348:
InChI=1S/C65H82N18O13/c1-35(2)25-47(56(88)74-46(13-7-23-70-64(66)67)63(95)83-24-8-14-53(83)62(94)81-82-65(68)96)75-58(90)49(28-37-15-18-38-9-3-4-10-39(38)26-37)76-57(89)48(27-36-16-19-42(85)20-17-36)77-61(93)52(33-84)80-59(91)50(29-40-31-71-44-12-6-5-11-43(40)44)78-60(92)51(30-41-32-69-34-72-41)79-55(87)45-21-22-54(86)73-45/h3-6,9-12,15-20,26,31-32,34-35,45-53,71,84-85H,7-8,13-14,21-25,27-30,33H2,1-2H3,(H,69,72)(H,73,86)(H,74,88)(H,75,90)(H,76,89)(H,77,93)(H,78,92)(H,79,87)(H,80,91)(H,81,94)(H4,66,67,70)(H3,68,82,96)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/m0/s1
306:
229:
29:
1806:
1405:
525:
Bulldan A, Shihan M, Goericke-Pesch S, Scheiner-Bobis G (December 2016). "Signaling events associated with gonadotropin releasing hormone-agonist-induced hormonal castration and its reversal in canines".
1398:
328:
CC(C(NC((NC((NC((NC((NC((NC(1CCC(N1)=O)=O)CC2=CN=CN2)=O)CC3=CNC4=CC=CC=C43)=O)CO)=O)CC5=CC=C(O)C=C5)=O)CC6=CC7=CC=CC=C7C=C6)=O)C(N(C(N8CCC8C(NNC(N)=O)=O)=O)CCC/N=C(N)\N)=O)C
1391:
1354:
54:
6--1-9-luteinizing hormone-releasing factor (swine) 2-(aminocarbonyl)hydrazide; 6--10-deglycinamide-luteinizing hormone-releasing factor (pig) 2-(aminocarbonyl)hydrazide
802:
1662:
320:
153:-imidazol-5-yl)-9-isobutyl-12-(naphthalen-2-ylmethyl)-8,11,14,17,20,23-hexaoxo-2,7,10,13,16,19,22-heptaazapentacos-1-en-24-yl)-5-oxopyrrolidine-2-carboxamide
1372:
972:
922:
828:
1434:
1414:
836:
437:
755:
409:
in animals such as male dogs, cats, and others, but is no longer or was never commercially available. The medication has also been used to treat
1087:
846:
371:
1847:
1711:
1321:
738:
709:
664:
623:
509:
475:
1383:
1367:
1362:
795:
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1057:
340:
1871:
788:
97:
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1127:
811:
1735:
1686:
1270:
1009:
1004:
410:
188:
1886:
1338:
1278:
208:
1881:
1840:
1169:
996:
780:
756:"Optimization of breeding of salmonids: Gonazon, the first officially approved inducer of ovulation in the EU"
1681:
1326:
59:
1866:
1538:
1232:
406:
149:)-2-(2-carbamoylhydrazine-1-carbonyl)pyrrolidine-1-carbonyl)-15-(4-hydroxybenzyl)-18-(hydroxymethyl)-25-(1
1765:
1750:
1876:
1653:
1423:
1262:
1224:
763:
1833:
1730:
1274:
428:, and was the first GnRH agonist to be available for use in fish. It was introduced for use by 2005.
70:
224:
1691:
1266:
1190:
1110:
1014:
375:
162:
1523:
1426:
1244:
1194:
678:
551:
402:
387:
66:
1606:
1533:
501:
Pharmakotherapie bei Haus- und
Nutztieren: Begründet von W. Löscher, F.R. Ungemach und R. Kroker
1781:
1616:
1611:
1596:
1576:
1561:
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1508:
1458:
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734:
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705:
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670:
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640:
619:
611:
592:
571:"New approaches to non-surgical sterilization for dogs and cats: Opportunities and challenges"
543:
505:
499:
471:
463:
41:
1591:
413:
in animals. In addition to its use in mammals, azagly-nafarelin has been approved for use in
1745:
1740:
1240:
1173:
1165:
1143:
652:
582:
535:
245:
197:
171:
1236:
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1760:
1332:
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1214:
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1024:
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383:
682:
555:
1813:
1120:
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82:
20:
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912:
897:
877:
414:
394:
754:
Haffray P, Enright WJ, Driancourt MA, Mikolajczyk T, Rault P, Breton B (2005).
656:
28:
1755:
1701:
1628:
1566:
1478:
1473:
1298:
1228:
1019:
963:
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872:
867:
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77:
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674:
596:
547:
1805:
1633:
1623:
1601:
1551:
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958:
933:
425:
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704:. Schlütersche Verlagsgesellschaft mbH & Company KG. pp. 286–.
1663:
1556:
1293:
390:
177:
587:
570:
539:
727:"Promoting oocyte maturation, ovulation, and spawning in farmed fish"
379:
731:
The Fish Oocyte: From Basic
Studies to Biotechnological Applications
305:
296:
417:
1435:
1415:
1387:
784:
1088:
1712:
213:
645:
Veterinary
Clinics of North America: Small Animal Practice
733:. Springer Science & Business Media. pp. 444–.
397:. The medication has been approved in Europe as a solid
1821:
1668:
Tooltip
Luteinizing hormone/choriogonadotropin receptor
1773:
1355:
1154:
1128:
1121:
1058:
829:
812:
498:
Löscher W, Richter A, Potschka H (3 September 2014).
493:
491:
489:
487:
1710:
1661:
1652:
1433:
1152:Sex steroid agonists (via negative feedback on the
1142:
1046:
1037:
995:
986:
921:
845:
827:
294:
277:
244:
239:
207:
187:
161:
88:
76:
58:
50:
40:
35:
1056:Sex steroid antagonists (via disinhibition of the
438:Gonadotropin-releasing hormone receptor § Agonists
1440:Tooltip Gonadotropin-releasing hormone receptor
1420:Tooltip Gonadotropin-releasing hormone receptor
575:Reproduction in Domestic Animals = Zuchthygiene
170:
1291:Others (mixed or unknown mechanism of action):
1093:Tooltip Selective estrogen receptor modulators
457:
455:
453:
1841:
1717:Tooltip Follicle-stimulating hormone receptor
1399:
796:
8:
19:
616:Animal Andrology: Theories and Applications
374:(GnRH agonist) medication which is used in
1848:
1834:
1756:Menotropin (human menopausal gonadotropin)
1702:Menotropin (human menopausal gonadotropin)
1658:
1406:
1392:
1384:
1043:
992:
842:
803:
789:
781:
729:. In Babin PJ, CerdĂ J, Lubzens E (eds.).
702:Klinik der Reproduktionsmedizin des Hundes
227:
586:
196:
651:(4). Elsevier Health Sciences: 701–719.
462:Driancourt MA, Rodes L (29 June 2018).
449:
345:
325:
223:
102:
1133:Tooltip gonadotropin-releasing hormone
817:Tooltip Gonadotropin-releasing hormone
725:Mylonas CC, Zohar Y (20 August 2007).
610:Norman ST, Collop TM (30 April 2014).
528:Molecular Reproduction and Development
470:. Elsevier Science. pp. 554–556.
464:"Male Contraception in Animal Species"
372:gonadotropin-releasing hormone agonist
18:
7:
1802:
1800:
1358:and gonadotropin receptor modulators
614:. In Chenoweth PJ, Lorton S (eds.).
145:-indol-3-yl)methyl)-1,1-diamino-6-((
14:
1373:Progestogens and antiprogestogens
973:+estradiol/norethisterone acetate
1804:
698:"Hormonbehandlung bei der HĂĽdin"
262:
256:
27:
353:Key:FDOMSRGNWHJMGI-XRSSZCMZSA-N
268:
250:
1:
696:Dreier HK (6 December 2010).
1820:. You can help Knowledge by
1736:Follicle-stimulating hormone
1687:Human chorionic gonadotropin
1271:hydroxyprogesterone caproate
1010:Human chorionic gonadotropin
1005:Follicle-stimulating hormone
639:Christensen BW (July 2018).
468:Encyclopedia of Reproduction
411:benign prostatic hyperplasia
366:, sold under the brand name
1368:Estrogens and antiestrogens
1363:Androgens and antiandrogens
1279:medroxyprogesterone acetate
612:"Male Animal Contraception"
1903:
1799:
657:10.1016/j.cvsm.2018.02.012
420:, specifically to control
240:Chemical and physical data
1316:
641:"Canine Prostate Disease"
336:
316:
93:
26:
1504:Leuprorelin (leuprolide)
898:Leuprorelin (leuprolide)
1682:Choriogonadotropin alfa
618:. CABI. pp. 489–.
569:Rhodes L (April 2017).
504:. Enke. pp. 435–.
466:. In Skinner MK (ed.).
1872:Hormonal contraception
1816:-related article is a
1539:Zoptarelin doxorubicin
1617:Teverelix (antarelix)
1424:gonadotropin receptor
1263:chlormadinone acetate
1731:Corifollitropin alfa
1597:Ornirelix (ornitide)
1275:gestonorone caproate
1111:Aromatase inhibitors
581:(Suppl 2): 327–331.
1766:Varfollitropin alfa
1751:Follitropin epsilon
1692:Luteinizing hormone
1267:cyproterone acetate
1195:prolactin releasers
1015:Luteinizing hormone
376:veterinary medicine
23:
1887:Pharmacology stubs
1343:Never to phase III
1245:diethylstilbestrol
1829:
1828:
1794:
1793:
1790:
1789:
1587:Iturelix (antide)
1381:
1380:
1312:
1311:
1283:megestrol acetate
1174:nandrolone esters
1166:anabolic steroids
1144:Antigonadotropins
1033:
1032:
982:
981:
760:World Aquaculture
740:978-1-4020-6233-9
711:978-3-8426-8038-8
666:978-0-323-61085-8
625:978-1-78064-316-8
588:10.1111/rda.12862
540:10.1002/mrd.22751
534:(12): 1092–1101.
511:978-3-8304-1251-9
477:978-0-12-815145-7
393:, specifically a
361:
360:
307:Interactive image
209:CompTox Dashboard
16:Chemical compound
1894:
1882:Veterinary drugs
1850:
1843:
1836:
1808:
1801:
1775:
1746:Follitropin beta
1741:Follitropin alfa
1718:
1714:
1669:
1665:
1659:
1464:Azagly-nafarelin
1441:
1437:
1421:
1417:
1408:
1401:
1394:
1385:
1357:
1241:ethinylestradiol
1237:estradiol esters
1156:
1134:
1130:
1123:
1094:
1090:
1060:
1048:Progonadotropins
1044:
993:
858:Azagly-nafarelin
843:
831:
818:
814:
805:
798:
791:
782:
775:
774:
772:
771:
762:. Archived from
751:
745:
744:
722:
716:
715:
693:
687:
686:
636:
630:
629:
607:
601:
600:
590:
566:
560:
559:
522:
516:
515:
495:
482:
481:
459:
364:Azagly-nafarelin
309:
289:
287:
270:
264:
258:
252:
232:
231:
217:
215:
200:
174:
31:
24:
22:
21:Azagly-nafarelin
1902:
1901:
1897:
1896:
1895:
1893:
1892:
1891:
1857:
1856:
1855:
1854:
1797:
1795:
1786:
1716:
1706:
1667:
1648:
1439:
1429:
1419:
1412:
1382:
1377:
1348:
1333:Clinical trials
1308:
1187:
1138:
1132:
1092:
1039:
1029:
978:
917:
834:
823:
816:
809:
779:
778:
769:
767:
753:
752:
748:
741:
724:
723:
719:
712:
695:
694:
690:
667:
638:
637:
633:
626:
609:
608:
604:
568:
567:
563:
524:
523:
519:
512:
497:
496:
485:
478:
461:
460:
451:
446:
434:
357:
354:
349:
344:
343:
332:
329:
324:
323:
312:
285:
283:
273:
267:
261:
255:
235:
211:
203:
183:
175:
157:
154:
101:
100:
61:
17:
12:
11:
5:
1900:
1898:
1890:
1889:
1884:
1879:
1874:
1869:
1859:
1858:
1853:
1852:
1845:
1838:
1830:
1827:
1826:
1809:
1792:
1791:
1788:
1787:
1785:
1784:
1769:
1768:
1763:
1761:Urofollitropin
1758:
1753:
1748:
1743:
1738:
1733:
1721:
1719:
1708:
1707:
1705:
1704:
1699:
1694:
1689:
1684:
1672:
1670:
1656:
1650:
1649:
1647:
1646:
1641:
1636:
1631:
1626:
1614:
1609:
1604:
1599:
1594:
1589:
1584:
1579:
1574:
1569:
1564:
1559:
1554:
1542:
1541:
1536:
1531:
1526:
1521:
1516:
1511:
1506:
1501:
1496:
1491:
1486:
1481:
1476:
1471:
1466:
1461:
1456:
1444:
1442:
1431:
1430:
1413:
1411:
1410:
1403:
1396:
1388:
1379:
1378:
1376:
1375:
1370:
1365:
1360:
1352:
1347:
1346:
1345:
1344:
1341:
1330:
1324:
1318:
1317:
1314:
1313:
1310:
1309:
1307:
1306:
1301:
1296:
1287:
1286:
1252:
1249:paroxypropione
1222:
1215:chlorpromazine
1203:metoclopramide
1185:
1181:
1148:
1146:
1140:
1139:
1137:
1136:
1118:
1108:
1081:
1052:
1050:
1041:
1035:
1034:
1031:
1030:
1028:
1027:
1025:Urofollitropin
1022:
1017:
1012:
1007:
1001:
999:
990:
984:
983:
980:
979:
977:
976:
966:
961:
952:
951:
946:
941:
936:
927:
925:
919:
918:
916:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
851:
849:
840:
825:
824:
810:
808:
807:
800:
793:
785:
777:
776:
746:
739:
717:
710:
688:
665:
631:
624:
602:
561:
517:
510:
483:
476:
448:
447:
445:
442:
441:
440:
433:
430:
401:-based matrix
359:
358:
356:
355:
352:
350:
347:
339:
338:
337:
334:
333:
331:
330:
327:
319:
318:
317:
314:
313:
311:
310:
302:
300:
292:
291:
281:
275:
274:
271:
265:
259:
253:
248:
242:
241:
237:
236:
234:
233:
225:DTXSID30873507
220:
218:
205:
204:
202:
201:
193:
191:
185:
184:
182:
181:
167:
165:
159:
158:
156:
155:
104:
96:
95:
94:
91:
90:
86:
85:
80:
74:
73:
64:
62:administration
56:
55:
52:
48:
47:
44:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
1899:
1888:
1885:
1883:
1880:
1878:
1875:
1873:
1870:
1868:
1867:GnRH agonists
1865:
1864:
1862:
1851:
1846:
1844:
1839:
1837:
1832:
1831:
1825:
1823:
1819:
1815:
1810:
1807:
1803:
1798:
1783:
1780:
1779:Non-peptides:
1777:
1771:
1770:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1726:
1723:
1722:
1720:
1715:
1709:
1703:
1700:
1698:
1697:Lutropin alfa
1695:
1693:
1690:
1688:
1685:
1683:
1680:
1677:
1674:
1673:
1671:
1666:
1660:
1657:
1655:
1651:
1645:
1642:
1640:
1637:
1635:
1632:
1630:
1627:
1625:
1622:
1621:Non-peptides:
1618:
1615:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1580:
1578:
1575:
1573:
1570:
1568:
1565:
1563:
1560:
1558:
1555:
1553:
1550:
1547:
1544:
1543:
1540:
1537:
1535:
1532:
1530:
1527:
1525:
1522:
1520:
1517:
1515:
1512:
1510:
1507:
1505:
1502:
1500:
1497:
1495:
1492:
1490:
1487:
1485:
1482:
1480:
1477:
1475:
1472:
1470:
1467:
1465:
1462:
1460:
1457:
1455:
1452:
1449:
1446:
1445:
1443:
1438:
1432:
1428:
1425:
1418:
1409:
1404:
1402:
1397:
1395:
1390:
1389:
1386:
1374:
1371:
1369:
1366:
1364:
1361:
1359:
1353:
1350:
1349:
1342:
1340:
1337:
1336:
1334:
1331:
1328:
1325:
1323:
1320:
1319:
1315:
1305:
1302:
1300:
1297:
1295:
1292:
1289:
1288:
1284:
1280:
1276:
1272:
1268:
1264:
1260:
1256:
1253:
1250:
1246:
1242:
1238:
1234:
1230:
1226:
1223:
1220:
1216:
1212:
1208:
1204:
1200:
1196:
1192:
1189:
1182:
1179:
1175:
1171:
1167:
1163:
1160:
1158:
1150:
1149:
1147:
1145:
1141:
1131:
1125:
1119:
1116:
1112:
1109:
1106:
1102:
1098:
1091:
1085:
1084:Antiestrogens
1082:
1079:
1075:
1071:
1067:
1066:Antiandrogens
1064:
1062:
1054:
1053:
1051:
1049:
1045:
1042:
1036:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1002:
1000:
998:
994:
991:
989:
988:Gonadotropins
985:
974:
970:
967:
965:
962:
960:
957:
954:
953:
950:
947:
945:
942:
940:
937:
935:
932:
929:
928:
926:
924:
920:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
853:
852:
850:
848:
844:
841:
838:
833:
826:
822:
821:gonadotropins
815:
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766:on 2018-07-29
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416:
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407:contraceptive
405:for use as a
404:
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396:
392:
389:
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384:GnRH analogue
381:
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176:113962-45-1 (
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36:Clinical data
34:
30:
25:
1877:Decapeptides
1822:expanding it
1814:pharmacology
1811:
1796:
1778:
1772:
1727:
1724:
1678:
1675:
1654:Gonadotropin
1620:
1548:
1546:Antagonists:
1545:
1463:
1450:
1447:
1290:
1255:Progestogens
1170:testosterone
1151:
1078:enzalutamide
1074:bicalutamide
1055:
997:Preparations
956:Non-peptide:
955:
930:
857:
854:
768:. Retrieved
764:the original
759:
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83:GnRH agonist
1529:Triptorelin
1524:Salmon GnRH
1489:Gonadorelin
1329:from market
1304:Metallibure
1211:haloperidol
1207:risperidone
1199:domperidone
1191:antagonists
1178:oxandrolone
1115:anastrozole
1105:enclomifene
923:Antagonists
913:Triptorelin
878:Gonadorelin
415:aquaculture
395:decapeptide
290: g·mol
89:Identifiers
51:Other names
42:Trade names
1861:Categories
1629:Linzagolix
1607:Prazarelix
1567:Cetrorelix
1534:Zoptarelin
1479:Fertirelin
1474:Deslorelin
1427:modulators
1299:Gestrinone
1259:progestins
1229:bifluranol
1197:) (incl.,
1040:(indirect)
1020:Menotropin
964:Linzagolix
939:Cetrorelix
873:Fertirelin
868:Deslorelin
832:modulators
770:2018-07-29
444:References
382:. It is a
295:3D model (
279:Molar mass
198:2N7D33X56N
172:91991-07-0
163:CAS Number
98:IUPAC name
78:Drug class
1782:ADX-61623
1728:Peptides:
1725:Agonists:
1679:Peptides:
1676:Agonists:
1644:Sufugolix
1639:Relugolix
1612:Ramorelix
1582:Ganirelix
1577:Detirelix
1572:Degarelix
1562:Azaline B
1549:Peptides:
1519:Peforelin
1514:Nafarelin
1499:Histrelin
1494:Goserelin
1469:Buserelin
1451:Peptides:
1448:Agonists:
1339:Phase III
1327:Withdrawn
1233:estradiol
1225:Estrogens
1219:sulpiride
1162:Androgens
1101:clomifene
1097:tamoxifen
1070:flutamide
969:Relugolix
949:Ganirelix
944:Degarelix
908:Peforelin
903:Nafarelin
893:Lecirelin
888:Histrelin
883:Goserelin
863:Buserelin
837:analogues
426:salmonids
422:ovulation
388:synthetic
71:Injection
60:Routes of
1634:Opigolix
1624:Elagolix
1602:Ozarelix
1552:Abarelix
1509:Lutrelin
1459:Avorelin
1454:Alarelin
1351:See also
1261:, e.g.,
1227:(incl.,
1188:receptor
1124:agonists
959:Elagolix
934:Abarelix
931:Peptide:
855:Peptide:
847:Agonists
683:49381344
675:29933768
597:27892642
556:29559009
548:27764533
432:See also
399:silicone
141:)-21-((1
1592:LXT-101
1557:Acyline
1294:Danazol
1257:(incl.
1168:(e.g.,
1126:(e.g.,
1113:(e.g.,
1095:(e.g.,
1068:(e.g.,
835:(incl.
403:implant
391:peptide
370:, is a
368:Gonazon
246:Formula
178:acetate
67:Implant
46:Gonazon
1664:LH/hCG
1322:WHO-EM
1038:Others
737:
708:
681:
673:
663:
622:
595:
554:
546:
508:
474:
386:and a
380:Europe
321:SMILES
1812:This
1089:SERMs
679:S2CID
552:S2CID
341:InChI
297:JSmol
1818:stub
1774:NAMs
1484:GnRH
1436:GnRH
1422:and
1416:GnRH
1356:GnRH
1157:axis
1129:GnRH
1122:GnRH
1061:axis
830:GnRH
819:and
813:GnRH
735:ISBN
706:ISBN
671:PMID
661:ISBN
620:ISBN
593:PMID
544:PMID
506:ISBN
472:ISBN
418:fish
288:.484
189:UNII
113:-((6
1713:FSH
1155:HPG
1059:HPG
653:doi
583:doi
536:doi
424:in
378:in
286:323
214:EPA
137:,24
133:,21
129:,18
125:,15
121:,12
1863::
1619:;
1335::
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1277:,
1273:,
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1159:):
1103:,
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758:.
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649:48
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643:.
591:.
579:52
577:.
573:.
550:.
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532:83
530:.
486:^
452:^
272:13
266:18
260:82
254:65
117:,9
109:)-
69:;
1849:e
1842:t
1835:v
1824:.
1776::
1407:e
1400:t
1393:v
1285:)
1251:)
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1193:(
1186:2
1184:D
1180:)
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1107:)
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971:(
839:)
804:e
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685:.
655::
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538::
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480:.
299:)
284:1
269:O
263:N
257:H
251:C
216:)
212:(
180:)
151:H
147:S
143:H
139:S
135:S
131:S
127:S
123:R
119:S
115:S
111:N
107:S
105:(
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