171:
73:
1287:
333:
378:(1863 – 1949), a German pathologist, first described in 1926. A third subtype, PAS III, has been described in adults, but apart from the absence of adrenal failure, no clinical differences between types II and III have been described. Because of this, both of these subtypes are generally referred to as PAS II.
249:
45:
1193:
1178:
987:
Macchia, Donatella et al. "President John F Kennedy's medical history: coeliac disease and autoimmune polyglandular syndrome type 2." Postgraduate medical journal vol. 96,1139 (2020): 543-549. doi:10.1136/postgradmedj-2020-137722
1333:
834:
1453:
1326:
307:
will only render (or identify) those genes which place the individual at higher risk. Other methods/exam to ascertain if an individual has autoimmune polyendocrine syndrome type 2 are:
1319:
1932:
1446:
668:"Autoimmune Adrenal Insufficiency and Autoimmune Polyendocrine Syndromes: Autoantibodies, Autoantigens, and Their Applicability in Diagnosis and Disease Prediction"
127:
also known as APS-II, or PAS II, is the most common form of the polyglandular failure syndromes. PAS II is defined as the association between autoimmune
1439:
1094:
818:
2010:
1611:
1359:
17:
796:
1966:
1788:
1122:
857:
484:
1391:
575:
1386:
1381:
1208:
2005:
1783:
1354:
1132:
1104:
867:
828:
406:
124:
433:
167:
Signs and symptoms that are consistent in an individual affected with autoimmune polyendocrine syndrome type 2 are the following:
1642:
1778:
1044:"Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS-2)"
1824:
1686:
1681:
1420:
1904:
765:
2057:
1961:
1376:
2052:
1863:
1666:
360:
1894:
1572:
434:"Autoimmune polyglandular syndrome type 2 | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program"
170:
1924:
1747:
1838:
1607:
1593:
1219:
136:
1711:
1474:
1302:
265:
144:
723:
1842:
1270:
788:
217:
2000:
1995:
1979:
1889:
1819:
1676:
1588:
375:
128:
72:
2022:
1197:
2062:
2027:
1909:
1899:
1793:
1691:
1671:
1508:
1466:
1371:
1081:
261:
209:
198:
81:
1719:
1311:
567:
222:
1729:
1724:
1524:
1513:
1230:
1128:
1100:
1073:
1065:
1020:
970:
962:
921:
913:
863:
824:
757:
697:
689:
648:
621:
613:
542:
524:
480:
237:
101:
61:
1773:
1707:
1624:
1619:
1560:
1487:
1462:
1055:
1015:
1010:
998:
952:
903:
679:
639:
Betterle C, Zanchetta R (April 2003). "Update on autoimmune polyendocrine syndromes (APS)".
605:
568:"Type II Polyglandular Autoimmune Syndrome Clinical Presentation: History, Physical, Causes"
532:
516:
1431:
1914:
1884:
1768:
1696:
1550:
1503:
1403:
1343:
476:
469:
388:
355:
296:
132:
287:
reacting to specific antigens is common, in the immune system of an affected individual.
1292:
441:
1798:
1752:
1545:
537:
504:
284:
204:
1202:
2046:
1973:
1565:
1085:
1060:
1043:
666:
Betterle, Corrado; Dal Pra, Chiara; Mantero, Franco; Zanchetta, Renato (2002-06-01).
520:
401:
347:
268:
involved in this condition are HLA-DQ2(DR3 (DQB*0201)) and HLA-DQ8(DR4 (DQB1*0302)),
66:
260:
In terms of genetics one finds that autoimmune polyendocrine syndrome type 2 has an
1868:
1658:
1540:
1529:
1259:
232:
190:
343:
Management of autoimmune polyendocrine syndrome type 2 consists of the following:
1224:
1555:
1535:
1519:
280:
91:
44:
1235:
716:"OMIM Entry - % 269200 - AUTOIMMUNE POLYENDOCRINE SYNDROME, TYPE II; APS2"
1187:
745:
609:
391:
is presumed to have suffered from
Autoimmune Polyendocrine Syndrome, Type II.
321:
1069:
966:
917:
693:
617:
596:
Kahaly, George J. (2012-12-01). "Polyglandular
Autoimmune Syndrome Type II".
528:
1413:
1408:
1254:
892:"Polyglandular Autoimmune Syndromes: Immunogenetics and Long-Term Follow-Up"
185:
1077:
1024:
999:"Endocrine and Autoimmune Aspects of the Health History of John F. Kennedy"
974:
925:
908:
891:
761:
701:
684:
667:
652:
625:
546:
1398:
1265:
1170:
957:
940:
264:
pattern of inheritance, with an incomplete penetrance. Furthermore, the
143:. Rather, individuals are at a higher risk when they carry a particular
1478:
311:
227:
156:
152:
148:
1155:
332:
1847:
1182:
179:
248:
1814:
1482:
505:"Autoimmune polyglandular syndrome Type 2: the tip of an iceberg?"
247:
169:
1213:
715:
140:
1435:
1315:
316:
272:, which indicates this is a multifactorial disorder, as well.
139:, or both. It is heterogeneous and has not been linked to one
503:
Betterle, C; Lazzarotto, F; Presotto, F (19 April 2017).
896:
The
Journal of Clinical Endocrinology & Metabolism
862:. Springer Science & Business Media. p. 143.
279:
affected organs show chronic inflammatory infiltrate (
159:). APS-II affects women to a greater degree than men.
96:
Human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4)
1160:
859:
Immunoendocrinology: Scientific and
Clinical Aspects
365:
Dietary guidelines(depending if diabetic/Addison d.)
1988:
1954:
1945:
1923:
1877:
1856:
1837:
1807:
1761:
1746:
1705:
1657:
1650:
1636:
1606:
1581:
1496:
1473:
1245:
1164:
110:
100:
90:
80:
60:
32:
27:
890:Kahaly, George J.; Dittmar, Manuela (2003-07-01).
468:
1093:Wass, John A. H.; Stewart, Paul M. (2011-07-28).
467:Greenspan, Francis S.; Gardner, David C. (2004).
1933:Transfusion-associated graft-versus-host disease
1042:Michels, A. W.; Eisenbarth, G. S. (2009-05-01).
789:"What are complex or multifactorial disorders?"
1447:
1327:
1096:Oxford Textbook of Endocrinology and Diabetes
8:
746:"Autoimmune polyglandular syndrome, type II"
462:
460:
458:
1951:
1853:
1758:
1654:
1633:
1493:
1454:
1440:
1432:
1334:
1320:
1312:
1161:
283:), this would be an indication. Moreover,
71:
43:
24:
1059:
1014:
956:
907:
683:
536:
1303:Autoimmune polyendocrine syndrome type 2
820:Genetic Diagnosis of Endocrine Disorders
817:Weiss, Roy E.; Refetoff, Samuel (2016).
331:
121:Autoimmune polyendocrine syndrome type 2
56:genotypes responsible for this condition
28:Autoimmune polyendocrine syndrome type 2
18:Autoimmune polyendocrine syndrome type 1
1967:Allergic bronchopulmonary aspergillosis
1016:10.7326/0003-4819-151-5-200909010-00011
744:Majeroni, BA; Patel, P (1 March 2007).
418:
562:
560:
558:
556:
428:
426:
424:
422:
1789:Post-streptococcal glomerulonephritis
498:
496:
7:
941:"Polyglandular autoimmune syndromes"
837:from the original on 14 January 2023
509:Clinical and Experimental Immunology
768:from the original on 14 April 2017
475:. New York: McGraw-Hill. pp.
14:
2006:Autoimmune polyendocrine syndrome
1355:Autoimmune polyendocrine syndrome
945:European Journal of Endocrinology
407:Autoimmune polyendocrine syndrome
125:autoimmune polyendocrine syndrome
1643:Hemolytic disease of the newborn
1285:
1061:10.1111/j.1365-2796.2009.02091.x
939:Kahaly, George J. (2009-07-01).
521:10.1111/j.1365-2249.2004.02561.x
374:The condition was recognized by
1825:Subacute bacterial endocarditis
1687:Immune thrombocytopenic purpura
823:. Academic Press. p. 367.
799:from the original on 2017-04-19
726:from the original on 2019-12-15
578:from the original on 2017-04-14
856:Eisenbarth, George S. (2011).
1:
1905:Postorgasmic illness syndrome
1342:Disorders involving multiple
1962:Hypersensitivity pneumonitis
1377:Multiple endocrine neoplasia
1048:Journal of Internal Medicine
471:Basic clinical endocrinology
2028:Systemic autoimmune disease
1864:Allergic contact dermatitis
1784:Hypersensitivity vasculitis
1667:Autoimmune hemolytic anemia
1003:Annals of Internal Medicine
361:Thyroid-stimulating hormone
114:Thyroid-stimulating hormone
2079:
1534:common allergies include:
787:Reference, Genetics Home.
15:
1421:Woodhouse–Sakati syndrome
1350:
750:American Family Physician
610:10.1016/j.lpm.2012.09.011
438:rarediseases.info.nih.gov
51:
42:
1779:Henoch–Schönlein purpura
1594:Eosinophilic esophagitis
54:human leukocyte antigens
1895:Hashimoto's thyroiditis
1682:Guillain–Barré syndrome
997:Mandel, Lee R. (2009).
793:Genetics Home Reference
299:, while it is done for
266:human leukocyte antigen
145:human leukocyte antigen
1996:Autoimmune adrenalitis
1124:Autoimmune Diagnostics
909:10.1210/jc.2002-021845
685:10.1210/edrv.23.3.0466
572:emedicine.medscape.com
340:
257:
175:
131:and either autoimmune
1127:. Walter de Gruyter.
1121:Renz, Harald (2012).
335:
251:
218:Hashimoto thyroiditis
174:Hashimoto thyroiditis
173:
2001:Autoimmune hepatitis
1980:Transplant rejection
1890:Giant cell arteritis
1820:Rheumatoid arthritis
1677:Goodpasture syndrome
1589:Autoimmune urticaria
376:Martin Benno Schmidt
270:genetically speaking
2058:Autoimmune diseases
1467:autoimmune diseases
958:10.1530/EJE-09-0044
382:Society and culture
352:Isohormonal therapy
303:of this condition,
52:HLA-DQ2 one of the
2053:Endocrine diseases
1910:Reactive arthritis
1900:Multiple sclerosis
1794:Reactive arthritis
1692:Pemphigus vulgaris
1672:Bullous pemphigoid
1573:Penicillin allergy
1509:Allergic urticaria
1372:Carcinoid syndrome
1246:External resources
598:La Presse MĂ©dicale
341:
262:autosomal dominant
258:
210:Hypoparathyroidism
176:
163:Signs and symptoms
37:Schmidt's syndrome
2040:
2039:
2036:
2035:
1941:
1940:
1833:
1832:
1742:
1741:
1738:
1737:
1730:Pernicious anemia
1725:Myasthenia gravis
1602:
1601:
1525:Atopic dermatitis
1514:Allergic rhinitis
1429:
1428:
1280:
1279:
672:Endocrine Reviews
604:(12): e663–e670.
486:978-0-07-140297-2
238:Diabetes mellitus
129:Addison's disease
118:
117:
102:Diagnostic method
22:Medical condition
2070:
2023:Sjögren syndrome
1952:
1854:
1759:
1655:
1634:
1494:
1463:Hypersensitivity
1456:
1449:
1442:
1433:
1344:endocrine glands
1336:
1329:
1322:
1313:
1289:
1288:
1162:
1145:
1143:
1141:
1117:
1115:
1113:
1089:
1063:
1029:
1028:
1018:
994:
988:
985:
979:
978:
960:
936:
930:
929:
911:
902:(7): 2983–2992.
887:
881:
880:
878:
876:
853:
847:
846:
844:
842:
814:
808:
807:
805:
804:
784:
778:
777:
775:
773:
741:
735:
734:
732:
731:
712:
706:
705:
687:
663:
657:
656:
636:
630:
629:
593:
587:
586:
584:
583:
564:
551:
550:
540:
500:
491:
490:
474:
464:
453:
452:
450:
449:
440:. Archived from
430:
76:
75:
47:
25:
2078:
2077:
2073:
2072:
2071:
2069:
2068:
2067:
2043:
2042:
2041:
2032:
1984:
1947:
1937:
1919:
1915:Type 1 diabetes
1885:Coeliac disease
1873:
1845:
1829:
1803:
1769:Arthus reaction
1750:
1734:
1720:Graves' disease
1701:
1697:Rheumatic fever
1646:
1614:
1598:
1577:
1504:Allergic asthma
1485:
1469:
1460:
1430:
1425:
1404:Werner syndrome
1346:
1340:
1310:
1309:
1308:
1290:
1286:
1281:
1276:
1275:
1241:
1240:
1173:
1152:
1139:
1137:
1135:
1120:
1111:
1109:
1107:
1092:
1041:
1038:
1036:Further reading
1033:
1032:
996:
995:
991:
986:
982:
938:
937:
933:
889:
888:
884:
874:
872:
870:
855:
854:
850:
840:
838:
831:
816:
815:
811:
802:
800:
786:
785:
781:
771:
769:
743:
742:
738:
729:
727:
714:
713:
709:
665:
664:
660:
638:
637:
633:
595:
594:
590:
581:
579:
566:
565:
554:
502:
501:
494:
487:
466:
465:
456:
447:
445:
432:
431:
420:
415:
398:
389:John F. Kennedy
387:U.S. President
384:
372:
356:Glucocorticoids
330:
297:genetic testing
293:
246:
223:Graves' disease
165:
137:type 1 diabetes
133:thyroid disease
106:Ultrasound, MRI
70:
23:
20:
12:
11:
5:
2076:
2074:
2066:
2065:
2060:
2055:
2045:
2044:
2038:
2037:
2034:
2033:
2031:
2030:
2025:
2020:
2019:
2018:
2013:
2003:
1998:
1992:
1990:
1986:
1985:
1983:
1982:
1977:
1971:
1970:
1969:
1958:
1956:
1949:
1943:
1942:
1939:
1938:
1936:
1935:
1929:
1927:
1921:
1920:
1918:
1917:
1912:
1907:
1902:
1897:
1892:
1887:
1881:
1879:
1875:
1874:
1872:
1871:
1866:
1860:
1858:
1851:
1835:
1834:
1831:
1830:
1828:
1827:
1822:
1817:
1811:
1809:
1805:
1804:
1802:
1801:
1799:Serum sickness
1796:
1791:
1786:
1781:
1776:
1771:
1765:
1763:
1756:
1753:Immune complex
1744:
1743:
1740:
1739:
1736:
1735:
1733:
1732:
1727:
1722:
1716:
1714:
1703:
1702:
1700:
1699:
1694:
1689:
1684:
1679:
1674:
1669:
1663:
1661:
1652:
1648:
1647:
1645:
1640:
1638:
1631:
1630:
1629:
1628:
1627:
1622:
1604:
1603:
1600:
1599:
1597:
1596:
1591:
1585:
1583:
1579:
1578:
1576:
1575:
1570:
1569:
1568:
1563:
1558:
1553:
1548:
1543:
1538:
1527:
1522:
1517:
1511:
1506:
1500:
1498:
1491:
1471:
1470:
1461:
1459:
1458:
1451:
1444:
1436:
1427:
1426:
1424:
1423:
1418:
1417:
1416:
1411:
1406:
1396:
1395:
1394:
1389:
1384:
1374:
1369:
1368:
1367:
1362:
1351:
1348:
1347:
1341:
1339:
1338:
1331:
1324:
1316:
1291:
1284:
1283:
1282:
1278:
1277:
1274:
1273:
1262:
1250:
1249:
1247:
1243:
1242:
1239:
1238:
1227:
1216:
1205:
1190:
1174:
1169:
1168:
1166:
1165:Classification
1159:
1158:
1151:
1150:External links
1148:
1147:
1146:
1133:
1118:
1105:
1099:. OUP Oxford.
1090:
1054:(5): 530–540.
1037:
1034:
1031:
1030:
1009:(5): 350–354.
989:
980:
931:
882:
868:
848:
829:
809:
779:
736:
707:
678:(3): 327–364.
658:
631:
588:
552:
515:(2): 225–233.
492:
485:
454:
417:
416:
414:
411:
410:
409:
404:
397:
394:
393:
392:
383:
380:
371:
368:
367:
366:
363:
358:
353:
350:
338:glucocorticoid
329:
326:
325:
324:
319:
314:
292:
289:
285:autoantibodies
245:
242:
241:
240:
235:
230:
225:
220:
215:
212:
207:
205:blood pressure
201:
196:
193:
188:
182:
164:
161:
116:
115:
112:
108:
107:
104:
98:
97:
94:
88:
87:
84:
78:
77:
64:
58:
57:
49:
48:
40:
39:
34:
30:
29:
21:
13:
10:
9:
6:
4:
3:
2:
2075:
2064:
2061:
2059:
2056:
2054:
2051:
2050:
2048:
2029:
2026:
2024:
2021:
2017:
2014:
2012:
2009:
2008:
2007:
2004:
2002:
1999:
1997:
1994:
1993:
1991:
1987:
1981:
1978:
1975:
1974:Latex allergy
1972:
1968:
1965:
1964:
1963:
1960:
1959:
1957:
1953:
1950:
1944:
1934:
1931:
1930:
1928:
1926:
1922:
1916:
1913:
1911:
1908:
1906:
1903:
1901:
1898:
1896:
1893:
1891:
1888:
1886:
1883:
1882:
1880:
1876:
1870:
1867:
1865:
1862:
1861:
1859:
1855:
1852:
1849:
1844:
1843:cell-mediated
1840:
1836:
1826:
1823:
1821:
1818:
1816:
1813:
1812:
1810:
1806:
1800:
1797:
1795:
1792:
1790:
1787:
1785:
1782:
1780:
1777:
1775:
1774:Farmer's lung
1772:
1770:
1767:
1766:
1764:
1760:
1757:
1754:
1749:
1745:
1731:
1728:
1726:
1723:
1721:
1718:
1717:
1715:
1713:
1709:
1704:
1698:
1695:
1693:
1690:
1688:
1685:
1683:
1680:
1678:
1675:
1673:
1670:
1668:
1665:
1664:
1662:
1660:
1656:
1653:
1649:
1644:
1641:
1639:
1635:
1632:
1626:
1623:
1621:
1618:
1617:
1616:
1615:
1613:
1609:
1605:
1595:
1592:
1590:
1587:
1586:
1584:
1580:
1574:
1571:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1537:
1533:
1532:
1531:
1528:
1526:
1523:
1521:
1518:
1515:
1512:
1510:
1507:
1505:
1502:
1501:
1499:
1495:
1492:
1489:
1484:
1480:
1476:
1472:
1468:
1464:
1457:
1452:
1450:
1445:
1443:
1438:
1437:
1434:
1422:
1419:
1415:
1412:
1410:
1407:
1405:
1402:
1401:
1400:
1397:
1393:
1390:
1388:
1385:
1383:
1380:
1379:
1378:
1375:
1373:
1370:
1366:
1363:
1361:
1358:
1357:
1356:
1353:
1352:
1349:
1345:
1337:
1332:
1330:
1325:
1323:
1318:
1317:
1314:
1306:
1305:
1304:
1298:
1294:
1272:
1268:
1267:
1263:
1261:
1257:
1256:
1252:
1251:
1248:
1244:
1237:
1233:
1232:
1228:
1226:
1222:
1221:
1217:
1215:
1211:
1210:
1206:
1204:
1200:
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295:In terms of
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233:Hypogonadism
191:Palpitations
166:
123:, a form of
120:
119:
92:Risk factors
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36:
1520:Anaphylaxis
1516:(Hay fever)
647:(1): 9–33.
641:Acta Biomed
281:lymphocytes
195:Weight loss
33:Other names
2047:Categories
1989:Autoimmune
1878:Autoimmune
1808:Autoimmune
1651:Autoimmune
1582:Autoimmune
1231:DiseasesDB
803:2017-04-19
730:2017-04-13
582:2017-04-13
448:2017-04-12
413:References
322:Ultrasound
254:haplotypes
16:See also:
2063:Syndromes
1659:Cytotoxic
1414:Metageria
1409:Acrogeria
1255:eMedicine
1086:205340006
1070:1365-2796
967:1479-683X
918:0021-972X
694:0163-769X
618:0755-4982
529:0009-9104
328:Treatment
291:Diagnosis
186:urination
184:Frequent
111:Treatment
62:Specialty
1948:multiple
1946:Unknown/
1748:Type III
1712:receptor
1561:Tree nut
1399:Progeria
1266:Orphanet
1260:med/1868
1140:19 April
1112:19 April
1078:19382992
1025:19721023
975:19411300
926:12843130
875:13 April
841:19 April
835:Archived
797:Archived
772:13 April
766:Archived
762:17375512
724:Archived
720:omim.org
702:12050123
653:12817789
626:23159534
576:Archived
547:15270837
396:See also
336:Type of
244:Genetics
214:Myalgias
199:Anorexia
86:Asplenia
82:Symptoms
1955:Foreign
1857:Foreign
1848:T cells
1839:Type IV
1762:Foreign
1637:Foreign
1608:Type II
1551:Seafood
1497:Foreign
1479:allergy
1293:Scholia
1225:D016884
538:1809126
370:History
312:CT scan
275:Should
228:Anaemia
157:HLA-DR4
153:HLA-DQ8
149:HLA-DQ2
1976:(I+IV)
1708:Type V
1546:Peanut
1475:Type I
1295:has a
1214:269200
1156:PubMed
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305:type 2
301:type 1
180:Nausea
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1815:Lupus
1566:Wheat
1483:atopy
1297:topic
1236:29690
1203:258.1
1188:E31.0
1082:S2CID
2016:APS2
2011:APS1
1925:GVHD
1612:ADCC
1541:Milk
1465:and
1365:APS2
1360:APS1
1271:3143
1220:MeSH
1209:OMIM
1198:9-CM
1142:2017
1129:ISBN
1114:2017
1101:ISBN
1074:PMID
1066:ISSN
1021:PMID
971:PMID
963:ISSN
922:PMID
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877:2017
864:ISBN
843:2017
825:ISBN
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758:PMID
698:PMID
690:ISSN
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622:PMID
614:ISSN
543:PMID
525:ISSN
481:ISBN
252:HLA(
203:Low
155:and
141:gene
1625:IgM
1620:IgG
1556:Soy
1536:Egg
1488:IgE
1194:ICD
1179:ICD
1056:doi
1052:265
1011:doi
1007:151
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680:doi
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533:PMC
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
