
2250:
2220:
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2155:
2133:
2057:
2040:
2023:
2006:
1977:
1837:
1737:
1708:P70-S6 Kinase 1
1678:
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1451:
1412:
1378:
1084:
1055:
1031:
1012:
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779:Aurora C kinase
774:Aurora B kinase
769:Aurora A kinase
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228:Current Biology
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2342:Classification
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2066:
2065:(EC 2.7.11.30)
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2049:
2048:(EC 2.7.11.29)
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2041:
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2038:
2034:
2032:
2031:(EC 2.7.11.28)
2025:
2024:
2022:
2021:
2017:
2015:
2014:(EC 2.7.11.27)
2008:
2007:
2005:
2004:
1999:
1994:
1988:
1986:
1985:(EC 2.7.11.26)
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1978:
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1845:(EC 2.7.11.25)
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1745:(EC 2.7.11.24)
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1686:(EC 2.7.11.23)
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1577:(EC 2.7.11.22)
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1543:(EC 2.7.11.21)
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1483:(EC 2.7.11.21)
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1459:(EC 2.7.11.20)
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1420:(EC 2.7.11.19)
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1387:
1386:(EC 2.7.11.18)
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1092:(EC 2.7.11.17)
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1063:(EC 2.7.11.16)
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1039:(EC 2.7.11.15)
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1020:(EC 2.7.11.14)
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941:(EC 2.7.11.13)
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917:(EC 2.7.11.12)
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878:(EC 2.7.11.11)
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835:
834:(EC 2.7.11.10)
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350:External links
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275:(8): 691–697.
269:Molecular Cell
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234:(8): 691–697.
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17:Aurora kinases
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2:
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2359:Enzyme family
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2355:
2352:
2350:
2347:
2346:
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2334:
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2329:
2326:
2324:
2323:Cooperativity
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2313:
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2303:
2300:
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2282:Oxyanion hole
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1190:
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1162:
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1097:
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1038:
1034:
1028:
1025:
1024:
1022:
1019:
1015:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
989:
986:
984:
981:
979:
976:
974:
971:
969:
966:
964:
961:
959:
956:
954:
951:
949:
946:
945:
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936:
930:
927:
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922:
921:
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916:
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903:
901:
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893:
891:
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886:
883:
882:
880:
877:
873:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
838:
836:
833:
829:
822:
821:
819:
817:(EC 2.7.11.9)
816:
812:
806:
803:
801:
798:
797:
795:
793:(EC 2.7.11.8)
792:
788:
780:
777:
775:
772:
770:
767:
766:
765:
764:Aurora kinase
762:
761:
759:
757:(EC 2.7.11.7)
756:
752:
746:
743:
742:
740:
738:(EC 2.7.11.6)
737:
733:
727:
724:
722:
719:
717:
714:
712:
709:
708:
706:
704:(EC 2.7.11.5)
703:
699:
693:
690:
688:
685:
683:
680:
679:
677:
675:(EC 2.7.11.4)
674:
670:
662:
659:
657:
654:
652:
649:
648:
646:
642:
639:
637:
634:
633:
631:
627:
624:
622:
619:
618:
616:
613:
612:
610:
608:(EC 2.7.11.3)
607:
603:
597:
594:
592:
589:
587:
584:
582:
579:
578:
576:
574:(EC 2.7.11.2)
573:
569:
561:
558:
557:
556:
553:
549:
546:
544:
541:
539:
536:
534:
531:
530:
529:
528:EIF-2 kinases
526:
524:
521:
519:
516:
512:
509:
507:
504:
502:
499:
498:
497:
494:
492:
489:
487:
484:
482:
479:
477:
474:
472:
469:
467:
464:
462:
459:
457:
454:
452:
449:
447:
444:
442:
439:
438:
436:
434:(EC 2.7.11.1)
433:
429:
425:
420:
415:
411:
406:
402:
398:
391:
386:
384:
379:
377:
372:
371:
368:
361:
357:
356:aurora+kinase
354:
353:
349:
340:
336:
331:
326:
321:
316:
312:
311:Redox Biology
308:
300:
297:
292:
288:
283:
278:
274:
270:
266:
259:
256:
251:
247:
242:
237:
233:
229:
225:
218:
215:
209:
206:
194:
190:
186:
182:
178:
174:
167:
160:
157:
151:
149:
145:
138:
134:
131:
130:
126:
121:
120:
115:
112:
109:
106:
103:
99:
95:
91:
87:
84:
83:
82:
76:
74:
72:
68:
64:
58:
56:
52:
51:
46:
45:tumorigenesis
42:
38:
34:
30:
26:
22:
18:
2606:EC 2.7 stubs
2556:expanding it
2542:
2534:
2496:Translocases
2493:
2480:
2467:
2454:
2441:
2431:Transferases
2428:
2415:
2272:Binding site
1703:P70S6 kinase
763:
310:
299:
272:
268:
258:
231:
227:
217:
208:
196:. Retrieved
176:
172:
159:
117:
80:
59:
48:
16:
15:
2267:Active site
2154:(EC 2.7.12)
1541:Polo kinase
1481:Polo kinase
98:centrosomes
2595:Categories
2470:Isomerases
2444:Hydrolases
2311:Regulation
832:IÎşB kinase
407:2.7.11-12)
198:7 February
139:References
102:Coenzyme A
67:C-terminal
63:N-terminal
2601:EC 2.7.11
2349:EC number
958:PKC alpha
37:chromatid
2373:Kinetics
2297:Cofactor
2260:Activity
1314:KIAA0999
1209:MAPKAPK5
1204:MAPKAPK3
1199:MAPKAPK2
339:31546169
291:14580337
250:12699628
193:17259342
179:(1): 1.
127:See also
114:Aurora C
108:Aurora B
90:prophase
86:Aurora A
2529:Biology
2483:Ligases
2253:Enzymes
1973:MAP3K14
1951:MAP3K11
1946:MAP3K10
1936:MAP3K13
1931:MAP3K12
1733:RPS6KC1
1728:RPS6KA1
1723:RPS6KA3
1718:RPS6KA2
1713:RPS6KB2
1698:RPS6KA4
1693:RPS6KA5
1344:Kalirin
1309:SNF1LK2
548:EIF2AK4
543:EIF2AK3
397:Kinases
330:6812009
94:mitosis
77:Classes
29:enzymes
2548:enzyme
2545:EC 2.7
2515:Portal
2457:Lyases
2203:MAP2K7
2198:MAP2K6
2193:MAP2K5
2188:MAP2K4
2183:MAP2K3
2178:MAP2K2
2173:MAP2K1
2124:ACVRL1
2119:ACVR2B
2114:ACVR2A
2109:ACVR1C
2104:ACVR1B
2087:BMPR1B
2082:BMPR1A
1956:MAP3K7
1941:MAP3K9
1892:MAP3K8
1887:MAP3K7
1882:MAP3K6
1877:MAP3K5
1872:MAP3K4
1867:MAP3K3
1862:MAP3K2
1857:MAP3K1
1831:MAPK14
1826:MAPK13
1821:MAPK11
1809:MAPK10
1787:MAPK15
1782:MAPK12
1674:CDC2L1
1649:CDC2L5
1324:SNF1LK
1149:CAMK2G
1144:CAMK2D
1139:CAMK2B
1134:CAMK2A
1124:CAMK1G
1119:CAMK1D
1114:CAMK1B
1109:CAMK1A
963:PRKCB1
900:PRKACA
895:PRKACB
890:PRKACG
866:IKBKAP
692:BCKDHB
687:BCKDHA
661:PRKAG3
656:PRKAG2
651:PRKAG1
641:PRKAB2
636:PRKAB1
626:PRKAA2
621:PRKAA1
466:STK38L
362:(MeSH)
337:
327:
289:
248:
191:
55:aurora
2543:This
2409:Types
2165:MAP2K
2099:ACVR1
2092:BMPR2
2077:BMPR1
2002:GSK-3
1843:MAP3K
1804:MAPK9
1799:MAPK8
1777:MAPK7
1772:MAPK6
1767:MAPK4
1762:MAPK3
1757:MAPK1
1669:PFTK1
1664:PCTK3
1659:PCTK2
1654:PCTK1
1644:CDK12
1639:CDK10
1614:CDKL5
1594:CDKL2
1471:STK19
1466:EEF2K
1447:PHKG2
1442:PHKG1
1432:PHKA2
1427:PHKA1
1408:MYLK4
1403:MYLK3
1398:MYLK2
1374:DCLK1
1369:Titin
1359:TRIB3
1354:TRIB2
1349:TRIB1
1339:TSSK2
1319:STK40
1304:PSKH1
1299:PRKD3
1294:PRKD2
1274:PHKG2
1269:PHKG1
1259:OBSCN
1254:NUAK2
1249:NUAK1
1244:MKNK2
1239:MKNK1
1229:MARK4
1224:MARK3
1219:MARK2
1214:MARK1
1194:STK11
1189:DAPK3
1184:DAPK2
1179:DAPK1
1174:CHEK2
1169:CHEK1
1154:CAMK4
1129:CAMK2
1104:CAMK1
1099:BRSK2
993:PRKCQ
988:PRKCI
983:PRKCG
978:PRKCH
973:PRKCE
968:PRKCD
929:PRKG1
861:IKBKG
856:IKBKE
805:STK10
800:FASTK
726:IDH3G
721:IDH3B
716:IDH3A
682:BCKDK
476:ROCK1
461:STK38
456:MAST2
451:MAST1
446:LATS2
441:LATS1
169:(PDF)
119:AURKC
2552:stub
2501:list
2494:EC7
2488:list
2481:EC6
2475:list
2468:EC5
2462:list
2455:EC4
2449:list
2442:EC3
2436:list
2429:EC2
2423:list
2416:EC1
1992:TPK1
1968:CDC7
1926:MLKs
1919:KSR2
1914:KSR1
1909:BRAF
1904:ARAF
1899:RAFs
1634:CDK9
1629:CDK8
1624:CDK7
1619:CDK6
1609:CDK5
1604:CDK4
1599:CDK3
1589:CDK2
1584:CDK1
1565:PLK4
1560:PLK3
1555:PLK2
1550:PLK1
1505:PLK4
1500:PLK3
1495:PLK2
1490:PLK1
1437:PHKB
1393:MYLK
1364:TRIO
1334:SPEG
1329:SNRK
1289:PKD1
1284:PIM2
1279:PIM1
1264:PASK
1234:MELK
1164:CASK
1159:MLCK
1080:GRK6
1075:GRK5
1070:GRK4
1008:PKN3
1003:PKN2
905:PRKY
851:TBK1
846:IKK2
841:CHUK
745:STK4
711:IDH2
596:PDK4
591:PDK3
586:PDK2
581:PDK1
560:WEE1
555:Wee1
523:mTOR
511:AKT3
506:AKT2
501:AKT1
491:SGK3
486:SGK2
335:PMID
287:PMID
246:PMID
200:2022
189:PMID
19:are
1997:TTK
1961:ZAK
538:HRI
533:PKR
481:SGK
471:CIT
325:PMC
315:doi
277:doi
236:doi
181:doi
92:of
2597::
647:Îł
632:β
617:α
405:EC
399::
333:.
323:.
313:.
309:.
285:.
273:13
271:.
267:.
244:.
232:13
230:.
226:.
187:.
175:.
171:.
147:^
104:.
73:.
57:.
2583:e
2576:t
2569:v
2558:.
2517::
2503:)
2499:(
2490:)
2486:(
2477:)
2473:(
2464:)
2460:(
2451:)
2447:(
2438:)
2434:(
2425:)
2421:(
2245:e
2238:t
2231:v
2054:-
2037:-
2020:-
823:-
403:(
389:e
382:t
375:v
341:.
317::
293:.
279::
252:.
238::
202:.
183::
177:5
116:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.