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Abelson murine leukemia virus

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33: 226:. However, this is only possible when the host cell is co-infected with a helper virus which provides functions it needs to be able to replicate which it does not code for in its own genome such as a reverse transcriptase and some major structural proteins. As such, A-MuLV can be described as a 254:
studies have shown that lymphocyte infection produces tumor cell populations comprising three types of cells: stable productive cells, non-productive cells and cells which produced defective virus particles which are not infective.
959: 1503: 250:(Ig) on their surface although most tumor cells do not have characteristic receptors on their surface indicating that they are undifferentiated cells. 446: 1015: 1434: 913: 658: 710: 1494: 580: 565: 1541: 1355: 32: 1439: 1230: 1009: 991: 985: 235: 1195: 881: 876: 822: 1220: 887: 852: 1531: 872: 439: 1508: 1250: 1190: 847: 575: 1536: 1225: 1003: 418: 182: 273: 238:(M-MuLV). It causes leukemia directly by interfering with the normal growth and differentiation processes of 511: 1456: 1200: 1185: 506: 522: 414: 1411: 1100: 948: 933: 893: 459: 432: 424: 208: 204: 143: 591: 539: 1117: 316: 27: 1080: 1063: 1046: 753: 1383: 1312: 1295: 684: 1261: 1126: 1089: 827: 770: 736: 1131: 1035: 1020: 904: 802: 570: 556: 393: 344: 285: 953: 383: 375: 334: 324: 189: 997: 924: 863: 813: 497: 464: 129: 93: 81: 69: 320: 1165: 1154: 838: 627: 486: 192: 388: 363: 339: 304: 1525: 725: 638: 475: 215: 1329: 1211: 943: 616: 227: 105: 379: 1488: 1366: 1241: 673: 649: 239: 1479: 1424: 1346: 1176: 970: 791: 364:"Virus production by Abelson murine leukemia virus-transformed lymphoid cells" 247: 178: 117: 1278: 701: 305:"In vitro transformation of lymphoid cells by Abelson murine leukemia virus" 207:. The Abelson murine leukemia virus is named for the American pediatrician 57: 329: 289: 1473: 348: 219: 397: 211:, who together with Louise S Rabstein, first described and isolated it. 243: 246:
which was shown by the fact that some tumor cells can be seen to have
1419: 230:. A highly efficient helper virus commonly used when growing A-MuLV 223: 1450: 455: 186: 44: 274:"Lymphosarcoma: virus-induced thymic-independent disease in mice" 1429: 1454: 428: 979: 200: 196: 195:. As a retrovirus, it has a single-stranded, positive sense 218:
known as Abelson disease in mice, which is a type of
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Natl. Acad. Sci. U.S.A 1221:Carnation etched ring virus 888:Simian-T-lymphotropic virus 853:Jaagsiekte sheep retrovirus 203:intermediate mediated by a 1558: 873:Human T-lymphotropic virus 222:that does not involve the 181:(Class VI) used to induce 1251:Cassava vein mosaic virus 1191:Cacao swollen shoot virus 848:Mouse mammary tumor virus 576:Woodchuck hepatitis virus 26: 21: 1226:Cauliflower mosaic virus 419:Medical Subject Headings 183:malignant transformation 512:Heron hepatitis B virus 1201:Rubus yellow net virus 1186:Banana streak MY virus 507:Duck hepatitis B virus 330:10.1073/pnas.72.5.1932 1542:Animal viral diseases 949:Feline leukemia virus 934:Murine leukemia virus 894:Bovine leukemia virus 205:reverse transcriptase 144:Murine leukemia virus 460:Reverse transcribing 28:Virus classification 523:Herpetohepadnavirus 321:1975PNAS...72.1932R 1127:Simian foamy virus 1101:Prosimiispumavirus 1090:Feline foamy virus 828:Rous sarcoma virus 209:Herbert T. Abelson 1532:Gammaretroviruses 1519: 1518: 1457:Taxon identifiers 1448: 1447: 1406: 1405: 1402: 1401: 1398: 1397: 1148: 1147: 1144: 1143: 1140: 1139: 1132:Human foamy virus 1036:Spumaretrovirinae 1029: 1028: 1021:Visna-maedi virus 905:Epsilonretrovirus 803:Orthoretrovirinae 785: 784: 719: 718: 667: 666: 610: 609: 606: 605: 571:Hepatitis B virus 557:Orthohepadnavirus 242:. It can infect 163: 162: 1549: 1512: 1511: 1499: 1498: 1497: 1484: 1483: 1482: 1452: 1172: 1161: 1155:dsDNA-RT viruses 1042: 954:Koala retrovirus 809: 798: 732: 680: 645: 634: 628:ssRNA-RT viruses 623: 592:Parahepadnavirus 540:Metahepadnavirus 493: 482: 449: 442: 435: 426: 402: 401: 391: 359: 353: 352: 342: 332: 300: 294: 293: 269: 36: 35: 19: 1557: 1556: 1552: 1551: 1550: 1548: 1547: 1546: 1537:Rodent diseases 1522: 1521: 1520: 1515: 1507: 1502: 1493: 1492: 1487: 1478: 1477: 1472: 1459: 1449: 1444: 1394: 1377: 1360: 1340: 1323: 1306: 1289: 1272: 1255: 1235: 1205: 1136: 1118:Simiispumavirus 1111: 1094: 1074: 1057: 1025: 998:Puma lentivirus 964: 925:Gammaretrovirus 918: 898: 864:Deltaretrovirus 857: 832: 814:Alpharetrovirus 781: 764: 747: 715: 695: 663: 602: 585: 550: 533: 516: 498:Avihepadnavirus 469: 465:Revtraviricetes 453: 411: 406: 405: 361: 360: 356: 302: 301: 297: 271: 270: 266: 261: 248:immunoglobulins 159: 147: 131:Gammaretrovirus 95:Revtraviricetes 30: 17: 12: 11: 5: 1555: 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1007: 1001: 995: 989: 983: 976: 974: 966: 965: 963: 962: 957: 951: 946: 941: 936: 930: 928: 920: 919: 917: 916: 910: 908: 900: 899: 897: 896: 891: 885: 879: 869: 867: 859: 858: 856: 855: 850: 844: 842: 839:Betaretrovirus 834: 833: 831: 830: 825: 819: 817: 806: 795: 787: 786: 783: 782: 780: 779: 776: 774: 766: 765: 763: 762: 759: 757: 749: 748: 746: 745: 742: 740: 729: 721: 720: 717: 716: 714: 713: 707: 705: 697: 696: 694: 693: 690: 688: 677: 669: 668: 665: 664: 662: 661: 655: 653: 642: 631: 620: 612: 611: 608: 607: 604: 603: 601: 600: 597: 595: 587: 586: 584: 583: 578: 573: 568: 562: 560: 552: 551: 549: 548: 545: 543: 535: 534: 532: 531: 528: 526: 518: 517: 515: 514: 509: 503: 501: 490: 487:Hepadnaviridae 479: 471: 470: 454: 452: 451: 444: 437: 429: 423: 422: 410: 409:External links 407: 404: 403: 354: 295: 284:(8): 2213–22. 263: 262: 260: 257: 161: 160: 155: 153: 149: 148: 141: 139: 135: 134: 127: 123: 122: 115: 111: 110: 103: 99: 98: 91: 87: 86: 83:Artverviricota 79: 75: 74: 67: 63: 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489: 488: 483: 480: 478: 477: 476:Blubervirales 472: 467: 466: 461: 457: 450: 445: 443: 438: 436: 431: 430: 427: 420: 416: 413: 412: 408: 399: 395: 390: 385: 381: 377: 374:(2): 557–67. 373: 369: 365: 358: 355: 350: 346: 341: 336: 331: 326: 322: 318: 315:(5): 1932–6. 314: 310: 306: 299: 296: 291: 287: 283: 279: 275: 268: 265: 258: 256: 253: 249: 245: 241: 237: 233: 229: 225: 221: 217: 216:lymphosarcoma 212: 210: 206: 202: 198: 194: 191: 188: 184: 180: 176: 172: 168: 158: 154: 151: 150: 146: 145: 140: 137: 136: 133: 132: 128: 125: 124: 121: 120: 116: 113: 112: 109: 108: 104: 101: 100: 97: 96: 92: 89: 88: 85: 84: 80: 77: 76: 73: 72: 68: 65: 64: 61: 60: 56: 53: 50: 49: 46: 43: 40: 39: 34: 29: 25: 20: 1464: 1384:Vaccinivirus 1382: 1365: 1345: 1330:Solendovirus 1328: 1313:Ruflodivirus 1311: 1296:Rosadnavirus 1294: 1277: 1260: 1240: 1212:Caulimovirus 1210: 1175: 1164: 1116: 1099: 1079: 1062: 1045: 1034: 969: 944:Friend virus 938: 923: 903: 862: 837: 812: 801: 792:Retroviridae 790: 769: 752: 735: 724: 700: 685:Errantivirus 683: 672: 648: 637: 617:Ortervirales 615: 590: 555: 538: 521: 496: 485: 474: 463: 371: 367: 357: 312: 308: 298: 281: 277: 267: 251: 231: 228:dependovirus 213: 174: 170: 166: 164: 156: 142: 130: 119:Retroviridae 118: 107:Ortervirales 106: 94: 82: 71:Pararnavirae 70: 58: 51: 41:(unranked): 1489:Wikispecies 1367:Tungrovirus 1262:Dioscovirus 1242:Cavemovirus 890:(types 1-4) 754:Pseudovirus 674:Metaviridae 650:Semotivirus 240:lymphocytes 1526:Categories 1412:Endogenous 1347:Soymovirus 1177:Badnavirus 971:Lentivirus 278:Cancer Res 259:References 179:retrovirus 16:Retrovirus 1279:Petuvirus 771:Sirevirus 737:Hemivirus 702:Metavirus 462:viruses ( 138:Species: 66:Kingdom: 59:Riboviria 1480:Q4666726 1474:Wikidata 368:J. Virol 252:In vitro 232:in vitro 220:leukemia 190:lymphoid 114:Family: 78:Phylum: 884:, 3, 4) 317:Bibcode 290:4318922 244:B-cells 177:) is a 152:Virus: 126:Genus: 102:Order: 90:Class: 1425:ERVWE1 1420:ERV-Fc 1006:(EIAV) 956:(KoRV) 882:HTLV-2 877:HTLV-1 421:(MeSH) 396:  389:353478 386:  349:168584 347:  340:432662 337:  288:  224:thymus 187:murine 175:A-MuLV 171:Ab-MLV 1509:11788 1012:(BIV) 1000:(PLV) 994:(FIV) 988:(SIV) 456:Virus 398:90175 193:cells 52:Realm 45:Virus 1504:NCBI 1430:HCP5 394:PMID 345:PMID 286:PMID 165:The 980:HIV 384:PMC 376:doi 335:PMC 325:doi 234:is 201:DNA 197:RNA 185:of 173:or 1528:: 1506:: 1491:: 1476:: 458:: 392:. 382:. 372:31 370:. 366:. 343:. 333:. 323:. 313:72 311:. 307:. 282:30 280:. 276:. 54:: 1157:) 1153:( 875:( 630:) 626:( 468:) 448:e 441:t 434:v 400:. 378:: 351:. 327:: 319:: 292:. 169:(

Index

Virus classification
Edit this classification
Virus
Riboviria
Pararnavirae
Artverviricota
Revtraviricetes
Ortervirales
Retroviridae
Gammaretrovirus
Murine leukemia virus
retrovirus
malignant transformation
murine
lymphoid
cells
RNA
DNA
reverse transcriptase
Herbert T. Abelson
lymphosarcoma
leukemia
thymus
dependovirus
Moloney murine leukemia virus
lymphocytes
B-cells
immunoglobulins
"Lymphosarcoma: virus-induced thymic-independent disease in mice"
PMID

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