1559:
29:
419:
Jantas D, Greda A, Leskiewicz M, Grygier B, Pilc A, Lason W (September 2015). "Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation".
383:
Rossi F, Marabese I, De Chiaro M, Boccella S, Luongo L, Guida F, et al. (June 2014). "Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions".
530:
523:
465:"Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State"
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516:
1604:
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206:
192:
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336:"Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds"
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InChI=1S/C19H22BrNOS/c1-3-14(2)16-6-10-18(11-7-16)21-19(22)13-23-12-15-4-8-17(20)9-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,21,22)
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Duvoisin RM, Pfankuch T, Wilson JM, Grabell J, Chhajlani V, Brown DG, et al. (October 2010).
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260:, and is used for research into the role of this receptor subtype in various processes including
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287:"Acute pharmacological modulation of mGluR8 reduces measures of anxiety"
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Jantas D, Grygier B, Zatorska J, Lasoń W (October 2018).
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469:Basic & Clinical Pharmacology & Toxicology
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334:Reed BT, Morgans CW, Duvoisin RM (April 2013).
252:is a drug which acts as a potent and selective
73:
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524:
8:
19:
214:CCC(C)C1=CC=C(C=C1)NC(=O)CSCC2=CC=C(C=C2)Br
1605:
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855:
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118:
27:
1543:Glutamate metabolism/transport modulators
1450:Tooltip Metabotropic glutamate receptor 8
1351:Tooltip Metabotropic glutamate receptor 7
1279:Tooltip Metabotropic glutamate receptor 6
1175:Tooltip Metabotropic glutamate receptor 4
1026:Tooltip Metabotropic glutamate receptor 3
868:Tooltip Metabotropic glutamate receptor 2
682:Tooltip Metabotropic glutamate receptor 5
568:Tooltip Metabotropic glutamate receptor 1
480:
359:
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1539:Ionotropic glutamate receptor modulators
277:
231:
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49:
18:
7:
1555:
1553:
1082:Pomaglumetad methionil (LY-2140023)
934:Pomaglumetad methionil (LY-2140023)
89:
1577:. You can help Knowledge (XXG) by
14:
258:metabotropic glutamate receptor 8
1557:
352:10.1016/j.neuropharm.2012.09.023
155:
146:
1478:Positive allosteric modulators:
1429:Negative allosteric modulators:
1218:Positive allosteric modulators:
1136:Negative allosteric modulators:
1000:Negative allosteric modulators:
943:Positive allosteric modulators:
799:Negative allosteric modulators:
742:Positive allosteric modulators:
540:Metabotropic glutamate receptor
239:Key:QKUYZJOTWYRWNF-UHFFFAOYSA-N
152:
161:
158:
140:
56:-(4-butan-2-ylphenyl)acetamide
1:
1535:Receptor/signaling modulators
254:positive allosteric modulator
434:10.1016/j.neuint.2014.12.011
422:Neurochemistry International
1660:
1552:
386:Journal of Neurophysiology
291:Behavioural Brain Research
130:Chemical and physical data
1644:Nervous system drug stubs
1528:
1067:LY-404,039 (pomaglumetad)
914:LY-404,039 (pomaglumetad)
303:10.1016/j.bbr.2010.04.006
222:
202:
40:
26:
1569:article relating to the
946:JNJ-40411813 (ADX-71149)
1629:4-Bromophenyl compounds
1624:MGlu8 receptor agonists
398:10.1152/jn.00212.2013
23:
482:10.1111/bcpt.13041
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392:(11): 2196–2209.
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1057:Ibotenic acid
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904:Ibotenic acid
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644:Cyclothiazide
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25:
1579:expanding it
1564:
1531:
1530:
1488:Antagonists:
1487:
1480:
1477:
1457:
1428:
1387:Antagonists:
1386:
1358:
1305:Antagonists:
1304:
1286:
1233:Antagonists:
1232:
1217:
1182:
1135:
1094:Antagonists:
1093:
1087:Talaglumetad
1033:
999:
953:Antagonists:
952:
942:
939:Talaglumetad
875:
812:Dipraglurant
807:Basimglurant
798:
752:Antagonists:
751:
741:
689:
631:Antagonists:
630:
575:
472:
468:
458:
425:
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389:
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249:
248:
75:1290628-31-7
53:
1214:VU-0155,041
1139:Decoglurant
1003:Decoglurant
837:Raseglurant
785:Remeglurant
770:Mavoglurant
634:BAY 36-7620
428:: 124–137.
250:AZ-12216052
176: g·mol
36:Identifiers
1634:Thioethers
1618:Categories
1481:AZ12216052
1221:Foliglurax
1209:VU-001,171
1122:LY-341,495
1117:LY-307,452
1072:LY-487,379
1062:LY-379,268
981:LY-341,495
976:LY-307,452
924:LY-566,332
919:LY-487,379
909:LY-379,268
765:LY-344,545
745:LSN2463359
654:LY-456,236
649:LY-367,385
543:modulators
272:References
181:3D model (
169:Molar mass
111:ChemSpider
66:CAS Number
45:IUPAC name
21:AZ12216052
1532:See also:
1466:Glutamate
1458:Agonists:
1380:LSP2-9166
1367:Glutamate
1359:Agonists:
1290:Glutamate
1287:Agonists:
1199:LSP2-9166
1186:Glutamate
1183:Agonists:
1158:Group III
1144:RO4491533
1052:Glutamate
1047:Eglumegad
1034:Agonists:
1008:RO4491533
899:Glutamate
894:Eglumegad
876:Agonists:
723:Glutamate
698:ADX-47273
690:Agonists:
614:Ro67-7476
609:Ro67-4853
604:Ro01-6128
589:Glutamate
576:Agonists:
346:: 88–94.
1516:UBP-1112
1432:ADX71743
1420:UBP-1112
1333:UBP-1112
1261:UBP-1112
1132:MGS-0039
1077:MGS-0028
991:MGS-0039
929:MGS-0028
851:Group II
795:SIB-1893
790:SIB-1757
780:NPS-2390
664:NPS-2390
624:Theanine
499:21666589
491:29753314
442:25661514
406:24304862
370:23164615
321:20385173
120:29342334
100:73755190
822:GRN-529
817:Fenobam
802:AZD9272
738:VU-1545
639:CPCCOEt
551:Group I
450:8865211
361:3562428
312:2892883
262:anxiety
256:of the
136:Formula
86:PubChem
1639:Amides
1425:XAP044
1362:AMN082
1042:DCG-IV
1037:CBiPES
996:PCCG-4
889:DCG-IV
884:CBiPES
497:
489:
448:
440:
404:
368:
358:
319:
309:
207:SMILES
174:392.36
1573:is a
1565:This
1443:mGluR
1400:MMPIP
1344:mGluR
1272:mGluR
1204:PHCCC
1168:mGluR
1112:HYDIA
1102:CECXG
1097:APICA
1019:mGluR
971:HYDIA
961:CECXG
956:APICA
861:mGluR
760:DMeOB
703:CDPPB
675:mGluR
619:VU-71
561:mGluR
495:S2CID
446:S2CID
227:InChI
183:JSmol
1575:stub
1567:drug
1511:MTPG
1506:MSOP
1501:MPPG
1496:MAP4
1491:CPPG
1474:-AP4
1461:DCPG
1415:MTPG
1410:MSOP
1405:MPPG
1395:MAP4
1390:CPPG
1375:-AP4
1328:MTPG
1323:MSOP
1318:MPPG
1313:MAP4
1308:CPPG
1298:-AP4
1256:MTPG
1251:MSOP
1246:MPPG
1241:MAP4
1236:CPPG
1226:MPEP
1194:-AP4
1127:MCPG
1107:EGLU
986:MCPG
966:EGLU
879:BINA
832:MTEP
827:MPEP
775:MCPG
755:CTEP
718:DHPG
708:CHPG
693:ACPD
659:MCPG
584:DHPG
579:ACPD
487:PMID
438:PMID
402:PMID
366:PMID
317:PMID
264:and
713:DFB
477:doi
473:123
430:doi
394:doi
390:111
356:PMC
348:doi
307:PMC
299:doi
295:212
90:CID
52:2--
1620::
1541:•
1537:•
1476:;
1427:;
1216:;
1134:;
998:;
941:;
797:;
740:;
493:.
485:.
471:.
467:.
444:.
436:.
426:88
424:.
400:.
388:.
364:.
354:.
344:67
342:.
338:.
315:.
305:.
293:.
289:.
268:.
153:Br
150:22
144:19
1606:e
1599:t
1592:v
1581:.
1472:L
1445:8
1373:L
1346:7
1296:L
1274:6
1192:L
1170:4
1021:3
863:2
677:5
563:1
532:e
525:t
518:v
501:.
479::
452:.
432::
408:.
396::
372:.
350::
323:.
301::
185:)
162:S
159:O
156:N
147:H
141:C
54:N
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